CA2758855A1 - Compounds for the treatment of mitochondrial diseases - Google Patents

Compounds for the treatment of mitochondrial diseases Download PDF

Info

Publication number
CA2758855A1
CA2758855A1 CA2758855A CA2758855A CA2758855A1 CA 2758855 A1 CA2758855 A1 CA 2758855A1 CA 2758855 A CA2758855 A CA 2758855A CA 2758855 A CA2758855 A CA 2758855A CA 2758855 A1 CA2758855 A1 CA 2758855A1
Authority
CA
Canada
Prior art keywords
carbon atoms
compounds
atom
formula
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2758855A
Other languages
English (en)
French (fr)
Inventor
Marc Blondel
Elodie Couplan
Jean-Paul Di Rago
Daniel Dauzonne
Michael Palladino
Alicia Celotto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Institut Curie
University of Pittsburgh
Original Assignee
Centre National de la Recherche Scientifique CNRS
Institut Curie
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS, Institut Curie, University of Pittsburgh filed Critical Centre National de la Recherche Scientifique CNRS
Publication of CA2758855A1 publication Critical patent/CA2758855A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4425—Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/40—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24—Y being a hetero atom
    • C07C279/26—X and Y being nitrogen atoms, i.e. biguanides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Tents Or Canopies (AREA)
  • Pyrane Compounds (AREA)
CA2758855A 2009-04-17 2010-04-15 Compounds for the treatment of mitochondrial diseases Abandoned CA2758855A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09290288.1 2009-04-17
EP09290288A EP2243476A1 (en) 2009-04-17 2009-04-17 Compounds for the treatment of mitochondrial diseases
PCT/IB2010/001006 WO2010119344A1 (en) 2009-04-17 2010-04-15 Compounds for the treatment of mitochondrial diseases

Publications (1)

Publication Number Publication Date
CA2758855A1 true CA2758855A1 (en) 2010-10-21

Family

ID=40972893

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2758855A Abandoned CA2758855A1 (en) 2009-04-17 2010-04-15 Compounds for the treatment of mitochondrial diseases

Country Status (5)

Country Link
US (2) US20120329834A1 (enExample)
EP (2) EP2243476A1 (enExample)
JP (1) JP2012524059A (enExample)
CA (1) CA2758855A1 (enExample)
WO (1) WO2010119344A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011088113A1 (en) * 2010-01-12 2011-07-21 Cabreeco Companies Llc Movable enclosure
US20110308173A1 (en) * 2009-09-04 2011-12-22 Forsland Kent H Movable building structure
WO2014082129A1 (en) * 2012-11-28 2014-06-05 Expanding Buildings Pty Ltd Transportable and expandable building structure
CA2849567C (en) * 2013-04-18 2016-05-24 James Bert Farmer Portable building
US9549942B2 (en) * 2013-07-15 2017-01-24 Research & Business Foundation Sungkyunkwan University Composition for preventing or treating degenerative brain diseases including compound downregulating expression of BACE1 proteins
FR3029113A1 (fr) 2014-12-02 2016-06-03 Univ Paris-Sud Composes pour le traitement des maladies mitochondriales
JP6404395B1 (ja) * 2017-03-31 2018-10-10 Ｊｓｃ株式会社 アリーナ及びアリーナの施工方法
CN118923413B (zh) * 2024-08-12 2025-05-30 中科绿控科技有限公司 一种蔬菜种植用的智能防虫设备

