CA2847871C - Methods for improving the pharmacokinetics of hiv integrase inhibitors - Google Patents
Methods for improving the pharmacokinetics of hiv integrase inhibitors Download PDFInfo
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- CA2847871C CA2847871C CA2847871A CA2847871A CA2847871C CA 2847871 C CA2847871 C CA 2847871C CA 2847871 A CA2847871 A CA 2847871A CA 2847871 A CA2847871 A CA 2847871A CA 2847871 C CA2847871 C CA 2847871C
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Landscapes
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| CA2635468A CA2635468C (en) | 2005-12-30 | 2006-12-29 | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20090233964A1 (en) * | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| EP2118082B1 (en) | 2007-02-23 | 2014-10-01 | Gilead Sciences, Inc. | Modulators of pharmacokinetic properties of therapeutics |
| CA2692101A1 (en) * | 2007-06-29 | 2009-01-08 | Gilead Sciences, Inc. | Combination of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and a compound that inhibits a ugt pathway or ugt metabolism |
| AU2008270634B2 (en) * | 2007-06-29 | 2014-01-16 | Gilead Sciences, Inc. | Therapeutic compositions and the use thereof |
| GB2470494B (en) * | 2008-01-17 | 2012-08-08 | Univ Holy Ghost Duquesne | Antiretroviral drug formulations for treatment of children exposed to HIV/AIDS |
| EA032868B1 (ru) * | 2010-01-27 | 2019-07-31 | Вайв Хелткер Компани | Комбинация для лечения вич-инфекции |
| US8703786B2 (en) * | 2011-12-07 | 2014-04-22 | Texas Southern University | Etravirine formulations and uses thereof |
| MX344879B (es) | 2012-12-21 | 2017-01-11 | Gilead Sciences Inc | Compuestos de carbamoilpiridona policiclicos y su uso farmaceutico. |
| LT3019503T (lt) | 2013-07-12 | 2017-11-27 | Gilead Sciences, Inc. | Policikliniai karbamoilpiridono junginiai ir jų panaudojimas živ infekcijų gydymui |
| NO2865735T3 (enExample) | 2013-07-12 | 2018-07-21 | ||
| TWI744723B (zh) | 2014-06-20 | 2021-11-01 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (enExample) | 2014-06-20 | 2018-06-23 | ||
| TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| LT3236972T (lt) | 2014-12-26 | 2021-11-10 | Emory University | Antivirusiniai n4-hidroksicitidino dariniai |
| CA2980362C (en) | 2015-04-02 | 2020-02-25 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| KR102606625B1 (ko) | 2015-11-09 | 2023-11-27 | 길리애드 사이언시즈, 인코포레이티드 | 인간 면역결핍 바이러스의 치료를 위한 치료 조성물 |
| LT3706762T (lt) | 2017-12-07 | 2024-12-27 | Emory University | N4-hidroksicitidinas ir jo dariniai bei susiję naudojimo prieš virusus būdai |
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| US5696270A (en) | 1989-05-23 | 1997-12-09 | Abbott Laboratories | Intermediate for making retroviral protease inhibiting compounds |
| US5354866A (en) | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| EP1090914B1 (en) * | 1992-12-29 | 2003-01-02 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5567823A (en) | 1995-06-06 | 1996-10-22 | Abbott Laboratories | Process for the preparation of an HIV protease inhibiting compound |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| CA2371109C (en) * | 1999-06-04 | 2011-04-26 | Laman A. Alani | Improved pharmaceutical formulations |
| US6541515B2 (en) * | 2000-08-09 | 2003-04-01 | Merck & Co., Inc. | HIV integrase inhibitors |
| US6407128B1 (en) * | 2001-12-03 | 2002-06-18 | Elan Pharmaceuticals, Inc. | Method for increasing the bioavailability of metaxalone |
| AR037797A1 (es) * | 2001-12-12 | 2004-12-01 | Tibotec Pharm Ltd | Combinacion de inhibidores de proteasa dependientes del citocromo p450 |
| AU2003301439A1 (en) | 2002-10-16 | 2004-05-04 | Gilead Sciences, Inc. | Pre-organized tricyclic integrase inhibitor compounds |
| JP3567162B1 (ja) * | 2002-11-20 | 2004-09-22 | 日本たばこ産業株式会社 | ４−オキソキノリン化合物及びそのｈｉｖインテグラーゼ阻害剤としての利用 |
| SI1564210T1 (sl) * | 2002-11-20 | 2010-01-29 | Japan Tobacco Inc | 4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze |
| CA2513141A1 (en) * | 2003-01-27 | 2004-08-12 | Pfizer Inc. | Hiv-integrase inhibitors, pharmaceutical compositions, and methods for their use |
| JP2006528694A (ja) | 2003-05-13 | 2006-12-21 | スミスクライン ビーチャム コーポレーション | ナフチリジンインテグラーゼインヒビター |
| WO2005113509A1 (en) * | 2004-05-20 | 2005-12-01 | Japan Tobacco Inc. | Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor |
| MY134672A (en) * | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| US8633219B2 (en) | 2004-05-21 | 2014-01-21 | Japan Tobacco Inc. | Combination therapy |
| EP1891089B1 (en) * | 2005-06-02 | 2014-11-05 | Merck Sharp & Dohme Corp. | HCV protease inhibitors in combination with food |
| US20090233964A1 (en) * | 2005-12-30 | 2009-09-17 | Gilead Sciences, Inc. | Methods for improving the pharmacokinetics of hiv integrase inhibitors |
| CN105503721A (zh) * | 2006-09-12 | 2016-04-20 | 吉里德科学公司 | 制备整合酶抑制剂的方法和中间体 |
| CA2692101A1 (en) * | 2007-06-29 | 2009-01-08 | Gilead Sciences, Inc. | Combination of 6-(3-chloro-2-fluorobenzyl)-1-[(2s)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid and a compound that inhibits a ugt pathway or ugt metabolism |
| AU2008270634B2 (en) * | 2007-06-29 | 2014-01-16 | Gilead Sciences, Inc. | Therapeutic compositions and the use thereof |
| AR068403A1 (es) * | 2007-09-11 | 2009-11-18 | Gilead Sciences Inc | Proceso e intermediarios para la preparacion de inhibidores de integrasa |
-
2006
- 2006-12-29 EA EA200801619A patent/EA018544B1/ru unknown
- 2006-12-29 US US11/647,858 patent/US20070219243A1/en not_active Abandoned
- 2006-12-29 EP EP06848393A patent/EP1976517A1/en not_active Withdrawn
- 2006-12-29 HR HR20080313A patent/HRP20080313A2/xx not_active Application Discontinuation
- 2006-12-29 SG SG201102229-0A patent/SG170796A1/en unknown
- 2006-12-29 AP AP2008004522A patent/AP2702A/xx active
- 2006-12-29 KR KR1020167016288A patent/KR20160074018A/ko not_active Ceased
- 2006-12-29 CN CN201410249622.8A patent/CN104069108A/zh active Pending
- 2006-12-29 CA CA2635468A patent/CA2635468C/en active Active
- 2006-12-29 NZ NZ569576A patent/NZ569576A/en unknown
- 2006-12-29 KR KR1020147014797A patent/KR20140082858A/ko not_active Ceased
- 2006-12-29 WO PCT/US2006/049668 patent/WO2007079260A1/en not_active Ceased
- 2006-12-29 EA EA201201496A patent/EA201201496A1/ru unknown
- 2006-12-29 CA CA2847871A patent/CA2847871C/en active Active
- 2006-12-29 KR KR1020087018651A patent/KR101524165B1/ko active Active
- 2006-12-29 BR BRPI0620865-7A patent/BRPI0620865A2/pt not_active IP Right Cessation
- 2006-12-29 JP JP2008548784A patent/JP4676536B2/ja active Active
- 2006-12-29 EP EP20100193364 patent/EP2308490A1/en not_active Withdrawn
- 2006-12-29 AU AU2006332664A patent/AU2006332664B2/en active Active
- 2006-12-29 SG SG201102227-4A patent/SG170795A1/en unknown
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2008
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- 2008-07-29 NO NO20083333A patent/NO20083333L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AP2008004522A0 (en) | 2008-06-30 |
| CA2635468A1 (en) | 2007-07-12 |
| KR20140082858A (ko) | 2014-07-02 |
| JP4676536B2 (ja) | 2011-04-27 |
| WO2007079260A9 (en) | 2007-08-30 |
| JP2009525265A (ja) | 2009-07-09 |
| EA200801619A1 (ru) | 2008-10-30 |
| SG170795A1 (en) | 2011-05-30 |
| KR20160074018A (ko) | 2016-06-27 |
| CA2847871A1 (en) | 2007-07-12 |
| EA201201496A1 (ru) | 2013-07-30 |
| HRP20080313A2 (en) | 2008-11-30 |
| AU2006332664B2 (en) | 2013-03-14 |
| EA018544B1 (ru) | 2013-08-30 |
| EP1976517A1 (en) | 2008-10-08 |
| SG170796A1 (en) | 2011-05-30 |
| CA2635468C (en) | 2016-08-09 |
| NZ569576A (en) | 2011-09-30 |
| IL192208A0 (en) | 2009-02-11 |
| EP2308490A1 (en) | 2011-04-13 |
| AU2006332664A1 (en) | 2007-07-12 |
| AP2702A (en) | 2013-07-23 |
| WO2007079260A1 (en) | 2007-07-12 |
| US20070219243A1 (en) | 2007-09-20 |
| IL192208A (en) | 2013-10-31 |
| BRPI0620865A2 (pt) | 2011-11-29 |
| CN104069108A (zh) | 2014-10-01 |
| NO20083333L (no) | 2008-09-29 |
| KR20080081358A (ko) | 2008-09-09 |
| KR101524165B1 (ko) | 2015-06-01 |
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