CA2901761A1 - Gene signatures for lung cancer prognosis and therapy selection - Google Patents
Gene signatures for lung cancer prognosis and therapy selection Download PDFInfo
- Publication number
- CA2901761A1 CA2901761A1 CA2901761A CA2901761A CA2901761A1 CA 2901761 A1 CA2901761 A1 CA 2901761A1 CA 2901761 A CA2901761 A CA 2901761A CA 2901761 A CA2901761 A CA 2901761A CA 2901761 A1 CA2901761 A1 CA 2901761A1
- Authority
- CA
- Canada
- Prior art keywords
- genes
- ccgs
- asf1b
- panel
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000004393 prognosis Methods 0.000 title claims abstract description 72
- 206010058467 Lung neoplasm malignant Diseases 0.000 title claims abstract description 70
- 201000005202 lung cancer Diseases 0.000 title claims abstract description 70
- 208000020816 lung neoplasm Diseases 0.000 title claims abstract description 70
- 238000002560 therapeutic procedure Methods 0.000 title abstract description 9
- 230000004547 gene signature Effects 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract description 114
- 108090000623 proteins and genes Proteins 0.000 claims description 494
- 238000012360 testing method Methods 0.000 claims description 314
- 230000014509 gene expression Effects 0.000 claims description 263
- 239000000523 sample Substances 0.000 claims description 140
- 206010028980 Neoplasm Diseases 0.000 claims description 134
- 230000004044 response Effects 0.000 claims description 132
- 238000011269 treatment regimen Methods 0.000 claims description 79
- 238000011282 treatment Methods 0.000 claims description 66
- 201000011510 cancer Diseases 0.000 claims description 63
- 238000002512 chemotherapy Methods 0.000 claims description 59
- 238000010837 poor prognosis Methods 0.000 claims description 34
- 230000034994 death Effects 0.000 claims description 32
- 231100000517 death Toxicity 0.000 claims description 32
- 238000004590 computer program Methods 0.000 claims description 26
- 108020004999 messenger RNA Proteins 0.000 claims description 22
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 19
- 108700039887 Essential Genes Proteins 0.000 claims description 19
- 238000012408 PCR amplification Methods 0.000 claims description 15
- 238000011226 adjuvant chemotherapy Methods 0.000 claims description 12
- 238000009396 hybridization Methods 0.000 claims description 11
- 239000002299 complementary DNA Substances 0.000 claims description 10
- 230000003247 decreasing effect Effects 0.000 claims description 8
- 239000011541 reaction mixture Substances 0.000 claims description 6
- 230000002349 favourable effect Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000000090 biomarker Substances 0.000 claims description 3
- 239000012502 diagnostic product Substances 0.000 claims description 3
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940041181 antineoplastic drug Drugs 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 abstract description 43
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 43
- 102100038147 Histone chaperone ASF1B Human genes 0.000 description 473
- 101000884473 Homo sapiens Histone chaperone ASF1B Proteins 0.000 description 473
- 102100022117 Abnormal spindle-like microcephaly-associated protein Human genes 0.000 description 126
- 101000900939 Homo sapiens Abnormal spindle-like microcephaly-associated protein Proteins 0.000 description 126
- ZPCCSZFPOXBNDL-ZSTSFXQOSA-N [(4r,5s,6s,7r,9r,10r,11e,13e,16r)-6-[(2s,3r,4r,5s,6r)-5-[(2s,4r,5s,6s)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2r,5s,6r)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoe Chemical compound O([C@H]1/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]([C@@H]([C@H]([C@@H](CC=O)C[C@H]1C)O[C@H]1[C@@H]([C@H]([C@H](O[C@@H]2O[C@@H](C)[C@H](O)[C@](C)(O)C2)[C@@H](C)O1)N(C)C)O)OC)OC(C)=O)[C@H]1CC[C@H](N(C)C)[C@@H](C)O1 ZPCCSZFPOXBNDL-ZSTSFXQOSA-N 0.000 description 126
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 99
- 108010002687 Survivin Proteins 0.000 description 99
- 101000794228 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Proteins 0.000 description 95
- 102100030144 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta Human genes 0.000 description 95
- 102400000112 Katacalcin Human genes 0.000 description 88
- 102100024829 DNA polymerase delta catalytic subunit Human genes 0.000 description 77
- 101000868333 Homo sapiens Cyclin-dependent kinase 1 Proteins 0.000 description 77
- 101000909198 Homo sapiens DNA polymerase delta catalytic subunit Proteins 0.000 description 77
- 102100024486 Borealin Human genes 0.000 description 75
- 108700020472 CDC20 Proteins 0.000 description 75
- 101150023302 Cdc20 gene Proteins 0.000 description 75
- 102100038099 Cell division cycle protein 20 homolog Human genes 0.000 description 75
- 102100036329 Cyclin-dependent kinase 3 Human genes 0.000 description 75
- 101000762405 Homo sapiens Borealin Proteins 0.000 description 75
- 101000945639 Homo sapiens Cyclin-dependent kinase inhibitor 3 Proteins 0.000 description 75
- 108010000598 Polycomb Repressive Complex 1 Proteins 0.000 description 75
- 102100033947 Protein regulator of cytokinesis 1 Human genes 0.000 description 75
- 101100010298 Schizosaccharomyces pombe (strain 972 / ATCC 24843) pol2 gene Proteins 0.000 description 75
- 102100023344 Centromere protein F Human genes 0.000 description 74
