CA2749174A1 - Benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses - Google Patents

Benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses Download PDF

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CA2749174A1
CA2749174A1 CA2749174A CA2749174A CA2749174A1 CA 2749174 A1 CA2749174 A1 CA 2749174A1 CA 2749174 A CA2749174 A CA 2749174A CA 2749174 A CA2749174 A CA 2749174A CA 2749174 A1 CA2749174 A1 CA 2749174A1
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benzimidazole
amide
pyrimidinyl
pyridyl
methyl
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CA2749174C (en
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Xianjin Luo
Fei Xue
Zhonglv Zhang
Naiyun Xiu
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Zhejiang Medicine Co Ltd Xinchang Pharmaceutical Factory
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Shanghai Jiaotong University
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D487/04—Ortho-condensed systems

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Abstract

The present invention relates to the benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses; wherein X
represents monosubstituted or bissubstituted or polysubstitued C1-C14 alkoxy, monosubstituted or bisubstituted or polysubstitued C1-C14 alkyl, monosubstituted or bisubstituted or polysubstitued C2-C14 alkenyl, monosubstituted or bisubstituted or polysubstitued C6-C14 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom; Y represents hydrogen, monosubstituted or bisubstituted or polysubstitued C1-C16 alkyl, monosubstituted or bisubstituted or polysubstitued C6-C12 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom. The derivatives of the present invention have the functions of antiviral medicine.

(see figure I)

Description

SPECIFICATION
BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION
METHODS, PHARMACEUTICAL COMPOSITIONS AND THEIR USES

FIELD OF THE INVENTION

The present invention relates to benzimidazole carboxamide derivatives, in particular, relates to the benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses BACKGROUND OF THE INVENTION

The diseases caused by virus infections severely threaten human health and life and have become major problems in the medical fields. Almost 70% of epidemic diseases are caused by viruses infections statistically. The infectious diseases caused by enteroviruses have often occurred all over the world. The enteroviruses belong to picornaviridae comprising polio viruses, cosxackie viruses, enteric cytopathogenic human orphan virus and new enteroviruses. Each viruses has many serums, at least more than 70 types, which can violate many kinds of tissues, such as nerves, cardiac muscles, muscles, skins and eye conjunctiva etc and can cause lots of infectious diseases all over the world.
There are lots of categories of the cosxackie viruses, whose transmission route and pathogenesis are similar to that of poliomyelitis virus, and often occurrs latent infections. Their symptom shows slight upper respiratory infections or diarrhea, and occasionally inflects central nervous systems, damages spinal cord anterior horn motor neurons, and causes flaccid paralysis of limbs, however, this symptom is relatively light. The cosxackie viruses can violate many tissues and systems, such as respiratory tracts, intestinal tracts, skins, muscles, hearts, livers, adrenal gland and central nervous systems, Clinical manifestations have various of symptoms such as (l)respiratory tract infection, (2) herpangina, (3) febrile rush, (4) hand-foot-and-mouth disease, (5) diarrhea of children, (6) central nervous system syndrome, (7) myocarditis and pericarditis, (8) epidemic chest pain or epidemic myalgia, (9) epidemic conjunctivitis, (10) coxsackie virus hepatitis and so on.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide benzimidazole-4-carboxamide derivatives having anti-coxsackie virusesor a pharmaceutically acceptable salts thereof as shown in Formula (1) .

Y
I
N-H

~ N\

(I) Wherein, X represents monosubstituted or bissubstituted or polysubstitued C1-alkoxy, monosubstituted or bisubstituted or polysubstitued C1-C14 alkyl, monosubstituted or bisubstituted or polysubstitued C2-C14 alkenyl, monosubstituted or bisubstituted or polysubstitued C6-C14 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom.

Y represents hydrogen, monosubstituted or bisubstituted or polysubstitued C1-alkyl, monosubstituted or bisubstituted or polysubstitued C6-C12 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom.
Wherein: X is selected from one of the following groups:

-fgnC-R5 R2' R1' I I
-O-R Ry R4 R3'-C=C- R13 R12 R2d R19 8117. R"17 R1118 R'24 R29 N N
-J-R18 N R23 N R'23 N N~ N
R'2 Rig R"2 R"19 R R25 R25 R3~R30 Ras N R43 R39 = 44 +45 R -) Ras R42NXRoo R-46 I I J~
Rs N Rm1 N R'm1 _ -~ -Rs1 Rm2 R'm2 N
S~ Rs2 2 Rm3 Rm3 , , , , N Rk2 Rk3 Rk4 Rk2 Rk3 F`' Rk~ RPi - i i R'm2 R'm 1 I I N RP2 N N / Rk, Rk, N Rks R'm3 Rk6 Rk6 Rp4 RP3 RYi NH Rmz N Rbz1~ N, N

Ry F_" N Rbz RY3 RY4 Rmzj or Rbz3 Rwy1 RwY3 )n- Rwy5 wherein R is selected from -H,or R\"Y2 Rwy4 wherein n is selected from 0 to 5, R,,,y1, Rwy2, Rõy3, R,,,y4 and R,,,y5 are respectively and independently selected from -H, -CH3, or -CH2CH3;

n=0-5; R1, R2, R3, R4 and R5 are respectively and independently selected from -H, -CH3, -F, -Cl, -Br, -l, -OH, -OCH3, -OCHZCH3, -NO2, -NH-CH3, -NH-CH2CH3, CH3-N-CH,CH2OH
-NH-CH2CH2OH, C H 3-N -C H, C H 3-N -C H 2C H 3 , CHIC H,-N-CHC HJ , CH3CH,-N-CH,CH,OH OHCH5CHN-CH2CHOH or phenyl substituted by one or several substituents Ra, Ra is selected from -F, -Cl, -Br, -1, -CH3, -CH2CH3, -OH, -OCH3, -OCH2CH3, -CH2CH2OH, -NO2, -NH2, -N(CH3 )2, -N(CH2CH3 )2, -N(CH2CH2OH )2, -CN, -000H, -COOCH3, -COOCH2CH3, or -COOC6H5;
RI', R2' and R3' are respectively and independently selected from -H, -CH3, -CH2CH3, R

CH (CH2)n 3 R"
or 2 , wherein n is an integer between 0 and 5; RI" and R2" are respectively and independently selected from -H, -CH3, or -CH2CH3;

R9, R10, R11, R12 and R13 are respectively and independently selected from -H, -CH3, -CH2CH3, -COOH , -COOCH3, -COOCH2CH3, -OH, -OCH3, -OCH2CH3, -CN, -F, -Cl, -Br, -1, or -NH2, -N(CH3)2, or -N(CHZCH3)2;
RP, R18, Rig, R20, R'17, R'18, R'19, R' R" R"18, R"19 and R"20 are respectively 17, 18, 19, 20, 17, 18, 20, 17, 18, 19 and independently selected from -H, -CH3, -CH2CH3, -OH, -OCH3, -OCH2CH3, -CF3, -CC139 -CBr3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -NO or -NO2, which cannot represent H simultaneously;

R23, R24, R25, R'23, R'24 and R'25 are respectively and independently selected from -H, -CH3, -CH2CH3, -F, -Cl, -Br, -1, -OH, -OCH3, -OCH2CH3, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -COON, -COOCH3, or -COOCH2CH3;

R29, R30 and R31 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2i R34, R36 and R41 are respectively and independently selected from -H, -(CH2)"CH3, -CH2OH, -CH2CH2OH, -CH(CH3)2 or -CH2CH(OH)CH3, n is an integer between 0 and 5;
R35, R37, R38, R39, R40, R42 and R43 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH,OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH-OH, or -N(CH2CH2OH)2i Z is selected from N, 0 or S.

R44, R45, R46, R'44, R'45 and R'46 are respectively and independently selected from -H, -CH3, -CH2CH3, -OH, -OCH3, -OCH2CH3, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -CN or -000H, -COOCH3, or -COOCH2CH3;

Rs1, Rs2, R S1 and R s2 are respectively and independently selected from -H, -CH3, -CH2CH3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -F, -Cl, -Br, -I, or NHCOCH3, NHCOCH2CH3, or NHCOC6H5;

Rml, Rm2, Rm3, R m1, Riii2 and R,,,3 are respectively and independently selected from -H, -CH3, -CH2CH3, -F, -Cl, -Br, -I, -OH, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -No NH- CN
-N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, Rm'-N N-'\ 1' or -NHC6H5;

Rk1, Rk2, Rk3, Rk4, Rks and Rk6 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH7CH2OH)2;

RPI, RP7 , RP3 and RP4 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 YI -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2i Ry1, Rye, Rya fn Ry.4 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2i RmzI is selected from -H, -CH3. -CH2CH3, -CH2CH2OH, -C6H5, or -CH2C6H5; Rmz2 and Rmz3 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CHZOH)2;

Rbzl is selected from -H, -CH3, -CH2CH3, -CH2CH2OH, -C6H5, or -CH2C6H5; Rbz2 and Rbz3 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2;
Y is selected from one group of the following groups:

--R51 --CQ-R-57 --CQ-~-R64 - - - -R73 I - I i l i -CH3, R52 R54 R56 R59 R61 R63 R66 R68 Rip R72 R'85 Ra? Rs7 FIX N

RE RE N R'86 R'87 Ra9 R68 R89 Ry4 R' R$$ ~ ~ 96 Q R' 90 --~S R96 R96 Q

R'4+ Rm1 N R'm1 -Rm2 R'rn2 7 R:
4n2~~ Rm 1 R' &5 N
95 Rrn3 Rm3 Rm3 Rb4 Rb3 Rb Rb O N N N
~ Rmz3 Rbz IN I I I
N~ N/' Rmz RPiI Rp13 Rbj Rb, Rmzl Rp12 or Rpl 1 N N
NK
I RP's Rp12 wherein, R50, R51, R52, R53, R54, R55, R56, R57, R58, R59, Rho, R61, R62, R63, R64, R65, R66, R67, R68, R69, R7o, R71, R72 and R73 are respectively and independently selected from -H, -CH31 -CH7CH3, -CH2OH, -OH, -OCH3, -OCH2CH3, -CN, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH,CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -F, -Cl, -Br, -1, or -C6H5, -C6H4-CH3, -C6H4-OH. -C6H4-NO2, or -C6H4-NH2;

R77, R78, R79, R80 and R81 are respectively and independently selected from -H, -CH3, -CH2CH3, -OH, -OCH3, -OCH2CH3. -NO2, -CN, -COOH, -COOCH3, -COOCH2CH3, -F, -Cl, -Br, -1, -CF3. -CCI3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH,CH-,OH, or -N(CH2CH2OH)2;

R85, R86 and R87 are respectively and independently selected from -H, -CH3, -CH2CH3, -OH or -NH2; R'85, R'86 and R'87 are respectively and independently selected from -H, -CH3, -CH2CH3, -C6H5, or -CH2C6H4;

Q is selected from N, 0 or S;

R88, R89, Rgo, R' 88, R' 89 and R' 90 are respectively and independently selected from -H, -CH2CH3, -OH, -OCH3,-OCH2CH3, -NO2, -NH2,-NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -CN, -COOH, -COOCH3, or -COOCH2CH3;

R94, R95, R' 94 and R' 95 are respectively and independently selected from -H, -CH3, -CH2CH3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -F, -Cl, -Br, -I, or -NHCOCH3, NHCOCH2CH3, or NHCOC6H5;

R96 is selected from -H, -CH3, -CH2CH3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2; R'96 is selected from -H, -CH3, -CH2CH3, -C6H5, or -CH2C6H4;
Rmi, Rm2, Rm3, R m1, R,,,2 and R',,,3 are respectively and independently selected from -H, -CH3, -CH2CH3, -F, -Cl, -Br, -1, -OH, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCHZCHZOH, -N(CH2CH2OH)2, or -NHC6H5;

Rbl, Rb2, Rb3 and Rb4 are respectively and independently selected from -H, -CH3, -CH2CH3, -CH7OH, -OH, -OCH3_ -OCH2CH3, -CN, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CHZOH, -N(CH2CH2OH)2, -F, -Cl, -Br, or -I;

Rmzi is selected from -H, -CH3, -CH2CH3, -CH2CH2OH, -C6H5, or -CH2C6H5; Rmz2 and R, are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -CONH2, or -COOH;

Rpi1 and Rp12 are respectively and independently selected from -H, -CH3, -CH2CH3, -OH, -OCH3, -OCH2CH3, F, Cl, Br, or 1; Rp13 is selected from -H, -CH3, -CH2CH3, CH2CH2OH, -C6H5, or -CHZC6H5.

Preferably, X represents monosubstituted or polysubstitued or unsubstituted alkoxy, monosubstituted or polysubstitued or unsubstituted alkyl, monosubstituted or polysubstituted or unsubstituted alkenyl, monosubstituted or bisubstituted or unsubstituted thienyl, monosubstituted or bisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstituted pyridazinyl, monosubstituted or bisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or unsubstituted pyrazinyl, monosubstituted or bisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted phenyl, monosubstituted or bisubstituted or unsubstituted pyrimidinyl, monosubstituted or bisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or unsubstituted quinolinyl, monosubstituted or bisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or unsubstituted indolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrazolyl.

More preferably, X represents C 1-C6 alkyloxy substituted by nitro, amino, hydroxyl or aryl; , C1-C6 alkyl substituted by nitro, amino, hydroxyl or aryl; C2-C14 alkenyl substituted by alkyl, hydroxyl or aryl; thienyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted thienyl; pyidyl monosubstituted by nitro, amino or C1-C6 alkyl;
unsubstituted pyridyl; quinolinyl monosubstituted by nitro, amino or C1-C6 alkyl;
unsubstituted quinolinyl; indolyl monosubstituted by nitro, amino or CI-C6 alkyl;
unsubstituted indolyl; pyridyl monosubstituted or bisubstituted by CI-C6 alkoxy; pyridyl monosubstituted or bisubstituted by CI-C3 dialkylamino; pyridyl monosubstituted or bisubstituted by C1-C6 alkyl; unsubstituted pyridyl; pyridazinyl monosubstituted by C1-C6 alkoxy; pyridazinyl monosubstituted by CI-C6 alkyl; unsubstituted pyridazinyl;
unsubstituted piperazinyl; piperazinyl bisubstituted by C1-C6 alkyl;
unsubstituted piperidinyl; unsubstituted pyrazinyl; unsubstituted thiazolyl; imidazolyl monosubstituted by nitro, amino or CI-C6 alkyl; unsubstituted imidazolyl; thiazolyl bisubstituted by CI-C6 alkyl and nitro; unsubstituted pyrimidinyl; pyrimidinyl monosubstituted by phenyl;
pyrimidinyl bisubstituted by amino and a group selected from nitro, -F, -Cl, -Br or -I;
phenyl trisubstituted by trihydroxyl; phenyl trisubstituted by trimethoxyl;
phenyl bisubstituted by hydroxyl and methoxyl; imidazolyl substituted by a group selected from methyl, ethyl, carboxyl or amido; pyrazolyl bisubstituted or trisubstituted by a group selected from C 1-C6 alkyl or aryl and a group selected from -F, -Cl, -Br or -I.

Preferably, Y represents hydroxyl, C1-C6 alkyl, monosubstituted or bisubstituted or trisubstituted phenyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstitued pyrazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzpyrimidinyl, monosubstituted or bisubstituted or trisubstituted or tetrasubstituted or unsubstituted benzimidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzimidazolonyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted purinyl.

More preferably, Y represents hydroxymethyl, hydroxyethyl, aminophenyl, hydroxyphenyl, C1-C6 alkylphenyl, phenyl monosubstituted by -F, -Cl, -Br or -1, phenyl bisubstituted by hydroxyl and carboxyl, hydroxyethyl bisubstituted by hydroxylmethyl or C1-C6 alkyl and monosubstituted phenyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, pyridyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, pyrazinyl monosubstituted or bisubstituted or unsubstituted, by C1-C6 alkyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, pyrrolyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, thiazolyl monosubstituted by C1-C6 alkyl, pyrimidinyl monosubstituted or bisubstituted or unsubstituted by C1-C6 alkyl, pyrimidinyl monsubstituted by C,-C6 alkyl and bisubstituted by hydroxyl, pyrimidinyl monosubstituted CI-C6 alkyl and bisubstituted or trisubstituted by -F, -Cl, -Br or -I, purinyl monosubstituted or bisubstituted or unsubstituted by CI-C6 alkyl, purinyl monosubstituted by CI-C6 alky and substituted or trisuvstituted by hydroxyl.

Most preferably , the benzimidazole-4-carboxamide derivatives as shown in Formula (1) includes the following compounds:

