CA2791144C - Procedes de criblage de proteases et proteases identifiees par lesdits procedes - Google Patents

Procedes de criblage de proteases et proteases identifiees par lesdits procedes Download PDF

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Publication number
CA2791144C
CA2791144C CA2791144A CA2791144A CA2791144C CA 2791144 C CA2791144 C CA 2791144C CA 2791144 A CA2791144 A CA 2791144A CA 2791144 A CA2791144 A CA 2791144A CA 2791144 C CA2791144 C CA 2791144C
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Canada
Prior art keywords
protease
proteases
sequence
substrate
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2791144A
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English (en)
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CA2791144A1 (fr
Inventor
Edwin L. Madison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Catalyst Biosciences Inc
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Publication date
Application filed by Catalyst Biosciences Inc filed Critical Catalyst Biosciences Inc
Priority claimed from CA2656531A external-priority patent/CA2656531C/fr
Publication of CA2791144A1 publication Critical patent/CA2791144A1/fr
Application granted granted Critical
Publication of CA2791144C publication Critical patent/CA2791144C/fr
Active legal-status Critical Current
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Des procédés pour identifier des protéases modifiées avec une spécificité de substrat modifiée ou autres propriétés sont décrits. Les procédés permettent de cribler des protéases candidates et modifiées par mise en contact de celles-ci avec un substrat, tel quune serpine, des macroglobulines alpha ou une protéine de la famille p35 ou des serpines modifiées et des membres modifiés de la famille p35 ou des macroglobulines alpha modifiées, qui, lors du clivage du substrat, piège la protéase par la formation dun complexe stable. Des protéases modifiées sont également décrites.
CA2791144A 2006-07-05 2007-07-05 Procedes de criblage de proteases et proteases identifiees par lesdits procedes Active CA2791144C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US81891006P 2006-07-05 2006-07-05
US81880406P 2006-07-05 2006-07-05
US60/818,804 2006-07-05
US60/818,910 2006-07-05
CA2656531A CA2656531C (fr) 2006-07-05 2007-07-05 Procedes de criblage de proteases et proteases identifiees par lesdits procedes

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2656531A Division CA2656531C (fr) 2006-07-05 2007-07-05 Procedes de criblage de proteases et proteases identifiees par lesdits procedes

Publications (2)

Publication Number Publication Date
CA2791144A1 CA2791144A1 (fr) 2008-04-17
CA2791144C true CA2791144C (fr) 2019-04-09

Family

ID=41040512

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2791144A Active CA2791144C (fr) 2006-07-05 2007-07-05 Procedes de criblage de proteases et proteases identifiees par lesdits procedes

Country Status (3)

Country Link
CN (2) CN107630011A (fr)
CA (1) CA2791144C (fr)
ZA (1) ZA200900394B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102181419A (zh) * 2011-01-18 2011-09-14 湖南尤特尔生化有限公司 一种里氏木霉蛋白酶及其制备方法和应用
US10781435B2 (en) * 2017-06-22 2020-09-22 Catalyst Biosciences, Inc. Modified membrane type serine protease 1 (MTSP-1) polypeptides and methods of use
JP7414281B2 (ja) * 2017-08-08 2024-01-16 クイーンズランド ユニバーシティ オブ テクノロジー 初期心不全の診断方法
CN111019925B (zh) * 2018-10-10 2022-08-23 上饶市康可得生物科技有限公司 筛选蛋白酶变体的方法以及获得的蛋白酶变体
WO2020073553A1 (fr) * 2018-10-10 2020-04-16 上饶市康可得生物科技有限公司 Procédé de criblage de variant de protéase et variant de protéase obtenu
CN111117940B (zh) * 2019-12-04 2022-06-28 天津大学 一种高产戊二胺的大肠杆菌工程菌与方法
CN111079420B (zh) * 2019-12-19 2023-04-07 天津新开心生活科技有限公司 文本识别方法、装置、计算机可读介质及电子设备
CN112662694A (zh) * 2020-12-25 2021-04-16 康九生物科技(长春)有限公司 一种麦芽糖结合蛋白、麦芽糖结合蛋白表达载体、重组工程菌及其应用
WO2024055291A1 (fr) * 2022-09-16 2024-03-21 中国科学院深圳先进技术研究院 Procédé de criblage à haut débit de mutant de sirtuine, mutant de sirtuine et son utilisation
CN116640741A (zh) * 2023-07-17 2023-08-25 河北艾欧路生物科技有限责任公司 一种从牛血清中提取肌酸激酶的方法
CN117969827A (zh) * 2024-03-28 2024-05-03 北京大学人民医院 抗caspase 14抗体在制备类风湿关节炎补充诊断产品中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030199463A1 (en) * 2002-04-23 2003-10-23 Silviu Itescu DNA enzyme to inhibit plasminogen activator inhibitor-1
ATE554097T1 (de) * 2003-10-09 2012-05-15 Kyowa Hakko Kirin Co Ltd Verfahren zur herstellung von antithrombin-iii- zusammensetzungen

Also Published As

Publication number Publication date
CN101517074B (zh) 2013-07-03
ZA200900394B (en) 2010-01-27
CN107630011A (zh) 2018-01-26
CN101517074A (zh) 2009-08-26
CA2791144A1 (fr) 2008-04-17

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