CA2776581C - Methods for the prevention or treatment of heart failure - Google Patents

Methods for the prevention or treatment of heart failure Download PDF

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Publication number
CA2776581C
CA2776581C CA2776581A CA2776581A CA2776581C CA 2776581 C CA2776581 C CA 2776581C CA 2776581 A CA2776581 A CA 2776581A CA 2776581 A CA2776581 A CA 2776581A CA 2776581 C CA2776581 C CA 2776581C
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CA
Canada
Prior art keywords
arg
lys
phe
dmt
peptide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2776581A
Other languages
English (en)
French (fr)
Other versions
CA2776581A1 (en
Inventor
Hazel H. Szeto
Peter S. Rabinovitch
Dao-Fu Dai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Cornell University
Original Assignee
University of Washington
Cornell University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Cornell University filed Critical University of Washington
Publication of CA2776581A1 publication Critical patent/CA2776581A1/en
Application granted granted Critical
Publication of CA2776581C publication Critical patent/CA2776581C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1019—Tetrapeptides with the first amino acid being basic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2776581A 2009-10-05 2010-10-04 Methods for the prevention or treatment of heart failure Active CA2776581C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24868109P 2009-10-05 2009-10-05
US61/248,681 2009-10-05
US28948309P 2009-12-23 2009-12-23
US61/289,483 2009-12-23
PCT/US2010/051329 WO2011044044A1 (en) 2009-10-05 2010-10-04 Methods for the prevention or treatment of heart failure

Publications (2)

Publication Number Publication Date
CA2776581A1 CA2776581A1 (en) 2011-04-14
CA2776581C true CA2776581C (en) 2020-12-15

Family

ID=43823652

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2776581A Active CA2776581C (en) 2009-10-05 2010-10-04 Methods for the prevention or treatment of heart failure

Country Status (7)

Country Link
US (7) US20110082084A1 (https=)
EP (5) EP2485749A4 (https=)
JP (6) JP2013506696A (https=)
CN (2) CN102711785A (https=)
CA (1) CA2776581C (https=)
HK (1) HK1217293A1 (https=)
WO (1) WO2011044044A1 (https=)

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AU2013334788A1 (en) * 2012-10-22 2015-06-04 Henry Ford Health Systems Methods for reducing risks associated with heart failure and factors associated therewith
CN110339339A (zh) * 2013-03-01 2019-10-18 康德生物医疗技术公司 治疗线粒体疾病的方法
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US10047395B2 (en) * 2013-06-26 2018-08-14 Stealth Biotherapeutics Corp Methods and compositions for detecting and diagnosing diseases and conditions
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CN112111003B (zh) * 2019-06-20 2022-02-11 中国农业大学 含有me序列的一类新型抑制血小板聚集和抗血栓形成寡肽
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US20230256047A1 (en) * 2020-06-17 2023-08-17 Stealth Biotherapeutics Inc. Methods and compositions for the treatment of muscular dystrophy
CA3191819A1 (en) 2020-09-09 2022-03-17 Hazel Szeto Methods and compositions for delivery of biotin to mitochondria
CN117881411A (zh) 2021-06-01 2024-04-12 艾迪雅生物有限责任公司 用于眼部药物的延长释放药物递送系统和使用方法
CN117384253A (zh) * 2023-08-28 2024-01-12 南京医科大学 一类肽及其衍生物和应用

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Also Published As

Publication number Publication date
JP2018203764A (ja) 2018-12-27
EP3603658A1 (en) 2020-02-05
EP2485749A1 (en) 2012-08-15
JP2020097627A (ja) 2020-06-25
EP3120860A1 (en) 2017-01-25
JP7017762B2 (ja) 2022-02-09
JP2022046811A (ja) 2022-03-23
JP2013506696A (ja) 2013-02-28
US11534476B2 (en) 2022-12-27
EP3120860B1 (en) 2019-06-26
CN103845724A (zh) 2014-06-11
US20140100166A1 (en) 2014-04-10
CA2776581A1 (en) 2011-04-14
EP2485749A4 (en) 2013-07-24
JP7382607B2 (ja) 2023-11-17
US20210187056A1 (en) 2021-06-24
EP2764871A1 (en) 2014-08-13
US20230285499A1 (en) 2023-09-14
HK1217293A1 (en) 2017-01-06
EP3603658B1 (en) 2025-01-08
JP2015163609A (ja) 2015-09-10
CN102711785A (zh) 2012-10-03
JP6429835B2 (ja) 2018-11-28
US20110082084A1 (en) 2011-04-07
WO2011044044A1 (en) 2011-04-14
US20160106800A1 (en) 2016-04-21
US20200188470A1 (en) 2020-06-18
US12102659B2 (en) 2024-10-01
US20180236025A1 (en) 2018-08-23
JP2016190876A (ja) 2016-11-10
EP2944317A1 (en) 2015-11-18

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