CA2899814A1 - Methods of skin whitening by use of canola extracts - Google Patents
Methods of skin whitening by use of canola extracts Download PDFInfo
- Publication number
- CA2899814A1 CA2899814A1 CA2899814A CA2899814A CA2899814A1 CA 2899814 A1 CA2899814 A1 CA 2899814A1 CA 2899814 A CA2899814 A CA 2899814A CA 2899814 A CA2899814 A CA 2899814A CA 2899814 A1 CA2899814 A1 CA 2899814A1
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- CA
- Canada
- Prior art keywords
- acid
- canola extract
- extract comprises
- skin
- canola
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Compositions and methods for lightening skin are provided. A method for lightening skin may include the step of identifying skin where lightening or whitening is desired and topically applying to the skin a composition including (a) a skin lightening agent comprising a canola extract and (b) a cosmetically acceptable carrier. A method for treating hyperpigmentation may include the step of identifying skin containing areas of hyperpigmentation and topically applying to the skin a composition including (a) a canola extract and (b) a cosmetically acceptable carrier.
Description
METHODS OF SKIN WHITENING BY USE OF CANOLA EXTRACTS
FIELD OF THE INVENTION
The present invention relates generally to compositions of canola extracts containing high levels of phenolic acids and their methods of use to whiten skin.
BACKGROUND
In humans, melanin is the primary determinant of skin color. In the skin, specialized cells found in the basal layer of the dermis called melanocytes, produce melanin. Human possess similar concentrations of melanocytes in their skin, but present different concentrations of skin melanin based on their ethnicity.
Melanin plays an important biological role as a photoprotectant because it absorbs harmful UV radiation and transforms that energy into harmless heat. This property enables melanin to dissipate more than 99.9% of the absorbed UV radiation as heat.
Melanogenesis, or increased production of melanin in human skin, is stimulated by UVB-radiation to produce what is commonly known as a tan. Although a tan appearance is desired by some people in various cultures, some cultures desire a lighter skin appearance. Further, melanin pigment disorders are perceived as cosmetic flaws. Examples of these local hyperpigmentations would be: freckles, melasma, chloasma, post-inflammatory hyperpigmentation, liver spots and many more. It is common to all forms of hyperpigmentation that a disturbance in the melanogenesis arises.
Various strategies have therefore been developed to reduce the pigmentation of the skin. One of the most often used skin and hair lighteners is hydroquinone or the hydroquinone glycoside of arbutin. However, these compounds have a cytotoxic effect on melanocytes and have an irritative effect on the skin. Another option is the inhibition of the synthesis of melanin by inhibiting the pacemaker enzyme tyrosinase. For this, the substances kojic acid and derivatives of kojic acid such as e.g. kojic acid dipalmitate kojic acid, azelaic acid, oxyresveratrol, linolenic acid, vitamin C and derivatives of ascorbic acid such as, for example, ascorbyl phosphate or ascorbyl palmitate, inter alia, are used.
However, these substances have a high sensitizing potential, cause contact allergies, exhibit inadequate chemical stability in cosmetic formulations, or have only an unsatisfactory effect on the skin.
Moreover, strategies are also known which prevent the transfer of the melanin from the melanocytes into the surrounding keratinocytes. Thus, protease inhibitors are described which inhibit the PAR2 receptor on the surface of the keratinocytes and as a result reduce the
FIELD OF THE INVENTION
The present invention relates generally to compositions of canola extracts containing high levels of phenolic acids and their methods of use to whiten skin.
BACKGROUND
In humans, melanin is the primary determinant of skin color. In the skin, specialized cells found in the basal layer of the dermis called melanocytes, produce melanin. Human possess similar concentrations of melanocytes in their skin, but present different concentrations of skin melanin based on their ethnicity.
Melanin plays an important biological role as a photoprotectant because it absorbs harmful UV radiation and transforms that energy into harmless heat. This property enables melanin to dissipate more than 99.9% of the absorbed UV radiation as heat.
Melanogenesis, or increased production of melanin in human skin, is stimulated by UVB-radiation to produce what is commonly known as a tan. Although a tan appearance is desired by some people in various cultures, some cultures desire a lighter skin appearance. Further, melanin pigment disorders are perceived as cosmetic flaws. Examples of these local hyperpigmentations would be: freckles, melasma, chloasma, post-inflammatory hyperpigmentation, liver spots and many more. It is common to all forms of hyperpigmentation that a disturbance in the melanogenesis arises.
