CA2810831C - Method for non-invasive analysis of a substance concentration within a body - Google Patents
Method for non-invasive analysis of a substance concentration within a body Download PDFInfo
- Publication number
- CA2810831C CA2810831C CA2810831A CA2810831A CA2810831C CA 2810831 C CA2810831 C CA 2810831C CA 2810831 A CA2810831 A CA 2810831A CA 2810831 A CA2810831 A CA 2810831A CA 2810831 C CA2810831 C CA 2810831C
- Authority
- CA
- Canada
- Prior art keywords
- temperature
- wavelength band
- normalized
- substance
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000126 substance Substances 0.000 title claims abstract description 53
- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000004458 analytical method Methods 0.000 title description 4
- 230000005855 radiation Effects 0.000 claims abstract description 50
- 238000005259 measurement Methods 0.000 claims description 30
- 238000010521 absorption reaction Methods 0.000 claims description 17
- 238000011084 recovery Methods 0.000 claims description 12
- 230000003287 optical effect Effects 0.000 claims description 10
- 238000001228 spectrum Methods 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims 2
- 230000001747 exhibiting effect Effects 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 15
- 239000008103 glucose Substances 0.000 abstract description 15
- 230000006870 function Effects 0.000 description 12
- 238000001816 cooling Methods 0.000 description 11
- 238000010438 heat treatment Methods 0.000 description 10
- 230000008859 change Effects 0.000 description 9
- 238000010586 diagram Methods 0.000 description 6
- 239000000470 constituent Substances 0.000 description 5
- 238000000862 absorption spectrum Methods 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 230000036760 body temperature Effects 0.000 description 4
- 238000000295 emission spectrum Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000002329 infrared spectrum Methods 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 230000004913 activation Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000012306 spectroscopic technique Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1491—Heated applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Optics & Photonics (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Radiation Pyrometers (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/883,063 US20110004080A1 (en) | 2008-04-11 | 2010-09-15 | Method for non-invasive analysis of a substance concentration within a body |
| US12/883,063 | 2010-09-15 | ||
| PCT/US2011/051218 WO2012037029A1 (en) | 2010-09-15 | 2011-09-12 | Method for non-invasive analysis of a substance concentration within a body |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2810831A1 CA2810831A1 (en) | 2012-03-22 |
| CA2810831C true CA2810831C (en) | 2017-11-21 |
Family
ID=45831923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2810831A Expired - Fee Related CA2810831C (en) | 2010-09-15 | 2011-09-12 | Method for non-invasive analysis of a substance concentration within a body |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20110004080A1 (enExample) |
| EP (2) | EP2615975A4 (enExample) |
| JP (2) | JP5752796B2 (enExample) |
| CN (2) | CN107647872A (enExample) |
| AU (1) | AU2011302301C1 (enExample) |
| BR (1) | BR112013005648A2 (enExample) |
| CA (1) | CA2810831C (enExample) |
| RU (1) | RU2562173C2 (enExample) |
| WO (1) | WO2012037029A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9681832B2 (en) | 2008-04-11 | 2017-06-20 | Glucovista Inc. | Measurement apparatuses and methods using a combined substance cooling device |
| JP6594302B2 (ja) * | 2013-06-23 | 2019-10-23 | グルコビスタ・インコーポレイテッド | 吸熱反応を用いて冷却装置を使用する物質の濃度測定 |
| JP6600635B2 (ja) * | 2014-01-10 | 2019-10-30 | グルコビスタ・インコーポレイテッド | 物質濃度を測定するための非侵襲的なシステムおよび方法 |
| US10588552B2 (en) | 2014-06-19 | 2020-03-17 | Glucovista Inc. | Substance concentration analysis methods and apparatuses |
| US10617337B2 (en) | 2014-06-19 | 2020-04-14 | Glucovista Inc. | Substance concentration monitoring apparatuses and methods |
| JP6704924B2 (ja) * | 2015-03-16 | 2020-06-03 | グルコビスタ・インコーポレイテッド | 物質濃度補正システムおよび方法 |
