CA2891830A1 - Genetic markers for suicide risk and related methods - Google Patents

Genetic markers for suicide risk and related methods Download PDF

Info

Publication number
CA2891830A1
CA2891830A1 CA2891830A CA2891830A CA2891830A1 CA 2891830 A1 CA2891830 A1 CA 2891830A1 CA 2891830 A CA2891830 A CA 2891830A CA 2891830 A CA2891830 A CA 2891830A CA 2891830 A1 CA2891830 A1 CA 2891830A1
Authority
CA
Canada
Prior art keywords
subject
risk
genotype
snps
ssb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2891830A
Other languages
English (en)
French (fr)
Inventor
Clement C. Zai
James L. Kennedy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre for Addiction and Mental Health
Original Assignee
Centre for Addiction and Mental Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre for Addiction and Mental Health filed Critical Centre for Addiction and Mental Health
Priority to CA2891830A priority Critical patent/CA2891830A1/en
Priority to PCT/CA2015/051206 priority patent/WO2016183659A1/en
Priority to JP2017559528A priority patent/JP2018521629A/ja
Priority to HK18111730.2A priority patent/HK1252429A1/zh
Priority to US15/574,037 priority patent/US11104952B2/en
Priority to EP15892076.9A priority patent/EP3294902A4/en
Priority to CA2985841A priority patent/CA2985841A1/en
Publication of CA2891830A1 publication Critical patent/CA2891830A1/en
Priority to IL255653A priority patent/IL255653A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/40Population genetics; Linkage disequilibrium
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B99/00Subject matter not provided for in other groups of this subclass
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/30Psychoses; Psychiatry
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00ICT specially adapted for sequence analysis involving nucleotides or amino acids

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Ecology (AREA)
  • Physiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2891830A 2015-05-15 2015-05-15 Genetic markers for suicide risk and related methods Abandoned CA2891830A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2891830A CA2891830A1 (en) 2015-05-15 2015-05-15 Genetic markers for suicide risk and related methods
PCT/CA2015/051206 WO2016183659A1 (en) 2015-05-15 2015-11-19 Genetic markers for suicide risk and related methods
JP2017559528A JP2018521629A (ja) 2015-05-15 2015-11-19 自殺リスクに関する遺伝マーカーおよび関連する方法
HK18111730.2A HK1252429A1 (zh) 2015-05-15 2015-11-19 自杀风险的遗传标记及相关方法
US15/574,037 US11104952B2 (en) 2015-05-15 2015-11-19 Genetic markers for suicide risk and related methods
EP15892076.9A EP3294902A4 (en) 2015-05-15 2015-11-19 Genetic markers for suicide risk and related methods
CA2985841A CA2985841A1 (en) 2015-05-15 2015-11-19 Genetic markers for suicide risk and related methods
IL255653A IL255653A (en) 2015-05-15 2017-11-14 Genetic markers for suicide risk and related methods

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2891830A CA2891830A1 (en) 2015-05-15 2015-05-15 Genetic markers for suicide risk and related methods

Publications (1)

Publication Number Publication Date
CA2891830A1 true CA2891830A1 (en) 2016-11-15

Family

ID=57298829

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2891830A Abandoned CA2891830A1 (en) 2015-05-15 2015-05-15 Genetic markers for suicide risk and related methods
CA2985841A Pending CA2985841A1 (en) 2015-05-15 2015-11-19 Genetic markers for suicide risk and related methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2985841A Pending CA2985841A1 (en) 2015-05-15 2015-11-19 Genetic markers for suicide risk and related methods

Country Status (7)