- 102100037980 Disks large-associated protein 5 Human genes 0.000 description 74
- 101000907941 Homo sapiens Centromere protein F Proteins 0.000 description 74
- 101000951365 Homo sapiens Disks large-associated protein 5 Proteins 0.000 description 74
- 102100033587 DNA topoisomerase 2-alpha Human genes 0.000 description 73
- 108010046308 Type II DNA Topoisomerases Proteins 0.000 description 73
- 101000968287 Homo sapiens Denticleless protein homolog Proteins 0.000 description 72
- 101000991410 Homo sapiens Nucleolar and spindle-associated protein 1 Proteins 0.000 description 72
- 101000585555 Homo sapiens PCNA-associated factor Proteins 0.000 description 72
- 101000575639 Homo sapiens Ribonucleoside-diphosphate reductase subunit M2 Proteins 0.000 description 72
- 102100030991 Nucleolar and spindle-associated protein 1 Human genes 0.000 description 72
- 102100029879 PCNA-associated factor Human genes 0.000 description 72
- 102100026006 Ribonucleoside-diphosphate reductase subunit M2 Human genes 0.000 description 72
- 102100024479 Cell division cycle-associated protein 3 Human genes 0.000 description 71
- 101000980907 Homo sapiens Cell division cycle-associated protein 3 Proteins 0.000 description 71
- 101001027621 Homo sapiens Kinesin-like protein KIF20A Proteins 0.000 description 71
- 101001087372 Homo sapiens Securin Proteins 0.000 description 71
- 102100037694 Kinesin-like protein KIF20A Human genes 0.000 description 71
- 102100033004 Securin Human genes 0.000 description 71
- 102100034838 Thymidine kinase, cytosolic Human genes 0.000 description 71
- 102100035366 Centromere protein M Human genes 0.000 description 70
- 102100031219 Centrosomal protein of 55 kDa Human genes 0.000 description 70
- 101000737696 Homo sapiens Centromere protein M Proteins 0.000 description 70
- 101000712511 Homo sapiens DNA repair and recombination protein RAD54-like Proteins 0.000 description 70
- 108010068097 Rad51 Recombinase Proteins 0.000 description 70
- 102000002490 Rad51 Recombinase Human genes 0.000 description 70
- 102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 description 70
- 102100023931 Transcriptional regulator ATRX Human genes 0.000 description 70
- 108010056274 polo-like kinase 1 Proteins 0.000 description 70
- 101710092479 Centrosomal protein of 55 kDa Proteins 0.000 description 69
- 101000825632 Homo sapiens Spindle and kinetochore-associated protein 1 Proteins 0.000 description 69
- 102100022915 Spindle and kinetochore-associated protein 1 Human genes 0.000 description 69
- 101001008953 Homo sapiens Kinesin-like protein KIF11 Proteins 0.000 description 68
- 101000721146 Homo sapiens Origin recognition complex subunit 6 Proteins 0.000 description 68
- 102100027629 Kinesin-like protein KIF11 Human genes 0.000 description 68
- 102100025201 Origin recognition complex subunit 6 Human genes 0.000 description 68
- 101000583797 Homo sapiens Protein MCM10 homolog Proteins 0.000 description 63
- 102100030962 Protein MCM10 homolog Human genes 0.000 description 63
- 230000004083 survival effect Effects 0.000 description 48
- 108700021031 cdc Genes Proteins 0.000 description 46
- 108010008599 Forkhead Box Protein M1 Proteins 0.000 description 42
- 102100023374 Forkhead box protein M1 Human genes 0.000 description 42
- 102100021215 Denticleless protein homolog Human genes 0.000 description 29
- 101001046554 Dictyostelium discoideum Thymidine kinase 1 Proteins 0.000 description 28
- 101000762967 Homo sapiens Lymphokine-activated killer T-cell-originated protein kinase Proteins 0.000 description 28
- 101000945477 Homo sapiens Thymidine kinase, cytosolic Proteins 0.000 description 28
- 102100026753 Lymphokine-activated killer T-cell-originated protein kinase Human genes 0.000 description 28
- 230000001575 pathological effect Effects 0.000 description 28
- 230000000694 effects Effects 0.000 description 19
- -1 rRNA Proteins 0.000 description 19
- 238000009098 adjuvant therapy Methods 0.000 description 18
- 238000003556 assay Methods 0.000 description 17
- 108091034117 Oligonucleotide Proteins 0.000 description 16
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 14
- 208000002458 carcinoid tumor Diseases 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 13
- 230000008901 benefit Effects 0.000 description 13
- 230000022131 cell cycle Effects 0.000 description 13
- 210000004072 lung Anatomy 0.000 description 13
- 230000006870 function Effects 0.000 description 12
- 102000004169 proteins and genes Human genes 0.000 description 12
- 238000003860 storage Methods 0.000 description 12
- 230000002596 correlated effect Effects 0.000 description 11
- 230000003993 interaction Effects 0.000 description 11
- 150000007523 nucleic acids Chemical class 0.000 description 11
- 210000004027 cell Anatomy 0.000 description 10
- 102000039446 nucleic acids Human genes 0.000 description 10
- 108020004707 nucleic acids Proteins 0.000 description 10
- 238000007473 univariate analysis Methods 0.000 description 10
- 102100020736 Chromosome-associated kinesin KIF4A Human genes 0.000 description 9
- 101001139157 Homo sapiens Chromosome-associated kinesin KIF4A Proteins 0.000 description 9
- 238000004891 communication Methods 0.000 description 9
- 238000001514 detection method Methods 0.000 description 9
