CA2789945A1 - Universal virus-like particle (vlp) influenza vaccines - Google Patents
Universal virus-like particle (vlp) influenza vaccines Download PDFInfo
- Publication number
- CA2789945A1 CA2789945A1 CA2789945A CA2789945A CA2789945A1 CA 2789945 A1 CA2789945 A1 CA 2789945A1 CA 2789945 A CA2789945 A CA 2789945A CA 2789945 A CA2789945 A CA 2789945A CA 2789945 A1 CA2789945 A1 CA 2789945A1
- Authority
- CA
- Canada
- Prior art keywords
- influenza
- vlp
- cell
- proteins
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30576810P | 2010-02-18 | 2010-02-18 | |
US30575910P | 2010-02-18 | 2010-02-18 | |
US61/305,759 | 2010-02-18 | ||
US61/305,768 | 2010-02-18 | ||
PCT/US2011/000300 WO2011102900A1 (en) | 2010-02-18 | 2011-02-18 | Universal virus-like particle (vlp) influenza vaccines |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2789945A1 true CA2789945A1 (en) | 2011-08-25 |
Family
ID=44483229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2789945A Pending CA2789945A1 (en) | 2010-02-18 | 2011-02-18 | Universal virus-like particle (vlp) influenza vaccines |
Country Status (6)
Country | Link |
---|---|
US (4) | US9352031B2 (sl) |
EP (1) | EP2536428B1 (sl) |
JP (2) | JP2013520167A (sl) |
CN (1) | CN102858368B (sl) |
CA (1) | CA2789945A1 (sl) |
WO (1) | WO2011102900A1 (sl) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
DK2610345T3 (en) | 2007-11-27 | 2015-12-07 | Medicago Inc | RECOMBINANT INFLUENZA VIRUS SIMULAR PARTICULARS (VLPS) MADE IN TRANSGENE PLANTS THAT EXPRESS HEMAGGLUTININ |
EP2536428B1 (en) * | 2010-02-18 | 2018-12-05 | Technovax, Inc. | Universal virus-like particle (vlp) influenza vaccines |
US20130209512A1 (en) * | 2010-08-16 | 2013-08-15 | Hildegund C. J. Ertl | Universal influenza a vaccines |
US9441019B2 (en) | 2011-09-23 | 2016-09-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Influenza hemagglutinin protein-based vaccines |
ES2951259T3 (es) | 2011-09-30 | 2023-10-19 | Medicago Inc | Aumento del rendimiento de las partículas similares a virus en las plantas |
US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
US20140302124A1 (en) * | 2011-10-19 | 2014-10-09 | Immunotape, Inc. | Cytotoxic T Lymphocyte Inducing Immunogens For Prevention Treatment and Diagnosis of INFLUENZA VIRUS INFECTION |
BR112014019755B1 (pt) | 2012-03-22 | 2022-02-22 | Fraunhofer Usa, Inc | Partícula do tipo viral; método de produção das partículas do tipo viral; composição imunogênica e uso das partículas do tipo viral |
EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
IL241692B2 (en) | 2013-03-28 | 2023-12-01 | Medicago Inc | Production of influenza virus-like particles in plants |
CN113667013B (zh) * | 2013-10-02 | 2024-04-09 | 免疫医疗有限责任公司 | 中和抗甲型流感抗体及其用途 |
EP3906939A1 (en) | 2013-10-11 | 2021-11-10 | The United States of America, represented by the Secretary, Department of Health and Human Services | Epstein-barr virus vaccines |
EP3089755A1 (en) | 2014-01-03 | 2016-11-09 | Fundacion Biofisica Bizkaia | VLPs, METHODS FOR THEIR OBTENTION AND APPLICATIONS THEREOF |
EP3157557A1 (en) * | 2014-06-20 | 2017-04-26 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Polyvalent influenza virus-like particles (vlps) and use as vaccines |
SG11201705264WA (en) | 2014-12-31 | 2017-07-28 | The Usa As Represented By The Secretary Detp Of Health And Human Services | Novel multivalent nanoparticle-based vaccines |
WO2017040387A2 (en) | 2015-08-31 | 2017-03-09 | Technovax, Inc. | Human respiratory syncytial virus (hrsv) virus-like particles (vlps) based vaccine |
SG10201912944QA (en) | 2016-09-02 | 2020-02-27 | The Usa As Represented By The Secretary | Stabilized group 2 influenza hemagglutinin stem region trimers and uses thereof |
MX2019014943A (es) | 2018-12-12 | 2020-08-06 | Cambridge Tech Llc | Vacuna universal contra la gripe. |
CN110272473B (zh) * | 2019-07-10 | 2021-03-02 | 军事科学院军事医学研究院军事兽医研究所 | 甲型流感通用型病毒样颗粒及其制备方法和应用 |
