CA2938103C - Crystalline forms of dolutegravir sodium - Google Patents

Crystalline forms of dolutegravir sodium Download PDF

Info

Publication number
CA2938103C
CA2938103C CA2938103A CA2938103A CA2938103C CA 2938103 C CA2938103 C CA 2938103C CA 2938103 A CA2938103 A CA 2938103A CA 2938103 A CA2938103 A CA 2938103A CA 2938103 C CA2938103 C CA 2938103C
Authority
CA
Canada
Prior art keywords
dolutegravir sodium
sodium form
crystalline
dolutegravir
crystalline dolutegravir
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2938103A
Other languages
English (en)
French (fr)
Other versions
CA2938103A1 (en
Inventor
Ramakoteswara Rao Jetti
Satish BEERAVELLY
Madhu Murthy Nadella
Haribabu NANDIPATI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mylan Laboratories Ltd
Original Assignee
Mylan Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Ltd filed Critical Mylan Laboratories Ltd
Publication of CA2938103A1 publication Critical patent/CA2938103A1/en
Application granted granted Critical
Publication of CA2938103C publication Critical patent/CA2938103C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2938103A 2014-02-07 2015-02-04 Crystalline forms of dolutegravir sodium Active CA2938103C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN455/MUM/2014 2014-02-07
IN455MU2014 IN2014MU00455A (2) 2014-02-07 2015-02-04
PCT/IB2015/050841 WO2015118460A1 (en) 2014-02-07 2015-02-04 Crystalline forms of dolutegravir sodium

Publications (2)

Publication Number Publication Date
CA2938103A1 CA2938103A1 (en) 2015-08-13
CA2938103C true CA2938103C (en) 2021-08-10

Family

ID=53777379

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2938103A Active CA2938103C (en) 2014-02-07 2015-02-04 Crystalline forms of dolutegravir sodium

Country Status (7)

Country Link
US (1) US10087193B2 (2)
EP (1) EP3102582A1 (2)
AU (1) AU2015215630B2 (2)
BR (1) BR112016018056A2 (2)
CA (1) CA2938103C (2)
IN (1) IN2014MU00455A (2)
WO (1) WO2015118460A1 (2)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107074875B (zh) * 2014-07-29 2019-03-29 斯洛文尼亚莱柯制药股份有限公司 度鲁特韦钠的新水合物
WO2017029642A2 (en) 2015-08-19 2017-02-23 Laurus Labs Private Limited Novel polymorphs of dolutegravir and salts thereof
WO2017046131A1 (en) * 2015-09-15 2017-03-23 Ratiopharm Gmbh Processes for preparing solid state forms of dolutegravir sodium
WO2017208105A1 (en) 2016-05-30 2017-12-07 Lupin Limited Novel crystalline form of dolutegravir sodium
BR112019027915A2 (pt) * 2017-06-30 2020-07-14 Viiv Healthcare Company composição de carboidrato de baixo teor glicêmico disponível, composição nutricional líquida, e, uso de uma composição de carboidrato
US20210040116A1 (en) 2017-09-07 2021-02-11 Cipla Limited New Polymorphs of Dolutegravir Sodium
US12227518B2 (en) * 2019-02-05 2025-02-18 Msn Laboratories Private Limited, R&D Center Crystalline polymorphs of sodium (4R,12AS)-9-{[(2,4-difluorophenyl) methyl]carbamoyl}-4-methyl-6,8-dioxo-3,4,6,8,12,12A-hexahydro-2H-pyrido [1′,2′:4,5]pyrazino[2,1-b][1,3]oxazin-7-olate and process for preparation thereof
CN114213432B (zh) * 2021-12-31 2023-02-17 瑞孚信江苏药业股份有限公司 度鲁特韦的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3210603A1 (en) 2008-12-11 2017-08-30 Shionogi & Co., Ltd Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates
PL2742051T3 (pl) 2011-09-14 2017-06-30 Mapi Pharma Limited Amorficzna postać soli sodowej dolutegrawiru
WO2015009927A1 (en) 2013-07-17 2015-01-22 Ratiopharm Gmbh Dolutegravir salts
WO2015019310A1 (en) * 2013-08-07 2015-02-12 Mylan Laboratories Ltd Process for the preparation of dolute-gravir and intermediates thereof