- 230000000391 smoking effect Effects 0.000 description 9
- 210000001519 tissue Anatomy 0.000 description 9
- 238000012549 training Methods 0.000 description 9
- 102100033201 G2/mitotic-specific cyclin-B2 Human genes 0.000 description 8
- 101000713023 Homo sapiens G2/mitotic-specific cyclin-B2 Proteins 0.000 description 8
- 101000830894 Homo sapiens Targeting protein for Xklp2 Proteins 0.000 description 8
- 102100024813 Targeting protein for Xklp2 Human genes 0.000 description 8
- 238000000491 multivariate analysis Methods 0.000 description 8
- 238000001356 surgical procedure Methods 0.000 description 8
- 230000009545 invasion Effects 0.000 description 7
- 108020004414 DNA Proteins 0.000 description 6
- 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 description 6
- 101000868643 Homo sapiens G2/mitotic-specific cyclin-B1 Proteins 0.000 description 6
- 101001050567 Homo sapiens Kinesin-like protein KIF2C Proteins 0.000 description 6
- 102100023424 Kinesin-like protein KIF2C Human genes 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 101000743863 Homo sapiens ZW10 interactor Proteins 0.000 description 5
- 206010027476 Metastases Diseases 0.000 description 5
- 102100039102 ZW10 interactor Human genes 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 230000000875 corresponding effect Effects 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 230000036961 partial effect Effects 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 238000012163 sequencing technique Methods 0.000 description 5
- 230000000007 visual effect Effects 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- QYAPHLRPFNSDNH-MRFRVZCGSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride Chemical compound Cl.C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O QYAPHLRPFNSDNH-MRFRVZCGSA-N 0.000 description 4
- 102100022644 26S proteasome regulatory subunit 4 Human genes 0.000 description 4
- 102100022289 60S ribosomal protein L13a Human genes 0.000 description 4
- 102100040131 60S ribosomal protein L37 Human genes 0.000 description 4
- 102100030982 60S ribosomal protein L38 Human genes 0.000 description 4
- 102100026926 60S ribosomal protein L4 Human genes 0.000 description 4
- 102100035931 60S ribosomal protein L8 Human genes 0.000 description 4
- 238000012935 Averaging Methods 0.000 description 4
- 102100025053 Cell division control protein 45 homolog Human genes 0.000 description 4
- 102100026127 Clathrin heavy chain 1 Human genes 0.000 description 4
- 102100023470 Cobalamin trafficking protein CblD Human genes 0.000 description 4
- 102100032522 Cyclin-dependent kinases regulatory subunit 2 Human genes 0.000 description 4
- 102100033711 DNA replication licensing factor MCM7 Human genes 0.000 description 4
- 101100127296 Dictyostelium discoideum kif1 gene Proteins 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 101000619137 Homo sapiens 26S proteasome regulatory subunit 4 Proteins 0.000 description 4
- 101000681240 Homo sapiens 60S ribosomal protein L13a Proteins 0.000 description 4
- 101000671735 Homo sapiens 60S ribosomal protein L37 Proteins 0.000 description 4
- 101001127039 Homo sapiens 60S ribosomal protein L38 Proteins 0.000 description 4
- 101000691203 Homo sapiens 60S ribosomal protein L4 Proteins 0.000 description 4
- 101000853659 Homo sapiens 60S ribosomal protein L8 Proteins 0.000 description 4
- 101000934421 Homo sapiens Cell division control protein 45 homolog Proteins 0.000 description 4
- 101000912851 Homo sapiens Clathrin heavy chain 1 Proteins 0.000 description 4
- 101000977167 Homo sapiens Cobalamin trafficking protein CblD Proteins 0.000 description 4
- 101000942317 Homo sapiens Cyclin-dependent kinases regulatory subunit 2 Proteins 0.000 description 4
- 101001018431 Homo sapiens DNA replication licensing factor MCM7 Proteins 0.000 description 4
- 101001081176 Homo sapiens Hyaluronan mediated motility receptor Proteins 0.000 description 4
- 101000605743 Homo sapiens Kinesin-like protein KIF23 Proteins 0.000 description 4
- 101000593405 Homo sapiens Myb-related protein B Proteins 0.000 description 4
- 101001098930 Homo sapiens Pachytene checkpoint protein 2 homolog Proteins 0.000 description 4
- 101000736929 Homo sapiens Proteasome subunit alpha type-1 Proteins 0.000 description 4
- 101001068027 Homo sapiens Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Proteins 0.000 description 4
- 101000831940 Homo sapiens Stathmin Proteins 0.000 description 4
- 101000796121 Homo sapiens Thioredoxin-like protein 1 Proteins 0.000 description 4
- 101000840051 Homo sapiens Ubiquitin-60S ribosomal protein L40 Proteins 0.000 description 4
- 101000837565 Homo sapiens Ubiquitin-conjugating enzyme E2 S Proteins 0.000 description 4
- 102100027735 Hyaluronan mediated motility receptor Human genes 0.000 description 4
- 238000010824 Kaplan-Meier survival analysis Methods 0.000 description 4
- 102100038406 Kinesin-like protein KIF23 Human genes 0.000 description 4
- 101100127288 Mus musculus Kif1a gene Proteins 0.000 description 4
- 102100034670 Myb-related protein B Human genes 0.000 description 4
- 102100038993 Pachytene checkpoint protein 2 homolog Human genes 0.000 description 4
- 102100036042 Proteasome subunit alpha type-1 Human genes 0.000 description 4
- 102100034464 Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform Human genes 0.000 description 4
