CA2819599C - Systemes et procedes pour le traitement de la douleur par stimulation des fibres neurales - Google Patents
Systemes et procedes pour le traitement de la douleur par stimulation des fibres neurales Download PDFInfo
- Publication number
- CA2819599C CA2819599C CA2819599A CA2819599A CA2819599C CA 2819599 C CA2819599 C CA 2819599C CA 2819599 A CA2819599 A CA 2819599A CA 2819599 A CA2819599 A CA 2819599A CA 2819599 C CA2819599 C CA 2819599C
- Authority
- CA
- Canada
- Prior art keywords
- pain
- fibers
- use according
- nerve fibers
- afferent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000002193 Pain Diseases 0.000 title claims abstract description 146
- 230000036407 pain Effects 0.000 title claims abstract description 131
- 230000000638 stimulation Effects 0.000 title claims abstract description 122
- 239000000835 fiber Substances 0.000 title abstract description 95
- 238000011282 treatment Methods 0.000 title abstract description 62
- 238000000034 method Methods 0.000 title abstract description 53
- 230000001537 neural effect Effects 0.000 title abstract description 40
- 230000004913 activation Effects 0.000 claims abstract description 25
- 108091008706 proprioceptors Proteins 0.000 claims abstract description 8
- 210000004126 nerve fiber Anatomy 0.000 claims description 44
- 210000003205 muscle Anatomy 0.000 claims description 37
- 230000036982 action potential Effects 0.000 claims description 34
- 230000004044 response Effects 0.000 claims description 32
- 241001465754 Metazoa Species 0.000 claims description 22
- 210000002265 sensory receptor cell Anatomy 0.000 claims description 20
- 210000003169 central nervous system Anatomy 0.000 claims description 18
- 230000009467 reduction Effects 0.000 claims description 18
- 230000008447 perception Effects 0.000 claims description 15
- 230000004936 stimulating effect Effects 0.000 claims description 11
- 230000008602 contraction Effects 0.000 claims description 9
- 238000001727 in vivo Methods 0.000 claims description 9
- 210000000653 nervous system Anatomy 0.000 claims description 4
- 230000002829 reductive effect Effects 0.000 claims description 4
- 230000007604 neuronal communication Effects 0.000 claims description 2
- 230000025350 membrane depolarization involved in regulation of action potential Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 38
- 210000000412 mechanoreceptor Anatomy 0.000 abstract description 29
- 108020003175 receptors Proteins 0.000 abstract description 23
- 108091008704 mechanoreceptors Proteins 0.000 abstract description 15
- 108091008709 muscle spindles Proteins 0.000 abstract description 12
- 210000001087 myotubule Anatomy 0.000 abstract description 12
- 210000004699 muscle spindle Anatomy 0.000 abstract description 10
- 210000003626 afferent pathway Anatomy 0.000 abstract description 2
- 210000005036 nerve Anatomy 0.000 description 48
- 210000003050 axon Anatomy 0.000 description 30
- 102000005962 receptors Human genes 0.000 description 19
- 210000001519 tissue Anatomy 0.000 description 19
- 206010070834 Sensitisation Diseases 0.000 description 15
- 230000004118 muscle contraction Effects 0.000 description 15
- 210000003491 skin Anatomy 0.000 description 14
- 230000001953 sensory effect Effects 0.000 description 13
- 208000000094 Chronic Pain Diseases 0.000 description 11
- 230000003040 nociceptive effect Effects 0.000 description 11
- 230000003213 activating effect Effects 0.000 description 9
- 230000000670 limiting effect Effects 0.000 description 9
- 230000001473 noxious effect Effects 0.000 description 9
- 230000008313 sensitization Effects 0.000 description 9
- 210000000278 spinal cord Anatomy 0.000 description 8
- 238000007920 subcutaneous administration Methods 0.000 description 8
- 230000008859 change Effects 0.000 description 7
- 238000010304 firing Methods 0.000 description 7
- 230000036541 health Effects 0.000 description 7
- 210000001428 peripheral nervous system Anatomy 0.000 description 7
- 108091008691 sensory receptors Proteins 0.000 description 7
- 102000027509 sensory receptors Human genes 0.000 description 7
- 230000007774 longterm Effects 0.000 description 6
- 208000035824 paresthesia Diseases 0.000 description 6
- 230000035807 sensation Effects 0.000 description 6
- 230000000763 evoking effect Effects 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 238000012423 maintenance Methods 0.000 description 5
- 210000001640 nerve ending Anatomy 0.000 description 5
- 210000003607 pacinian corpuscle Anatomy 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000003068 static effect Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 238000002646 transcutaneous electrical nerve stimulation Methods 0.000 description 5
- 208000004983 Phantom Limb Diseases 0.000 description 4
- 206010056238 Phantom pain Diseases 0.000 description 4
