CA2771941C - Compositions and methods for bone formation and remodeling - Google Patents
Compositions and methods for bone formation and remodeling Download PDFInfo
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- CA2771941C CA2771941C CA2771941A CA2771941A CA2771941C CA 2771941 C CA2771941 C CA 2771941C CA 2771941 A CA2771941 A CA 2771941A CA 2771941 A CA2771941 A CA 2771941A CA 2771941 C CA2771941 C CA 2771941C
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| US20030219793A1 (en) * | 2002-10-04 | 2003-11-27 | Carulli John P. | High bone mass gene of 11q13.3 |
| US7485460B2 (en) * | 2003-05-21 | 2009-02-03 | Tulane University Health Sciences Center | Enhanced growth of adult stem cells with Dkk-1 |
| US20120178697A9 (en) * | 2003-09-22 | 2012-07-12 | Jie Zheng | Compositions and methods for the inhibition of dishevelled proteins |
| US8637506B2 (en) * | 2003-09-22 | 2014-01-28 | Enzo Biochem, Inc. | Compositions and methods for bone formation and remodeling |
| US8367822B2 (en) * | 2003-09-22 | 2013-02-05 | Enzo Therapeutics, Inc. | Compositions and methods for bone formation and remodeling |
| US20100041599A1 (en) | 2006-11-14 | 2010-02-18 | Dakai Liu | Compositions and methods for bone formation, bone remodeling and toxin protection |
| US8461155B2 (en) * | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
| US9046537B2 (en) | 2003-09-22 | 2015-06-02 | Enzo Biochem, Inc. | Method for treating inflammation by administering a compound which binds LDL-receptor-related protein (LRP) ligand binding domain |
| US9052324B2 (en) * | 2004-05-19 | 2015-06-09 | Enzo Biochem, Inc. | Compounds and assays for controlling Wnt activity |
| US8343922B2 (en) * | 2004-05-19 | 2013-01-01 | Enzo Biochem, Inc. | Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells |
| CA2685737A1 (en) * | 2007-04-30 | 2008-11-06 | Washington University | Methods and compositions for the treatment of cancer |
| WO2008144659A2 (en) * | 2007-05-18 | 2008-11-27 | Board Of Regents, The University Of Texas System | Dickkopf-1 (dkk1) as a universal tumor vaccine for immunotherapy of cancers |
| EP3305324A1 (en) * | 2007-11-02 | 2018-04-11 | Novartis AG | Molecules and methods for modulating low-density-lipoprotein receptor-related protein 6 (lrp6) |
| WO2009064944A2 (en) * | 2007-11-16 | 2009-05-22 | Nuvelo, Inc. | Antibodies to lrp6 |
| US8716243B2 (en) * | 2008-05-28 | 2014-05-06 | St. Jude Childen's Research Hospital | Methods of effecting Wnt signaling through Dkk structural analysis |
| WO2010108001A2 (en) * | 2009-03-18 | 2010-09-23 | The Brigham And Women's Hospital, Inc. | Agents and methods for tissue repair and regeneration |
| NZ596274A (en) | 2009-05-12 | 2013-11-29 | Pfizer | Blocking anti-dkk-1 antibodies and their uses |
| EP2566892B1 (en) | 2010-05-06 | 2017-12-20 | Novartis AG | Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (lrp6) antibodies |
| CA2798390A1 (en) | 2010-05-06 | 2011-11-10 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies |
| US11167011B2 (en) | 2010-06-07 | 2021-11-09 | Enzo Biochem, Inc. | Methods for treating bone loss using sclerostin peptides |
| US9617323B2 (en) | 2010-06-07 | 2017-04-11 | Joshua Rabbani | Sulfonated sclerostin, antibodies, epitopes and methods for identification and use therefor |
| US9493541B2 (en) | 2010-06-07 | 2016-11-15 | Joshua Rabbani | Antibodies specific for sulfated sclerostin |
| US9403882B2 (en) | 2010-06-07 | 2016-08-02 | Joshua Rabbani | Sulfation of Wnt pathway proteins |