- 102100024237 Stathmin Human genes 0.000 description 4
- 102100031373 Thioredoxin-like protein 1 Human genes 0.000 description 4
- 102100028462 Ubiquitin-60S ribosomal protein L40 Human genes 0.000 description 4
- 102100028718 Ubiquitin-conjugating enzyme E2 S Human genes 0.000 description 4
- 208000009956 adenocarcinoma Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 4
- 101150103259 ccp gene Proteins 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 239000003550 marker Substances 0.000 description 4
- 238000002493 microarray Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000013610 patient sample Substances 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 102100040685 14-3-3 protein zeta/delta Human genes 0.000 description 3
- 102100026031 Beta-glucuronidase Human genes 0.000 description 3
- 102100027047 Cell division control protein 6 homolog Human genes 0.000 description 3
- 108010076303 Centromere Protein A Proteins 0.000 description 3
- 102000011682 Centromere Protein A Human genes 0.000 description 3
- 102100032951 Condensin complex subunit 2 Human genes 0.000 description 3
- 102100032952 Condensin complex subunit 3 Human genes 0.000 description 3
- 102100032980 Condensin-2 complex subunit G2 Human genes 0.000 description 3
- 102100025191 Cyclin-A2 Human genes 0.000 description 3
- 102100040262 DNA dC->dU-editing enzyme APOBEC-3B Human genes 0.000 description 3
- 102100027564 DNA replication complex GINS protein PSF1 Human genes 0.000 description 3
- 102100021389 DNA replication licensing factor MCM4 Human genes 0.000 description 3
- 101000964898 Homo sapiens 14-3-3 protein zeta/delta Proteins 0.000 description 3
- 101000933465 Homo sapiens Beta-glucuronidase Proteins 0.000 description 3
- 101000914465 Homo sapiens Cell division control protein 6 homolog Proteins 0.000 description 3
- 101000942617 Homo sapiens Condensin complex subunit 2 Proteins 0.000 description 3
- 101000942622 Homo sapiens Condensin complex subunit 3 Proteins 0.000 description 3
- 101000942591 Homo sapiens Condensin-2 complex subunit G2 Proteins 0.000 description 3
- 101000934320 Homo sapiens Cyclin-A2 Proteins 0.000 description 3
- 101000964385 Homo sapiens DNA dC->dU-editing enzyme APOBEC-3B Proteins 0.000 description 3
- 101001080484 Homo sapiens DNA replication complex GINS protein PSF1 Proteins 0.000 description 3
- 101000615280 Homo sapiens DNA replication licensing factor MCM4 Proteins 0.000 description 3
- 101001130243 Homo sapiens RAD51-associated protein 1 Proteins 0.000 description 3
- 101001096541 Homo sapiens Rac GTPase-activating protein 1 Proteins 0.000 description 3
- 101000582914 Homo sapiens Serine/threonine-protein kinase PLK4 Proteins 0.000 description 3
- 101000809797 Homo sapiens Thymidylate synthase Proteins 0.000 description 3
- 101000836150 Homo sapiens Transforming acidic coiled-coil-containing protein 3 Proteins 0.000 description 3
- 101000807354 Homo sapiens Ubiquitin-conjugating enzyme E2 C Proteins 0.000 description 3
- 102100035692 Importin subunit alpha-1 Human genes 0.000 description 3
- 102100024299 Maternal embryonic leucine zipper kinase Human genes 0.000 description 3
- 101710154611 Maternal embryonic leucine zipper kinase Proteins 0.000 description 3
- 102100037935 Polyubiquitin-C Human genes 0.000 description 3
- 102100034391 Porphobilinogen deaminase Human genes 0.000 description 3
- 102100031535 RAD51-associated protein 1 Human genes 0.000 description 3
- 102100037414 Rac GTPase-activating protein 1 Human genes 0.000 description 3
- 102100030267 Serine/threonine-protein kinase PLK4 Human genes 0.000 description 3
- 102100038618 Thymidylate synthase Human genes 0.000 description 3
- 102100027048 Transforming acidic coiled-coil-containing protein 3 Human genes 0.000 description 3
- 108010056354 Ubiquitin C Proteins 0.000 description 3
- 102100037256 Ubiquitin-conjugating enzyme E2 C Human genes 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 238000003491 array Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 101150090413 cu gene Proteins 0.000 description 3
- 230000002068 genetic effect Effects 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 108010011989 karyopherin alpha 2 Proteins 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 3
- 238000010200 validation analysis Methods 0.000 description 3
- PJOHVEQSYPOERL-SHEAVXILSA-N (e)-n-[(4r,4as,7ar,12br)-3-(cyclopropylmethyl)-9-hydroxy-7-oxo-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-4a-yl]-3-(4-methylphenyl)prop-2-enamide Chemical compound C1=CC(C)=CC=C1\C=C\C(=O)N[C@]1(CCC(=O)[C@@H]2O3)[C@H]4CC5=CC=C(O)C3=C5[C@]12CCN4CC1CC1 PJOHVEQSYPOERL-SHEAVXILSA-N 0.000 description 2
- DIDGPCDGNMIUNX-UUOKFMHZSA-N 2-amino-9-[(2r,3r,4s,5r)-5-(dihydroxyphosphinothioyloxymethyl)-3,4-dihydroxyoxolan-2-yl]-3h-purin-6-one Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(O)=S)[C@@H](O)[C@H]1O DIDGPCDGNMIUNX-UUOKFMHZSA-N 0.000 description 2
- 102100031928 40S ribosomal protein S29 Human genes 0.000 description 2
- 101150039504 6 gene Proteins 0.000 description 2
- 102100034402 ATP-dependent RNA helicase DDX39A Human genes 0.000 description 2
- 102100039864 ATPase family AAA domain-containing protein 2 Human genes 0.000 description 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 102000004000 Aurora Kinase A Human genes 0.000 description 2