(1)(L)-2-(5-nitro-2-thienyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide (2)(L)-2-(5-am ino-2-thienyl)-1 H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide (3)(L)-2-(5-amino-2-thienyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (4)2-(5-amino-2-thienyl)-1 H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenylhydroxy ethyl)]amide (5)2-(5-amino-2-thienyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide (6)2-(5-amino-2-thienyl)-1 H-benzimidazole-4-(N-o-chlorophenyl)amide (7)2-(5-amino-2-thienyl)-1 H-benzimidazole-4-(N-o-bromophenyl)amide (8)2-(5-amino-2-thienyl)-1 H-benzimidazole-4-(N-m-fluorophenyl)amide (9)2-(5-amino-2-thienyl)-l H-benzimidazole-4-(N-m-chlorophenyl)amide (10)2-(5-amino-2-thienyl)-I H-benzimidazole-4-(N-m-bromophenyl)amide (11)2-(5-amino-2-thienyl)-I H-benzimidazole-4-(N-p-fluorophenyl)amide (12)2-(5-amino-2-thienyl)-I H-benzimidazole-4-(N-p-chlorophenyl)amide (13)2-(5-amino-2-thienyl)-I H-benzimidazole-4-(N-p-bromophenyl)amide (14)2-(5-amino-2-thienyl)-l H-benzimidazole-4-(N-o-methylphenyl)amide (15)2-(5-amino-2-thienyl)-1 H-benzimidazole-4-(N-o-hydroxylphenyl)amide (16)2-(5-amino-2-thienyl)-1 H-benzimidazole-4-(N-o-aminophenyl)am ide (17)2-(5-amino-2-th ienyl)-I H-benzim idazole-4-(N-m-methylphenyl)amide (18)2-(5-amino-2-thienyl)-I H-benzimidazole-4-(N-m-hydroxylphenyl)amide (19)2-(5-amino-2-thienyl)-1 H-benzim idazole-4-(N-m-aminophenyl)am ide (20)2-(5-am ino-2-thienyl)-I H-benzim idazole-4-(N-p-methylphenyl)amide (21 )2-(5 -amino-2-thienyl)-I H-benzim i dazole-4-(N-p-hydroxylphenyl)am ide (22)2-(5-amino-2-thienyl)- I H-benzimidazole-4-(N-p-aminophenyl)amide (23)(L)-2-(4-methoxypyridyl)- I H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylh ydroxyethyl)]amide (24)(L)-2-(4-methoxypyridyl)- I H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (25)2-(4-methoxypyridyl)- I H-benzim idazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyeth yl)]amide (26)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide (27)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-o-chorophenyl)amide (28)2-(4-methoxypyridyl)- I H-benzimidazole-4-(N-o-bromophenyl)amide (29)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-m-fluorophenyl)am ide (30)2-(4-methoxypyridyl)- I H-benzimidazole-4-(N-p-fluorophenyl)amide (31)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (32)2-(4-methoxypyridyl)- I H-benzimidazole-4-(N-o-aminophenyl)amide (33)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (34)2-(4-methoxypyridyl)-l H-benzimidazole-4-(N-m-aminophenyl)amide (35)2-(4-methoxypyridyl)-1 H-benzim idazole-4-(N-p-hydroxyphenyl)amide (36)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-p-aminophenyl)amide (37)(L)-2-(6-methoxypyridyl)-1 H-benzimidazole-4-[N-(I-hydroxymethyl-2-p-nitrophenylh ydroxyethyl)]am ide (38)(L)-2-(6-methoxypyridyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (39)2-(6-methoxypyridyl)-1 H-benzim idazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyeth yl)]amide (40)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide (41)2-(6-methoxypyridyl)-l H-benzimidazole-4-(N-m-fluorophenyl)amide (42)2-(6-methoxypyridyl)- I H-benzimidazole-4-(N-p-fluorophenyl)amide (43)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (44)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide (45)2-(6-methoxypyridyl)-1 H-benzim idazole-4-(N-m-hydroxyphenyl)am ide (46)2-(6-methoxypyridyl)- I H-benzimidazole-4-(N-m-aminophenyl)amide (47)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-p-hydroxyphenyl)amide (48)2-(6-methoxypyridyl)-l H-benzimidazole-4-(N-p-aminophenyl)amide (49)(L)-2-(4-dimethylaminopyridyl)- I H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]am ide (50)(L)-2-(4-dimethylaminopyridyl)- I H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-amino phenylhydroxyethyl)]am ide (51)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenylhydro xyethyl)]amide (52)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide (53)2-(4-dimethylaminopyridyl)- I H-benzimidazole-4-(N-m-fluorophenyl)amide (54)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-p-fluorophenyl)amide (55)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (56)2-(4-dimethylaminopyridyl)- I H-benzimidazole-4-(N-o-aminophenyl)amide (57)2-(4-dimethylam inopyridyl)-1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (58)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-m-aminophenyl)amide (59)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (60)2-(4-dimethylaminopyridyl)-l H-benzimidazole-4-(N-p-aminophenyl)amide (61)(L)-2-(3-pyridazinyl)-1 H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-n itrophenylhydro xyethyl)]amide (62)(L)-2-(3-pyridazinyl)-1 H-benzimidazole-4-[N-(l -hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (63)2-(3-pyridazinyl)-1 H-benzimidazole-4-[N-(l -methyl-2-p-chlorophenylhydroxyethyl)]a mide (64)2-(3-pyridazinyl)-IH-benzimidazole-4-(N-o-fluorophenyl) amide (65)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-m-fluorophenyl) amide (66)2-(3-pyridazinyl)-IH-benzimidazole-4-(N-p-fluorophenyl) amide (67)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl) amide (68)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-o-aminophenyl) amide (69)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl) amide (70)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-aminophenyl) amide (71)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (72)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-p-aminophenyl) amide (73)(L)-2-(2-N-methyl-4-N-methylpiperazinyl)- I H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-n itrophenyl hydroxyethy l)] am ide (74)(L)-2-(2-N-methyl-4-N-methylpiperazinyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]am ide (75)2-(2 -N-methyl -4-N-m ethyl piperazinyl)- I H-benzimidazole-4-[N-(1-methyl-2-p-chlorop henylhydroxyethyl)]amide (76)2-(2-N-methyl-4-N-methylpiperazinyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide (77)2-(2-N-methyl-4-N-methylpiperazinyl)- I H-benzimidazole-4-(N-m-fluorophenyl)amide (78)2-(2-N-methyl-4-N-methylpiperazinyl)-1 H-benzimidazole-4-(N-p-fluorophenyl)amide (79)2-(2-N-methyl-4-N-methylpiperazinyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (80)2-(2 N-methyl-4-N-methylpiperazinyl)-IH-benzimidazole-4-(N-o-aminophenyl)amide (81 )2-(2 N-methyl-4-N-methylpiperazinyl)-IH-benzimidazole-4-(N-m-hydroxyphenyl)amide (82)2-(2-N-methyl-4-N-methylpiperazinyl)-I H-benzimidazole-4-(N-m-aminophenyl)amide (83)2-(2-N-methyl-4-N-methylpiperazinyl)- I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (84)2-(2-N-methyl-4-N-methylpiperazinyl)-I H-benzimidazole-4-(N-p-am inophenyl)amide (85)(L)-2-(2-pyrazinyl)- I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydrox yethyl)]amide (86)(L)-2-(2-pyrazinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (87)2-(2-pyrazinyl)- I H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (88)2-(2-pyrazinyl)- I H-benzim idazole-4-(N-o-fl uorophenyl)am ide (89)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-m-fluorophenyl)am ide (90)2-(2-pyrazinyl)- I H-benzim idazole-4-(N-p-fluorophenyl)amide (91)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)am ide (92)2-(2-pyrazinyl)- I H-benzimidazole-4-(N-o-aminophenyl)am ide (93)2-(2-pyrazinyl)- I H-benzimidazole-4-(N-m-hydroxyphenyl)amide (94)2-(2-pyrazinyl)- I H-benzimidazole-4-(N-m-aminophenyl)amide (95)2-(2-pyrazinyl)- I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (96)2-(2-pyrazinyl)- I H-benzimidazole-4-(N-p-am inophenyl)amide (97)(L)-2-N-piperazinyl- I H-benzim idazole-4-[N-(I -hydroxymethyl-2-p-nitrophenylhydrox yethyl)]amide (98)(L)-2-N-piperazinyl- I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (99)2-N-piperazinyl-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (l 00)2-N-piperazinyl-1 H-benzim idazole-4-(N-o-fluorophenyl)am ide (10 1)2-N-piperazinyl-1 H-benzimidazole-4-(N-m-fluorophenyl)amide (102)2-N-piperazinyl-I H-benzimidazole-4-(N-p-fluorophenyl)amide (I 03)2-N-piperazinyl- I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (I04)2-N-piperazinyl-1 H-benzimidazole-4-(N-o-aminophenyl)amide (105)2-N-piperazinyl-1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (106)2-N-piperazinyl- I H-benzimidazole-4-(N-m-aminophenyl)amide (107)2-N-piperazinyl- I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (108)2-N-piperazinyl-I H-benzimidazole-4-(N-p-am inophenyl)amide (109)(L)-2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nit rophenylhydroxyethyl)]amide (I 10)(L)-2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-[N-(l -hydroxymethyl-2-p-am inophenylhydroxyethyl)]amide (111)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylh ydroxyethyl)]amide (I 12)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (I13)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-m-fluorophenyl)amide (114)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-p-fluorophenyl)amide (115)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (116)2-(4-methyl-5-am inothiazolyl)- I H-benzimidazole-4-(N-o-am inophenyl)amide (117)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-m-hydroxyphenyl)amide (I 18)2-(4-methyl-5-aminothiazolyl)-IH-benzimidazole-4-(N-m-aminophenyl)amide (119)2-(4-methyl-5-aminothiazolyl)- I H-benzim idazole-4-(N-p-hydroxyphenyl)amide (120)2-(4-methyl-5-aminothiazolyl)-l H-benzimidazole-4-(N-p-aminophenyl)amide (121)(L)-2-thiazolyl-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (I22)(L)-2-thiazolyl-1 H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-aminophenylhydroxye thyl)]amide (I 23)2-thiazolyl- I H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenylhydroxyethyl)]amide (124)2-thiazolyl- I H-benzimidazole-4-(N-o-fluorophenyl)amide (I 25)2-thiazolyl- I H-benzim idazole-4-(N-m-fluorophenyl)amide (126)2-thiazolyl- I H-benzim idazole-4-(N-p-fl uorophenyl)am ide (127)2-thiazolyl- I H-benzim idazole-4-(N-o-hydroxyphenyl)am ide (128)2-thiazolyl-I H-benzimidazole-4-(N-o-am inophenyl)amide (129)2-thiazolyl-1 H-benzim idazole-4-(N-m-hydroxyphenyl)am ide (130)2-thiazolyl-I H-benzimidazole-4-(N-m-am inophenyl)amide (131)2-thiazolyl-1 H-benzimidazole-4-(N-p-hydroxyphenyl)amide (132)2-thiazolyl-I H-benzimidazole-4-(N-p-aminophenyl)amide (133)(L)-5-thiazolyl-I H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (I34)(L)-5-thiazolyl-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-am inophenylhydroxye thyl)]amide (135)5-thiazolyl-I H-benzim idazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (136)5-thiazolyl-I H-benzimidazole-4-(N-o-fluorophenyl)amide (137)5-thiazolyl-I H-benzimidazole-4-(N-m-fluorophenyl)amide (13 38)5-thiazolyl- H-benzim idazole-4-(N-p-fluorophenyl)am ide (I 39)5-thiazolyl- I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (I 40)5-thiazolyl- I H-benzimidazole-4-(N-o-am inophenyl)amide (141)5-thiazolyl-1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (I42)5-thiazolyl-1 H-benzimidazole-4-(N-m-aminophenyl)amide (143)5-thiazolyl- I H-benzim idazole-4-(N-p-hydroxyphenyl)am ide (I 44)5-thiazolyl- I H-benzimidazole-4-(N-p-aminophenyl)amide (145)(L)-2-(3,4,5-trihydroxyphenyl)-I H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-nitrop henylhydroxyethyl) ]amide (146)(L)-2-(3,4,5-trihydroxyphenyl)-1 H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (147)2-(3,4,5-trihydroxyphenyl)- I H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenylhydro xyethyl)]amide (148)2-(3,4,5-trihydroxyphenyl)-I H-benzimidazole-4-(N-o-fluorophenyl)amide (I 49)2-(3,4, 5-trihydroxyphenyl)-I H-benzim idazole-4-(N-m-fluorophenyl)am i de (150)2-(3,4,5-trihydroxyphenyl)-1 H-benzim idazole-4-(N-p-fluorophenyl)amide (151)2-(3,4,5-trihydroxyphenyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (152)2-(3,4,5-trihydroxyphenyl)-1 H-benzimidazole-4-(N-o-aminophenyl)am ide (153)2-(3,4,5-trihydroxyphenyl)-1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (154)2-(3,4,5-trihydroxyphenyl)-I H-benzimidazole-4-(N-m-aminophenyl)am ide (155)2-(3,4,5-trihydroxyphenyl)-1 H-benzimidazole-4-(N-p-hydroxyphenyl)amide (156)2-(3,4,5-trihydroxyphenyl)-I H-benzim idazole-4-(N-p-aminophenyl)amide (157)(L)-2-(2,3,4-trihydroxyphenyl)-I H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (158)(L)-2-(2,3,4-trihydroxyphenyl)-1 H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (159)2-(2,3,4-trihydroxyphenyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydro xyethyl)]amide (160)2-(2,3,4-trihydroxyphenyl)-l H-benzimidazole-4-(N-o-fluorophenyl)amide (161)2-(2,3,4-trihydroxyphenyl)-I H-benzimidazole-4-(N-m-fluorophenyl)amide (162)2-(2,3,4-trihydroxyphenyl)-I H-benzimidazole-4-(N-p-fluorophenyl)amide (163)2-(2,3,4-trihydroxyphenyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (164)2-(2,3,4-trihydroxyphenyl)- I H-benzim idazole-4-(N-o-am inophenyl)am ide (165)2-(2,3,4-trihydroxyphenyl)-I H-benzimidazole-4-(N-m-hydroxyphenyl)amide (166)2-(2,3,4-trihydroxyphenyl)-I H-benzim idazole-4-(N-m-aminophenyl)amide (167)2-(2,3,4-trihydroxyphenyl)-1 H-benzimidazole-4-(N-p-hydroxyphenyl)amide (I 68)2-(2,3,4-trihydroxyphenyl)- l H-benzim idazole-4-(N-p-aminophenyl)am ide (169)(L)-2-(2-pyrimidinyl)-1 H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (170)(L)-2-(2-pyrimidinyl)- I H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-aminophenylhy droxyethyl)]amide (171)2-(2-pyrimidinyl)-1 H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenylhydroxyethyl)]amide (I 72)2-(2-pyrimidinyl)- I H-benzim idazole-4-(N-o-fluorophenyl)am ide (173)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-m-fluorophenyl)am ide (I 74)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N-p-fluorophenyl)amide (175)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (176)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide (177) 2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (178)2-(2-pyrimidinyl)-l H-benzimidazole-4-(N-m-aminophenyl)amide (179)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-p-hydroxyphenyl)amide (180)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-p-aminophenyl)amide (18 1)(L)-2-(2-phenyl-5-pyrimidinyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)lamide (182)(L)-2-(2-phenyl-5-pyrimidinyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]am ide (183)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydr oxyethyl)]amide (184)2-(2- phenyl-5-pyrimidinyl)-IH-benzimidazole-4-(N-o-fluorophenyl)amide (185)2-(2- phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-m-fluorophenyl)amide (186)2-(2- phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-p-fluorophenyl)amide (187)2-(2- phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (188)2-(2- phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-o-am inophenyl)amide (189)2-(2- phenyl-5-pyrimidinyl)-l H-benzimidazole-4-(N-m-hydroxyphenyl)amide (190)2-(2- phenyl-5-pyrimidinyl)-l H-benzimidazole-4-(N-m-aminophenyl)amide (191)2-(2- phenyl-5-pyrimidinyl)- I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (192)2-(2- phenyl-5-pyrimidinyl)-l H-benzimidazole-4-(N-p-am inophenyl)amide (193)(L)-2-(4-am ino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2 -p-nitrophenylhydroxyethyl)]am ide (194)(L)-2-(4-amino-6-chloro-5-pyrim idinyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2 -p-aminophenylhydroxyethyl)]am ide (195)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophe ny l h yd roxyethy l )]amide (196)2-(4-amino-6-chloro-5-pyrim idinyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide (197)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-(N-m-fluorophenyl)amide (198)2-(4-amino-6-chloro-5-pyrimidinyl)-l H-benzimidazole-4-(N-p-fluorophenyl)amide (I 99)2-(4-amino-6-chloro-5-pyrim idinyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (200)2-(4-amino-6-chloro-5-pyrimidinyl)- I H-benzimidazole-4-(N-o-aminophenyl)amide (201)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-m-hydroxyphenyl)amide (202)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-m-aminophenyl)amide (203)2-(4-amino-6-chloro-5-pyrimidinyl)- I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (204)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-p-aminophenyl)amide (205)(L)-2-(2-pyrrolyl)-1 H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (206)(L)-2-(2-pyrrolyl)-1 H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-am inophenylhydro xyethyl)]amide (207)2-(2-pyrrolyl)-I H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (208)2-(2-pyrrolyl)- I H-benzim idazole-4-(N-o-fluorophenyl)amide (209)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-m-fluorophenyl)amide (210)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-p-fluorophenyl)amide (211)2-(2-pyrrolyl)- I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (212)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-o-aminophenyl)am ide (213)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-m-hydroxyphenyl)am ide (214)2-(2-pyrrolyl)-I H-benzim idazole-4-(N-m-aminophenyl)amide (215)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (216)(L)-2-(N-methyl-2-pyrrolyl)- I H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-nitrophe nylhydroxyethyl)]am ide (217)(L)-2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminoph enylhydroxyethyl)]amide (218)2-(N-methyl-2-pyrrolyl)-1 H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenylhydroxy ethyl)]amide (219)2-(N-methyl -2-pyrrolyl)-I H-benzimidazole-4-(N-o-fluorophenyl)amide (220)2-(N-methyl-2-pyrrolyl)- I H-benzimidazole-4-(N-m-fluorophenyl)amide (221)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-p-fluorophenyl)amide (222)2-(N-methyl-2-pyrrolyl)- I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (223)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-o-aminophenyl)amide (224)2-(N-methyl-2-pyrrolyl)- I H-benzimidazole-4-(N-m-hydroxyphenyl)am ide (225)2-(N -m ethyl -2 -pyrrolyl)- I H-benzimidazole-4-(N-m-aminophenyl)amide (226)2-(N-methyl-2-pyrrolyl)- I H-benzim idazole-4-(N-p-hydroxyphenyl)amide (227)(L)-2-(3,5-dimethyl-2-pyrrolyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (228)(L)-2-(3,5-dim ethyl-2-pyrrolyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl -2-p-amino phenylhydroxyethyl)]amide (229)2-(3,5-dimethyl-2-pyrrolyl)- I H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydr oxyethyl)]amide (230)2-(3,5-dimethyl-2-pyrrolyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide (231)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-m-fluorophenyl)amide (232)2-(3,5-dimethyl-2-pyrrolyl)-1 H-benzimidazole-4-(N-p-fluorophenyl)amide (233)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (234)2-(3,5-dimethyl-2-pyrrolyl)- I H-benzimidazole-4-(N-o-aminophenyl)amide (235)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzim idazole-4-(N-m-hydroxyphenyl)amide (236)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-m-aminophenyl)amide (237)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (238)(L)-2-(2-quinolinyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide (239)(L)-2-(2-quinolinyl)-I H-benzimidazole-4-[N-(I-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (240)2-(2-quinolinyl)- I H-benzimidazole-4-[N-(] -methyl-2-p-chlorophenylhydroxyethyl)]amide (241)2-(2-quinolinyl)-I H-benzimidazole-4-(N-o-fluorophenyl)amide (242)2-(2-quinolinyl)-I H-benzimidazole-4-(N-m-fluorophenyl)amide (243)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-p-fluorophenyl)amide (244)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (245)2-(2-quinolinyl)- I H-benzimidazole-4-(N-o-aminophenyl)amide (246)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (247)2-(2-quinolinyl)-1 H-benzim idazole-4-(N-m-aminophenyl)amide (248)2-(2-quinolinyl)- I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (249)(L)-2-(3-quinolinyl)- I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide (250)(L)-2-(3-quinolinyl)-I H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (251)2-(3-quinolinyl)-I H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]a mide (252)2-(3-quinolinyl)- I H-benzimidazole-4-(N-o-fluorophenyl)amide (253)2-(3-quinolinyl)-I H-benzimidazole-4-(N-m-fluorophenyl)amide (254)2-(3-quinolinyl)- I H-benzimidazole-4-(N-p-fluorophenyl)amide (255)2-(3-quinolinyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (256)2-(3-quinolinyl)-l H-benzimidazole-4-(N-o-aminophenyl)amide (257)2-(3-quinolinyl)- I H-benzimidazole-4-(N-m-hydroxyphenyl)amide (25 8)2-(3-quinolinyl)-1 H-benzimidazole-4-(N-m-aminophenyl)amide (259)2-(3-quinolinyl)- I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (260)(L)-2-(2-piperidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (26 1)(L)-2-(2-piperidinyl)- I H-benzimidazole-4-[N-(l -hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide (262)2-(2-piperidinyl)- 1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (263)2-(2-piperidinyl)- I H-benzimidazole-4-(N-o-fluorophenyl)amide (264)2-(2-piperidinyl)-I H-benzimidazole-4-(N-m-fluorophenyl)amide (265)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-p-fluorophenyl)amide (266)2-(2-piperidinyl)- I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (267)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide (268)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (269)2-(2-piperidinyl)-I H-benzimidazole-4-(N-m-am inophenyl)amide (270)2-(2-piperidinyl)- I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (271)(L)-2-(3-piperidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (272)(L)-2-(3-piperidinyl)- l H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide (273)2-(3-piperidinyl)- I H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (274)2-(3-piperidinyl)-I H-benzimidazole-4-(N-o-fluorophenyl)amide (275)2-(3-piperidinyl)-1 H-benzimidazole-4-(N-m-fluorophenyl)amide (276)2-(3-piperidinyl)-I H-benzimidazole-4-(N-p-fluorophenyl)amide (277)2-(3-piperidinyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (278)2-(3-piperidinyl)- l H-benzimidazole-4-(N-o-aminophenyl)amide (279)2-(3-piperidinyl)-1 H-benzim idazole-4-(N-m-hydroxyphenyl)amide (280)2-(3-piperidinyl)- I H-benzimidazole-4-(N-m-am inophenyl)amide (281)2-(3-piperidinyl)-1 H-benzim idazole-4-(N-p-hydroxyphenyl)amide (282)(L)-2-(4-piperidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (283)(L)-2-(4-piperidinyl)-1 H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide (284)2-(4-piperidinyl)-I H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenylhydroxyethyl)]amide (285)2-(4-piperidinyl)- I H-benzimidazole-4-(N-o-fluorophenyl)amide (286)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-m-fluorophenyl)amide (287)2-(4-piperidinyl)- I H-benzimidazole-4-(N-p-fluorophenyl)amide (288)2-(4-piperidinyl)- I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (289)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-o-aminophenyl)am ide (290)2-(4-piperidinyl)- I H-benzimidazole-4-(N-m-hydroxyphenyl)amide (291)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-m-aminophenyl)amide (292)2-(4-piperidinyl)- I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (293)(L)-2-(3-indolyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (294)(L)-2-(3-indolyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl -2-p-aminophenylhydrox yethyl)]amide (295)2-(3-indolyl)-1 H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenylhydroxyethyl)]am ide (296)2-(3-indolyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide (297)2-(3-indolyl)-1 H-benzimidazole-4-(N-m-fluorophenyl)amide (298)2-(3-indolyl)-I H-benzimidazole-4-(N-p-fluorophenyl)amide (299)2-(3-indolyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (300)2-(3-indolyl)-I H-benzimidazole-4-(N-o-am inophenyl)amide (301)2-(3-indolyl)-1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (302)2-(3-indolyl)-I H-benzimidazole-4-(N-m-aminophenyl)amide (303)2-(3-indolyl)-l H-benzimidazole-4-(N-p-hydroxyphenyl)amide (304)(L)-2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (305)(L)-2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (306)2-(2,3,4-trimethoxyphenyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydr oxyethyl)]amide (307)2-(2,3,4-trimethoxyphenyl)- I H-benzim idazole-4-(N-o-fluorophenyl)amide (3 08)2-(2,3,4-trimethoxyphenyl)- I H-benzimidazole-4-(N-m-fluorophenyl)amide (309)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-p-fluorophenyl)amide (310)2-(2,3,4-trimethoxyphenyl)- I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (311)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-o-aminophenyl)amide (312)2-(2,3,4-trimethoxyphenyl)- I H-benzimidazole-4-(N-m-hydroxyphenyl)am ide (313)2-(2,3,4-trimethoxyphenyl)-1 H-benzimidazole-4-(N-m-am inophenyl)amide (314)2-(2,3,4-trimethoxyphenyl)-I H-benzim idazole-4-(N-p-hydroxyphenyl)amide (315)(L)-2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]am ide (316)(L)-2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (317)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-[N-(I -methyl-2-p-chloropheny lhydroxyethyl)]amide (318)2-(3-hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide (319)2-(3 -hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N-m-fluorophenyl)amide (320)2-(3-hydroxyl-4-methoxyphenyl)- I H-benzimidazole-4-(N-p-fluorophenyl)amide (321)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzim idazole-4-(N-o-hydroxyphenyl)amide (322)2-(3-hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide (323)2-(3-hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (324)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-m-aminophenyl)amide (325)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-p-hydroxyphenyl)amide (326)(L)-2-methoxy- I H-benzim idazole-4-[N-(I -hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (327)(L)-2-methoxy- I H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-am inophenylhydroxye thyl)]amide (328)2-methoxy-1 H-benzim idazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (329)2-methoxy- I H-benzimidazole-4-(N-N'-piperidinyl)amide (330)2-methoxy-I H-benzimidazole-4-(N-2-piperazinyl)amide (331 )2-methoxy-I H-benzim idazole-4-(N-2'-benzim idazolyl)am ide (332)2-methoxy- I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (333)2-methoxy-I H-benzimidazole-4-(N-o-am inophenyl)amide (334)2-methoxy- I H-benzimidazole-4-(N-5-benzim idazolonyl)amide (335)2-methoxy-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (336)2-methoxy- I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (337)2-methoxy-1 H-benzimidazole-4-(N-2-imidazolyl)amide (338)2-methoxy-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (339)2-methoxy-I H-benzimidazole-4-(N-(N'-piperazinyl))amide (340)2-methoxy-I H-benzim idazole-4-(N' -ethyl-N-piperazinyl)amide (341)2-methoxy-I H-benzimidazole-4-(N-2-pyrazinyl)amide (342)2-methoxy- I H-benzimidazole-4-(N-2-pyrimidinyl)amide (343)2-methoxy- I H-benzimidazole-4-(N-4-pyrimidinyl)amide (344)2-methoxy-1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (345)2-methoxy- I H-benzimidazole-4-(N-2-pyridyl)amide (346)2-methoxy-I H-benzimidazole-4-(N-3-pyridyl)amide (347)2-methoxy-I H-benzimidazole-4-(N-4-pyridyl)amide (348)2-methoxy-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (349)2-methoxy- I H-benzimidazole-4-(N-5-thiazolyl)amide (350)2-methoxy-I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (351)2-methoxy-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (352)2-methoxy-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (353)2-methoxy-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (354)(L)-2-ethoxy- I H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-nitrophenylhydroxyethyl )]amide (355)(L)-2-ethoxy-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyeth yl)]amide (356)2-ethoxy-I H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenylhydroxyethyl)]amide (357)2-ethoxy- I H-benzim idazole-4-(N-N'-piperidinyl)amide (358)2-ethoxy-1 H-benzim idazole-4-(N-2-piperazinyl)amide (359)2-ethoxy- I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (360)2-ethoxy-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (361)2-ethoxy-I H-benzimidazole-4-(N-o-aminophenyl)amide (362)2-ethoxy- I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (363)2-ethoxy-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (364)2-ethoxy-I H-benzimidazole-4-(N-4'-carboxyl-5' -imidazolyl)amide (365)2-ethoxy- I H-benzimidazole-4-(N-2-imidazolyl)amide (366)2-ethoxy- I H-benzimidazole-4-(N-4'-pyrazolyl)amide (367)2-ethoxy-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide (368)2-ethoxy-1 H-benzim idazole-4-(N'-ethyl-N-piperazinyl)amide (369)2-ethoxy- I H-benzimidazole-4-(N-2-pyrazinyl)amide (370)2-ethoxy- I H-benzimidazole-4-(N-2-pyrimidinyl)amide (371)2-ethoxy-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (372)2-ethoxy-1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (373)2-ethoxy-I H-benzimidazole-4-(N-2-pyridyl)amide (374)2-ethoxy-I H-benzimidazole-4-(N-3-pyridyl)amide (375)2-ethoxy- I H-benzimidazole-4-(N-4-pyridyl)amide (376)2-ethoxy- I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)am ide (377)2-ethoxy-I H-benzimidazole-4-(N-5-thiazolyl)amide (378)2-ethoxy- I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (379)2-ethoxy-1 H-benzim idazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)am ide (3 80)2-ethoxy-1 H-benzim idazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (3 81)2-ethoxy- I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)am ide (3 82)(L)-2-(2,6-dimethyl-2,6-octadienyl)- I H-benzim idazole-4-[N-(I -hydroxymethyl-2-p-ni trophenylhydroxyethyl)]amide (383)(L)-2-(2,6-dimethyl-2,6-octadienyl)- I H-benzim idazole-4-[N-(I -hydroxymethyl-2-p-a minophenylhydroxyethyl)]amide (384)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenyl hydroxyethyl)]amide (385)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzim idazole-4-(N-N'-piperidinyl)amide (386)2-(2,6-dimethyl-2,6-octadienyl)- I H-benzimidazole-4-(N-2-piperazinyl)amide (3 87)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (3 88)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (3 89)2-(2,6-dimethyl-2,6-octadienyl)- I H-benzimidazole-4-(N-o-aminophenyl)amide (390)2-(2,6-dimethyl-2,6-octadienyl)-l H-benzimidazole-4-(N-5-benzimidazolonyl)amide (391)2-(2,6-dimethyl-2,6-octadienyl)- I H-benzimidazole-4-(N-4'-carbonamido-5'-imidazol yl)amide (392)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (393)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-2-iinidazolyl)amide (394)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (395)2-(2,6-dimethyl-2,6-octadienyl)- I H-benzimidazole-4-(N-(N'-piperazinyl))amide (396)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (397)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-2-pyrazinyl)amide (398)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (399)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (400)2-(2,6-dimethyl-2,6-octadienyl)- I H-benzimidazole-4-(N-5-pyrimidinyl)amide (401)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-2-pyridyl)amide (402)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (403)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-4-pyridyl)amide (404)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (405)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-5-thiazolyl)amide (406)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (407)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (408)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidi nyl)amide (409)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (410)(L)-2-pyrazolyl-1 H-benzimidazole--[N-(l -hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (411)(L)-2-pyrazolyl-1 H-benzimidazole--[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (412) 2-pyrazolyl-IH-benzimidazole-4-[N-(I-methyl-2-p-chlorophenylhydroxyethyl)]amide (413) 2-pyrazolyl-1 H-benzim idazole-4-(N-N'-piperidinyl)amide (414) 2-pyrazolyl-1 H-benzimidazole-4-(N-2-piperazinyl)amide (415) 2-pyrazolyl- I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (416) 2-pyrazolyl-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (417) 2-pyrazolyl-l H-benzimidazole-4-(N-o-am inophenyl)amide (418) 2-pyrazolyl- I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (419) 2-pyrazolyl-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (420) 2-pyrazolyl-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (421) 2-pyrazolyl-1 H-benzimidazole-4-(N-2-imidazolyl)amide (422) 2-pyrazolyl-l H-benzimidazole-4-(N-4'-pyrazolyl)amide (423) 2-pyrzazolyl-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide (424) 2-pyrazolyl-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (425) 2-pyrazolyl-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (426) 2-pyrazolyl-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (427) 2-pyrazolyl-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (428) 2-pyrazolyl-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (429) 2-pyrazolyl-1 H-benzimidazole-4-(N-2-pyridyl)amide (430) 2-pyrazolyl-I H-benzimidazole-4-(N-3-pyridyl)amide (431) 2-pyrazolyl-1 H-benzim idazole-4-(N-4-pyridyl)amide (432) 2-pyrazolyl-1 H-benzim idazole-4-(N-4-methyl-5-thiazolyl)amide (433) 2-pyrazolyl-1 H-benzimidazole-4-(N-5-thiazolyl)amide (434) 2-pyrazolyl-lH-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (435) 2-pyrazolyl-lH-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (436) 2-pyrazolyl-IH-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (437) 2-pyrazolyl-l H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (438)(L)-2-(2'-pyridyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (439)(L)-2-(2'-pyridyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (440)2-(2'-pyridyl)-I H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (441) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (442) 2-(2'-pyridyl)-1 H-benzimidazole-4-(N-2-piperazinyl)amide (443) 2-(2'-pyridyl)- I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (444) 2-(2'-pyridyl)- I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (445) 2-(2'-pyridyl)-1 H-benzimidazole-4-(N-o-am inophenyl)amide (446) 2-(2'-pyridyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (447) 2-(2'-pyridyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (448) 2-(2'-pyridyl)- I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (449) 2-(2'-pyridyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (450) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (451) 2-(2'-pyridyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide (452) 2-(2'-pyridyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (453) 2-(2'-pyridyl)- I H-benzimidazole-4-(N-2-pyrazinyl)amide (454) 2-(2'-pyridyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (455) 2-(2'-pyridyl)-1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (456) 2-(2'-pyridyl)- I H-benzimidazole-4-(N-5-pyrimidinyl)amide (457) 2-(2'-pyridyl)- I H-benzimidazole-4-(N-2-pyridyl)amide (458) 2-(2'-pyridyl)- I H-benzimidazole-4-(N-3-pyridyl)amide (459) 2-(2'-pyridyl)-1 H-benzimidazole-4-(N-4-pyridyl)amide (460) 2-(2'-pyridyl)- I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (461)2-(2'-pyridyl)-I H-benzimidazole-4-(N-5-thiazolyl)amide (462)2-(2'-pyridyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (463)2-(2'-pyridyl)- I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (464)2-(2'-pyridyl)- I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (465)2-(2'-pyridyl)- I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (466)(L)-2-(3'-pyridyl} 1 H-benzimidazole-1-[N{ 1-hydroxymethyl-2-p-nitmphenylhydroxyethyl)]amide (467)(L)-2-(3'-pyridyl)- I H-benzim idazole-4-[N-(I -hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (468)2-(3'-pyridyl)-I H-benzimidazole-4-[N-(I -methyl-2-p-chlorophenylhydroxyethyl)]am ide (469)2-(3'-pyridyl)-I H-benzimidazole-4-(N-N'-piperidinyl)amide (470)2-(3'-pyridyl)-I H-benzimidazole-4-(N-2-piperazinyl)amide (471)2-(3'-pyridyl)- I H-benzimidazole-4-(N-2' -benzim idazolyl)amide (472)2-(3'-pyridyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (473)2-(3'-pyridyl)- I H-benzimidazole-4-(N-o-aminophenyl)amide (474)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (475)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (476)2-(3'-pyridyl)-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (477)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (478)2-(3'-pyridyl)-1 H-benzim idazole-4-(N-4'-pyrazolyl)amide (479)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide (480)2-(3'-pyridyl)- I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (481)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (482)2-(3'-pyridyl)- ]H-benzimidazole-4-(N-2-pyrim idinyl)amide (483)2-(3'-pyridyl)-l H-benzimidazole-4-(N-4-pyrimidinyl)amide (484)2-(3'-pyridyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (485)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide (486)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-3-pyridyl)amide (487)2-(3'-pyridyl)- I H-benzimidazole-4-(N-4-pyridyl)amide (488)2-(3'-pyridyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (489)2-(3'-pyridyl)- I H-benzimidazole-4-(N-5-thiazolyl)amide (490)2-(3'-pyridyl)- I H-benzimidazole-4-(N-2.4-dihydroxyl-5-pyrimidinyl)amide (491)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (492)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (493)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (494)(L)-2-(4'-pyridyl}I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (495)(L)-2-(4'-pyridyl)-I H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (496)2-(4'-pyridyl)- I H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (497)2-(4'-pyridyl)- I H-benzi m idazole-4-(N-N'-pi peridinyl)am ide (498)2-(4'-pyridyl)-1 H-benzim idazole-4-(N-2-piperazinyl)amide (499)2-(4'-pyridyl)- I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (5 00)2-(4'-pyridyl)- I H-benzim idazole-4-(N-o-hydroxyphenyl)amide (5 01)2-(4'-pyridyl)- I H-benzi m idazole-4-(N-o-am inophenyl)am ide (502)2-(4'-pyridyl)-I H-benzimidazole-4-(N-5-benzim idazolonyl)amide (503)2-(4'-pyridyl)- I H-benzim idazole-4-(N-4' -carbonamido-5' -im idazolyl)am ide (504)2-(4'-pyridyl)-1 H-benzim idazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (505)2-(4'-pyridyl)-I H-benzimidazole-4-(N-2-imidazolyl)amide (506)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide (507)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))am ide (508)2-(4'-pyridyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (509)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (510)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (511)2-(4'-pyridyl)-1 H-benzim idazole-4-(N-4-pyri mid i nyl)am ide (512)2-(4'-pyridyl)-1 H-benzim idazole-4-(N-5-pyrimi d inyi)am ide (513)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide (514)2-(4'-pyridyl)- I H-benzimidazole-4-(N-3-pyridyl)amide (515)2-(4'-pyridyl)-l H-benzimidazole-4-(N-4-pyridyl)amide (516)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (517)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-5-thiazolyl)amide (518)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (519)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (520)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (521)2-(4'-pyridyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (522)(L)-2-(2'-imidazolyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (523)(L)-2-(2'-imidazolyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhy droxyethyl)]amide (524)2-(2'-imidazolyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (525)2-(2'-imidazolyl)-1 H-benzimidazole-4-(N-N'-piperidinyl)amide (526)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-2-piperazinyl)amide (527)2-(2'-imidazolyl)- I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (528)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (529)2-(2'-imidazolyl)-1 H-benzim idazole-4-(N-o-am inophenyl)am ide (530)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (5 31)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-4'-carbonamido-5' -imidazolyl )amide (532)2-(2'-imidazolyl)-1 H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (533)2-(2'-imidazolyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (534)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (535)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-(N'-piperazinyl))amide (536)2-(2'-imidazolyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)am ide (537)2-(2'-imidazolyl)- I H-benzimidazole-4-(N-2-pyrazinyl)amide (538)2-(2'-imidazolyl)- I H-benzimidazole-4-(N-2-pyrimidinyl)amide (539)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (540)2-(2'-imidazolyl)-l H-benzimidazole-4-(N-5-pyrimidinyl)amide (541)2-(2'-imidazolyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide (542)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (543)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-4-pyridyl)amide (544)2-(2'-imidazolyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (545)2-(2'-imidazolyl)- I H-benzimidazole-4-(N-5-thiazolyl)amide (546)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (547)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (548)2-(2'-imidazolyl)- I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (549)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (550)2-(4-methoxypyridyl)- I H-benzim idazole-4-(N-N'-piperidinyl)amide (551)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-2-piperazinyl)amide (552)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-2'-benzim idazolyl)amide (553)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (554)2-(4-methoxypyridyl)- I H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (555)2-(4-methoxypyridyl)-I H-benzim idazole-4-(N-4'-carboxyl-5'-imidazolyl)am ide (556)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-2-imidazolyl)amide (55 7)2-(4-methoxypyridyl)- I H-benzim idazole-4-(N-4'-pyrazolyl)am ide (558)2-(4-methoxypyridyl)- I H-benzimidazole-4-(N-(N'-piperazinyl))amide (559)2-(4-methoxypyridyl)-I H-benzim idazole-4-(N'-ethyl-N-piperazinyl)am ide (5 60)2-(4-methoxypyridyl)-1 H-benzim idazole-4-(N-2-pyrazinyl )amide (561)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (562)2-(4-methoxypyridyl)- I H-benzimidazole-4-(N-4-pyrimidinyl)am ide (563)2-(4-methoxypyridyl)-1 H-benzi midazole-4-(N-5 -pyrim idinyl)am ide (564)2-(4-methoxypyridyl)- I H-benzi midazole-4-(N-2-pyridyl)am ide (565)2-(4-methoxypyridyl)- I H-benzimidazole-4-(N-3-pyridyl)amide (566)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-4-pyridyl)amide (5 67)2-(4-methoxypyridyl)- I H-benzimidazole-4-(N-4-methyl -5-thiazolyl)amide (568)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-5-thiazolyl)am ide (569)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (570)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (571)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (572)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (573)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-N'-piperidinyl)amide (574)2-(6-methoxypyridyl)- l H-benzim idazole-4-(N-2-piperazinyl)amide (575)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (576)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (577)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (578)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (579)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (580)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (581)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-(N'-piperazinyl))amide (582)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (5 83)2-(6-methoxypyridyl)-1 H-benzim idazole-4-(N-2-pyrazinyl)amide (584)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (585)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (586)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (587)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-2-pyridyl)amide (588)2-(6-methoxypyridyl)-l H-benzimidazole-4-(N-3-pyridyl)amide (5 89)2-(6-methoxypyridyl)- I H-benzimidazole-4-(N-4-pyridyl)am ide (5 90)2-(6-methoxypyridyl)- I H-benzim idazole-4-(N -4-m ethyl -5 -thiazolyl)am ide (591)2-(6-methoxypyridyl)-l H-benzimidazole-4-(N-5-thiazolyl)amide (592)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (593)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (594)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (595)2-(6-methoxypyridyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrim idinyl)amide (596)2-(4-dimethylaminopyridyl)- I H-benzim idazole-4-(N-N'-piperidinyl)am ide (597)2-(4-dimethylaminopyridyl)- I H-benzimidazole-4-(N-2-piperazinyl))amide (598)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (599)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-5-benzim idazolonyl)amide (600)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (601)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (602)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-2-imidazolyl)amide (603)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide (604)2-(4-dimethylaminopyridyl)-1 H-benzim idazole-4-(N-(N'-piperazinyl))amide (605)2-(4-dimethylaminopyridyl)-1 H -benzi m i dazole-4-(N '-ethyl -N -piperazinyl)am ide (606)2-(4-dimethylaminopyridyl)- I H-benzimidazole-4-(N-2-pyrazinyl)amide (607)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (608)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (609)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (610)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-2-pyridyl)amide (611)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (612)2-(4-dimethylaminopyridyl)-1 H-benzim idazole-4-(N-4-pyri dyl)am ide (613)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (614)2-(4-dimethylaminopyridyl)-I H-benzim idazole-4-(N-5-thiazolyl)amide (615)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (616)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (617)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (618)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (619)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-N'-piperidinyl)amide (620)2-(3-pyridazinyl)- I H-benzimidazole-4-(N-2-piperazinyl))amide (621)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)amide (622)2-(3-pyridazinyl)- I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (623)2-(3-pyridazinyl)- I H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (624)2-(3-pyridazinyl)-I H-benzim idazole-4-(N-4'-carboxyl-5'-imidazolyl)am ide (625)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-2-imidazolyl)am ide (626)2-(3-pyridazinyl)-1 H-benzim idazole-4-(N-4'-pyrazolyl)am ide (627)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide (628)2-(3-pyridazinyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (629)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (630)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (631)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (632)2-(3-pyridazinyl)-1 H-benzim idazole-4-(N-5-pyrimidinyl)amide (633)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide (634)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (635)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-4-pyridyl)amide (636)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (637)2-(3-pyridazinyl)-1 H-benzim idazole-4-(N-5-thiazolyl)amide (638)2-(3-pyridazinyl)-l H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (639)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (640)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (641)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (642)2-(2-N-methyl-4-N-methylpiperazinyl)-I H-benzim idazole-4-(N-N'-piperidinyl)amide (643)2-(2-N-methyl-4- N-methylpiperazinyl)-1 H-benzimidazole-4-(N-2-piperazinyl))amide (644)2-(2-N-methyl-4-N-methylpiperazinyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)amide (645)2-(2-N-methyl-4-N-methylpiperazinyl)-I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (646)2-(2-N-methyl-4-N-methylpiperazinyl)-I H-benzimidazole-4-(N-4'-carbonamido-5'-imid azolyl)amide (647)2-(2-N-methyl-4-N-methylpiperazinyl)- I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazol yl)amide (648)2-(2-N-methyl-4- N-methylpiperazinyl)-I H-benzimidazole-4-(N-2-imidazolyl)amide (649)2-(2-N-methyl-4- N-methylpiperazinyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (650)2-(2-N-methyl-4- N-methylpiperazinyl)- I H-benzimidazole-4-(N-(N'-pi perazinyl))amide (651)2-(2-N-methyl-4-N-methylpiperazinyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (652)2-(2-N-methyl-4- N-methylpiperazinyl)- I H-benzimidazole-4-(N-2-pyrazinyl)amide (653)2-(2-N-methyl-4- N-methylpiperazinyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (654)2-(2-N-methyl-4- N-methylpiperazinyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (655)2-(2-N-methyl-4- N-methylpiperazinyl)-1 H-benzim idazole-4-(N-5-pyri midinyl)am ide (656)2-(2-N-methyl-4- N-methylpiperazinyl)- I H-benzim idazole-4-(N-2-pyridyl)amide (657)2-(2-N-methyl-4- N-methylpiperazinyl)- I H-benzim idazole-4-(N-3-pyridyl)amide (658)2-(2-N-methyl-4- N-methylpiperazinyl)- I H-benzimidazole-4-(N-4-pyridyl)amide (659)2-(2-N-methyl-4-N-methylpiperazinyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (660)2-(2-N-methyl-4- N-methylpiperazinyl )- I H-benzimidazole-4-(N-5-thiazolyl)am ide (661)2-(2-N-methyl-4-N-methylpiperazinyl)-1 H-benzim idazole-4-(N-2,4-dihydroxyl-5 -pyrim i dinyl)amide (662)2-(2-N-methyl-4-N-methylpiperazinyl)-I H-benzim idazole-4-(N-4,6-dimethoxy-2-pyrim i dinyl)amide (663)2-(2-N-methyl-4-N-methylpiperazinyl)-I H-benzim idazole-4-(N-4-chloro-6-am ino-2-pyri midinyl)amide (664)2-(2-N-methyl-4-N-methylpiperazinyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidi nyl)amide (665)2-(2-pyrazinyl)-1 H-benzim idazole-4-(N-N'-piperidinyl)amide (666)2-(2-pyrazinyl)-1 H-benzimidazole-4-(N-2-piperazinyl))amide (667)2-(2-pyrazinyl)-1 H-benzim idazole-4-(N-2' -benzim idazolyl)amide (668)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (669)2-(2-pyrazinyl)-1 H-benzimidazole-4-(N-4' -carbonam ido-5'-im i dazolyl)am ide (670)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (671)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-2-imidazolyl)amide (672)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (673)2-(2-pyrazinyl)- I H-benzimidazole-4-(N-(N'-piperazinyl))amide (674)2-(2-pyrazinyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (675)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-2-pyrazinyl)amide (676)2-(2-pyrazinyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (677)2-(2-pyrazinyl)-1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (678)2-(2-pyrazinyl)-1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (679)2-(2-pyrazinyl)- l H-benzim idazole-4-(N-2-pyridyl)amide (680)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (681)2-(2-pyrazinyl)- l H-benzim idazole-4-(N-4-pyridyl)amide (682)2-(2-pyrazinyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (683)2-(2-pyrazinyl)-1 H-benzimidazole-4-(N-5-thiazolyl)amide (684)2-(2-pyrazinyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (685)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (686)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (687)2-(2-pyrazinyl)-1 H-benzim idazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (688)2-(2-piperazinyl)- l H-benzim idazole-4-(N-N'-piperidinyl)amide (689)2-(2-piperazinyl)- I H-benzimidazole-4-(N-2-piperazinyl))amide (690)2-(2-piperazinyl)-1 H-benzim idazole-4-(N-2'-benzim idazolyl)am ide (691)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (692)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (693)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (694)2-(2-piperazinyl)- I H-benzimidazole-4-(N-2-imidazolyl)amide (695)2-(2-piperazinyl)-1 H-benzim idazole-4-(N-4'-pyrazolyl)amide (696)2-(2-piperazinyl)-1 H-benzim idazole-4-(N-(N' -piperazinyl))am i de (697)2-(2-piperazinyl)-1 H-benzim idazole-4-(N' -ethyl-N-piperaziny l)am ide (698)2-(2-piperazinyl)- I H-benzimidazole-4-(N-2-pyrazinyl)amide (699)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (700)2-(2-piperazinyl)- I H-benzimidazole-4-(N-4-pyrimidinyl)amide (701)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (702)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide (703)2-(2-piperazinyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (704)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-4-pyridyl)amide (705)2-(2-piperazinyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (706)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-5-thiazolyl)amide (707)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (708)2-(2-piperazinyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (709)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (710)2-(2-piperazinyl)-I H-benzim idazole-4-(N-4, 6-dichloro-5-pyrim idinyl)am ide (711)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-N'-piperidinyl)amide (712)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-2-piperazinyl))amide (713)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (714)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-5-benzimidazolonyl)am ide (715)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (716)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (717)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-2-imidazolyl)amide (718)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (719)2-(4-methyl-5-aminothiazolyl)- I H-benzim i dazol e-4-(N -(N' -piperazinyl ))amide (720)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (721)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-2-pyrazinyl)amide (722)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-2-pyrim idinyl)am ide (723)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (724)2-(4-methyl-5-aminothiazolyl)- I H-benzimidazole-4-(N-5-pyrim idinyl)am ide (725)2-(4-methyl-5-aminothiazolyl)-I H-benzim idazole-4-(N-2-pyridyl)am i de (726)2-(4-methyl-5-aminothiazolyl)-I H-benzim idazole-4-(N-3-pyridyl)am ide (727)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-4-pyridyl)amide (728)2-(4-methyl-5-aminothiazolyl)- I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (729)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-5-thiazolyl)amide (730)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (731)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (732)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidi nyl)amide (733)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (734)2-(2-thiazolyl)- I H-benzimidazole-4-(N-N'-piperidinyl)amide (735)2-(2-thiazolyl)- I H-benzimidazole-4-(N-2-piperazinyl))amide (736)2-(2-thiazolyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)am ide (737)2-(2-thiazolyl)-1 H-benzim idazole-4-(N-5-benzimidazolonyl)amide (73 8)2-(2-thiazolyl) 1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (739)2-(2 thiazolyl)-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (740)2-(2-thiazolyl)- I H-benzimidazole-4-(N-2-imidazolyl)amide (741)2-(2-thiazolyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (742)2-(2 thiazolyl)-I H-benzimidazole-4-(N-(N'-piperazinyl))amide (743)2-(2-thiazolyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (744)2-(2-thiazolyl)- I H-benzimidazole-4-(N-2-pyrazinyl)am ide (745)2-(2-thiazolyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (746)2-(2-thiazolyl)- I H-benzimidazole-4-(N-4-pyrimidinyl)amide (747)2-(2-thiazolyl)-1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (748)2-(2-thiazolyl)-1 H -benzimidazole-4-(N-2-pyridyl)am ide (749)2-(2-thiazolyl)-1 H-benzimidazole-4-(N-3-pyridyl)amide (750)2-(2-thiazolyl)- I H-benzimidazole-4-(N-4-pyridyl)amide (751)2-(2-thiazolyl)-l H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (752)2-(2-thiazolyl)-1 H-benzimidazole-4-(N-5-thiazolyl)amide (753)2-(2-thiazolyl)-l H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (754)2-(2-thiazolyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (755)2-(2-thiazolyl)-I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (756)2-(2-thiazolyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (757)2-(5-thiazolyl)-1 H-benzimidazole-4-(N-N'-piperidiny))amide (758)2-(5-thiazolyl)-I H-benzimidazole-4-(N-2-piperazinyl))amide (759)2-(5-thiazolyl)- I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (760)2-(5-thiazolyl)-I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (761)2-(5-thiazolyl)-1 H-benzimidazole-4-(N-4' -carbonam ido-5'-im idazolyl)am ide (762)2-(5-thiazolyl)-1 H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (763)2-(5-thiazolyl)- I H-benzimidazole-4-(N-2-imidazolyl)amide (764)2-(5-thiazolyl)- l H-benzimidazole-4-(N-4'-pyrazolyl)am ide (765)2-(5-thiazolyl)- I H-benzimidazole-4-(N-(N'-piperazinyl))amide (766)2-(5-thiazolyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (767)2-(5-thiazolyl)-I H-benzimidazole-4-(N-2-pyrazinyl)amide (768)2-(5-thiazolyl)- I H-benzimidazole-4-(N-2-pyrimidinyl)amide (769)2-(5-thiazolyl)- I H-benzim idazole-4-(N-4-pyrim idinyl)amide (770)2-(5-thiazolyl)- I H-benzimidazole-4-(N-5-pyrimidinyl)amide (771)2-(5-thiazolyl)-1 H-benzimidazole-4-(N-2-pyridyl)am ide (772)2-(5-thiazolyl)- I H-benzimidazole-4-(N-3-pyridyl)amide (773)2-(2-thiazolyl)-I H-benzimidazole-4-(N-4-pyridyl)amide (774)2-(5-thiazolyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (775)2-(5-thiazolyl)- I H-benzimidazole-4-(N-5-thiazolyl)amide (776)2-(5-thiazolyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (777)2-(5-thiazolyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (778)2-(5-thiazolyl)- I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (779)2-(5-thiazolyl)- I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (780)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-N'-piperidinyl)amide (781)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-2-piperazinyl))amide (782)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (783)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (784)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (785)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (786)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N-2-imidazolyl)amide (787)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N-4'-pyrazolyl)amide (788)2-(2-pyrimidinyl)-1 H-benzim idazole-4-(N-(N' -piperazinyl))amide (789)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (790)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (791)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (792)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N-4-pyrimidinyl)amide (793)2-(2-pyrimidinyl)-1 H-benzim idazole-4-(N-5-pyrim idinyl)amide (794)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N-2-pyridyl)amide (795)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N-3-pyridyl)amide (796)2-(2- pyrimidinyl)- I H-benzimidazole-4-(N-4-pyridyl)amide (797)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (798)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-5-thiazolyl)amide (799)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (800)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrim idinyl)am ide (801)2-(2-pyrimidinyl)-l H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrim idinyl)amide (802)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (803)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-N'-piperidinyl)amide (804)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2-piperazinyl))amide (805)2-(2-phenyl-5-pyrimidinyl)-I H-benzim idazole-4-(N-2' -benzim idazolyl)am ide (806)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (807)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (808)2-(2-phenyl-5-pyrimidinyl)- I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (809)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (810)2-(2-phenyl-5-pyrimidinyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)am ide (811 )2-(2-phenyl-5-pyrimidinyl)-I H-benzim idazole-4-(N-(N' -piperazinyl))amide (812)2-(2-phenyl-5-pyrimidinyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)am ide (813)2-(2-phenyl-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-pyrazinyl)amide (814)2-(2-phenyl-5-pyrimidinyl)-1 H-benzim idazole-4-(N-2-pyrim idinyl)am ide (815)2-(2-phenyl-5-pyrimidinyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (816)2-(2-phenyl-5-pyrimidinyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (81 7)2-(2-phenyl-5-pyrimidinyl)-I H-benzi m idazole-4-(N-2-pyridyl)am ide (818)2-(2-phenyl-5-pyrimidinyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (819)2-(2-phenyl-5-pyrimidinyl)-1 H-benzim idazole-4-(N-4-pyridyl)am ide (820)2-(2-phenyl-5-pyrimidinyl)- I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (821)2-(2-phenyl-5-pyrim idinyl)-I H-benzim idazole-4-(N-5 -thiazolyl)am ide (822)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (823)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (824)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (825)2-(2-phenyl-5-pyrimidinyl)- I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (826)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzim idazole-4-(N-N'-piperidinyl)amide (827)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-piperazinyl))amide (828)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (829)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (830)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-4'-carbonamido-5'-imidaz olyl)amide (831)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (832)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (833)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (834)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzim idazol e-4-(N-(N'-piperazinyi))am ide (835)2-(4-amino-6-chloro-5-pyrimidinyl)- I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (836)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-pyrazinyl)amide (837)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (838)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (839)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (840)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-pyridyl)amide (841)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-(N-3-pyridyl)amide (842)2-(4-amino-6-chloro-5-pyrimidinyl)- I H-benzimidazole-4-(N-4-pyridyl)amide (843)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (844)2-(4-amino-6-chloro-5-pyrimidinyl)- I H-benzimidazole-4-(N-5-thiazolyl)amide (845)2-(4-amino-6-chloro-5-pyrimidinyl)- I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidi nyl)amide (846)2-(4-amino-6-chloro-5-pyrimidinyl)- I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidin yl)amide (847)2-(4-amino-6-chloro-5-pyrimidinyl)- I H-benzim idazole-4-(N-4-chloro-6-amino-2-pyrimi dinyl)amide (848)2-(4-amino-6-chloro-5-pyrimidinyl)- I H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl )amide (849)2-(2-pyrrolyl)- I H-benzimidazole-4-(N-N'-piperidinyl)amide (850)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-2-piperazinyl))amide (851)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)amide (852)2-(2-pyrrolyl)- I H-benzimidazole-4-(N-5-benzim idazolonyl)amide (853)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-4'- carbonamido -5'-imidazolyl)amide (854)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (855)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (856)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide (85 7)2-(2-pyrrolyl)-I H-benzim idazole-4-(N-(N'-piperazinyl))am ide (858)2-(2-pyrrolyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (859)2-(2-pyrrolyl)-I H-benzim idazole-4-(N-2-pyrazinyl)amide (860)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (861)2-(2-pyrrolyl)- I H-benzimidazole-4-(N-4-pyrimidinyl)amide (862)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (863)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide (864)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-3-pyridyl)amide (865)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-4-pyridyl)amide (866)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (867)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-5-thiazolyl)amide (868)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (869)2-(2-pyrrolyl)- I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (870)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (871)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (872)2-(N-methyl-2-pyrrolyl)- I H-benzim idazole-4-(N-N'-piperidinyl)amide (873)2-(N-methyl-2-pyrrolyl)- I H-benzim idazole-4-(N-2-piperazinyl))am ide (874)2-(N-methyl-2-pyrrolyl)-1 H-benzim idazole-4-(N-2'-benzimidazolyl)amide (875)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (876)2-(N-methyl-2-pyn-olyl)- l H-benzim idazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (877)2-(N-methyl-2-pyrrolyl)-1 H-benzim idazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (878)2-(N-methyl-2-pyrrolyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (879)2-(N-methyl-2-pyrrolyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide (880)2-(N-methyl-2-pyrrolyl)- I H-benzimidazole-4-(N-(N'-piperazinyl))am ide (881)2-(N-methyl-2-pyrrolyl)- I H-benzim idazole-4-(N'-ethyl-N-piperazinyl)amide (882)2-(N-methyl-2-pyrrolyl)- I H-benzimidazole-4-(N-2-pyrazinyl)amide (883)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (884)2-(N-methyl-2-pyrrolyl)-1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (885)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (886)2-(N-methyl-2-pyrrolyl)-1 H-benzim idazole-4-(N-2-pyridyl)amide (887)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (888)2-(N-methyl-2-pyrrolyl)- I H-benzimidazole-4-(N-4-pyridyl)amide (8 89)2-(N-methyl-2-pyrrolyl)- I H-benzim i dazole-4-(N-4-methyl-5 -th i azolyl)am ide (890)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-5-thiazolyl)amide (891)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (892)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (893)2-(N-methyl-2-pyrrolyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (894)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (895)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzim idazole-4-(N-N'-piperidinyl)am ide (896)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-2-piperazinyl))amide (897)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (898)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzim idazole-4-(N-5-benzim idazolonyl)amide (899)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (900)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzim idazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (901)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-2-imidazolyl)am ide (902)2-(3,5-dimethyl-2-pyrrolyl)- I H-benzimidazole-4-(N-4'-pyrazolyl)amide (903)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-(N'-piperazinyl))amide (904)2-(3,5- dmethyl-2-pyrrolyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (905)2-(3,5-dimethyl-2-pyrrolyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (906)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (907)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (908)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (909)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-2-pyridyl)amide (910)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (911)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-4-pyridyl)amide (912)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (913)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-5-thiazolyl)amide (914)2-(3,5-dimethyl-2-pyrrolyl)-1 H-benzim idazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (915)2-(3,5-dimethyl-2-pyrrolyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (916)2-(3,5-dimethyl-2-pyrrolyl)-1 H-benzim idazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (917)2-(3,5-dimethyl-2-pyrrolyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)am ide (918)2-(2-quinolinyl)- I H-benzimidazole-4-(N-N'-piperidinyl)amide (919)2-(2-quinolinyl)- I H-benzimidazole-4-(N-2-piperazinyl))amide (920)2-(2-quinolinyl)-1 H-benzim idazole-4-(N-2'-benzimidazolyl)amide (921)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (922)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-4'-carbonam ido-5'-imidazolyl)amide (923)2-(2-quinolinyl)-l H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (924)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (925)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide (926)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide (927)2-(2-quinolinyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (928)2-(2-quinolinyl)- I H-benzimidazole-4-(N-2-pyrazinyl)amide (929)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (930)2-(2-quinolinyl)- I H-benzim idazole-4-(N-4-pyrimidinyl)am ide (931)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (932)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide (933 )2-(2-quinolinyl)-1 H-benzim idazole-4-(N-3-pyridyl)amide (934)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-4-pyridyl)amide (935)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (936)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-5-thiazolyl)amide (93 7)2-(2-quinolinyl)-1 H-benzim idazole-4-(N-2,4-dihydroxyl-5 -pyrim idinyl)am ide (938)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (939)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (940)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (941)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-N'-piperidinyl)amide (942)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2-piperazinyl))amide (943)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)amide (944)2-(2-piperidinyl)- I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (945)2-(2-piperidinyl)-1 H-benzim idazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (946)2-(2-piperidinyl)-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (947)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (948)2-(2-piperidinyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (949)2-(2-piperidinyl)-I H-benzimidazole-4-(N-(N'-piperazinyl))amide (950)2-(2-piperidinyl)- I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (951)2-(2-piperidinyl)-I H-benzimidazole-4-(N-2-pyrazinyl)amide (952)2-(2-piperidinyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (953)2-(2-piperidinyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (954)2-(2-piperidinyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (955)2-(2-piperidinyl)-I H-benzimidazole-4-(N-2-pyridyl)amide (956)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-3-pyridyl)amide (957)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-4-pyridyl)amide (958)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (959)2-(2-piperidinyl)-I H-benzimidazole-4-(N-5-thiazolyl)amide (960)2-(2-piperidinyl)- I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (961)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (962)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (963)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (964)2-(3-piperidinyl)- I H-benzimidazole-4-(N-N'-piperidinyl)amide (965)2-(3-piperidinyl)- I H-benzim idazole-4-(N-2-piperazinyl))amide (966)2-(3-piperidinyl)-1 H-benzim idazole-4-(N-2'-benzimidazolyl)amide (967)2-(3-piperidinyl)-1 H-benzimidazole-4-(N-S-benzim idazolonyl)amide (968)2-(3-piperidinyl)- I H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (969)2-(3-piperidinyl)- I H-benzim idazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (970)2-(3-piperidinyl)- I H-benzimidazole-4-(N-2-imidazolyl)amide (971)2-(3-piperidinyl)- I H-benzim idazole-4-(N-4'-pyrazolyl)amide (972)2-(3-piperidinyl)- I H-benzimidazole-4-(N-(N'-piperazinyl))amide (973)2-(3-piperidinyl)- I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (974)2-(3-piperidinyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (975)2-(3-piperidinyl)- I H-benzimidazole-4-(N-2-pyrimidinyl)amide (976)2-(3-piperidinyl)- I H-benzimidazole-4-(N-4-pyrimidinyl)amide (977)2-(3-piperidinyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (978)2-(3-piperidinyl)- I H-benzimidazole-4-(N-2-pyridyl)amide (979)2-(3-piperidinyl)- I H-benzimi dazole-4-(N-3-pyridyl)amide (980)2-(3-piperidinyl)- I H-benzimidazole-4-(N-4-pyridyl)amide (981)2-(3-piperidinyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (982)2-(3-piperidinyl)- I H-benzimidazole-4-(N-5-thiazolyl)amide (983)2-(3-piperidinyl)- I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (984)2-(3-piperidinyl)- I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (985)2-(3-piperidinyl)- I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (986)2-(3-piperidinyl)- I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (987)2-(4-piperidinyl)-I H-benzimidazole-4-(N-N'-piperidinyl)amide (988)2-(4-piperidinyl)- I H-benzimidazole-4-(N-2-piperazinyl))amide (989)2-(4-piperidinyl)- I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (990)2-(4-piperidinyl)- I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (991)2-(4-piperidinyl)-I H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (992)2-(4-piperidinyl)-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (993)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (994)2-(4-piperidinyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (995)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide (996)2-(4-piperidinyl)-1 H-benzim idazole-4-(N' -ethyl-N-piperazinyl)amide (997)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (998)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (999)2-(4-piperidinyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (I000)2-(4-piperidinyl)-1 H-benzim idazole-4-(N-5-pyrimidinyl)am ide (1001)2-(4-piperidinyl)-1 H-benzim idazole-4-(N-2-pyridyl)am ide (I 002)2-(4-piperidinyl)- I H-benzimidazole-4-(N-3-pyridyl)amide (I003)2-(4-piperidinyl)-I H-benzimidazole-4-(N-4-pyridyl)amide (1004)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1005)2-(4-piperidinyl)-1 H-benzim idazole-4-(N-5-thiazolyl)amide (1006)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1007)2-(4-piperidinyl)-l H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (1008)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1009)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (10 1 0)2-(3-indolyl)- I H-benzimidazole-4-(N-N'-piperidinyl)amide (1011)2-(3-indolyl)-1 H-benzimidazole-4-(N-2-piperazinyl))amide (1012)2-(3-indolyl)-1 H-benzimidazole-4-(N-2'-benzim idazolyl)amide (10 1 3)2-(3-indolyl)- I H-benzim idazole-4-(N-5-benzim idazolonyl)am ide (1014)2-(3-indolyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)am ide (10 1 5)2-(3-indolyl)- I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (10 1 6)2-(3-indolyl)- I H-benzimidazole-4-(N-2-imidazolyl)amide (1017)2-(3-indolyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide (10 1 8)2-(3-indolyl} 1 H-benzim idazole-4-(N-(N'-piperazi nyl))am ide (10 1 9)2-(3-indolyl)- I H-benzim idazole-4-(N'-ethyl-N-piperazinyl)am ide (1020)2-(3-indolyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1021)2-(3-indolyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (1022)2-(3-indolyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (1023)2-(3-indolyl)-l H-benzimidazole-4-(N-5-pyrimidinyl)amide (1024)2-(3-indolyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide (1025)2-(3-indolyl)-1 H-benzimidazole-4-(N-3-pyridyl)amide (1026)2-(3-indolyl)-1 H-benzim idazole-4-(N-4-pyridyl)am ide (1027)2-(3-indolyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1028)2-(3-indolyl)-1 H-benzimidazole-4-(N-5-thiazolyl)amide (1029)2-(3-indolyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1030)2-(3-indolyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (1031)2-(3-indolyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1032)2-(3-indolyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1033)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-N'-piperidinyl)amide (1034)2-(2,3,4-trimethoxyphenyl)- I H-benzimidazole-4-(N-2-piperazinyl))amide (1035)2-(2,3,4-trimethoxyphenyl)-I H-benzim idazole-4-(N-2'-benzimidazolyl)amide (1036)2-(2,3,4-trimethoxyphenyl)- I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (I037)2-(2,3,4-trimethoxyphenyl)- I H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (1038)2-(2.3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (I 039)2-(2,3,4-trimethoxyphenyl)-I H-benzim idazole-4-(N-2-imidazolyl)amide (1040)2-(2,3,4-trimethoxyphenyl)-I H-benzim idazole-4-(N-4'-pyrazolyl)amide (1041)2-(2,3,4-trimethoxyphenyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))am ide (1042)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (l 043)2-(2,3,4-trimethoxyphenyl)- I H-benzim idazole-4-(N-2-pyrazinyl)am ide (1044)2-(2,3,4-trimethoxyphenyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (1045)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-4-pyrimidinyl)amide (1046)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (1047)2-(2,3,4-trimethoxyphenyl)- I H-benzim idazole-4-(N-2-pyridyl)am ide (1048)2-(2,3,4-trimethoxyphenyl)-I H-benzim idazole-4-(N-3-pyridyl)am ide (1049)2-(2.3,4-trimethoxyphenyl)-I H-benzim idazole-4-(N-4-pyridyl)am ide (I 050)2-(2.3,4-trimethoxyphenyl)-l H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1051)2-(2.3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-5-thiazolyl)amide (I052)2-(2,3.4-trimethoxyphenyl)-I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1053)2-(2,3.4-trimethoxyphenyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (1054)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1055)2-(2,3,4-trimethoxyphenyl)- I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (I 056)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzim idazol e-4-(N-N' -piperidinyl)am ide (1057)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzim idazole-4-(N-2-piperazinyl))amide (105 8)2-(3-hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N-2'-benzim idazolyl)amide (I 059)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1060)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-4'-carbonamido-5'-im idazol yl)amide (1061)2-(3-hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (I062)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-2-imidazolyl)am ide (I063)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (1064)2-(3-hydroxyl-4-methoxtphenyl)-1 H-benzim idazole-4-(N-(N' -piperazinyl))amide (1065)2-(3-hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1066)2-(3 hydroxyl-4-methoxyphenyl)-IH-benzimidazole-4-(N-2-pyrazinyl)amide (I067)2-(3-hydroxyl-4-methoxyphenyl)- I H-benzim idazole-4-(N-2-pyrim idinyl)am ide (1068)2-(3-hydroxyl-4-methoxyphenyl)- I H-benzim idazole-4-(N-4-pyrim idinyl)am ide (I069)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)am ide (I070)2-(3-hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide (1071)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (1072)2-(3-hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N-4-pyridyl)amide (1073)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (I 074)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-5-thiazolyl)amide (I 075)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzim idazole-4-(N-2,4-dihydroxyl-5-pyrim idin yl)amide (I 076)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidiny 1)amide (I 077)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzim idazole-4-(N-4-chloro-6-am ino-2-pyrimid inyl)amide (1078)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1079)(L)-2-(2-bromo-5-pyridine)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhy droxyethyl)]amide (I 080)(L)-2-(2-bromo-5-pyridine)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylh ydroxyethyl)]amide (1081)2-(2-bromo-5-pyridine)-1 H-benzimidazole-4-[N-(]-methyl-2-p-chlorophenylhydroxyethyl)]amide (I082)2-(2-bromo-5-pyridine)-1 H-benzimidazole-4-(N-N' -piperid inyl)am ide (1083)2-(2-bromo-5-pyridine)-1 H-benzimidazole-4-(N-2-piperazinyl))amide (1084)2-(2-bromo-5-pyridine)- I H-benzimidazole-4-(N-2'-benzim idazolyl)amide (I085)2-(2-bromo-5-pyridine)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (I 086)2-(2-bromo-5-pyridine)-1 H-benzimidazole-4-(N-o-aminophenyl)amide (1087)2-(2-bromo-5-pyridine)- I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1088)2-(2-bromo-5-pyridine)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (1089)2-(2-bromo-5-pyridine)-I H-benzim idazole-4-(N-4' -carboxyl-5' -imidazolyl)am ide (l 090)2-(2-bromo-5-pyridine)-1 H-benzim idazole-4-(N-2-im idazolyl)am ide (1091)2-(2-bromo-5-pyridine)-I H-benzim idazole-4-(N-4' -pyrazolyl)amide (I092)2-(2-bromo-5-pyridine)-1 H-benzimidazole-4-(N-(N'-piperazinyl))am ide (I 093)2-(2-bromo-5-pyridine)- I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)am ide (I 094)2-(2-bromo-5-pyridine)- I H-benzim idazole-4-(N-2-pyrazinyl)am ide (1095)2-(2-bromo-5-pyridine)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (1096)2-(2-bromo-5-pyridine)-I H-benzim idazole-4-(N-4-pyrim id inyl)am ide (1097)2-(2-bromo-5-pyridine)-I H-benzim idazole-4-(N-5-pyrimidinyl)am ide (1098)2-(2-bromo-5-pyridine)-I H-benzimidazole-4-(N-2-pyridyl)amide (1099)2-(2-bromo-5-pyridine)- I H-benzim idazole-4-(N-3-pyridyl)amide (1100)2-(2-bromo-5-pyridine)-I H-benzim idazole-4-(N-4-pyridyl)amide (110 1)2-(2-bromo-5-pyridine)- I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (I 102)2-(2-bromo-5-pyridine)-I H-benzimidazole-4-(N-5-thiazolyl)amide (I103)2-(2-bromo-5-pyridine)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (l 104)2-(2-bromo-5-pyridine)-1 H-benzimidazole-4-(N-4,6-di(2-bromo-5-pyridine)-2-pyrimi dinyl)amide (l 105)2-(2-bromo-5-pyridine)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (I106)2-(2-bromo-5-pyridine)- I H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)am ide (I 107)(L)-2-(2-amino-3-pyridine)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhy droxyethyl)]amide (1108)(L)-2-(2-amino-3-pyridine)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylh ydroxyethyl)]amide (I 109)242-amino-3-pyridine} 1 H-benzimidazole4-[N-(1-methyl-2-p-chlomphenylhydroxyethyl)]amide (I 110)2-(2-amino-3-pyridine)- I H-benzim idazole-4-(N-N'-piperidinyl)amide (1 l 11)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-2-piperazinyl))am ide (I 1 12)2-(2-amino-3-pyridine)- I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (11 13)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1114)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-o-aminophenyl)amide (II l 5)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (I 116)2-(2-amino-3-pyridine)-I H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (11 17)2-(2-amino-3-pyridine)- I H-benzim idazole-4-(N-4'-carboxyl-5'-im idazolyl)amide (1118)2-(2-amino-3-pyridine)- I H-benzimidazole-4-(N-2-imidazolyl)am ide (1119)2-(2-amino-3-pyridine)- I H-benzimidazole-4-(N-4'-pyrazolyl)am ide (1120)2-(2-amino-3-pyridine)- I H-benzim idazole-4-(N-(N'-piperazinyl))am ide (l 121)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (I122)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1123)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (1124)2-(2-amino-3-pyridine)-1 H-benzim idazole-4-(N-4-pyrimidinyl)amide (1125)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (1126)2-(2-amino-3-pyridine)-l H-benzimidazole-4-(N-2-pyridyl)amide (I 127)2-(2-amino-3-pyridine)- I H-benzimidazole-4-(N-3-pyridyl)amide (1128)2-(2-amino-3-pyridine)-1 H-benzim idazole-4-(N-4-pyridyl)am ide (l 129)2-(2-amino-3-pyridine)-I H-benzimidazole-4-(N-4-methyl -5-thiazolyl)amide (1130)2-(2-amino-3-pyridine)-1 H-benzim idazole-4-(N-5-th iazolyl)amide (1131)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1132)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-4,6-di(2-amino-3-pyridine)-2-pyrimid inyl)amide (1133)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (I 134)2-(2-amino-3-pyridine)-l H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1135)(L)-2-(2-pyrrol idine- I -yl-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (1136)(L)-2-(2-pyrrolidine- I -yl-5-pyrim idinyl)-l H-benzimidazole-4-[N-(I-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (1137)2{2-pyrrolidine-I -yl-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chloropheny Ihydroxyethyl)]amide (1138)2-(2-pyrrolidine-l - yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-N'-piperidinyl)amide (1139)2-(2-pyrrolidine-l - yl-5-pyrimidinyl)- l H-benzimidazole-4-(N-2-piperazinyl)amide (I 140)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1141)2-(2-pyrrolidine-l- yI-5-pyrimidinyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1142)2-(2-pyrrolidine-l - yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide (1143)2-(2-pyrrolidine- l -yl-5-pyrimidinyl)- l H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1144)2-(2-pyrrolidine-l-yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-4'-carbonamido-5'-imida zolyl)amide (1145)2-(2-pyrrolidine-l -yl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-'-carboxyl-5'-imidazolyl)amide (1146)2-(2-pyrrolidine-l - yl-5-pyrimidinyl)-l H-benzimidazole-4-(N-2-imidazolyl)amide (1147)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (1148)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide (1 1 49)2-(2-pyrrolidine-l-yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (I 150)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-pyrazinyl)amide (1151)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1152)2-(2-pyrrolidine-l - yl-5-pyrimidinyl)- I H-benzimidazole-4-(N-4-pyrimidinyl)amide (1153)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (I154)2-(2-pyrrolidine-l - yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-pyridyl)amide (1155)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (l 156)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)- I H-benzimidazole-4-(N-5-pyridyl)amide (1157)2-(2-pyrrolidine-l -yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1158)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-l H-benzimidazole-4-(N-5-thiazolyl)amide (1159)2-(2-pyrrolidine-I -yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimid inyl)amide (1160)2-(2-pyrrolidine-1 -yl-5-pyrimidinyl)-I H-benzim idazole-4-(N-4,6-di(2-pyrrolid ine- I -yl-5-pyrimidinyl)-2-pyrimidinyl)amide (1161)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyri midinyl)amide (1162)2-(2-pyrrolidine-l-yl-5-pyrimidinyl)-I H-benzim idazole-4-(N-4,6-dichloro-5-pyrimidin yl)amide (1163)(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-n itrophenylhydroxyethyl)jamide (1164)(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-ami nophenylhydroxyethyl)]amide (1165)2-(2-piperidine-l -yl-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhy droxyethyl)]amide (1166)2-(2-piperidine-1-yl-5-pyrimidinyl)-1 H-benzim idazole-4-(N-N'-piperidinyl)am ide (1167)2-(2-piperidine-I - yl-5-pyrimidinyl)- I H-benzimidazole-4-(N-2-piperazinyl)amide (1168)2-(2-piperidine-l - yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)am ide (1169)2-(2-piperidine-l - yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1170)2-(2-piperidine-1- yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide (1171)2-(2-piperidine-l-yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-5-benzimidazolonyl)am ide (I 172)2-(2-piperidine-1-yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidaz olyl)amide (1173)2-(2-piperidine-l -yl-5-pyrimidinyl} I H-benzimidazole-4-(N4'-carboxyl-5'-imidazolyl)amide (1174)2-(2-piperidine-l- yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (1175)2-(2-piperidine-l- yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (1176)2-(2-piperidine-l- yl -5-pyrimidinyl)-I H-benzimidazole-4-(N-(N'-piperazinyl))amide (1177)2-(2-piperidine-1-yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1178)2-(2-piperidine-1- yl-5-pyrimidinyl)-l H-benzimidazole-4-(N-2-pyrazinyl)amide (1179)2-(2-piperidine-1- yl-5-pyrimidinyl)-l H-benzimidazole-4-(N-2-pyrimidinyl)amide (1180)2-(2-piperidine-1- yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1181)2-(2-piperidine-1- yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (1182)2-(2-piperidine-1- yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-pyridyl)amide (1183)2-(2-piperidine-1- yl-5-pyrimidinyl)-l H-benzimidazole-4-(N-3-pyridyl)amide (1184)2-(2-piperidine-1- yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-4-pyridyl)amide (1185)2-(2-piperidine-l-yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1186)2-(2-piperidine-1- yl-5-pyrimidinyl)-1 H-benzim idazole-4-(5-th iazolyl)am ide (1187)2-(2-piperidine-1-yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidi nyl)amide (1188)2-(2-piperidine-1-yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4,6-di(2-piperidine-1-y1-5-pyrimidinyl)-2-pyrimidinyl)amide (1189)2-(2-piperidine-1-yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrim idinyl)amide (I 190)2-(2-piperidine-1-yl-5-pyrimidinyl)-I H-benzimidazole4-(N-,6-dichloro-5-pyrimidinyl)amide (1191)(L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (1192)(L)-2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-[N-(l -hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (1193)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide (1 1 94)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-N'-piperidinyl)amide (1195)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-piperazinyl)am ide (1196)2-(2-cyclopropylamino-5-pyrimidinyl)-l H-benzimidazole-4-(N-2'-benzimidazolyl)am ide (1197)2-(2-cyclopropylam ino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1198)2-(2-cyclopropylamino-5-pyrimidinyl)- I H-benzim idazole-4-(N-o-aminophenyl)am ide (I 199)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1200)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-4'-carbonamido-5'-imi dazolyl)amide (1201)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-4'-carboxyl-5'-imidazo lyl)amide (1202)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (1203)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide (1204)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide (1205)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1206)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1207)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (1208)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4-pyrim idinyl)amide (1209)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (1210)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-pyridyl)amide (1211)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-3-pyridyl)amide (1212)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4-pyridyl)amide (1213)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1214)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(5-thiazolyl)amide (1215)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrim idinyl)amide (1216)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-4,6-di(2-cyclopropylam ino-5-pyrimidinyl)-2-pyrimidinyl)amide (1217)2-(2-cyclopropylamino-5-pyrimidinyl)- I H-benzim idazole-4-(N-4-chloro-6-am ino-2-py rimidinyl)amide (1218)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidi nyl)amide (1219)(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (1220)(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-[N-(I -hydroxymethyl-2-p-a minophenylhydroxyethyl)]amide (1221)2-(I ,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide (1222)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-N'-piperidinyl)am ide (1223)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-(N-2-piperazinyl)amide (1224)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1225)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- I H-benzimidazole-4-(N-o-hydroxyphenyl)am ide (I 226)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-o-aminophenyl)am ide (I 227)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-(N-5-benzimidazolonyl)amide (I 228)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-4'-carbonam ido-5' -i m id azolyl)amide (1229)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzim idazole-4-(N-4'-carboxyl-5'-im idazol yl)amide (I230)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-2-imidazolyl)am ide (1231)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- I H-benzim idazole-4-(N-4'-pyrazolyl)ami de (1232)2-(l,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))am ide (1233)2-(I ,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1234)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- I H-benzim idazole-4-(N-2-pyrazinyl)amide (1235)2-(l,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-(N-2-pyrimidinyl)amide (1236)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1237)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-(N-5-pyrimidinyl)amide (1238)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-(N-2-pyridyl)amide (I239)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-(N-3-pyridyl)am ide (I 240)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-4-pyridyl)amide (1241)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1242)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(5-thiazolyl)amide (1243)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- I H-benzi midazole-4-(N-2,4-dihydroxyl-5-pyrim idinyl)amide (1244)2-(l,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimi dinyl)amide (1245)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzim idazole-4-(N-4-chloro-6-amino-2-pyr imidinyl)amide (1246)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrim idi nyl)amide (1247)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)am ide (1248)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (I 249)2-(4-methoxypyridyl)- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1250)2-(5-amino-2-thienyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrim idinyl)am ide (1251)2-(5-amino-2-thienyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1252)2-(5-amino-2-thienyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (I 253)2-(6-methoxypyridyl)- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)am ide (I 254)2-(6-methoxypyridyl)- I H-benzim idazole-4-(N-6-purinyl)amide (1255)2-(6-methoxypyridyl)- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)am ide (1256)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4{N-2-hydroxyl-4-pyrimidinyl)amide (1257)2-(4-dimethylam inopyridyl)- I H-benzimidazole-4-(N-6-purinyl)amide (125 8)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1259)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1260)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1261)2-(3-pyridazinyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1262)2-(2-N-methyl -4-N-methylpiperazinyl)-I H-benzim idazole-4-(N-2-hydroxyl-4-pyrim idinyl)amide (1263)2-(2-N-methyl-4-N-methylpiperazinyl)-I H-benzim idazole-4-(N-6-purinyl)amide (1264)2{2-N-methyl-4-N-methylpiperazinyl)-1 H-benzim idazole-4-(N-6-hydroxyl-2-purinyl)am ide (1265)2-(2-pyrazinyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrim idinyl)am ide (1266)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-6-purinyl)am ide (1267)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1268)2-N-piperazinyl-I H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1269)2-N-piperazinyl-1 H-benzimidazole-4-(N-6-purinyl)amide (I 270)2-N-piperazinyl- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)am ide (1271)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1272)2-(4-methyl-5-aminothiazolyl)-I H-benzim idazole-4-(N-6-purinyl)am ide (1273)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)am ide (1274)2-thiazolyl-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)am ide (1275)2-thiazolyl l-1 H-benzimidazole-4-(N-6-purinyl)amide (1276)2-thiazolyl-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1277)5-thiazolyl- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (I 278)5-thiazolyl- I H-benzim idazole-4-(N-6-purinyl)amide (I 279)5-thiazolyl-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (I 280)2-(2-pyrimidinyl)- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1281)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1282)2-(2-pyrimidinyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (I283)2-(2-phenyl-5-pyrimidinyl)- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1284)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (I 285)2-(2-phenyl-5-pyrimidinyl)- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1286)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1287)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1288)2-(4-amino-6-chloro-5-pyrimidinyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1289)2-(2-pyrrolyl)- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)am ide (1290)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1291)2-(2-pyrrolyl)- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1292)2-(N-methyl -2-pyrrolyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1293)2-(N-methyl-2-pyrrolyl)- I H-benzimidazole-4-(N-6-purinyl)amide (1294)2-(N-methyl-2-pyrrolyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1295)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1296)2-(3,5-dim ethyl -2-pyrrolyl)- I H-benzim idazole-4-(N-6-purinyl)amide (1297)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzim idazole-4-(N-6-hydroxyl-2-purinyl)amide (1298)2-(2-quinolinyl)-]H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1299)2-(2-quinolinyl)-l H-benzimidazole-4-(N-6-purinyl)amide (1300)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1301)2-(3-quinolinyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1302)2-(3-quinolinyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1303)2-(3-qu inol i nyl)-1 H-benzim idazole-4-(N-6-hydroxyl-2-purinyl )amide (1304)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1305)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1306)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1307)2-(3-piperidinyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1308)2-(3-piperidinyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1309)2-(3-piperidinyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (I 310)2-(4-piperidinyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1311)2-(4-piperidinyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1312)2-(4-piperidinyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1313)2-(3-indolyl)-1 H-benzim idazole-4-(N-2-hydroxyl-4-pyrimidinyl)am ide (1314)2-(3-indolyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1315)2-(3-indolyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1316)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1317)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1318)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1319)2-(3-hydroxyl-4-methoxyphenyl)-l H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (I 320)2-(3-hydroxyl-4-methoxyphenyl)-IH-benzimidazole-4-(N-6-purinyl)amide (l 321)2-(3-hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1322)2-methoxy- I H-benzim idazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1323)2-methoxy-I H-benzimidazole-4-(N-6-purinyl)amide (1324)2-methoxy-I H-benzim idazole-4-(N-6-hydroxyl-2-purinyl)am ide (I325)2-ethoxy-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1326)2-ethoxy- I H-benzimidazole-4-(N-6-purinyl)amide (1327)2-ethoxy-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1328)2-(2,6-dimethyl-2,6-octadienyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1329)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1330)2-(2,6-dimethyl-2,6-octadienyl) -1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1331)2-pyrazolyl-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1332)2- pyrazolyl -1H-benzimidazole-4-(N-6-purinyl)amide (1333)2- pyrazolyl -1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (I 334)2-(2'-pyridyl)- I H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (I 335)2-(2'-pyridyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1336)2-(2'-pyridyl)- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1337)2-(3'-pyridyl)- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1338)2-(3"-pyridyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1339)2-(3'-pyridyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (I 340)2-(4'-pyridyl)- l H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1341)2-(4'-pyridyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1342)2-(4'-pyridyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1343)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1344)2-(2'-imidazolyl)-1 H-benzimidazole-4-(N-6-purinyl)am ide (1345)2-(2'-imidazolyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (I 346)2-(4-methoxypyridyl)- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1347)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-6-purinyl)amide (I 348)2-(4-methoxypyridyl)- I H-benzim idazo le-4-(N-6-hydroxyl-2-purinyl)am ide (1349)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1350)2-(4-dimethylaminopyridyl)-I H-benzimidazole-4-(N-6-purinyl)amide;

