CA2928510A1 - Materials and methods for diagnosis and prognosis of liver cancer - Google Patents
Materials and methods for diagnosis and prognosis of liver cancer Download PDFInfo
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- CA2928510A1 CA2928510A1 CA2928510A CA2928510A CA2928510A1 CA 2928510 A1 CA2928510 A1 CA 2928510A1 CA 2928510 A CA2928510 A CA 2928510A CA 2928510 A CA2928510 A CA 2928510A CA 2928510 A1 CA2928510 A1 CA 2928510A1
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Classifications
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis
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- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
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| GB1320061.3 | 2013-11-13 | ||
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| PCT/GB2014/053368 WO2015071669A2 (en) | 2013-11-13 | 2014-11-13 | Materials and methods for diagnosis and prognosis of liver cancer |
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| CA2928510A1 true CA2928510A1 (en) | 2015-05-21 |
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| CA2928510A Abandoned CA2928510A1 (en) | 2013-11-13 | 2014-11-13 | Materials and methods for diagnosis and prognosis of liver cancer |
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| EP (1) | EP3069142A2 (enExample) |
| JP (1) | JP2016538545A (enExample) |
| CA (1) | CA2928510A1 (enExample) |
| GB (1) | GB201320061D0 (enExample) |
| WO (1) | WO2015071669A2 (enExample) |
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| CN105288659B (zh) * | 2015-06-01 | 2019-07-26 | 北京泱深生物信息技术有限公司 | Tenm1基因及其表达产物在诊治乳头状腺癌的应用 |
| KR101750411B1 (ko) * | 2015-07-10 | 2017-06-27 | 한국생명공학연구원 | 엑소좀 단백질 eif3a 특이반응 오토항체검출용 항원 조성물 및 이를 이용한 간암진단법 |
| FR3048780B1 (fr) * | 2016-03-11 | 2020-11-06 | Commissariat Energie Atomique | Procede de diagnostic in vitro d'atteintes hepatiques |
| EP3403100B1 (fr) * | 2016-01-15 | 2020-03-11 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Procédé de diagnostic in vitro d'atteintes hépatiques |
| GB201616912D0 (en) * | 2016-10-05 | 2016-11-16 | University Of East Anglia | Classification of cancer |
| GB201619954D0 (en) * | 2016-11-25 | 2017-01-11 | Oncimmune Ltd | Antibody assay |
| KR102712656B1 (ko) | 2017-01-23 | 2024-10-04 | 리제너론 파마슈티칼스 인코포레이티드 | Hsd17b13 변종 및 이것의 용도 |
| CN115266962B (zh) * | 2017-03-31 | 2024-05-31 | 北京谷海天目生物医学科技有限公司 | 蛋白标志物在制备弥漫型胃癌分子分型的产品中的应用及弥漫型胃癌分子分型的分类器 |
| US11479802B2 (en) | 2017-04-11 | 2022-10-25 | Regeneron Pharmaceuticals, Inc. | Assays for screening activity of modulators of members of the hydroxy steroid (17-beta) dehydrogenase (HSD17B) family |
| WO2018189215A1 (en) * | 2017-04-12 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for predicting the survival time of a patient suffering from hepatocellular carcinoma |
| AU2018348195B2 (en) | 2017-10-11 | 2025-05-15 | Regeneron Pharmaceuticals, Inc. | Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation |
| CN109596829A (zh) * | 2017-12-07 | 2019-04-09 | 南京医科大学 | 一种肝癌标志蛋白及其检测方法 |
| WO2019115679A1 (en) * | 2017-12-13 | 2019-06-20 | Fundació Institut D'investigació En Ciències De La Salut Germans Trias I Pujol | A signature to assess prognosis and therapeutic regimen in liver cancer |
| BR112020018758A2 (pt) | 2018-03-21 | 2021-01-26 | Regeneron Pharmaceuticals, Inc. | agente de ácido ribonucleico de fita dupla, célula, vetor, composição farmacêutica, e, métodos para inibição da expressão de 17¿-hidroxiesteroide desidrogenases tipo 13, para tratamento de um indivíduo, para prevenção de um sintoma em um indivíduo, para redução do risco de desenvolver doença hepática crônica, para inibição da progressão de esteatose, para inibição do acúmulo de gotículas de lipídios |
