CA2869334C - Implant device and system for ablation of a renal arterial wall from the inside - Google Patents
Implant device and system for ablation of a renal arterial wall from the inside Download PDFInfo
- Publication number
- CA2869334C CA2869334C CA2869334A CA2869334A CA2869334C CA 2869334 C CA2869334 C CA 2869334C CA 2869334 A CA2869334 A CA 2869334A CA 2869334 A CA2869334 A CA 2869334A CA 2869334 C CA2869334 C CA 2869334C
- Authority
- CA
- Canada
- Prior art keywords
- implant
- temperature
- ablation
- coil
- use according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007943 implant Substances 0.000 title claims abstract description 484
- 238000002679 ablation Methods 0.000 title claims abstract description 154
- 210000002254 renal artery Anatomy 0.000 claims abstract description 64
- 230000005291 magnetic effect Effects 0.000 claims description 120
- 238000010438 heat treatment Methods 0.000 claims description 97
- 230000003902 lesion Effects 0.000 claims description 16
- 208000037849 arterial hypertension Diseases 0.000 claims description 14
- 230000008859 change Effects 0.000 claims description 14
- 210000005036 nerve Anatomy 0.000 claims description 14
- 230000002889 sympathetic effect Effects 0.000 claims description 13
- 230000000903 blocking effect Effects 0.000 claims description 11
- 230000001419 dependent effect Effects 0.000 claims description 11
- 238000002513 implantation Methods 0.000 claims description 7
- 230000001939 inductive effect Effects 0.000 claims description 6
- 230000004907 flux Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 66
- 239000000463 material Substances 0.000 description 61
- 239000000126 substance Substances 0.000 description 39
- 238000004873 anchoring Methods 0.000 description 24
- 238000000576 coating method Methods 0.000 description 21
- 229910045601 alloy Inorganic materials 0.000 description 20
- 239000000956 alloy Substances 0.000 description 20
- 239000011248 coating agent Substances 0.000 description 19
- 230000004913 activation Effects 0.000 description 18
- 229910052751 metal Inorganic materials 0.000 description 18
- 239000002184 metal Substances 0.000 description 18
- 210000004369 blood Anatomy 0.000 description 17
- 239000008280 blood Substances 0.000 description 17
- 230000005294 ferromagnetic effect Effects 0.000 description 17
- 238000011282 treatment Methods 0.000 description 16
- 238000004804 winding Methods 0.000 description 14
- 230000006698 induction Effects 0.000 description 13
- 239000000696 magnetic material Substances 0.000 description 13
- 230000005284 excitation Effects 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 230000001965 increasing effect Effects 0.000 description 11
- 239000012530 fluid Substances 0.000 description 10
- 229910001092 metal group alloy Inorganic materials 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 230000036760 body temperature Effects 0.000 description 8
- -1 nnargatoxin Chemical compound 0.000 description 8
- 239000002245 particle Substances 0.000 description 8
- 206010020772 Hypertension Diseases 0.000 description 7
- 239000002885 antiferromagnetic material Substances 0.000 description 7
- AIFRHYZBTHREPW-UHFFFAOYSA-N cis-beta-Carboline Acid Natural products N1=CC=C2C3=CC=CC=C3NC2=C1 AIFRHYZBTHREPW-UHFFFAOYSA-N 0.000 description 7
- SDZRWUKZFQQKKV-JHADDHBZSA-N cytochalasin D Natural products C([C@H]1[C@@H]2[C@@H](C([C@@H](O)[C@H]\3[C@]2([C@@H](/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/3)OC(C)=O)C(=O)N1)=C)C)C1=CC=CC=C1 SDZRWUKZFQQKKV-JHADDHBZSA-N 0.000 description 7
- AWJUIBRHMBBTKR-UHFFFAOYSA-N iso-quinoline Natural products C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 7
