CA2849661A1 - Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists - Google Patents
Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists Download PDFInfo
- Publication number
- CA2849661A1 CA2849661A1 CA2849661A CA2849661A CA2849661A1 CA 2849661 A1 CA2849661 A1 CA 2849661A1 CA 2849661 A CA2849661 A CA 2849661A CA 2849661 A CA2849661 A CA 2849661A CA 2849661 A1 CA2849661 A1 CA 2849661A1
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- Prior art keywords
- optionally substituted
- formula
- methyl
- amino
- pyrazol
- Prior art date
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- Abandoned
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- 229940121359 adenosine receptor antagonist Drugs 0.000 title claims abstract description 28
- 239000000296 purinergic P1 receptor antagonist Substances 0.000 title claims abstract description 28
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- 208000019423 liver disease Diseases 0.000 title claims abstract description 26
- 238000011282 treatment Methods 0.000 claims abstract description 29
- 239000003814 drug Substances 0.000 claims abstract description 21
- 231100000334 hepatotoxic Toxicity 0.000 claims abstract description 19
- 230000003082 hepatotoxic effect Effects 0.000 claims abstract description 18
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- 206010019799 Hepatitis viral Diseases 0.000 claims abstract description 8
- 201000001862 viral hepatitis Diseases 0.000 claims abstract description 8
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78357506P | 2006-03-17 | 2006-03-17 | |
| US60/783,575 | 2006-03-17 | ||
| CA2646333A CA2646333C (en) | 2006-03-17 | 2007-03-16 | Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2646333A Division CA2646333C (en) | 2006-03-17 | 2007-03-16 | Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2849661A1 true CA2849661A1 (en) | 2007-09-27 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2646333A Active CA2646333C (en) | 2006-03-17 | 2007-03-16 | Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists |
| CA2849661A Abandoned CA2849661A1 (en) | 2006-03-17 | 2007-03-16 | Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2646333A Active CA2646333C (en) | 2006-03-17 | 2007-03-16 | Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US7795268B2 (enExample) |
| EP (1) | EP1996201A2 (enExample) |
| JP (2) | JP5250848B2 (enExample) |
| KR (1) | KR101428113B1 (enExample) |
| CN (1) | CN101405003B (enExample) |
| AU (1) | AU2007227021B2 (enExample) |
| CA (2) | CA2646333C (enExample) |
| IL (1) | IL194158A0 (enExample) |
| MX (1) | MX2008011828A (enExample) |
| NO (1) | NO20083968L (enExample) |
| NZ (1) | NZ571324A (enExample) |
| RU (1) | RU2457842C2 (enExample) |
| WO (1) | WO2007109547A2 (enExample) |
| ZA (1) | ZA200807894B (enExample) |
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| US20080194593A1 (en) * | 2001-11-09 | 2008-08-14 | Rao Kalla | A2b adenosine receptor antagonists |
| US7317017B2 (en) * | 2002-11-08 | 2008-01-08 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US20080318983A1 (en) * | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
| RU2357969C2 (ru) * | 2003-08-25 | 2009-06-10 | АДЕНОЗАЙН ТЕРАПЬЮТИКС, ЭлЭлСи | Новые замещенные 8-гетероарилксантины и фармацевтическая композиция на их основе |
| NZ589657A (en) | 2004-10-15 | 2012-06-29 | Gilead Palo Alto Inc | Method of preventing and treating airway remodeling and pulmonary inflammation using A2B adenosine receptor antagonists |
| WO2006091936A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines |
| WO2006091898A2 (en) * | 2005-02-25 | 2006-08-31 | Adenosine Therapeutics, Llc | Pyrazolyl substituted xanthines |
| US7579348B2 (en) * | 2005-02-25 | 2009-08-25 | Pgxhealth, Llc | Derivatives of 8-substituted xanthines |
| NZ564326A (en) * | 2005-06-16 | 2010-01-29 | Cv Therapeutics Inc | Prodrugs of A2B adenosine receptor antagonists |
| US7795268B2 (en) | 2006-03-17 | 2010-09-14 | Gilead Palo Alto, Inc. | Method of treating hepatic disease using A2B adenosine receptor antagonists |
| US7884100B2 (en) * | 2006-06-16 | 2011-02-08 | Pgxhealth, Llc | Substituted 8-[6-amino-3-pyridyl]xanthines |
| CA2657973A1 (en) * | 2006-06-27 | 2008-01-03 | Biovitrum Ab (Publ) | Therapeutic compounds |
| US7767685B2 (en) * | 2006-06-29 | 2010-08-03 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2B receptor antagonists |
| EP2217233B1 (en) * | 2007-10-26 | 2018-08-08 | New York University School of Medicine | Methods and compositions for treating hepatic diseases |
| US7875608B2 (en) * | 2007-12-17 | 2011-01-25 | Thompson Robert D | Substituted 8-[6-amino-3pyridyl]xanthines |
| EP2268641B1 (en) * | 2008-03-26 | 2014-09-03 | Advinus Therapeutics Pvt. Ltd. | Heterocyclic compounds as adenosine receptor antagonist |
| CA2755117C (en) | 2009-03-13 | 2018-09-11 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds |
| WO2011055391A1 (en) | 2009-11-09 | 2011-05-12 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds, its preparation and uses thereof |
| CA2810625C (en) | 2010-09-13 | 2018-01-23 | Advinus Therapeutics Private Limited | Purine compounds as prodrugs of a2b adenosine receptor antagonists, their process and medicinal applications |
| US20140142113A1 (en) * | 2012-11-09 | 2014-05-22 | Michael W. Burnet | Method of treating inflammatory diseases using adenosine 2b receptor antagonists |
| US10583102B2 (en) | 2014-10-06 | 2020-03-10 | The Johns Hopkins University | Targeting liver nuclear receptors as a treatment for wilson disease |
| WO2016129760A1 (ko) * | 2015-02-13 | 2016-08-18 | 한국과학기술원 | Tnp(n2-(m-trifluorobenzyl), n6-(p-nitrobenzyl)purine)를 유효성분으로 함유하는 아세트아미노펜 유래 간 독성 예방 및 치료용 조성물 |
| KR101666605B1 (ko) | 2015-02-13 | 2016-10-18 | 한국과학기술원 | TNP(N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine)를 유효성분으로 함유하는 아세트아미노펜 유래 간 독성 예방 및 치료용 조성물 |
| EP3900786A1 (en) | 2015-10-29 | 2021-10-27 | CLS Therapeutics Limited | Use of dnase to improve safety and efficacy of cancer radiotherapy or chemotherapy |
| WO2017139455A1 (en) | 2016-02-10 | 2017-08-17 | Wake Forest University Health Sciences | Model system of liver fibrosis and method of making and using the same |
| KR101709307B1 (ko) * | 2016-10-31 | 2017-02-23 | 퓨쳐메디신 주식회사 | 아데노신 유도체를 포함하는 비알콜성 지방간염, 간섬유증 및 간경변증 예방 및 치료용 약학적 조성물 |
| ES2951809T3 (es) * | 2017-05-17 | 2023-10-25 | Arcus Biosciences Inc | Derivados de quinazolina-pirazol para el tratamiento de trastornos relacionados con el cáncer |
| CA3073915A1 (en) * | 2017-08-31 | 2019-03-07 | Corvus Pharmaceuticals, Inc. | Compounds and methods for modulating adenosine a2b receptor and adenosine a2a receptor |
| CA3093234A1 (en) | 2018-03-05 | 2019-09-12 | Teon Therapeutics, Inc. | Adenosine receptor antagonists and uses thereof |
| GB201804922D0 (en) | 2018-03-27 | 2018-05-09 | Ucl Business Plc | Traatment |
| CN112996509B (zh) * | 2018-07-27 | 2024-10-01 | 艾库斯生物科学有限公司 | 吡啶酮a2r拮抗剂 |
| CN111686239B (zh) * | 2019-03-11 | 2021-12-24 | 中国科学院微生物研究所 | 抗真菌化合物的应用 |
| US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
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| GB0028383D0 (en) * | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