- 108090000461 Aurora Kinase A Proteins 0.000 description 2
- 101710083734 CTP synthase Proteins 0.000 description 2
- 102100039866 CTP synthase 1 Human genes 0.000 description 2
- 102100026540 Cathepsin L2 Human genes 0.000 description 2
- 102100023126 Cell surface glycoprotein MUC18 Human genes 0.000 description 2
- 102100023343 Centromere protein I Human genes 0.000 description 2
- 102100031214 Centromere protein N Human genes 0.000 description 2
- 102100025832 Centromere-associated protein E Human genes 0.000 description 2
- 101001025006 Coelastrella vacuolata Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic Proteins 0.000 description 2
- 102100033843 Condensin complex subunit 1 Human genes 0.000 description 2
- 108050006400 Cyclin Proteins 0.000 description 2
- 102100028630 Cytoskeleton-associated protein 2 Human genes 0.000 description 2
- 102100029910 DNA polymerase epsilon subunit 2 Human genes 0.000 description 2
- 102100034490 DNA repair and recombination protein RAD54B Human genes 0.000 description 2
- 102100033720 DNA replication licensing factor MCM6 Human genes 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 102100023941 G-protein-signaling modulator 2 Human genes 0.000 description 2
- 102100037858 G1/S-specific cyclin-E1 Human genes 0.000 description 2
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 2
- 102100034533 Histone H2AX Human genes 0.000 description 2
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 description 2
- 101000704060 Homo sapiens 40S ribosomal protein S29 Proteins 0.000 description 2
- 101000923749 Homo sapiens ATP-dependent RNA helicase DDX39A Proteins 0.000 description 2
- 101000887284 Homo sapiens ATPase family AAA domain-containing protein 2 Proteins 0.000 description 2
- 101000983577 Homo sapiens Cathepsin L2 Proteins 0.000 description 2
- 101000623903 Homo sapiens Cell surface glycoprotein MUC18 Proteins 0.000 description 2
- 101000907944 Homo sapiens Centromere protein I Proteins 0.000 description 2
- 101000776412 Homo sapiens Centromere protein N Proteins 0.000 description 2
- 101000914247 Homo sapiens Centromere-associated protein E Proteins 0.000 description 2
- 101000710846 Homo sapiens Condensin complex subunit 1 Proteins 0.000 description 2
- 101000766848 Homo sapiens Cytoskeleton-associated protein 2 Proteins 0.000 description 2
- 101000864190 Homo sapiens DNA polymerase epsilon subunit 2 Proteins 0.000 description 2
- 101001132263 Homo sapiens DNA repair and recombination protein RAD54B Proteins 0.000 description 2
- 101000583807 Homo sapiens DNA replication licensing factor MCM2 Proteins 0.000 description 2
- 101001018484 Homo sapiens DNA replication licensing factor MCM6 Proteins 0.000 description 2
- 101000904754 Homo sapiens G-protein-signaling modulator 2 Proteins 0.000 description 2
- 101000738568 Homo sapiens G1/S-specific cyclin-E1 Proteins 0.000 description 2
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 2
- 101001067891 Homo sapiens Histone H2AX Proteins 0.000 description 2
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 2
- 101001008951 Homo sapiens Kinesin-like protein KIF15 Proteins 0.000 description 2
- 101001027631 Homo sapiens Kinesin-like protein KIF20B Proteins 0.000 description 2
- 101001112162 Homo sapiens Kinetochore protein NDC80 homolog Proteins 0.000 description 2
- 101000987090 Homo sapiens MORF4 family-associated protein 1 Proteins 0.000 description 2
- 101000896657 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Proteins 0.000 description 2
- 101001081953 Homo sapiens Phosphoribosylaminoimidazole carboxylase Proteins 0.000 description 2
- 101000721172 Homo sapiens Protein DBF4 homolog A Proteins 0.000 description 2
- 101000817237 Homo sapiens Protein ECT2 Proteins 0.000 description 2
- 101000625256 Homo sapiens Protein Mis18-beta Proteins 0.000 description 2
- 101000618174 Homo sapiens Protein Spindly Proteins 0.000 description 2
- 101000863978 Homo sapiens Protein downstream neighbor of Son Proteins 0.000 description 2
- 101000743825 Homo sapiens Protein zwilch homolog Proteins 0.000 description 2
- 101001096365 Homo sapiens Replication factor C subunit 2 Proteins 0.000 description 2
- 101000582404 Homo sapiens Replication factor C subunit 4 Proteins 0.000 description 2
- 101000582412 Homo sapiens Replication factor C subunit 5 Proteins 0.000 description 2
- 101001103771 Homo sapiens Ribonuclease H2 subunit A Proteins 0.000 description 2
- 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 description 2
- 101000601441 Homo sapiens Serine/threonine-protein kinase Nek2 Proteins 0.000 description 2
- 101000618133 Homo sapiens Sperm-associated antigen 5 Proteins 0.000 description 2
- 101000633445 Homo sapiens Structural maintenance of chromosomes protein 2 Proteins 0.000 description 2
- 101000866298 Homo sapiens Transcription factor E2F8 Proteins 0.000 description 2
- 102100027630 Kinesin-like protein KIF15 Human genes 0.000 description 2
- 102100037691 Kinesin-like protein KIF20B Human genes 0.000 description 2
- 102100023890 Kinetochore protein NDC80 homolog Human genes 0.000 description 2
- 102100026519 Lamin-B2 Human genes 0.000 description 2
- 238000003657 Likelihood-ratio test Methods 0.000 description 2