Various strategies have therefore been developed to reduce the pigmentation of the skin. One of the most often used skin and hair lighteners is hydroquinone or the hydroquinone glycoside of arbutin. However, these compounds have a cytotoxic effect on melanocytes and have an irritative effect on the skin. Another option is the inhibition of the synthesis of melanin by inhibiting the pacemaker enzyme tyrosinase. For this, the substances kojic acid and derivatives of kojic acid such as e.g. kojic acid dipalmitate kojic acid, azelaic acid, oxyresveratrol, linolenic acid, vitamin C and derivatives of ascorbic acid such as, for example, ascorbyl phosphate or ascorbyl palmitate, inter alia, are used.
However, these substances have a high sensitizing potential, cause contact allergies, exhibit inadequate chemical stability in cosmetic formulations, or have only an unsatisfactory effect on the skin.
Moreover, strategies are also known which prevent the transfer of the melanin from the melanocytes into the surrounding keratinocytes. Thus, protease inhibitors are described which inhibit the PAR2 receptor on the surface of the keratinocytes and as a result reduce the
Claims (20)
1. A method for lightening skin comprising the step of identifying skin where lightening or whitening is desired and topically applying to the skin a composition comprising: (a) a skin lightening agent comprising a canola extract and (b) a cosmetically acceptable carrier.
2. The method of claim 1, wherein the canola extract comprises protocatechuic acid, vanilic acid, caffeic acid, syringic acid, P-coumaric acid, and sinapic acid.
3. The method of claim 1, wherein the canola extract comprises protocatechuic acid.
4. The method of claim 1, wherein the canola extract comprises vanilic acid.
5. The method of claim 1, wherein the canola extract comprises caffeic acid.
6. The method of claim 1, wherein the canola extract comprises syringic acid.
7. The method of claim 1, wherein the canola extract comprises P-coumaric acid.
8. The method of claim 1, wherein the canola extract comprises sinapic acid.
9. The method of claim 1, wherein the canola extract is selected from the group consisting of a total phenolic, a phenolic acid, a carotenoid, a tocopherol/sterol, a glucosinolate and combinations thereof.
10. The method of claim 9, wherein the canola extract comprises a glucosinolate selected from the group consisting of progoitrin, sinigrin, glucoraphanin, napoleferin, glucoalyssin, gluconapin, 4-hydroxybrassicin, glucobrassicanapin, glucobrassicin, gluconasturtin, 4-methoxy-glucobrassicin, neoglucobrassicin and combinations thereof.
11. A method for treating hyperpigmentation comprising the step of identifying skin containing areas of hyperpigmentation and topically applying to the skin a composition comprising: (a) a canola extract and (b) a cosmetically acceptable carrier.
12. The method of claim 11, wherein the canola extract comprises protocatechuic acid, vanilic acid, caffeic acid, syringic acid, P-coumaric acid, and sinapic acid.
13. The method of claim 11, wherein the canola extract comprises protocatechuic acid.
14. The method of claim 11, wherein the canola extract comprises vanilic acid.
15. The method of claim 11, wherein the canola extract comprises caffeic acid
16. The method of claim 11, wherein the canola extract comprises syringic acia.
17. The method of claim 11, wherein the canola extract comprises P-coumaric acid.
18. The method of claim 11, wherein the canola extract comprises sinapic acid.
19. The method of claim 11, wherein the canola extract is selected from the group consisting of a total phenolic, a phenolic acid, a carotenoid, a tocopherol/sterol, a glucosinolate and combinations thereof.
