CA2888759C - Autophagy-inducing peptide analogs - Google Patents

Autophagy-inducing peptide analogs Download PDF

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Publication number
CA2888759C
CA2888759C CA2888759A CA2888759A CA2888759C CA 2888759 C CA2888759 C CA 2888759C CA 2888759 A CA2888759 A CA 2888759A CA 2888759 A CA2888759 A CA 2888759A CA 2888759 C CA2888759 C CA 2888759C
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CA
Canada
Prior art keywords
compound
peptide
beclin
autophagy
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2888759A
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English (en)
French (fr)
Other versions
CA2888759A1 (en
Inventor
Beth C. Levine
Sanae SHOJI-KAWATA
Nick V. Grishin
Lisa N. Kinch
Olivier Lichtarge
Angela D. Wilkins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
The University of Texas System
Original Assignee
Baylor College of Medicine
The University of Texas System
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Publication date
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Publication of CA2888759A1 publication Critical patent/CA2888759A1/en
Application granted granted Critical
Publication of CA2888759C publication Critical patent/CA2888759C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA2888759A 2013-03-18 2014-02-26 Autophagy-inducing peptide analogs Active CA2888759C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361803095P 2013-03-18 2013-03-18
US61/803,095 2013-03-18
PCT/US2014/018467 WO2014149440A1 (en) 2013-03-18 2014-02-26 Autophagy-inducing peptide analogs

Publications (2)

Publication Number Publication Date
CA2888759A1 CA2888759A1 (en) 2014-09-25
CA2888759C true CA2888759C (en) 2016-11-29

Family

ID=51267254

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2888759A Active CA2888759C (en) 2013-03-18 2014-02-26 Autophagy-inducing peptide analogs

Country Status (6)

Country Link
US (2) US8802633B1 (enExample)
EP (1) EP2976353B1 (enExample)
JP (1) JP2016516734A (enExample)
AU (1) AU2014238163B2 (enExample)
CA (1) CA2888759C (enExample)
WO (1) WO2014149440A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017055370A1 (en) 2015-09-28 2017-04-06 Fondazione Telethon Treatment of bone growth disorders
US10993983B2 (en) 2016-03-18 2021-05-04 Trustees Of Tufts College Cyclic peptide epitopes and small-molecule mimics for inducing autophagy
US20190183908A1 (en) 2016-05-13 2019-06-20 Case Western Reserve University Autophagy activators for treating or preventing skin injury
US10618939B2 (en) 2016-06-29 2020-04-14 The Hong Kong Polytechnic University Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation
US20180002381A1 (en) * 2016-06-29 2018-01-04 The Hong Kong Polytechnic University Hydrocarbon-stapled polypeptides for enhancement of endosome-lysosomal degradation
JP7395517B2 (ja) * 2018-07-11 2023-12-11 イミュニティ ファルマ リミテッド ペプチド化合物およびその治療的用途
US20230321188A1 (en) * 2020-08-19 2023-10-12 Translational Health Science And Technology Institute Autophagy inducing peptides
WO2022111829A1 (en) 2020-11-30 2022-06-02 Symrise Ag Essential oils of citrus fruits for use as medicament for induced, increased and/or accelerated autophagy in human keratinocytes
CN117223676B (zh) * 2023-09-25 2024-08-20 武汉大学 面中部发育畸形动物选育方法、辅助选育试剂和预防药物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2881429B1 (fr) * 2005-02-01 2007-04-06 Servier Lab Motif de la proteine beclin interagissant avec les membres anti-apoptotiques de la famille de proteines bcl-2 et utilisations
WO2011088421A2 (en) * 2010-01-15 2011-07-21 California Institute Of Technology Discovery and applications of the proteolytic function of n-terminal acetylation of cellular proteins
US20130202646A1 (en) * 2010-02-25 2013-08-08 San Diego State University (Sdsu) Foundation Compositions and methods for modulating autophagy
EP2812347B1 (en) * 2012-02-11 2016-08-24 Board Of Regents, The University Of Texas System Autophagy-inducing peptide

Also Published As

Publication number Publication date
US8802633B1 (en) 2014-08-12
AU2014238163B2 (en) 2015-11-26
CA2888759A1 (en) 2014-09-25
EP2976353A1 (en) 2016-01-27
JP2016516734A (ja) 2016-06-09
US20150359840A1 (en) 2015-12-17
WO2014149440A1 (en) 2014-09-25
AU2014238163A1 (en) 2015-09-24
EP2976353B1 (en) 2018-12-26
EP2976353A4 (en) 2016-02-10
US10300106B2 (en) 2019-05-28

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