CA2784212C - Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs - Google Patents

Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs Download PDF

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Publication number
CA2784212C
CA2784212C CA2784212A CA2784212A CA2784212C CA 2784212 C CA2784212 C CA 2784212C CA 2784212 A CA2784212 A CA 2784212A CA 2784212 A CA2784212 A CA 2784212A CA 2784212 C CA2784212 C CA 2784212C
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group
ranging
carbon atoms
nanoparticle
branched
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CA2784212A
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English (en)
French (fr)
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CA2784212A1 (en
Inventor
David Brevet
Laurence Raehm
Mireille Blanchard-Desce
Olivier Mongin
Magali Gary-Bobo-Sable-Teychene
Marcel Garcia
Alain Morere
Jean-Olivier Durand
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Centre National de la Recherche Scientifique CNRS
Universite de Rennes 1
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Montpellier
Original Assignee
Centre National de la Recherche Scientifique CNRS
Universite de Rennes 1
Institut National de la Sante et de la Recherche Medicale INSERM
Universite de Montpellier
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0801General processes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/10Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2784212A 2009-12-15 2010-12-07 Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs Active CA2784212C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09306238.8 2009-12-15
EP09306238 2009-12-15
PCT/EP2010/069035 WO2011073054A1 (en) 2009-12-15 2010-12-07 Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs

Publications (2)

Publication Number Publication Date
CA2784212A1 CA2784212A1 (en) 2011-06-23
CA2784212C true CA2784212C (en) 2018-01-16

Family

ID=42021128

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2784212A Active CA2784212C (en) 2009-12-15 2010-12-07 Biphotonic photosensitizers, nanoparticles containing the same and their use as drugs

Country Status (5)

Country Link
US (1) US8709747B2 (cg-RX-API-DMAC7.html)
EP (1) EP2513083B1 (cg-RX-API-DMAC7.html)
JP (1) JP5926685B2 (cg-RX-API-DMAC7.html)
CA (1) CA2784212C (cg-RX-API-DMAC7.html)
WO (1) WO2011073054A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2988721B1 (fr) 2012-03-27 2014-04-04 Centre Nat Rech Scient Nanoparticules de silicium poreux fonctionnalisees et leurs utilisations en therapie photodynamique
FR3044676B1 (fr) * 2015-12-04 2017-11-24 Univ Rennes Dendrimeres photosensibilisateurs biphotoniques, procede de fabrication et utilisations
US20210000955A1 (en) * 2017-12-08 2021-01-07 Nanyang Technological University Photodynamically active organosilica nanoparticles and medical uses thereof
CN114504551B (zh) * 2020-11-16 2024-01-02 北京厚燊维康科技有限责任公司 可用于光动力治疗或诊断的制剂
CN117327098B (zh) * 2023-09-28 2025-11-11 江汉大学 一种以用于i型光动力治疗为主的aie型光敏剂的制备方法与应用
WO2025207959A1 (en) 2024-03-27 2025-10-02 Biogen Ma Inc. Anti-transferrin receptor antibodies and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITFI940095A1 (it) * 1994-05-23 1995-11-23 Molteni & C Coniugati fotodinamici aventi proprieta' biocide
CA2513759C (en) * 2003-01-24 2014-05-13 The Research Foundation Of State University Of New York Ceramic based nanoparticles for entrapping therapeutic agents for photodynamic therapy and method of using same
WO2008030624A2 (en) 2006-09-08 2008-03-13 The Research Foundation Of State University Of New York Nanoparticles for two-photon activated photodynamic therapy and imaging

Also Published As

Publication number Publication date
JP5926685B2 (ja) 2016-05-25
WO2011073054A1 (en) 2011-06-23
US20130065849A1 (en) 2013-03-14
EP2513083A1 (en) 2012-10-24
JP2013513632A (ja) 2013-04-22
CA2784212A1 (en) 2011-06-23
US8709747B2 (en) 2014-04-29
EP2513083B1 (en) 2016-04-06

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