(I 351)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1352)2-(3-pyridazinyl)- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1353)2-(3-pyridazinyl)- I H-benzim idazole-4-(N-6-purinyl)amide (1354)2-(3-pyridazinyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1355)2-(2-N-methyl-4-N-methylpiperazinyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrim idinyl)amide (I 356)2-(2-N-methyl-4-N-methylpiperazinyl)- I H-benzimidazole-4-(N-6-purinyl)amide (1357)2-(2 N-methyl-4-N-methylpiperazinyl)-IH-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1358)2-(2-pyrazinyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1359)2-(2-pyrazinyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1360)2-(2-pyrazinyl)- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1361)2-(4-methyl-5-aminothiazolyl)- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1362)2-(4-methyl-5-am inothiazolyl)- I H-benzimidazole-4-(N-6-purinyl)am ide (1363)2-(4-methyl-5-aminothiazolyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1364)2-(2-thiazolyl)- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (I 365)2-(2-thiazolyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1366)2-(2-thiazolyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1367)2-(5-thiazolyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1368)2-(5-thiazolyl)-1 H-benzim idazole-4-(N-6-purinyl)amide (1369)2-(5-thiazolyl)- I H-benzim idazole-4-(N-6-hydroxyl-2-purinyl)amide (1370)2-(2-pyridyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1371)2-(2-pyridyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1372)2-(2-pyridyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (13 73 )2-(2-phenyl-5-pyrim idinyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1374)2-(2-phenyl-5-pyrimidinyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1375)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1376)2-(4-amino-6-chloro-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (I 3 77)2-(4-am i no-6-chloro-5 -pyrimid inyl)- I H-benzim idazole-4-(N-6-puri nyl)am ide (1378)2-(4-amino-6-chloro-5-pyrimidinyl)- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1379)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (13 80)2-(2-pyrrolyl)-1 H-benzim idazole-4-(N-6-purinyl)am ide (1381)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1382)2-(N-methyl-2-pyrrolyl)-1 H-benzim idazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1383)2-(N-methyl-2-pyrrolyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (13 84)2-(N -m ethyl -2-pyrrolyl)- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1385)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1386)2-(3,5-dimethyl-2-pyrrolyl)-I H-benzimidazole-4-(N-6-purinyl)amide (13 87)2-(3, 5-dimethyl-2-pyrrolyl)-1 H-benzim idazole-4-(N-6-hydroxyl-2-purinyl)am ide (1388)2-(2-quinolinyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1389)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1390)2-(2-quinolinyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (I 391)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1392)2-(2-piperidinyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1393)2-(2-piperidinyl)- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1394)2-(4-piperidinyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1395)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1396)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1397)2-(3-indolyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (I 398)2-(3-indolyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1399)2-(3-indolyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (I 400)2-(2,3,4-trimethoxyphenyl)- I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1401)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1402)2-(2,3,4-trimethoxyphenyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1403)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1404)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1405)2-(3-hydroxyl-4-methoxyphenyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1406)2-(2-bromo-5-pyridine)-l H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1407)2-(2-bromo-5-pyridine)-I H-benzimidazole-4- (N-6-purinyl)amide (1408)2-(2-bromo-5-pyridine)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1409)2-(2-amino-3-pyridine)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1410)2-(2-amino-3-pyridine)-1 H-benzimidazole-4-(N-6-purinyl)amide (1411)2-(2-amino-3-pyridine)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1412)2-(2-pyrrolidine- I -yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1413)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-IH-benzimidazole-4-(N-6-purinyl)amide (1414)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1415)2-(2-piperidine-l-yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidin yl)amide (1416)2-(2-piperidine-l - yl-5-pyrimidinyl)-I H-benzimidazole-4-(N-6-purinyl)amide (1417)2-(2-piperidine-l -yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1418)2-(2-cyclopropylam ino)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1419)2-(2-cycloprop) lam ino-5-pyrimidinyl)- I H-benzimidazole-4-(N-6-purinyl)amide (1420)2-(2-cyclopropylamino-5-pyrimidinyl)-I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1421)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimi dinyl)amide (I422)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-6-purinyl)amide (1423)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- I H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1424)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide.

Preferably, the pharmaceutically acceptable salts of benzimidazole-4-carboxamide derivatives are inorganic acid salts thereof selected from sulfate, hydrochloride, nitrate, phosphate or boratethe, or organic acid salts thereof selected from citrate, succinate, tartrate, lactate or mesylate.

Another purpose of the present invention is to provide anti-cosxackie-viruses pharmaceutical compositions. The pharmaceutical compositions comprise a therapeutically effective amount of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to any one of claims 1 - 7, and one or more pharmaceutically acceptable thinner, excipient and/ or inert carrier.

A further purpose of the present invention is to provide uses of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts for for preparation of antivirus medications, wherein the viruses are CoxsackieVirus, echovirus and enterovirus which belong to picornaviridae.

Another purpose of the prevent invention is to provide a method of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof as shown in Formula (1), comprising the following steps:

(1) 2-aminoacetyl-3-nitrobenzoic acid is undergoing reactions of ammonolysis, Hoffman degradation and reduction in turn, to produce 2,3- diamino benzoic acid.

(2) 2,3-diamino benzoic acid is condensed with aldehydes X-CHO in the presence of catalyst of cupric acetate, to produce benzimidazole-4-carboxylic acid of Formula (II).

OH
O

/ N\
X
N (II) (3) benzimidazole-4-carboxylic acid is reacted with thionyl chloride to produce acyl chloride, and then condensing the acyl chloride and an amine NH2-Y, to produce the benzimidazole-4-carboxamide derivative of Formula (1).

Y
N-H

NN1( (I) The above reaction conditions are as follows: benzimidazole-4-carboxylic acid is reated with thionyl chloride at temperature of 0-80 C in a molar molecular ratio of thionyl chloride to benzimidazole-4-carboxylic acid is 1-20 times, to produce benzimidazole-4-carbonyl chloride, and then benzimidazole-4-carbonyl chloride is reacted with an amine in an organic solvent at temperature of 0100 C to produce benzimidazole-4-carboxamide derivatives. Wherein the organic solvent comprises dichloroethane, 1,1,2-trichloroethane, chloroform, tetrachloroethylene, benzene, toluene, xylene, chlorobenzene or dichlorobenzene, and so on.

The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof of the present invention may be administered orally or not. The dosage varies with different drugs, the dosage is 10-300 mg per day in general conditions.

BRIEF DESCRIPTION OF THE DRAWINGS

Fig. I shows 'HNMR spectrogram of 2-(2,3,4-trihydroxyphenyl)-IH- benzimidazole -4-carboxylic acid in Example 9.

Fig. 2 shows 'HNMR spectrogram of 2-(5-nitro-2-thienyl)-]H-benzimidazole-4 -(N-(I -hydroxymethyl-2-p-nitrophenylhydroxyethyl))amide in Example 21.

Fig. 3 shows 'HNMR spectrogram of 2-(5-nitro-2-thienyl)-IH-benzimidazole -4-(N-o-fluorophenyl)amide in Example 28.

Fig. 4 shows 'HNMR spectrogram of (L)-2-(2-pyridyl)-1H-benzimidazole-4-(N-(1-hydroxym ethyl-2-p-nitrophenylhydroxyethyl)amide in Example 194.

Fig. 5 shows IHNMR spectrogram of 2-(4-hydroxyphenyl)-1H- benzimidazole-4-(N-o-fluorophenyl)amide in Example 663.

Fig. 6 shows 1HNMR spectrogram of (L)-2-(3-hydroxyphenyl)-1H-benzimidazole -4-(N- (I -hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide in Example 664.

DETAILED DESCRIPTION OF THE PRESENT INVENTION AND
PREFERRED EMBODIMENTS THEREOF

Hereafter, the present invention will be described specifically with reference to examples. The examples are given only for illustration of the technical solution of the present invention and should not be construed to limit the present invention.

The method of preparing for benzimidazole-4-amide derivatives of the present invention is as follows: using 2-aminoacetyl-3-nitrobenzoic acid as an initiating raw material, 2-aminoacetyl-3-nitrobenzoic acid in turn is undergoing ammonolysis, Hoffman degradation and reduction, to produce 2,3- diamino benzoic acid; and then condensing 2,3-diamino benzoic acid and aldehydes X-CHO in the presence of catalyst of cupric acetate, to produce benzimidazole-4-carboxylic acid; and then reacting benzimidazole-4-carboxylic acid with thionyl chloride to produce acyl chloride, and then condensing the acyl chloride and an amine NH2-Y, to produce the benzimidazole-4-carboxamide derivative.

Example 1: Synthesis of 2.3-diamino benzoic acd Step 1: Synthesis of 2-aminoacetyl-3-nitrobenzoic acid 30g of 3-nitro phthalic anhydride is added into 45ml of concentrated ammonia with 28g/g% concentration; and heat it to 60 C under stirring for 30 minutes; and then to cool it to 10 C till precipitate needle shape crystals; and to acidize the needle shape crystals with concentrated chlorhydric acid to produce white solids; and then to filter and dry it to obtain 29.4g of 2-aminoacetyl-3-nitrobenzoic acid.

Step 2: Synthesis of 2-amino-3-nitrobenzoic acid 13.9g of bromine is dropped into 100ml of sodium hydroxide aqueous-solution containing 7.3g of sodium hydroxide to a solution. Then 17 g of 2-aminoacetyl-nitrobenzoic acid is added into the above solution; and to heat it to 80 C to precipitate a large amount of red solids; to fluter and then acidize it with the concentrated chlorhydric acid to produce yellow solid products; to dry it to obtain 13.7g of 2-amino-3-nitrobenzoic acid; and then recrystallize the yellow solid products by adding hot water to obtain the yellow needle shape crystals.

Step 3: Synthesis of 2,3-diaminobenzoic acid 3g of the above mentioned 2-amino-3-nitrobenzoic acid is added into 30m1 of methanol, 20% sodium hydroxide aqueous solution with the same molar as 2-amino-3-nitrobenzoic acid is dropped into the above methanol solution till dissolv e completely. 0.2g of Raney nickel at the moment is added in to the methanol solution, and to heat it to 65 C and reflux it at the temperature; and then drop 80g/g%
hydrazine hydrate (about 1.5 equivalent weight x 1.1) till the yellow disappears completely. Hot Raney nickel is filtered; and then heat and concentrate the mother liquid and acidize it with the concentrated chlorhydric acid to produce 2.3g of red 2,3-diaminobenzoic acid;
afterwards isolate and purify the crude product of red 2,3-diaminobenzoic acid by column chromatography .

Example 2: Synthesis of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4- carboxylic acid 2.Og of 2,3-diaminobenzoic acid is dissolved into 60m1 of methanol, and methanol solution of 5-nitrofurfural is added into the methanol under stirring. Then 0.5g of cupric acetate (Cu(Ac)2=H20) is added into the above methanol, and then to heat and reflux it; and then to filter hot solution after 2,3-diaminobenzoic acid disappears. 20%
sodium sulfide aqueous solution is added into the filtrate and heat it till boiling; and then filtrate the copper sulfide deposition while it is hot; and then to evaporate the filtrate to dry, purify it through column chromatography to obtain 2-(5-nitro-2-thienyl)-IH-benzimidazole-4-carboxylic acid. The yield is about 65%.

Examples 3-20: synthesis of intermediates of benzimidazole-4- carboxylic acid Synthesize the benzimidazole-4- carboxylic acid as shown in Formula (II) according to the method of Example 2. The difference is to use aldehydes with different X
group as listed in Table 1.

OH
O

N~- X

N (II) Table 1 No. of Products Compounds X Yield%
4 2-(2-pyrimidinyl)-I H-benzimidazole-4-ca CN 75 rboxylic acid N

2-(2-thienyl)-1H-benzimidazole-4- S 76 carboxylic acid 6 2-methyl-I H-benzimidazole-4- -CH3 72 carboxylic acid 7 2-phenyl-IH-benzimidazole-4- 80 carboxylic acid 8 2-(4-(dimethylamino)-phenyl)-I H- 75 benzimidazole-4-carboxylic acid CH3 N_ CH3 9 2-(2.3,4-trihydroxyphenyl)-I H- gCH

benzimidazole-4-carboxylic acid 10 2-(4-methoxy-2-pyridyl)-I H- N 68 benzimidazole-4-carboxylic acid cj~

11 2-(6-methoxy-2-pyridyl)-1H- &N 70 benzimidazole-4-carboxylic acid OCH3 12 2-(4-(dimethylamino)-2-pyridyl)-1H- N 75 benzimidazole-4-carboxylic acid N\
CH3" CH3 13 2-(3-pyridazinyl)-1 H- benzimidazole 60 -4-carboxylic acid 14 2-(2-piperazinyl)-I H- benzimidazole CNJ 61 N
-4-carboxylic acid 15 2-(5-amino-4-methyl-2-thiazolyl)-I H- CH3 70 benzimidazole-4-carboxylic acid N}i, 16 2-(3-quinolinyl)-1 H- benzimidazole I 63 -4-carboxylic acid N /

17 2-(2-pyrrolyl)-I H- benzimidazole N J 75 -4-carboxylic acid 18 2-(3-indolyl)-1 H- benzimidazole NH 71 F/_\
-4-carboxylic acid 19 2-(2-piperidinyl)-IH- benzimidazole N 68 -4-carboxylic acid 20 2-(2-quinolinyl)-1H- benzimidazole I 70 -4-carboxylic acid N ) Structure Identification of Products:
(4) 2-(2-pyrimidinyl)-1H-benzimidazole-4-carboxylic acid 'HNMR (DMSO, 400MHz) b: 7.43-7.45(t, ] H), 7.67-7.80(t, I H), 7.90-7.91(d, l H), 7.93-7.94(d, I H), 9.08-9.09(d, I H), 9.10-9.12(d, I H);

(5) 2-(2-thienyl)-1H-benzimidazole-4-carboxylic acid ' HN MR (DMSO, 400MHz) S: 7.15-7.1 8(t, l H), 7.41 -7.45(t, l H), 7.68-7.70(d, l H), 7.85(d,I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(6) 2-methyl-1H-benzimidazole-4-carboxylic acid ' HNMR (DMSO, 400MHz) 6: 2.51(s,3H), 7.41 -7.45(t, l H), 7.89-7.91(d,1 H), 7.93-7.94(d, l H);

(7) 2-phenyl-1H-benzimidazole-4-carboxylic acid 'HNMR (DMSO, 400MHz) 6: 7.41-7.45(t,IH), 7.38-7.42(t,IH) 7.50-7.53(t,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.28-8.30(d,2H);

(8) 2-(4-(dimethylamino)-phenyl)-1H-benzimidazole-4-carboxylic acid 'HNMR (DMSO, 400MHz) 6: 3.06(s,6H) 6.82-6.84(d,2H), 7.41-7.45(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 7.97-7.99(d,2H);

(9) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-carboxylic acid (refer to Figure 1) 'HNMR (DMSO, 400MHz) 6: 6.43-6.46 (d, IH), 7.28-7.32 (t, IH), 7.77-7.79 (d, IH), 7.82-7.85 (m, l H), 8.5 7(s, I H), 9.54 (s, 1 H), 12.11(s, I H), 13.16(s, 1 H);

(10) 2-(4-( methoxy)-2-pyridyl)-1H-benzimidazole-4-carboxylic acid 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,1H), 7.41-7.45(t,IH), 7.59-7.6 1(d, I H), 7.89-7.9 1(d, l H), 7.93-7.94(d,1 H), 8.48-8.49(d, l H);

(11) 2-(6-methoxy-2-pyridyl)-IH-benzimidazole-4-carboxylic acid 'HNMR (DMSO, 400MHz) 6: 3.80(s,3H), 6.50-6.51(d,IH), 7.38-7.39(d,IH), 7.41 -7.45(t, l H), 7.72-7.75(t,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H);

(12) 2-(4-(dimethylamino)-2-pyridyl)-1H-benzimidazole-4-carboxylic acid ' HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 7.16-7.18(d, I H), 7.41-7.45(t, I H), 7.71 (s, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.05-8.07(d, I H);

(13) 2-(3-pyridazinyl)-1H-benzimidazole-4-carboxylic acid 'HNMR (DMSO, 400MHz) 6: 7.41-7.45(t, I H), 7.61-7.63(t, l H), 7.89-7.91(d, l H), 7.93-7.94(d,1 H), 8.06-8.08(d, I H), 9.34-9.37(d, I H)--(14) 2-(2-piperazinyl)-IH-benzimidazole-4-carboxylic acid 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,2H), 2.60-2.62(m,IH), 2.65-2.66(m,1H), 2.67-2.70(m, l H), 2.72-2.75(m, l H), 2.84-2.88(m, l H), 3.09-3. 14(m, l H), 4.14-4.19(m,1 H), 7.41-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(15) 2-(5-amino-4-methyl-2-thiazolyl)-1H-benzimidazole-4-carboxylic acid 'HNMR (DMSO. 400MHz) 6: 1.03-1.09(d,3H), 3.70-3.73(m, l H), 4.17-4.22(m, l H), 5.11-5.13(d,2H), 7.41-7.45(t,I H), 7.89-7.91(d,1 H), 7.93-7.94(d,1 H);

(16) 2-(3-quinolinyl)-1H-benzimidazole-4-carboxylic acid ' HNMR (DMSO, 400MHz) 6: 7.41-7.45(t, l H), 7.60-7.65(t, I H), 7.78-7.80(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 7.97-7.99(d, I H), 8.06-8.09(d, l H), 8.22(s, I H), 8.57(s, I H);

(17) 2-(2-pyrrolyl)-1H-benzimidazole-4-carboxylic acid ' HNMR (DMSO, 400MHz) 8: 6.15-6.1 7(t, I H), 6.39-6.40(d, I H), 6.95-6.98(t,1 H), 7.41-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H);

(18) 2-(3-indolyl)-1H-benzimidazole-4-carboxylic acid ' HNMR (DMSO, 400MHz) 6: 7.01 -7.05(t, I H), 7.31 -7.34(t, I H), 7.41 -7.45(t, I H), 7.54-7.56(d,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.14-8.1 6(d, I H), 8.60(s,1 H);

(19) 2-(2-piperidinyl)-1H-benzimidazole-4-carboxylic acid 'HNMR (DMSO, 400MHz) S: 1.47-1.49(m,2H), 1.50-1.55(m,2H), 1.67-1.92(m,2H), 4.01-4.03(m,1H), 7.41-7.45(t,1H), 7.89-7.91(d,IH), 7.93-7.94(d,1H);
(20) 2-(2-quinolinyl)-1H-benzimidazole-4-carboxylic acid 'HNMR (DMSO, 400MHz) S: 1.43-1 .45(m, I H), 1.46-1.47(m,11-1), 1.49-1.51 (m, l H), I .53-1.55(m, l H), 1.67-1 .70(m, l H), 1.92-1 .96(m, l H), 2.69-2.71(m, l H), 2.78-2.80(m,1 H), 4.01-4.03(m, I H), 7.41-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H).

Example 21: Synthesis of (L)-2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-hyd roxymethyl-2-p-nitrophenylhydroxyethyl)amide 1.Og of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid in Example 2 is added into 15m1 of thionyl chloride and is reacted for 60 minutes, after end of the reaction completely, (L)-2-amino-l-p-nitrophenyl-1,3-propylene glycol (1.1eq.) is added into the reaction mixture under stirring for 2 hours at the room temperature; and then filter the inorganic salt, evaporate the solvent to dry and obtain the final product of 2-(5-nitro-2-thienyl)-l H-benzim idazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyet hyl)amide. The yield is about 93%. 'HNMR spectrum is shown in Figure 2 Structure Identification of Product:

'HNMR(DMSO,400MHz)5:3.59-3.60(m, I H),3.65-3.67(t, l H),4.16-4.22(q, I H),5.07-5.
08(t, l H),5.27-5.28(t, I H),6.16-6.17(d, I H),7.35-7.39(t, I H),7.53-7.54(d, I H),7.72-7.75(m,2H
),7.77-7.79(m,2H),8.00-8.01 (d, I H),8.05-8.07(d,3H),10.04-10.06(d,2H),14.05(s, I H).
Example 22: Synthesis of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-methyl -2-p-chlorophenylhydroxyethyl)amide 1.Og of 2-(5-nitro-2-thienyl)-IH-benzimidazole-4- carboxylic acid is added into 15m]
of thionyl chloride; and to heat and reflux it for 60 minutes. After end of the reaction, 2-amino-l-p-chlorophenyl-l-propanol (1.1eq) is dissolved into tetrahydrofuran, and then drop acyl chloride to the above tetrahydrofuran mixture under stirring at the room temperature and then filter inorganic salt, evaporate the solvent to dry, and then isolate the mixture through column chromatography to obtain 2-(5-nitro-2-thienyl)-1 H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl) amide. The yield is about 92%.

Structure Identification of Product:

'HNMR (DMSO, 400MHz) S: 1.10-1.16(d,3H), 3.26-3.28(m,IH), 3.64-3.66(d,1H), 47I -4.74(m, l H), 7.28-7.30(d,2H), 7.35-7.38(d,2H), 7.41 -7.45(t, l H), 7.56-7.58(d, I H), 7.62-7.68(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H).

Examples 23-67:

Use the same process as Example 22 to synthesize the compound as shown in Table 2.

N
NH
Table 2 No. Compounds X Y Field 2-(2-pyridyl)-1 H-benzimidazole-4-N N

-hydroxyethylamide OH
_ O
2-(2-pyridyl)-1H-benzimidazole-4-N N
24 NH \ / OH 80 -o-hydroxyphenylcarboxylamide OH F
2-(2-hydroxyphenyl)-l H-benzimida -zole-4-(N-o-fluorophenyl)amide \ /

(L)-2-(2-hydroxyphenyl)-1H-benzim OH "
H OH
26 idazole-4-[N-(l-hydroxyl-2-p-nitrop / 91 henylhydroxyethyl)]amide HO NH H

OH
2-(5-nitro-2-thienyl)-1H-benzimidaz S
ole-4-(N-6-hydroxyl-2-purinyl)amide -IN N N
H H
2-(5-nitro-2-thienyl)-1 H-benzimidaz ole-4-(N-o-fluorophenyl)amide \ /

F
29 2-(3,4,5-trihydroxyphenyl)- I H-benzi I - 93 -NH
midazole-4-(N-o-fluorophenyl)amide OH OH x OH
2-(3,4,5-trihydroxyphenyl)-1 H-benzi midazole-4-(N-hydroxyethyl)amide OH on OH
2-(2-piperidinyl)-IH-benzimidazole- CH3 31 N ) - N N 95 4-(4-N'-ethyl-N-piperazinyl)amide ~J
32 2-(2-pyridyl)-IH-benzimidazole-4-( O\,- -N N-/ CH3 94 4-N'-ethY 1-N-P i PerazinY 1)amide (L)-2-(2,6-dimethyl-2,6-octadienyl)- H H OH
33 1 H-benzimidazole-4-[N-(] -hydroxy " 90 methyl-2-p-nitrophenylhydroxyethyl )]amide HO / H H

cH, H2N
H
(L)-2-(2,6-dimethyl-2,6-octadienyl)- I H off 34 1 H-benzimidazole-4-[N-(] -hydroxy / H 89 methyl-2-p-am inophenylhydroxyeth HO NH H
yl)]amide H,C CH, CH Cl 2-(2,6-dimethyl-2,6-octadienyl)- I H- H H
35 benzimidazole-4-[N-(1-methyl-2-p-c CH3 90 hlorophenylhydroxyethyl)]amide HO NH
H,C CH3 GH, H
2-(2,6-dimethyl-2,6-octadienyl)- I H- N"-36 benzimidazole-4-(N-N'-piperidinyl) amide 17 H,C CH, H
2-(2,6-dimethyl-2,6-octadienyl)-1 H- /H"
37 benzimidazole-4-(N-2-piperazinyl)a 89 mide N
H

2-(2,6-dimethyl -2,6-octadienyl)-I H- ) H
38 benzimidazole-4-(N-2'-benzimidazo 91 Iyl)amide N
H

H
2-(2,6-dimethyl-2,6-octadienyl)-1 H- N
39 benzimidazole-4-(N-o-aminophenyl) 88 amide NHZ

2-(2,6-dimethyl-2,6-octadienyl)- I H- N
40 benzimidazole-4-(N-5- )>=O 87 benzimidazolonyl)amide H H

N
2-(2,6-dimethyl-2,6-octadienyl)-I H-41 benzimidazole-4-(N-4'-carbonamido HzN I N 90 -5'-imidazolyl)amide 17 H

2-(2,6-dimethyl-2,6-octadienyl)-I H- N
42 benzimidazole-4-(N-4'-pyrazolyl) I 87 amide NH\

2-(2,6-dimethyl-2,6-octadienyl)- I H-43 ~^\
benzimidazole-4-(N-(N'-piperazinyl N-N NH 87 ))amide 117 2-(2,6-dimethyl-2,6-octadienyl)- I H- N\
44 benzimidazole-4-(N-2-pyrazinyl) / 90 amide H N

CH
2-(2,6-d imethyl-2,6-octadienyl)- I H- N \
45 benzimidazole-4-(N-2-pyrimidinyl)a / 91 mide H N
H3C -CH, CHI
N
46 2-(2,6-dimethyl-2,6-octadienyl)-IH-b ~ 93 enzimidazole-4-(N-2-pyridyl)amide N /
H
H,c cH, CH, 2-(2,6-dimethyl-2,6-octadienyl)- I H- N cH, 47 benzimidazole-4-(N-4-methyl-5-thia 90 zolyl)amide 1 s H
H,C CH, CH22-(2,6-dimethyl-2,6-octadienyl)-I H- N- H
HO~ N~ 85 48 benzimidazole-4-(N-2,4-dihydroxyl-OH
5-pyrimidinyl)amide "3C CH, cH, OCH3 2-(2,6-dimethyl-2,6-octadienyl)-I H- N

49 benzimidazole-4-(N-4,6-dimethoxy- N-~\ 94 N
2-pyrimidinyl)amide H,C CH, C"3 CH, cI
2-(2,6-dimethyl-2,6-octadienyl)-IH- N-50 benzimidazole-4-(N-4-chloro-6-ami /N \\ / 88 N
no-2-pyrimidinyl)amide H,C CH, NH2 CH, CI
2-(2,6-dimethyl-2,6-octadienyl)- I H- N-51 benzimidazole-4-(N-4,6-dichloro-5- \\ N 90 pyrimidinyl)amide N
CI
H3C CH, CH, 2-(2,6-dimethyl-2,6-octadienyl)- I H- H
52 benzimidazole-4-(N-o-fluorophenyl) (\~ 93 amide I F
H,C CHI
CH, 2-(2,6-dimethyl-2,6-octadienyl)-I H- NH

53 benzimidazole-4-(N-2-hydroxyl-4-p N 86 yrimidinyl)amide H 3C CH
HO N

54 2-(2,6-dimethyl-2,6-octadienyl)- I H-b \ NH 90 enzimidazole-4-(N-6-purinyl)amide CH, CH
2-(2,6-dimethyl-2,6-octadienyl)-1 H-55 benzimidazole-4-(N-6-hydroxy-2-pu "~ 91 rinyl)amide _H "
H

OZN
H
56 (L)-2-(2-thienyl)-IH-benzimidazole- I / H H 90 4-[N-(I -hydroxymethyl-2-p-nitrophe \ õo NH
H
nylhydroxyethyl)]amide (L)-2-(2-thienyl)-I H-benzimidazole- s I H o,, 57 4-[N-(1-hydroxymethyl-2-p-aminop 92 henylhydroxyethyl)]amide Ho H
p 2-(2-thienyl)- I H-benzimidazole-4-[ s ( \ " H
58 N-(I-methyl-2-p-chlorophenylhydro CH3 92 xyethyl)]amide HO NH

H
2-(2-thienyl)-1 H-benzimidazole-4-( s N"'N

N-N'-piperidinyl)amide 0\/

s HN H
60 2-(2-thienyl)-]H-benzimidazole-4-( 88 N-2-piperazinyl)amide 0\/
Y"') H
s N
61 2-(2-thienyl)-IH-benzimidazole-4-( ( N--- 93 N-2'-benzimidazolyl)amide :/CN
H
H
62 2-(2-thienyl)- I H-benzimidazole-4-( I NH, 94 N-o-aminophenyl)amide NHZ
$
63 2-(2-thienyl)- I H-benzimidazole-4-( 90 N-5- benzimidazolonyl)amide \ \N / H

H
s /N
64 2-(2-thienyl)- I H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide N

H
N~
65 2-(2-thienyl)-l H-benzimidazole-4-( C / 92 N-4'-pyrazolyl)amide NH

2-(2-thienyl)-1H-benzimidazole-4-( H
66 i-N NH 94 N-(N'-piperazinyl))amide r N
$
67 N2--2(2--thienyl)-razin 1IH-benzimidazole-4-( I 94 PY Y)amide \ N N
H
S
68 2-(2-thienyl)-IH-benzimidazole-4-( II 93 N-2-pyrimidinyl)amide 0\/ N"
H

