CA2901439C - Peptides for use in the topical treatment of retinal neurodegenerative diseases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role - Google Patents

Peptides for use in the topical treatment of retinal neurodegenerative diseases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role Download PDF

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Publication number
CA2901439C
CA2901439C CA2901439A CA2901439A CA2901439C CA 2901439 C CA2901439 C CA 2901439C CA 2901439 A CA2901439 A CA 2901439A CA 2901439 A CA2901439 A CA 2901439A CA 2901439 C CA2901439 C CA 2901439C
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Prior art keywords
peptide
amino acid
use according
group
acid sequence
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CA2901439A
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English (en)
French (fr)
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CA2901439A1 (en
Inventor
Rafael Simo Canonge
Cristina Hernandez Pascual
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fundacio Institut de Recerca Hospital Universitari Vall dHebron
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Fundacio Institut de Recerca Hospital Universitari Vall dHebron
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Publication of CA2901439A1 publication Critical patent/CA2901439A1/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA2901439A 2013-03-01 2014-02-27 Peptides for use in the topical treatment of retinal neurodegenerative diseases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role Active CA2901439C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13382063 2013-03-01
EP13382063.9 2013-03-01
PCT/EP2014/053787 WO2014131815A1 (en) 2013-03-01 2014-02-27 Peptides for use in the topical treatment of retinal neurodegenerative disesases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role

Publications (2)

Publication Number Publication Date
CA2901439A1 CA2901439A1 (en) 2014-09-04
CA2901439C true CA2901439C (en) 2023-04-04

Family

ID=47901927

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2901439A Active CA2901439C (en) 2013-03-01 2014-02-27 Peptides for use in the topical treatment of retinal neurodegenerative diseases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role

Country Status (14)

Country Link
US (1) US9707273B2 (OSRAM)
EP (1) EP2968471B1 (OSRAM)
JP (2) JP6368722B2 (OSRAM)
CN (1) CN105007931B (OSRAM)
CA (1) CA2901439C (OSRAM)
DK (1) DK2968471T3 (OSRAM)
ES (1) ES2644016T3 (OSRAM)
HR (1) HRP20171501T1 (OSRAM)
HU (1) HUE036542T2 (OSRAM)
MX (1) MX364911B (OSRAM)
PL (1) PL2968471T3 (OSRAM)
PT (1) PT2968471T (OSRAM)
SI (1) SI2968471T1 (OSRAM)
WO (1) WO2014131815A1 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015026910A2 (pt) 2013-04-23 2017-07-25 Procter & Gamble arranjo de ferramenta para consulta de cabelo e método
ES2949095T3 (es) 2014-12-12 2023-09-25 Sanofi Aventis Deutschland Formulación de relación fija de insulina glargina/lixisenatida
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第2型糖尿病病患之治療
KR102508651B1 (ko) 2015-12-23 2023-03-13 더 존스 홉킨스 유니버시티 신경계 및 신경변성 상태의 요법으로서 장기간 작용하는 glf-1r 작용제
ES2903397T3 (es) 2015-12-30 2022-04-01 Marshall Univ Research Corporation Composiciones y métodos para tratar la retinopatía
DK3448388T3 (da) * 2016-04-29 2021-02-08 Fundacio Hospital Univ Vall D Hebron Institut De Recerca Dipeptidyl-peptidase-4-inhibitorer til topikal øjenbehandling af retinale neurodegenerative sygdomme
CN106822182A (zh) * 2016-12-27 2017-06-13 广州姿生生物科技有限公司 一种细胞提取物及其用途
EP3443980A1 (en) * 2017-08-15 2019-02-20 Ciliocure Limited Compound for the treatment of patients with leptin-resistant obesity, bardet-biedl syndrome and other ciliopathies
BR112022014543A2 (pt) 2020-02-13 2022-09-20 Ferrer Int Composição farmacêutica oftálmica e uso da mesma
GB202014740D0 (en) * 2020-09-18 2020-11-04 Invex Therapeutics Ltd Method of reducing intraocular pressure
US20220193201A1 (en) * 2020-10-19 2022-06-23 The Trustees Of The University Of Pennsylvania Glp-1r agonist reduces retinal inflammation and neuron death secondary to ocular hypertension
EP4240391A4 (en) * 2020-11-09 2024-09-11 Tel HaShomer Medical Research Infrastructure and Services Ltd. TREATMENT OF RETINAL DISORDERS
EP4248985A1 (en) 2022-03-25 2023-09-27 Consejo Superior de Investigaciones Científicas (CSIC) Peptides for the treatment of retinitis pigmentosa

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
JP3149958B2 (ja) 1996-08-30 2001-03-26 ノボ ノルディスク アクティーゼルスカブ Glp―1誘導体
WO1998030231A1 (en) 1997-01-07 1998-07-16 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the reduction of food intake
WO2003059373A2 (en) 2002-01-16 2003-07-24 Ramot At Tel Aviv University Ltd. Compositions and their use for enhancing and inhibiting fertilization
US20120021980A1 (en) 2004-08-25 2012-01-26 Aegis Therapeutics, Inc. Compositions for drug administration
US8541413B2 (en) 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
WO2007062434A2 (en) 2005-11-22 2007-05-31 Crestwave Technologies (Pty) Ltd A mineral recovery process
US8362050B2 (en) * 2008-06-24 2013-01-29 Irm Llc Compounds and methods for modulating G protein-coupled receptors
EP2251028A1 (en) * 2009-05-12 2010-11-17 Biocompatibles Uk Ltd. Treatment of eye diseases using encapsulated cells encoding and secreting an anti-angiogenic factor and/or a neuroprotective factor
ES2362604B1 (es) 2009-12-22 2012-06-28 Bcn Peptides, S.A. Formulación tópica oftálmica de péptidos.
CN102643339B (zh) * 2011-02-21 2014-04-09 天津药物研究院 一种glp-1类似物、制备方法及其应用

Also Published As

Publication number Publication date
CN105007931A (zh) 2015-10-28
JP6368722B2 (ja) 2018-08-01
US20160000882A1 (en) 2016-01-07
PL2968471T3 (pl) 2017-12-29
BR112015020143A2 (pt) 2017-08-29
WO2014131815A1 (en) 2014-09-04
HUE036542T2 (hu) 2018-07-30
SI2968471T1 (sl) 2017-11-30
EP2968471A1 (en) 2016-01-20
JP2018111702A (ja) 2018-07-19
DK2968471T3 (en) 2017-10-23
JP2016510728A (ja) 2016-04-11
MX364911B (es) 2019-05-13
CN105007931B (zh) 2018-04-06
ES2644016T3 (es) 2017-11-27
US9707273B2 (en) 2017-07-18
EP2968471B1 (en) 2017-07-19
PT2968471T (pt) 2017-10-24
MX2015011243A (es) 2016-04-25
HRP20171501T1 (hr) 2017-11-17
CA2901439A1 (en) 2014-09-04

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