- 102100027862 MORF4 family-associated protein 1 Human genes 0.000 description 2
- 102100021691 Mitotic checkpoint serine/threonine-protein kinase BUB1 Human genes 0.000 description 2
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 2
- 102100027330 Phosphoribosylaminoimidazole carboxylase Human genes 0.000 description 2
- 101710189720 Porphobilinogen deaminase Proteins 0.000 description 2
- 101710170827 Porphobilinogen deaminase, chloroplastic Proteins 0.000 description 2
- 101710100896 Probable porphobilinogen deaminase Proteins 0.000 description 2
- 102100036691 Proliferating cell nuclear antigen Human genes 0.000 description 2
- 102100025198 Protein DBF4 homolog A Human genes 0.000 description 2
- 102100040437 Protein ECT2 Human genes 0.000 description 2
- 102100025034 Protein Mis18-beta Human genes 0.000 description 2
- 102100021884 Protein Spindly Human genes 0.000 description 2
- 102100029926 Protein downstream neighbor of Son Human genes 0.000 description 2
- 102100039105 Protein zwilch homolog Human genes 0.000 description 2
- 238000002123 RNA extraction Methods 0.000 description 2
- 102100037851 Replication factor C subunit 2 Human genes 0.000 description 2
- 102100030542 Replication factor C subunit 4 Human genes 0.000 description 2
- 102100030541 Replication factor C subunit 5 Human genes 0.000 description 2
- 102100039493 Ribonuclease H2 subunit A Human genes 0.000 description 2
- 102100028029 SCL-interrupting locus protein Human genes 0.000 description 2
- 102000012152 Securin Human genes 0.000 description 2
- 108010061477 Securin Proteins 0.000 description 2
- 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 description 2
- 102100037703 Serine/threonine-protein kinase Nek2 Human genes 0.000 description 2
- 102100021915 Sperm-associated antigen 5 Human genes 0.000 description 2
- 102100029540 Structural maintenance of chromosomes protein 2 Human genes 0.000 description 2
- 229940123237 Taxane Drugs 0.000 description 2
- 102100031555 Transcription factor E2F8 Human genes 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 238000004422 calculation algorithm Methods 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 108010052219 lamin B2 Proteins 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 201000005249 lung adenocarcinoma Diseases 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 230000001394 metastastic effect Effects 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 239000002679 microRNA Substances 0.000 description 2
- 108091027963 non-coding RNA Proteins 0.000 description 2
- 102000042567 non-coding RNA Human genes 0.000 description 2
- 239000002853 nucleic acid probe Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 238000003753 real-time PCR Methods 0.000 description 2
- 238000002271 resection Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- WZUVPPKBWHMQCE-XJKSGUPXSA-N (+)-haematoxylin Chemical compound C12=CC(O)=C(O)C=C2C[C@]2(O)[C@H]1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-XJKSGUPXSA-N 0.000 description 1
- YXTKHLHCVFUPPT-YYFJYKOTSA-N (2s)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid;(1r,2r)-1,2-dimethanidylcyclohexane;5-fluoro-1h-pyrimidine-2,4-dione;oxalic acid;platinum(2+) Chemical compound [Pt+2].OC(=O)C(O)=O.[CH2-][C@@H]1CCCC[C@H]1[CH2-].FC1=CNC(=O)NC1=O.C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 YXTKHLHCVFUPPT-YYFJYKOTSA-N 0.000 description 1
- 101150066838 12 gene Proteins 0.000 description 1
- 101150022407 124 gene Proteins 0.000 description 1
- 101150025032 13 gene Proteins 0.000 description 1
- 101150082072 14 gene Proteins 0.000 description 1
- 101150029062 15 gene Proteins 0.000 description 1
- 101150076401 16 gene Proteins 0.000 description 1
- 101150016096 17 gene Proteins 0.000 description 1
- 101150078635 18 gene Proteins 0.000 description 1
- 101150040471 19 gene Proteins 0.000 description 1
- 101150028074 2 gene Proteins 0.000 description 1
- 101150112497 26 gene Proteins 0.000 description 1
- 102100036563 26S proteasome regulatory subunit 8 Human genes 0.000 description 1
- 108700036240 26S proteasome regulatory subunit 8 Proteins 0.000 description 1
- 101150090724 3 gene Proteins 0.000 description 1
- 101150070234 31 gene Proteins 0.000 description 1
- 101150033839 4 gene Proteins 0.000 description 1
- 101150096316 5 gene Proteins 0.000 description 1
- 101150101112 7 gene Proteins 0.000 description 1
- 102100022299 All trans-polyprenyl-diphosphate synthase PDSS1 Human genes 0.000 description 1
- 102100032311 Aurora kinase A Human genes 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 101100326430 Caenorhabditis elegans bub-1 gene Proteins 0.000 description 1
- 101100005986 Caenorhabditis elegans cth-2 gene Proteins 0.000 description 1
- 102100034501 Cyclin-dependent kinases regulatory subunit 1 Human genes 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- 238000009007 Diagnostic Kit Methods 0.000 description 1
- 101100181029 Dictyostelium discoideum kif2 gene Proteins 0.000 description 1
- 108010067770 Endopeptidase K Proteins 0.000 description 1
- 108010057573 Flavoproteins Proteins 0.000 description 1
- 102000003983 Flavoproteins Human genes 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
- 102100037488 G2 and S phase-expressed protein 1 Human genes 0.000 description 1