69 2-(2-thienyl)-IH-benzimidazole-4-( s NI \ 90 N-2-pyridyl)amide 0\/
N
H

2-(2-thienyl)-1 H-benzimidazole-4-( N 91 70 N-4-methyl-5-thiazolyl)amide 0\/ \ \ Ni S H
N_ 2-(2-thienyl)- I H-benzimidazole-4-( s H
71 N-2,4-dihydroxyl-5-pyrimidinyl)ami HO \ 93 de C\)/ N
OH

72 2-(2-thienyl)- I H-benzimidazole-4-(N s /N\ / 93 -4,6-dimethoxy-2-pyrimidinyl)amide N

CI
2-(2-thienyl)-1 H-benzimidazole-4-( s 73 N-4-chloro-6-amino-2-pyrimidinyl) ,N-~ 88 amide \\"

G

2-(2-thienyl)-1 H-benzimidazole-4-( s N
"
74 N-4,6-dichloro-5-pyrim idinyl)amide \\ N 89 N
CI

75 2-(2-thienyl)-1H-benzimidazole-4-( I " 87 s N-o-fluorophenyl)amide 0\/
F
$ IH
76 2-(2-thienyl)-1 H-benzimidazole-4-( 92 N-2-hydroxyl-4-pyrimidinyl)amide HO~

S IH
77 2-(2-thienyl)-1 H-benzimidazole-4-( 90 N-6-purinyl)amide \ I J
N N
OH
2-(2-thienyl)-I H-benzimidazole-4-( s 78 \\~J J
N-6-hydroxyl-2-purinyl)amide H
H
11,N (L)-2-(4-methoxypyridyl)-1H-benzi "
H OH
79 midazole-4-[N-(1-hydroxymethyl-2- 0*~ 93 p-nitrophenylhydroxyethyl)]amide OCH3 H, / " "

H
(L)-2-(4-methoxypyridyl)- I H-benzi "- / " H
80 midazole-4-[N-(l -hydroxymethyl-2- HO NH H 93 /
p-aminophenylhydroxyethyl)]amide OCH3 c 2-(4-methoxypyridyl)-IH-benzimida "- "
"
81 zole-4-[N-(l -m ethyl -2-p-chlorophen CH 94 ylhydroxyethyl)]amide OCH3 HO NH

" H
82 2-(4-methoxypyridyl)-I H-benzimida ~" 90 zole-4-(N-N '-piperidinyl)amide N- H
83 2-(4-methoxypyridyl)-1 H-benzimida /HN ~N
/ J\ 93 zole-4-(N-2-piperazinyl)amide OCH3 H

N N
84 2-(4-methoxypyridyl)-IH-benzimida / I \ )__H

zole-4-(N-2'-benzimidazolyl)amide OCH3 H

N H
85 2-(4-methoxypyridyl)-l H-benzimida 91 zole-4-(N-o-aminophenyl)amide CH3 NH, N- H
86 2-(4-methoxypyridyl)-1H-benzimida / JJ \ 91 tole-4-(N-5-benzim idazolonyl)amide / N~0 H
2-(4-methoxypyridyl)-1H-benzimida "
87 zole-4-(N-4'-carbonamido-5 '-imidaz HzN N 93 olyl)amide ocH3 "

H
N ry/ N
88 2-(4-methoxypyridyl)- I H-benzimida / 92 zole-4-(N-4' -pyrazolyl)amide N-89 2-(4-methoxypyridyl)-1 H-benzimida /N-N NH 93 tole-4-(N-(N'-piperazinyl))amide \-j OCH3 N- N\
90 2-(4-methoxypyridyl)- I H-benzimida I 94 zole-4-(N-2-pyrazinyl)amide N N/

2-(4-methoxypyridyl)-1H-benzimida 91 N I( \

zole-4-(N-2-pyrimidinyl)amide -\ry"N

N \
92 2-(4-methoxypyridyl)-I H-benzimida 92 tole-4-(N-2-pyridyl)amide N /

N
cH
93 2-(4-methoxypyridyl)-IH-benzimidaz 93 ole-4-(N-4-methyl-5-thiazolyl)amide \ N~

2-(4-methoxypyridyl)-I H-benzimida "?~H
94 zole-4-(N-2,4-dihydroxyl-5-pyrimidi 94 N
nyl)amide OCH3 OCHE
2-(4-methoxypyridyl)- I H-benzimida "- N
95 zole-4-(N-4,6-dimethoxy-2-pyrimidi / 90 nyl)amide OCH3 \\"
OCHE
ci 2-(4-methoxypyridyl)-1 H-benzimida "- N
96 zole-4-(N-4-chloro-6-amino-2-pyrim / N- / 94 idinyl)amide oCH3 "

2-(4-methoxypyridyl)- I H-benzimida "-97 zole-4-(N-4,6-dichloro-5-pyrimidiny N 92 I)amide OCH3 "

N- H
98 2-(4-methoxypyridyl)-1H-benzimida aF

zole-4-(N-o-fluorophenyl)amide OCH3 2-(4-methoxypyridyl)-I H-benzimida 99 zole-4-(N-2-hydroxyl-4-pyrimidinyl 94 )amide OCH3 õO" N

iH
100 2-(4-methoxypyridyl)-l H-benzimida 93 tole-4-(N-6-purinyl)amide N- N

OH
N-101 2-(4-methoxypyridyl)-1H-benzimidaz / 90 ole-4-(N-6-hydroxyl-2-purinyl)amide /
-H N H

H
CIN
(L)-2-(6-methoxypyridyl)-1 H-benzi I " OH
102 midazole-4-[N-(1-hydroxymethyl-2- / 91 HO I" H
p-nitrophenylhydroxyethyl)]amide I OCH3 t4 N H
(L)-2-(6-methoxypyridyl)- I H-benzi H OH
103 midazole-4-[N-(1-hydroxymethyl-2- 93 p-aminophenylhydroxyethyl)]amide HO NH H

CI I H
2-(6-methoxypyridyl)-1 H-benzimida H
104 zole-4-[N-(1-methyl-2-p-chlorophen CH3 93 ylhydroxyethyl)]amide OCH3 HO NH

H
N
~ \" 94 105 2-(6-methoxypyridyl)-I H-benzimida &-OCH3 zole-4-(N-N'-piperdinyl)amide HN N
106 2-(6-methoxypyridyl)-1 H-benzimida N 89 zole-4-(N-2-piperazinyl)amide N

107 2-(6-methoxypyridyl)-1H-benzimida N "-_ 93 zole-4-(N-2'-benzimidazolyl)amide N
H

H
108 2-(6-methoxypyridyl)-1H-benzimida a,,NH2 zole-4-(N-o-aminophenyl)amide H

109 2-(6-methoxypyridyl)-IH-benzimidaz &I- I \ N O 90 ole-4-(N-5-benzimidazolonyl)amide \ H / N~ OCH3 H
2-(6-methoxypyridyl)- I H-benzimida 110 zole-4-(N-4'-carbonamido-5'-imidaz H2N I 89 olyl)amide H

H
/N
2-(6-methoxypyridyl)-IH-benzimida \N N{
111 { ~ 93 zole-4-(N-4' -pyrazoly l)am ide / ocH, NH

112 2-(6-methoxypyridyl)-1H-benzimida N /H- ~NH 93 tole-4-(N-(N'-piperazinyl))amide { \-/ OCHs 113 2-(6-methoxypyridyl)-1H-benzimida &-O-H3 94 zole-4-(N-2-PYrazinY1) amide H

114 2-(6-methoxypyridyl)-1 H-benzimida {"~ \ 90 zole-4-(N-2-pyrimidinyl)amide { /N HN
OCHE

N \
115 2-(6-methoxypyridyl)-1 H-benzimida a-OCH, 93 zol e-4-(N-2-pyridyl)amide \H /

116 2-(6-methoxypyridyl)-I H-benzimidaz 92 ole-4-(N-4-methyl-5-thiazolyl)amide { N
ocH, S H

2-(6-methoxypyridyl)-1 H-benzimida"-117 zole-4-(N-2,4-dihydroxyl-5-pyrimidi HO \\ / 86 nyl)amide OcH, OH

OCH22-(6-methoxypyridyl)-1 H-benzimida N-118 zole-4-(N-4,6-dimethoxy-2-pyrimidi N-< 91 nyl)amide "
OCH3 C;õ, CI
2-(6-methoxypyridyl)-1 H-benzimida N
119 zole-4-(N-4-chloro-6-amino-2-pyrim N~ " N-\\ ~ 90 idinyl)amide "
OCF1, NHz CI
2-(6-methoxypyridyl)-I H-benzimida N-120 zole-4-(N-4,6-dichloro-5-pyrimidiny ~" N 92 I)amide I / OCHE \ /
2-(6-methoxypyridyl)-I H-benzimida H

zole-4-(N-o-fluorophenyl)amide / OCH3 aF

2-(6-methoxypyridyl)-I H-benzimida I"
122 zole-4-(N-2-hydroxyl-4-pyrimidiny) )amide OCH3 HO" N
NH
123 2-(6-methoxypyridyl)-I H-benzimida N 92 ~
zole-4-(N-6-purinyl)am ide I\\ I
/ OCH N H
OH
124 2-(6-methoxypyridyl)- I H-benzimidaz jZ, N 88 ole-4-(N-6-hydroxyl-2-purinyl)amide N J
OCHE H H

(L)-2-(4-dimethylaminopyridyl)-I H- O2N ,0* H
125 benzimidazole-4-[N-(1-hydroxymet H ~H H 93 hyl-2-p-nitrophenylhydroxyethyl)]a NCH' NH
mide HO / H
HJ

(L)-2-(4-dimethylaminopyridyl)- I H-" \ H
126 benzimidazole-4-[N-(1-hydroxymet "I I / H OH

hyl-2-p-am inophenylhydroxyethyl)] / i`"' NH
amide HO / H
CHI

Cl \ H
2-(4-dimethylaminopyridyl)-1 H-ben N I H
127 zimidazole-4-[N-(1-methyl-2-p-chlo /CHI / CH3 90 rophenylhydroxyethyl)]amide HO NH

H
128 2-(4-dimethylaminopyridyl)-1 H-benzi "I N N 94 midazole-4-(N-N'-piperidinyl)amide / NCH, CHI

HN H 92 "_( N 129 2-(4-dimethylaminopyridyl)- I H-benzi "I
midazole-4-(N-2-piperazinyl)amide N/CH3 H
H
CHI

2-(4-dimethylaminopyridyl)-1H-ben N \ H
130 zimidazole-4-(N-2'-benzimidazolyl) CHI ~ 94 amide H

~
131 2-(4-dimethylaminopyridyl)-1 H-benzi &N aNH2 midazole-4-(N-o-aminophenyl)amide /CH3 CHI

2-(4-dimethylaminopyridyl)-1 H-ben N
132 zimidazole-4-(N-5-benzimidazolony CH3 / >~ 93 I)amide H H
CHI

H
~N N
2-(4-dimethylaminopyridyl)-1H-ben N
133 zimidazole-4-(N-4'-carbonamido-5'- 86 CH' HpN
imidazolyl)amide i H

H
N N
134 2-(4-dimethylaminopyridyl)-1H-ben N

zimidazole-4-(N-4'-pyrazolyl)amide NCH3 CH NH
2-(4-dimethylaminopyridyl)-IH-ben 135 zimidazole-4-(N-(N'-piperazinyl)) CHI
{ /N- ~ \JNH 93 amide ~N
136 2-(4-dimethylaminopyridyl)-1 H-ben NI \ \ 11 /J 93 zimidazole-4-(N-2-pyrazinyl)amide INCH, H/ \Nj CHI

137 2-(4-dimethylaminopyridyl)-1H-benzi I 88 &N N
midazole-4-(N-2-pyrimidinyl)amide C"' NN/
I H
CHI

N N
138 2-(4-dimethylaminopyridyl)-1H-ben I I 89 N

zimidazole-4-(N-2-pyridyl)amide / N ~
H

N N ~H' 2-(4-dimethylaminopyridyl)- I H-ben 139 zimidazole-4-(N-4-methyl-5-thiazol ,CH3 87 yl)amide I s H

2-(4-dimethylaminopyridyl)-1H-ben HO....
140 zimidazole-4-(N-2,4-dihydroxyl-5-p 88 yrimidinyl)amide I OH

2-(4-dimethylaminopyridyl)-1H-ben N N_ 141 zimidazole-4-(N-4,6-dimethoxy-2-p / Nom`"' N-{~ 90 yrimidinyl)amide CI
2-(4-dimethylaminopyridyl)-1H-ben N 6 N-142 zimidazole-4-(N-4-chloro-6-amino-2 / N/CH, N\ 89 -pyrimidinyl)amide CI
2-(4-dimethylaminopyridyl)- I H-ben Na _ 143 zimidazole-4-(N-4,6-dichloro-5-pyri / CH3 \\N N 93 midinyl)amide H
144 2-(4-dimethylaminopyridyl)-1H-benzi NI N\ 93 midazole-4-(N-o-fluorophenyl)amide / ~+3 aF

2-(4-dimethylaminopyridyl)-1 H-ben i H
Na 45 zimidazole-4-(N-2-hydroxyl-4-pyri / 'C~ N, 88 midinyl)amide /JI\
H3 HO"

IH
146 2-(4-dimethylaminopyridyl)-1 H-ben LN/CH3 zimidazole-4-(N-6-purinyl)amide I \N N

OH
2-(4-dimethylaminopyridyl)-1 H-ben 147 zimidazole-4-(N-6-hydroxyl-2-purin NI / ,,, 93 yl)amide -N N N

(L)-2-(2,3,4-trimethoxyphenyl)- I H- I \ H OH
148 benzimidazole-4-[N-(1-hydroxymet OCH3 / H 92 hyl-2-p-nitrophenylhydroxyethyl)] HO %" H
amide (L)-2-(2,3,4-trimethoxyphenyl)-IH- Ow 149 benzimidazole-4-[N-(I-hydroxymet ocx3 I /
hyl-2-p-aminophenylhydroxyethyl)]
amide HO % H H

2-(2,3,4-trimethoxyphenyl)-1H-benz H
150 imidazole-4-[N-(1-methyl-2-p-chlor 0CH3 / CH3 91 ophenylhydroxyethyl)]amide HO NH

H
151 2-(2,3,4-trimethoxyphenyl)-1 H-benzi OCH3 N\N 93 midazole-4-(N-N'-piperidinyl)amide OCH3 OCH3 HN N "() 152 2-(2,3,4-trimethoxyphenyl)-I H-benz 3 92 imidazole-4-(N-2-piperazinyl)amide N
H

2-(2,3,4-trimethoxyphenyl)- I H -benz :87 \ 153 imidazole-4-(N-2'-benzimidazolyl) 0CH3 I 93 amide N
H

154 2-(2,3,4-trimethoxyphenyl)-IH-benzi - N\ ocii3 90 midazole-4-(N-o-aminophenyl)amide aINK, 2-(2,3,4-trimethoxyphenyl)-1 H-benz N
155 imidazole-4-(N-5-benzimidazolonyl) 0th3 >== 92 H
amide \H/~"

H
OC}j3 OCH3 N N
2-(2,3,4-trimethoxyphenyl)-I H-benz 1-1 I \\
156 imidazole-4-(N-4'-carbonamido-5'-i OCH, HZN N 87 midazolyl)amide 157 2-(2,3,4-trimethoxyphenyl)-1H-benz 93 j0CH 3 imidazole-4-(N-4'-pyrazolyl)amide NH

2-(2,3,4-trimethoxyphenyl)-1H-benz 158 imidazole-4-(N-(N'-piperazinyl)) _ OCH N-NNH 94 amide OCH3 OC1i3 N
159 2-(2,3,4-trimethoxyphenyl)-1 H-benz OCH3 90 imidazole-4-(N-2-pyrazinyl)amide N
H
OCH3 0~3 160 2-(2,3,4-trimethoxyphenyl)-1H-benz - NI \ 94 0Cf~3 imidazole-4-(N-2-pyrimidinyl)amide N N/
H
OCH3 0C"3 2-(2,3,4-trimethoxyphenyl)- I H-benz -imidazole-4-(N-2-pyridyl)amide \ / H

2-(2,3,4-trimethoxyphenyl)- I H-benz 162 imidazole-4-(N-4-methyl-5-thiazolyl )amide S H

p`
2-(2,3,4-trimethoxyphenyl)- I H-benz 163 imidazole-4-(N-2,4-dihydroxyl-5-py 94 rimidinyl)amide OH

2-(2,3,4-trimethoxyphenyl)- I H-benz N-164 imidazole-4-(N-4,6-dimethoxy-2-py \ / 3 N-C\ 93 rimidinyl)amide "

2-(2,3,4-trimethoxyphenyl)-1 H-benz N
165 imidazole-4-(N-4-chloro-6-amino-2- \ / 0CH3 N\ 90 pyrimidinyl)amide "
NHT

2-(2,3,4-trimethoxyphenyl)-IH-benz _ N-166 imidazole-4-(N-4,6-dichloro-5-pyri \ / 0013 N11-1 91 midinyl)amide N
CI

167 2-(2,3,4-trimethoxyphenyl)-1H-benzi \-/ 0.113 I \ "\ 93 midazole-4-(N-o-fluorophenyl)amide _ IH
2-(2,3,4-trimethoxyphenyl)- I H-benz 168 imidazole-4-(N-2-hydroxyl-4-pyrimi OCH3 N, 89 dinyl)amide Ho~N
OCH3 ~CH3 NH
169 2-(2,3,4-trimethoxyphenyl)-I H-benz - , N ocH3 88 imidazole-4-(N-6-purinyl)amide \N N
H
~CH3 OCH3 OH
2-(2,3,4-trimethoxyphenyl)- I H-benz 170 imidazole-4-(N-6-hydroxyl-2-puriny OtH3 "/ 89 I)amide N H

(L)-2-(3-hydroxyl-4-methoxyphenyl OH H
H OH
171 )-1 H-benzimidazole-4-[N-(I -hydrox - 3 87 ymethyl-2-p-nitrophenylhydroxyeth \ /
HO %H H
yl)]amide (L)-2-(3-hydroxyl-4-methoxyphenyl OH H2N \ H
172 )-1H-benzimidazole-4-[N-(I-hydrox - I / H OH H 90 \ / CH3 ymethyl-2-p-aminophenylhydroxyet NH
hyl)]amide HO / H

OH H
2-(3-hydroxyl-4-methoxyphenyl)- I 173 H-benzimidazole-4-[N-(1-methyl-2-o0 3 H CH 90 p-chlorophenylhydroxyethyl)]amide HO NH
2-(3-hydroxyl-4-methoxyphenyl)-I OH NON
174 H-benzimidazole-4-(N-N'-piperidin 0 13 91 yl)amide 2-(3-hydroxyl-4-methoxyphenyl)- I OH /HN N
175 H-benzimidazole-4-(N-2-piperazinyl \ / OCH3 93 )amide N
H
_OH O
2-(3-hydroxyl-4-methoxyphenyl)- I
176 H-benzimidazole-4-(N-2'-benzimida \ / OCH3 93 zolyl)amide H

OH H
2-(3-hydroxyl-4-methoxyphenyl)-I N
177 H-benzimidazole-4-(N-o-aminophen _ 03 I \ \ 94 yl)amide NHz OH H
2-(3-hydroxyl-4-methoxyphenyl)- I N
178 H-benzimidazole-4-(N-5-benzimida _ 3 >~0 90 zolonyl)amide H H

H
2-(3-hydroxyl-4-methoxyphenyl)-1 OH / N
179 H-benzimidazole-4-(N-4'-carbonami octb HzN 86 do-5'-imidazolyl)amide H
H

N
OH
2-(3-hydroxyl-4-methoxyphenyl)- I
180 H-benzimidazole-4-(N-4'-pyrazolyl) 0CH3 92 amide NH
2-(3-hydroxyl-4-methoxyphenyl)-I OH _ 181 H-benzimidazole-4-(N-(N'-piperazi3 N-N NH 91 nyl))amide 2-(3-hydroxyl-4-methoxyphenyl)- I _OH N\
182 H-benzimidazole-4-(N-2-pyrazinyl) 3 I / 91 amide N N
H

2-(3-hydroxyl-4-methoxyphenyl)- I OH N
183 H-benzimidazole-4-(N-2-pyrimidiny _ otH3 93 I )amide "1 N
H
2-(3-hydroxyl-4-methoxyphenyl)- I OH
184 H-benzimidazole-4-(N-2-pyridyl) _ 3 92 amide H

2-(3-hydroxyl-4-methoxyphenyl)- I OH
185 H-benzimidazole-4-(N-4-methyl-5-t _ 0CH3 93 hiazolyl)amide s H

OH N
2-(3-hydroxyl-4-methoxyphenyl)- I
_ N~ p ~H3 HO -<\ 89 186 H-benzimidazole-4-(N-2,4-dihydrox <~
yl-5-pyrimidinyl)amide N Off 2-(3-hydroxyl-4-methoxyphenyl)-1 N-187 H-benzimidazole-4-(N-4,6-dimethox _ OCH3 N\ / 92 y-2-pyrimidinyl)amide N

OH cl 2-(3-hydroxyl-4-methoxyphenyl)- I N-188 H-benzimidazole-4-(N-4-chloro-6-a 0 3 92 mino-2-pyrimidinyl)amide N
NHZ
OH C' 2-(3-hydroxyl-4-methoxyphenyl)-I N_ 189 H-benzimidazole-4-(N-4,6-dichloro- _ OCH3 "N 93 5-pyrimidinyl)amide N

OH H
2-(3-hydroxyl-4-methoxyphenyl)-1 _ "
190 H-benzimidazole-4-(N-o-fluorophen3 94 yl)amide aF
2-(3-hydroxyl-4-methoxyphenyl)- I OH ~H
_ 191 H-benzimidazole-4-(N-2-hydroxyl-4 O3 N 90 -pyrimidinyl)amide HO -'N
2-(3-hydroxyl-4-methoxyphenyl)-I OH I-..
_ 192 H-benzimidazole-4-(N-6-purinyl) OCH3 N N 94 amide l IJ
\\N N
H
OH OH
2-(3-hydroxyl-4-methoxyphenyl)-I
193 H-benzimidazole-4-(N-6-hydroxyl-2 O13 N IN 89 -purinyl)amide -N~ I N~
H H
OZN
(L)-2-(2-pyridyl)-1H-benzimidazole H off 194 -4-[N-(1-hydroxymethyl-2-p-nitroph H 94 enylhydroxyethyl)]amide Ho %" H

HqN
(L)-2-(2-pyridyl)-1 H-benzimidazole N__ H off 195 -4-[N-(1-hydroxymethyl-2-p-aminop / 90 henylhydroxyethyl)]amide Ho %" H

ci H
2-(2-pyridyl)- I H-benzimidazole-4-[ N I H
196 N-(1-methyl-2-p-chlorophenylhydro CH3 93 xyethyl)]amide HO NH

D
2-(2-pyridyl)- I H-benzimidazole-4-( N- /N -N

N-N'-piperidinyl)amide /

H
198 2-(2-pyridyl)-IH-benzimidazole-4-( 91 0"-/ HN N
N-2-piperazinyl)amide H
199 2-(2-pyridyl)-1H-benzimidazole-4-( N- 93 N-2'-benzimidazolyl)amide N
H

2-(2-pyridyl)-1 H-benzimidazole-4-( N N

N-o-aminophenyl)amide NHz 201 2-(2-pyridyl)-1 H-benzimidazole-4-( I o 88 N-5-benzimidazolonyl)amide N
H H
H
2-(2-pyridyl)-1H-benzimidazole-4-( N N
202 N-4'-carbonamido-5'-imidazolyl) HZN N 86 amide "

,a 203 2-(2-pyridyl)-1H-benzimidazole-4-( N NI / 87 N-4'-pyrazolyl)amide NH H

204 2-(2-pyridyl)-1H-benzimidazole-4-( N N-N NH 92 N-(N'-piperazinyl))amide 0\/ 205 2-(2-pyridyl)-IH-benzimidazole-4-( N
N-2-pyrazinyl)amide N N
H

206 2-(2-pyridyl)-1 H-benzimidazole-4-( N- \

N-2-pyrimidinyl)amide N N N
H

- N \
207 2-(2-pyridyl)- I H-benzimidazole-4-( N 93 N-2-pyridyl)amide / \N
H

208 2-(2-pyridyl)-I H-benzimidazole-4-( N N 93 N-4-methyl-5-thiazolyl)amide S H

2-(2-pyridyl)-1H-benzimidazole-4-( OX,- HO H
209 N-2,4-dihydroxyl-5-pyrimidinyl) 88 amide off 2-(2-pyridyl)-1 H-benzimidazole-4-( N N-210 N-4,6-dimethoxy-2-pyrimidinyl) N-<\ 90 amide CI
2-(2-pyridyl)-1 H-benzimidazole-4-( N N-211 N-4-chloro-6-amino-2-pyrimidinyl) N\ / 93 amide "

CI

212 2-(2-pyridyl)-1H-benzimidazole-4-( N

\
N-4,6-dichloro-5-pyrimidinyl)amide N
CI

213 2-(2-pyridyl)-1H-benzimidazole-4-( N\ 91 N-o-fluorophenyl)amide O\,-_ INH
214 2-(2-pyridyl)- I H-benzimidazole-4-( N

N-2-hydroxyl-4-pyrimidinyl)amide HO" N
IH
215 2-(2-pyridyl)-I H-benzimidazole-4-( N
N-6-puridyl)amide N N 93 N N
H

OH
216 2-(2-pyridyl)-1H-benzimidazole-4-( N_ Ni NI 88 N-6-hydroxyl-2-purinyl)amide -N N N
H

dtN H
(L)-2-(3-pyridyl)-IH-benzimidazole "~ H OH
217 -4-[N-(1-hydroxymethyl-2-p-nitroph H 93 enylhydroxyethyl)]amide HO NH
H
"~N H
(L)-2-(3-pyridyl)-IH-benzimidazole H off 218 -4-[N-(I-hydroxymethyl-2-p-aminop 94 henylhydroxyethyl)]amide HO NH H

H
N\ HN N
219 2-(3-pyridyl)- I H-benzimidazole-4-( ) 92 N-2-piperazinyl)amide H
H
N\
220 2-(3-pyridyl)-IH-benzimidazole-4-( II 92 N-2-pyrimidinyl)amide N Ni L)-2- 4- rid l)- I H-benzimidazole "
( ( pY Y )- " H off 221 -4-[N-(I -hydroxymethyl-2-p-nitroph / " 93 enylhydroxyethyl)]amide Ho %" H

HzN
L 2 4- rid 1 1 H-benzimidazole "
( )' '( pY Y )' N H off 222 -4-[N-(I -hydroxymethyl-2-p-aminop 94 henylhydroxyethyl)]amide HO %" H

H
\ HN N "",( 223 2-(4-pyridyl)-1 H-benzimidazole-4-( 90 N-2-piperazinyl)amide H
H

224 2-(4-pyridyl)- I H-benzimidazole-4-( " \ it 94 N-2-pyrimidinyl)amide N ry (L)-2-(3-pyridazinyl)-1H-benzimida Nj I \
H OH
225 zole-4-[N-(I -hydroxymethyl-2-p-nit / 92 rophenyihydroxyethyl)]amide HO H

(L)-2-(3-pyridazinyl)-I H-benzimida~ H off 226 zole-4-[N-(1-hydroxymethyl -2-p-am 91 inophenylhydroxyethyl)]amide HO %" H

H
2-(3-pyridazinyl)-1H-benzimidazole N~ I H
227 -4-[N-(1-methyl-2-p-chlorophenylhy CHI 94 droxyethyl)]amide HO NH

N "
2-(3-pyridazinyl)- I H-benzimidazole N' I N\No -4-(N-N'-piperdinyl)amide HN N
229 2-(3-pyridazinyl)-1H-benzimidazole N 90 -4-(N-2-piperazinyl)amide I N

N
230 2-(3-pyridazinyl)-IH-benzimidazole N I ~N--_ 91 -4-(N-2'-benzimidazolyl)amide H
H
2-(3-pyridazinyl)-1H-benzimidazole N%N N

-4-(N-o-am inophenyl)amide N
232 2-(3-pyridazinyl)-1 H-benzimidazole N' I \

-4-(N-5-benzimidazolonyl)amide H

H
2-(3-pyridazinyl)- I H-benzimidazole N , \
233 -4-(N-4'-carbonamido-5'-imidazolyl H , I > 86 N
)amide H

NCH
234 2-(3-pyridazinyl)- I H-benzimidazole N' I / 89 -4-(N-4'-pyrazolyl)amide NH

2-(3-pyridazinyl)- I H-benzimidazole N-r; NH 87 -4-(N-(N'-piperazinyl))amide ~

N
N' 2-(3-pyridazinyl)- I H-benzimidazole 236 ~ ~ 92 -4-(N-2-pyrazinyl)amide N N' H

237 2-(3-pyridazinyl)-I H-benzimidazole Nom' I \ 90 -4-(N-2-pyrimidinyl)amide /
H N
N
2-(3-pyridazinyl)-1H-benzimidazole N' -4-(N-2-pyridyl)amide N 91 I \N
H

239 2-(3-pyridazinyl)-1H-benzimidazole N' J \ 93 -4-(N-4-methyl-5-thiazolyl)amide S H H

2-(3-pyridazinyl)-1 H-benzimidazole Ho N N
240 -4-(N-2,4-dihydroxyl-5-pyrimidinyl) ~ 89 N
amide \ OH
2-(3-pyridazinyl)-1H-benzimidazole N% N- OCM, 241 -4-(N-4,6-dimethoxy-2-pyrimidinyl) 94 amide a 2-(3-pyridazinyl)-i H-benzimidazole N
242 -4-(N-4-chloro-6-amino-2-pyrimidin N- z 90 yl)amide ~~N
NHz CI
2-(3-pyridazinyl)-1H-benzimidazole N~ N_ 243 -4-(N-4,6-dichloro-5-pyrimidinyl) N 93 amide \
CI

H
244 2-(3-pyridazinyl)-l H-benzimidazole N' 92 -4-(N-o-fluorophenyl)amide III111III: 2-(3-pyridazinyl)-IH-benzimidazole IH

245 -4-(N-2-hydroxyl-4-pyrimidinyl) N, 88 amide HON

H
246 2-(3-pyridazinyl)-1 H-benzimidazole N' 91 -4-(N-6-purinyl)amide N

OH
N
247 2-(3-pyridazinyl)-1H-benzimidazole N' I N " 87 -4-(N-6-hydroxyl-2-purinyl)amide J
" "
H H
H H off (L)-2-(4-pyridazinyl)-1 H-benzimida " 02N
248 zole-4-[N-(1-hydroxymethyl-2-p-nit " 92 rophenylhydroxyethyl)]amide Ho %" H

(L)-2-(4-pyridazinyl)- I H-benzimida "~N I H off 249 zole-4-[N-(1-hydroxymethyl-2-p-am 90 inophenylhydroxyethyl)]amide HO " H

HN H
250 2-(4-pyridazinyl)-1 H-benzimidazole 94 -4-(N-2-piperazinyl)amide H

251 2-(4-pyridazinyl)-1 H-benzimidazole N \ 92 N
-4-(N-2-pyrimidinyl)amide N N/
H

(L)-2-(2-pyrazinyl)- I H-benzimidazo "\ I H OH
252 le-4-[N-(1-hydroxymethyl-2-p-nitro H 92 phenylhydroxyethyl)]amide N HO NH H

H2N \ H
(L)-2-(2-pyrazinyl)- I H-benzimidazo I H OH
253 le-4-[N-(1-hydroxymethyl-2-p-amin I / H 89 ophenylhydroxyethyl)]amide N~ HO %" H

C` H
2-(2-pyrazinyl)-1H-benzimidazole-4 H
254 -[N-(1-methyl-2-p-chlorophenylhydr )_~ NHCH3 94 oxyethyl)]amide N HO /

H
2-(2-pyrazinyl)- I H-benzimidazole-4 NN

-(N-N'-piperidinyl)amide HN H
,,_() 94 256 2-(2-pyrazinyl)-1H-benzimidazole-4 /
-(N-2-piperazinyl)amide N
H
NN
257 2-(2-pyrazinyl)-1H-benzimidazole-4 92 (N-2'-benzimidazolyl)amide H
O~N

H
N258 2-(2-pyrazinyl)-1H-benzimidazole-4 90 all,NH2 -(N-o-aminophenyl)amide 259 2-(2-pyrazinyl)-IH-benzimidazole-4 I \ N

~ 94 -(N-5-benzimidazolonyl)amide / N
H H

H
N
2-(2-pyrazinyl)-IH-benzimidazole-4 260 -(N-4'-carbonamido-5'-imidazolyl) H2 N 87 amide N/ H

H
Nq 261 2-(2-pyrazinyl)-I H-benzimidazole-4 ( / 90 -(N-4'-pyrazolyl)amide N NHN

2-(2-pyrazinyl)-1H-benzimidazole-4 N\ / NH 91 262 \--/ -(N-(N'-piperazinyl))amide NN_N
N

2-(2-pyrazinyl)- I H-benzimidazole-4 N\ N\

-(N-2-pyrazinyl)amide N

264 2-(2-pyrazinyl)- I H-benzimidazole-4 N\ NI \ 93 -(N-2-pyrimidinyl)amide N H

265 2-(2-pyrazinyl)- I H-benzimidazole-4 I 88 -(N-2-pyridyl)amide H

" CH3 266 2-(2-pyrazinyl)- I H-benzimidazole-4 II N 89 -(N-4-methyl-5-thiazolyl)amide ! / \
N S H

2-(2-pyrazinyl)- I H-benzimidazole-4 "--267 -(N-2,4-dihydroxyl-5-pyrimidinyl)a I HO \\ 87 N
mide N OH

OCHE
2-(2-pyrazinyl)- I H-benzimidazole-4 N-268 -(N-4,6-dimethoxy-2-pyrimidinyl)a 92 mide N

G
2-(2-pyrazinyl)-]H-benzimidazole-4 269 -(N-4-chloro-6-amino-2-pyrimidinyl 90 )amide N

CI
2-(2-pyrazinyl)-I H-benzimidazole-4N_ 270 -(N-4,6-dichloro-5-pyrimidinyl)ami fN

de "
N

N
2-(2-pyrazinyl)-1 H-benzimidazole-4 -(N-o-fluorophenyl)amide N F
N INH
272 2-(2-pyrazinyl)-1 H-benzimidazole-4 89 -(N-2-hydroxyl-4-pyrimidinyl)amide N /JI\
HO"
2-(2-pyrazinyl)-1 H-benzimidazole-4 273 Ni ( I 94 -(N-6-purinyl)amide N ~N N) H
OH

2-(2-pyrazinyl)- I H-benzimidazole-4 N~ NI)u N
274 N 89 -(N-6-hydroxyl-2-purinyl)amide H N N

H
(L)-2-(2-piperazinyl)-1 H-benzimida H off 275 zole-4-[N-(1-hydroxymethyl-2-p-nit HN 93 rophenylhydroxyethyl)]amide NH H0 H

H
H
,0*
(L)-2-(2-piperazinyl)-1H-benzimida H OH
276 zole-4-[N-(I-hydroxymethyl-2-p-am HN NH 90 inophenylhydroxyethyl)]amide NH HO / H

q H H
2-(2-piperazinyl)-1 H-benzimidazole I /
277 -4-[N-(1-methyl -2-p-chlorophenylhy HN CHI 91 droxyethyl)]amide NH Ho NH

H
278 2-(2-piperazinyl)-1 H-benzimidazole HN N\N 91 -4-(N-N'-piperidinyl)amide NH

H
HN N
279 2-(2-piperazinyl)-IH-benzimidazole HN Y 93 -4-(N-2-piperazinyl)amide NH N
H
N
280 2-(2-piperazinyl)-IH-benzimidazole HN (:)~N
~N~ 92 -4-(N-2'-benzimidazolyl)amide NH H

H
281 2-(2-piperazinyl)-1H-benzimidazole HN 1) 93 -4-(N-o-aminophenyl)amide aNH2 NH H

282 2-(2-piperazinyl)-1H-benzimidazole HN 1) N 0 94 -4-(N-5-benzimidazolonyl)amide H
NH H

H
2-(2-piperazinyl)-1H-benzimidazole 283 -4-(N-4'-carbonamido-5'-imidazolyl HN HzN I 89 N
H
)amide NH

H
N
284 2-(2-piperazinyl)-1 H-benzimidazole HN 92 -4-(N-4'-pyrazolyl)amide NH NH
285 2-(2-piperazinyl)- I H-benzim idazole HN H- ~92 -4-(N-(N'-piperazinyl))amide \--/ NH

N
286 2-(2-piperazinyl)-1H-benzimidazole \ 92 -4-(N-2-pyrazinyl)amide H~
NH H N N

287 2-(2-piperazinyl)-1 H-benzimidazole N H 93 -4-(N-2-pyrimidinyl)amide [ H
NH

288 2-(2-piperazinyl)-1H-benzimidazole HN I 92 -4-(N-2-pyridyl)amide NH N j 2-(2-piperazinyl)-1 H-benzimidazole N
289 "" \ 91 -4-(N-4-methyl-5-thiazolyl)amide ~NH S H

2-(2-piperazinyl)-1 H-benzim idazole N H
290 -4-(N-2,4-dihydroxyl-5-pyrimidinyl) HN H \ 87 amide NH off 2-(2-piperazinyl)-l H-benzimidazole N-291 -4-(N-4,6-dimethoxy-2-pyrimidinyl) HIN N--C\ 90 amide NH N

cl 2-(2-piperazinyl)-1 H-benzimidazole N-292 -4-(N-4-chloro-6-amino-2-pyrimidin HN N-<\ 88 yl)amide NH "

CI
2-(2-piperazinyl)-1 H-benzimidazole N
293 -4-(N-4,6-dichloro-5-pyrimidinyl)a HN K / N 93 mide NH "
C I

H
2-(2-piperazinyl)-1 H-benzimidazole 294 HN aF
-4-(N-o-fluorophenyl)amide NH 2-(2-piperazinyl)-1 H-benzimidazole i"
295 -4-(N-2-hydroxyl-4-pyrimidinyl)ami HN 89 de NH
HO N
Iõ
296 2-(2-piperazinyl)-1 H-benzimidazole 90 -4-(N-6-purinyl)amide N I"l\~ I h ~N" N N~

OH

297 2-(2-piperazinyl)- I H-benzim idazole HN N N 87 -4-(N-6-hydroxyl-2-purinyl)amide Il\ / J
NH H " H

(L)-2-(N,N'-diethyl-2-piperazinyl)-1 H3C~N I H OH
298 H-benzimidazole-4-[N-(1-hydroxym H 90 ethyl-2-p-nitrophenylhydroxyethyl)] N HO %" H
amide HzN
(L)-2-(N,N'-diethyl-2-piperazinyl)-1 H3C N H O"

299 H-benzimidazole-4-[N-(1-hydroxym / H K
ethyl-2-p-am inophenylhydroxyethyl HO /" H
)]amide H
2-(N,N'-diethyl-2-piperazinyl)-1H-b H,C^N HN N
300 enzimidazole-4-(N-2-piperazinyl)am ~N 90 ide u H

2-(N,N'-diethyl-2-piperazinyl)- I H-b H3CN N
301 enzimidazole-4-(N-2-pyrimidinyl)a / I 91 mide "~ H N' H
302 (L)-2-(N-piperazinyl)-IH-benzimida "- H off H 92 zole-4-[N-(1-hydroxymethyl-2-p-nit NH NH
rophenylhydroxyethyl)]amide HO / H

HZN
H
303 (L)-2-(N-p -1H-benzimida N~ H off H 91 zole-4-[N-(1-hydroxymethyl-2-p-am NH NH
inophenylhydroxyethyl)]amide HO / H
2-(N-piperazinyl)-1H-benzimidazole \N c I \ H "
304 -4-[N-(1-methyl-2-p-chlorophenylhy 92 HO NH /
droxyethyl)]amide NH CH3 H
305 2-(N-piperazinyl)- I H-benzimidazole "" 93 -4-(N-N'-piperidinyl)amide NH

\ ^ /HN H
306 2-(N-piperazinyl)-1H-benzimidazole 91 -4-(N-2-piperazmyl)amide NH
H
H
N
307 2-(N-piperazinyl)- I H-benzimidazole 92 -4-(N-2'-benzimidazolyl)amide INH
(::~CN
H

H
308 2-(N-piperazinyl)-IH-benzimidazole 90 -4-(N-o-aminophenyl)amide NH
aNH2 " )::rN>~o 2-(N-piperazinyl)-1H-benzimidazole -4-(N-5-benzimidazolonyl)amide NH N H 91 /N
2-(N-piperazinyl)-1H-benzimidazole N N
I ) 90 310 -4-(N-4'-carbonamido-5'-imidazolyl HZN ry NH
)amide H
NI N
311 2-(N-piperazinyl)-1H-benzimidazole / 93 4-(N-4'-pyrazolyl)amide N H
NH

312 2-(N-piperazinyl)-IH-benzimidazole /H_N; NH 91 -4-(N-(N'-piperazinyl))amide fNH

^\II N
313 2-(N-piperazinyl)-1H-benzimidazole 92 N I I \
-4-(N-2-pyrazinyl)amide NH /
N N
H

N
314 2-(N-piperazinyl)-1H-benzimidazole 93 N Ni N/
-4-(N-2-pyrimidinyl)amide NH
H

315 2-(N-piperazinyl)- I H-benzimidazole " NI \ 94 -4-(N-2-pyridyl)amide H
N
H

316 2-(N-piperazinyl)-1H-benzimidazole N 94 -4-(N-4-methyl-5-thiazolyl)amide NH
v S H

2-(N-piperazinyl)-IH-benzimidazole N XN~ H
317 -4-(N-2,4-dihydroxyl-5-pyrimidinyl) 88 amide NH N
OH

2-(N-piperazinyl)-1H-benzimidazole N N_ 318 -4-(N-4,6-dimethoxy-2-pyrimidinyl) N-~N / 90 NH \\
amide CI
2-(N-piperazinyl)-IH-benzimidazole N N
319 -4-(N-4-chloro-6-amino-2-pyrimidin N-{\ 91 NH
yl)amide CI
2-(N-piperazinyl)-IH-benzimidazole N
320 -4-(N-4,6-dichloro-5-pyrimidinyl)a I N 93 mide vNH

H
321 2-(N-piperazinyl)-1H-benzimidazole "~ N

-4-(N-o-fluorophenyl)amide NH 2-(N-piperazinyl)-IH-benzimidazole N i"

322 -4-(N-2-hydroxyl-4-pyrimidinyl)ami , 88 de NH N
HO
\ IH
2-(N-piperazinyl)-IH-benzimidazole N 89 N -4-(N-6-purinyl)amide NH

\N N
H
OH
324 2-(N-piperazinyl)-IH-benzimidazole "" N N 87 -4-(N-6-hydroxyl-2-purinyl)amide INH
H \" H

(L)-2-(N-ethyl-N'-piperazinyl)-I H-b N H OH
325 enzimidazole-4-[N-(1-hydroxymeth 92 yl-2-p-n itrophenylhydroxyethyl)]am NcH3 HO NFi H
ide /

(L)-2-(N-ethyl-N'-piperazinyl)-IH-b NN,' I ::~ H OH
326 enzimidazole-4-[N-(I-hydroxymeth H 93 ~NCH3 NH H
yl-2-p-aminophenylhydroxyethyl)]a Fio mide H
/HN N
327 2-(N-ethyl-N'-piperazinyl)-1H-benzi N \N) 92 midazole-4-(N-2-piperazinyl)amide NCH3 H
N NI
328 2-(N-ethyl-N'-piperazinyl)-1H-benzi 93 midazole-4-(N-2-pyrimidinyl)amide NcH, NN~
H

H
L 2-2- rrol 1 1H-benzimidazol " H off 329 (}- ( pY Y )- " 92 e-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide H~ / H H

330 (L)-2-(2-pyrrolyl)- I H-benzimidazol " H OH H 91 e-4-[N-(1-hydroxymethyl-2-p-amino NH H
phenylhydroxyethyl)]amide H
c ()) H
2-(2-pyrrolyl)-1H-benzimidazole-4-[ N
H
331 N-(I -methyl-2-p-chlorophenylhydro CH3 xyethyl)]amide Ho NH 92 2-(2-pyrrolyl)-1H-benzimidazole-4-( " N"' N

N-N'-piperidinyl)amide H
H HN N
333 2-(2-pyrrolyl)-1 H-benzimidazole-4-( __ ~ 90 N-2-piperazinyl)amide N
H
H N H
334 2-(2-pyrrolyl)-1H-benzimidazole-4-( " \93 N-2'-benzimidazolyl)amide D/ c N

