CA2767039C - Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes - Google Patents

Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes Download PDF

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Publication number
CA2767039C
CA2767039C CA2767039A CA2767039A CA2767039C CA 2767039 C CA2767039 C CA 2767039C CA 2767039 A CA2767039 A CA 2767039A CA 2767039 A CA2767039 A CA 2767039A CA 2767039 C CA2767039 C CA 2767039C
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CA
Canada
Prior art keywords
oxalate
oxdc
particles
enzymes
spray
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2767039A
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English (en)
French (fr)
Other versions
CA2767039A1 (en
Inventor
Harmeet Sidhu
Qingshan Li
Aaron Blake Cowley
Carol-Gustaf Goelander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxthera Intellectual Property AB
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Oxthera Intellectual Property AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/497,275 external-priority patent/US8431122B2/en
Priority claimed from EP09164430.2A external-priority patent/EP2270138B1/en
Application filed by Oxthera Intellectual Property AB filed Critical Oxthera Intellectual Property AB
Priority to CA3012811A priority Critical patent/CA3012811A1/en
Publication of CA2767039A1 publication Critical patent/CA2767039A1/en
Application granted granted Critical
Publication of CA2767039C publication Critical patent/CA2767039C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/13Transferases (2.) transferring sulfur containing groups (2.8)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/04Drugs for disorders of the urinary system for urolithiasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2767039A 2009-07-02 2010-07-01 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes Expired - Fee Related CA2767039C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3012811A CA3012811A1 (en) 2009-07-02 2010-07-01 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/497,275 US8431122B2 (en) 2009-07-02 2009-07-02 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes
EP09164430.2A EP2270138B1 (en) 2009-07-02 2009-07-02 Purification and isolation of recombinant oxalate degrading enzymes
US12/497,275 2009-07-02
EP09164430.2 2009-07-02
PCT/EP2010/003864 WO2011000523A1 (en) 2009-07-02 2010-07-01 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3012811A Division CA3012811A1 (en) 2009-07-02 2010-07-01 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes

Publications (2)

Publication Number Publication Date
CA2767039A1 CA2767039A1 (en) 2011-01-06
CA2767039C true CA2767039C (en) 2018-09-04

Family

ID=43028177

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2767039A Expired - Fee Related CA2767039C (en) 2009-07-02 2010-07-01 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes
CA3012811A Abandoned CA3012811A1 (en) 2009-07-02 2010-07-01 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3012811A Abandoned CA3012811A1 (en) 2009-07-02 2010-07-01 Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes

Country Status (16)

Country Link
US (1) US20120189604A1 (enExample)
EP (1) EP2449098B1 (enExample)
JP (2) JP2012531186A (enExample)
CN (2) CN104805067A (enExample)
BR (1) BRPI1013956B8 (enExample)
CA (2) CA2767039C (enExample)
DK (1) DK2449098T3 (enExample)
ES (1) ES2617917T3 (enExample)
HK (1) HK1210805A1 (enExample)
HU (1) HUE030905T2 (enExample)
IL (1) IL216873A (enExample)
IN (1) IN2012DN00592A (enExample)
LT (1) LT2449098T (enExample)
PL (1) PL2449098T3 (enExample)
PT (1) PT2449098T (enExample)
WO (1) WO2011000523A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8431122B2 (en) 2009-07-02 2013-04-30 Oxthera Intellectual Property Ab Purification and isolation of recombinant oxalate degrading enzymes and spray-dried particles containing oxalate degrading enzymes
WO2014113648A1 (en) * 2013-01-18 2014-07-24 Allena Pharmaceuticals, Inc. Crystallized oxalate decarboxylase and methods of use
CN103540569A (zh) * 2013-06-05 2014-01-29 黄虹寓 结石酶及其制备方法
US11077238B2 (en) * 2013-06-07 2021-08-03 Allena Pharmaceuticals, Inc. Compositions, methods, and devices for dialysis
CN107254453B (zh) * 2014-12-22 2019-10-25 武汉康复得生物科技股份有限公司 一种在生理pH条件下有活力的草酸氧化酶及其应用
CN114903985A (zh) * 2021-02-10 2022-08-16 宁波倍益嘉生物科技有限公司 一种组合物及其在防治高草酸尿症方面的应用
CN116124853B (zh) * 2022-11-07 2024-01-16 东北农业大学 一种检测草酸的电化学生物传感器、制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8486389B2 (en) * 1997-05-23 2013-07-16 Oxthera, Inc. Compositions and methods for treating or preventing oxalate-related disease
US6929940B1 (en) * 2002-08-20 2005-08-16 University Of Florida Research Foundation, Inc. Polynucleotides encoding oxalate decarboxylase from Aspergillus niger and methods of use
AU2003274918A1 (en) * 2002-08-20 2004-03-11 University Of Florida Polynucleotide encoding oxalate decarboxylase from aspergillus niger and methods of use
AU2005339139A1 (en) * 2005-12-14 2007-06-21 Oxthera, Inc. Pharmaceutical compositions and methods for treating or preventing oxalate-related disease
JP5558002B2 (ja) 2005-12-16 2014-07-23 オクセラ インコーポレイテッド シュウ酸塩低減化のための組成物および方法
DK2046373T3 (da) * 2006-08-02 2013-05-27 Althea Technologies Inc Krystalliseret oxalatdecarboxylase og fremgangsmåder til anvendelse

Also Published As

Publication number Publication date
PL2449098T3 (pl) 2017-06-30
CN102597225B (zh) 2015-04-29
US20120189604A1 (en) 2012-07-26
BRPI1013956B8 (pt) 2021-05-25
EP2449098A1 (en) 2012-05-09
JP2012531186A (ja) 2012-12-10
ES2617917T3 (es) 2017-06-20
CA3012811A1 (en) 2011-01-06
CA2767039A1 (en) 2011-01-06
JP2016121138A (ja) 2016-07-07
HUE030905T2 (en) 2017-06-28
IN2012DN00592A (enExample) 2015-06-12
LT2449098T (lt) 2017-05-25
CN104805067A (zh) 2015-07-29
CN102597225A (zh) 2012-07-18
BRPI1013956B1 (pt) 2021-04-06
EP2449098B1 (en) 2016-12-07
IL216873A (en) 2017-07-31
DK2449098T3 (en) 2017-03-06
JP6220845B2 (ja) 2017-10-25
WO2011000523A1 (en) 2011-01-06
PT2449098T (pt) 2017-03-10
BRPI1013956A2 (pt) 2019-04-09
IL216873A0 (en) 2012-02-29
HK1210805A1 (en) 2016-05-06

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