CA2881729C - Drug delivery composition comprising proteins and biodegradable polyesteramides - Google Patents

Drug delivery composition comprising proteins and biodegradable polyesteramides Download PDF

Info

Publication number
CA2881729C
CA2881729C CA2881729A CA2881729A CA2881729C CA 2881729 C CA2881729 C CA 2881729C CA 2881729 A CA2881729 A CA 2881729A CA 2881729 A CA2881729 A CA 2881729A CA 2881729 C CA2881729 C CA 2881729C
Authority
CA
Canada
Prior art keywords
composition according
release
protein
drug delivery
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2881729A
Other languages
English (en)
French (fr)
Other versions
CA2881729A1 (en
Inventor
Jens Christoph Thies
George Mihov
Guy Draaisma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CA2881729A1 publication Critical patent/CA2881729A1/en
Application granted granted Critical
Publication of CA2881729C publication Critical patent/CA2881729C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/44—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/12—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01007—Peroxidase (1.11.1.7), i.e. horseradish-peroxidase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2881729A 2012-10-02 2013-10-02 Drug delivery composition comprising proteins and biodegradable polyesteramides Active CA2881729C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP12186915.0 2012-10-02
EP12186915 2012-10-02
EP13173634.0 2013-06-25
EP13173634 2013-06-25
PCT/EP2013/070543 WO2014053542A1 (en) 2012-10-02 2013-10-02 Drug delivery composition comprising proteins and biodegradable polyesteramides

Publications (2)

Publication Number Publication Date
CA2881729A1 CA2881729A1 (en) 2014-04-10
CA2881729C true CA2881729C (en) 2021-05-04

Family

ID=49301494

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2881729A Active CA2881729C (en) 2012-10-02 2013-10-02 Drug delivery composition comprising proteins and biodegradable polyesteramides

Country Status (7)

Country Link
US (1) US9789189B2 (https=)
EP (1) EP2903592B1 (https=)
JP (1) JP6330815B2 (https=)
CN (1) CN104717962B (https=)
CA (1) CA2881729C (https=)
IN (1) IN2015DN01153A (https=)
WO (1) WO2014053542A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
US9963549B2 (en) 2011-06-23 2018-05-08 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CA2881729C (en) 2012-10-02 2021-05-04 Dsm Ip Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
US20150328374A1 (en) * 2012-12-20 2015-11-19 Dsm Ip Assets B.V. Coating comprising polyesteramide copolymers for drug delivery
EP3233067B1 (en) * 2014-12-18 2019-11-06 DSM IP Assets B.V. Drug delivery system for delivery of acid sensitive drugs
US10500318B1 (en) 2018-07-03 2019-12-10 Temple Therapeutics BV Dosing regimens for treating hypoxia-associated tissue damage
MX2021010599A (es) * 2019-03-05 2021-12-10 Aerie Pharmaceuticals Inc Composiciones farmaceuticas para el tratamiento de enfermedades o trastornos oculares.
US12577398B2 (en) 2019-11-12 2026-03-17 Dsm Ip Assets B.V. Polyesteramide copolymers possessing high glass transition temperatures
WO2022234489A1 (en) 2021-05-07 2022-11-10 Temple Therapeutics BV Methods of treating fibrosis and hypoxia-associated damage to peripheral nerves
WO2025163204A1 (en) 2024-02-01 2025-08-07 Temple Therapeutics BV Glutamine source for use in methods and compositions for reducing or preventing synovial joint adhesions or fibrosis