- 229910052759 nickel Inorganic materials 0.000 description 7
- 238000011084 recovery Methods 0.000 description 7
- ISNYUQWBWALXEY-UHFFFAOYSA-N Batrachotoxin Natural products C=1CC2(C3=CCC4C5(C)CCC(C4)(O)OC53C(O)C3)OCCN(C)CC32C=1C(C)OC(=O)C=1C(C)=CNC=1C ISNYUQWBWALXEY-UHFFFAOYSA-N 0.000 description 6
- 101000997271 Centruroides noxius Potassium channel toxin alpha-KTx 1.11 Proteins 0.000 description 6
- 108010023798 Charybdotoxin Proteins 0.000 description 6
- 101000723297 Dendroaspis polylepis polylepis Calciseptin Proteins 0.000 description 6
- 101001049894 Leiurus hebraeus Potassium channel toxin alpha-KTx 5.1 Proteins 0.000 description 6
- 229930012538 Paclitaxel Natural products 0.000 description 6
- 108010084950 Tx3 neurotoxin Proteins 0.000 description 6
- 230000005290 antiferromagnetic effect Effects 0.000 description 6
- CNVQLPPZGABUCM-LIGYZCPXSA-N ctx toxin Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]3CSSC[C@@H](C(N[C@@H](CC=4C5=CC=CC=C5NC=4)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC3=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CO)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3NC=NC=3)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N2)C(C)C)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC1=O)=O)CCSC)C(C)C)[C@@H](C)O)NC(=O)[C@H]1NC(=O)CC1)C1=CC=CC=C1 CNVQLPPZGABUCM-LIGYZCPXSA-N 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 229930195712 glutamate Natural products 0.000 description 6
- 230000005415 magnetization Effects 0.000 description 6
- 229960001592 paclitaxel Drugs 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- MXWDLLUGULWYIQ-BFRWRHKQSA-N scyllatoxin Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1N=CNC=1)C(N)=O)NC(=O)[C@H](C)N)C1=CC=CC=C1 MXWDLLUGULWYIQ-BFRWRHKQSA-N 0.000 description 6
- IYKSHBADGOZWIF-UTPLJIOFSA-N slotoxin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C(C)C)C(O)=O)NC(=O)[C@@H](N)[C@@H](C)O)C1=CC=CC=C1 IYKSHBADGOZWIF-UTPLJIOFSA-N 0.000 description 6
- 238000001356 surgical procedure Methods 0.000 description 6
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 6
- 229950010357 tetrodotoxin Drugs 0.000 description 6
- CFMYXEVWODSLAX-UHFFFAOYSA-N tetrodotoxin Natural products C12C(O)NC(=N)NC2(C2O)C(O)C3C(CO)(O)C1OC2(O)O3 CFMYXEVWODSLAX-UHFFFAOYSA-N 0.000 description 6
- ISNYUQWBWALXEY-OMIQOYQYSA-N tsg6xhx09r Chemical compound O([C@@H](C)C=1[C@@]23CN(C)CCO[C@]3(C3=CC[C@H]4[C@]5(C)CC[C@@](C4)(O)O[C@@]53[C@H](O)C2)CC=1)C(=O)C=1C(C)=CNC=1C ISNYUQWBWALXEY-OMIQOYQYSA-N 0.000 description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
- 206010029350 Neurotoxicity Diseases 0.000 description 5
- 206010044221 Toxic encephalopathy Diseases 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 230000005670 electromagnetic radiation Effects 0.000 description 5
- 230000017074 necrotic cell death Effects 0.000 description 5
- 230000007135 neurotoxicity Effects 0.000 description 5
- 231100000228 neurotoxicity Toxicity 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 230000001960 triggered effect Effects 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 4
- 210000003484 anatomy Anatomy 0.000 description 4
- 210000001367 artery Anatomy 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- 230000036642 wellbeing Effects 0.000 description 4
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 3
- 229910052688 Gadolinium Inorganic materials 0.000 description 3
- 229910001308 Zinc ferrite Inorganic materials 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000005292 diamagnetic effect Effects 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 229910003271 Ni-Fe Inorganic materials 0.000 description 2