| BR112013017711A2 (pt) * | 2011-01-11 | 2016-08-23 | Fate Therapeutics Inc | novas composições de wnt e usos terapêuticos de tais composições |
| KR101303941B1 (ko) | 2011-03-31 | 2013-09-05 | 연세대학교 산학협력단 | 피마자 추출물을 유효성분으로 함유하는 골 질환 예방 및 치료용 조성물 |
| EP3290442A1 (en) | 2011-11-04 | 2018-03-07 | Novartis AG | Low density lipoprotein-related protein 6 (lrp6) half-life extender constructs |
| CN103966229A (zh) * | 2014-05-09 | 2014-08-06 | 中山大学 | bbeAMP基因、其编码的蛋白质、以bbeAMP为目的基因生产的融合蛋白及其应用 |
| EP4219564A1 (en) | 2014-09-12 | 2023-08-02 | The Board of Trustees of the Leland Stanford Junior University | Wnt signaling agonist molecules |
| CN106367517A (zh) * | 2016-09-28 | 2017-02-01 | 湖北工业大学 | 一种低密度脂蛋白受体相关蛋白5基因突变检测的试剂及应用 |
| CA3085785A1 (en) | 2017-12-19 | 2019-06-27 | Surrozen, Inc. | Anti-lrp5/6 antibodies and methods of use |
| CN117946267A (zh) | 2017-12-19 | 2024-04-30 | 瑟罗泽恩奥普瑞汀公司 | 抗卷曲蛋白抗体和使用方法 |
| AU2018393073B2 (en) | 2017-12-19 | 2025-09-18 | Surrozen Operating, Inc. | Wnt surrogate molecules and uses thereof |
| CN111632147A (zh) * | 2020-06-07 | 2020-09-08 | 重庆医科大学 | 骨细胞Wnt激活剂在制备骨折加速愈合、防治骨不连及不运动或失重骨丢失药物中的应用 |
| CN115309402B (zh) * | 2022-07-13 | 2023-10-24 | 国网江苏省电力有限公司信息通信分公司 | 一种可量化差异的异构执行程序集合构成方法及装置 |
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| US7713526B2 (en) * | 2001-05-01 | 2010-05-11 | The Regents Of The University Of California | Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas |
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| US8461155B2 (en) | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
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| EP2336177A1 (en) | 2004-08-04 | 2011-06-22 | Amgen, Inc | Antibodies to DKK-1 |
| US7838252B2 (en) | 2005-02-17 | 2010-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating a subject having an anthrax toxin mediated condition |
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- 2005-05-18 EP EP11184755.4A patent/EP2409732B1/en not_active Expired - Lifetime
- 2005-05-18 CA CA2771940A patent/CA2771940C/en not_active Expired - Lifetime
- 2005-05-18 CA CA2772029A patent/CA2772029C/en not_active Expired - Lifetime
- 2005-05-18 CA CA2772033A patent/CA2772033C/en not_active Expired - Lifetime
- 2005-05-18 CN CNA2005800243835A patent/CN101316627A/zh active Pending
- 2005-05-18 JP JP2007527363A patent/JP2008505190A/ja active Pending
- 2005-05-18 CA CA2567023A patent/CA2567023C/en not_active Expired - Lifetime
- 2005-05-18 EP EP05751764A patent/EP1758562B1/en not_active Expired - Lifetime
- 2005-05-18 EP EP16000780.3A patent/EP3150255A1/en not_active Withdrawn
-
2006
- 2006-11-13 IL IL179241A patent/IL179241A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| US20050196349A1 (en) | 2005-09-08 |
| CA2771940C (en) | 2016-01-12 |
| WO2005115354A3 (en) | 2007-09-13 |
| JP2008505190A (ja) | 2008-02-21 |
| CA2771940A1 (en) | 2005-12-08 |
| CA2772033C (en) | 2016-05-17 |
| EP1758562A2 (en) | 2007-03-07 |
| EP1758562B1 (en) | 2012-12-05 |
| CN101316627A (zh) | 2008-12-03 |
| IL179241A0 (en) | 2007-03-08 |
| EP1758562A4 (en) | 2009-07-22 |
| US8637506B2 (en) | 2014-01-28 |
| EP2409732A1 (en) | 2012-01-25 |
| CA2771951C (en) | 2014-07-08 |
| IL179241A (en) | 2016-04-21 |
| CA2772033A1 (en) | 2005-12-08 |
| CA2772029A1 (en) | 2005-12-08 |
| EP2409732B1 (en) | 2016-04-06 |
| CA2771941A1 (en) | 2005-12-08 |
| US20060198791A2 (en) | 2006-09-07 |
| CA2771951A1 (en) | 2005-12-08 |
| EP3150255A1 (en) | 2017-04-05 |
| CA2772029C (en) | 2016-05-17 |
| WO2005115354A2 (en) | 2005-12-08 |
| CA2567023A1 (en) | 2005-12-08 |
| CA2567023C (en) | 2012-07-03 |
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