H
N\
H 335 2-(2-pyrrolyl)-1H-benzimidazole-4-( N 90 N-o-aminophenyl)amide NHZ

H
a)= H
336 2-(2-pyrrolyl)-1H-benzimidazole-4-( "

N-5-benzimidazolonyl)amide H H

H
2-(2-pyrrolyl)-I H-benzimidazole-4-( H
337 N-4'-carbonamido-5'-imidazolyl)am H2N > 85 \ / N
ide H
N---N
H
338 2-(2-pyrrolyl)-1 H-benzimidazole-4-( " 90 N-4'-pyrazolyl)amide NH
H
2-(2-pyrrolyl)-1H-benzimidazole-4-( " N-N NH 92 N (N' piperazinyl))amide N
____e H I
340 2-(2-pyrrolyl)-IH-benzimidazole-4-( 95 N-2-pyrazinyl)amide N N
H
H N \
341 2-(2-pyrrolyl)-I H-benzimidazole-4-( 94 N-2-pyrimidinyl)amide N
I N/
H
H N \
342 2-(2-pyrrolyl)-IH-benzimidazole-4-( 94 N-2-pyridyl)amide N
H

H
343 2-(2-pyrrolyl)-1H-benzimidazole-4-( " 95 N-4-methyl-5-thiazolyl)amide < N~
S H

2-(2-pyrrolyl)- I H-benzimidazole-4-( NZH
HO N` 87 344 N-2,4-dihydroxyl-5-pyrimidinyl)ami p \
de 2-(2-pyrrolyl)- I H-benzimidazole-4-( H N-345 N-4,6-dimethoxy-2-pyrimidinyl)ami N- N 94 de OCHj CI
2-(2-pyrrolyl)-1 H-benzimidazole-4-( H N-346 N-4-chloro-6-amino-2-pyrimidinyl)a N 91 \\N /
mide CI

H N-347 2-(2-pyrrolyl)-1H-benzimidazole-4-( " 93 N-4,6-dichloro-5-pyrimidinyl)amide N~
H 2-(2-pyrrolyl)- I H-benzimidazole-4-( " aF

\'/
N-o-fluorophenyl)amide H IH
349 2-(2-pyrrolyl)-1H-benzimidazole-4-( 86 N-2-hydroxyl-4-pyrimidinyl)amide HO)N
H
350 2-(2-pyrrolyl)-1H-benzimidazole-4-( N 92 N N
N-6-purinyl)amide N~
H
OH
H
351 2-(2-pyrrolyl)- I H-benzimidazole-4-( "_~ N N~ N 87 N-6-hydroxyl-2-purinyl)amide / Il H N H

(L)-2-(4-methyl-5 -am inoth iazolyl)- I N CH3 02N \ H
352 H-benzim idazole-4-[N -(I -hydroxym I / H off H 93 ethyl-2-p-nitrophenylhydroxyethyl)] S NH2 amide Ho H H
(L)-2-(4-methyl-5 -am inoth iazolyl)- I CH3 HzN
off H 91 353 H-benzimidazole-4-[N-(I-hydroxym I \ / H
ethyl-2-p-am inophenylhydroxyethyl aSNH2 NH
)]amide HO H

CH3 ci H
2-(4-methyl-5-aminothiazolyl)-1H-b N H
354 enzimidazole-4-[N-(1-methyl-2-p-ch lorophenylhydroxyethyl)]amide As~,NH2 Ho NH CH3 93 2-(4-methyl-5-aminothiazolyl)-IH-b N N"_ N
355 enzimidazole-4-(N-N'-piperidinyl)a AS~NH2 94 mide 2-(4-methyl-5-aminothiazolyl)-1H-b HN N
356 enzimidazole-4-(N-2-piperazinyl)am 90 ide S NHZ N
H

2-(4-methyl-5-aminothiazolyl)-1 H-b N N H
357 enzimidazole-4- N-2'-benzimidazol ( AS NHZ 94 N
yl)amide H

2-(4-methyl-5-aminothiazolyl)-IH-b aSNH2 N358 enzimidazole-4-(N-o-aminophenyl)a 93 mide NHS

2-(4-methyl-5-aminothiazolyl)-IH-b aSNH2 I \ N
o 94 359 enzimidazole-4-(N-5-benzimidazolo ~
de H H
nyl)ami N
2-(4-methyl-5-aminothiazolyl)-1 H-b N-360 enzimidazole-4-(N-4'-carbonamido- H1N I 90 5'-imidazolyl)amide s NHZ H

CH3 , H
2-(4-methyl-5-aminothiazolyl)-1H-b NI
361 enzimidazole-4-(N-4'-pyrazolyl)ami 94 de NH\

2-(4-methyl-5-aminothiazolyl)-1H-b N
362 enzimidazole-4-(N-(N'-piperazinyl)) AS~NH2 N-NNH 92 / ~l amide 2-(4-methyl-5-aminothiazolyl)- I H-b N-363 enzimidazole-4-(N-2-pyrazinyl)amid 94 e H

2-(4-methyl-5-am inoth i azolyl)- I H-b N N \
364 enzimidazole-4-(N-2-pyrimidinyl)a AS NH2 / 94 mide H N

N 365 2-(4-methyl-5-aminothiazolyl)-IH-b 93 enzimidazole-4-(N-2-pyridyl)amide NS NH2 N H

2-(4-methyl-5-aminothiazolyl)-1H-b N N CH3 366 enzimidazole-4-(N-4-methyl-5-thiaz As~,NH2 90 ol yl)amide s H

2-(4-methyl-5-aminothiazolyl)-IH-b N N~ 91 367 enzimidazole-4-(N-2,4-dihydroxyl-5 Ho S NH2 \ /
-pyrimidinyl)amide OH

2-(4-methyl-5-aminothiazolyl)-I H-b aS N-368 enzimidazole-4-(N-4,6-dimethoxy-2 NH2 N~ / 93 -pyrimidinyl)amide N

CH3 Cl 2-(4-methyl-5-am inothiazolyl)-1H-b ~SNH2 N369 enzimidazole-4-(N-4-chloro-6-amin N-- / 93 o-2-pyrimidinyl)amide N

CH3 Cl 2-(4-methyl-5-am inothiazolyl)-IH-b ~SNH2 N-370 enzimidazole-4-(N-4,6-dichloro-5-p ~N 88 yrimidinyl)amide N
ci 2-(4-methyl-5-aminothiazolyl)-1H-b N \ N
371 enzimidazole-4-(N-o-fluorophenyl)a AS NH2 I 89 mide F

2-(4-methyl-5-aminothiazolyl)- I H-b N
372 enzimidazole-4-(N-2-hydroxyl-4-pyr /\S NH2 N 87 imidinyl)amide N N"
2-(4-methyl-5-aminothiazolyl)-1 H-b 1~ 92 373 enzimidazole-4-(N-6-purinyl)amide AS NH2 "~ I /IJ"

N
H
CH3 off 2-(4-methyl-5-aminothiazolyl)-IH-b N-374 enzimidazole-4-(N-6-hydroxyl-2-pur A5~NH2 " I I 90 inyl)amide S )"~ J
H " H

H
(L)-2-(2-quinolinyl)-IH-benzimidaz ON
H OH
375 ole-4-[N-(1-hydroxymethyl-2-p-nitr i 91 ophenylhydroxyethyl)]amide "O H "

(L)-2-(2-quinolinyl)-1 H-benzimidaz N H H OH
376 ole-4-[N-(1-hydroxymethyl-2-p-ami I I / 93 nophenylhydroxyethyl)]amide HO "" H

c' 2-(2-quinolinyl)-IH-benzimidazole- N 377 4-[N-(I-methyl-2-p-chlorophenylhy ())H

droxyethyl)]amide HO NH

H
378 2-(2-quinolinyl)-1H-benzimidazole- 94 4-(N-N'-piperidinyl)amide HN N
379 2-(2-quinolinyl)-IH-benzimidazole- N 90 4-(N-2-piperazinyl)amide N
H

2-(2-quinolinyl)-I H-benzimidazole- N~ ' I \ "~

4-(N-2'-benzimidazolyl)amide / N
H

H
2-(2-quinolinyl)-1H-benzimidazole- 381 92 4-(N-o-aminophenyl)amide aNH2 N
382 2-(2-quinolinyl)-IH-benzimidazole->==o 91 4-(N-5-benzimidazolonyl)amide / H
H

H
2-(2-quinolinyl)-I H-benzimidazole- N\ \ /N N
383 4-(N-4'-carbonamido-5'-imidazolyl) HzN N 91 amide H
O

H
N N
384 2-(2-quinolinyl)-IH-benzimidazole- N\

4-(N-4'-pyrazolyl)amide NH
H
2-(2-quinolinyl)-l H-benzimidazole- N~ H -N ~ NH 92 4-(N-(N'-piperazinyl))amide N\ \
386 2-(2-quinolinyl)-]H-benzimidazole- 93 4-(N-2-pyrazinyl)amide N N
H
N\ \
387 2-(2-quinolinyl)-IH-benzimidazole- N I 94 4-(N-2-pyrimidinyl)amide NN/
H

388 2-(2-quinolinyl)-IH-benzimidazole- NI 92 4-(N-2-pyridyl)amide H

-(2-quinolinyl)-IH-ben zimidazole-4-(N-4-methyl-5-thiazolyl)amide S H
N
2-(2-quinolinyl)-1 H-benzimidazole- "
" N\
HO 87 -<\ 390 4-(N-2,4-dihydroxyl-5-pyrimidinyl) N
amide OH

2-(2-quinolinyl)-IH-benzimidazole- N "
H
391 4-(N-4,6-dimethoxy-2-pyrimidinyl)a N 94 mide \

CI
2-(2-quinolinyl)-1H-benzimidazole- N N-392 4-(N-4-chloro-6-amino-2-pyrimidin N__\ / 93 yl)amide "

CI
2-(2-quinolinyl)- 1 H-benzimidazole- N N_ 393 4-(N-4,6-dichloro-5-pyrimidinyl)am <\N / N 93 ide cI
394 2-(2-quinolinyl)-IH-benzimidazole- N N\ 93 4-(N-o-fluorophenyl)amide F

2-(2-quinolinyl)-IH-benzimidazole- N I"
395 4-(N-2-hydroxyl-4-pyrimidinyl)ami N 88 de HO N
H
396 2-(2-quinolinyl)-1H-benzimidazole- 90 4-(N-6-purinyl)amide "

~N N
H
OH

397 2-(2-quinolinyl)-IH-benzimidazole- N/ N 85 N
4-(N-6-hydroxyl-2-purinyl)amide /

H/\\" H

H
(L)-2-(3-quinolinyl)-1H-benzimidaz N\ ( H OH
398 ole-4-[N-(1-hydroxymethyl-2-p-nitr 93 ophenylhydroxyethyl)Jamide HO H

H
(L)-2-(3-quinolinyl)-1 H-benzimidaz N\ H OH
399 ole-4-[N-(I -hydroxymethyl-2-p-ami H 91 nophenylhydroxyethyl)]am ide / HO NH "

HN N
400 2-(3-quinolinyl)-1H-benzimidazole- N~ ) 93 4-(N-2-piperazinyl)amide N
H
N\ ~
401 2-(3-quinolinyl)-IH-benzimidazole- 93 4-(N-2-pyrimidinyl)amide N'ON
H
ON
(L)-2-(2-piperidinyl)- I H-benzimidaz 0*~
H
H OH
402 ole-4-[N-(1-hydroxymethyl-2-p-nitr 91 ophenylhydroxyethyl)]amide HO /" H

FiZN
(L)-2-(2-piperidinyl)-1 H-benzimidaz H "
N OH
403 ole-4-[N-(1-hydroxymethyl-2-p-ami 89 nophenylhydroxyethyl)jam ide HO NH H

CI J)* 2-(2-piperidinyl)-1H-benzimidazole- N H
404 4-[N-(1-methyl-2-p-chlorophenylhy CH3 91 droxyethyl)]amide HO NH

H
405 2-(2-piperidinyl)-1 H-benzimidazole- /N\N 92 4-(N-N'- piperidinyl)amide H HN N
406 2-(2-piperidinyl)-1 H-benzimidazole- 90 4-(N-2-piperazinyl)amide N
H

407 2-(2-piperidinyl)-1 H-benzimidazole- N \93 4-(N-2'-benzimidazolyl)amide N
H

H
N \
2-(2-piperidinyl)-IH-benzimidazole- 408 93 4-(N-o-aminophenyl)amide H
H al~NH2 H N
409 2-(2-piperidinyl)-1H-benzimidazole- I 0 93 4-(N-5-benzimidazolonyl)amide /
N H
H

H
2-(2-piperidinyl)-1 H-benzimidazole- H - "
-11 410 4-(N-4'-carbonamido-5'-imidazolyl) I

amide H

H
N
N
4l 1 2-(2-piperidinyl)-I H-benzimidazole- 89 4-(N-4'-pyrazolyl)amide NH

412 2-(2-piperidinyl)-1H-benzimidazole- " N-N NH 87 4-(N-(N'-piperazinyl))amide / \--/ H

3 2-(2-piperidinyl)-I H-benzimidazole- N

N N
H
H
414 2-(2-piperidinyl)- I H-benzimidazole- o 92 4-(N-2-pyrimidinyl)amide N N
H

H
415 2-(2-piperidinyl)-IH-benzimidazole- N 91 4-(N-2-pyridyl)amide N
H

416 2-(2-plperidinyl)-I H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide Ni S H
N_ 2-(2-piperidinyl)- I H-benzimidazole- H N---__X - 417 4-(N-2,4-dihydroxyl-5-pyrimidinyl) HO 88 amide OH

2-(2-piperidinyl)-1H-benzimidazole- H /N-418 4-(N-4,6-dimethoxy-2-pyrimidinyl)a N--\ 93 mide N

cl 2-(2-piperidinyl)-1 H-benzimidazole- H N-419 4-(N-4-chloro-6-amino-2-pyrimidin N-\~ / 89 yI)amide cl 2-(2-piperidinyl)-1 H-benzimidazole- N N_ 420 4-(N-4,6-dichloro-5-pyrimidinyl)am N 93 ide "
cl H H
421 2-(2-piperidinyl)-IH-benzimidazole- N 92 4-(N-o-fluorophenyl)amide 2-(2-piperidinyl)- I H-benzimidazole- H
IH
422 4-(N-2-hydroxyl-4-pyrimidinyl)ami N 86 de /1\
HO"

H IH
423 2-(2-plperidinyl)-IH-benzimidazole- 91 4-(N-6-purinyl)amide ~jl H
OH
H
424 2-(2-plperidinyl)-1H-benzimidazole- " )-__N 89 4-(N-6-hydroxyl-2-purinyl)amide J
H \" H

(L)-2-(3-piperidinyl)-IH-benzimidaz N H OH
425 ole-4-[N-(I-hydroxymethyl-2-p-nitr 93 ophenylhydroxyethyl)]amide "10 HO %" H

(L)-2-(3-piperidinyl)- I H-benzimidaz N I \ H off 426 ole-4-[N-(1-hydroxymethyl-2-p-ami 90 nophenylhydroxyethyl)]am ide HO NH H

H HN N H
427 2-(3-piperidinyl)-l H-benzimidazole- N 90 4-(N-2-piperazinyl)amide "10 H

H N
2-(3-piperidinyl)-IH-benzimidazole- N 94 4-(N-2-pyrimidinyl)amide NH

OZN
(L)-2-(4-piperidinyl)-I H-benzimidaz N I H "
OH
429 ole-4-[N-(1-hydroxymethyl-2-p-nitr / 92 ophenylhydroxyethyl)]amide HO ~" "

HzN H
(L)-2-(4-piperidinyl)-1H-benzimidaz H OH
430 ole-4-[N-(I-hydroxymethyl-2-p-ami 90 noPhenYlhYdroxYethY1)]amide y HO NH H

HN N
431 2-(4-piperidinyl)-IH-benzimidazole- 91 4-(N-2-piperazinyl)amide H
N
432 2-(4-piperidinyl)-I H-benzimidazole- 93 4-(N-2-pyrimidinyl)amide /
N N
H

(L)-2-(3-indolyl)-1H-benzimidazole- NH H OH
433 4-[N-(I-hydroxymethyl-2-p-nitrophe I / H

nylhydroxyethyl)]amide - HO / H

HZN
(L)-2-(3-indolyl)-1H-benzimidazole- NH H H
OH
434 4-[N-(1-hydroxymethyl-2-p-aminop H 88 henylhydroxyethyl)]amide Ho %" H
2-(3-indolyl)-1 H-benzimidazole-4-[ NH c "
435 N-(1-methyl-2-p-chlorophenylhydro H CH3 90 xyethyl)]amide HO NH

NH N 436 2-(3-indolyl)-1H-benzimidazole-4-( H
\" 94 N-N'-piperidinyl)amide H
NH HN N
437 2-(3-indolyl)-]H-benzimidazole-4-( 92 N-2-piperazinyl)amide H
NH N
438 2-(3-indolyl)-]H-benzimidazole-4-( / \ I \ j__L. 90 N-2 benzimidazolyl)amide CN
H

H
439 2-(3-indolyl)-IH-benzimidazole-4-( NH N / \ I 91 N-o-aminophenyl)amide NHZ
H

NH 440 2-(3-indolyl)-1 H-benzimidazole-4-( ()~ >==o 93 N-5-benzimidazolonyl)amide H H

H
2-(3-indolyl)- I H-benzimidazole-4-( NH / "
441 N-4'-carbonamido-5'-imidazolyl)am C5~ H2N N 93 ide "

H
/N
NH N
442 2-(3-indolyl)- I H-benzimidazole-4-( / \ I 88 N-4'-pyrazolyl)amide NH

NH
443 2-(3-indolyl)-111-benzimidazole-4-( N-N NH 89 N-(N'-piperazinyl))amide \-/

N
NH \
444 2-(3-indolyl)-1H-benzimidazole-4-( 94 N-2-pyrazinyl)amide / \ \ /
N
H

NH N
445 2-(3-indolyl)-1H-benzimidazole-4-( N-2-pyrimidinyl)amide / \ \ / 92 N N
H

NH
446 2-(3-indolyl)- I H-benzimidazole-4-( 93 N-2-pyridyl)amide N
H

447 2-(3-indolyl)-l H-benzimidazole-4-( N 91 N-4-m ethyl -5 -th iazo lyl)am ide 6-1-N-2-(3-indolyl)- I H-benzimidazole-4-( NH H
448 N-2,4-dihydroxyl-5-pyrimidinyl)ami Ho \ 87 de N
OH

2-(3-indolyl)-1H-benzimidazole-4-( NH /N-449 N-4,6-dimethoxy-2-pyrimidinyl)ami N /\ / 93 de N

CI
2-(3-indolyl)-1H-benzimidazole-4-( NH N-450 N-4-chloro-6-amino-2-pyrimidinyl)a N-<\ / 88 mide N

CI
NH N-1 2-(3-indolyl)-1H-benzimidazole-4-( N H

451 / \ (\
N /

CI

H

452 2-(3-indolyl)- I H-benzimidazole-4-( NH iiIIIIiIII:
N-o-fluorophenyl)amide NH IH
2-(3-indolyl)-1 H-benzimidazole-4-( 86 453 N-2-hydroxyl-4-pyrimidinyl)amide N

HO N
NH NH
454 2-(3-indolyl)-1H-benzimidazole-4-( C~~ y/ I N 90 N-6-purinyl)amide I\~ J

N N
H

OH
NH
455 2-(3-indolyl)- I H-benzimidazole-4-( N N 86 N-6-hydroxyl-2-purinyl)amide 1 -NN N
H H

(L)-2-(2'-imidazolyl)-I H-benzimida \ H off 456 zole-4-[N-(1-hydroxymethyl-2-p-nit CN
/ - " 93 rophenylhydroxyethyl)]amide N HO %" H

H,N
(L)-2-(2'-imidazolyl)-1 H-benzimida N H OH
457 zole-4-[N-(1-hydroxymethyl-2-p-am I / 93 C >- HO NH
inophenylhydroxyethyl)]amide N H
2-(2'-imidazolyl)-I H-benzimidazole H c I\ H H
C
458 -4-[N-(1-methyl-2-p-chlorophenylhy - CH3 88 droxyethyl)]amide N Ho %"

H
H
459 2-(2'-imidazolyl)-1H-benzimidazole N N N 93 -4-(N-N'-piperidinyl)amide C
N
H HN N
-(2'-imidazolyl)-1H-benzimidazole CN

-4-(N-2-piperazinyl)amide />-N N
H

461 2-(2'-imidazolyl)-IH-benzimidazole cl " I \ \Y"~ 94 -4-(N-2 ' benzimidazolyl)amide N
N H

H
H \ N
462 2-(2'-imidazolyl)-1H-benzimidazole " 86 -4-(N-o-aminophenyl)amide C // I /
N NHZ
H N
463 2-(2'-imidazolyl)-1H-benzimidazole " I

-4-(N-5-benzimidazolonyl)amide C // ~N / H
N H

H
2-(2'-imidazolyl)-1H-benzimidazole H " N
464 -4-(N-4'-carbonamido-5'-imidazolyl I H2N ( N) 86 )amide N H

H
N/N
H
465 2-(2'-imidazolyl)-l H-benzimidazole " I 93 -4-(N-4'-pyrazolyl)amide C
N
NH

466 2-(2'-imidazolyl)-lH-benzimidazole " H-N `NH 93 -4-(N-(N'-piperazinyl))amide C
N
H
467 2-(2'-imidazolyl)-1H-benzimidazole " 94 -4-(N-2-pyrazinyl)amide C
N N
H
H N
468 2-(2'-imidazolyl)-1H-benzimidazole " I 93 -4-(N-2-pyrimidinyl)amide C // NCN/
N H
H
469 2-(2'-imidazolyl)-1H-benzimidazole ~NI D"', -4-(N-2-pyridyl)amide CN
// N N
H

470 2-(2'-imidazolyl)- I H-benzimidazole "
-4-(N-4-methyl-5-thiazolyl)amide 94 I < Ni N_ H N
2-(2'-imidazolyl)-l H-benzimidazole HO 86 471 -4-(N-2,4-dihydroxyl-5-pyrimidinyl) ,~--- \
~~ N
amide N
OH

2-(2'-imidazolyl)-l H-benzimidazole H N-I
472 -4-(N-4,6-dimethoxy-2-pyrimidinyl) N-<\ 94 amide N

Cl H N-473 2-(2 -imidazolyl)-IH-benzimidazole I " H \ 86 -4-(N-4-chloro-6-amino-2-pyrimidin C
yl)amide N NH2 ci 2-(2'-imidazolyl)-IH-benzimidazole H K NCN
-4,6hloro5rimidiny/ N 93 mide N N
ci H
H N
475 2-(2 -imidazolyl)-IH-benzimidazole N 93 -4-(N-o-fluorophenyl)amide C
N
F

2-(2'-imidazolyl)-IH-benzimidazole H NH
C
476 -4-(N-2-hydroxyl-4-pyrimidinyl)ami //
de N
HO \N
H NH
477 2-(2'-imidazolyl)-]H-benzimidazole CN 93 -4-(N-6-purinyl)amide /r N ~jl H
OH
H
478 2-(2'-imidazolyl)-1H-benzimidazole " N N 87 -4-(N-6-hydroxyl-2-purinyl)amide C
N
-NN N
H H

H H
(L)-2-(3-pyrazolyl)-1H-benzimidazo N\ I H OH
479 le-4-[N-(1-hydroxymethyl-2-p-nitro H 94 phenylhydroxyethyl)]amide HO NH H

HZN
H H
(L)-2-(3-pyrazolyl)-1H-benzimidazo "\ I H off 480 le-4-[N-(1-hydroxymethyl-2-p-amin 86 ophenylhydroxyethyl)]amide Ho %" H

H CI I \ "
2-(3-pyrazolyl)-1 H-benzimidazole-4 \ H
481 -[N-(1-methyl-2-p-chlorophenylhydr CH3 90 oxyethyl)]amide Ho NH
2-(3-pyrazolyl)-1 H-benzimidazole-4 " N
482 \" 94 -(N-N'-piperidinyl)amide H /HN N H
483 2-(3-pyrazolyl)-1 H-benzimidazole-4 /N 93 -(N-2-piperazinyl)amide N
H
H N \ N H
484 2-(3-pyrazolyl)-1H-benzimidazole-4 I /N I \Y 93 -(N-2'-benzimidazolyl)amide N
H
H H
485 2-(3-pyrazolyl)-IH-benzimidazole-4 N\N 88 -(N-o-aminophenyl)amide 2-(3-pyrazolyl)-1 H-benzimidazole-4 )::~:N
486 /" >~ 93 -(N-5-benzimidazolonyl)amide N H
H

H
2-(3-pyrazolyl)-1H-benzimidazole-4 487 -(N-4'-carbonamido-5'-imidazolyl)a /" H2N I > 87 N
mide "

H
N NI
488 2-(3-pyrazolyl)- I H-benzimidazole-4 94 -(N-4' -py razo l y l) am i d e NH
H
489 2-(3-pyrazolyl)-1H-benzimidazole-4 N-N
-(N-(N'-piperazinyl))amide \-j NH 86 H\ N
490 2-(3-pyrazolyl)-1H-benzimidazole-4 \
" 90 -(N-2-pyrazinyl)amide N N/
H
H
N N
491 2-(3-pyrazolyl)-1H-benzimidazole-4 86 -(N-2-pyrimidinyl)amide NN-H
H
N N
492 2-(3-pyrazolyl)-IH-benzimidazole-4 I jN 93 -(N-2-pyridyl)amide N
H

N N
493 2-(3-pyrazolyl)-1 H-benzimidazole-4 I ` 93 -(N-4-methyl-5-thiazolyl)amide /N
< Ni S H
H N-2-(3-pyrazolyl)-1H-benzimidazole-4 N---494 -(N-2,4-dihydroxyl-5-pyrimidinyl)a /N HO -\\ 88 mide N
OH

H
2-(3-pyrazolyl)-1H-benzimidazole-4 /N-495 -(N-4,6-dimethoxy-2-pyrimidinyl)a /N N-\ 93 mide N

CI

2-(3-pyrazolyl)-I H-benzimidazole-4 H /N
496 -(N-4-chloro-6-amino-2-pyrimidinyl I /N N-\ 88 )amide N

CI
H
2-(3-pyrazolyl)-1H-benzimidazole-4 "
497 -(N-4,6-dichloro-5-pyrimidinyl)ami I /N (\ / N 94 de N
ci H H
N~
2-(3-pyrazolyl)- I H-benzimidazole-4 " I

-(N-o-fluorophenyl)amide F
H NH
499 2-(3-pyrazolyl)- I H-benzimidazole-4 jN 90 -(N-2-hydroxyl-4-pyrimidinyl)amide N /

HO N
H
IH
2-(3-pyrazolyl)- I H-benzimidazole-4 500 "/ I I 86 -(N-6-purinyl)amide ~N N~
H
OH
H

501 2-(3-pyrazolyl)- I H-benzimidazole-4 I jN N N 89 -(N-6-hydroxyl-2-purinyl)amide ) I /

H H

H
(L)-2-(2-pyrimidinyl)-1 H-benzimida N_ H off 502 zole-4-[N-(I-hydroxymethyl-2-p-nit 93 rophenylhydroxyethyl)]amide N Ho NH H

(L)-2-(2-pyrimidinyl)- I H-benzimida N_ H " off 503 zole-4-[N-(1-hydroxymethyl-2-p-am H 88 inophenylhydroxyethyl)]amide N HO H

CI
2-(2-pyrimidinyl)-]H-benzimidazole N_ H
504 -4-[N-(l-methyl -2-p-chlorophenylhy -4 CH3 93 droxyethyl)]amide N HO %"

H
N
505 2-(2-pyrimidinyl)-1H-benzimidazole N D '-- N
-4-(N-N'-piperidinyl)amide N H

HN N
506 2-(2-pyrimidinyl)-1H-benzimidazole N--4-(N-2-piperazinyl)amide N
N
H
507 2-(2-pyrimidinyl)-1H-benzimidazole ~N-/ "92 -4-(N-2'-benzimidazolyl)amide N N
H

H
508 2-(2-pyrimidinyl)-1H-benzimidazole N N\
-4-(N-o-aminophenyl)amide N aNH2 509 2-(2-pyrimidinyl)-1H-benzimidazole -IN- I N

-4-(N-5-benzimidazolonyl)amide N-% N / CH
H

H
/ N N
2-(2-pyrimidinyl)-1H-benzimidazole N_ 510 -4-(N-4'-carbonamido-5'-imidazolyl ~ H2N 87 N N
)amide H

H
N N
511 2-(2-pyrimidinyl)-1H-benzimidazole N---~ 1 --{ ,) 93 -4-(N-4'-pyrazolyl)amide N
NH

512 2-(2-pyrimidinyl)-IH-benzimidazole ~N -N~NH 88 4-(N-(N'-piperazinyl))amide N~ N

N
513 2-(2-pyrimidinyl)-1 H-benzimidazole N--~\ 93 -4-(N-2-pyrazinyl)amide N N N
H

NI
2-(2-pyrimidinyl)- I H-benzimidazole -4-(N-2-pyrimidinyl)amide N NN
H

_ NI
515 2-(2-pyrimidinyl)-1H-benzimidazole \ 94 -4-(N-2-pyridyl)amide N ' N
H

2-(2-pyrimidinyl)-IH-benzimidazole N-516 -4-(N-4-methyl-5-thiazolyl)amide 93 N
S H
N-2-(2-pyrimidinyl)-1H-benzimidazole N- HO N---_ 517 -4-(N-2,4-dihydroxyl-5-pyrimidinyl) --~\ 90 amide N N
OH

2-(2-pyrimidinyl)-1H-benzimidazole N_ N-518 -4-(N-4,6-dimethoxy-2-pyrimidinyl) N~ N\ 86 amide N

CI

2-(2-pyrimidinyl)-1 H-benzimidazole N_ N-H 519 -4-(N-4-chloro-6-amino-2-pyrimidin 93 ~~ N-<\
yl)amide N

CI
2-(2-pyrimidinyl)-IH-benzimidazole N N
520 -4-(N-4,6-dichloro-5-pyrimidinyl)a\N~ N 93 mide N
cI
H
\
521 2-(2-pyrimidinyl)-1H-benzimidazole N 93 ND -4-(N-o-fluorophenyl)amide N

F

NH
2-(2-pyrimidinyl)-IH-benzimidazole N
522 -4-(N-2-hydroxyl-4-pyrimidinyl)ami 88 de N

HO \N

IH
523 2-(2-pyrimidinyl)-lH-benzimidazole N=

-4-(N-6-purinyl)amide N N

H
OH

524 2-(2-pyrimidinyl)-lH-benzimidazole (/N-~\,\) " N
\, // IX )86 -4-(N-6-hydroxyl-2-purinyl)amide N
H
(L)-2-(2-phenyl-5-pyrimidinyl)-1H- 02" H
525 benzimidazole-4-[N-(1-hydroxymet / H H 90 hyl-2-p-nitrophenylhydroxyethyl)]a ,~ % H H
mide "Z"
(L)-2-(2-phenyl-5-pyrimidinyl)-1H- D-C)- \ H
526 benzimidazole-4-[N-(1-hydroxymet ( / " Off H 90 hyl-2-p-am inophenylhydroxyethyl)] amide "O " "

CI H
2-(2-phenyl-5-pyrimidinyl)-I H-benz "
527 imidazole-4-[N-(1-methyl-2-p-chlor 86 ", ophenylhydroxyethyl)]amide HO % "
2-(2-phenyl-5-pyrimidinyl)- I H-benz D/ - N~
528 imidazole-4-(N-N'-piperidinyl)amid \\ N N 93 e N_ HN N
529 2-(2-phenyl-5-pyrimidinyl)- I H-benz 93 imidazole-4-(N-2-piperazinyl)amide "
N
H

2-(2-phenyl-5-pyrimidinyl)-lH-benz H
530 imidazole-4-(N-2'-benzimidazolyl)a 88 mide N
H

H
2-(2-phenyl-5-pyrimidinyl)-1H-benz / \ \ \ N
531 imidazole-4-(N-o-aminophenyl)ami N / I 93 de NH2 2-(2-phenyl-5-pyrimidinyl)-l H-benz ~/ \\ 7N) "
532 imidazole-4-(N-5-benzimidazolonyl) >== 90 amide H H
H
H
/N N
2-(2-phenyl-5-pyrimidinyl)-IH-benz N
533 imidazole-4-(N-4'-carbonamido-5'-i HZN I 94 N
midazolyl)amide H

H
N~
534 2-(2-phenyl-5-pyrimidinyl)-I H-benz 90 imidazole-4-(N-4'-pyrazolyl)amide "
NH
2-(2-phenyl-5-pyrimidinyl)-1H-benz "
H

535 imidazole-4-(N-(N'-piperazinyl))am N N
ide N
536 2-(2-phenyl-5-pyrimidinyl)-IH-benz / \ \ 86 imidazole-4-(N-2-pyrazinyl)amide N N
H

N
537 2-(2-phenyl-5-pyrimidinyl)-1 H-benz /_\ \ / 93 imidazole-4-(N-2-pyrimidinyl)amide NN/
H

38 2-(2-phenyl-5-pyrimidinyl)-1 H-benz / \ \ / 93 N ji imidazole-4-(N-2-pyridyl)amide /
N
H

2-(2-phenyl-5-pyrimidinyl)-1H-benz n-xo- 539 imidazole-4-(N-4-methyl-5-thiazolyl 88 )amide S H

2-(2-phenyl-5-pyrimidinyl)-1 H-benz \\ N
540 imidazole-4-(N-2,4-dihydroxyl-5-py ~/ N 93 rimidinyl)amide off 2-(2-phenyl-5-pyrimidinyl)- I H-benz N N_ 541 imidazole-4-(N-4,6-dimethoxy-2-py U \`N N 90 rimidinyl)amide N /

CI
2-(2-phenyl-5-pyrimidinyl)-I H-benz \\ --~N N_ 542 imidazole-4-(N-4-chloro-6-amino-2- N H
pyrimidinyl)amide CI
N
2-(2-phenyl-5-pyrimidinyl)-IH-benz N-543 imidazole-4-(N-4,6-dichloro-5-pyri N N 94 midinyl)amide N /
a 2-(2-phenyl-5-pyrimidinyl)-1H-benz N nHi---544 imidazole-4-(N-o-fluorophenyl)amid (::( 90 e F

_ I H
2-(2-phenyl-5-pyrimidinyl)-1 H-benz N
\

545 imidazole-4-(N-2-hydroxyl-4-pyrimi \ / N
dinyl)amide /Ij\
HO"

C~~ N 546 2-(2-phenyl-5-pyrimidinyl)-IH-benz 93 imidazole-4-(N-6-purinyl)amide / "

H
OH
2-(2-phenyl-5-pyrimidinyl)- I H-benz \\-~N
" " 93 D/ - 547 imidazole-4-(N-6-hydroxyl-2-puriny N
1)amide I J
H " H

(L)-2-(4-amino-6-chloro-5-pyrimidi ""' ~" H
548 nyl)-1 H-benzimidazole-4-[N-(1-hyd N- H H 88 Fi 1. roxymethyl-2-p-nitrophenylhydroxy ethyl)]amide CI HO H
N

(L)-2-(4-amino-6-chloro-5-pyrimidi NH2 H2N H
nyl)-lH-benzimidazole-4-[N-(1-hyd N- H off H 93 roxymethyl-2-p-aminophenylhydrox ~ H
yethyl)]amide cl HO H

NH2 cl H
2-(4-amino-6-chloro-5-pyrimidinyl)- H
550 1 H-benzimidazole-4-[N-(l -methyl-2- l\~ / C 90 p-chlorophenylhydroxyethyl)]amide N7~ HO NH
cl 2-(4-amino-6-chloro-5-pyrimidinyl)- N- H
"
551 1H-benzimidazole-4-(N-N'-piperidi 94 nyl)amide cl 2-(4-amino-6-chloro-5-pyrimidinyl)- N-552 1 H-benzim idazole-4-(N-2-piperazin 86 y1)amide N
cl H

2-(4-amino-6-chloro-5-pyrimidinyl)- N- H
553 1 H-benzimidazole-4-(N-2'-benzimid X 90 azolyl)amide H
cl NHZ H
a ~
2-(4-amino-6-chloro-5-pyrimidinyl)- N
554 1H-benzimidazole-4-(N-o-aminophe 86 N
nyl)amide NH2 2-(4-amino-6-chloro-5-pyrimidinyl)- N \ "
555 1 H-benzimidazole-4-(N-5-benzimid N / N~o 93 azolonyl)amide N H H
cl 2-(4-amino-6-chloro-5-pyrimidinyl)- N-I > 556 1H-benzimidazole-4-(N-4'-carbona H2N 86 mido-5'-imidazolyl)amide " H
cl o H

2-(4-amino-6-chloro-5-pyrimidinyl)- N-557 IH-benzimidazole-4-(N-4'-pyrazoly X / 88 I)amide "
cl NH

2-(4-amino-6-chloro-5-pyrimidinyl)- N-558 1 H-benzimidazole-4-(N-(N'-piperaz N-NNH 93 inyl))amide "

2-(4-amino-6-chloro-5-pyrimidinyl)- N
559 1 H-benzimidazole-4-(N-2-pyrazinyl \~ \ 90 )amide H "/

2-(4-amino-6-chloro-5-pyrimidinyl)- N_ N
560 1H-benzimidazole-4-(N-2-pyrimidin \\ / 11 / 90 yl)amide N H "

2-(4-amino-6-chloro-5-pyrimidinyl)- N- N
561 1 H-benzimidazole-4-(N-2-pyridyl)a 1 / 86 mide N
ci H

2-(4-amino-6-chloro-5-pyrimidinyl)- N- N
562 1H-benzimidazole-4-(N-4-methyl-5- l\ / ` 90 thiazolyl)amide \

2-(4-amino-6-chloro-5-pyrimidinyl)- N Ho 563 IH-benzimidazole-4-(N-2,4-dihydro \ 86 N
xyl-5-pyrimidinyl)amide " -c, OH

2-(4-amino-6-chloro-5-pyrimidinyl)- N- N-564 1 H-benzimidazole-4-(N-4,6-dimetho / N\ / 90 xy-2-pyrimidinyl)amide N

CI

2-(4-amino-6-chloro-5-pyrimidinyl)- N- N-565 1 H-benzimidazole-4-(N-4-chloro-6- \\ N~\ 90 N
amino-2-pyrimidinyl)amide N

CI

2-(4-amino-6-chloro-5-pyrimidinyl)- N_ /N
566 IH-benzimidazole-4-(N-4,6-dichlor <\ / N 88 o-5-pyrimidinyl)amide \N
cI

2-(4-amino-6-chloro-5-pyrimidinyl)- N= ",,~
567 1H-benzimidazole-4-(N-o-fluorophe \~ I 93 nyl)amide cl F

2-(4-amino-6-chloro-5-pyrimidinyl)- N- "H
568 1H-benzimidazole-4-(N-2-hydroxyl- \\ / 90 4-pyrimidinyl)amide N N
CI
HO N

2-(4-amino-6-chloro-5-pyrimidinyl)- N-569 1H-benzimidazole-4-(N-6-purinyl)a N N 91 N
mide CI
N H
H

2-(4-amino-6-chloro-5-pyrimidinyl)- N7/- 570 1 H-benzimidazole-4-(N-6-hydroxyl-\\ j Ii 93 2-purinyl)amide N
_ CI H H

(L)-2-(2-pyrrolidine-1-yl-5-pyrimidi N 2" H
. k H OH
571 nyl)-IH-benzimidazole-4-[N-(1-hyd ONK'_ \ --:-) roxymethyl-2-p-nitrophenylhydroxy N
HO NH H
ethyl)]amide (L)-2-(2-pyrrolidine-1-yl-5-pyrimidi N H2N H
nyl)-1 H-benzimidazole-4-[N-(1-hyd ON-~/ H OH H

roxymethyl-2-p-aminophenylhydrox NH
yethyl)]amide HO / H
2-(2-pyrrolidine-1-yl-5-pyrimidinyl) N cl H
573 -IH-benzimidazole-4-[N-(1-methyl- H 94 2-p-chlorophenylhydroxyethyl)]ami N `"' NH
HO /
de 2-(2-pyrrolidine-1-yl-5-pyrimidinyl) cN N H
N 1~1 No 574 -1H-benzimidazole-4-(N-N'-piperidi N 92 nyl)amide H
2-(2-pyrrolidine-l-yl-5-pyrimidinyl) CN~N HN )-575 -1H-benzimidazole-4-(N-2-piperazin N 94 yl)amide H
2-(2-pyrrolidine-l-yl-5-pyrimidinyl) CN /N~ I \ H
576 -IH-benzimidazole-4-(N-2'-benzimi N- 94 dazolyl)amide H
2-(2-pyrrolidine-l-yl-5-pyrimidinyl) CN_ 577 -1H-benzimidazole-4-(N-o-aminoph enyl)amide I / NH 2 2-(2-pyrrolidine-1-yl-5-pyrimidinYl) IN- N :::\: \ C "
578 -1 H-benzimidazole-4-(N-5-benzimid N I ~ 90 azolonyl)amide H H H

H
2-(2-pyrrolidine-1-yl-5-pyrimidinyl) N \ /N \ N
579 -1H-benzimidazole-4-(N-4'-carbons CN N HZN I 85 N
mido-5'-imidazolyl)amide H

H

2-(2-pyrrolidine-1-yl-5-pyrimidinYl) N N580 -1 H-benzimidazole-4-(N-4'-pyrazol cN N~ 93 yl)amide NH
2-(2-pyrrolidine-I-yl-5-pyrimidinYl) CN N:)\
581 -IH-benzimidazole-4-(N-(N'-pipers NN-N~NH 93 zinyl))amide N::
2-(2-pyrrolidine-l-yl-5-pyrimidinyl) cN \
582 -1 H-benzim idazole-4-(N-2-pyraziny N 88 1)amide H
2-(2-pyrrolidine-I-yl-5-pyrimidinyl) N N c::)\ N
583 -IH-benzimidazole-4-(N-2-pyrimidi N 89 n 1 amide NN
Y) H

2-(2-pyrrolidine-l-yl-5-pyrimidinyl) cN j~ N
584 -1 H-benzimidazole-4-(N-2-pyridyl)a N 87 mide H /
2-(2-pyrrolidine-1-yl-5-pyrimidinyl) CN~N~ N cH3 585 -1H-benzimidazole-4-(N-4-methyl-5 N- 92 -thiazolyl)amide s H~

N y H
2-(2-pyrrolidine-l-yl-5-pyrimidinyl) CN-~/ \~ HON 90 586 -1H-benzimidazole-4-(N-2,4-dihydr N- \\\\
oxyl-5-pyrimidinyl)amide N
OH

2-(2-pyrrolidine-1-yl-5-pyrimidinyl) N N
C ~
- /N-587 -IH-benzimidazole-4-(N-4,6-dimeth N N-\ ~H3 oxy-2-pyrimidinyl)amide CI
2-(2-pyrrolidine-1-yi-5-pyrimidinyl) N N N-H
C
588 -l H-benzimidazole-4-(N-4-chloro-6- N N
<\ / 93 amino-2-pyrimidinyl)amide "

2-(2-pyrrolidine-1-yl-5-pyrimidinyl) CN N-\ N_ Cl 589 -1H-benzimidazole-4-(N-4,6-dichlor N ( / N~ 93 o-5-pyrimidinyl)amide 2-(2-pyrrolidine-1-yl-5-pyrimidinyl) N
CN-~ \ N\
590 -1H-benzimidazole-4-(N-o-fluoroph N- 94 enyl)amide 2-(2-pyrrolidine-1-yl-5-pyrimidinyl) C ~N \ IH
N
591 -1Hbenzimidazole-4-(N-2-hydroxyl N 90 -4-pyrimidinyl)amide /JIB
HO" N
2-(2-pyrrolidine-1-yl-5-pyrimidinyl) N \ I"
N
592 -1H-benzimidazole-4-(N-6-purinyl)a N- N 93 mide x:'j, H

OH
2-(2-pyrrolidine-I-yl-5-pyrimidinyl) /j 593 -1H-benzimidazole-4-(N-6-hydroxyl CNC C N~ N 92 -2-purinyl)amide -N H \N H
(L)-2-(2-piperidine-1-yl-5-pyrimidin N O2N H
594 yl)-1H-benzimidazole-4-[N-(l-hydr CN N~ H off H 91 oxymethyl-2-p-nitrophenylhydroxye HO NH H
thyl)]amide (L)-2-(2-piperidine-1-yi-5-pyrimidin N HZN H
595 yl)-IH-benzimidazole-4-[N-(1-hydr CN-rr:-) / H OH H 91 oxymethyl-2-p-am inophenylhydroxy NH
ethyl)]amide HO H
2-( 2- i eridine-1- I-5- rimidin I -1 cl \ H
-( PP Y PY Y) CN N I H
596 H-benzimidazole-4-[N-(I-methyl-2-p N- CH3 93 -chlorophenylhydroxyethyl)]amide HO NH