Country Link
US (1) US11104952B2 (https=)
EP (1) EP3294902A4 (https=)
JP (1) JP2018521629A (https=)
CA (2) CA2891830A1 (https=)
HK (1) HK1252429A1 (https=)
IL (1) IL255653A (https=)
WO (1) WO2016183659A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10395759B2 (en) 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
CA3014292A1 (en) 2016-02-12 2017-08-17 Regeneron Pharmaceuticals, Inc. Methods and systems for detection of abnormal karyotypes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716810B1 (en) * 1998-12-09 2004-04-06 Eleanor Roosevelt Institute Composition and method for regulation of body weight and associated conditions
USH2191H1 (en) 2000-10-24 2007-06-05 Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
WO2004074513A1 (en) * 2003-02-21 2004-09-02 Novartis Ag Methods for the prediction of suicidality during treatment
US7361468B2 (en) 2004-07-02 2008-04-22 Affymetrix, Inc. Methods for genotyping polymorphisms in humans
WO2006102476A2 (en) * 2005-03-21 2006-09-28 Vicus Therapeutics Spe 1, Llc Compositions and methods for ameliorating cachexia
US7906283B2 (en) * 2006-10-27 2011-03-15 The United States Of America As Represented By The Department Of Health And Human Services Methods to identify patients at risk of developing adverse events during treatment with antidepressant medication
US20120094855A1 (en) * 2008-09-18 2012-04-19 Max Planck Society Means and methods for diagnosing predisposition for treatment emergent suicidal ideation (tesi)
EP2166112B1 (en) 2008-09-18 2013-06-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Means and methods for diagnosing predisposition for treatment emergent suicidal ideation
KR101249635B1 (ko) 2010-10-13 2013-04-01 서울대학교산학협력단 양극성 장애 진단용 egr2 유전자 snp, 그를 포함하는 마이크로어레이 및 키트
CN106062213A (zh) 2013-12-23 2016-10-26 戒毒及精神卫生中心 与自杀风险关联的遗传标志物及其使用方法

Also Published As

Publication number Publication date
IL255653A (en) 2018-01-31
EP3294902A1 (en) 2018-03-21
JP2018521629A (ja) 2018-08-09
CA2985841A1 (en) 2016-11-24
WO2016183659A1 (en) 2016-11-24
US11104952B2 (en) 2021-08-31
HK1252429A1 (zh) 2019-05-24
US20180355431A1 (en) 2018-12-13
EP3294902A4 (en) 2018-09-26

Similar Documents

Publication Publication Date Title
Lee et al. Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment
Pelleri et al. Systematic reanalysis of partial trisomy 21 cases with or without Down syndrome suggests a small region on 21q22. 13 as critical to the phenotype
Meng et al. A genome-wide association study provides evidence of sex-specific involvement of Chr1p35. 1 (ZSCAN20-TLR12P) and Chr8p23. 1 (HMGB1P46) with diabetic neuropathic pain
Córdova-Palomera et al. Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins
Sullivan et al. NCAM1 and neurocognition in schizophrenia
Zai et al. A genome-wide association study of suicide severity scores in bipolar disorder
Pathak et al. Genome-wide methylation of mild cognitive impairment in mexican americans highlights genes involved in synaptic transport, alzheimer’s disease-precursor phenotypes, and metabolic morbidities
Powis et al. Clinical diagnostic exome sequencing in dystonia: genetic testing challenges for complex conditions
Qian et al. The ABCC2 c.-24C> T polymorphism increases the risk of resistance to antiepileptic drugs: a meta-analysis
Moreau et al. Brain functional connectivity mirrors genetic pleiotropy in psychiatric conditions
Levey et al. GWAS of depression phenotypes in the million veteran program and meta-analysis in more than 1.2 million participants yields 178 independent risk loci
Huang et al. Association between biological ageing and periodontitis: Evidence from a cross‐sectional survey and multi‐omics Mendelian randomization analysis
Dimova et al. Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery
Khan et al. Combining transdiagnostic and disorder-level GWAS enhances precision of psychiatric genetic risk profiles in a multi-ancestry sample
US11104952B2 (en) Genetic markers for suicide risk and related methods
Roecklein et al. Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura
Kember et al. Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brain
Seidlitz et al. The molecular genetic landscape of human brain size variation
CN101294220A (zh) 判断重性抑郁症发病易感性的方法
Zaks et al. Clinical and Cognitive Phenotyping of Copy Number Variants Associated with Neurodevelopmental Disorders From a Multi-Ancestry Biobank
Kazem et al. Gene dosage architecture across complex traits
JP2020500037A (ja) オピオイド中毒を治療するための方法
Osinsky et al. Genetic influences on implicit measures of personality
Zhou et al. Genome-wide meta-analysis of alcohol use disorder in east asians
Cho et al. Both vascular risk factors and common genetic variants influence penetrance of variants causing monogenic stroke

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20211123