CA2927947A1 - Systemes, dispositifs et procedes pour la culture, la manipulation et l'analyse microfluidiques de tissus et de cellules - Google Patents

Systemes, dispositifs et procedes pour la culture, la manipulation et l'analyse microfluidiques de tissus et de cellules Download PDF

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Publication number
CA2927947A1
CA2927947A1 CA2927947A CA2927947A CA2927947A1 CA 2927947 A1 CA2927947 A1 CA 2927947A1 CA 2927947 A CA2927947 A CA 2927947A CA 2927947 A CA2927947 A CA 2927947A CA 2927947 A1 CA2927947 A1 CA 2927947A1
Authority
CA
Canada
Prior art keywords
cell
microfluidic device
layer
chamber
inlet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2927947A
Other languages
English (en)
Inventor
Ashok C. Chander
Wendell R. SU
Thiagarajan MEYYAPPAN
Jonathan VARSANIK
Senthil Ramu
Michael MANAK
Brad HOGAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellanyx Diagnostics LLC
Original Assignee
Cellanyx Diagnostics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellanyx Diagnostics LLC filed Critical Cellanyx Diagnostics LLC
Publication of CA2927947A1 publication Critical patent/CA2927947A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/22—Transparent or translucent parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2927947A 2013-10-22 2014-10-22 Systemes, dispositifs et procedes pour la culture, la manipulation et l'analyse microfluidiques de tissus et de cellules Abandoned CA2927947A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361894298P 2013-10-22 2013-10-22
US61/894,298 2013-10-22
PCT/US2014/061782 WO2015061458A1 (fr) 2013-10-22 2014-10-22 Systèmes, dispositifs et procédés pour la culture, la manipulation et l'analyse microfluidiques de tissus et de cellules

Publications (1)

Publication Number Publication Date
CA2927947A1 true CA2927947A1 (fr) 2015-04-30

Family

ID=52993507

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2927947A Abandoned CA2927947A1 (fr) 2013-10-22 2014-10-22 Systemes, dispositifs et procedes pour la culture, la manipulation et l'analyse microfluidiques de tissus et de cellules

Country Status (3)

Country Link
EP (1) EP3060648A4 (fr)
CA (1) CA2927947A1 (fr)
WO (1) WO2015061458A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4139049A1 (fr) * 2020-04-22 2023-03-01 Agency for Science, Technology and Research Dispositif d'étude d'interactions d'un premier type de cellule avec un second type de cellule et procédé associé

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2656156C2 (ru) 2011-10-17 2018-05-31 Массачусетс Инститьют Оф Текнолоджи Внутриклеточная доставка
WO2015023982A1 (fr) 2013-08-16 2015-02-19 Massachusetts Institute Of Technology Administration sélective de matériau à des cellules
CN107109362A (zh) 2014-10-31 2017-08-29 麻省理工学院 递送生物分子至免疫细胞
WO2016077761A1 (fr) 2014-11-14 2016-05-19 Massachusetts Institute Of Technology Acheminement de composés et de compositions dans des cellules activé par des perturbations et un champ
JP7278027B2 (ja) 2015-01-12 2023-05-19 マサチューセッツ インスティテュート オブ テクノロジー マイクロ流体送達による遺伝子編集
CA2988996A1 (fr) 2015-07-09 2017-01-12 Massachusetts Institute Of Technology Administration de substances a des cellules anucleees
EP3365269A4 (fr) * 2015-10-19 2019-06-19 The Methodist Hospital Distribution, par déformation membranaire, de crispr-cas9 à des cellules difficiles à transfecter
WO2017197343A2 (fr) * 2016-05-12 2017-11-16 10X Genomics, Inc. Filtres microfluidiques sur puce
EP3556845A1 (fr) * 2018-04-20 2019-10-23 Cellix Limited Procédé et dispositif de transfection de cellules
CN113522383B (zh) * 2021-06-25 2023-02-24 东南大学 细胞工况化装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8304209B2 (en) * 2008-12-11 2012-11-06 Joule Unlimited Technologies, Inc. Solar biofactory, photobioreactors, passive thermal regulation systems and methods for producing products
WO2011014674A2 (fr) * 2009-07-29 2011-02-03 Cornell University Dispositif microfluidique pour l’étude pharmacocinétique – pharmacodynamique de médicaments et ses utilisations
US20110136162A1 (en) * 2009-08-31 2011-06-09 Drexel University Compositions and Methods for Functionalized Patterning of Tissue Engineering Substrates Including Bioprinting Cell-Laden Constructs for Multicompartment Tissue Chambers
SG189308A1 (en) * 2010-10-08 2013-05-31 Ashok C Chander Systems, methods and devices for measuring growth/oncogenic & migration/metastatic potential
US20130143230A1 (en) * 2011-12-02 2013-06-06 The Trustees Of The Stevens Institute Of Technology Microfluidic-based cell-culturing platform and method
ES2870857T3 (es) * 2011-12-03 2021-10-27 Emd Millipore Corp Sistema microfluídico para cultivo celular

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4139049A1 (fr) * 2020-04-22 2023-03-01 Agency for Science, Technology and Research Dispositif d'étude d'interactions d'un premier type de cellule avec un second type de cellule et procédé associé

Also Published As

Publication number Publication date
WO2015061458A1 (fr) 2015-04-30
EP3060648A4 (fr) 2017-05-31
EP3060648A1 (fr) 2016-08-31

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Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20191022