CA2906299C - Lymphocyte biomarkers for determining the clinical response to cell therapy - Google Patents

Lymphocyte biomarkers for determining the clinical response to cell therapy Download PDF

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Publication number
CA2906299C
CA2906299C CA2906299A CA2906299A CA2906299C CA 2906299 C CA2906299 C CA 2906299C CA 2906299 A CA2906299 A CA 2906299A CA 2906299 A CA2906299 A CA 2906299A CA 2906299 C CA2906299 C CA 2906299C
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Prior art keywords
stem cells
cells
mesenchymal stem
pharmaceutical composition
patient
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CA2906299A
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English (en)
French (fr)
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CA2906299A1 (en
Inventor
Olga De La Rosa
Eleuterio Lombardo
Wilfried Dalemans
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Tigenix SA
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Tigenix SA
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/33Fibroblasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/20Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/22Immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/416Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966Animal cells
    • G01N33/56972White blood cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/50Cellular immunotherapy characterised by the use of allogeneic cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70514CD4
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70517CD8
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539MHC-molecules, e.g. HLA-molecules
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
CA2906299A 2013-03-15 2014-03-17 Lymphocyte biomarkers for determining the clinical response to cell therapy Active CA2906299C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3188652A CA3188652A1 (en) 2013-03-15 2014-03-17 Lymphocyte biomarkers for determining the clinical response to cell therapy

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13382091 2013-03-15
EP13382091.0 2013-03-15
PCT/EP2014/055282 WO2014140362A2 (en) 2013-03-15 2014-03-17 Lymphocyte biomarkers for determining the clinical response to cell therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3188652A Division CA3188652A1 (en) 2013-03-15 2014-03-17 Lymphocyte biomarkers for determining the clinical response to cell therapy

Publications (2)

Publication Number Publication Date
CA2906299A1 CA2906299A1 (en) 2014-09-18
CA2906299C true CA2906299C (en) 2023-04-04

Family

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Application Number Title Priority Date Filing Date
CA2906299A Active CA2906299C (en) 2013-03-15 2014-03-17 Lymphocyte biomarkers for determining the clinical response to cell therapy
CA3188652A Pending CA3188652A1 (en) 2013-03-15 2014-03-17 Lymphocyte biomarkers for determining the clinical response to cell therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3188652A Pending CA3188652A1 (en) 2013-03-15 2014-03-17 Lymphocyte biomarkers for determining the clinical response to cell therapy

Country Status (13)

Country Link
US (2) US10660920B2 (enExample)
EP (2) EP2972368B1 (enExample)
JP (2) JP6567430B2 (enExample)
AU (2) AU2014230014B2 (enExample)
CA (2) CA2906299C (enExample)
DK (1) DK2972368T3 (enExample)
ES (1) ES2748825T3 (enExample)
HU (1) HUE046531T2 (enExample)
IL (1) IL241586B (enExample)
PL (1) PL2972368T3 (enExample)
PT (1) PT2972368T (enExample)
SG (1) SG11201507521UA (enExample)
WO (1) WO2014140362A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
JP5925408B2 (ja) 2005-09-23 2016-05-25 タイジェニックス、ソシエダッド、アノニマ、ウニペルソナルTigenix S.A.U. 免疫調節活性を有する細胞集団、単離方法および使用
AU2014230014B2 (en) 2013-03-15 2019-11-14 Tigenix, S.A.U. Lymphocyte biomarkers for determining the clinical response to therapy with mesenschymal stromal cells(MSC)
WO2016170187A2 (en) * 2015-04-24 2016-10-27 Tigenix, S.A.U Biomarkers for determining the clinical response to cell therapy
GB201604304D0 (en) * 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
CA3043594C (en) * 2016-11-11 2025-10-07 Longeveron Llc Methods of using human mesenchymal stem cells to effect cellular and humoral immunity
CN113544261B (zh) * 2019-02-27 2024-10-01 武田药品工业株式会社 用于同种异体疗法的改良的干细胞群
WO2021207192A1 (en) * 2020-04-08 2021-10-14 Figene, Llc Methods and compositions for allergy and asthma treatment using fibroblasts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60043511D1 (de) * 1999-10-20 2010-01-21 Chugai Pharmaceutical Co Ltd Verwendung von g-csf zur hemmung der gvhd
EP2298861B1 (en) * 2004-03-22 2017-09-13 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
EP1871419A4 (en) * 2005-04-22 2009-01-14 Univ Maryland METHODS OF TREATING REJECTION OF GRAFT AGAINST HOST
US8785190B2 (en) * 2011-04-06 2014-07-22 Sanbio, Inc. Methods and compositions for modulating peripheral immune function
AU2014230014B2 (en) 2013-03-15 2019-11-14 Tigenix, S.A.U. Lymphocyte biomarkers for determining the clinical response to therapy with mesenschymal stromal cells(MSC)

Also Published As

Publication number Publication date
AU2014230014A1 (en) 2015-10-29
EP2972368B1 (en) 2019-07-24
ES2748825T3 (es) 2020-03-18
AU2014230014B2 (en) 2019-11-14
IL241586B (en) 2019-02-28
EP3581932A1 (en) 2019-12-18
DK2972368T3 (da) 2019-10-07
WO2014140362A3 (en) 2015-04-16
PL2972368T3 (pl) 2020-03-31
US11478511B2 (en) 2022-10-25
HK1219775A1 (en) 2017-04-13
SG11201507521UA (en) 2015-10-29
JP2019215359A (ja) 2019-12-19
JP6567430B2 (ja) 2019-08-28
CA2906299A1 (en) 2014-09-18
US20160067285A1 (en) 2016-03-10
JP2016516985A (ja) 2016-06-09
AU2020200807B2 (en) 2021-10-28
AU2020200807A1 (en) 2020-02-20
JP6883070B2 (ja) 2021-06-09
PT2972368T (pt) 2019-10-18
WO2014140362A2 (en) 2014-09-18
US20200261511A1 (en) 2020-08-20
EP2972368A2 (en) 2016-01-20
HUE046531T2 (hu) 2020-03-30
US10660920B2 (en) 2020-05-26
CA3188652A1 (en) 2014-09-18

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