- 208000005298 acute pain Diseases 0.000 description 4
- 238000002266 amputation Methods 0.000 description 4
- 230000002051 biphasic effect Effects 0.000 description 4
- 210000004556 brain Anatomy 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 108091008708 free nerve endings Proteins 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 206010028347 Muscle twitching Diseases 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 230000003278 mimic effect Effects 0.000 description 3
- 230000007383 nerve stimulation Effects 0.000 description 3
- 230000000926 neurological effect Effects 0.000 description 3
- 210000000929 nociceptor Anatomy 0.000 description 3
- 210000000578 peripheral nerve Anatomy 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 210000003051 thermoreceptor Anatomy 0.000 description 3
- 108091008689 thermoreceptors Proteins 0.000 description 3
- 230000002463 transducing effect Effects 0.000 description 3
- 230000008733 trauma Effects 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- 206010001497 Agitation Diseases 0.000 description 2
- 208000036829 Device dislocation Diseases 0.000 description 2
- 206010013142 Disinhibition Diseases 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 208000028389 Nerve injury Diseases 0.000 description 2
- 206010054880 Vascular insufficiency Diseases 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 210000003766 afferent neuron Anatomy 0.000 description 2
- 238000004873 anchoring Methods 0.000 description 2
- 230000000386 athletic effect Effects 0.000 description 2
- 230000006399 behavior Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000003592 biomimetic effect Effects 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000002996 emotional effect Effects 0.000 description 2
- 210000003099 femoral nerve Anatomy 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 210000000281 joint capsule Anatomy 0.000 description 2
- 230000008764 nerve damage Effects 0.000 description 2
- 108091008700 nociceptors Proteins 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000036278 prepulse Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000007115 recruitment Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 210000001032 spinal nerve Anatomy 0.000 description 2
- 230000008093 supporting effect Effects 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000000946 synaptic effect Effects 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 208000023577 vascular insufficiency disease Diseases 0.000 description 2
- 101100039010 Caenorhabditis elegans dis-3 gene Proteins 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000023890 Complex Regional Pain Syndromes Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 206010052804 Drug tolerance Diseases 0.000 description 1
- 208000027534 Emotional disease Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000034906 Medical device complication Diseases 0.000 description 1
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 description 1
- 206010049565 Muscle fatigue Diseases 0.000 description 1
- 206010029216 Nervousness Diseases 0.000 description 1
- 208000001294 Nociceptive Pain Diseases 0.000 description 1
- 241000220010 Rhode Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000003181 biological factor Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 108091008690 chemoreceptors Proteins 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000006854 communication Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 238000002567 electromyography Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 210000002585 gamma motor neuron Anatomy 0.000 description 1
- 230000026781 habituation Effects 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000030214 innervation Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000012977 invasive surgical procedure Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 210000000716 merkel cell Anatomy 0.000 description 1
- 210000000713 mesentery Anatomy 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 210000002161 motor neuron Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 210000003061 neural cell Anatomy 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 238000011369 optimal treatment Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000037324 pain perception Effects 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000009023 proprioceptive sensation Effects 0.000 description 1
- 238000013442 quality metrics Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000024977 response to activity Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000003497 sciatic nerve Anatomy 0.000 description 1
- 210000001044 sensory neuron Anatomy 0.000 description 1
- 230000009329 sexual behaviour Effects 0.000 description 1
- 230000007958 sleep Effects 0.000 description 1