WO2022040220A2 (en) * | 2020-08-17 | 2022-02-24 | Technovax, Inc. | Severe acute respiratory syndrome coronavirus [sars-cov-2]-virus-like particle [vlp] vaccine: compositions, delivery strategies, methods and uses |
CN112342149A (zh) * | 2020-11-12 | 2021-02-09 | 新疆畜牧科学院兽医研究所(新疆畜牧科学院动物临床医学研究中心) | 一种禽流感病毒样颗粒组装表达系统及其应用 |
AU2022425707A1 (en) * | 2021-12-31 | 2024-07-04 | Mynvax Private Limited | Polypeptide fragments, immunogenic composition against influenza virus, and implementations thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE376059T1 (de) * | 2000-06-23 | 2007-11-15 | Wyeth Corp | Assemblierung von wildtyp und chimären influenzavirus-ähnlichen partikeln (vlps) |
US8080255B2 (en) * | 2003-07-11 | 2011-12-20 | Novavax Inc. | Functional influenza virus like particles (VLPs) |
US8592197B2 (en) * | 2003-07-11 | 2013-11-26 | Novavax, Inc. | Functional influenza virus-like particles (VLPs) |
US20060051859A1 (en) * | 2004-09-09 | 2006-03-09 | Yan Fu | Long acting human interferon analogs |
CN101227920A (zh) * | 2005-07-19 | 2008-07-23 | 陶氏环球技术公司 | 重组流感疫苗 |
CA2625406C (en) * | 2005-10-18 | 2016-08-09 | Novavax, Inc. | Functional influenza virus like particles (vlps) |
US9101578B2 (en) * | 2006-05-01 | 2015-08-11 | Technovax, Inc. | Polyvalent influenza virus-like particle (VLP) compositions |
US8778353B2 (en) * | 2006-05-01 | 2014-07-15 | Technovax, Inc. | Influenza virus-like particle (VLP) compositions |
EP2044224A4 (en) * | 2006-07-27 | 2011-04-13 | Ligocyte Pharmaceuticals Inc | CHIMERIC VIRUS TYPE PARTICLES |
WO2008061243A2 (en) * | 2006-11-16 | 2008-05-22 | Novavax, Inc. | Respiratory syncytial virus-virus like particle (vlps) |
WO2010060921A1 (en) * | 2008-11-25 | 2010-06-03 | Avir Green Hills Biotechnology Research Development Trade Ag | METHOD FOR PRODUCTION OF pH STABLE ENVELOPED VIRUSES |
JP2012521786A (ja) * | 2009-03-30 | 2012-09-20 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルスワクチン及びその使用 |
EP2536428B1 (en) * | 2010-02-18 | 2018-12-05 | Technovax, Inc. | Universal virus-like particle (vlp) influenza vaccines |
KR102072582B1 (ko) * | 2012-12-31 | 2020-02-03 | 엘지전자 주식회사 | 듀얼 디스플레이 방법 및 장치 |
-
2011
- 2011-02-18 EP EP11744998.3A patent/EP2536428B1/en not_active Not-in-force
- 2011-02-18 WO PCT/US2011/000300 patent/WO2011102900A1/en active Application Filing
- 2011-02-18 JP JP2012553903A patent/JP2013520167A/ja active Pending
- 2011-02-18 CA CA2789945A patent/CA2789945A1/en active Pending
- 2011-02-18 CN CN201180019751.2A patent/CN102858368B/zh not_active Expired - Fee Related
- 2011-02-18 US US12/932,217 patent/US9352031B2/en not_active Expired - Fee Related
-
2016
- 2016-05-06 US US15/148,699 patent/US10080796B2/en active Active
- 2016-07-01 JP JP2016131988A patent/JP6524555B2/ja not_active Expired - Fee Related
-
2018
- 2018-08-23 US US16/109,995 patent/US10695418B2/en not_active Expired - Fee Related
-
2020
- 2020-06-05 US US16/894,483 patent/US11529410B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2016198107A (ja) | 2016-12-01 |
EP2536428A4 (en) | 2014-04-09 |
US10695418B2 (en) | 2020-06-30 |
EP2536428B1 (en) | 2018-12-05 |
US20190091323A1 (en) | 2019-03-28 |
US11529410B2 (en) | 2022-12-20 |
US10080796B2 (en) | 2018-09-25 |
US20160303223A1 (en) | 2016-10-20 |
JP6524555B2 (ja) | 2019-06-05 |
WO2011102900A1 (en) | 2011-08-25 |
EP2536428A1 (en) | 2012-12-26 |
JP2013520167A (ja) | 2013-06-06 |
US20200297836A1 (en) | 2020-09-24 |
CN102858368A (zh) | 2013-01-02 |
US20110212128A1 (en) | 2011-09-01 |
US9352031B2 (en) | 2016-05-31 |
CN102858368B (zh) | 2017-04-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20160218 |
|
EEER | Examination request |
Effective date: 20160218 |
|
EEER | Examination request |
Effective date: 20160218 |
|
EEER | Examination request |
Effective date: 20160218 |
|
EEER | Examination request |
Effective date: 20160218 |
|
EEER | Examination request |
Effective date: 20160218 |