| CN107427232B (zh) * | 2015-03-16 | 2021-03-02 | 格鲁科威斯塔公司 | 物质浓度校正系统和方法 |
| JP6451525B2 (ja) * | 2015-06-25 | 2019-01-16 | 花王株式会社 | 経表皮水分蒸散量の変化量の推定方法 |
| KR101977401B1 (ko) * | 2015-09-03 | 2019-05-13 | 엘에스산전 주식회사 | 동적 모드버스 프로토콜 매핑을 지원하는 통신 장치 |
| RU2644501C2 (ru) * | 2016-02-09 | 2018-02-12 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Тамбовский государственный технический университет" (ФГБОУ ВО ТГТУ) | Способ неинвазивного определения концентрации глюкозы в крови по глюкограмме |
| CN110662481B (zh) | 2017-05-19 | 2023-01-03 | 格鲁科威斯塔公司 | 物质浓度nir监测设备和方法 |
| CN107242855A (zh) * | 2017-06-05 | 2017-10-13 | 天津大学 | 一种生物组织动态调制光谱测量装置及方法 |
| US11559230B2 (en) * | 2018-01-23 | 2023-01-24 | Dexcom, Inc. | Systems, devices, and methods to compensate for temperature effects on sensors |
| KR102033711B1 (ko) * | 2018-02-19 | 2019-11-08 | 주식회사 템퍼스 | 비침습식 혈당 측정 방법 및 비침습식 혈당 측정 장치 |
| KR102213701B1 (ko) * | 2019-07-16 | 2021-02-08 | 에스케이하이닉스 주식회사 | 온도 감지 장치 및 이를 이용한 온도 감지 시스템 |
| AU2020331683B2 (en) * | 2019-08-16 | 2025-08-14 | Glucomat Gmbh | Active miniaturized sensing system and method |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3770958A (en) * | 1972-01-05 | 1973-11-06 | Honeywell Inc | Infrared radiation detection by a matched system |
| ATE42673T1 (de) | 1984-05-04 | 1989-05-15 | Kurashiki Boseki Kk | Spektrophotometrisches geraet zur unblutigen bestimmung von glukose in lebendem gewebe. |
| JPH0827235B2 (ja) | 1987-11-17 | 1996-03-21 | 倉敷紡績株式会社 | 糖類濃度の分光学的測定法 |
| US4882492A (en) | 1988-01-19 | 1989-11-21 | Biotronics Associates, Inc. | Non-invasive near infrared measurement of blood analyte concentrations |
| US5191215A (en) | 1989-01-13 | 1993-03-02 | Iowa State University Research Foundation, Inc. | Apparatus and method for transient thermal infrared spectrometry of flowable enclosed materials |
| US5028787A (en) * | 1989-01-19 | 1991-07-02 | Futrex, Inc. | Non-invasive measurement of blood glucose |
| US5237178A (en) * | 1990-06-27 | 1993-08-17 | Rosenthal Robert D | Non-invasive near-infrared quantitative measurement instrument |
| CA2028261C (en) * | 1989-10-28 | 1995-01-17 | Won Suck Yang | Non-invasive method and apparatus for measuring blood glucose concentration |
| US5370114A (en) * | 1992-03-12 | 1994-12-06 | Wong; Jacob Y. | Non-invasive blood chemistry measurement by stimulated infrared relaxation emission |
| US5515847A (en) * | 1993-01-28 | 1996-05-14 | Optiscan, Inc. | Self-emission noninvasive infrared spectrophotometer |
| US5313941A (en) * | 1993-01-28 | 1994-05-24 | Braig James R | Noninvasive pulsed infrared spectrophotometer |
| US5615672A (en) * | 1993-01-28 | 1997-04-01 | Optiscan, Inc. | Self-emission noninvasive infrared spectrophotometer with body temperature compensation |
| US6072180A (en) * | 1995-10-17 | 2000-06-06 | Optiscan Biomedical Corporation | Non-invasive infrared absorption spectrometer for the generation and capture of thermal gradient spectra from living tissue |
| US5666956A (en) * | 1996-05-20 | 1997-09-16 | Buchert; Janusz Michal | Instrument and method for non-invasive monitoring of human tissue analyte by measuring the body's infrared radiation |
| US5900632A (en) * | 1997-03-12 | 1999-05-04 | Optiscan Biomedical Corporation | Subsurface thermal gradient spectrometry |
| US6161028A (en) | 1999-03-10 | 2000-12-12 | Optiscan Biomedical Corporation | Method for determining analyte concentration using periodic temperature modulation and phase detection |
| US6002953A (en) * | 1998-05-06 | 1999-12-14 | Optix Lp | Non-invasive IR transmission measurement of analyte in the tympanic membrane |
| US6526298B1 (en) * | 1998-05-18 | 2003-02-25 | Abbott Laboratories | Method for the non-invasive determination of analytes in a selected volume of tissue |
| AU759282B2 (en) * | 1998-12-23 | 2003-04-10 | Medispectra, Inc. | Systems and methods for optical examination of samples |
| US6198949B1 (en) * | 1999-03-10 | 2001-03-06 | Optiscan Biomedical Corporation | Solid-state non-invasive infrared absorption spectrometer for the generation and capture of thermal gradient spectra from living tissue |