H
2-(2-piperidine-1-yl-5-pyrimidinyl)- CNj N\N
597 1 H-benzimidazole-4-(N-N'-piperidi N-~ 92 nyl)amide ,~N) 2-(2-piperidine-1-yl-5-pyrimidinyl)- CN N HN H
598 1 H-benzimidazole-4-(N-2-piperazin N 93 yl)amide H
2-(2-piperidine-l-yl- (pyrimidinyl)- CN j- N
H
599 1H-benzimidazole-4- N-2'-benzimid N 94 azolyl)amide H
2-(2-piperidine-l-yl-5-pyrimidinyl)- H
CN~ -\ ~\ N
600 1 H-benzimidazole-4-(N-o-aminophe N II I 92 IH, nyl)amide 2-(2-piperidine-l-yl-5--pyrimidinyl)- CNN )::~: N
601 1H-benzimidazole-4- `-5-benzimid NC 92 azolonyl)amide H H

H
N
2-(2-piperidine-l-yl-5-pyrimidinyl)- N
HzN 85 602 1 H-benzimidazole-4-(N-4'-carbons NNN:~\-N
mido-5'-imidazolyl)amide H

H
2-(2-piperidine-I-yl-5-pyrimidinyl)- \ NON
CNN- /
603 1 H-benzimidazole-4-(N-4'-pyrazoly 94 I)amide NH\
2-(2-piperidine-1-yl-5-pyrimidinyl)- CN N
604 1 H-benzimidazole-4-(N-(N'-piperaz N N- ~~ " 90 inyl))amide 2-(2-piperidine-I-yl-5-pyrimidinyl)- NN N
) 605 1 H-benzimidazole-4-(N-2-pyrazinyl N~ 94 )amide H N

2-(2-piperidine-I-yl-5-pyrimidinyl)- N N \
N \
606 1 H-benzimidazole-4-(N-2-pyrimidin N / 92 yl)amide H
"
2-(2-piperidine-1-yl-5-pyrimidinyl)- CN N >:\
//
607 1 H-benzimidazole-4-(N-2-pyridyl)a N94 mide H
2-(2-piperidine-l-yl-5-pyrimidinyl)- N CH, 608 1H-benzimidazole-4-(N-4-methyl-5- CN N~ 94 thiazolyl)amide S H
2-(2-piperidine-l-yl-5-pyrimidinyl)- CNN H0 N N_ 609 1 H-benzimidazole-4-(N-2,4-dihydro N \ 93 xyl-5-pyrimidinyl)amide OH

OCH, 2-(2-piperidine-1-yl-5-pyrimidinyl)- N G:y N N610 1 H-benzimidazole-4-(N-4,6-dimetho N H
xy-2-pyrimidinyl)amide " /

cl 2-(2-piperidine-I-yl-5-pyrimidinyl)- N
N
"
611 1H-benzimidazole-4-(N-4-chloro-6- N 91 "--~
amino-2-pyrimidinyl)amide cl 2-(2-piperidine-I-yl-5-pyrimidinyl)- CN N
N- (\/~ N
612 I H-benzimidazole-4-(N-4,6-dichlor 93 o-5-pyrimidinyl)amide cl CN 2-(2-piperidine-1-yi-5-pyrimidinyl)- N H
"\
613 1 H-benzim idazole-4-(N-o-fluorophe N- 93 :: aF

nyl)amide 2-(2-piperidine-I-yl-5-pyrimidinyl)- N -\ I"

614 1H-benzimidazole-4-(N-2-hydroxyl- CN N N, 88 4-pyrimidinyl)amide HON
2-(2-piperidine-I-yl-5-pyrimidinyl)-615 1 H-benzimidazole-4-(N-6-purinyl)a N- 89 N i N
mide N N
H

2-(2-piperidine-I-yl-5-pyrimidinyl)- CN~N_/ ~H
616 1H-benzimidazole-4-(N-6-hydroxyl- N 87 2-purinyl)amide H H

(L)-2-(2-cyclopropylamino-5-pyrimi N 2" H
617 dinyl)-IH-benzimidazole-4-[N-(1-hy D-NH-~ / H OH

droxymethyl-2-p-nitrophenylhydrox N- H
yethyl)]amide H NH H
(L)-2-(2-cyclopropylamino-5-pyrimi N H2N \ H
618 dinyl)-1 H-benzimidazole-4-[N-(1-hy >-NH-{~ I / H H N H 90 droxymethyl-2-p-aminophenylhydro NH
xyethyl)]amide HO / H
2-(2-cyclopropylamino-5-pyrimidin N G H
yl)-l H-benzimidazole-4-[N-(1-meth >-NH H

1-2-chloro hen lh drox eth l a `"' YP- P Y Y Y Y )J NH
mide HO /

H
2-(2-cyclopropylamino-5-pyrimidin >- NH-~N N
'- N
620 yl)-1H-benzimidazole-4-(N-N'-piper N 93 idinyl)amide N ~ HN NH--C _(N) 2-(2-cyclopropylamino-5-pyrimidin 621 yl)-1 H-benzimidazole-4-(N-2-pipera N 93 zinyl)amide H
2-(2-cyclopropylamino-5-pyrimidin > NH. N N
622 yl)-l H-benzimidazole-4-(N-2'-benzi V N- I >' 94 midazolyl)amide H
H
2-(2-cyclopropylamino-5-pyrimidin N N
D- NH-623 yl)-1 H-benzimidazole-4-(N-o-amino N- 90 phenyl)amide NHi 2-(2-cyclopropylamino-5-pyrimidin N H
D-NH-~
624 yl)-1H-benzimidazole-4-(N-5-benzi N- ):: ~ 93 midazolonyl)amide H H
2-(2-cyclopropylam ino-5-pyrimidin N-\ N
-625 yt)-1 H-benzimidazole-4-(N-4'-carbo ~ NH N H2N 92 N
namido-5'-imidazolyl)amide H

H
N---N
2-(2-cyclopropylamino-5-pyrimidin 1> N NH
626 yl)-l H-benzimidazole-4-(N-4'-pyraz ~ - I / 91 olyl)amide NH
2-(2-cyclopropylamino-5-pyrimidin N
>-NH-~

627 yl)-1H-benzimidazole-4-(N-(N'-pipe N- NH
razinyl))amide ll N
2-(2-cyclopropylamino-5-pyrimidin NH
628 yl)-IH-benzimidazole-4-(N-2-pyrazi N~- 93 nyl)amide H "

2-(2-cyclopropylamino-5-pyrimidin NH /N \ N \
629 yl)-IH-benzimidazole-4-(N-2-pyrim N~ 92 idinyl)amide H "
2-(2-cyclopropylamino-5-pyrimidin NH /j \ N
630 yl)-1 H-benzimidazole-4-(N-2-pyridy )III1J / 93 N
I)amide H
2-(2-cyclopropylamino-5-pyrimidin \ N cH, 631 yl)-IH-benzimidazole-4-(N-4-methy 94 N- /~
1-5-thiazolyl)amide \s H~

Ho 2-(2-cyclopropylamino-5-pyrimidin NH /N ( 632 yl)-lH-benzimidazole-4-(N-2,4-dihy \\N 92 droxyl-5-pyrimidinyl)amide off 2-(2-cyclopropylamino-5-pyrimidin \NH- H
\ N-N
633 yi)-1 H-benzimidazole-4-(N-4,6-dim N- NN 92 ethoxy-2-pyrimidinyl)amide CI
2-(2-cyclopropylamino-5-pyrimidin N NFf \ N-634 yl)-lH-benzimidazole-4-(N-4-chloro N- N---~ / 93 -6-amino-2-pyrimidinyl)amide ~~"
NHZ
2-(2-cyclopropylamino-5-pyrimidin "
(\ NH- \ -635 yl)-l H-benzimidazole-4-(N-4,6-dich 1~ N N 94 Toro-5-pyrimidiny1)amide \
CI

2-(2-cyclopropylamino-5-pyrimidin N \ H
>-NH--C
636 yl)-lH-benzimidazole-4-(N-o-fluoro N- 90 phenyl)amide F
2-(2-cyclopropylamino-5-pyrimidin N \ IH
NH--{
637 yl)-1 H-benzimidazole-4-(N-2-hydro N- 94 xyl-4-pyrimidinyl)amide N

HON

2-(2-cyclopropylamino-5-pyrimidin j iH
638 yl)-]H-benzimidazole-4-(N-6-puriny D- NH--C N N IN 92 1)amide ~N N
H
OH
2-(2-cyclopropylamino-5-pyrimidin N -- N N
639 yl)-1 H-benzimidazole-4-(N-6-hydro D- NH N 94 xyl-2-purinyl)amide -N N N
H H

(L)-2-(1,3-dimethyl-5-chloro-4-pyra Ci CH3 OyN H
640 zolyl)-1H-benzimidazole-4-[N-(1-hy N H OH H 94 droxymethyl-2-p-nitrophenylhydrox NH
yethyl)]amide CH3 Ho H
(L)-2-(1,3-dimethyl-5-chloro-4-pyra Cl CH3 HzN H
641 zolyl)-1H-benzimidazole-4-[N-(1-hy N I / H OH

droxymethyl-2-p-am inophenylhydro CH3 HO % H H
xyethyl)]amide `I H
2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 642 1)-1 H-benzimidazole-4-[N-(] -methyl -2-p-chlorophenylhydroxyethyl)]ami "' HO NH
de CH3 2-(1,3-dimethyl-5-chloro-4-pyrazoly N /N"-N
643 1)- 1 H-benzimidazole-4-(N-N'-piperi C~N 91 dinyl)amide CH3 2-(l,3-dim ethyl-5-chloro-4-pyrazoly N CH3 HN H
644 1)- 1 H-benzimidazole-4-(N-2-piperaz N ~N) 93 inyl)amide CH3 H
2-(1,3-dimethyl -5-chloro-4-pyrazoly CI C}{, N H
645 l)-IH-benzimidazole-4-(N-2'-benzi N N_~ 93 midazolyl)amide CH3 H

H
2-(1,3-dimethyl-5-chloro4-pyrazoly cl CH, N
646 1)-IH-benzimidazole-4-(N-o-aminop N 88 henyl)amide CH3 NHy CI CH3 2-(1,3-dimethyl -5-chloro4-pyrazoly ):)_H
647 1)- 1 H-benzimidazole-4-(N-5-benzim N 89 idazolonyl)amide cH3 H "

H
N
2-(1,3-dimethyl-5-chloro-4-pyrazoly CI N CH, "
648 I)-1H-benzimidazole-4-(N-4'-carbon N HzN I N~ 87 amido-5'-imidazolyl)amide cH3 H

H
2-(1,3-dimethyl-5-chloro-4-pyrazoly cl N cH3 "~
649 I)-1H-benzimidazole-4-(N-4'-pyrazo N I / 92 lyl)amide CH3 NH
2-(1,3-dimethyl-5-chloro-4-pyrazoly CI CH3 650 1)-1 H-benzimidazole-4-(N-(N'-piper N- `~NH 90 azinyl))amide cH3 2-(1,3-dimethyl -5-chloro-4-pyrazoly cl cH3 "\
651 1)-1 H-benzimidazole-4-(N-2-pyrazin N I / 91 yl)amide CH3 H "

CI
2-(l,3-dimethyl -5-chloro-4-pyrazoly CH3 N " \
652 1)-I H-benzimidazole-4-(N-2-pyrimi N 93 dinyl)amide CH3 H N

CI
2-(l,3-dim ethyl -5-chloro-4-pyrazoly CH3 N " \
653 I)-IH-benzimidazole-4-(N-2-pyridyl N 93 )amide CH3 H

CI
2-(1,3-dimethyl-5-chloro-4-pyrazoly N CH3 N cH, 654 1)- 1 H-benzi m idazole-4-(N-4-m ethyl - ;\N 94 5-thiazolyl)amide CH3 s H~

Cl CH3 N H
2-(1,3-dimethyl-5-chloro-4-pyrazoly N`
655 1)- 1 H-benzimidazole-4-(N-2,4-dihyd ;IN HO \ 90 N
roxyl-5-pyrimidinyl)amide CH3 off Ci 2-(1,3-dimethyl-5-chloro-4-pyrazoly cH3 N_ 656 1)- 1 H-benzimidazole-4-(N-4,6-dimet ;\N 93 hoxy-2-pyrimidinyl)amide "
CH, OCH3 CH3 N_ CI
2-(1,3-dimethyl-5-chloro-4-pyrazoly ;kN 657 1)-1H-benzimidazole-4-(N-4-chloro-/N_- \ 92 6-amino-2-pyrimidinyl)amide CH3 C' CI
2-(1,3-dimethyl-5-chloro-4-pyrazoly N CH3 658 1)-1H-benzimidazole-4-(N-4,6-dichl N N 91 oro-5-pyrimidinyl)amide "
C1j3 CI

2-(1,3-dim ethyl -5-chloro-4-pyrazoly Y N
659 1)- 1 H-benzimidazole-4-(N-o-fluorop N 91 henyl)amide cti3 Cl CH3 H
2-(1,3-dimethyl-5-chloro-4-pyrazoly 660 1)-1H-benzimidazole-4-(N-2-hydrox 93 yi-4-pyrimidinyl)amide 03 "

HON
CI IH
2-(1,3-dimethyl-5-chloro-4-pyrazoly CH3 N
661 1)-IH-benzimidazole-4-(N-6-purinyl N N N 92 )amide CH, H
OH
CI
2-(1,3-dimethyl-5-chloro-4-pyrazoly CH3 662 1)- 1 H-benzimidazole-4-(N-6-hydrox ;\N "/ I'Ij 93 yl-2-purinyl)amide CH3 _ N N N/
H H
F
663 2-(4-hydroxyphenyl)-1 H-benzimIda OH 94 zole-4-(N-o-fluorophenyl)amide \ / \ /

OZN
(L)-2-(3-hydroxyphenyl)-1 H-benzim H OH
664 idazole-4-[N-(1-hydroxymethyl-2-p- 92 nitrophenylhydroxyethyl)]amide OH HO NH H

OH
-2-(3-hydroxyphenyl)- I H-benzimida 665 zole-4-(N-6-hydroxyl-2-purinyl)ami LJ!IiIi3 92 de OH
_ H N H
Structure Identification of Product (refer to Figures 3-6):
(23)2-(2-pyridyl)-1H-benzimidazole-4-N-hydroxyethylamide 'HNMR (DMSO, 400MHz) 6: 3.64-3.67(t,IH), 3.73-3.75(m,2H), 4.39-4.42(t,2H), 7.32-7.36(t, I H), 7.38-7.40(t, ] H), 7.73-7.75(d,1 H), 7.80-7.8 1(d, l H), 7.85-7.86(t,1 H), 8.38-8.40(d,IH), 8.59-8.61(d,1H);
(24) 2-(2-pyridyl)-1H-benzimidazole-4-N-o-hydroxyphenylcarboxylamide 'HNMR (DMSO, 400MHz) b: 5.35(s,IH), 7.13(s,IH), 7.15-7.16(d,2H), 7.34-7.36(t,3H), 7.37-7.39(t, I H), 7.83-7.84(d, I H), 7.85-7.86(t, I H), 7.91 -7.92(d, ] H), 8.11-8.1 2(d, I H), 8.38-8.40(d,1 H), 8.59-8.61(d,1 H);
(25) 2-(2-hydroxyphenyl)-lH-benzimidazole-4-(N-o-fluorophenyl)amide i 1-INMR (DMSO, 400MHz) 8: 5.35(s,1 H), 6.59-6.61(d, l H), 6.63-6.64(t, I H), 6.95-6.97(t,1 H), 6.99-7.00(d, l H), 7.01 -7.02(d, l H), 7.07-7.09(t, I H), 7.24-7.25(t, l H), 7.37-7.39(t,1 H), 7.62-7.63(d,I H), 7.83-7.84(d, I H), 7.91 -7.92(d, l H);
(26)(L)-2-(2-hydroxyphenyl)-1 H-benzimidazole-4-[N-(1-hydroxyl-2-p-nitrophenylhydr oxyethyl)]amide 'HNMR (DMSO, 400MHz) S: 3.17-3.18(m,1 H), 3.25-3.28(m, I H), 3.50-3.52(m, I
H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 5.35(s,I H), 7.01-7.02(d, I H), 7.07-7.09(t, I H), 7.24-7.25(d, l H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.66-7.67(d,1 H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 8.17-8.20(d,2H) ;
(27)2-(5-nitro-2-th ienyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide ' HNMR (DMSO, 400MHz) 6: 7.43-7.46(t, l H), 7.70-7.72(d, ] H), 7.89-7.91(d, I
H), 7.93-7.95(d, I H), 8.30-8.33(d, I H), 8.57-8.60(d, l H), 11 .53(s, I H);
(28)2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide(refer to Figure 3) ' HNMR(DMSO,400MHz)6:7.13-7.19(m, I H),7.23-7.27(t, I H),7.36-7.41 (t, I
H),7.50-7.5 4(m,2H), 7.85-7.87(d, ] H), 7.94-7.95(d, I H), 8.05-8.07(d, I H), 8.57-8.61 (t, I H), 12.1 9-12.20(d,1 H), 14.25(s,1 H);

(29)2-(3,4,5-trihyd roxyphenyl)-1 H-benzim id azole-4-(N-o-fluorophenyl)a mide 'HNMR (DMSO, 400MHz) 8: 5.33(s,IH), 5.35(s,IH), 5.38(s,IH), 6.59-6.61(d,IH), 6.63-6.64(t, I H), 6.71 (s,2H), 6.95-6.97(t, I H), 6.99-7.01 (d, I H), 7.43-7.45(t, l H), 7.90-7.91(d, I H), 7.93-7.94(d, l H);
(30)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-hydroxyethyl)amide 'HNMR (DMSO, 400MHz) 6: 5.33(s,1H), 5.35(s,IH), 5.38(s,IH), 2.84-2.88(m,2H), 3.59-3.62(m,2H), 3.65-3.67(t,1 H), 6.71(s,2H), 7.43-7.45(t, l H), 7.89-7.90 (d,1 H), 7.93-7.94(d, I H);
(31)2-(2-piperidinyl)-1H-benzimidazole-4-(4-N'-ethyl-N-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.02-1.05(t,3H), 1.43-1.44(m,1H), 1.45-1.47(m,1H), 1.49-1.52(m,IH), 1.55-1.57(m,IH), 1.67-1.69(mIH), 1.91-1.94(m,IH), 2.38-2.40(m,2H), 2.50-2.52(t,4H), 2.65-2.67(t,4H), 2.69-2.72(m, I H), 2.79-2.81 (m, l H), 4.02-4.04(m, l H), 7.43-7.45(t, I H), 7.90-7.91 (d, I H), 7.93-7.94(d, I H);
(32)2-(2-pyridyl)-1 H-benzimidazole-4-(4-N'-ethyl-N-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.02-1.05(t,3H), 2.38-2.40(m,2H), 2.50-2.52(t,4H), 2.65-2.67(t,4H), 7.36-7.38(t,H), 7.43-7.45(t, l H), 7.85-7.86(t, I H), 7.90-7.91 (d, I H), 7.93-7.94(d, I H), 8.38-8.39(d, I H), 8.59-8.61(d, l H);
(33)(L)-2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nit rophenylhydroxyethyl)] amide ' HNMR (DMSO, 400MHz) 6: 1.70(s, I H), 1.82(s, I H), 1.85(s, I H), 2.00-2.06(t,4H), 3.17-3.1 8(m, I H), 3.19-3.20(d,1 H), 3.25-3.28(m, I H), 3.50-3.52(m, l H), 3.65-3.68(t, I H), 3.70-3.72(d, l H), 4.73-4.77(t, l H), 5.13-5.1 5(t, l H), 5.20-5.23(t, l H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, I H), 7.93-7.95(d, l H), 8.17-8.20(d,2H);
(34)(L)-2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-am inophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 1.70(s,1 H), 1.82(s, I H), 1.85(s, I H), 2.00-2.06(t,4H), 3.17-3.1 8(m, I H), 3.1 9-3.20(d, I H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3.65-3.68(t,1 H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 5.13-5.15(t, I H), 5.20-5.23(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d, I H);

(35)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhy droxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.70(s,IH), 1.82(s,IH), 1.85(s,IH), 2.00-2.06(t,4H), 3.1 9-3.20(d, I H), 3.25-3 .28(m, l H), 3.65-3 .68(t, l H), 4.73-4.77(t, I H), 5.13-5.1 5(t, I H), 5.20-5.23(t, I H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, l H), 7.89-7.91(d, I H), 7.93-7.94(d, I H);
(36) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), I.70(s,IH), I .82(s, I H), I .85(s, l H), 2.00-2.06(t,4H), 3.10-3.15(t,4H), 3. 19-3.20(d, l H), 5.13-5.1 5 (t, I H), 5.20-5.23(t, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(37) 2-(2,6-dimethyl-2,6-octadienyl)-IH-benzimidazole-4-(N- 2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.70(s, I H), 1.82(s, l H), 1.85(s, l H), 1.91-1.93(m,2H), 2.00-2.06(t,4H), 2.62-2.63(m, I H), 2.65-2.66(m, I H), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.77-2.80(m,1 H), 3.02-3.05(m, l H), 3.1 9-3.20(d, l H), 3.99-4.01(m, l H), 5.13-5.1 5(t, I H), 5.20-5.23(t,IH), 7.43-7.45(t,IH), 7.89-7.91(d,lH), 7.93-7.94(d,1H);
(38) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide ' HNMR (DMSO, 400MHz) S: 1.70(s, l H), 1.82(s, I H), 1.85(s, l H), 2.00-2.06(t,4H), 3.1 9-3.20(d, I H), 5.13-5.1 5(t, I H), 5.20-5 .23(t, I H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H);
(39) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide ' HNMR (DMSO, 400MHz) 8: 1.70(s, l H), 1.82(s, I H), 1.85(s, I H), 2.00-2.06(t,4H), 3.1 9-3.20(d, l H), 5.13-5.15(t, I H), 5.20-5.23(t, I H), 6.27(s,2H), 6.38-6.40(d, l H), 6.56-6.58(t, I H), 6.75-6.76(d, I H), 7.02-7.04(t, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(40) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide ' HNMR (DMSO, 400MHz) 6: 1.70(s,1 H), 1.82(s, I H), 1.85(s, l H), 2.00-2.06(t,4H), 3.19-3.20(d,1 H), 5.13-5.15(t,1 H), 5.20-5.23(t, I H), 6.35-6.37(d, I H), 6.93(s, I H), 7.43-7.45(t, I H), 7.54-7.56(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);
(41)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl )amide 'HNMR (DMSO, 400MHz) 6: 1.70(s, I H), 1.82(s,1 H), 1.85(s, l H), 2.00-2.06(t,4H), 3. 19-3.20(d, l H), 5.13-5.1 5(t, l H), 5.20-5.23(t, l H), 7.43-7.45(t, IH), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.37(s,2H), 9.24-9.26(d, I H), 13.00-1 3.03(d, I H);
(42)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzi m idazole-4-(N-4'-pyrazolyl)am ide ' HNMR (DMSO, 400MHz) 6: 1.70(s,1 H), I.82(s, l H), 1.85(s, I H), 2.00-2.06(t,4H), 3.1 9-3.20(d, l H), 5.13-5.1 5(t, l H), 5.20-5.23(t, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d,1H), 8.61(s,IH), 8.63-8.65(d,IH), 13.71-13.75(d,IH);
(43)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-(N'-piperazi nyl))amide ' HNMR (DMSO, 400MHz) 6: 1 .70(s, I H), I .82(s, I H), I .85(s, I H), 1.91-1 .95(m, I H), 2.00-2.06(t,4H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.1 9-3.20(d, l H), 5.13-5.1 5(t, I H), 5.20-5.23(t, l H), 7.43-7.45(t, I H), 7.90-7.91 (d, I H), 7.93-7.94(d, l H);
(44)2-(2,6-dim ethyl-2,6-octadienyl)-1 H-benzimid azole-4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.70(s,1 H), 1.82(s, I H), 1.85(s, I H), 2.00-2.06(t,4H), 3. 19-3.20(d, l H), 5.13-5.1 5(t, I H), 5.20-5.23(1, ]H), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, ] H), 8.34-8.35(d,I H), 8.36(s,I H), 8.40-8.42(d,1 H);
(45)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.70(s, l H), 1.82(s, I H), 1.85(s, l H), 2.00-2.06(t,4H), 3.1 9-3.20(d, l H), 5.13-5.1 5(t, I H), 5.20-5.23(t, I H), 6.93-6.95(t, I H), 7.43-7.45(t, l H), 7.89-7.91(d,IH), 7.93-7.94(d,IH), 8.45-8.46(d,2H);
(46)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 8: 1.70(s, I H), 1.82(s, l H), 1.85(s, I H), 2.00-2.06(t,4H), 3.1 9-3.20(d, l H), 5.13-5.1 5(t, l H), 5.20-5.23(t,I H), 6.62-6.64(t, l H), 6.70-6.72(d, I H), 7.43-7.45(t, I H), 7.55-7.57(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.07-8.09(d, I H);
(47)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.70(s, I H), 1.82(s, I H), 1.85(s,1 H), 2.00-2.06(t,4H), 2.45(s,3H), 3.19-3.20(d,I H), 5.13-5.1 5(t, l H), 5.20-5.23(t, I H), 7.43-7.45(t, l H), 7.89-7.91(d,IH), 7.93-7.94(d,IH), 8.12(s,IH);
(48)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidi nyl) amide ' HNMR (DMSO, 400MHz) 6: 1 .70(s, ] H), I.82(s,1 H), 1.85(s,1 H), 2.00-2.06(t,4H), 3.19-3.20(d, I H), 5.13-5.15(t, I H), 5.20-5.23(t, l H), 7.43-7.45(t, l H), 7.82(s, I H), 7.89-7.9 1(d, l H), 7.93-7.94(d, I H), 8.33(s, I H), 11 .53(s, l H);
(49)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl) amide ' HNMR (DMSO, 400MHz) 6: 1.70(s, l H), I.82(s, I H), 1.85(s,1 H), 2.00-2.06(t,4H), 3.1 9-3.20(d, I H), 3.82(s,6H), 5.13-5.1 5(t, l H), 5.20-5 .23(t, l H), 5.71 (s, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H) ;
(50)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidin yl)amide ' HNMR (DMSO, 400MHz) 6: 1.70(s, l H), 1.82(s,1 H), 1.85(s, l H), 2.00-2.06(t,4H), 3.19-3.20(d,I H), 5.13-5.1 5(t, I H), 5.20-5.23(t, I H), 5.98(s, I H), 7.43-7.45(t, l H), 7.74(s,2H), 7.89-7.91(d, I H), 7.93-7.94(d, I H);
(51)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)a mide 'HNMR (DM SO, 400MHz) S: 1.70(s, l H), 1.82(s, l H), 1.85(s, l H), 2.00-2.06(t,4H), 3.1 9-3.20(d, ] H), 5.1 3-5.15(t, I H), 5.20-5.23(t,1 H), 7.43-7.45(t,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 9.34(s, I H);
(52)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 8: 1.70(s,IH), 1.82(s,IH), 1.85(s,IH), 2.00-2.06(t,4H), 3.19-3.20(d,1 H), 5.13-5.1 5(t, l H), 5.20-5.23(t, I H), 6.60-6.61(d, I H), 6.63-6.65(t,1 H), 6.96-6.98(t, IH), 6.99-7.01 (d, I H), 7.43-7.45(t, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, l H) ;
(53)2-(2,6-(Iimethyl-2,6-octadienyl}1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)ami de ' HNMR (DMSO, 400MHz) 6: 1.70(s, l H), 1.82(s, l H), 1.85(s, I H), 2.00-2.06(t,4H), 3.19-3.20(d,1 H), 5.13-5.1 5(t, I H), 5.20-5.23(t, I H), 5.46-5.48(d, l H), 7.10-7.11 (d, l H), 7.43-7.45(t, I H), 7.82(s, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);
(54)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.70(s, I H), 1.82(s, l H), 1.85(s, l H), 2.00-2.06(t,4H), 3.19-3.20(d, I H), 5.13-5.1 5(t, l H), 5.20-5.23(t, l H), 7.43-7.45(t, I H), 7.86-7.88(d,1 H), 7.89-7.91(d, l H), 7.93-7.94(d, l H), 8.16-8.1 8(d, l H) ;
(55)2-(2,6-dimethyl-2,6-octadienyl)-1 H-benzimidazole-4-(N-6-hydroxy-2-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.70(s, I H), 1.82(s,1 H), 1.85(s, I H), 2.00-2.06(t,4H), 3.1 9-3.20(d, l H), 5.13-5.1 5(t, l H), 5.20-5.23(t, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d,1H), 8.57-8.59(d,IH), 11.53(s,IH);
(56)(L)-2-(2-thienyl)-lH-benzimidzzole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyet hyl)]amide ' HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m, I
H), 3 .65-3.68(t, I H), 3.70-3.72(d,1 H), 4.73-4.77(t, l H), 7.17-7.1 9(t, I H), 7.43-7.45(t, I H), 7.62-7.65(d,2H), 7.69-7.71 (d, I H), 7. 85-7.87(d, I H), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 8.17-8.20(d,2H);
(57)(L)-2-(2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhyd roxy ethyl)]amide ' HNMR (DMSO, 400MHz) 8: 3.17-3.1 8(m, I H), 3.25-3.28(m,1 H), 3.50-3.52(m,1 H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, l H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.17-7.1 9(t, I H), 7.43-7.45(t, l H), 7.69-7.71 (d, I H), 7.85-7.87(d, I H), 7.89-7.90(d,1 H), 7.93-7.95(d,1 H);
(58)2-(2-thienyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) 8: 1.12-1.15(d,3H), 3.25-3.28(m,]H), 3.65-3.68(t,IH), 4.73-4.77(1,1 H), 7.17-7.1 9(t, I H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, l H), 7.69-7.71 (d, I H), 7.85-7.87(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H) ;
(59)2-(2- thienyl)-IH-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.17-7.1 9(1, I H), 7.43-7.45(t, I H), 7.69-7.71 (d, I H), 7.85-7.87(d, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);
(60)2-(2- thienyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,IH), 2 .69-2.70(m, l H), 2.72-2.74(m, I H), 2.77-2.80(m, I H), 3.02-3.05(m, I H), 3.99-4.01 (m, l H), 7.17-7.1 9(t, l H), 7.43-7.45(t, I H), 7.69-7.71 (d, I H), 7.85-7.87(d, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H);
(61)2-(2- thienyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.12-7.15(d,2H), 7.1 7-7.19(t, l H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.69-7.71 (d, I H), 7.85-7.87(d, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);
(62)2-(2- thienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide ' HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d, l H), 6.56-6.5 8(t, l H), 6.75-6.76(d, I H), 7.02-7.04(t,I H), 7.17-7.1 9(t, l H), 7.43-7.45(t, l H), 7.69-7.71 (d, l H), 7.85-7.87(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(63)2-(2- thienyl)-1H-benzimidazole-4-(N-5- benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1 H), 6.93(s, I H), 7.17-7.1 9(t, l H), 7.43-7.45(1,1 H), 7.54-7.56(d, l H), 7.69-7.71 (d, I H), 7.85-7.87(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H) ;
(64)2-(2- thienyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.17-7.1 9(t, l H), 7.43-7.45(t, l H), 7.69-7.71(d,1 H), 7.85-7.87(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d,i H), 8.37(s,2H), 9.24-9.26(d,1 H), 13.00-13.03(d,I H);
(65)2-(2- thienyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.17-7.1 9(t, I H), 7.43-7.45(t, I H), 7.69-7.71 (d, I
H), 7.85-7.87(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.61 (s, I H), 8.63-8.65(d,1 H), 13.71-13.75(d,I H);
(66)2-(2- thienyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.17-7. 19(t, I H), 7.43-7.45(t,1 H), 7.69-7.71(d,1 H), 7.85-7.87(d, I H), 7.90-7.91 (d, I H), 7.93-7.94(d,IH);
(67)2-(2- thienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide i HNMR (DMSO, 400MHz) 8: 7.17-7.19(t, I H), 7.43-7.45(t, I H), 7.69-7.71(d, l H), 7.85-7.87(d,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.34-8.35(d,1 H), 8.36(s, I H), 8.40-8.42(d, l H);
(68)2-(2- thienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 8: 6.93-6.95 (t, I H), 7.17-7.19(1, I H), 7.69-7.71(d, l H), 7.85-7.87(d,IH), 7.43-7.45(t,1H), 7.89-7.91(d,IH), 7.93-7.94(d,1H), 8.45-8.46(d,2H);
(69)2-(2- thienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide ' HNMR (DMSO, 400MHz) 6: 6.62-6.64(t, I H), 6.70-6.72(d, l H), 7.17-7.1 9(t, I
H), 7.43-7.45(t. I H), 7.55-7.57(t, l H), 7.69-7.71 (d, l H), 7.85-7.87(d, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.07-8.09(d, I H);
(70)2-(2- thienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide ' HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.17-7.19(t, I H), 7.43-7.45(t, I H), 7.69-7.7 1(d, I H), 7.85-7.87(d, I H), 7.89-7.91(d, l H), 7.93-7.94(d, l H), 8.1 2(s, l H);
(71)2-(2- thienyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 7.17-7.1 9(t, I H), 7.43-7.45(t, l H), 7.69-7.71 (d, l H), 7.82(s,IH), 7.85-7.87(d,IH), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);
(72)2-(2- thienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 8: 3.82(s,6H), 5.71 (s, I H), 7.17-7.19(t,I H), 7.43-7.45(t, I H), 7.69-7.71 (d, I H), 7.85-7.87(d, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H) ;
(73)2-(2- thienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 8: 5.98(s, l H), 7.17-7.19(t,1 H), 7.43-7.45(t, l H), 7.69-7.71 (d, I H), 7.74(s,2H), 7.85-7.87(d, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);
(74)2-(2- thienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 7.17-7.1 9(t, I H), 7.43-7.45(t, l H), 7.69-7.71 (d, l H), 7.85-7.87(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.34(s, I H);
(75)2-(2- thienyl)-1H-benzimidazole-4-(N-o-tluorophenyl)amide ' HNMR (DMSO, 400MHz) 6: 6.60-6.61 (d, I H), 6.63-6.65(t, l H), 6.96-6.98(t, l H), 6.99-7.01(d,1 H), 7.17-7.1 9(t, l H), 7.43-7.45(t, l H), 7.69-7.71(d, l H), 7.85-7.87(d,1 H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H);
(76)2-(2- thienyl)-1H-benzimidazole-4-(N-2-hydroxyl4-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 5.46-5.48(d, l H), 7.10-7.11 (d, l H), 7.17-7.1 9(t, l H), 7.43-7.45(t, I H), 7.69-7.71(d, l H), 7.82(s, l H), 7.85-7.87(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d,IH);
(77)2-(2- thienyl)-1H-benzimidazole-4-(N-6-purinyl)amide ' HNMR (DMSO, 400MHz) 8: 7.17-7.1 9(t, l H), 7.43-7.45(t, l H), 7.69-7.71 (d, l H), 7.85-7.86(d,1 H), 7.87-7.88(d, l H), 7.89-7.91(d, l H), 7.93-7.94(d, l H), 8.16-8.18(d, l H);
(78)2-(2- thienyl)-IH-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 8: 7.17-7.19(t, l H), 7.43-7.45 (t, l H), 7.69-7.71(d, l H), 7.85-7.87(d,IH), 7.89-7.91(d,1H), 7.93-7.94(d,IH), 8.57-8.59(d,1H), 11.53(s,1H);
(79)(L)-2-(4-methoxypyridyl)-l H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide ' HNMR (DMSO, 400MHz) 6: 3.17-3.18(m,IH), 3.25-3.28(m, I H), 3.50-3.52(m, l H), 3.65-3.68(t, ] H), 3.70-3.72(d, I H), 3.83(s,3H), 4.73-4.77(t, I H), 7.31 (s, l H), 7.43-7.45(t, l H), 7.59-7.61 (d. I H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 8.17-8.20(d,2H), 8.49-8.51(d,I H);
(80)(L)-2-(4-methoxypyridyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminopheny Ihydroxyethyl)Jamide ' HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3.65-3.68(t, l H), 3.70-3.72(d, l H), 3.83(s,3H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.31 (s, l H), 7.43-7.45(t,1 H), 7.59-7.61 (d, l H), 7.89-7.90(d, l H), 7.93-7.95(d,1 H) , 8.49-8.51(d,1 H);
(81)2-(4-methoxypyridyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyeth yl)lamide 'HNMR (DMSO, 400MHz) 8: 1.12-1.15(d,3H), 3.25-3.28(m,IH), 3.65-3.68(t,IH), 3.83(s,3H), 4.73-4.77(t, l H), 7.29-7.30(d,2H), 7.31 (s, l H), 7.40-7.41(d,2H), 7.43-7.45(t, l H), 7.59-7.61 (d, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.49-8.51 (d, I H);
(82)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide '1-1NMR (DMSO, 400MHz) 8: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,3H), 7.31 (s, l H), 7.43-7.45(t,1 H), 7.59-7.61 (d, I H), 7.89-7.91 (d, l H), 7.93-7.94(d,1 H), 8.49-8.5 1(d, I H);
(83)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m, I H), 2.65-2.66(m, I H), 2.69-2.70(m, I H), 2.72-2.74(m, ] H), 2.77-2.80(m, l H), 3.02-3.05(m, l H), 3.83(s,3H), 3.99-4.01 (m, l H), 7.31 (s, l H), 7.43-7.45(t, l H), 7.59-7.61 (d, l H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 8.49-8.51(d, I H);
(84)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.59-7.61 (d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.49-8.51 (d,I H) ;
(85)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,3H); 6.27(s,2H), 6.38-6.40(d,IH), 6.56-6.58(t, l H), 6.75-6.76(d, I H), 7.02-7.04(t, I H), 7.31 (s, I H), 7.43-7.45(t, I H), 7.59-7.61 (d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.49-8.51 (d, I H);
(86)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,3H), 6.35-6.37(d, I H), 6.93(s, I H), 7.31(s, I
H), 7.43-7.45(t, l H), 7.54-7.56(d, l H), 7.59-7.61 (d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.49-8.51 (d, I H);
(87)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide ' HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31 (s, l H), 7.43-7.45(t, l H), 7.59-7.61 (d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.37(s,2H), 8.49-8.51 (d, I H), 9.24-9.26(d, l H), 13.00-1 3.03(d, I H);
(88)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,IH), 7.43-7.45(t,IH), 7.59-7.61 (d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.49-8.51 (d, I H), 8.61 (s, I H), 8.63-8.65(d,1H), 13.71-13.75(d,IH);
(89)2-(4-methoxypyridyl)-1H-benzim idazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 8: 1.91-I.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,3H), 7.31(s,IH), 7.43-7.45(t,IH), 7.59-7.61(d,IH), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.5 1 (d, I H);
(90)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide ' HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s, l H), 7.43-7.45(t, l H), 7.59-7.61 (d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.34-8.35(d,1 H), 8.36(s, I H), 8.40-8.42(d, I H), 8.49-8.51(d, I H);
(91)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 6.93-6.95(t,1 H), 7.31(s, I H), 7.43-7.45(t,1 H), 7.59-7.61 (d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.45-8.46(d,2H), 8.49-8.51(d, I H) ;
(92)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 6.62-6.64(t,IH), 6.70-6.72(d,IH), 7.31 (s, I H), 7.43-7.45(t,1 H), 7.55-7.57(t, I H), 7.59-7.61(d,1 H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.07-8.09(d, I H), 8.49-8.51 (d, I H);
(93)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) S: 2.45(s,3H), 3.83(s,3H), 7.31(s,IH), 7.43-7.45(t,lH), 7.59-7.61 (d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.1 2(s, I H), 8.49-8.51 (d1 H) ;
(94)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,3H), 7.31(s,IH), 7.43-7.45(t,IH), 7.59-7.61 (d, I H), 7.82(s, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.33(s, I H), 8.49-8.51(d,1H), 11.53(s,IH);
(95)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 3.85(s,3H), 5.71(s, l H), 7.31(s, l H), 7.43-7.45(t, I H), 7.59-7.61(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.49-8.51 (d, I H);
(96)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.98(s,1H), 7.31(s,IH), 7.43-7.45(t,IH), 7.74(s,2H), 7.89-7.91(d,I H), 7.93-7.94(d, I H), 8.49-8.51(d,I H);
(97)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,3H), 7.31(s, I H), 7.43-7.45(t, I H), 7.59-7.61 (d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.49-8.51 (d, I H), 9.34(s, I H);
(98)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 6.60-6.61(d,1H), 6.63-6.65(t,IH), 6.96-6.98(t, I H), 6.99-7.01 (d, I H), 7.31 (s, I H), 7.43-7.45(t, I H), 7.59-7.61(d,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.49-8.51 (d, I H);
(99)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.46-5.48(d,IH), 7.10-7.11(d,IH), 7.31 (s, l H), 7.43-7.45(t, l H), 7.59-7.6 1(d, I H), 7.82(s, l H), 7.89-7.9 1(d, l H), 7.93-7.94(d, I H), 8.49-8.51(d, I H);
(100)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61 (d, I H), 7.86-7.88(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.16-8.1 8(d, l H), 8.49-8.51(d, I H) ;
(101)2-(4-methoxypyridyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,IH), 7.43-7.45(t,IH), 7.59-7.61 (d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d,1 H), 8.49-8.5 1(d, I H), 8.57-8.59(d, l H), I1.53(s,1H);
(102)(L)-2-(6-methoxypy ridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide ' HNMR (DMSO, 400MHz) S: 3.17-3.1 8(m, I H), 3.25-3.28(m, I H), 3.50-3.52(m, l H), 3.65-3.68(t, I H), 3.70-3.72(d,1 H), 3.80(s, I H), 4.73-4.77(t, l H), 6.50-6.52(d, l H), 7.38-7.40(d, I H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.72-7.74(t, l H), 7.89-7.90(d,1 H), 7.93-7.95(d,IH), 8.17-8.20(d,2H);
(103)(L)-2-(6-methoxypyridyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophen ylhyd roxyethyl)] am ide 'HNMR (DM SO, 400MHz) 6: 3.1 7-3.18(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m,1 H), 3.65-3.68(t, l H), 3.70-3.72(d, I H), 3.80(s, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.50-6.52(d,1 H), 6.56-6.58(d,2H), 7.1 1-7.13(d,2H), 7.38-7.40(d, l H), 7.43-7.45(t, l H), 7.72-7.74(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d, I H);
(104)2-(6-methoxypyridyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyet hyl)]amide 'HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,IH), 3.80(s, I H), 4.73-4.77(t, I H), 6.50-6.52(d, I H), 7.29-7.30(d,2H), 7.38-7.39(d, l H), 7.40-7.41(d,2H), 7.43-7.45(t, I H), 7.89-7.91(d,I H), 7.72-7.74(t,1 H), 7.93-7.94(d, 1 H) ;
(105)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-N'-piperadinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.80(s, I H), 6.50-6.52(d, I H), 7.38-7.40(d, I H), 7.43-7.45(t, l H), 7.72-7.74(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(106)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2 .69-2.70(m, l H), 2.72-2.74(m, l H), 2.77-2.80(m, I H), 3.02-3.05(m, l H), 3.80(s, l H), 3.99-4.01 (m, I H), 6.50-6.52(d, I H), 7.3 8-7.40(d, I H), 7.43-7.45(t,1 H), 7.72-7.74(t, I H), 7.89-7.91(d, I H), 7.93-7.94(d, I H);
(107)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 3 .80(s, l H), 6.50-6.52(d, l H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.38-7.40(d, I H), 7.43-7.45(t, l H), 7.72-7.74(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(108)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 3.80(s, l H), 6.27(s,2H), 6.38-6.40(d, l H), 6.50-6.52(d,1 H), 6.56-6.58(t. I H), 6.75-6.76(d, I H), 7.02-7.04(t, l H), 7.3 8-7.40(d, l H), 7.43-7.45(t,I H), 7.72-7.74(t,1 H), 7.89-7.91(d, I H), 7.93-7.94(d,1 H) ;
(109)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide ' HNMR (DMSO, 400MHz) 8: 3.80(s, I H), 6.35-6.37(d, I H), 6.50-6.52(d,1 H), 6.93(s, I H), 7.38-7.40(d, I H), 7.43-7.45(t, I H), 7.54-7.56(d, I H), 7.72-7.74(t, l H), 7.89-7.91(d, I H), 7.93-7.94(d.1 H) ;
(110)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 3.80(s,IH), 6.50-6.52(d,IH), 7.38-7.40(d,IH), 7.43-7.45(t, l H), 7.72-7.74(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,IH);
(111)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-4'-pyrazolyI)amide ' HNMR (DM SO, 400M Hz) 6: 3.80(s, l H), 6.50-6.52(d, l H), 7.38-7.40(d, I H), 7.43-7.45(t, l H), 7.72-7.74(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.61 (s, I H), 8.63-8.65(d,I H), 13.71-13.75(d, I H);
(112) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.80(s,I H), 6.50-6.52(d, l H), 7.38-7.40(d, I H), 7.43-7.45(t, l H), 7.90-7.91 (d, I H), 7.72-7.74(t, I H), 7.93-7.94(d, I H);
(113) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide ' HNMR (DMSO, 400M Hz) 6: 3.80(s, l H), 6.50-6.52(d, l H), 7.38-7.40(d, l H), 7.43-7.45(t, I H), 7.72-7.74(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.34-8.35(d, I H), 8.36(s, I H), 8.40-8.42(d, I H);
(114) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.80(s, l H), 6.50-6.52(d, I H), 6.93-6.95(t, I H), 7.3 8-7.40(d, I H), 7.43-7.45(t, I H), 7.72-7.74(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.45-8.46(d,2H);
(115) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 8: 3 .80(s, I H), 6.50-6.52(d, ] H), 6.62-6.64(t, I H), 6.70-6.72(d, I H), 7.38-7.40(d, I H), 7.43-7.45(t,1 H), 7.55-7.57(t, I H), 7.72-7.74(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.07-8.09(d, I H) ;
(116) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 3.80(s,IH), 6.50-6.52(d,IH), 7.3 8-7.40(d, I H). 7.43-7.45(t, I H), 7.72-7.74(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.12(s, I H);
(117) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.80(s, I H), 6.50-6.52(d,1 H), 7.38-7.40(d, I H), 7.43-7.45(t,1H), 7.72-7.74(t,IH), 7.82(s,IH), 7.89-7.91(d,IH), 7.93-7.94(d,IH), 8.33(s,1H), 11.53(s,IH);
(118) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 3.80(s,1 H), 3.82(s,6H), 5.71(s, I H), 6.50-6.52(d, I
H), 7.38-7.40(d,I H), 7.43-7.45(t, ] H), 7.72-7.74(t,1 H), 7.89-7.91(d, l H), 7.93-7.94(d, l H) ;
(119)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.80(s, l H), 5.98(s, l H), 6.50-6.52(d, I H), 7.38-7.40(d,I H), 7.43-7.45(t,I H), 7.74(s,2H), 7.89-7.91(d,1 H), 7.72-7.74(t, I H), 7.93-7.94(d,] H);
(120)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO. 400MHz) 6: 3.80(s, l H), 6.50-6.52(d, I H), 7.38-7.40(d, I H), 7.43-7.45(t, I H). 7.72-7.74(t,1 H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 9.34(s,1 H);
(121)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 3. 80(s, I H), 6.50-6.52(d, I H), 6.60-6.61 (d, I H), 6.63-6.65(t, I H), 6.96-6.98(t, l H), 6.99-7.01 (d, I H), 7.38-7.40(d, l H), 7.43-7.45(t, l H), 7.72-7.74(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(122)2-(6-methoxypyridyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 8: 3 .80(s, I H), 5.46-5.48(d, I H), 6.50-6.52(d,1 H), 7.10-7.11 (d, I H), 7.38-7.40(d, l H), 7.43-7.45(t, I H), 7.72-7.74(t, I H), 7.82(s, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(123)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 8: 3.80(s, ] H), 6.50-6.52(d, I H), 7.38-7.40(d,1 H), 7.43-7.45(t, l H), 7.72-7.74(t, I H), 7.86-7. 88(d, l H), 7.89-7.91 (d, ] H), 7.93-7.94(d, I H), 8.16-8.18(d,I H);
(124)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.80(s,IH), 6.50-6.52(d,IH), 7.38-7.40(d,lH), 7.43-7.45(t,1 H), 7.72-7.74(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.57-8.59(d, l H), 11.53(s,IH);
(125)(L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henyl hyd roxyet hyl)l a m i de 'HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m, l H), 3.65-3.68(t, I H), 3.70-3.72(d, l H), 4.73-4.77(t,1 H), 6.65-6.67(d,1 H), 6.86(s, I H), 7.43-7.45(t, I H), 7.62-7.65(d,2H), 7.89-7.90(d,1 H), 7.93-7.95(d, I H), 8.17-8.20(d,2H), 8.32-8.35(d,1 H);
(126)(L)-2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 3.17-3.18(m,IH), 3.25-3.28(m,IH), 3.50-3.52(m, l H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 6.65-6.67(d, I H), 6.86(s,1 H), 7.11-7.13(d,2H), 7.43-7.45(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 8.32-8.35(d, I H);
(127)2-(4-dimethylaminopyridyl)-lH-benzimidazole-4-(N-(1-methyl-2-p-chlorophenylhydro xyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 2.68(s,6H), 3.25-3.28(m,1H), 3.65-3.68(t, l H), 4.73-4.77(t,1 H), 6.65-6.67(d, l H), 6.86(s, I H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1 H), 7.89-7.91(d,I H), 7.93-7.94(d,1 H), 8.32-8.35(d, I H);
(128)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.68(s,6H), 3.10-3.15(t,4H), 6.65-6.67(d, I H), 6.86(s, l H), 7.43-7.45(t,1 H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H), 8.32-8.35(d, I H);
(129)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,1H), 2.68(s,6H), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.77-2.80(m,1 H), 3.02-3 .05(m, l H), 3.99-4.01 (m, I H), 6.65-6.67(d, I H), 6.86(s, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.32-8.35(d,I H);
(130)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,IH), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.32-8.35(d,1H);
(131)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 8: 2.68(s,6H), 6.27(s,2H), 6.38-6.40(d,IH), 6.56-6.58(t, I H), 6.65-6.67(d,1 H), 6.75-6.76(d,1 H), 6.86(s, I H), 7.02-7.04(t, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.32-8.35(d, l H);
(132)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) S: 2.68(s,6H), 6.35-6.37(d,1H), 6.65-6.67(d,IH), 6.86(s, I H), 6.93(s, l H), 7.43-7.45(t,1 H), 7.54-7.56(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.32-8.35(d,1 H) ;
(133)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)a mide 'HNMR (DMSO, 400MHz) 8: 2.68(s,6H), 6.65-6.67(d,IH), 6.86(s,IH), 7.43-7.45(t, I H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H), 8.32-8.35(d, I H), 8.37(s,2H), 9.24-9.26(d, I H), 13.00-13.03(d, l H);
(134)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide ' HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d, I H), 6.86(s,1 H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.32-8.35(d, l H), 8.61 (s,1 H), 8.63-8.65(d,IH), 13.71-13.75(d,IH);
(135)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.68(s,6H), 2.80-2.83(m,4H), 6.65-6.67(d, I H), 6.86(s, I H), 7.43-7.45(t, I H), 7.90-7.91 (d, I H), 7.93-7.94(d, I H) ;
(136)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,IH), 6.86(s,IH), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.32-8.35(d, I H), 8.34-8.35(d, I H), 8.36(s, I H), 8.40-8.42(d, I H);
(137)2-(4-dimethylaminopyridyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d, I H), 6.86(s, I H), 6.93-6.95(t, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.32-8.35(d, l H), 8.45-8.46(d,2H);
(138)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.62-6.64(t, l H), 6.65-6.67(d, I H), 6.70-6.72(d, I H), 6.86(s, I H), 7.43-7.45(t, I H), 7.55-7.57(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d,IH), 8.07-8.09(d,IH), 8.32-8.35(d,IH);
(139)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 2.68(s,6H), 6.65-6.67(d,IH), 6.86(s,IH), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.1 2(s, l H), 8.32-8.35(d, l H);
(140)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,IH), 6.86(s,IH), 7.43-7.45(t, I H), 7.82(s, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.30(s, l H), 8.32-8.35(d,1 H), 11.53(s,IH);
(141)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 2.68(s,6H), 3.82(s,6H), 5.71(s, I H), 6.65-6.67(d, I
H), 6.86(s, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.32-8.35(d, I H);
(142)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 5.98(s, l H), 6.65-6.67(d,1 H), 6.86(s, I
H), 7.43-7.45(t,1 H), 7.74(s,2H), 7.89-7.91 (d, l H), 7.93-7.94(d,1 H), 8.32-8.35(d,1 H);
(143)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4 (N-4,6-dichloro-5-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d, I H), 6.86(s, l H), 7.43-7.45(t, I H), 7.89-7.91(d, l H), 7.93-7.94(d, I H), 8.32-8.35(d, l H), 9.34(s,1 H);
(144)2-(4-dimethylaminopyridyl)-1H-benzimidazole=4 (N-o-fluorophenyl)amide ' HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.60-6.61 (d, l H), 6.63-6.64(t, l H), 6.66-6.67(d,1 H), 6.86(s, l H), 6.96-6.98(t,1 H), 6.99-7.01(d, l H), 7.43-7.45 (t, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.32-8.35(d, I H);
(145)2-(4-dimethylaminopyridyl)4H-benzimidazole-4(N-2-hydroxyl4-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 2.68(s,6H), 5.46-5.48(d,IH), 6.65-6.67(d,1H), 6.86(s, I H), 7.10-7.11 (d, I H), 7.43-7.45(t, I H), 7.82(s, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.32-8.35(d, l H);
(146)2{4dimethylaminopyridyl)-1 H-benzimidazole-4(N 4.pu rinyl)amide ' HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1 H), 6.86(s, I H), 7.43-7.45(t, l H), 7.86-7.88(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.16-8.1 8(d, l H), 8.32-8.35(d, l H);
(147)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide ' HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d, l H), 6.86(s, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.32-8.35(d, l H), 8.57-8.59(d, l H), 11.53(s,IH);
(148)(I,}2-(2,3,4-trimethoxypheny¾1H-benzimidazole-4-(N-(l-hydroxymethyl-2-p-nitrophenylh ydroxyethyl)]amide ' 14NMR (DMSO, 400MHz) S: 3.17-3.1 8(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m, I H), 3.65-3.68(t, I H), 3.70-3.72(d,1 H), 3.83(s,9H), 4.73-4.77(t, I H), 6.50-6.52(d, l H), 7.13-7.1 4(d, l H), 7.43-7.45(t,1 H), 7.62-7.65(d,2H), 7.89-7.90(d, I H), 7.93-7.95(d, l H), 8.17-8.20(d,2H);
(149)(L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(l-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide ' HNMR (DMSO, 400MHz) S: 3.17-3.1 8(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m, I
H), 3.65-3 .68(t, I H), 3.70-3.72(d,1 H), 3.83(s,9H), 4.73-4.77(t, l H), 6.27(s,2H), 6.50-6.52(d, I H), 6.56-6.58(d,2H), 7.11-7.1 2(d,2H), 7.13-7.1 4(d, l H), 7.43-7.45(t, I H), 7.89-7.90(d, l H), 7.93-7.95(d, I H):
(150)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethy 1)]amide 'HNMR (DMSO, 400MHz) S: 1.12-1.15(d,3H), 3.25-3.28(m, l H), 3.65-3.68(t, l H), 3.83(s,9H), 4.73-4.77(t, I H), 6.50-6.52(d, I H), 7.13-7.14(d, I H), 7.29-7.30(d,2H), 7.40-7.4 1 (d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d. I H), 7.93-7.94(d, I H);
(151)2-(2,3,4-trimethoxyphenyl)-lH-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) S: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,9H), 6.50-6.52(d, I H), 7.13-7.14(d,I H), 7.43-7.45(t, ] H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(152)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) S: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m,1 H), 2.72-2.74(m, l H), 2.77-2.80(m, l H), 3 .02-3.05(m, I H), 3.83(s,9H), 3.99-4.01 (m, l H), 6.50-6.52(d,1 H), 7.13-7. 14(d, I H), 7.43-7.45(t, l H), 7.89-7.91(d, l H), 7.93-7.94(d,1 H);
(153)2-(2,3,4-trimethoxyphenyl)-lH-ben imidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,9H), 6.50-6.52(d, I H), 7.10-7.11(d, I H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H);
(154)2-2,3,4-trimethoxyphenyl}1H-benzimidazole 4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.27(s,2H), 6.38-6.40(d,IH), 6.50-6.52(d, l H), 6.56-6.58(t, l H), 6.75-6.76(d, l H), 7.02-7.04(t, I H), 7.13-7.1 4(d, I H), 7.43-7.45(t, I H), 7.89-7.91(d,I H), 7.93-7.94(d, 1 H) ;
(155)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.35-6.37(d, l H), 6.50-6.52(d, l H), 6.93(s, l H), 7.13-7.14(d, I H), 7.43-7.45(t, I H), 7.54-7.56(d, I H), 7.89-7.91(d,1 H), 7.93-7.94(d,1 H);
(156)2- 2,3,4-trimethoxyphenyl}1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolynamide 'HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d,IH), 7.13-7.14(d,1H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.37(s,2H), 9.24-9.26(d, I H), 13.00-13.03(d, I H);
(157)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d,IH), 7.13-7.14(d,1H), 7.43-7.45(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.61(s, l H), 8.63-8.65(d, l H), 13.71-13.75(d,I H);
(158)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,9H), 6.50-6.52(d, I H), 7.13-7.14(d,1 H), 7.43-7.45(t,1 H), 7.90-7.91(d, l H), 7.93-7.94(d, I H);
(159)2-(2,3,4-trimethoxyphenyl}1H-benzimidazole 4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,9H), 6.50-6.52(d, l H), 7.13-7.14(d,1 H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.34-8.35(d, l H), 8.36(s, l H), 8.40-8.42(d, I H);
(160)2-(2,3,4-trimethoxyphenyl}1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,9H), 6.50-6.52(d,IH), 6.93-6.95(t,IH), 7.13-7.14(d, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.45-8.46(d,2H);
(161)2-(2,3,4-trimethoxyphenyl}1H-benzimidazole-4-(N-2-pyridyl)amide ' HNMR (DMSO, 400MHz) 8: 3.83(s,9H), 6.50-6.52(d, l H), 6.62-6.64(t,1 H), 6.70-6.72(d, I H), 7.13-7. 14(d, l H), 7.43-7.45(t, l H), 7.55-7.57(t, l H), 7.89-7.91(d, I H), 7.93 -7.94(d, l H), 8.07-8.09(d,1 H);
(162)2-(2,3,4-trimethoxyphenyl)-IH-benzimidazole- -(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1 H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d,I H), 8.12(s,1 H);
(163)2-(2,3,4-trimethoxyphenyl)1H-benzimidazole-4-(N-2,4 dihydroxyl-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,9H), 6.50-6.52(d,IH), 7.13-7.14(d,IH), 7.43-7.45(t,1H), 7.82(s,IH), 7.89-7.91(d,IH), 7.93-7.94(d,IH), 8.33(s,1H), 11.53(s,1H);
(164)2-(2,3,4-trimethoxyphenyl}IH-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 3.83(s,9H), 5.71(s,1H), 3.83(s,9H), 6.50-6.52(d, I H), 7.13-7.14(d,1 H), 7.43-7.45(t,1 H), 7.89-7.91(d, I H), 7.93-7.94(d,1 H);
(165)2{2,3,4-trimethoxypheny¾1H-benzimidazole-4 (N-4-chloro-6-amino-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,9H), 5.98(s, I H), 6.50-6.52(d, I H), 7.13-7.14(d, I H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(166)2-(2,3,4-trimethoxypheny¾1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,9H), 6.50-6.52(d, l H), 7.13-7.1 4(d, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.34(s, I H);
(167)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d, I H), 6.60-6.61(d, l H), 6.63-6.65(t, I H), 6.96-6.98(t, I H), 6.99-7.01 (d, I H), 7.13-7. 14(d, I H), 7.43-7.45(t,1 H), 7.89-7.91(d,IH), 7.93-7.94(d,IH);
(168)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,9H), 5.46-5.48(d,I H), 6.50-6.52(d, l H), 7.10-7.11(d, I H), 7.13-7.14(d. I H), 7.43-7.45(t, I H), 7.82(s, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H);
(169)2-(2,3,4-trimethoxyphenylylH-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d,IH), 7.13-7.14(d,IH), 7.43-7.45(t, l H), 7.86-7.88(d, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.16-8.1 8(d, I H);
(170)2-(2,3,4-trimethoxyphenyl}1H-benzimidazole-4-(N-(-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) S: 3.83(s,9H), 6.50-6.52(d, l H), 7.13-7.1 4(d, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.57-8.59(d, ] H), 11 .53(s, l H);
(171)(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole4-[N- (1-hydroxymethyl-2-p-nitroph enylhydroxyethyl)Jamide ' HNMR (DMSO, 400MHz) S: 3.17-3.1 8(m, ] H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3.65-3.68(t, l H), 3.70-3.72(d, I H), 3.83(s,3H), 4.73-4.77(t, I H), 5.35(s, l H), 6.88-6.90(d, l H), 7.21 (s, I H), 7.43-7.45(t, I H), 7.53-7.55(d, I H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d,IH), 8.17-8.20(d,2H);
(172)(L)-2-(3-hydroxyl-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminop henylhydroxyethyl)Jamide ' HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, I H), 3.25-3.28(m,1 H), 3.50-3.52(m,1 H), 3 .65-3.68(t, I H), 3.70-3.72(d,1 H), 3.83(s,3H), 4.73-4.77(t, I H), 5 .35(s, I H), 6.27(s,2H), 6.56-6.58(d,2H), 6.88-6.90(d, I H), 7.11-7.1 3(d,2H), 7.21 (s, l n), 7.43-7.45(t, ] H), 7.53-7.55(d,IH), 7.89-7.90(d,1H), 7.93-7.95(d,IH);
(173)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N{1-methyl-2-p-chlorophenylhydro xyethyl)Jamide 'I-INMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 3.25-3.28(m,]H), 3.65-3.68(t,IH), 3.83(s,3H), 4.73-4.77(t,1 H), 5.35(s,1 H), 6.88-6.90(d,1 H), 7.21 (s, l H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,IH), 7.53-7.55(d,1H), 7.89-7.91(d,IH), 7.93-7.94(d,1H);
(174)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.83(s,3H), 5.35(s, I H), 6.88-6.90(d, l H), 7.21 (s, I H), 7.43-7.45(t, I H), 7.53-7.55(d, l H), 7.89-7.91(d, l H), 7.93-7.94(d, l H) ;
(175)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,1H), 2.69-2.70(m, I H), 2.72-2 .74(m, I H), 2.77-2.80(m, I H), 3.02-3 .05 (m,1 H), 3.83(s,3H), 3.99-4.01 (m, l H), 5.35(s, I H), 6.88-6.90(d,1 H), 7.21 (s, I H), 7.43-7.45(t, I H), 7.53-7.55(d,IH), 7.89-7.91(d,1H), 7.93-7.94(d,1H);
(176)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide ' HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s, I H), 6.88-6.90(d,1 H), 7.12-7.15(d,2H), 7.21 (s, l H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.53-7.55(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(177)2{3-hydroxyl-4-methoxyphenyl}1H-benzimidazok-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,IH), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.5 8(t, I H), 6.75-6.76(d, I H), 6.88-6.90(d, I H), 7.02-7.04(t,1 H), 7.21 (s, I H), 7.53-7.55(d,IH), 7.43-7.45(t,IH), 7.89-7.91(d,IH), 7.93-7.94(d,IH);
(178)2{3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,IH), 6.35-6.37(d,IH), 6.88-6.90(d, l H), 6.93(s,1 H), 7.21 (s, l H), 7.43-7.45(t, I H), 7.49-7.52(d, I H), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H) ;
(179)2 (3-hydroxyl-methoxypheny¾1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,IH), 6.88-6.90(d,1H), 7.21(s,IH), 7.43-7.45(t, I H), 7.53-7.55(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.37(s,2H), 9.24-9.26(d, I H), 13.00-13 .03(d, I H) ;
(180)2-(3=-hydroxyl-methoxypheny¾1H benzinidazole-4-(N-4'-pymzolyl)amide ' HNMR (DMSO, 400MHz) S: 3.83(s,3H), 5.35(s, I H), 6.88-6.90(d, l H), 7.21(s, l H), 7.43-7.45(t, I H), 7.53-7.55(d,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d,I H), 8.61(s, l H), 8.63-8.65(d,IH), 13.71-13.75(d,IH);
(181)2{3-hydroxyl-4-methoxyphenyl}1H-benamidazole- 4-(N-(N'-piperazinyL))amide 'HNMR (DMSO, 400MHz) S: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,3H), 5.35(s,IH), 6.88-6.90(d,IH), 7.21(s,1H), 7.43-7.45(t,IH), 7.53-7.55(d,IH), 7.90-7.91(d, I H), 7.93-7.94(d,I H);
(182)2{3-hydros:yl -methoxypheny¾1H-be midazole-4-(N 2-pyi nyl)amide ' HNMR (DMSO, 400MHz) S: 3.83(s,3H), 5.35(s, l H), 6.88-6.90(d, l H), 7.21(s, I H), 7.43-7.45(t, ]H), 7.53-7.55(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.34-8.35(d, l H), 8.36(s, I H), 8.40-8.42(d, l H);
(183)2-(3-hydroxyl-4-methoxyphenyl}1H-benamidazole-4-(N 2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,3H), 5.35(s,IH), 6.88-6.90(d,1H), 6.93-6.95(t, I H), 7.21 (s, I H), 7.43-7.45(t, l H), 7.53-7.55(d,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.45-8.46(d,2H);
(184)2-(3-hydroxyl-4-methoxyphenyl}1H-benzimidazole-4-(N 2-pyndyl)amide 'HNMR (DMSO, 400MHz) S: 3.83(s,3H), 5.35(s,IH), 6.62-6.64(t,IH), 6.70-6.72(d, I H), 6.88-6.90(d, I H), 7.21 (s, l H), 7.43-7.45(t, l H), 7.51-7.52(d, I H), 7.55-7.57(t, I H), 7.89-7.9 1(d, l H), 7.93-7.94(d, I H), 8.07-8.09(d,1 H);
(185)2-(3-hydroxyl-4-methoxypheny1) H-benzimidazole-4{N--methyl-5`thiaz(lyl)amide 'HNMR (DMSO, 400MHz) S: 2.45(s,3H), 3.83(s,3H), 5.35(s,IH), 6.88-6.90(d,IH), 7.21(s,1 H), 7.43-7.45(t,1 H), 7.53-7.55(d,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.12(s, I H);
(186)2-(3-hydroxyl- -methoxyphenyl -1H-benamidazole-4-{N 2,4-dihydroxyI-5-pyi imidinyl)amide ' HNMR (DMSO, 400MHz) S: 3.83(s,3H), 5.35(s, l H), 6.88-6.90(d, I H), 7.21(s, l H), 7.43-7.45(t, l H), 7.53-7.55(d, l H), 7.82(s, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.33(s, I H), 11.53(s,IH);
(187)2-(3'-hydroxyl-methoxyphenyl}1H-benzimidazole4 -(N-4,6-dimethoxy 2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) S: 3.79(s,6H), 3.83(s,3H), 5.35(s, I H), 5.71(s, I H), 6.88-6.90(d, I H), 7.21 (s, I H), 7.43-7.45(t, l H), 7.53-7.55(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(188)2 (3-hydroxyl-l-methoxyphenyl}1H-beutimida7ole~4-(N~-chlom.6-amino-2-pyrimid nyl)amide 'HNMR (DMSO, 400MHz) 5: 3.83(s,3H), 5.35(s,IH), 5.98(s,1H), 6.88-6.90(d,IH), 7.21 (s, l H), 7.43-7.45(t, I H), 7.53-7.55(d, I H), 7.74(s,2H), 7.89-7.91 (d,1 H), 7.93-7.94(d, l H);

