CA2760941C - System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function - Google Patents
System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17556609P | 2009-05-05 | 2009-05-05 | |
| US61/175,566 | 2009-05-05 | ||
| US31055710P | 2010-03-04 | 2010-03-04 | |
| US61/310,557 | 2010-03-04 | ||
| US32378210P | 2010-04-13 | 2010-04-13 | |
| US61/323,782 | 2010-04-13 | ||
| PCT/US2010/033801 WO2010129725A1 (en) | 2009-05-05 | 2010-05-05 | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
Publications (2)
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|---|---|
| CA2760941A1 CA2760941A1 (en) | 2010-11-11 |
| CA2760941C true CA2760941C (en) | 2019-07-23 |
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| EP (1) | EP2427543A4 (de) |
| CA (1) | CA2760941C (de) |
| WO (1) | WO2010129725A1 (de) |
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| US8263375B2 (en) | 2002-12-20 | 2012-09-11 | Acea Biosciences | Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology |
| US7192752B2 (en) | 2002-12-20 | 2007-03-20 | Acea Biosciences | Real time electronic cell sensing systems and applications for cell-based assays |
| US11346797B2 (en) | 2002-12-20 | 2022-05-31 | Agilent Technologies, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties |
| US10539523B2 (en) | 2002-12-20 | 2020-01-21 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties |
| US9709548B2 (en) | 2008-05-05 | 2017-07-18 | Acea Biosciences, Inc. | Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution |
| US10215748B2 (en) | 2002-12-20 | 2019-02-26 | Acea Biosciences, Inc. | Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways |
| US10551371B2 (en) | 2003-11-10 | 2020-02-04 | Acea Biosciences, Inc. | System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function |
| WO2011146531A1 (en) | 2010-05-18 | 2011-11-24 | Acea Biosciences, Inc | Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (rtca) cardio instruments |
| WO2012178095A1 (en) * | 2011-06-22 | 2012-12-27 | Ifluidics, Inc. | Electromotive system for high-throughput screening |
| EP2929014A4 (de) | 2012-12-07 | 2016-08-03 | Univ Toronto | Herzgewebekonstrukte und verfahren zur herstellung davon |
| CN110582569B (zh) | 2017-03-03 | 2024-04-02 | 安捷伦科技有限公司 | 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统 |
| ES2933512T3 (es) * | 2017-08-16 | 2023-02-09 | Amgen Inc | Disposición de electrodos adaptable para su implementación en un sistema de incubación de células y sus aplicaciones |
| CN113655102A (zh) * | 2021-08-25 | 2021-11-16 | 深圳市溢鑫科技研发有限公司 | 一种电化学测量微电极结构及其制作方法 |
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| US5981268A (en) * | 1997-05-30 | 1999-11-09 | Board Of Trustees, Leland Stanford, Jr. University | Hybrid biosensors |
| JPH11187865A (ja) * | 1997-12-25 | 1999-07-13 | Matsushita Electric Ind Co Ltd | 細胞電位測定電極及びこれを用いた測定装置 |
| US8206903B2 (en) * | 2002-12-20 | 2012-06-26 | Acea Biosciences | Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses |
| AU2003267998A1 (en) * | 2002-07-20 | 2004-02-09 | Acea Biosciences, Inc. | Impedance based devices and methods for use in assays |
| GB0414546D0 (en) * | 2004-06-29 | 2004-08-04 | Oxford Biosensors Ltd | Electrode for electrochemical sensor |
| EP2213721B1 (de) * | 2007-09-18 | 2016-03-02 | Reprocell, Inc. | Zellmessgefäss, extrazelluläres potentialmessverfahren und chemisches testverfahren |
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- 2010-05-05 CA CA2760941A patent/CA2760941C/en active Active
- 2010-05-05 EP EP10772804.0A patent/EP2427543A4/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP2427543A4 (de) | 2017-11-29 |
| EP2427543A1 (de) | 2012-03-14 |
| CA2760941A1 (en) | 2010-11-11 |
| WO2010129725A1 (en) | 2010-11-11 |
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