| US6633771B1 (en) * | 1999-03-10 | 2003-10-14 | Optiscan Biomedical Corporation | Solid-state non-invasive thermal cycling spectrometer |
| US6647350B1 (en) * | 2000-06-02 | 2003-11-11 | Exactus, Inc. | Radiometric temperature measurement system |
| US6609015B2 (en) * | 2001-01-18 | 2003-08-19 | Koninklijke Philips Electronics N.V. | Analysis of a composition |
| JP4494779B2 (ja) * | 2001-08-02 | 2010-06-30 | グルコビスタ・エルエルシー | 非侵襲グルコース計測器 |
| US6998247B2 (en) * | 2002-03-08 | 2006-02-14 | Sensys Medical, Inc. | Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers |
| US6992772B2 (en) * | 2003-06-19 | 2006-01-31 | Optix Lp | Method and apparatus for optical sampling to reduce interfering variances |
| US6954662B2 (en) * | 2003-08-19 | 2005-10-11 | A.D. Integrity Applications, Ltd. | Method of monitoring glucose level |
| US6949070B2 (en) * | 2003-08-21 | 2005-09-27 | Ishler Larry W | Non-invasive blood glucose monitoring system |
| US20050043630A1 (en) * | 2003-08-21 | 2005-02-24 | Buchert Janusz Michal | Thermal Emission Non-Invasive Analyte Monitor |
| JP3590047B1 (ja) * | 2003-09-24 | 2004-11-17 | 株式会社日立製作所 | 光学測定装置及びそれを用いた血糖値測定装置 |
| US7342082B2 (en) * | 2004-12-17 | 2008-03-11 | 3M Innovative Properties Company | Soluble polymers as amine capture agents and methods |
| JP3590053B1 (ja) | 2004-02-24 | 2004-11-17 | 株式会社日立製作所 | 血糖値測定装置 |
| US7251516B2 (en) * | 2004-05-11 | 2007-07-31 | Nostix Llc | Noninvasive glucose sensor |
| JP2007105329A (ja) * | 2005-10-14 | 2007-04-26 | Hitachi Ltd | 血糖値測定装置及び代謝量測定装置 |
| CN101346097B (zh) * | 2005-12-22 | 2010-11-03 | 皇家飞利浦电子股份有限公司 | 血糖浓度的无创测量系统 |
| WO2007100677A2 (en) * | 2006-02-22 | 2007-09-07 | Vivum Nexus Llc | Method and device for analyte measurement |
| DE102006036920B3 (de) * | 2006-08-04 | 2007-11-29 | Nirlus Engineering Ag | Verfahren zur Messung der Glukosekonzentration in pulsierendem Blut |
| US8401604B2 (en) * | 2008-04-11 | 2013-03-19 | Glucovista, Llc | Apparatus and methods for non-invasive measurement of a substance within a body |
| CN101799412B (zh) * | 2010-04-07 | 2012-04-25 | 中国科学院自动化研究所 | 无创测量人体血糖的近红外光谱透射方法及装置 |
| JP2017016168A (ja) | 2015-06-26 | 2017-01-19 | 株式会社デンソー | 情報コード生成装置、情報コード生成プログラム |
-
2010
- 2010-09-15 US US12/883,063 patent/US20110004080A1/en not_active Abandoned
-
2011
- 2011-09-12 EP EP11825737.7A patent/EP2615975A4/en not_active Withdrawn
- 2011-09-12 EP EP19208977.9A patent/EP3628223B1/en active Active
- 2011-09-12 CN CN201710799742.9A patent/CN107647872A/zh active Pending
- 2011-09-12 CN CN2011800439846A patent/CN103118594A/zh active Pending
- 2011-09-12 BR BR112013005648A patent/BR112013005648A2/pt not_active IP Right Cessation
- 2011-09-12 RU RU2013117005/14A patent/RU2562173C2/ru not_active IP Right Cessation
- 2011-09-12 AU AU2011302301A patent/AU2011302301C1/en not_active Ceased
- 2011-09-12 WO PCT/US2011/051218 patent/WO2012037029A1/en not_active Ceased
- 2011-09-12 JP JP2013529225A patent/JP5752796B2/ja active Active
- 2011-09-12 CA CA2810831A patent/CA2810831C/en not_active Expired - Fee Related
-
2015
- 2015-05-19 JP JP2015101712A patent/JP5963914B2/ja active Active
-
2018
- 2018-10-29 US US16/174,168 patent/US11141082B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5752796B2 (ja) | 2015-07-22 |
| US20190083014A1 (en) | 2019-03-21 |
| JP2015157143A (ja) | 2015-09-03 |
| EP3628223C0 (en) | 2024-10-30 |
| EP2615975A4 (en) | 2014-07-23 |
| RU2562173C2 (ru) | 2015-09-10 |
| EP3628223B1 (en) | 2024-10-30 |
| RU2013117005A (ru) | 2014-10-20 |
| CN107647872A (zh) | 2018-02-02 |
| WO2012037029A1 (en) | 2012-03-22 |
| AU2011302301A1 (en) | 2013-03-07 |
| JP2013539671A (ja) | 2013-10-28 |
| CN103118594A (zh) | 2013-05-22 |
| BR112013005648A2 (pt) | 2016-05-03 |
| EP3628223A2 (en) | 2020-04-01 |
| AU2011302301C1 (en) | 2015-07-09 |
| JP5963914B2 (ja) | 2016-08-03 |
| EP2615975A1 (en) | 2013-07-24 |
| CA2810831A1 (en) | 2012-03-22 |
| US20110004080A1 (en) | 2011-01-06 |
| AU2011302301B2 (en) | 2014-04-10 |
| US11141082B2 (en) | 2021-10-12 |
| EP3628223A3 (en) | 2020-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20130307 |
|
| MKLA | Lapsed |
Effective date: 20200914 |