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4550730A (en) 1981-12-07 1985-11-05 Ethicon, Inc. Flexible monofilament surgical sutures comprising poly(polymethylene terephthalate, isophthalate or cyclohexane-1,4-dicarboxylate-co-dimerate)
EP0926184A1 (en) 1997-12-25 1999-06-30 Mitsui Chemicals, Inc. Process for production of polyamino acid derivative
WO2000000222A1 (en) 1998-06-30 2000-01-06 Amgen Inc. Thermosensitive biodegradable hydrogels for sustained delivery of biologically active agents
US6503538B1 (en) 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US7304122B2 (en) 2001-08-30 2007-12-04 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
EP1603485A4 (en) 2003-02-26 2011-03-30 Medivas Llc BIOACTIVE STENTS AND METHOD OF USE THEREOF
JP2005139139A (ja) 2003-11-07 2005-06-02 Idemitsu Technofine Co Ltd 化粧料組成物
EP1765426A4 (en) 2004-05-12 2011-07-27 Medivas Llc WOUND HEALING POLYMER COMPOSITIONS AND METHOD FOR THEIR USE
US20050271700A1 (en) 2004-06-03 2005-12-08 Desnoyer Jessica R Poly(ester amide) coating composition for implantable devices
CA2573668A1 (en) 2004-07-12 2006-02-16 Allergan, Inc. Ophthalmic compositions and methods for treating ophthalmic conditions
US7390497B2 (en) 2004-10-29 2008-06-24 Advanced Cardiovascular Systems, Inc. Poly(ester amide) filler blends for modulation of coating properties
US20060159918A1 (en) 2004-12-22 2006-07-20 Fiber Innovation Technology, Inc. Biodegradable fibers exhibiting storage-stable tenacity
CN100551950C (zh) 2005-03-21 2009-10-21 中国科学院成都有机化学有限公司 一种可降解聚酯酰胺共聚物的制备方法
CA2623239C (en) 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
JP5192384B2 (ja) 2005-09-22 2013-05-08 メディバス エルエルシー ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法
WO2008048298A2 (en) 2005-11-21 2008-04-24 Medivas, Llc Polymer particles for delivery of macromolecules and methods of use
US8974815B2 (en) 2005-12-16 2015-03-10 Cornell University Fibrous membrane for biomedical application based on poly(ester-amide)s
TWI376239B (en) 2006-02-01 2012-11-11 Andrew Xian Chen Vitamin e succinate stabilized pharmaceutical compositions, methods for the preparation and the use thereof
CA2649672C (en) 2006-05-02 2015-07-07 Medivas, Llc Delivery of ophthalmologic agents to the exterior or interior of the eye
US20070282011A1 (en) 2006-05-09 2007-12-06 Medivas, Llc Biodegradable water soluble polymers
US8936780B2 (en) 2006-08-30 2015-01-20 Advanced Cardiovascular Systems, Inc. Stimuli responsive polyester amide particles
TWI481968B (zh) 2006-09-08 2015-04-21 尼康股份有限公司 A mask, an exposure device, and an element manufacturing method
US7649022B2 (en) 2007-03-30 2010-01-19 Medivas, Llc Bioabsorbable elastomeric polymer networks, cross-linkers and methods of use
US9737638B2 (en) 2007-06-20 2017-08-22 Abbott Cardiovascular Systems, Inc. Polyester amide copolymers having free carboxylic acid pendant groups
EP2170419A1 (en) 2007-07-18 2010-04-07 Board Of Trustees Of The University Of Illinois Temporal release of growth factors from 3d micro rod scaffolds for tissue regeneration
CA2774036C (en) 2009-10-16 2018-04-03 Dsm Ip Assets B.V. Coatings comprising bis-(alpha-amino-diol-diester) containing polyesteramide
CA2798084A1 (en) 2010-05-17 2011-11-24 Aerie Pharmaceuticals, Inc. Drug delivery devices for delivery of ocular therapeutic agents
WO2012150255A1 (en) 2011-05-02 2012-11-08 Dsm Ip Assets B.V. Bis-(alpha-amino-diol-diester) containing polyesteramide for ophtamology
JP6135870B2 (ja) 2011-05-02 2017-05-31 ディーエスエム アイピー アセッツ ビー．ブイ． 生分解性ポリマーを含む繊維
US9963549B2 (en) 2011-06-23 2018-05-08 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
US20150038415A1 (en) 2011-12-16 2015-02-05 Dsm Ip Assets B.V. Process for the manufacturing of a drug delivery system based on a polymer comprising a dispersed bioactive agent
CA2881729C (en) 2012-10-02 2021-05-04 Dsm Ip Assets B.V. Drug delivery composition comprising proteins and biodegradable polyesteramides
CA2888840C (en) 2012-10-23 2021-06-22 Dsm Ip Assets B.V. Process for the manufacturing of a multilayer drug delivery construct
US10538864B2 (en) 2012-10-24 2020-01-21 Dsm Ip Assets, B.V. Fibers comprising polyesteramide copolymers for drug delivery
US20150328374A1 (en) 2012-12-20 2015-11-19 Dsm Ip Assets B.V. Coating comprising polyesteramide copolymers for drug delivery

Also Published As

Publication number Publication date
CA2881729A1 (en) 2014-04-10
IN2015DN01153A (https=) 2015-06-26
US20150216987A1 (en) 2015-08-06
JP6330815B2 (ja) 2018-05-30
US9789189B2 (en) 2017-10-17
EP2903592A1 (en) 2015-08-12
CN104717962A (zh) 2015-06-17
WO2014053542A1 (en) 2014-04-10
EP2903592B1 (en) 2019-01-23
CN104717962B (zh) 2017-07-21
JP2015534557A (ja) 2015-12-03

Similar Documents

Publication Publication Date Title
CA2881729C (en) Drug delivery composition comprising proteins and biodegradable polyesteramides
US9896544B2 (en) Biodegradable polyesteramide copolymers for drug delivery
Nguyen et al. Injectable biodegradable hydrogels
US7722896B2 (en) Polyarylates for drug delivery and tissue engineering
EP2790667B1 (en) Process for the manufacturing of a drug delivery system based on a polymer comprising a dispersed bioactive agent
US8865148B2 (en) Polyesteramide platform for site specific drug delivery
Hoang Thi et al. Self-assemblable polymer smart-blocks for temperature-induced injectable hydrogel in biomedical applications
EP2911647B1 (en) Process for the manufacturing of a multilayer drug delivery construct
JP4015994B2 (ja) 薬剤キャリヤーとしての陽電荷両親媒性ブロック共重合体および当該共重合体と陰電荷性薬剤との複合体
Ghadi et al. Synthetic biodegradable medical polymer: Polyanhydrides
Katsarava et al. Biodegradable Polymers Composed of Naturally Occurring α‐Amino Acids
Markland et al. Biodegradable polymers as drug carriers
US9873765B2 (en) Biodegradable polyesteramide copolymers for drug delivery
Censi et al. In‐Situ Gelling Thermosensitive Hydrogels for Protein Delivery Applications
Censi et al. Hydrogels for Protein Delivery

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180925

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 11TH ANNIV.) - STANDARD

Year of fee payment: 11

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240905

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20240905

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20240905

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 12TH ANNIV.) - STANDARD

Year of fee payment: 12

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250902

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250902