- 244000208734 Pisonia aculeata Species 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 238000009529 body temperature measurement Methods 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 230000005672 electromagnetic field Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 239000012774 insulation material Substances 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 229910052748 manganese Inorganic materials 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 229910001000 nickel titanium Inorganic materials 0.000 description 2
- HLXZNVUGXRDIFK-UHFFFAOYSA-N nickel titanium Chemical compound [Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ti].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni].[Ni] HLXZNVUGXRDIFK-UHFFFAOYSA-N 0.000 description 2
- 238000013021 overheating Methods 0.000 description 2
- 229910052763 palladium Inorganic materials 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- GTSCNQPMGNAJSH-YHFCJVPQSA-N (2S)-2-[[(2S)-2-[[(4R,7S,10S,16S,19R)-19-[[(3S,6S,9S,12S,15S,21R,26R,29S,32S,35S,38S,41S)-21-[[2-[[(1R,2aR,4S,7S,9aS,10S,12aS,13S,15aS,16S,18aS,19S,22S,25S,28S,31S,34S,37S,40S,43S,46S,52R,57R,60S,63S,66S,69S,72S,75S,81S,84S,87S,90S,93S,96S,99S)-7,63,90-tris(4-aminobutyl)-2a-[[(2S,3S)-2-[[(2S)-2-amino-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-12a-(2-amino-2-oxoethyl)-25-(3-amino-3-oxopropyl)-13-benzyl-16,37,96-tris[(2S)-butan-2-yl]-19,28,46,72-tetrakis(3-carbamimidamidopropyl)-15a,31,43-tris(2-carboxyethyl)-9a,22,60,66-tetrakis[(1R)-1-hydroxyethyl]-40,84-bis(hydroxymethyl)-4,34,99-tris[(4-hydroxyphenyl)methyl]-93-(1H-imidazol-5-ylmethyl)-69,87-dimethyl-81-(2-methylpropyl)-10-(2-methylsulfanylethyl)-1a,2,5,8,8a,11,11a,14,14a,17,17a,20,20a,23,26,29,32,35,38,41,44,47,50,59,62,65,68,71,74,80,83,86,89,92,95,98-hexatriacontaoxo-18a-propan-2-yl-4a,5a,54,55-tetrathia-a,3,6,7a,9,10a,12,13a,15,16a,18,19a,21,24,27,30,33,36,39,42,45,48,51,58,61,64,67,70,73,79,82,85,88,91,94,97-hexatriacontazatricyclo[55.49.14.075,79]icosahectane-52-carbonyl]amino]acetyl]amino]-35-(3-amino-3-oxopropyl)-29-(2-carboxyethyl)-12,32-bis[(1R)-1-hydroxyethyl]-38-[(4-hydroxyphenyl)methyl]-3-(1H-indol-3-ylmethyl)-9-methyl-6-(2-methylsulfanylethyl)-2,5,8,11,14,20,28,31,34,37,40-undecaoxo-23,24-dithia-1,4,7,10,13,19,27,30,33,36,39-undecazatricyclo[39.3.0.015,19]tetratetracontane-26-carbonyl]amino]-16-(4-aminobutyl)-7-(3-carbamimidamidopropyl)-10-(carboxymethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-4-amino-4-oxobutanoyl]amino]-6-aminohexanoic acid Chemical compound CC[C@H](C)[C@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc3ccc(O)cc3)NC2=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)C(=O)NCC(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H]3CCCN3C(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C2=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@H]2CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC2=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O GTSCNQPMGNAJSH-YHFCJVPQSA-N 0.000 description 1
- RKMGOUZXGHZLBJ-SSDOTTSWSA-N (R)-N-Methylsalsolinol Chemical compound OC1=C(O)C=C2[C@@H](C)N(C)CCC2=C1 RKMGOUZXGHZLBJ-SSDOTTSWSA-N 0.000 description 1
- 229910052684 Cerium Inorganic materials 0.000 description 1
- 229910052692 Dysprosium Inorganic materials 0.000 description 1
- 229910052691 Erbium Inorganic materials 0.000 description 1
- 229910000640 Fe alloy Inorganic materials 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 229910052689 Holmium Inorganic materials 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 208000000348 Masked Hypertension Diseases 0.000 description 1
