CA2829039C - Effective amounts of (3ar)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate and methods thereof - Google Patents
Effective amounts of (3ar)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate and methods thereof Download PDFInfo
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- CA2829039C CA2829039C CA2829039A CA2829039A CA2829039C CA 2829039 C CA2829039 C CA 2829039C CA 2829039 A CA2829039 A CA 2829039A CA 2829039 A CA2829039 A CA 2829039A CA 2829039 C CA2829039 C CA 2829039C
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/041,211 US20120225922A1 (en) | 2011-03-04 | 2011-03-04 | Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration |
| US13/041,211 | 2011-03-04 | ||
| PCT/US2012/026984 WO2012154285A1 (en) | 2011-03-04 | 2012-02-28 | Effective amounts of (3ar)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl phenylcarbamate and methods thereof |
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| CA2829039A1 CA2829039A1 (en) | 2012-11-15 |
| CA2829039C true CA2829039C (en) | 2021-09-14 |
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| US20120225922A1 (en) | 2011-03-04 | 2012-09-06 | Qr Pharma | Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration |
| EP3334425B1 (en) * | 2015-08-14 | 2020-12-16 | QR Pharma | Methods of treatment or prevention of acute brain or nerve injuries |
| US20180338950A1 (en) * | 2017-05-24 | 2018-11-29 | Qr Pharma, Inc. | Prevention or Treatment of Disease States Due to Metal Dis-Homeostasis Via Administration of Posiphen to Healthy or Sick Humans |
| WO2020061404A1 (en) * | 2018-09-21 | 2020-03-26 | Aristea Translational Medicine Corporation | Compositions and methods for inhibiting brain trauma-induced neurodegeneration and related conditions |
| JP7455831B2 (ja) | 2018-11-21 | 2024-03-26 | アイオーニス ファーマシューティカルズ， インコーポレーテッド | プリオン発現を低減するための化合物及び方法 |
| JP2022550608A (ja) * | 2019-10-02 | 2022-12-02 | サンガモ セラピューティクス， インコーポレイテッド | プリオン病の治療のためのジンクフィンガータンパク質転写因子 |
| WO2022245843A1 (en) * | 2021-05-18 | 2022-11-24 | Annovis Bio, Inc. | Inhibition of neurological injuries due to infections via administration of butanetap and analogs thereof |
| EP4486892A2 (en) * | 2022-02-28 | 2025-01-08 | Ionis Pharmaceuticals, Inc. | Rnai agents of prion expression |
| WO2024123663A1 (en) * | 2022-12-06 | 2024-06-13 | Sri International | Antimicrobial compounds |
| WO2024263878A2 (en) * | 2023-06-21 | 2024-12-26 | Annovis Bio, Inc. | Solid forms of posiphen d-tartrate |
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| US5409948A (en) * | 1992-11-23 | 1995-04-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method for treating cognitive disorders with phenserine |
| BR9806184A (pt) | 1997-07-09 | 2001-06-19 | Axonyx | Inibidores de butirilcolinesterase altamente seletivos para o tratamento e o diagnóstico da doença de alzheimer e demências |
| AU2001249091A1 (en) | 2000-03-03 | 2001-09-17 | Eisai Co. Ltd. | Novel methods using cholinesterase inhibitors |
| CA2465534C (en) | 2000-11-02 | 2009-10-27 | Nigel H. Greig | Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof |
| WO2003024450A1 (en) * | 2001-09-20 | 2003-03-27 | Eisai Co., Ltd. | Methods for treating prion diseases |
| US6495700B1 (en) | 2002-01-09 | 2002-12-17 | Axonyx, Inc. | Process for producing phenserine and its analog |