20. The method of claim 19, wherein the canola extract comprises a glucosinolate selected from the group consisting of progoitrin, sinigrin, glucoraphanin, napoleferin, glucoalyssin, gluconapin, 4-hydroxybrassicin, glucobrassicanapin, glucobrassicin, gluconasturtin, 4-methoxy-glucobrassicin, neoglucobrassicin and combinations thereof.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA3151148A CA3151148A1 (en) | 2013-01-31 | 2014-01-09 | Methods of skin whitening by use of canola extracts |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/755,143 | 2013-01-31 | ||
US13/755,143 US10172772B2 (en) | 2013-01-31 | 2013-01-31 | Methods of skin whitening by use of canola extracts |
PCT/IB2014/000019 WO2014118610A1 (en) | 2013-01-31 | 2014-01-09 | Methods of skin whitenening by use of canola extracts |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3151148A Division CA3151148A1 (en) | 2013-01-31 | 2014-01-09 | Methods of skin whitening by use of canola extracts |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2899814A1 true CA2899814A1 (en) | 2014-08-07 |
CA2899814C CA2899814C (en) | 2022-05-17 |
Family
ID=51223599
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3151148A Pending CA3151148A1 (en) | 2013-01-31 | 2014-01-09 | Methods of skin whitening by use of canola extracts |
CA2899814A Active CA2899814C (en) | 2013-01-31 | 2014-01-09 | Methods of skin whitening by use of canola extracts |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3151148A Pending CA3151148A1 (en) | 2013-01-31 | 2014-01-09 | Methods of skin whitening by use of canola extracts |
Country Status (8)
Country | Link |
---|---|
US (4) | US10172772B2 (en) |
EP (2) | EP2950779B1 (en) |
JP (3) | JP6815730B2 (en) |
KR (4) | KR102481374B1 (en) |
AU (2) | AU2014210919B2 (en) |
CA (2) | CA3151148A1 (en) |
ES (1) | ES2959418T3 (en) |
WO (1) | WO2014118610A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070098824A1 (en) | 2005-10-27 | 2007-05-03 | Kgk Synergize Inc. | Canola extracts containing high levels of phenolic acids |
US10172772B2 (en) | 2013-01-31 | 2019-01-08 | KGK Science, Inc. | Methods of skin whitening by use of canola extracts |
JP6902392B2 (en) * | 2016-06-22 | 2021-07-14 | オリザ油化株式会社 | Carbonylation inhibitor |
KR102662255B1 (en) * | 2016-09-06 | 2024-05-02 | 주식회사 엘지생활건강 | Composition for skin improvement containing sinigrin |
CN106619168A (en) * | 2016-11-25 | 2017-05-10 | 徐州得铸生物科技有限公司 | Skin-whitening active component containing natural compounds |
JP6861134B2 (en) * | 2017-09-15 | 2021-04-21 | ヤクルトヘルスフーズ株式会社 | Hyaluronic acid production promoter and hyaluronic acid production promoter food |
CN111217874B (en) * | 2018-11-23 | 2023-08-22 | 复旦大学 | Method for extracting and separating novel glucose brassin from isatis root |
CN109806199B (en) * | 2019-03-19 | 2021-09-03 | 成都大学 | Whitening skin care composition and preparation method thereof |
KR102272490B1 (en) * | 2019-11-04 | 2021-07-05 | 주식회사 한국인삼공사 | Cosmetic Composition for Skin Whitening Comprising Sinapaldehyde or Derative thereof |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5766575A (en) * | 1996-06-14 | 1998-06-16 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Method and composition for skin lightening |
GB9903216D0 (en) * | 1999-02-13 | 1999-04-07 | Zylepsis Ltd | Preservative compounds,compositions and methods of making and using the same |
WO2002022146A2 (en) | 2000-09-15 | 2002-03-21 | Kgk Synergize | Components of canola for treating hyperlipidemia |
AU2001290165A1 (en) | 2000-09-15 | 2002-03-26 | Kgk Synergize | Components of canola for the treatment of cancer |
