CA2875419A1 - Sensitive efficacy and specificity biomarkers for proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibition - Google Patents
Sensitive efficacy and specificity biomarkers for proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibition Download PDFInfo
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- CA2875419A1 CA2875419A1 CA2875419A CA2875419A CA2875419A1 CA 2875419 A1 CA2875419 A1 CA 2875419A1 CA 2875419 A CA2875419 A CA 2875419A CA 2875419 A CA2875419 A CA 2875419A CA 2875419 A1 CA2875419 A1 CA 2875419A1
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261651569P | 2012-05-25 | 2012-05-25 | |
| US61/651,569 | 2012-05-25 | ||
| EP12169517.5A EP2667197B1 (en) | 2012-05-25 | 2012-05-25 | Sensitive efficacy and specificity biomarkers for proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition |
| EP12169517.5 | 2012-05-25 | ||
| PCT/EP2013/060816 WO2013175016A1 (en) | 2012-05-25 | 2013-05-24 | Sensitive efficacy and specificity biomarkers for proprotein convertase subtilisin/kexin type 9 (pcsk9) inhibition |
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| CA2875419A1 true CA2875419A1 (en) | 2013-11-28 |
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| EP (1) | EP2667197B1 (cg-RX-API-DMAC7.html) |
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| ES (1) | ES2552371T3 (cg-RX-API-DMAC7.html) |
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| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| WO2014135696A1 (en) * | 2013-03-08 | 2014-09-12 | Zora Biosciences Oy | Non-high density lipoprotein derived cvd markers |
| WO2017097852A2 (en) * | 2015-12-07 | 2017-06-15 | Zora Biosciences Oy | Use of ceramides and lpls in diagnosing cvd |
| EP3515950A4 (en) | 2016-09-20 | 2020-10-28 | Wuxi Biologics Ireland Limited. | NEW ANTI-PCSK9 ANTIBODIES |
| CN114062581A (zh) * | 2017-12-14 | 2022-02-18 | 江苏豪思生物科技有限公司 | 一种用于评估冠状动脉疾病的试剂盒 |
| WO2019119049A1 (en) * | 2017-12-20 | 2019-06-27 | Baker Heart and Diabetes Institute | Method of predicting drug therapeutic responder status and methods of treatment |
| CN109504737A (zh) * | 2018-11-23 | 2019-03-22 | 黄河科技学院 | 一种体外筛选pcsk9抑制剂的方法 |
| WO2022089486A1 (zh) * | 2020-10-28 | 2022-05-05 | 江苏柯菲平医药股份有限公司 | 抑制PCSK9基因表达的siRNA及其修饰物与应用 |
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| WO2007127192A2 (en) * | 2006-04-24 | 2007-11-08 | Duke University | Lipidomic approaches to determining drug response phenotypes in cardiovascular disease |
| CA2658183A1 (en) * | 2006-07-17 | 2008-01-24 | Sirna Therapeutics Inc. | Rna interference mediated inhibition of proprotein convertase subtilisin kexin 9 (pcsk9) gene expression using short interfering nucleic acid (sina) |
| US20100041102A1 (en) | 2006-11-07 | 2010-02-18 | Ayesha Sitlani | Antagonists of pcsk9 |
| CA2681428A1 (en) * | 2007-04-13 | 2008-10-23 | Novartis Ag | Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| JOP20080381B1 (ar) | 2007-08-23 | 2023-03-28 | Amgen Inc | بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9) |
| SG2013014352A (en) | 2007-10-26 | 2014-09-26 | Merck Sharp & Dohme | Anti-pcsk9 and methods for treating lipid and cholesterol disorders |
| AR070316A1 (es) | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
| DE112010004626T5 (de) * | 2009-12-01 | 2012-10-18 | Metanomics Health Gmbh | Mittel und Verfahren zur Diagnose von multipler Sklerose |
| EP3502707A1 (en) * | 2010-01-29 | 2019-06-26 | metanomics GmbH | Means and methods for diagnosing heart failure in a subject |
| NO2385374T3 (cg-RX-API-DMAC7.html) * | 2010-05-05 | 2014-06-07 | ||
| EP2583107A2 (en) * | 2010-06-20 | 2013-04-24 | Zora Biosciences OY | Lipidomic biomarkers for identification of high-risk coronary artery disease patients |
| EP2592422A1 (en) * | 2011-11-08 | 2013-05-15 | Zora Biosciences OY | Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients undergoing statin treatment |
| EP2592423A1 (en) * | 2011-11-08 | 2013-05-15 | Zora Biosciences OY | Lipidomic biomarkers for the prediction of cardiovascular outcomes in coronary artery disease patients not undergoing statin treatment |
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2012
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2013
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- 2013-05-24 WO PCT/EP2013/060816 patent/WO2013175016A1/en not_active Ceased
- 2013-05-24 CN CN201380027083.7A patent/CN104508488A/zh active Pending
- 2013-05-24 US US14/403,075 patent/US20160146842A2/en not_active Abandoned
- 2013-05-24 CA CA2875419A patent/CA2875419A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015526696A (ja) | 2015-09-10 |
| EP2667197A1 (en) | 2013-11-27 |
| US20160146842A2 (en) | 2016-05-26 |
| CN104508488A (zh) | 2015-04-08 |
| ES2552371T3 (es) | 2015-11-27 |
| US20150160247A1 (en) | 2015-06-11 |
| WO2013175016A1 (en) | 2013-11-28 |
| EP2667197B1 (en) | 2015-09-16 |
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