| US20220244263A1 (en) * | 2019-05-28 | 2022-08-04 | The Regents Of The University Of California | Methods for treating small cell neuroendocrine and related cancers |
| CA3166923A1 (en) * | 2020-02-10 | 2021-08-19 | Somalogic Operating Co., Inc. | Nonalcoholic steatohepatitis (nash) biomarkers and uses thereof |
| EP4115181A1 (en) * | 2020-03-02 | 2023-01-11 | Université de Strasbourg | Method for diagnosis and/or prognosis of liver disease progression and risk of hepatocellular carcinoma and discovery of therapeutic compounds and targets to treat liver disease and cancer |
| JP7471898B2 (ja) * | 2020-04-17 | 2024-04-22 | 合同会社Ｈ．Ｕ．グループ中央研究所 | 胆管がんのバイオマーカー |
| CN111748624B (zh) * | 2020-06-08 | 2022-11-04 | 郑州大学第一附属医院 | 用于预测肝癌是否复发的生物标志物 |
| CN111748623B (zh) * | 2020-06-08 | 2022-11-04 | 郑州大学第一附属医院 | 肝癌患者是否复发的预测标志物及试剂盒 |
| CN112961916B (zh) * | 2020-11-10 | 2024-03-12 | 上海市肿瘤研究所 | Akr1c3作为肝癌预后的生物学标志物及其应用 |
| CN112908470B (zh) * | 2021-02-08 | 2023-10-03 | 深圳市人民医院 | 一种基于rna结合蛋白基因的肝细胞癌预后评分系统及其应用 |
| CN113462777A (zh) * | 2021-06-28 | 2021-10-01 | 武汉大学 | P4hb在制备肝细胞癌早期诊断试剂盒及制备或筛选抗肝癌药物中的应用 |
| CN114814001B (zh) * | 2022-03-31 | 2023-02-21 | 武汉大学 | 用于制备肝癌检测试剂的新型代谢标志物及其应用 |
| CN115754290A (zh) * | 2022-09-26 | 2023-03-07 | 浙江大学 | 一种用于检测早期肝癌的试剂盒 |
| CN115807089B (zh) * | 2022-11-14 | 2024-09-13 | 石河子大学 | 肝细胞肝癌预后生物标志物及应用 |
| CN116338189B (zh) * | 2023-01-16 | 2025-08-22 | 浙江大学医学院附属第一医院 | 具有蛋白激酶功能的肿瘤标志物ckb在制备肿瘤诊断产品中的应用 |
| CN116386715A (zh) * | 2023-03-09 | 2023-07-04 | 福建医科大学孟超肝胆医院 | 用于原发性肝细胞癌蛋白质组分子分型诊断的特征蛋白及其应用 |
| CN117607438A (zh) * | 2023-11-23 | 2024-02-27 | 浙江大学 | 一种肝细胞癌鉴别诊断和分化程度检测方法 |
| CN119314683B (zh) * | 2024-12-17 | 2025-02-25 | 吉林大学第一医院 | 一种用于肝移植术后预测系统 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| KR970002255B1 (ko) | 1990-06-11 | 1997-02-26 | 넥스스타 파아마슈티컬드, 인크. | 핵산 리간드 |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| DE60239962D1 (de) | 2001-08-14 | 2011-06-16 | Harvard College | Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie |
| WO2006076100A2 (en) * | 2004-12-09 | 2006-07-20 | Eisai Co. Ltd. | Tubulin isotype screening in cancer therapy using halichondrin b analogs |
| US20060148014A1 (en) * | 2004-12-09 | 2006-07-06 | Sergei Agoulnik | Tubulin isotype screening in cancer therapy using hemiasterlin analogs |
| US20080161203A1 (en) * | 2006-12-27 | 2008-07-03 | Su Chun-Lin | Markers identified for liver fibrosis and cirrhosis and the microarray panel thereof |
| GB0704764D0 (en) | 2007-03-12 | 2007-04-18 | Electrophoretics Ltd | Isobarically labelled reagents and methods of their use |
| JPWO2009113495A1 (ja) * | 2008-03-12 | 2011-07-21 | 財団法人ヒューマンサイエンス振興財団 | 肝癌特異的発現遺伝子による肝癌の検査方法並びに肝癌の治療及び予防剤 |
| CA2785389A1 (en) * | 2009-12-25 | 2011-06-30 | Taiho Pharmaceutical Co., Ltd. | Antitumor agent or postoperative adjuvant chemotherapeutic agent for hepatocellular carcinoma treatment |
| HK1199099A1 (en) * | 2011-08-31 | 2015-06-19 | Oncocyte Corporation | Methods and compositions for the treatment and diagnosis of cancer |
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- 2013-11-13 GB GBGB1320061.3A patent/GB201320061D0/en not_active Ceased
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2014
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- 2014-11-13 WO PCT/GB2014/053368 patent/WO2015071669A2/en not_active Ceased
- 2014-11-13 JP JP2016530873A patent/JP2016538545A/ja active Pending
- 2014-11-13 CA CA2928510A patent/CA2928510A1/en not_active Abandoned
- 2014-11-13 EP EP14814986.7A patent/EP3069142A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| GB201320061D0 (en) | 2013-12-25 |
| US20160320395A1 (en) | 2016-11-03 |
| JP2016538545A (ja) | 2016-12-08 |
| EP3069142A2 (en) | 2016-09-21 |
| WO2015071669A2 (en) | 2015-05-21 |
| WO2015071669A3 (en) | 2015-09-17 |
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