| US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| RU2318824C2 (ru) * | 2001-11-09 | 2008-03-10 | Си Ви Терапьютикс, Инк. | Антагонисты рецептора аденозина a2b, фармацевтическая композиция на их основе и способ их получения |
| ES2208063B1 (es) * | 2002-04-01 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de la 4-(pirrolopirimidin-6-il)bencenosulfonamida. |
| AU2003245380A1 (en) * | 2002-05-30 | 2003-12-19 | King Pharmaceuticals Research & Development, Inc. | Pharmaceutically active compounds having a tricyclic pyrazolotriazolopyrimidine ring structure and methods of use |
| WO2004086052A2 (en) | 2003-03-28 | 2004-10-07 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with g-protein-coupled receptor adenosine a2b (adora2b) |
| GB0401336D0 (en) * | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| NZ564326A (en) * | 2005-06-16 | 2010-01-29 | Cv Therapeutics Inc | Prodrugs of A2B adenosine receptor antagonists |
| US7795268B2 (en) * | 2006-03-17 | 2010-09-14 | Gilead Palo Alto, Inc. | Method of treating hepatic disease using A2B adenosine receptor antagonists |
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2007
- 2007-03-16 US US11/687,236 patent/US7795268B2/en active Active
- 2007-03-16 WO PCT/US2007/064182 patent/WO2007109547A2/en not_active Ceased
- 2007-03-16 RU RU2008137279/15A patent/RU2457842C2/ru active
- 2007-03-16 MX MX2008011828A patent/MX2008011828A/es active IP Right Grant
- 2007-03-16 CA CA2646333A patent/CA2646333C/en active Active
- 2007-03-16 KR KR1020087022707A patent/KR101428113B1/ko active Active
- 2007-03-16 AU AU2007227021A patent/AU2007227021B2/en active Active
- 2007-03-16 EP EP07758704A patent/EP1996201A2/en not_active Withdrawn
- 2007-03-16 JP JP2009501667A patent/JP5250848B2/ja active Active
- 2007-03-16 CN CN2007800095071A patent/CN101405003B/zh active Active
- 2007-03-16 CA CA2849661A patent/CA2849661A1/en not_active Abandoned
- 2007-03-16 NZ NZ571324A patent/NZ571324A/en unknown
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2008
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- 2008-09-17 IL IL194158A patent/IL194158A0/en unknown
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2010
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2012
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- 2012-12-07 JP JP2012268193A patent/JP2013049719A/ja active Pending
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2013
- 2013-10-04 US US14/046,847 patent/US20140243358A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110184002A1 (en) | 2011-07-28 |
| CA2646333A1 (en) | 2007-09-27 |
| WO2007109547A2 (en) | 2007-09-27 |
| MX2008011828A (es) | 2008-09-29 |
| CA2646333C (en) | 2014-06-17 |
| JP2013049719A (ja) | 2013-03-14 |
| RU2457842C2 (ru) | 2012-08-10 |
| KR20080107416A (ko) | 2008-12-10 |
| CN101405003B (zh) | 2011-05-11 |
| NZ571324A (en) | 2011-07-29 |
| ZA200807894B (en) | 2009-05-27 |
| CN101405003A (zh) | 2009-04-08 |
| KR101428113B1 (ko) | 2014-08-07 |
| US20140243358A1 (en) | 2014-08-28 |
| WO2007109547A3 (en) | 2007-11-29 |
| US20120220608A1 (en) | 2012-08-30 |
| US7795268B2 (en) | 2010-09-14 |
| AU2007227021A1 (en) | 2007-09-27 |
| AU2007227021B2 (en) | 2012-12-20 |
| RU2008137279A (ru) | 2010-03-27 |
| NO20083968L (no) | 2008-12-15 |
| JP2009530413A (ja) | 2009-08-27 |
| US8609671B2 (en) | 2013-12-17 |
| EP1996201A2 (en) | 2008-12-03 |
| JP5250848B2 (ja) | 2013-07-31 |
| US8188099B2 (en) | 2012-05-29 |
| IL194158A0 (en) | 2009-08-03 |
| US20070219221A1 (en) | 2007-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20151021 |
|
| FZDE | Discontinued |
Effective date: 20180316 |