- 229910003322 NiCu Inorganic materials 0.000 description 1
- 229910005883 NiSi Inorganic materials 0.000 description 1
- 206010065226 Non-dipping Diseases 0.000 description 1
- 229910021118 PdCo Inorganic materials 0.000 description 1
- 229910052777 Praseodymium Inorganic materials 0.000 description 1
- 229910000676 Si alloy Inorganic materials 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- 208000005434 White Coat Hypertension Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 238000010420 art technique Methods 0.000 description 1
- 229910002056 binary alloy Inorganic materials 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- IVMYJDGYRUAWML-UHFFFAOYSA-N cobalt(II) oxide Inorganic materials [Co]=O IVMYJDGYRUAWML-UHFFFAOYSA-N 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000002591 computed tomography Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000005574 cross-species transmission Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000007773 growth pattern Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052746 lanthanum Inorganic materials 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 229910001004 magnetic alloy Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000000041 neuroadrenergic effect Effects 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 210000003492 pulmonary vein Anatomy 0.000 description 1
- 229910002059 quaternary alloy Inorganic materials 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229910052761 rare earth metal Inorganic materials 0.000 description 1
- 150000002910 rare earth metals Chemical group 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229910002058 ternary alloy Inorganic materials 0.000 description 1
- CFMYXEVWODSLAX-QOZOJKKESA-N tetrodotoxin Chemical compound O([C@@]([C@H]1O)(O)O[C@H]2[C@@]3(O)CO)[C@H]3[C@@H](O)[C@]11[C@H]2[C@@H](O)N=C(N)N1 CFMYXEVWODSLAX-QOZOJKKESA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229910000314 transition metal oxide Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/08—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by means of electrically-heated probes
- A61B18/082—Probes or electrodes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00404—Blood vessels other than those in or around the heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00434—Neural system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00505—Urinary tract
- A61B2018/00511—Kidney
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00666—Sensing and controlling the application of energy using a threshold value
- A61B2018/00678—Sensing and controlling the application of energy using a threshold value upper
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/0072—Current
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plasma & Fusion (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Otolaryngology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Magnetic Treatment Devices (AREA)
- Surgical Instruments (AREA)
- Materials For Medical Uses (AREA)
- Physical Vapour Deposition (AREA)
- Electrotherapy Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2012/055999 | 2012-04-02 | ||
| PCT/EP2012/055999 WO2012131107A1 (en) | 2011-04-01 | 2012-04-02 | System, device and method for ablation of a vessel's wall from the inside |
| PCT/EP2012/069382 WO2013149684A1 (en) | 2012-04-02 | 2012-10-01 | Implant device and system for ablation of a renal arterial wall from the inside |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2869334A1 CA2869334A1 (en) | 2013-10-10 |
| CA2869334C true CA2869334C (en) | 2022-10-04 |
Family
ID=46968210