| US20040024043A1 (en) * | 2002-03-22 | 2004-02-05 | Nigel Greig | Method for treating cognitive disorders |
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| US20050013869A1 (en) * | 2003-07-18 | 2005-01-20 | Chaw Cheng Shu | Sustained release formulation for carbamates and a method therefor |
| US20050182044A1 (en) | 2004-02-17 | 2005-08-18 | Bruinsma Gosse B. | Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate |
| WO2005089746A1 (en) * | 2004-03-19 | 2005-09-29 | Axonyx, Inc. | Dosage titration for treatment of cognitive disorders |
| US7625942B2 (en) | 2004-03-19 | 2009-12-01 | Axonyx, Inc. | Method of treating Down syndrome |
| US20050272804A1 (en) * | 2004-06-08 | 2005-12-08 | Axonyx, Inc | Methods of delaying Alzheimer's disease progression using a beta-amyloid precursor protein inhibitor and a HMG CoA reductase inhibitor |
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| WO2008134618A2 (en) | 2007-04-27 | 2008-11-06 | The General Hospital Corporation | Novel imaging tracers for early detection and treatment of amyloid plaques caused by alzheimer's disease and related disorders |
| CN101868236A (zh) * | 2007-06-07 | 2010-10-20 | 埃杜萨药品公司 | 用于治疗胃食管返流性疾病的组合物 |
| JP4690362B2 (ja) * | 2007-07-04 | 2011-06-01 | 株式会社リコー | Ｓｉｍｄ型マイクロプロセッサおよびｓｉｍｄ型マイクロプロセッサのデータ転送方法 |
| WO2010117727A2 (en) * | 2009-03-30 | 2010-10-14 | The General Hospital Corporation | Phenserine and posiphen for treating neuropsychiatric and neurodegenerative conditions |
| US20120225922A1 (en) | 2011-03-04 | 2012-09-06 | Qr Pharma | Effective Amounts of (3aR)-1,3a,8-Trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo [2,3-b]indol-5-yl Phenylcarbamate and Methods of Treating or Preventing Neurodegeneration |
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- 2012-02-28 WO PCT/US2012/026984 patent/WO2012154285A1/en not_active Ceased
- 2012-02-28 JP JP2013557757A patent/JP2014513065A/ja not_active Withdrawn
- 2012-02-28 CN CN201280021686.1A patent/CN103582419A/zh active Pending
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2015
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2017
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Also Published As
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|---|---|
| AU2012254093B2 (en) | 2015-08-06 |
| US11382893B2 (en) | 2022-07-12 |
| US11096926B2 (en) | 2021-08-24 |
| US20200375948A1 (en) | 2020-12-03 |
| US20210093610A1 (en) | 2021-04-01 |
| BR112013022673A2 (pt) | 2017-03-28 |
| US11400075B2 (en) | 2022-08-02 |
| US20150374664A1 (en) | 2015-12-31 |
| US20250114330A1 (en) | 2025-04-10 |
| EP2683242B8 (en) | 2020-06-03 |
| US20200375947A1 (en) | 2020-12-03 |
| US20170304266A1 (en) | 2017-10-26 |
| AU2012254093A1 (en) | 2013-09-26 |
| CA2829039A1 (en) | 2012-11-15 |
| US20220323413A1 (en) | 2022-10-13 |
| EP2683242B1 (en) | 2020-04-08 |
| US12144798B2 (en) | 2024-11-19 |
| US20120225922A1 (en) | 2012-09-06 |
| WO2012154285A1 (en) | 2012-11-15 |
| KR20140019361A (ko) | 2014-02-14 |
| US11376238B2 (en) | 2022-07-05 |
| JP2014513065A (ja) | 2014-05-29 |
| DK2683242T3 (da) | 2020-07-06 |
| EP2683242A4 (en) | 2014-09-03 |
| CN103582419A (zh) | 2014-02-12 |
| US10383851B2 (en) | 2019-08-20 |
| US20190381007A1 (en) | 2019-12-19 |
| JP2018076332A (ja) | 2018-05-17 |
| EP2683242A1 (en) | 2014-01-15 |
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| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20170118 |