CA2820435C - Glycomimetic compounds as anti-infectious against pathogens lectins - Google Patents

Glycomimetic compounds as anti-infectious against pathogens lectins Download PDF

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Publication number
CA2820435C
CA2820435C CA2820435A CA2820435A CA2820435C CA 2820435 C CA2820435 C CA 2820435C CA 2820435 A CA2820435 A CA 2820435A CA 2820435 A CA2820435 A CA 2820435A CA 2820435 C CA2820435 C CA 2820435C
Authority
CA
Canada
Prior art keywords
group
calixarene
glycosylated compound
formula
based glycosylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2820435A
Other languages
English (en)
French (fr)
Other versions
CA2820435A1 (en
Inventor
Anne Imberty
Sebastien Vidal
Susan Matthews
Karine Faure
Benoit Guery
Samy Cecioni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite Lille 2 Droit et Sante
Universite Claude Bernard Lyon 1
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite Lille 2 Droit et Sante
Universite Claude Bernard Lyon 1
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Universite Lille 2 Droit et Sante, Universite Claude Bernard Lyon 1 filed Critical Centre National de la Recherche Scientifique CNRS
Publication of CA2820435A1 publication Critical patent/CA2820435A1/en
Application granted granted Critical
Publication of CA2820435C publication Critical patent/CA2820435C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA2820435A 2010-12-10 2010-12-10 Glycomimetic compounds as anti-infectious against pathogens lectins Active CA2820435C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2010/055741 WO2012076934A1 (en) 2010-12-10 2010-12-10 Glycomimetic compounds as anti-infectious against pathogens lectins

Publications (2)

Publication Number Publication Date
CA2820435A1 CA2820435A1 (en) 2012-06-14
CA2820435C true CA2820435C (en) 2017-11-28

Family

ID=43742390

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2820435A Active CA2820435C (en) 2010-12-10 2010-12-10 Glycomimetic compounds as anti-infectious against pathogens lectins

Country Status (6)

Country Link
US (1) US9023814B2 (https=)
EP (1) EP2649085B1 (https=)
JP (1) JP5774120B2 (https=)
CA (1) CA2820435C (https=)
ES (1) ES2524363T3 (https=)
WO (1) WO2012076934A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2851371A1 (en) * 2013-09-23 2015-03-25 Centre National de la Recherche Scientifique (CNRS) Glycoclusters and their pharmaceutical use as antibacterials
GB2525384A (en) * 2014-04-14 2015-10-28 Calixar Synthesis of amphiphilic calixarene glycoside detergents and use of same for extracting and stabilizing native functional membrane proteins
CN104311546A (zh) * 2014-09-12 2015-01-28 三峡大学 一种杯芳烃稀土配合物,杯芳烃稀土配合物的制备方法及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080171706A1 (en) 2004-03-23 2008-07-17 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Anti-Adhesive Compounds to Prevent and Treat Bacterial Infections
EP1928892B1 (en) 2005-08-09 2011-10-12 GlycoMimetics, Inc. Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
WO2007143052A1 (en) 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas

Also Published As

Publication number Publication date
EP2649085A1 (en) 2013-10-16
US20130252910A1 (en) 2013-09-26
US9023814B2 (en) 2015-05-05
JP2013544876A (ja) 2013-12-19
CA2820435A1 (en) 2012-06-14
ES2524363T3 (es) 2014-12-05
WO2012076934A1 (en) 2012-06-14
JP5774120B2 (ja) 2015-09-02
EP2649085B1 (en) 2014-08-20

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Legal Events

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EEER Examination request

Effective date: 20151118

H11 Ip right ceased following rejected request for revival

Free format text: ST27 STATUS EVENT CODE: T-6-6-H10-H11-H101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: TIME LIMIT FOR REVERSAL EXPIRED

Effective date: 20240724