(189 {3-hydroxyl-4-met oxyphenyl}1H-benumidbwle-4(N4,6-dicbIo 5yryrimidinyl)amide 'HNMR (DMSO, 400MHz) 5: 3.83(s,3H), 5.35(s, I H), 6.88-6.90(d, I H), 7.21(s,1 H), 7.43-7.45(t, l H), 7.53-7.55(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.34(s, l H);

(190)2 (3-hydroxyl.4-meNwxyphenyl}1H-bmuamidazo1 -4-(N-o-Buorophenyl)amide ' HNMR (DMSO, 400MHz) 5: 3.83(s,3H), 5.35(s, l H), 6.60-6.61(d, I H), 6.63-6.65(t, l H), 6.88-6.90(d, I H), 6.96-6.98(t,1 H), 6.99-7.01 (d,1 H), 7.21 (s, l H), 7.43-7.45(t, I H), 7.53-7.55(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H) ;

(191)2 (3-hydroxyl-4-methoxypheny¾1H benzimidazole 4- N-2=hydro 'HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,IH), 5.46-5.48(d,IH), 6.88-6.90(d,1 H), 7.10-7.11 (d, I H), 7.21 (s, I H), 7.43-7.45(t,1 H), 7.53-7.55(d, I H), 7.82(s,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(192)2-(3-hydroxyl-4-methoxyphenyl}1H-benamidazole 4-(N~rpurinyl)amide 'HNMR (DMSO, 400M1-1z) 8: 3.83(s,3H), 5.35(s,IH), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t, l H), 7.53-7.55(d, l H), 7.86-7.88(d, l H), 7.89-7.91(d, I H), 7.93-7.94(d, l H), 8.16-8.18(d, I H);

(193)2 (3-hydroxyl-4-methoxypheny¾1H benzimidazole-4-(N 6-hydroxyl-2-purinyl) imide 'HNMR (DMSO, 400MHz) 8: 3.83(s,3H), 5.35(s, l H), 6.88-6.90(d, l H). 7.21 (s, I H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,IH), 7.93-7.94(d,IH), 8.57-8.59(d,IH), 11.53(s,IH);

(194)(I.}2{2-Wndyl}1H-hemmnidaDO6*[N-(l-hydmVmethyl-2-p-nibrop Mibydroxyethy>))amide (refer to Figure 4) 1 HMNR(DMSO,400MHz)6:3.57-3.61(m, I H),3.66-3.70(m, I H),4.20-4.22(m, I H), 5.08-5.11 (q, l H),5.28-5.29(d, I H),6.29-6.30(d, I H), 7.28-7.32(t, I H), 7.57-7.61 (m, I H), 7.67-7.73(m,4H), 8.02-8.06(m,3H), 8.57-8.59(m, l H), 8.78-8.80(m, I H), 10.47-1 0.49(d, I H), 13.62(s, I H);

(195)(L}~2-lryridyl}1H-b dazole-4-[N{1-hydroxymethyt-2-p-aminophenylhydmxye1I
Jamide 'HNMR (DMSO, 400MHz) 8: 3.17-3.1 8(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m, l H), 3.65-3.68(t, I H), 3.70-3.72(d,I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.36-7.38(t, I H), 7.43-7.45(t, l H), 7.85-7.86(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d,IH), 8.38-8.41(d,IH), 8.59-8.60(d,1H);
(196P,Q,pyridyl}1H-be~z k 4-Ml4n&yl-2-p-chlorophmyffWdroxY&"lamide 'HNMR (DMSO, 400MHz) 8: 1.12-1.15(d,3H), 3.25-3.28(m,IH), 3.65-3.68(t,1H), 4.73-4.77(t, I H), 7.29-7.30(d,2H), 7.36-7.38(t, l H), 7.40-7.41(d,2H), 7.43-7.45(t, I H), 7.85-7.86(t, I H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 8.38-8.41 (d, l H), 8.59-8.60(d, I H) ;
(19?IZ (2-pyridy¾1H benzonidazole4-(N-N'- Wrk iny4amide 'HNMR (DMSO, 400MHz) 8: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.36-7.38(t, I H), 7.43-7.45(t, l H), 7.85-7.86(t, l H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 8.38-8.41(d,1 H), 8.59-8.60(d,1 H);

(1 p,oTy 2-piPer rY -'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.77-2.80(m, l H), 3.02-3.05(m,I H), 3.99-4.01 (m, l H), 7.36-7.38(t, I H), 7.43-7.45(t, I H), 7.85-7.86(t,1 H), 7.89-7.91(d, I H), 7.93-7.94(d, I H) 8.3 8-8.41(d, l H), 8.59-8.60(d, I H) ;

(199)2-(2-pyridyl}1H bentnidazole-4 {N-2'-benamidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.12-7.15(d.2H), 7.22-7.24(t,2H), 7.36-7.38(t,1 H), 7.43-7.45(t, I H), 7. 85-7.86(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.3 8-8.41(d, l H), 8.59-8.60(d, I H);

(200)2-(2-rfr clyl}1H-be midazole-4-(N-0-aminophenyL)amide 'HNMR (DMSO, 400MHz) 8: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,IH), 6.75-6.76(d, l H), 7.02-7.04(t, l H), 7.36-7.38(t, ] H), 7.43-7.45(t, I H), 7.85-7.86(t, l H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 8.38-8.41 (d, I H), 8.59-8.60(d,1 H) ;

(201)2 (2-p iidy¾1H-baithnidazole.4-(1 -5-bewimidaz 4onyl)ainide 'HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s,IH), 7.36-7.38(t,IH), 7.43-7.45(t, l H), 7.54-7.56(d, l H), 7.85-7.86(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.38-8.41(d,1H), 8.59-8.60(d,IH);

(202)2-(2 j idyl}1H-benzonidazole 4-(N-4'- mrbonamdio-5'-imida?.olyl)amide 'HNMR (DMSO, 400MHz) 8: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.37(s,2H), 8.38-8.41 (d, l H), 8.59-8.60(d, I H), 9.24-9.26(d, I H), 13.00-13.03(d, I H);

(ZWAV- fr kWlH4mvfinidazok-4-(N4'-pyrazolylprr-ide 'HNMR (DMSO, 400MHz) 6: 7.36-7.38(t,IH), 7.43-7.45(t,IH), 7.85-7.86(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.38-8.41 (d, l H), 8.59-8.60(d, I H), 8.61(s, l H), 8.63-8.65(d,1H), 13.71-13.75(d,IH);

(204)2-(2iry idyl}1H-bmAmW tole 4 (N-(N'-piperaanyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.36-7.38(t, I H), 7.43-7.45(t, I H), 7.85-7.86(t, l H), 7.90-7.91 (d, l H), 7.93-7.94(d, l H), 8.38-8.41(d,1 H), 8.59-8.60(d, I H);

(205)2 {2IWridyl}1H-ben imidazole-4-(N 2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.36-7.38(t,IH), 7.43-7.45(t,IH), 7.85-7.86(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.34-8.3 5(d, I H), 8.36(s, I H), 8.38-8.41 (d, ] H), 8.43-8.45(d,1H), 8.59-8.60(d,IH);

(20(-IZ (~PYridyl~ ZIl~'nmidiq'1)amide 'HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,IH), 7.36-7.38(t,IH), 7.43-7.45(t,IH), 7.85-7.86(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.38-8.41(d,1 H), 8.45-8.46(d,2H), 8.59-8.60(d, ] H);

(207)2-(2Tyiidyl}1H-benz midazole-4 (N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 6: 6.62-6.64(t, l H), 6.70-6.72(d, I H), 7.36-7.3 8(t, I
H), 7.43-7.45(t, I H), 7.55-7.57(t, l H), 7.85-7.86(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.07-8.09(d, l H), 8.38-8.41(d, I H), 8.59-8.60(d, I H);

(208)2 (2-pytidyf}1H-ben imidazole4-(N-4-methyl-5-thiazoly1)amide 'HNMR (DMSO, 400MHz) S: 2.45(s,3H), 7.36-7.38(t,1H), 7.43-7.45(t,IH), 7.85-7.86(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.1 2(s, I H), 8.38-8.41 (d, l H), 8.59-8.60(d, I H);

(209)2 (2-pyridyl} 2,4 dihydmxyl-5-~uryi)amide 'HNMR (DMSO, 400MHz) 6: 7.36-7.38(t, I H), 7.43-7.45(t, l H), 7.82(s, I H), 7.85-7.86(t, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, l H), 8.33(s, l H), 8.38-8.41 (d, l H), 8.59-8.60(d, l H), 11 .53(s,1 H) ;

(2109(Z-py idyl}1H-benzunidazole.4(N44dimethoxy 2-pyi midinyl)amide ' HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s, l H), 7.36-7.3 8(t, l H), 7.43-7.45(t, I H), 7.85-7.86(t,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.38-8.41 (d, ] H), 8.59-8.60(d, I H);

(211)2 (2-lryiidyl}1H-ber~nidazoIe 4{N~-chIom 6-am no-2-pyrimidinyl)raamide ' HNMR (DMSO, 400MHz) 6: 5.98(s, l H), 7.36-7.38(t, l H), 7.43-7.45(t, l H), 7.74(s,2H), 7.85-7.86(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.3 8-8.41(d, I H), 8.59-8.60(d, I H);

(212g{2-rfridyl}1H hbro-5- ff ii~un'de 'HNMR (DMSO, 400MHz) 8: 7.36-7.38(t,1H), 7.43-7.45(t,IH), 7.85-7.86(t,IH), 7.89-7.91(d.l H), 7.93-7.94(d, I H), 8.38-8.41 (d, I H), 8.59-8.60(d,1 H), 9.34(s, I H) ;

(213V,P, yridyl)-1H-benzonidazole-4-(N-fluor phenyl)amide 'HNMR (DMSO, 400MHz) 8: 6.60-6.61(d, l H), 6.63-6.65(t, l H), 6.96-6.98(t, l H), 6.99-7.01 (d, ] H), 7.36-7.3 8(t, I H), 7.43-7.45(t, I H), 7.85-7.86(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.38-8.41(d,1 H), 8.59-8.60(d, l H);

(214)2{2-pyrid)¾1H-berthmidazole-44N 2-hydro 'HNMR (DMSO, 400MHz) 8: 5.46-5.48(d, I H), 7.10-7.11 (d,1 H), 7.36-7.3 8(t, I
H), 7.43-7.45(t,1 H), 7.82(s, I H), 7.85-7.86(t, I H), 7.89-7.91(d,1 H), 7.93-7.94(d,1 H) 8.38-8.41(d, I H), 8.59-8.60(d, I H);

(215)2-(2-pyridyl)-1H-benzonidazo&-4-(N4purinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.36-7.38(t,1H), 7.43-7.45(t,IH), 7.85-7.86(t,1H), 7.87-7.88(d, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, l H), 8.16-8.1 8(d, l H), 8.38-8.41 (d, I H), 8.59-8.60(d,I H);

(216APTyridyi}lH droxyI-2-puri **nide 'HNMR (DMSO, 400MHz) 6: 7.36-7.3 8(t, I H), 7.43-7.45(t, I H), 7.85-7.86(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.3 8-8.41(d, l H), 8.57-8.59(d, I H), 8.59-8.60(d, l H), 11.53(s, I H);

(217)(Lylo-pyridy¾1H-benzirrtidazole 4 MI-hydrorimedWI-2-p-nWx#wMihydmxyethyn]amide 'HNMR (DMSO, 400MHz) 8: 3.17-3.1 8(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m, I
H), 3.65-3.68(t, l H), 3.70-3 .72(d, I H), 4.73-4.77(t, l H), 7.43-7.45(t,1 H), 7.57-7.60(t, I H), 7.62-7.65(d,2H), 7.89-7.90(d, I H), 7.93-7.95(d, l H), 8.17-8.20(d,2H), 8.42-8.44(d, I H), 8.70-8.72(d, I H), 9.24(s, l H);

(218)(L}2(3-lryri WIH bm&n mie-4-Ml-hydroxyrrretlrA2-lraminopherrylhydroxyethyi)]amide ' HNMR (DMSO, 400MHz) 8: 3.17-3.18(m, I H), 3.25-3.28(m,1 H), 3.50-3.52(m, l H), 3.65-3.68(t,I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.1 3(d,2H), 7.43-7.45(t, I H), 7.57-7.60(t, I H), 7.89-7.90(d, l H), 7.93-7.95(d, l H), 8.42-8.44(d, I H), 8.70-8.72(d,1 H), 9.24(s, I H);

(219)2-(3-lryridyl}1H-berramidazole 4 N 2-pipeniiinyl)amide ' HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m, I H), 2.65-2.66(m, I
H), 2.69-2.70(m, l H), 2.72-2.74(m, ] H), 2.77-2.80(m,1 H), 3.02-3.05(m, I H), 3.99-4.01 (m, l H), 7.43-7.45(t, l H), 7.5 7-7.60(t, l H), 7.89-7.91 (d, ] H), 7.93-7.94(d, I H), 8.42-8.44(d, l H), 8.70-8.72(d,1 H), 9.24(s, I H);

(220)2-(3-pyridyl}1H-benzonidaiole-4(N2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 8: 6.93-6.95(t, I H), 7.43-7.45(t, l H), 7.57-7.60(t, I
H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.41 -8.43(d, l H), 8.45-8.46(d,2H), 8.70-8.72(d,1 H), 9.24(s, I H);

(221)(1+1 4lryridyl}tH-benamidazole 4 N{14iydmxymetbyl-211 ihMbmyffodmxyeffiAlamide 'HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, l H), 3.25-3.28(m,1 H), 3.50-3.52(m, l H), 3.65-3 .68(t, l H), 3.70-3.72(d, I H), 4.73-4.77(t,1 H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 8.17-8.20(d,2H);

(222)(E}2{4pyridyl}1H-b~awie 4-M1-hydmxym&yl-2-p-aminophenylhydmxy]amide 'HNMR (DMSO, 400MHz) 6: 3.17-3.18(m,IH), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t, I H), 3.70-3.72(d,1 H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, l H), 7.89-7.90(d,1 H), 7.93-7.95(d, l H), 8.25-8.28(d,2H), 8.75-8.77(d,2H);

(223)2-(41ryridyl}II3-benhnidazole-4-(N-2-piperaanyl unide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,1H), 2.69-2.70(m, l H), 2.72-2.74(m, l H), 2.77-2.80(m, l H), 3.02-3.05(m, I H), 3.99-4.01 (m, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.25-8.28(d,2H), 8.75-8.77(d,2H);
(224)2-(4-pyridyl}1H4en imidazole-4{N-2-pyiimidinytramide ' HNMR (DMSO, 400MHz) 6: 6.93-6.95(t, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.25-8.28(d,2H), 8.45-8.46(d,2H), 8.75-8.77(d,2H);
(22S)(L}2{3-pyrida~ryl} 1-hydmxymethyl-2=WdtrvhmyOWdmxydhynlamide 'HNMR (DMSO, 400MHz) 8: 3.17-3.18(m,1 H), 3.25-3.28(m, l H), 3.50-3.52(m, I
H), 3.65-3 .68(t, I H), 3.70-3 .72(d, I H), 4.73-4.77(t, I H), 7.43-7.45(t,114), 7.61 -7.63(t, I H), 7.64-7.67(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 8.09-8.11 (d, I H), 8.17-8.20(d,2H), 9.34-9.37(d, I H);

((L)-241-h'dmVnwdrA2p'~1 'HNMR (DM SO, 400MHz) 6: 3.17-3.1 8(m, l H), 3.25-3.28(m,1 H), 3.50-3.52(m, I
H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.1 3(d,2H), 7.43-7.45(t, I H), 7.61-7.63(t,1 H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 8.09-8.11(d, I H), 9.34-9.37(d, I H);

( -(3py }1H-~aamlea-[N-(1-nwdrA2-p hioropl>e<,ykdmxydhyl)lamide 'HNMR (DMSO, 400MHz) 8: 1.12-1.15(d,3H), 3.25-3.28(m,IH), 3.65-3.68(t,IH), 4.73-4.77(t, I H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, I H), 7.61 -7.63(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.09-8.11 (d, I H), 9.34-9.37(d, I H);

(228 )2{3-I"idaznyl}III benamida7Ale 4-(N-N'-piperdinylpmide 'HNMR (DMSO, 400MHz) 8: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t, I H), 7.61 -7.63 (t, l H), 7.89-7.91(d,1 H), 7.93-7.94(d,1 H), 8.09-8.11 (d, I H), 9.34-9.37(d,1 H);

(229)2{3-pyridaanyl)-1H-bet midauk-4-(N 2-piperaanylpmide 'HNMR (DMSO, 400MHz) 8: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,IH), 2.69-2.70(m, I H), 2.72-2.74(m, I H), 2.77-2.80(m, I H), 3.02-3.05(m, I H), 3.99-4.01 (m, l H), 7.43-7.45(t, I H), 7.61 -7.63 (t, I H), 7.89-7.91(d,1 H), 7.93-7.94(d,1 H), 8.09-8.11(d,1 H), 9.34-9.37(d, l H) ;

(230 )2{3-pyridaiinyl}1H4xnhmidazok -(N-2'-be nidazolyl amide 'HNMR (DMSO, 400MHz) 6: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, l H), 7.61-7.63(t, I H), 7.89-7.91(d, l H), 7.93-7.94(d, l H), 8.09-8.11(d, l H), 9.34-9.37(d, l H);
(231)2-(3-pyridaziny4-1H bermmida k- -(N-o-aminopbenyl)amide 'HNMR (DMSO, 400MHz) 8: 6.27(s,2H), 6.38-6.40(d, l H), 6.56-6.58(t, l H), 6.75-6.76(d, I H), 7.02-7.04(t, I H), 7.43-7.45(1, l H), 7.61-7.63(t, ]H), 7.89-7.91(d, I H), 7.93-7.94(d,1 H), 8.09-8.11 (d, I H), 9.34-9.37(d, I H) ;

(232)2{3-pyridaz ny¾1H-ben> mida7Ak-4-(~

'HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,IH), 6.93(s,IH), 7.43-7.45(t,1H), 7.54-7.56(d, l H), 7.61 -7.63(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.09-8.11 (d, I H), 9.34-9.37(d, l H);

(233)2-Q-py idazryl}u3-bem n idazole-a-(N-4'-ray-bonamid).-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, l H), 7.61-7.63(t, l H), 7.89-7.91(d, I
H), 7.93-7.94(d, I H), 8.09-8.11 (d, I H), 8.37(s,2H), 9.24-9.26(d, I H), 9.34-9.37(d, I H), 13.00-13.03(d, l H);

(234)2-(3 j idazinyl}1H benrimidazole4-(N-4'-pyrazo1yl)amide ' HNMR (DMSO, 400MHz) 8: 7.43-7.45(t, I H), 7.61 -7.63(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.09-8.11 (d,1 H), 8.61 (s, I H), 8.63-8.65(d, l H), 9.34-9.37(d, I H), 13.71-13.75(d,IH);

(235)2-(3-pyridazinyl}1H berrzimidazoIe 4-(N-(N'-piperaz;nynpmide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t, l H), 7.61 -7.63(t, l H), 7.90-7.91 (d. l H), 7.93-7.94(d,I H) , 8.09-8.11 (d, l H), 9.34-9.37(d,IH);

(236)2-O yi)-1H bmAmMazok4-(N-Ipf de 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,IH), 7.61-7.63(t,1H), 7.89-7.91(d,IH), 7.93-7.94(d,I H), 8.09-8.11 (d, I H), 8.34-8.35(d, l H), 8.36(s,1 H), 8.40-8.42(d, I H), 9.34-9.37(d, I H);

(237 {3-PY ` yly H-bm midazok 4-(N 2- ff imWkWI `mide 'HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,IH), 7.43-7.45(t,IH), 7.61-7.63(t,IH), 7.89-7.91(d,1 H), 7.93-7.94(d,1 H), 8.09-8.11(d, l H), 8.45-8.46(d,2H), 9.34-9.37(d, I H);
(238A{3-1~yl}1H-beimmid~(N 2Ty'iidy4amide 'HNMR (DMSO, 400MHz) 8: 6.62-6.64(t,1 H), 6.70-6.72(d, I H), 7.43-7.45(t, I
H), 7.55-7.57(t,1 H), 7.61-7.63(t,1 H), 7.89-7.91(d, l H), 7.93-7.94(d, I H), 8.07-8.09(d, I H), 8.11-8.13(d,1H), 8.59-8.60(d,IH);

(239 )2-(3-pyrida iny¾1H-benamida7Ale-4(N-4-mefryl-S-t iazolyl amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.43-7.45(t,IH), 7.61-7.63(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.09-8.11 (d, I H), 8.12(s, I H), 9.34-9.37(d, I H);
(24OP(Siiy rich yl}1H-benamidanok=4-(N-2,4-dihydmxy-Siryivnicliny1)amide 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.82(s, I H), 7.93-7.94(d, I H), 8.09-8.11 (d, I H), 8.33(s, I H), 9.34-9.37(d, I H), 11.53(s, I H);
(241)2-(SVyrWaziny¾1H-bmhm; bmk-4-(Nitk4finethoxy-2rlWfimk nyl)amide 'HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s, l H), 7.43-7.45(t, l H), 7.61-7.63(t, l H), 7.89-7.91(d, l H), 7.93-7.94(d,1 H), 8.09-8.11(d, l H), 9.34-9.37(d, I H) ;
(242)2-(3-pyr Wazin l}1H hbro 6 amuro-2-pynmictirryl)amide 'HNMR (DMSO, 400MHz) 6: 5.98(s, I H), 7.43-7.45(t, I H), 7.61-7.63(t, I H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.09-8.11 (d, I H), 9.34-9.37(d, I H);
(243)2-(3-pyridazinyl}1 H-benzimidamk-4-(N-,"chlom-5-pyrvtridinyl)arnide ' HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, l H), 7.61-7.63(t, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, l H), 8.09-8.11(d, I H), 9.32(s, I H), 9.34-9.37(d,I H);

(244)x(3-pyridaiin)-1I -berramidazole4-(N-o-fluomphenyl)amide ' HNMR (DMSO, 400MHz) 6: 6.60-6.61(d, l H), 6.63-6.65(t,1 H), 6.96-6.98(t, l H), 6.99-7.01(d,1 H), 7.43-7.45(t, l H), 7.61 -7.63(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.09-8.11 (d, I H), 9.34-9.37(d, I H);

(245 (3-lryrkLqAnyl)-1H bewimidazole4-(N-2-hydn)Vl -pyrirniduryl)arrride 'HNMR (DMSO, 400MHz) S: 5.46-5 .48(d, I H), 7.10-7.11 (d, I H), 7.43-7.45(t, I
H), 7.61-7.63(t, I H), 7.82(s, I H), 7.89-7.91 (d,1 H), 7.93-7.94(d, l H), 8.09-8.11 (d, I H), 9.34-9.37(d, l H);

(246{3-Piridahnyl}'1H-benamidazok-4-(N-6i-purinyl)amide 'HNMR (DMSO. 400MHz) 6: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.86-7.88(d,IH), 7.89-7.91(d, l H), 7.93-7.94(d, l H), 8.09-8.11(d, I H), 8.16-8.18(d, l H), 9.34-9.37(d, I H);

(247 (3-pycidazmyl}1H-bermmidazole-4{N-6hydmxyl-2-pwvryl)amide 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,IH), 7.61-7.63(t,1H), 7.89-7.91(d,IH), 7.93-7.94(d, I H), 8.09-8.11 (d, I H), 8.57-8.59(d,1 H), 9.34-9.37(d, I H), 11.53(s,1 H);
(7A8)(L}~{4-Py~ida~yl} 1-l>~fiOacyrne~yp2-p-nitr'oPl>~nYltrydroxYet~amide 'HNMR (DMSO, 400MHz) 6: 3.17-3.18(m,1H), 3.25-3.28(m,IH), 3.50-3.52(m,IH), 3.65-3.68(t,IH), 3.70-3.72(d,IH), 4.73-4.77(t,1H), 7.43-7.45(t,IH), 7.62-7.65(d,2H), 7.77-7.80(d,1 H), 7.89-7.90(d, I H), 7.93-7.95(d,1 H), 8.17-8.20(d,2H), 9.30-9.32(d, l H), 9.46(s,IH);

(249)(L)-2-(4-pyriaazniYl} [ 14iJdm pn&y~ ~ YmY' mxy lamiae 'HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3.65-3.68(1, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, I H), 7.77-7.80(d, I H), 7.89-7.90(d, l H), 7.93-7.95(d,1 H), 9.30-9.32(d, I H), 9.46(s,I H);

(250 0{4-lryriclaanyl}1H-berAmidazole 4 (N-2-piperahryf mide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,1H), 2.69-2.70(m,1 H), 2.72-2.74(m, I H), 2.77-2.80(m, l H), 3.02-3.05(m,1 H), 3.99-4.01 (m, I H), 7.43-7.45(t, l H), 7.77-7.80(d, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 9.30-9.32(d, I H), 9.46(s, l H);

(251 )2{ nyn 'HNMR (DMSO, 400MHz) S: 6.93-6.95(t, I H), 7.43-7.45(t, I H), 7.77-7.80(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.45-8.46(d,2H), 9.30-9.32(d, l H), 9.46(s, l H);
(252)(t.}2-PTyraz VktH-be nidazole-4[ 14iydm yl-2i nit MimWkdroxy lamide ' HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, I H), 3.25-3.28(m, ] H), 3.50-3.52(m,1 H), 3 .65-3.68(t, I H), 3.70-3 .72(d, ] H), 4.73-4.77(t, I H), 7.43-7.45(t, ]H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 8.17-8.20(d,2H), 8.76-8.79(d,2H), 9.34(s, I H);

(253)(I } (2i)ry'razmyl}1H4wnAukl<< "&44P,~{1.1iydroxymdhyl-2-p-a~nyltrydroxydhy4 amide ' HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, I H), 3.25-3.28(m, I H), 3.50-3.52(m, I
H), 3.65-3 .68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, l H), 7.89-7.90(d, l H), 793-7.95(d, l H), 8.76-8.79(d,2H), 9.34(s,IH);

Q54g(lPyraiU IH-bmhmk azok4-[N{I-m&yl-2 )-J&Yophenyffiydmxyehyl)]amide 'HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 3.25-3.28(m,IH), 3.65-3.68(t,1H), 4.73-4.77(t,I H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l n), 8.76-8.79(d,2H), 9.34(s, I H);

(255; 1~ bermmkkuok-4-(N-N'i*riffiy>pmide 'HNMR (DMSO, 400MHz) 8: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t, I H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 8.76-8.79(d,2H), 9.34(s, I H); .