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2869334A Active CA2869334C (en) | 2012-04-02 | 2012-10-01 | Implant device and system for ablation of a renal arterial wall from the inside |
| CA2869332A Active CA2869332C (en) | 2012-04-02 | 2012-10-01 | Implant device and system for ablation of a vessel's wall from the inside |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2869332A Active CA2869332C (en) | 2012-04-02 | 2012-10-01 | Implant device and system for ablation of a vessel's wall from the inside |
Country Status (8)
| Country | Link |
|---|---|
| JP (2) | JP2015513968A (enExample) |
| CN (2) | CN104507533B (enExample) |
| AU (2) | AU2012376021B2 (enExample) |
| CA (2) | CA2869334C (enExample) |
| IL (2) | IL234950B (enExample) |
| IN (2) | IN2014KN02365A (enExample) |
| WO (2) | WO2013149683A1 (enExample) |
| ZA (1) | ZA201407476B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9867622B2 (en) * | 2014-04-11 | 2018-01-16 | Microvention, Inc. | Implant delivery system |
| EP3244966B1 (en) * | 2015-01-12 | 2020-05-06 | Medtronic, Inc. | Methods, implantable medical leads, and related systems to monitor and limit temperature changes in proximty to electrodes |
| EP3362005B1 (en) | 2015-10-15 | 2020-12-16 | Medical Development Technologies S.A. | Improved implant device |
| US10119837B2 (en) | 2016-07-06 | 2018-11-06 | Biosense Webster (Israel) Ltd. | Magnetic-field generating circuit for a tracking system |
| EP3496640B1 (en) * | 2016-08-12 | 2020-05-06 | Medical Development Technologies S.A. | Blood-flow interrupting means for insulating an implant device for ablation |
| DK3500334T3 (da) * | 2016-08-18 | 2023-10-09 | Novocure Gmbh | Temperaturmåling i arrays til levering af ttfields |
| CN108652734B (zh) * | 2017-03-27 | 2025-01-28 | 上海宏桐实业有限公司 | 用于心脏射频消融治疗的射频发生治疗装置 |
| US11179564B2 (en) | 2017-04-25 | 2021-11-23 | Washington University | Resorbable implant for stimulating tissue, systems including such implant, and methods of using |
| US12114863B2 (en) | 2018-12-05 | 2024-10-15 | Microvention, Inc. | Implant delivery system |
| CN113476184A (zh) * | 2021-06-02 | 2021-10-08 | 北京科技大学 | 一种制备磁性生物植入件的方法 |
| US12342998B2 (en) * | 2022-04-29 | 2025-07-01 | Coherex Medical, Inc. | Sensor enabled left atrial appendage occlusion system for three-dimensional imaging and method thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7235096B1 (en) | 1998-08-25 | 2007-06-26 | Tricardia, Llc | Implantable device for promoting repair of a body lumen |
| US7594913B2 (en) * | 1998-12-14 | 2009-09-29 | Medwaves, Inc. | Radio-frequency based catheter system and method for ablating biological tissues |
| GR1003340B (el) | 1999-02-15 | 2000-03-09 | Μεθοδος και διαταξη εξωτερικης αναιμακτης θερμανσης μεταλλικων ναρθηκων με την χρηση εναλλασσομενου μαγνητικου πεδιου | |
| US6632223B1 (en) | 2000-03-30 | 2003-10-14 | The General Hospital Corporation | Pulmonary vein ablation stent and method |
| US6805695B2 (en) * | 2000-04-04 | 2004-10-19 | Spinalabs, Llc | Devices and methods for annular repair of intervertebral discs |
| US6802857B1 (en) * | 2000-10-11 | 2004-10-12 | Uab Research Foundation | MRI stent |
| US6786918B1 (en) | 2000-10-17 | 2004-09-07 | Medtronic Vascular, Inc. | Stent delivery system |
| DE10113659B4 (de) * | 2001-03-21 | 2006-10-26 | Triton BioSystems Inc., Chelmsford | Metallischer medizinischer Stent |
| EP1450711A1 (en) * | 2001-10-29 | 2004-09-01 | Triton Biosystems Inc. | Systems containing temperature regulated medical devices, and methods related thereto |
| WO2003082403A2 (en) * | 2002-03-27 | 2003-10-09 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control via coupled electrodes |
