CA2889519A1 - Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion - Google Patents

Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion Download PDF

Info

Publication number
CA2889519A1
CA2889519A1 CA2889519A CA2889519A CA2889519A1 CA 2889519 A1 CA2889519 A1 CA 2889519A1 CA 2889519 A CA2889519 A CA 2889519A CA 2889519 A CA2889519 A CA 2889519A CA 2889519 A1 CA2889519 A1 CA 2889519A1
Authority
CA
Canada
Prior art keywords
insulin
bone tissue
bone
fusion
mimetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2889519A
Other languages
English (en)
French (fr)
Inventor
Sheldon Suton Lin
John KOERNER
Michael J. Vives
Joseph Benevenia
Eric Breitbart
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Original Assignee
Rutgers State University of New Jersey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rutgers State University of New Jersey filed Critical Rutgers State University of New Jersey
Publication of CA2889519A1 publication Critical patent/CA2889519A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455—Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00359—Bone or bony tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/38—Materials or treatment for tissue regeneration for reconstruction of the spine, vertebrae or intervertebral discs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)
CA2889519A 2012-10-25 2013-10-25 Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion Abandoned CA2889519A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718646P 2012-10-25 2012-10-25
US61/718,646 2012-10-25
PCT/US2013/066895 WO2014066808A1 (en) 2012-10-25 2013-10-25 Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion

Publications (1)

Publication Number Publication Date
CA2889519A1 true CA2889519A1 (en) 2014-05-01

Family

ID=50545335

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2889519A Abandoned CA2889519A1 (en) 2012-10-25 2013-10-25 Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion

Country Status (6)

Country Link
US (1) US20150004249A1 (OSRAM)
EP (1) EP2911614A4 (OSRAM)
JP (1) JP2015534850A (OSRAM)
AU (1) AU2013334111A1 (OSRAM)
CA (1) CA2889519A1 (OSRAM)
WO (1) WO2014066808A1 (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12419978B2 (en) 2016-02-09 2025-09-23 Rutgers, The State University Of New Jersey Antimicrobial composition for inhibiting microbial organisms in allograft and the method thereof
US12178205B2 (en) 2016-02-09 2024-12-31 Rutgers, The State University Of New Jersey Systems and methods for storing and preserving implantable devices
EP3988092B1 (en) * 2019-06-24 2026-01-28 Shenzhen Fangshengtai Medical Technology Co., Ltd. Oxovanadium complexes for use in the treatment of pain

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4834757A (en) * 1987-01-22 1989-05-30 Brantigan John W Prosthetic implant
US5614206A (en) * 1995-03-07 1997-03-25 Wright Medical Technology, Inc. Controlled dissolution pellet containing calcium sulfate
ES2384405T3 (es) * 2000-10-24 2012-07-04 Warsaw Orthopedic, Inc. Dispositivos para fusionar vértebras
US7291179B2 (en) * 2002-06-24 2007-11-06 Wright Medical Technology, Inc. Bone graft substitute composition
CN100344334C (zh) * 2002-12-31 2007-10-24 华中科技大学同济医学院附属协和医院 骨组织填充材料
US20040230309A1 (en) * 2003-02-14 2004-11-18 Depuy Spine, Inc. In-situ formed intervertebral fusion device and method
US9199005B2 (en) * 2003-10-01 2015-12-01 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
US7419680B2 (en) * 2003-10-01 2008-09-02 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
US7189409B2 (en) * 2004-03-09 2007-03-13 Inion Ltd. Bone grafting material, method and implant
EP1991284A4 (en) * 2006-02-01 2012-07-04 Jake Barralet BIOIMPLANTS FOR USE IN TISSUE GROWTH
EP2257163A4 (en) * 2008-03-10 2012-01-18 Marfly 2 Lp BONE PASTE COMPOSITION
BRPI1015155B1 (pt) * 2009-04-01 2022-07-19 Difusion Technologies, Inc. Substituto de enxerto ósseo, implante e dispositivo intracorpóreo, bem como métodos para modulação da mineralização e formação óssea, para promover a fusão espinhal e para sobreregular seletivamente a expressão de proteínas morfogenéticas ósseas
EP2523672B1 (en) * 2010-01-15 2016-07-13 Rutgers, the State University of New Jersey Use of vanadium compounds to accelerate bone healing
CN103781358A (zh) * 2010-12-10 2014-05-07 新泽西医科和牙科大学 涂布有胰岛素模拟剂复合材料的可植入装置及其方法
EP2785358B1 (en) * 2011-11-29 2022-06-01 Rutgers, the State University of New Jersey Insulin-mimetics as therapeutic adjuncts for bone regeneration

Also Published As

Publication number Publication date
EP2911614A1 (en) 2015-09-02
EP2911614A4 (en) 2016-04-13
JP2015534850A (ja) 2015-12-07
WO2014066808A1 (en) 2014-05-01
US20150004249A1 (en) 2015-01-01
AU2013334111A1 (en) 2015-05-28

Similar Documents

Publication Publication Date Title
US7763582B2 (en) Localized insulin delivery for bone healing
CA2787208C (en) Use of vanadium compounds to accelerate bone healing
EP0608313B1 (en) Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
JP6214548B2 (ja) 骨再生のための治療補助薬としてのインスリン−疑似剤
HRP20040486A2 (en) Controlled release polymeric compositions of bone growth promoting compounds
US9999636B2 (en) Insulin-mimetics as therapeutic adjuncts for bone regeneration
US20200237959A1 (en) Autologous Bone Graft Substitute
McClendon et al. A supramolecular polymer-collagen microparticle slurry for bone regeneration with minimal growth factor
US20150004249A1 (en) Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion
US20170035803A1 (en) Insulin-mimetic local therapeutic adjuncts for enhancing spinal fusion
US9931348B2 (en) Vanadium compounds as therapeutic adjuncts for cartilage injury and repair
AU2011205741B2 (en) Use of vanadium compounds to accelerate bone healing
US20180318344A1 (en) Zinc or manganese compounds as therapeutic adjuncts for cartilage regeneration and repair
HK1178799B (en) Use of vanadium compounds to accelerate bone healing

Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20181025