Also Published As

Publication number Publication date
US10087193B2 (en) 2018-10-02
US20160347766A1 (en) 2016-12-01
CA2938103A1 (en) 2015-08-13
AU2015215630B2 (en) 2018-08-16
IN2014MU00455A (2) 2015-09-25
EP3102582A1 (en) 2016-12-14
BR112016018056A2 (pt) 2017-08-08
AU2015215630A1 (en) 2016-09-22
WO2015118460A1 (en) 2015-08-13

Similar Documents

Publication Publication Date Title
CA2938103C (en) Crystalline forms of dolutegravir sodium
WO2016038532A1 (en) Amorphous treprostinil diethanolamine
WO2015092752A1 (en) Novel crystalline form of dolutegravir sodium
WO2016125123A1 (en) Amorphous trisodium sacubitril valsartan and a process for the preparation thereof
AU2017376517A1 (en) Novel crystalline forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl] amino} acetic acid and processes for preparation thereof
JP2025106244A (ja) リジニラゾールの調製方法およびその結晶形態
WO2016135755A1 (en) Amorphous apremilast, premixes thereof, and novel crystalline forms of apremilast
WO2016012539A1 (en) A process for the preparation of cgmp-phosphodiesterase inhibitor and oral pharmaceutical formulation comprising tadalafil co-precipitates
WO2017163190A1 (en) Amorphous ixazomib citrate and solid dispersion thereof
ES2528188T3 (es) Método para preparar zofenopril cálcico
CN106458886A (zh) 药物活性化合物的固体形式
US20110189280A1 (en) Dosage form comprising 1-isopropyl-4-hexahydro-1h-1,4-diazepine or a salt thereof
EP2714683A2 (en) Amorphous ritonavir co-precipitated
WO2017077551A2 (en) An amorphous nintedanib esylate and solid dispersion thereof
WO2019207602A1 (en) Polymorphic forms of bictegravir and its sodium salt
AU2023216691A1 (en) Crystalline forms of an mcl-1 inhibitor
US20180030038A1 (en) Polymorphic Forms of Afatinib Dimaleate
EP2841419A1 (en) Crystalline forms of saxagliptin
TW201734023A (zh) 溫諾平(vinorelbine)單酒石酸鹽及其藥學用途
WO2016147206A1 (en) Process for the preparation of amorphous idelalisib and its premix
KR102100357B1 (ko) 5-클로로-ｎ-({(5ｓ)-2-옥소-3-[4-(5,6-디하이드로-4h-[1,2,4]트리아진-1-일)페닐]-1,3-옥사졸리딘-5-일}메틸)티오펜-2-카르복사미드 메탄설폰산염의 신규 결정형 및 이를 포함하는 약학 조성물
WO2014013505A2 (en) Amorphous vildagliptin
US20140066468A1 (en) Amorphous form of lopinavir and ritonavir mixture
WO2017093789A1 (en) Polymorphic forms of afatinib dimaleate
HK40016752A (en) Crystalline form of gcc-4401c and pharmaceutical composition comprising the crystalline form

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20200204

R11 Change to the name of applicant or owner or transfer of ownership requested

Free format text: ST27 STATUS EVENT CODE: A-4-4-R10-R11-R127 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER RECORDAL REQUEST OR RESPONSE

Effective date: 20250423

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20250515

R14 Transfer of ownership recorded

Free format text: ST27 STATUS EVENT CODE: A-4-4-R10-R14-R129 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TRANSFER REQUIREMENTS DETERMINED COMPLIANT

Effective date: 20250910

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: A-4-4-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20251001