- 230000003238 somatosensory effect Effects 0.000 description 1
- 230000009159 somatosensory pathway Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 210000000242 supportive cell Anatomy 0.000 description 1
- 210000001590 sural nerve Anatomy 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000026683 transduction Effects 0.000 description 1
- 238000010361 transduction Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000005641 tunneling Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 201000011531 vascular cancer Diseases 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36071—Pain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0551—Spinal or peripheral nerve electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Electrotherapy Devices (AREA)
Abstract
Des modes de réalisation de la présente invention concernent des systèmes et procédés pour le traitement de la douleur par activation de fibres neurales sélectionnées. Les fibres neurales peuvent comprendre une ou plusieurs fibres neurales afférentes et/ou une ou plusieurs fibres neurales efférentes. Si des fibres afférentes sont stimulées, seules ou combinées à des fibres efférentes, une quantité thérapeutiquement efficace est appliquée pour activer des chemins afférents d'une manière approchant l'activité afférente naturelle. Les fibres afférentes peuvent être associés à des récepteurs primaires de fuseaux musculaires, d'organes tendineux de Golgi, de récepteurs secondaire de fuseaux musculaires, de récepteurs d'articulations, de récepteurs tactiles et d'autres types de mécanorécepteurs et/ou propriorécepteurs. Si des fibres efférentes sont stimulées, seules ou combinées à des fibres afférentes, une quantité thérapeutiquement efficace est appliquée pour activer des fibres intrafusales et/ou extrafusales musculaires, ce qui résulte en une activation indirecte de fibres afférentes qui leur sont associées.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41880110P | 2010-12-01 | 2010-12-01 | |
| US41876810P | 2010-12-01 | 2010-12-01 | |
| US61/418,801 | 2010-12-01 | ||
| US61/418,768 | 2010-12-01 | ||
| PCT/US2011/062882 WO2012075281A1 (fr) | 2010-12-01 | 2011-12-01 | Systèmes et procédés pour le traitement de la douleur par stimulation des fibres neurales |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2819599A1 CA2819599A1 (fr) | 2012-06-07 |
| CA2819599C true CA2819599C (fr) | 2018-06-19 |
Family
ID=46172266
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2819602A Active CA2819602C (fr) | 2010-12-01 | 2011-12-01 | Systemes et procedes de traitement de la douleur par le biais d'une stimulation neuronale des fibres |
| CA2819599A Active CA2819599C (fr) | 2010-12-01 | 2011-12-01 | Systemes et procedes pour le traitement de la douleur par stimulation des fibres neurales |
| CA2819596A Active CA2819596C (fr) | 2010-12-01 | 2011-12-01 | Systemes et procedes pour le traitement de la douleur grace a la stimulation de fibres nerveuses |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2819602A Active CA2819602C (fr) | 2010-12-01 | 2011-12-01 | Systemes et procedes de traitement de la douleur par le biais d'une stimulation neuronale des fibres |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2819596A Active CA2819596C (fr) | 2010-12-01 | 2011-12-01 | Systemes et procedes pour le traitement de la douleur grace a la stimulation de fibres nerveuses |
Country Status (3)
| Country | Link |
|---|---|
| AU (3) | AU2011336506B2 (fr) |
| CA (3) | CA2819602C (fr) |
| WO (3) | WO2012075281A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8788048B2 (en) | 2010-11-11 | 2014-07-22 | Spr Therapeutics, Llc | Systems and methods for the treatment of pain through neural fiber stimulation |
| US8788047B2 (en) | 2010-11-11 | 2014-07-22 | Spr Therapeutics, Llc | Systems and methods for the treatment of pain through neural fiber stimulation |
| US8788046B2 (en) | 2010-11-11 | 2014-07-22 | Spr Therapeutics, Llc | Systems and methods for the treatment of pain through neural fiber stimulation |
| CA2958199C (fr) | 2014-08-15 | 2023-03-07 | Axonics Modulation Technologies, Inc. | Positionnement d'une derivation electromyographique et titrage de la stimulation dans un systeme de stimulation nerveuse pour le traitement de la vessie hyperactive |
| AU2015301402B2 (en) | 2014-08-15 | 2020-06-04 | Axonics Modulation Technologies, Inc. | Integrated electromyographic clinician programmer for use with an implantable neurostimulator |
| JP6878269B2 (ja) | 2014-08-15 | 2021-05-26 | アクソニクス モジュレーション テクノロジーズ インコーポレイテッド | 神経位置特定に基づく神経刺激電極構成のためのシステムおよび方法 |
| US11540973B2 (en) | 2016-10-21 | 2023-01-03 | Spr Therapeutics, Llc | Method and system of mechanical nerve stimulation for pain relief |