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Natural products C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 1
- 101000902409 Homo sapiens All trans-polyprenyl-diphosphate synthase PDSS1 Proteins 0.000 description 1
- 101000798300 Homo sapiens Aurora kinase A Proteins 0.000 description 1
- 101000710200 Homo sapiens Cyclin-dependent kinases regulatory subunit 1 Proteins 0.000 description 1
- 101001026457 Homo sapiens G2 and S phase-expressed protein 1 Proteins 0.000 description 1
- 101001091231 Homo sapiens Kinesin-like protein KIF18A Proteins 0.000 description 1
- 101001050577 Homo sapiens Kinesin-like protein KIF2A Proteins 0.000 description 1
- 101001006776 Homo sapiens Kinesin-like protein KIFC1 Proteins 0.000 description 1
- 101000711455 Homo sapiens Kinetochore protein Spc25 Proteins 0.000 description 1
- 101001053809 Homo sapiens Kinetochore-associated protein DSN1 homolog Proteins 0.000 description 1
- 101000957259 Homo sapiens Mitotic spindle assembly checkpoint protein MAD2A Proteins 0.000 description 1
- 101001080624 Homo sapiens Proline/serine-rich coiled-coil protein 1 Proteins 0.000 description 1
- 101000863815 Homo sapiens SHC SH2 domain-binding protein 1 Proteins 0.000 description 1
- 101000649929 Homo sapiens Serine/threonine-protein kinase VRK1 Proteins 0.000 description 1
- 101000824035 Homo sapiens Serum response factor Proteins 0.000 description 1
- 101000596093 Homo sapiens Transcription initiation factor TFIID subunit 1 Proteins 0.000 description 1
- 101000838350 Homo sapiens Tubulin alpha-1C chain Proteins 0.000 description 1
- 108010056651 Hydroxymethylbilane synthase Proteins 0.000 description 1
- 229940126262 KIF18A Drugs 0.000 description 1
- 102100034895 Kinesin-like protein KIF18A Human genes 0.000 description 1
- 102100023426 Kinesin-like protein KIF2A Human genes 0.000 description 1
- 102100027942 Kinesin-like protein KIFC1 Human genes 0.000 description 1
- 102100024062 Kinetochore-associated protein DSN1 homolog Human genes 0.000 description 1
- 108700011259 MicroRNAs Proteins 0.000 description 1
- 102100038792 Mitotic spindle assembly checkpoint protein MAD2A Human genes 0.000 description 1
- 101100521334 Mus musculus Prom1 gene Proteins 0.000 description 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 108020002230 Pancreatic Ribonuclease Proteins 0.000 description 1
- 102000005891 Pancreatic ribonuclease Human genes 0.000 description 1
- 102100037170 Phosphate carrier protein, mitochondrial Human genes 0.000 description 1
- 108091007412 Piwi-interacting RNA Proteins 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 102100027427 Proline/serine-rich coiled-coil protein 1 Human genes 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 102100029989 SHC SH2 domain-binding protein 1 Human genes 0.000 description 1
- 108091006710 SLC25A3 Proteins 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 102100028235 Serine/threonine-protein kinase VRK1 Human genes 0.000 description 1
- 102100022056 Serum response factor Human genes 0.000 description 1
- 102100023776 Signal peptidase complex subunit 2 Human genes 0.000 description 1
- 108020003224 Small Nucleolar RNA Proteins 0.000 description 1
- 102000042773 Small Nucleolar RNA Human genes 0.000 description 1
- 108020004459 Small interfering RNA Proteins 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- 108010006785 Taq Polymerase Proteins 0.000 description 1
- 102100035222 Transcription initiation factor TFIID subunit 1 Human genes 0.000 description 1
- 102100028985 Tubulin alpha-1C chain Human genes 0.000 description 1
- 102000003431 Ubiquitin-Conjugating Enzyme Human genes 0.000 description 1
- 108060008747 Ubiquitin-Conjugating Enzyme Proteins 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- 229940045985 antineoplastic platinum compound Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 238000011237 bivariate analysis Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000005773 cancer-related death Effects 0.000 description 1
- 229960004562 carboplatin Drugs 0.000 description 1
- YAYRGNWWLMLWJE-UHFFFAOYSA-L carboplatin Chemical compound O=C1O[Pt](N)(N)OC(=O)C11CCC1 YAYRGNWWLMLWJE-UHFFFAOYSA-L 0.000 description 1
- 230000006369 cell cycle progression Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
- 229960004316 cisplatin Drugs 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 239000005547 deoxyribonucleotide Substances 0.000 description 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 229960003668 docetaxel Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 101150004703 eIF3i gene Proteins 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229960002949 fluorouracil Drugs 0.000 description 1
- JYEFSHLLTQIXIO-SMNQTINBSA-N folfiri regimen Chemical compound FC1=CNC(=O)NC1=O.C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 JYEFSHLLTQIXIO-SMNQTINBSA-N 0.000 description 1
- 239000012520 frozen sample Substances 0.000 description 1
- 238000012260 full gene deletion Methods 0.000 description 1
- 229960005277 gemcitabine Drugs 0.000 description 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
- 238000003633 gene expression assay Methods 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000003364 immunohistochemistry Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000001325 log-rank test Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