| US7367970B2 (en) * | 2003-11-11 | 2008-05-06 | Biosense Webster Inc. | Externally applied RF for pulmonary vein isolation |
| US7613523B2 (en) * | 2003-12-11 | 2009-11-03 | Apsara Medical Corporation | Aesthetic thermal sculpting of skin |
| JP2008508024A (ja) * | 2004-07-28 | 2008-03-21 | アーディアン インコーポレイテッド | 腎神経ブロッキング方法及び装置 |
| CA2582160A1 (en) * | 2004-10-08 | 2006-04-20 | Sinus Rhythm Technologies, Inc. | Two-stage scar generation for treating atrial fibrillation |
| CN100435763C (zh) * | 2005-11-04 | 2008-11-26 | 中国科学院理化技术研究所 | 结合热籽及血管支架实现血管内加热的肿瘤全身热疗装置 |
| US11395694B2 (en) * | 2009-05-07 | 2022-07-26 | St. Jude Medical, Llc | Irrigated ablation catheter with multiple segmented ablation electrodes |
| JP5263894B2 (ja) * | 2008-01-10 | 2013-08-14 | 国立大学法人秋田大学 | 感温磁性体を用いた温度計測方法及び温度制御方法 |
| CN102740925B (zh) * | 2009-10-12 | 2015-02-18 | 科纳医药股份有限公司 | 神经的能量调节 |
| ES2757726T3 (es) * | 2010-04-26 | 2020-04-30 | Medtronic Ardian Luxembourg | Aparatos y sistemas de catéter para la neuromodulación renal |
| US8473067B2 (en) * | 2010-06-11 | 2013-06-25 | Boston Scientific Scimed, Inc. | Renal denervation and stimulation employing wireless vascular energy transfer arrangement |
| CN202044343U (zh) * | 2011-04-15 | 2011-11-23 | 深圳市惠泰医疗器械有限公司 | 肾动脉射频消融导管 |
-
2012
- 2012-10-01 WO PCT/EP2012/069380 patent/WO2013149683A1/en not_active Ceased
- 2012-10-01 IN IN2365KON2014 patent/IN2014KN02365A/en unknown
- 2012-10-01 WO PCT/EP2012/069382 patent/WO2013149684A1/en not_active Ceased
- 2012-10-01 IN IN2364KON2014 patent/IN2014KN02364A/en unknown
- 2012-10-01 CA CA2869334A patent/CA2869334C/en active Active
- 2012-10-01 JP JP2015503772A patent/JP2015513968A/ja active Pending
- 2012-10-01 CN CN201280073667.3A patent/CN104507533B/zh active Active
- 2012-10-01 CN CN201280073670.5A patent/CN104507534B/zh active Active
- 2012-10-01 AU AU2012376021A patent/AU2012376021B2/en active Active
- 2012-10-01 AU AU2012375973A patent/AU2012375973B2/en active Active
- 2012-10-01 JP JP2015503771A patent/JP2015513967A/ja active Pending
- 2012-10-01 CA CA2869332A patent/CA2869332C/en active Active
-
2014
- 2014-10-02 IL IL234950A patent/IL234950B/en active IP Right Grant
- 2014-10-02 IL IL234951A patent/IL234951B/en active IP Right Grant
- 2014-10-15 ZA ZA2014/07476A patent/ZA201407476B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL234950B (en) | 2019-09-26 |
| JP2015513968A (ja) | 2015-05-18 |
| ZA201407476B (en) | 2019-12-18 |
| AU2012376021A1 (en) | 2014-10-30 |
| WO2013149684A1 (en) | 2013-10-10 |
| CN104507534A (zh) | 2015-04-08 |
| CN104507533B (zh) | 2017-01-18 |
| CA2869334A1 (en) | 2013-10-10 |
| AU2012375973B2 (en) | 2017-11-23 |
| JP2015513967A (ja) | 2015-05-18 |
| WO2013149683A1 (en) | 2013-10-10 |
| CN104507534B (zh) | 2017-10-03 |
| IN2014KN02365A (enExample) | 2015-05-01 |
| CA2869332A1 (en) | 2013-10-10 |
| IN2014KN02364A (enExample) | 2015-05-01 |
| AU2012375973A1 (en) | 2014-10-30 |
| CN104507533A (zh) | 2015-04-08 |
| AU2012376021B2 (en) | 2017-11-23 |
| IL234950A0 (en) | 2014-12-31 |
| CA2869332C (en) | 2022-07-26 |
| IL234951B (en) | 2019-08-29 |
| IL234951A0 (en) | 2014-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6415655B2 (ja) | 腎動脈を内部から焼灼するインプラント装置及びシステム | |
| CA2869334C (en) | Implant device and system for ablation of a renal arterial wall from the inside | |
| EP2833967B1 (en) | Implant device and system for ablation of a renal arterial wall from the inside | |
| EP2833968B1 (en) | Implant device and system for ablation of a vessel's wall from the inside |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20170831 |
|
| EEER | Examination request |
Effective date: 20170831 |
|
| EEER | Examination request |
Effective date: 20170831 |