| MX2020002413A (es) * | 2017-09-06 | 2020-09-17 | Linde Eng North America Inc | Metodos para proporcionar refrigeracion en plantas de recuperacion de liquidos del gas natural. |
| WO2020242900A1 (fr) | 2019-05-24 | 2020-12-03 | Axonics Modulation Technologies, Inc. | Dispositif d'entraînement pour un programmateur de neurostimulateur et procédés associés d'utilisation avec un système de neurostimulation |
| US11439829B2 (en) | 2019-05-24 | 2022-09-13 | Axonics, Inc. | Clinician programmer methods and systems for maintaining target operating temperatures |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6167304A (en) * | 1993-05-28 | 2000-12-26 | Loos; Hendricus G. | Pulse variability in electric field manipulation of nervous systems |
| US5653739A (en) * | 1995-09-13 | 1997-08-05 | Empi, Inc. | Electronic pain feedback system and method |
| US8626302B2 (en) * | 1998-06-03 | 2014-01-07 | Spr Therapeutics, Llc | Systems and methods to place one or more leads in muscle for providing electrical stimulation to treat pain |
| US6600954B2 (en) * | 2001-01-25 | 2003-07-29 | Biocontrol Medical Bcm Ltd. | Method and apparatus for selective control of nerve fibers |
| US6735475B1 (en) * | 2001-01-30 | 2004-05-11 | Advanced Bionics Corporation | Fully implantable miniature neurostimulator for stimulation as a therapy for headache and/or facial pain |
| US6892098B2 (en) * | 2001-04-26 | 2005-05-10 | Biocontrol Medical Ltd. | Nerve stimulation for treating spasticity, tremor, muscle weakness, and other motor disorders |
| DE60224677T2 (de) * | 2001-08-17 | 2009-01-08 | Advanced Bionics Corp., Sylmar | Allmähliche rekrutierung von erregbarem muskel/nerven-gewebe unter verwendung elektrischer stimulationsparameter mit hoher rate |
| ATE542566T1 (de) * | 2002-10-15 | 2012-02-15 | Medtronic Inc | Kanalselektive verdeckung für ein medizinisches system |
| US8219189B2 (en) * | 2004-12-01 | 2012-07-10 | Penny Knoblich | Method and apparatus for improving renal function |
| US7979131B2 (en) * | 2006-01-26 | 2011-07-12 | Advanced Neuromodulation Systems, Inc. | Method of neurostimulation of distinct neural structures using single paddle lead to treat multiple pain locations and multi-column, multi-row paddle lead for such neurostimulation |
| AU2007293613A1 (en) * | 2006-09-08 | 2008-03-13 | Ull Meter A/S | Method of utilising measurements of threshold of pain |
| US8805518B2 (en) * | 2008-05-09 | 2014-08-12 | Medtronic, Inc. | Peripheral nerve field stimulation control |
| JP5688024B2 (ja) * | 2008-10-15 | 2015-03-25 | ニューヴェイジヴ，インコーポレイテッド | 神経生理学的監視システム |
| CA3153124C (fr) * | 2008-12-05 | 2024-05-14 | Joseph W. Ii Boggs | Systemes et procedes pour placer une ou plusieurs derivations dans un tissu pour stimuler electriquement des nerfs de passage pour traiter la douleur |
-
2011
- 2011-12-01 CA CA2819602A patent/CA2819602C/fr active Active
- 2011-12-01 CA CA2819599A patent/CA2819599C/fr active Active
- 2011-12-01 CA CA2819596A patent/CA2819596C/fr active Active
- 2011-12-01 WO PCT/US2011/062882 patent/WO2012075281A1/fr active Application Filing
- 2011-12-01 AU AU2011336506A patent/AU2011336506B2/en active Active
- 2011-12-01 WO PCT/US2011/062906 patent/WO2012075299A1/fr active Application Filing
- 2011-12-01 AU AU2011336490A patent/AU2011336490B2/en active Active
- 2011-12-01 AU AU2011336430A patent/AU2011336430B2/en active Active
- 2011-12-01 WO PCT/US2011/062857 patent/WO2012075265A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012075299A1 (fr) | 2012-06-07 |
| CA2819602C (fr) | 2020-02-25 |
| WO2012075265A1 (fr) | 2012-06-07 |
| AU2011336490A1 (en) | 2013-07-04 |
| AU2011336490B2 (en) | 2016-04-28 |
| AU2011336430B2 (en) | 2016-09-29 |
| WO2012075281A1 (fr) | 2012-06-07 |
| AU2011336430A1 (en) | 2013-07-04 |
| AU2011336506B2 (en) | 2015-10-08 |
| CA2819596A1 (fr) | 2012-06-07 |
| CA2819602A1 (fr) | 2012-06-07 |
| CA2819596C (fr) | 2018-02-27 |
| CA2819599A1 (fr) | 2012-06-07 |
| AU2011336506A1 (en) | 2013-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11612746B2 (en) | Systems and methods for the treatment of pain through neural fiber stimulation | |
| US20210106829A1 (en) | Systems and methods for the treatment of pain through neural fiber stimulation | |
| US20190015663A1 (en) | Systems and methods for the treatment of pain through neural fiber stimulation | |
| CA2819599C (fr) | Systemes et procedes pour le traitement de la douleur par stimulation des fibres neurales | |
| JP2014506501A (ja) | 運動障害の標的治療のための装置、システム、および方法 | |
| AU2016200012B2 (en) | Systems and methods for the treatment of pain through neural fiber stimulation | |
| US20240131343A1 (en) | Peripheral nerve and spinal cord differential target multiplexed stimulation | |
| US20240066304A1 (en) | Ratiometric control for electrical stimulation | |
| JP2022551604A (ja) | むずむず脚症候群のための末梢神経刺激 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20161130 |