- 238000007069 methylation reaction Methods 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 238000010208 microarray analysis Methods 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 230000009022 nonlinear effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000002751 oligonucleotide probe Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229960001756 oxaliplatin Drugs 0.000 description 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 238000012259 partial gene deletion Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 150000003058 platinum compounds Chemical class 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000004055 small Interfering RNA Substances 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001755 vocal effect Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767490P | 2013-02-21 | 2013-02-21 | |
| US61/767,490 | 2013-02-21 | ||
| US201361860470P | 2013-07-31 | 2013-07-31 | |
| US61/860,470 | 2013-07-31 | ||
| US201361894733P | 2013-10-23 | 2013-10-23 | |
| US61/894,733 | 2013-10-23 | ||
| PCT/US2014/017706 WO2014130825A1 (en) | 2013-02-21 | 2014-02-21 | Gene signatures for lung cancer prognosis and therapy selection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2901761A1 true CA2901761A1 (en) | 2014-08-28 |
Family
ID=51391852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2901761A Abandoned CA2901761A1 (en) | 2013-02-21 | 2014-02-21 | Gene signatures for lung cancer prognosis and therapy selection |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20140315935A1 (enExample) |
| EP (1) | EP2958999A4 (enExample) |
| JP (1) | JP2016515800A (enExample) |
| CA (1) | CA2901761A1 (enExample) |
| WO (1) | WO2014130825A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE212013000295U1 (de) | 2013-05-06 | 2016-02-02 | Hitachi Chemical Co. America, Ltd. | Vorrichtungen zum Einfangen von Zielmolekülen |
| JP6730983B2 (ja) * | 2014-09-19 | 2020-07-29 | ザ プロボスト,フェローズ,ファウンデーション スカラーズ,アンド ジ アザー メンバーズ オブ ボード,オブ ザ カレッジ オブ ザ ホーリー アンド アンディブ.トリニティー オブ クイーン エリザベス,ニアー ダブリン | 癌の再発リスクを予測する方法 |
| WO2016077537A1 (en) * | 2014-11-12 | 2016-05-19 | Hitachi Chemical Co., Ltd. | Method and device for diagnosing organ injury |
| KR101825369B1 (ko) * | 2015-06-15 | 2018-02-06 | 강원대학교산학협력단 | 암의 예후 판단용 유전자 바이오 마커 및 이의 용도 |
| WO2017040520A1 (en) | 2015-08-31 | 2017-03-09 | Hitachi Chemical Co., Ltd. | Molecular methods for assessing urothelial disease |
| BR112021003095A2 (pt) * | 2018-08-20 | 2021-05-11 | Trustees Of Boston University | métodos relacionados à gravidade e progressão de lesão pré-maligna bronquial |
| CN111187833A (zh) * | 2018-11-14 | 2020-05-22 | 上海生物芯片有限公司 | Plk1和bub1b基因联合作为肺癌生物标志物的用途 |
| CN118782151B (zh) * | 2024-07-24 | 2025-08-29 | 西南医科大学附属医院 | 一种基于“靶点-药物加权积分制”构建脓毒症疾病关键靶点与药物筛选方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6809118B2 (en) * | 2002-07-25 | 2004-10-26 | Yih-Lin Chung | Methods for therapy of radiation cutaneous syndrome |
| EP3524697B1 (en) * | 2009-01-07 | 2024-10-02 | Myriad Genetics, Inc. | Cancer biomarkers |
| WO2012030840A2 (en) * | 2010-08-30 | 2012-03-08 | Myriad Genetics, Inc. | Gene signatures for cancer diagnosis and prognosis |
| CA2845568A1 (en) * | 2011-08-19 | 2013-02-28 | Myriad Genetics, Inc. | Gene signatures for lung cancer prognosis and therapy selection |
-
2014
- 2014-02-21 US US14/186,290 patent/US20140315935A1/en not_active Abandoned
- 2014-02-21 WO PCT/US2014/017706 patent/WO2014130825A1/en not_active Ceased
- 2014-02-21 JP JP2015558997A patent/JP2016515800A/ja active Pending
- 2014-02-21 CA CA2901761A patent/CA2901761A1/en not_active Abandoned
- 2014-02-21 EP EP14754889.5A patent/EP2958999A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP2958999A4 (en) | 2016-10-19 |
| EP2958999A1 (en) | 2015-12-30 |
| US20140315935A1 (en) | 2014-10-23 |
| JP2016515800A (ja) | 2016-06-02 |
| WO2014130825A1 (en) | 2014-08-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20140170242A1 (en) | Gene signatures for lung cancer prognosis and therapy selection | |
| US20140315935A1 (en) | Gene signatures for lung cancer prognosis and therapy selection | |
| US20160024596A1 (en) | Prognostic and Predictive Gene Signature for Non-Small Cell Lung Cancer and Adjuvant Chemotherapy | |
| US11834719B2 (en) | Genes and gene signatures for diagnosis and treatement of melanoma | |
| US20140170139A1 (en) | Hypoxia-related gene signatures for cancer classification | |
| AU2022200004B2 (en) | Genes and gene signatures for diagnosis and treatment of melanoma | |
| WO2014066796A2 (en) | Breast cancer prognosis signatures | |
| US20170137890A1 (en) | Cancer prognosis signatures | |
| CA2839846A1 (en) | Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy | |
| WO2017193062A1 (en) | Gene signatures for renal cancer prognosis | |
| US20140212415A1 (en) | Hypoxia-related gene signatures for cancer classification | |
| CA2813257A1 (en) | Brca deficiency and methods of use | |
| WO2013109690A1 (en) | Breast cancer prognosis signatures | |
| US20160281177A1 (en) | Gene signatures for renal cancer prognosis | |
| US20140024028A1 (en) | Brca deficiency and methods of use | |
| US20220243275A1 (en) | Genes and gene signature for diagnosis and treatment of melanoma |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20190221 |