FR2869228B1 (en) * | 2004-04-21 | 2008-09-05 | Vincience Sa | USE OF CRUCIFEROUS PROTEIN HYDROLYSAT AS DEPIGMENTING AGENT IN OR FOR A COSMETIC AND / OR PHARMACEUTICAL COMPOSITION |
JP4831454B2 (en) * | 2004-07-02 | 2011-12-07 | 独立行政法人産業技術総合研究所 | Topical skin preparation |
JP2008526963A (en) * | 2005-01-14 | 2008-07-24 | リポ ケミカルズ インコーポレイテッド | Compositions and methods for treating overpigmented skin |
US20070098824A1 (en) | 2005-10-27 | 2007-05-03 | Kgk Synergize Inc. | Canola extracts containing high levels of phenolic acids |
EP1967175A1 (en) * | 2007-03-06 | 2008-09-10 | Cognis IP Management GmbH | Use of derivatives of sinapinic acid and compositions comprising such derivatives |
JP5559463B2 (en) * | 2008-03-12 | 2014-07-23 | 株式会社コーセー | Whitening agent containing shikimic acid as active ingredient |
US20090317341A1 (en) * | 2008-06-18 | 2009-12-24 | Conopco, Inc., D/B/A Unilever | Compositions for Lightening Skin Color |
US10172772B2 (en) * | 2013-01-31 | 2019-01-08 | KGK Science, Inc. | Methods of skin whitening by use of canola extracts |
-
2013
- 2013-01-31 US US13/755,143 patent/US10172772B2/en active Active
-
2014
- 2014-01-09 ES ES14746867T patent/ES2959418T3/en active Active
- 2014-01-09 EP EP14746867.2A patent/EP2950779B1/en active Active
- 2014-01-09 KR KR1020217030296A patent/KR102481374B1/en active IP Right Grant
- 2014-01-09 WO PCT/IB2014/000019 patent/WO2014118610A1/en active Application Filing
- 2014-01-09 CA CA3151148A patent/CA3151148A1/en active Pending
- 2014-01-09 KR KR1020227044998A patent/KR102670526B1/en active IP Right Grant
- 2014-01-09 EP EP23165601.8A patent/EP4223279A1/en active Pending
- 2014-01-09 KR KR1020157023569A patent/KR102306035B1/en active IP Right Grant
- 2014-01-09 KR KR1020247017520A patent/KR20240091015A/en unknown
- 2014-01-09 AU AU2014210919A patent/AU2014210919B2/en active Active
- 2014-01-09 CA CA2899814A patent/CA2899814C/en active Active
- 2014-01-09 JP JP2015555814A patent/JP6815730B2/en active Active
-
2019
- 2019-01-08 US US16/242,266 patent/US20190374453A1/en not_active Abandoned
- 2019-02-07 AU AU2019200853A patent/AU2019200853B2/en active Active
- 2019-11-25 JP JP2019212362A patent/JP2020059727A/en active Pending
-
2020
- 2020-04-07 US US16/842,686 patent/US11896696B2/en active Active
-
2023
- 2023-01-31 JP JP2023012604A patent/JP2023065363A/en active Pending
-
2024
- 2024-02-07 US US18/435,132 patent/US20240173229A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4223279A1 (en) | 2023-08-09 |
EP2950779C0 (en) | 2023-08-16 |
KR102481374B1 (en) | 2022-12-23 |
KR102306035B1 (en) | 2021-09-27 |
KR102670526B1 (en) | 2024-05-28 |
EP2950779B1 (en) | 2023-08-16 |
EP2950779A1 (en) | 2015-12-09 |
AU2019200853B2 (en) | 2020-02-06 |
US20240173229A1 (en) | 2024-05-30 |
JP6815730B2 (en) | 2021-01-20 |
US20190374453A1 (en) | 2019-12-12 |
US10172772B2 (en) | 2019-01-08 |
US20140213652A1 (en) | 2014-07-31 |
KR20230004950A (en) | 2023-01-06 |
KR20210119566A (en) | 2021-10-05 |
JP2016511236A (en) | 2016-04-14 |
KR20150114534A (en) | 2015-10-12 |
AU2019200853A1 (en) | 2019-02-28 |
ES2959418T3 (en) | 2024-02-26 |
JP2023065363A (en) | 2023-05-12 |
EP2950779A4 (en) | 2016-08-03 |
KR20240091015A (en) | 2024-06-21 |
CA3151148A1 (en) | 2014-08-07 |
AU2014210919B2 (en) | 2018-11-08 |
AU2014210919A1 (en) | 2015-08-20 |
JP2020059727A (en) | 2020-04-16 |
US20200397678A1 (en) | 2020-12-24 |
WO2014118610A1 (en) | 2014-08-07 |
CA2899814C (en) | 2022-05-17 |
US11896696B2 (en) | 2024-02-13 |
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EEER | Examination request |
Effective date: 20190104 |