CA2760941A1 - Systeme et procede destines a suivre le battement, la viabilite et la morphologie des cardiomyocytes et a cribler des molecules a la recherche d'agents pharmacologiques qui peuven t induire une cardiotoxicite ou moduler la fonction des cardiomyocytes - Google Patents

Systeme et procede destines a suivre le battement, la viabilite et la morphologie des cardiomyocytes et a cribler des molecules a la recherche d'agents pharmacologiques qui peuven t induire une cardiotoxicite ou moduler la fonction des cardiomyocytes Download PDF

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Publication number
CA2760941A1
CA2760941A1 CA2760941A CA2760941A CA2760941A1 CA 2760941 A1 CA2760941 A1 CA 2760941A1 CA 2760941 A CA2760941 A CA 2760941A CA 2760941 A CA2760941 A CA 2760941A CA 2760941 A1 CA2760941 A1 CA 2760941A1
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CA
Canada
Prior art keywords
electrode
impedance
cells
cell
recording
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2760941A
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English (en)
Other versions
CA2760941C (fr
Inventor
Xiaobo Wang
Wei Ouyang
Nan Li
Biao Xi
Yama A. Abassi
Xiao Xu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
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Acea Biosciences Inc
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Publication of CA2760941A1 publication Critical patent/CA2760941A1/fr
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
CA2760941A 2009-05-05 2010-05-05 Systeme et procede destines a suivre le battement, la viabilite et la morphologie des cardiomyocytes et a cribler des molecules a la recherche d'agents pharmacologiques qui peuven t induire une cardiotoxicite ou moduler la fonction des cardiomyocytes Active CA2760941C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17556609P 2009-05-05 2009-05-05
US61/175,566 2009-05-05
US31055710P 2010-03-04 2010-03-04
US61/310,557 2010-03-04
US32378210P 2010-04-13 2010-04-13
US61/323,782 2010-04-13
PCT/US2010/033801 WO2010129725A1 (fr) 2009-05-05 2010-05-05 Système et procédé destinés à suivre le battement, la viabilité et la morphologie des cardiomyocytes et à cribler des molécules à la recherche d'agents pharmacologiques qui peuvent induire une cardiotoxicité ou moduler la fonction des cardiomyocytes

Publications (2)

Publication Number Publication Date
CA2760941A1 true CA2760941A1 (fr) 2010-11-11
CA2760941C CA2760941C (fr) 2019-07-23

Family

ID=43050454

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2760941A Active CA2760941C (fr) 2009-05-05 2010-05-05 Systeme et procede destines a suivre le battement, la viabilite et la morphologie des cardiomyocytes et a cribler des molecules a la recherche d'agents pharmacologiques qui peuven t induire une cardiotoxicite ou moduler la fonction des cardiomyocytes

Country Status (3)

Country Link
EP (1) EP2427543A4 (fr)
CA (1) CA2760941C (fr)
WO (1) WO2010129725A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
WO2005047482A2 (fr) 2003-11-12 2005-05-26 Xiao Xu Systemes de detection de cellules electroniques en temps reel pour des epreuves a base de cellules
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
EP2291645B1 (fr) 2008-05-05 2015-09-09 Acea Biosciences, Inc. Surveillance sans marqueur d'un couplage excitation-contraction et cellules pouvant être excitées utilisant des systèmes fondés sur l'impédance avec une résolution dans le temps de l'ordre de la milliseconde
WO2011146531A1 (fr) 2010-05-18 2011-11-24 Acea Biosciences, Inc Analyse de données de signaux de battements de cardiomyocytes à base d'impédance tels que détectés sur des instruments cardiologiques d'analyse de cellules en temps réel (rtca)
WO2012178095A1 (fr) * 2011-06-22 2012-12-27 Ifluidics, Inc. Système électromoteur pour le criblage à haut débit
US10034738B2 (en) 2012-12-07 2018-07-31 The Governing Council Of The University Of Toronto Cardiac tissue constructs and methods of fabrication thereof
CN110582569B (zh) 2017-03-03 2024-04-02 安捷伦科技有限公司 用于iPSC和ESC衍生的心肌细胞的功能成熟的方法和系统
CA3070474A1 (fr) * 2017-08-16 2019-02-21 Amgen Inc. Agencement adaptatif d'electrodes destine a etre mis en ƒuvre dans un systeme d'incubateur de cellules et applications correspondantes
CN113655102A (zh) * 2021-08-25 2021-11-16 深圳市溢鑫科技研发有限公司 一种电化学测量微电极结构及其制作方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981268A (en) * 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
JPH11187865A (ja) * 1997-12-25 1999-07-13 Matsushita Electric Ind Co Ltd 細胞電位測定電極及びこれを用いた測定装置
CN100487133C (zh) * 2002-07-20 2009-05-13 艾森生物(杭州)有限公司 基于阻抗的检测装置和方法
US8206903B2 (en) * 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
GB0414546D0 (en) * 2004-06-29 2004-08-04 Oxford Biosensors Ltd Electrode for electrochemical sensor
US8702922B2 (en) * 2007-09-18 2014-04-22 Reprocell, Inc. Cell measuring vessel, extracellular potential measuring method, and chemical testing method

Also Published As

Publication number Publication date
EP2427543A1 (fr) 2012-03-14
EP2427543A4 (fr) 2017-11-29
CA2760941C (fr) 2019-07-23
WO2010129725A1 (fr) 2010-11-11

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Effective date: 20150501