CA2934078C - Extruded extended release abuse deterrent pill - Google Patents

Extruded extended release abuse deterrent pill Download PDF

Info

Publication number
CA2934078C
CA2934078C CA2934078A CA2934078A CA2934078C CA 2934078 C CA2934078 C CA 2934078C CA 2934078 A CA2934078 A CA 2934078A CA 2934078 A CA2934078 A CA 2934078A CA 2934078 C CA2934078 C CA 2934078C
Authority
CA
Canada
Prior art keywords
extended release
formulation
oral
abuse deterrent
abuse
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2934078A
Other languages
English (en)
French (fr)
Other versions
CA2934078A1 (en
Inventor
Edwin R. Thompson
Eric R. Thompson
Nicholas R. Myslinski
Steven F. Kemeny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PHARMACEUTICAL MANUFACTURING RESEARCH SERVICES Inc
Original Assignee
PHARMACEUTICAL MANUFACTURING RESEARCH SERVICES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/457,714 external-priority patent/US10195153B2/en
Application filed by PHARMACEUTICAL MANUFACTURING RESEARCH SERVICES Inc filed Critical PHARMACEUTICAL MANUFACTURING RESEARCH SERVICES Inc
Publication of CA2934078A1 publication Critical patent/CA2934078A1/en
Application granted granted Critical
Publication of CA2934078C publication Critical patent/CA2934078C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2934078A 2013-12-17 2014-12-17 Extruded extended release abuse deterrent pill Expired - Fee Related CA2934078C (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361917074P 2013-12-17 2013-12-17
US201361917120P 2013-12-17 2013-12-17
US61/917,120 2013-12-17
US61/917,074 2013-12-17
US201461980254P 2014-04-16 2014-04-16
US201461980259P 2014-04-16 2014-04-16
US61/980,254 2014-04-16
US61/980,259 2014-04-16
US14/457,714 US10195153B2 (en) 2013-08-12 2014-08-12 Extruded immediate release abuse deterrent pill
US14/457,714 2014-08-12
PCT/US2014/070942 WO2015095387A1 (en) 2013-12-17 2014-12-17 Extruded extended release abuse deterrent pill

Publications (2)

Publication Number Publication Date
CA2934078A1 CA2934078A1 (en) 2015-06-25
CA2934078C true CA2934078C (en) 2019-08-06

Family

ID=53403652

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2934078A Expired - Fee Related CA2934078C (en) 2013-12-17 2014-12-17 Extruded extended release abuse deterrent pill

Country Status (5)

Country Link
EP (1) EP3082775A4 (ja)
JP (2) JP6403780B2 (ja)
AU (3) AU2014364800A1 (ja)
CA (1) CA2934078C (ja)
WO (1) WO2015095387A1 (ja)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1014941T3 (da) * 1996-06-26 2009-07-27 Univ Texas Ekstruderbar farmaceutisk hot-melt-formulering
CA2572491A1 (en) * 2004-07-01 2006-01-12 Gruenenthal Gmbh Oral dosage form safeguarded against abuse
US20080152595A1 (en) * 2004-11-24 2008-06-26 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
DE102007011485A1 (de) * 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
GB0909680D0 (en) * 2009-06-05 2009-07-22 Euro Celtique Sa Dosage form
BR112014002022A2 (pt) * 2011-07-29 2017-02-21 Gruenenthal Gmbh comprimido resistente à violação proporcionando liberação de fármaco imediata
JP6103785B2 (ja) * 2012-04-18 2017-03-29 マリンクロッド エルエルシー 乱用抑止特性を有する即放性医薬組成物
NZ704011A (en) * 2012-07-06 2016-04-29 Egalet Ltd Abuse deterrent pharmaceutical compositions for controlled release
WO2015023675A2 (en) * 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill

Also Published As

Publication number Publication date
JP2019001816A (ja) 2019-01-10
WO2015095387A1 (en) 2015-06-25
AU2018253567A1 (en) 2018-11-08
CA2934078A1 (en) 2015-06-25
EP3082775A1 (en) 2016-10-26
AU2019216710A1 (en) 2019-09-12
JP6678212B2 (ja) 2020-04-08
EP3082775A4 (en) 2017-05-17
AU2018253567B2 (en) 2019-05-23
JP6403780B2 (ja) 2018-10-10
JP2017503780A (ja) 2017-02-02
AU2014364800A1 (en) 2016-07-07

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20170227

MKLA Lapsed

Effective date: 20201217