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL45585C (enExample) 1936-05-28 1900-01-01
US2170111A (en) 1936-05-28 1939-08-22 Rohm & Haas Manufacture of amines
US2229024A (en) 1939-05-23 1941-01-21 Rohm & Haas Aromatic ether of polyalkoxyalkylalkylene polyamines and process for obtaining them
US2684924A (en) 1951-02-05 1954-07-27 Ici Ltd Nu-chlorophenyldiguanidino compounds
US2745826A (en) 1953-12-16 1956-05-15 Olin Mathieson Process of preparing thiourea complexes
US3766691A (en) * 1971-12-02 1973-10-23 G Ray Convertible pool enclosure
US4280306A (en) * 1979-06-04 1981-07-28 Vojin Milinic Convertible enclosure for buildings and areas
US4478268B1 (en) * 1980-12-29 1991-04-23 Door structure
CA1260025A (en) * 1985-11-14 1989-09-26 M & I Door Systems Limited Apparatus for opening and closing industrial door
US4974658A (en) * 1989-02-22 1990-12-04 Komatsu Denki Sangyo Kabushiki Kaisha Sheet shutter
US5038517A (en) * 1989-05-19 1991-08-13 Talbott Gene B Greenhouse construction
US5484007A (en) * 1990-05-11 1996-01-16 Rejc; Gabrijel Vertical lift gate with strip cladding in guideways
DE4015216A1 (de) * 1990-05-11 1991-11-14 Efaflex Transport Lager Abschlusselement fuer eine oeffnung
US4984399A (en) * 1990-06-25 1991-01-15 Taylor Gary L Automobile enclosure
US5139074A (en) * 1991-04-03 1992-08-18 Kelley Company Inc. Industrial door having flexible and releasable beam
US5123474A (en) * 1991-05-13 1992-06-23 Smith Richard C Roll-up closure device
US5392836A (en) * 1992-06-23 1995-02-28 Rite Hite Corporation Door assembly
FR2714828B1 (fr) * 1994-01-12 1996-02-02 Rhone Poulenc Rorer Sa Application du riluzole dans le traitement des maladies mitochondriales.
US5601134A (en) * 1995-03-23 1997-02-11 Rite-Hite Corporation Retainer assembly for roll-up door
US5765622A (en) * 1996-11-08 1998-06-16 Thruways Doorsystems Inc. Vertically moveable flexible door with releasable bottom bar
BR9811549A (pt) * 1997-07-25 2000-11-28 Rytec Corp Porta suspensa de enrolar para aplicações sanitárias
US6098698A (en) * 1998-12-11 2000-08-08 King-Darr; Carol L. Garage door opening screen enclosure
SE9903760D0 (sv) * 1999-10-18 1999-10-18 Astra Ab New compounds
US6296039B1 (en) * 2000-03-08 2001-10-02 Wayne-Dalton Corporation Apparatus and method for windlocking a building opening
JP2004182705A (ja) * 2002-10-11 2004-07-02 Yasutoshi Koga ミトコンドリア機能異常に起因する疾患における臨床症状発現の予防・治療用組成物
US7240715B2 (en) * 2003-12-24 2007-07-10 Hunter Douglas Inc. Limit stop for coverings for architectural openings
US20070037800A1 (en) * 2005-06-23 2007-02-15 Envivo Pharmaceuticals, Inc. Method of treating neurological disorders using clotrimazole and derivatives thereof
US20070208086A1 (en) * 2006-02-15 2007-09-06 The Regents Of The University Of California Ubiquinone analogs and methods of use
FR2900660B1 (fr) 2006-05-03 2008-07-11 Univ Victor Segalen Bordeaux 2 Modelisation chez la levure des mutations du gene mitochondrial atp6 responsables du syndrome narp chez l'homme et ses applications pour le criblage de medicaments

Also Published As

Publication number Publication date
EP2419094B1 (en) 2016-06-08
US20120329834A1 (en) 2012-12-27
JP2012524059A (ja) 2012-10-11
WO2010119344A1 (en) 2010-10-21
US20120090250A1 (en) 2012-04-19
EP2419094A1 (en) 2012-02-22
EP2243476A1 (en) 2010-10-27

Similar Documents

Publication Publication Date Title
EP2419094B1 (en) Compounds for the treatment of mitochondrial diseases
US20190247359A1 (en) Utility of (+) epicatechin and their analogs
US11104651B2 (en) PERK inhibitors and uses thereof in treating diseases associated with aggregation-prone proteins
EP3643311B1 (en) 4-oxo-alkylated tetramic acid compound, preparation method therefor and use thereof
JP2017535569A (ja) イブジラスト及びリルゾールの併用及びその使用法
EP3647306B1 (en) 4-oxo-alkylated tetramic acid compound and preparation method therefor
CN114478450A (zh) 苄氧基苯酞类化合物、其制备方法和用途
CN108101780A (zh) 一类氟比洛芬查尔酮类化合物、其制备方法和用途
US20100273769A1 (en) Composition and method for the treatment of parkinson's disease
TW202116299A (zh) 雙肽重複蛋白之抑制
AU2021313398A1 (en) Use of Alverine or its derivatives for the treatment of mitochondrial diseases or dysfunction associated with mitochondrial complex I deficiencies
JP2021520413A (ja) 眼科的状態のための療法
CN110003034B (zh) 一类羟基氟比洛芬曼尼希碱类化合物、其制备方法和用途
CN109912448B (zh) 一类苄胺基氟比洛芬酰胺类化合物、其制备方法和用途
CN109912443B (zh) 一类苄胺基氟比洛芬类化合物、其制备方法和用途
ITRM960180A1 (it) Bis alcanoil esteri della carnitina ad attivita' antibatterica, anti= micotica ed antiprotozoaria.
JP2005330265A (ja) 新規化合物及びその医薬用途
CN119192289B (zh) 具有清除Aβ1-42蛋白沉积的高抗氧化活性改善学习记忆力核桃衍生肽及其应用
US7074938B2 (en) Method for the synthesis of soritin compounds
ES2749695T3 (es) Compuestos para el tratamiento de las enfermedades mitocondriales
AU2023302582A1 (en) Use of ebselen or one of the derivatives thereof to treat mitochondrial pathologies or dysfunctions
CN117903092A (zh) 二羟基苯酞类化合物及其制备方法和用途
CN119735529A (zh) 一种苯甲酰苯胺类化合物及在制备铜绿假单胞菌抑制剂的增敏剂中的应用
CN117659024A (zh) 一种酰胺取代的色胺酮类衍生物及其制备方法和应用
CN118108654A (zh) 一种取代靛红-阿魏酸酯衍生物及其制备方法和应用

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150317

FZDE Discontinued

Effective date: 20170918