(256 2-(2~ IH bwhmk a"e4-{N-2-~ k 'HNMR (DMSO, 400MHz) 8: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,1H), 2.69-2.70(m, I H), 2.72-2.74(m, l H), 2.77-2.80(m,1 H), 3.02-3.05(m, l H), 3.99-4.01(m,1 H), 7.43-7.45(t. I H), 7.89-7.91 (d, l H), 7.93-7.94(d,1 H), 8.76-8.79(d,2H), 9.34(s, I H);

(25T-P-py ryktH kudmidazklc 4 N 2'-bcn imidazolyl)amide ' HNMR (DMSO, 400MHz) 6: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.89-7.91(d.1 H), 7.93-7.94(d, I H) , 8.76-8.79(d,2H), 9.34(s, l H);

lH-'HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,IH), 6.56-6.58(t,IH), 6.75-6.76(d, I H), 7.02-7.04(t, l H), 7.43-7.45(t, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, l H), 8.76-8.79(d,2H), 9.34(s.1 H);
(2 C~-~y,~zo>~yt}

'HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s,IH), 7.43-7.45(t,IH), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.76-8.79(d,2H), 9.34(s, l H);

(260)2 (2 yrah yl}1H4b> iidazole 4-(N-4'-carbonamido-5'-nnida'rolylpmide 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.89-7.91(d,IH), 7.93-7.94(d,1H), 8.37(s,2H), 8.76-8.79(d,2H), 9.24-9.26(d, I H), 9.34(s, I H), 13.00-1 3.03(d, I H);
(261)2-gTyrjz~Yl}1H4bermmid~(N 4'Tyrazolyl)Amide 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.61 (s, I H), 8.63-8.65(d, I H), 8.76-8.79(d,2H), 9.34(s, I H), 13.71-I
3.75(d, I H);

-P4w oY
'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t, l H), 7.90-7.91 (d, I H), 7.93-7.94(d, l H), 8.76-8.79(d,2H), 9.34(s, I H);
(263)2-(Ii)y,azuryl} 2rpyra nyl)an de 'HNMR (DMSO, 400MHz) 8: 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.34-8.35(d, I H), 8.36(s, l H), 8.40-8.42(d, l H), 8.76-8.79(d,2H), 9.34(s, I
H);

(2 4)2-(Z-pYra&*IH bermmidazde44-(N-2-pyiimidinyl)~unicle 'HNMR (DMSO, 400MHz) 6: 6.93-6.95(t, l H), 7.43-7.45(t, l H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.45-8.46(d,2H), 8.76-8.79(d,2H), 9.34(s, I H);

(265)2-(2 pyrazoryl} 2-pyiidyi)amide 'HNMR (DMSO, 400MHz) 8: 6.62-6.64(t, l H), 6.70-6.72(d,1 H), 7.43-7.45(t, l H), 7.55-7.57(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.07-8.09(d, l H), 8.76-8.79(d,2H), -9.34(s,I H);

(26 1H bermmidawk4-(N-0-methy{-5-thiazolyl imide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.43-7.45(t,IH), 7.89-7.91(d,IH), 7.93-7.94(d. I H), 8.12(s, I H), 8.76-8.79(d,2H), 9.34(s, I H);

(267)x{2 py vinyl)- H-bewimidazole-4(N-2,4 dihydmxyl-5-Iryrunidinyl)amile 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, I H), 7.89-7.91(d,1 H), 7.82(s, I H), 7.93-7.94(d, I H), 8.33(s, I H), 8.76-8.79(d,2H), 9.34(s, I H), 11.53(s, I H);

*M-beniim da~~,6-dimethoxy 2-p iimidh amide 'HNMR (DMSO, 400MHz) 8: 3.82(s,6H), 5.71(s, l H), 7.43-7.45(t, I H), 7.89-7.91(d, I H), 7.93-7.94(d,I H), 8.76-8.79(d,2H), 9.34(s, I H);

(269 1H m.6-amino-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 5.98(s, l H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.76-8.79(d,2H), 9.34(s, I H);

(270 X1(2-py winy-lH-bewmmidawk44{1*4,6-dichlono-s_ffrit myf mile 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I
H), 8.76-8.79(d,2H). 9.34(s,1 H), 9.37(s, I H);

(271 ',-(2 'r`ahnyl}M4mWn i bmk 4 *o-fimmowgl~un ' HNMR (DMSO, 400MHz) 6: 6.60-6.61 (d, l H), 6.63-6.65(t, I H), 6.96-6.98(t, I
H), 6.99-7.01 (d, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.76-8.79(d,2H), 9.34(s,1 H);

(272 1H-be nidazok4-(N-2rhydruVW pyrhrtidi tmide ' HNMR (DMSO, 400MHz) 8: 5.46-5.48(d, I H), 7.10-7.11(d, I H), 7.43-7.45(t, l H), 7.82(s,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.76-8.79(d,2H), 9.34(s, I
H);

' HNMR (DMSO, 400MHz) 6: 7.43-7.45(t.] H), 7.86-7.88(d, l H), 7.89-7.91(d,1 H), 7.93-7.94(d,1 H), 8.16-8.18(d, l H), 8.76-8.79(d,2H), 9.34(s, I H);

(274)2-(2-lryratryl}1 dmxyl-2-lw in~
' HNMR (DMSO, 400MHz) S: 7.43-7.45(t, l H), 7.89-7.91(d, l H), 7.93-7.94(d, l H), 8.57-8.59(d, I H), 8.76-8.79(d,2H), 9.34(s, I H), 11.53(s, I H);
(275)(LY2-(2iiperaanyl}1H-beimrr>idazde-4[N{1-hydmxymethyl-2rp nihvphei ylhydmxyethyn]amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1 H), 2.72-2.74(m, l H), 2.84-2.86(m, l H), 3.09-3.11(m,1 H), 3.17-3.1 8(m, I H), 3.25-3.28(m, I H), 3.50-3.52(m,1 H), 3.65-3.68(t, l H), 3.70-3.72(d,1 H), 4.14-4.1 7(m, I H), 4.73-4.77(t, l H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 8.17-8.20(d.2H);

(276)(L} (2-piperaanyl)-1H-bermrrud~[N-(14iydmxym 2,"mnwphenyIlrydmxy ]amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m, l H), 2.72-2.74(m,1 H), 2.84-2.86(m, l H), 3.09-3.1 1(m,1 H), 3.17-3.1 8(m, l H), 3.25-3.28(m,1 H), 3.50-3.52(m, I H), 3.65-3.68(t, l H), 3.70-3.72(d, l H), 4.14-4.1 7(m, l H), 4.73-4.77(t, l H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.1 3(d,2H), 7.43-7.45(t, l H), 7.89-7.90(d, I H), 793-7.95(d, I H);

(277)2-(2 piperazinyl}1H-baAnidazok-4-[N{1-mctlryl-2-p-ddmoo myllrydmxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m, I H), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.84-2.86(m,1 H), 3.09-3.11 (m, I H), 3 .25-3.28(m, I H), 3.65-3 .68(t, I H), 4.14-4.1 7(m, l H), 4.73-4.77(t, l H), 7.29-7.30(d,2H), 7.40-7.4 1 (d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H);

(278)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.91-1.93(m,2H), 2.62-2.63(m, l H), 2.65-2.66(m, I H), 2.69-2.70(m,1 H), 2.72-2.74(m, I H), 2.84-2.86(m, I H), 3.09-3.11 (m, ] H), 3.13-3.1 5(m, l H), 4.14-4.17(m,I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(279)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.9I-1.93(m,4H), 2.62-2.63(m,2H), 2.65-2.66(m,2H), 2.69-2.70(m,2H), 2.72-2.74(m,2H), 2.77-2.80(m, I H), 2.84-2.86(m, l H), 3.02-3.05(m,1 H), 3.09-3.11 (m, l H), 3.99-4.0 I (m, l H), 4.14-4.1 7(m, I H), 7.43-7.45(t, I
H), 7.89-7.91(d, I H), 7.93-7.94(d,] H);

(280)2-(2-pi perazinyl)-1 H-benzimidazole-4-(N-2'-benzi midazolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m, I H), 2.72-2.74(m, I H), 2.84-2.86(m,1 H), 3.09-3.11 (m, I H), 4.14-4.1 7(m, I H), 7.1 2-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(281)2-(2-piperazinyl)-1H-benzimidazole-4-(N-o-a minophenyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m, ] H), 2.72-2.74(m,1 H), 2.84-2.86(m, l H), 3.09-3.11 (m, l H), 4.14-4.1 7(m, ] H), 6.27(s,2H), 6.3 8-6.40(d, I H), 6.56-6.5 8(t,1 H), 6.75-6.76(d, I H), 7.02-7.04(t, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(282)2-(2-pi perazi nyl)-1 H-benzim idazole-4-(N-5-benzimidazolonyl)am ide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,]H), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.84-2.86(m, ] H), 3.09-3.11 (m, l H), 4.14-4.1 7(m, I H), 6.35-6.37(d, l H), 6.93(s, I H), 7.43-7.45(t, l H), 7.54-7.56(d,1 H), 7.89-7.91(d, l H), 7.93-7.94(d, I H);

(283)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m, I H), 2.65-2.66(m,1 H), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.84-2.86(m, l H), 3.09-3.11 (m, l H), 4.14-4.1 7(m, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.37(s,2H), 9.24-9.26(d, I H), 13.00-13.03(d, I H) ;

(284)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m, I H), 2.72-2.74(m, I H), 2.84-2.86(m, I H), 3.09-3.1 1(m, l H), 4.14-4.17(m,1 H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.61 (s, I H), 8.63-8.65(d,1 H), 13.71-13.75(d,I H);

(285)2-(2-pi perazinyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 1.94-1.95(m,IH), 2.62-2.63(m,IH), 2.65-2.67(t,5H), 2.69-2.70(m, l H), 2.72-2.74(m,1 H), 2.80-2.83(m,4H), 2.84-2.86(m, I H), 3.09-3.11(m, I H), 4.14-4.17(m, l H), 7.43-7.45(t, l H), 7.90-7.91 (d, l H), 7.93-7.94(d,1 H);
(286)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.93(m,2H), 2.62-2.63(m, l H), 2.65-2.66(m,1 H), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.84-2.86(m, I H), 3.09-3.11(m,1 H), 4.14-4.1 7(m, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.34-8.35(d, l H), 8.36(s, I H), 8.40-8.42(d, l H) ;

(287)2-(2-pi perazinyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m, l H), 2.65-2.66(m, I H), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.84-2.86(m,1 H), 3.09-3.11 (m, l H), 4.14-4.1 7(m, l H), 6.93-6.95(t,1 H), 7.43-7.45(t, I H), 7.89-7.91 (d,1 H), 7.93-7.94(d,1 H), 8.45-8.46(d,2H);
(288)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,1H), 2.69-2.70(m,1 H), 2.72-2.74(m, I H), 2.84-2.86(m, I H), 3.09-3.11 (m, I H), 4.14-4.1 7(m, I H), 6.62-6.64(t, ]H), 6.70-6.72(d, I H), 7.43-7.45(t, I H), 7.55-7.57(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.07-8.09(d, I H);

(289)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-4-methyl-5-th iazolyl)a m ide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.45(s,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1 H), 2.65-2.66(m,1 H), 2.69-2.70(m,1 H), 2.72-2.74(m. I H), 2.84-2.86(m, l H), 3.09-3.1 1(m, I H), 4.14-4. 17(m, l H), 7.43-7.45(t,1 H), 7.89-7.91(d, l H), 7.93-7.94(d, I H), 8.12(s, I H);

(290)2-(2-piperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m,1 H), 2.72-2.74(m.1 H), 2.84-2.86(m, l H), 3.09-3.11 (m, I H), 4.14-4. 17(m, l H), 7.43-7.45(t, l H), 7.89-7.91 (d,1 H), 7.82(s, I H), 7.93-7.94(d,1 H), 8.33(s,1 H), 11.53(s, I H);
(291)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,IH), 2.69-2.70(m, I H), 2.72-2.74(m, I H), 2.84-2.86(m, I H), 3.09-3.11 (m, I H), 3.82(s,6H), 5.71 (s, I H), 4.14-4.17(m, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H) ;
(292)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,IH), 2.69-2.70(m,1 H), 2.72-2.74(m, l H), 2.84-2.86(m,1 H), 3.09-3.1 1(m, l H), 4.14-4.1 7(m, I H), 5.98(s, I H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(293)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.84-2.86(m, I H), 3.09-3.11 (m, I H), 4.14-4.1 7(m, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.34(s, l H);

(294)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m, I H), 2.65-2.66(m, l H), 2.69-2.70(m, I H), 2.72-2.74(m, l H), 2.84-2.86(m, l H), 3.09-3.11 (m, I H), 4.14-4.17(m, l H), 6.60-6.61 (d, I H), 6.63-6.65(t, I H), 6.96-6.98(t,1 H), 6.99-7.01 (d, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H) ;

(295)2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide i HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m, I H), 2.65-2.66(m, I
H), 2.69-2.70(m,1 H), 2.72-2.74(m, I H), 2.84-2.86(m,I H), 3.09-3.11(m,I H), 4.14-4.17(m, I H), 5.46-5.48(d,1 H), 7.10-7.11 (d, I H), 7.43-7.45(t, l H), 7.82(s, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);

(296)2-(2-piperazinyl)-1 H-benzimidazole-4-(N-6-purinyl)amide ' HNMR . (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m, l H), 2.65-2.66(m, l H), 2.69-2.70(m, l H), 2.72-2.74(m,1 H), 2.84-2.86(m, I H), 3.09-3.11 (m, I H), 4.14-4.1 7(m, I H), 7.43-7.45(t,1 H), 7.86-7.88(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.16-8.18(d, I H);
(297)2-(2-piperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-pu rinyl)amide ' HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m, l H), 2.65-2.66(m, l H), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.84-2.86(m,1 H), 3.09-3.11 (m, l H), 4.14-4.1 7(m, I H), 7.43-7.45(t,1 H), 7.89-7.91(d,1 H), 7.93-7.94(d,1 H), 8.57-8.59(d, l H), 11 .53(s, I H);
(298)(L)-2-(N,N'-diethyl-2-piperazinyl)-1 H-benzimidazole-4-IN-(1-hydroxymethyl-2-p -nitrophenylhydroxyethyl)lamide 'HNMR (DMSO, 400MHz) 6: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,IH), 2.65-2.67(t, l H), 2.69-2.71(t, I H), 2.72-2.74(t,1 H), 2.76-2.78(t, l H), 2.88-2.90(d, I H), 3.17-3.1 8(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m, l H), 3.65-3.68(t,1 H), 3.70-3.72(d, I H), 4.14-4.1 6(t, l H), 4.73-4.77(t, I H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 8.17-8.20(d,2H);

(299)(L)-2-(N,N'-diethyl-2-piperazinyl)-1 H-benzim idazole-4-[N-(1-hydroxymethyl-2-p -aminophenylhydroxyethyl)lamide 'HNMR (DMSO, 400MHz) 6: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61-2.63(d,iH), 2.65-2.67(t, I H), 2.69-2.71 (t, I H), 2.72-2.74(t, l H), 2.76-2.78(t, l H), 2.88-2.90(d, l H), 3.17-3.1 8(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m, I H), 3.65-3.68(t, I H), 3.70-3.72(d, l H), 4.14-4.16(t, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d, I H);

(300)2-(N,N'-diethyl-2-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.02-1.06(t,6H), 1.91-1.93(m,2H), 2.40-2.43(m,4H), 2.59-2.60(d, I H), 2.62-2.63(m, l H), 2.64-2.65(t, I H), 2.66-2.67(m, l H), 2.68-2.70(t,2H), 2.72-2.73(m,1 H), 2.74-2.75(t, I H), 2.76-2.78(t, I H), 2.77-2.80(m,1 H), 2.88-2.90(d, I H), 3 .02-3.05(m, I H), 3.99-4.01 ,m, I H), 4.14-4.1 6(t, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H);

(301)2-(N,N'-diethyl-2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.02-1.06(t,6H), 2.40-2.43(m,4H), 2.61 -2.63(d, l H), 2.65-2.67(t, l H), 2.69-2.71(t,1 H), 2.72-2.74(t, l H), 2.76-2.78(t, IH), 2.88-2.90(d, l H), 4.14-4.16(t, l H), 6.93-6.95(t, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d,1 H), 8.45-8.46(d,2H);

(302)(L)-2-(N-piperazinyl)-1H-benzimidazole-4-[N-(1-hyd roxymethyl-2-p-nitrophenyl hydroxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,IH), 2.78-2.82(m,4H), 3.15-3.16(m,IH), 3.18-3.22(t,4H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t,1 H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, I H), 7.93-7.95(d, l H), 8.17-8.20(d,2H);

(303)(L)-2-(N-piperazinyl)-1H-benzimidazole-4-[N-(I-hydroxymethyl-2-p-aminopheny lhydroxyethyl)]amide ' HNMR (DMSO, 400MHz) 6: 1.91-1 .92(m, I H), 2.78-2.82(m,4H), 3.15-3.1 6(m, ]
H), 3.18-3.22(t,4H), 3.25-3.28(m, I H), 3.50-3.52(m, I H), 3.65-3.68(t,1 H), 3.70-3.72(d, l H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H). 7.11-7.13(d,2H), 7.43-7.45(t, ] H), 7.89-7.90(d, I H), 7.93-7.95(d, I H);

(304)2-(N-piperazinyl)-I H-benzimidazole-4-[N-(I -methyl-2-p-ch lorophenylhyd roxyeth yl)]amide ' HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.91-1.92(m,1 H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 3.25-3.28(m, l H), 3 .65-3.68(t, ] H), 4.73-4.77(t, I H), 7.29-7.30(d,2H), 7.40-7.41 (d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(305)2-(N-piperazinyl)-1 H-benzimidazole-4-(N-N'-piperid inyl)amide 'HNMR (DMSO, 400MHz) 8: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.10-3.15(t,4H), 3.17-3.22(t,4H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d,] H);

(306)2-(N-piperazinyl)-1 H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,3H), 2.62-2.63(m,]H), 2.65-2.66(m,IH), 2.69-2.70(m, ] H), 2.72-2.74(m, I H), 2.78-2.82(m,5H), 3.02-3.05(m, I H), 3.17-3.22(t,4H), 3.99-4.01 (m,1 H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H) ;

(307)2-(N-piperazinyl)-1 H-benzi midazole-4-(N-2'-benzi midazolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-I .92(m, I H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);
(308)2-(N-piperazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,IH), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.27(s,2H), 6.38-6.40(d, I H), 6.56-6.58(t, I H), 6.75-6.76(d, I H), 7.02-7.04(t, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H);

(309)2-(N-piperazinyl)-1 H-benzimidazole-4-(N-5-benzim idazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,IH), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.35-6.37(d,1 H), 6.93(s, I H), 7.43-7.45(t, I H), 7.54-7.56(d,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H) ;

(310)2-(N-piperazinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,IH), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H), 8.37(s,2H), 9.24-9.26(d, l H), 13.00-13.03(d, I H);

(311 )2-(N-piperazinyl)-1 H-benzi midazole-4-(N-4'-pyrazolyl)a mide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,IH), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.61(s, I H), 8.63-8.65(d,1 H), 13.71-13.75(d,IH);

(312)2-(N-piperazinyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,2H), 2.65-2.67(t,4H), 2.78-2.80(m,4H), 2.81-2.83(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t, l H), 7.90-7.91 (d, I H), 7.93-7.94(d, I H);
(313)2-(N-piperazinyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1 .92(m, I H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.34-8.35(d, l H), 8.36(s, I H), 8.40-8.42(d, l H);

(314)2-(N-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,IH), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.93-6.95(t, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.45-8.46(d,2H);
(315)2-(N-piperazinyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.92(m,IH), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.62-6.64(t, l H), 6.70-6.72(d, I H), 7.43-7.45(t, l H), 7.55-7.57(t, l H), 7.89-7.91(d, l H), 7.93-7.94(d, l H), 8.07-8.09(d, I H);

(316)2-(N-piperazinyl)-1 H-benzi m idazole-4-(N-4-methyl-5-thiazolyl)am ide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,IH), 2.45(s,3H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.12(s, l H);
(317)2-(N-piperazinyl)-1 H-benzimidazole-4-(N-2,4-dihyd roxyl-5-pyrimidinyl)amide i HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1 H), 2.78-2.82(m,4H), 3.1 7-3.22(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.82(s, l H), 7.93-7.94(d,1 H), 8.33(s.] H), 11 .53(s, l H);
(318)2-(N-piperazinyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 3.82(s,6H), 5.71(s,lH), 7.43-7.45(t,1H), 7.89-7.91(d,IH), 7.93-7.94(d,1H);
(319)2-(N-piperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrim idinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,IH), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 5.98(s, l H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);
(320)2-(N-piperazinyl)-1 H-benzi midazole-4-(N-4,6-d ichloro-5-pyrimidinyl)a mid e 'HNMR (DMSO, 400MHz) 6: 1.91-1 .92(m, l H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t, l H), 7.89-7.91(d,1 H), 7.93-7.94(d, l H), 9.34(s, l H) ;
(321)2-(N-piperazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m, I H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.60-6.61 (d, l H), 6.63-6.65(t, l H), 6.96-6.98(t, l H), 6.99-7.01 (d, l H), 7.43-7.45(t, l H), 7.89-7.91(d, I H), 7.93-7.94(d, l H);

(322)2-(N-piperazinyl)-1 H-benzi m idazole-4-(N-2-hydroxyl-4-py ri midinyl)a mid e 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,IH), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 5.46-5.48(d, I H), 7.10-7.11 (d, l H), 7.43-7.45(t, l H), 7.82(s, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H);

(323)2-(N-piperazinyl)-1 H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t, I H), 7.86-7.88(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.16-8.1 8(d, I H);
(324)2-(N-piperazinyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.57-8.59(d, I H), II .53(s,1 H);
(325)(L)-2-(N-ethyl-N'-piperazinyl)-1 H-benzi m idazole-4-IN-(1-hyd roxymethyl-2-p-nit rophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) S: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.19-3.21 (m, l H), 3.25-3.28(m, I H), , 3.44-3.46(t,4H), 3.50-3.52(m, I H), 3 .65-3.68(t, I H), 3 .70-3.72(d, l H), 4.73-4.77(t, I H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d,IH), 8.17-8.20(d,2H);

(326)(L)-2-(N-ethyl-N'-piperazinyl)-I H-benzi midazole-4-[N-(1-hyd roxymethyl-2-p-a m inophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3. 19-3.21(m, I H), 3.25-3.28(m, I H), 3.44-3.46(t,4H), 3.50-3.52(m,1 H), 3.65-3.68(t, l H), 3.70-3.72(d,1 H), 4.73-4.77(t, l H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1 H), 7.89-7.90(d, I H), 7.93-7.95(d, I H);

(327)2-(N-ethyl-N'-piperazinyl)-I H-benzim idazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.02-1.05(t,3H), 1.91-1.93(m,2H), 2.38-2.41(m,2H), 2.62-2.36(m, l H), 2.65-2.66(m, l H), 2.69-2.70(m,1 H), 2.72-2.74(m,1 H), 2.77-2.80(m,1 H), 3 .02-3.05(m, I H), 3.15-3.17(t,4H), 3.44-3.46(t,4H), 3.99-4.01 (m, I H), 7.43-7.45(t, I H), 7.89-7.91(d, l H), 7.93-7.94(d, l H) ;

(328)2-(N-ethyl-N'-piperazinyl)-lH-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.44-3.46(t,4H), 6.93-6.95(t, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.45-8.46(d,2H);

(329)(L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhyd roxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,IH), 3 .65-3.68(t, I H), 3.70-3 .72(d, I H), 4.73-4.77(t, I H), 6.15-6.1 8(t, I H), 6.40-6.42(d, l H), 6.95-6.97(d, l H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, l H), 8.17-8.20(d,2H);

(330)(L)-2-(2-py rrolyl)-1 H-benzi m id azole-4- [N-(1-hyd roxymethyl-2-p-a m i n op h eny l by droxyethyl)]amide ' HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, I H), 3.25-3.28(m, l H), 3.50-3.52(m, l H), 3 .65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.15-6.1 8(t, l H), 6.40-6.42(d, I H), 6.27(s,2H), 6.56-6.58(d,2H), 6.95-6.97(d, I H), 7.11-7.13(d,2H), 7.43-7.45(t, l H), 7.89-7.90(d,1 H), 7.93-7.95(d, I H);

(331)2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) S: 1.12-1.15(d,3H), 3.25-3.28(m, l H), 3.65-3.68(t, l H), 4.73-4.77(t, l H), 6.15-6.1 8(t, l H), 6.40-6.42(d, l H), 6.95-6.97(d, l H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,IH), 7.89-7.91(d,IH), 7.93-7.94(d,1H);
(332)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 6.15-6.1 8(t, I H), 6.40-6.42(d, I H), 6.95-6.97(d, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H);

(333)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m, I H), 2.72-2.74(m, I H), 2.77-2.80(m, I H), 3 .02-3.05(m, I H), 3.99-4.01 (m, I H), 6.15-6.1 8(t, l H), 6.40-6.42(d, l H), 6.95-6.97(d, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);

(334)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DM SO, 400MHz) 8: 6.15-6.1 8(t, I H), 6.40-6.42(d, l H), 6.95-6.97(d, I
H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,IH), 7.93-7.94(d,1H);
(335)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 6.15-6.18(t,IH), 6.27(s,2H), 6.38-6.39(d,IH), 6.40-6.42(d, I H), 6.56-6.58(t, I H), 6.75-6.76(d, l H), 6.95-6.97(d, I H), 7.02-7.04(t, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(336)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide ' 1-INMR (DMSO, 400MHz) 6: 6.15-6.18(t,1 H), 6.35-6.37(d, l H), 6.40-6.42(d, I
H), 6.93(s, I H), 6.95-6.97(d, I H), 7.43-7.45(t, l H), 7.54-7.56(d, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);

(337)2-(2-pyrrolyl)-1 H-benzi m idazole-4-(N-4'-ca rbonam ido-5'-i midazolyl)amide 'HNMR (DMSO, 400MHz) 6: 6.15-6.18(t, l H), 6.40-6.42(d, l H), 6.95-6.97(d, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.37(s,2H), 9.24-9.26(d, I H), 13.00-13.03(d,1 H);

(338)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 8: 6.15-6.1 8(t, l H), 6.40-6.42(d, I H), 6.95-6.97(d, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.61 (s, l H), 8.63-8.65(d, I H), 13.71-13.75(d,I H);

(339)2-(2-pyrrolyl)-1 H-benzi midazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.1 5-6.18(t, I H), 6.40-6.42(d, I H), 6.95-6.97(d, I H), 7.43-7.45(t, l H), 7.90-7.91 (d, I H), 7.93-7.94(d,11-1);

(340)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide ' HNMR (DM SO, 400MHz) 8: 6.15-6.1 8(t, l H), 6.40-6.42(d, I H), 6.95-6.97(d, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.34-8.35(d, I H), 8.36(s, I H), 8.40-8.42(d,1 H);

(341)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR(DMSO,400MHz)5:6.15-6.18(t, I H),6.40-6.42(d, I H),6.93-6.95(t, I H), 6.98-7.01 (d. I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.45-8.46(d,2H);
(342)2-(2-pyrrolyl)-1H-benzi midazole-4-(N-2-pyridyl)amide ' HNMR (DMSO, 400MHz) 8: 6.15-6.18(t, I H), 6.40-6.42(d, I H), 6.62-6.64(1, I
H), 6.70-6.72(d,IH), 6.95-6.97(d,IH), 7.43-7.45(t,IH), 7.55-7.57(t,IH), 7.89-7.91(d,IH), 7.93-7.94(d, I H), 8.07-8.09(d, l H);

(343)2-(2-pyrrolyl)-1 H-benzi midazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) S: 2.45(s,3H), 6.15-6.18(t,IH), 6.40-6.42(d,IH), 6.95-6.97(d, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.1 2(s, l H);
(344)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide ' HNMR(DM SO,400MHz)5:6.15-6.18(t, l H),6.40-6.42(d, I H),6.95-6.97(d, l H),7.43-7.4 5(t, I H). 7.89-7.91 (d,IH), 7.82(s, I H), 7.93-7.94(d, I H), 8.33(s,1H), 11.53(s,IH);
(345)2-(2-pyrrolyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR(DM SO,400MHz)6:3.82(s,6H), 5.71 (s, l H), 6.15-6.1 8(t, I H), 6.40-6.42(d, I H), 6.95-6.97(d, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(346)2-(2-py rrolyl)-1 H-benzi m idazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)am ide 'HNMR (DMSO, 400MHz) 8: 5.98(s,IH), 6.15-6.18(t,IH), 6.40-6.42(d,1H), 6.95-6.97(d, I H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H) ;
(347)2-(2-pyrrolyl)-1 H-benzi midazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 8: 6.15-6.18(t, I H), 6.40-6.42(d,1 H), 6.95-6.97(d, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.34(s, I H);

(348)2-(2-pyrrolyl)-1 H-benzi m id azole-4-(N-o-fluorophenyl)amide ' HNMR (DMSO, 400MHz) 6: 6.15-6.1 8(t, I H), 6.40-6.42(d, I H), 6.60-6.61 (d, l H), 6.63-6.65(t, l H), 6.90-6.93(d, l H), 6.96-6.98(t, l H), 6.99-7.01(d,1 H), 7.43-7.45(t, l H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H);

(349)2-(2-pyrrolyl)-I H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide ' HNMR(DMSO,400MHz)5:5.46-5.48(d, I H),6.15-6.18(t, I H),6.40-6.42(d, I
H),6.95-6.9 7(d, I H),7.10-7.11 (d, I H),7.43-7.45(t, I H),7.82(s, I H),7.89-7.91 (d, I
H),7.93-7.94(d, I H) ;
(350)2-(2-py rrolyl)-1 H-benzimidazole-4-(N-6-pu rinyl)a m ide 'HNMR (DMSO, 400MHz) 8: 6.15-6.1 8(t, I H), 6.40-6.42(d, l H), 6.95-6.97(d, I
H), 7.43-7.45(t, l H),7.86-7.88(d, I H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 8.16-8.18(d, l H);
(351)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 8: 6.15-6.18(t,IH), 6.40-6.42(d,IH), 6.95-6.97(d,IH), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.57-8.59(d,1 H), 11 .53(s,1 H);
(352)(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hyd roxymethyl-2-p -nitrophenylhydroxyethyl)] amide ' HNMR (DMSO, 400MHz) 8: 2.45(s,3H), 3.17-3.18(m, I H), 3.25-3.28(m, I H), 3.50-3.52(m, I H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.99(s.2H),7.43-7.45(t,I H), 7.62-7.65(d,2H), 7.89-7.90(d, I H), 7.93-7.95(d,I
H), 8.17-8.20(d,2H);

(353)(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hyd roxymethyl-2-p -aminophenylhydroxyethyl)]amide 'HNMR(DMSO,400MHz)6: 2.45(s,3H), 3.17-3.18(m, I H), 3.25-3.28(m, l H), 3.50-3.52(m, I H), 3.65-3.68(1, l H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d.2H). 6.99(s,2H), 7.11-7.1 3(d,2H), 7.43-7.45(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d,I H);

(354)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophen ylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 2.45(s,3H), 3.25-3.28(m,IH), 3.65-3.68(t, l H), 4.73-4.77(t, I H), 6.99(s,2H), 7.29-7.30(d,2H), 7.40-7.41 (d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(355)2-(4-methyl-5-aminothiazolyl)-1 H-benzi midazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.45(s,3H), 3.10-3.1 5(t,4H), 6.99(s,2H), 7.43-7.45(t,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);
(356)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.93(m,2H), 2.45(s,3H), 2.62-2.63(m,IH), 2.65-2.66(m, I H), 2.69-2.70(m, I H), 2.72-2.74(m, l H), 2.77-2.80(m, I H), 3.02-3.05(m,1 H), 3.99-4.01 (m, I H), 6.99(s,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H);
(357)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-2'-benzi midazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H);

(358)2-(4-methyl-5-a minothiazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.27(s,2H), 6.38-6.40(d,]H), 6.56-6.58(t, I H), 6.75-6.76(d,1 H), 6.99(s,2H), 7.02-7.04(t, I H), 7.43-7.45(t, l H), 7.89-7.91(d,I H), 7.93-7.94(d,I H);

(359)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.35-6.37(d,IH), 6.93(s,IH), 6.99(s,2H), 7.43-7.45(t,1 H), 7.54-7.56(d, I H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H);

(360)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidaz olyl)amide 'HNMR (DMSO, 400MHz) 8: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,]H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.37(s,2H), 9.24-9.26(d, ] H), 13.00-13.03(d, I H);
(361)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.61(s,IH), 8.63-8.65(d,IH), 13.71-13.75(d,I H);
(362)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,IH), 2.45(s,3H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.99(s,2H), 7.43-7.45(t, I H), 7.90-7.91(d, I H), 7.93-7.94(d,1 H);
(363)2-(4-methyl-5-aminothiazolyl)-1 H-benzim idazole-4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,IH), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.34-8.35(d, I H), 8.36(s, I H), 8.40-8.42(d, ] H);
(364)2-(4-methyl-5-ami noth iazolyl)- 1 H-benzi midazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.93-6.95(t,IH), 6.99(s,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.45-8.46(d,2H);
(365)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.62-6.64(t,IH), 6.70-6.72(d,IH), 6.99(s,2H), 7.43-7.45(t, I H), 7.55-7.57(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.07-8.09(d,1 H) ;

(366)2-(4-methyl-5-aminothiazolyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyi)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,6H), 6.99(s,2H), 7.43-7.45(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.12(s,IH);

(367)2{4-methyl-5-aminothiazolyl)-1H-benzimidazole-t-(N-2,4 -dihydroxyl-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t, l H), 7.89-7.91(d,IH), 7.82(s,IH), 7.93-7.94(d,IH), 8.33(s,IH), 11.53(s,1H);

(368)2- (4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 3.82(s,6H), 5.71(s,1H), 6.99(s,2H), 7.43-7.45(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d.1 H);
(369)2{4-methyl-5-aminothiazolyl}1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 5.98(s, l H), 6.99(s,2H). 7.43-7.45(t, l H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H) ;

(370)2{4-methyl-5-aminothiazolyl -1H-benzimidazole-4-(N-,6.dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.34(s, I H);
(371)2-{4-methyl-5-aminothiazolyl}1H-benzimidazole-4-(N-o-0uoropheny4amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.60-6.61(d,IH). 6.63-6.65(t,1H), 6.96-6.97(t, I H), 6.99(s,2H), 7.02-7.05(d, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(372)2{4-methyl-5-aminothiazolyl -1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s.3H), 5.46-5.48(d,IH), 6.99(s,2H), 7.10-7.1 1 (d, I H), 7.43-7.45(t, I H), 7.82(s, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(373)2{4-methyl-5-aminothiazolyl}1 H-benzimidazole-4-(N-6-purinyl)amide (HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.86-7.88(d, l H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 8.16-8.18(d, I H) ;
(374)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole.4-(N--hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t, I H), 7.89-7.91(d,I H), 7.93-7.94(d, l H), 8.57-8.59(d,1 H), 11.53(s,I H);

(375)(L)-2-(2-q u inoli nyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-n itrophenylhy droxyethyl)jamide 'HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, I H), 3.25-3.28(m, I H), 3.50-3.52(m, I
H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 7.39-7.40(d, l H), 7.43-7.45(t,1 H), 7.60-7.62(t, l H), 7.64-7.65(d,2H), 7.76-7.77 (t, I H), 7.89-7.90(d, I H), 7.93-7.95(d, l H), 7.98-8.00(d, I H), 8.06-8.07(d, l H), 8.1 7-8.20(d,2H), 8.44-8.46(d, I H);

(376)(L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(I-hydroxymethyl-2-p-aminophenyl hydroxyethyl))amide ' HNMR (DMSO, 400MHz) S: 3.17-3.18(m, l H), 3.25-3.28(m, ] H), 3.50-3.52(m, I
H), 3 .65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, l H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.39-7.40(d, I H), 7.43-7.45(t, l H), 7.60-7.62(t, I H), 7.78-7.79 (t, I H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 7.98-8.00(d, l H), 8.06-8.07(d, I H), 8.40-8.41 (d, l H), 8.44-8.46(d,1 H);

(377)2-(2-quinolinyl)-1H-benzimidazole-4-IN-(1-methyl-2-p-chlorophenylhydroxyethy ()]amide ' HNMR (DMSO, 400MHz) S: 1.12-1.15(d,3H), 3.25-3.28(m, l H), 3.65-3.68(t, I
H), 4.73-4.77(t, l H), 7.29-7.30(d,2H), 7.3 5-7.37(d, l H), 7.40-7.41(d,2H), 7.43-7.45(t, l H), 7.60-7.62(t, I H), 7.78-7.79 (t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 7.98-8.00(d, I H), 8.06-8.07(d,1 H), 8.44-8.46(d, I H);

(378)2-(2-quinolinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.39-7.40(d, l H), 7.43-7.45(t, l H), 7.60-7.62(t, I H), 7.78-7.79 (t, l H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 7.98-8.00(d, l H), 8.06-8.07(d, I H), 8.44-8.46(d, I H);
(379)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,IH), 2.69-2.70(m, I H), 2.72-2.74(m, ] H), 2.77-2.80(m,1 H), 3.02-3.05 (m, l H), 3.99-4.0 I (m, I H), 7.39-7.40(d,1 H), 7.43-7.45(t, l H), 7.60-7.62(t, I H), 7.78-7.79 (t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 7.98-8.00(d, I H), 8.06-8.07(d, I H), 8.44-8.46(d, I H) ;

(380)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide ' HNMR (DMSO, 400MHz) 6: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.39-7.40(d, l H), 7.43-7.45(t, I H), 7.60-7.62(t, I H), 7.78-7.79 (t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 7.98-8.00(d, I H), 8.06-8.07(d, I H), 8.44-8.46(d, I H) ;
(381)2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide ' HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d, I H), 6.56-6.58(t, l H), 6.75-6.76(d, l H), 7.02-7.04(t, I H), 7.39-7.40(d, I H), 7.43-7.45(t, I H), 7.60-7.62(t, I H), 7.78-7.79 (t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 7.98-8.00(d, l H), 8.06-8.07(d, l H), 8.44-8.46(d, I H);

(382)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide ' HNMR (DMSO, 400MHz) 6: 6.35-6.37(d, I H), 6.93(s, I H), 7.39-7.40(d, l H), 7.43-7.45(t, l H), 7.54-7.56(d, l H), 7.60-7.62(t, l H), 7.78-7.79 (t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 7.98-8.00(d, l H), 8.06-8.07(d, I H), 8.44-8.46(d, I H) ;
(383)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) S: 7.39-7.40(d, ] H), 7.43-7.45(t,1 H), 7.60-7.62(t, l H), 7.78-7.79 (t,1 H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 7.98-8.00(d, l H), 8.06-8.07(d, I H), 8.37(s,2H), 8.44-8.46(d, l H), 9.24-9.26(d, I H), 13.00-13.03(d, I H);
(384)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) S: 7.39-7.40(d, I H), 7.43-7.45(t, l H), 7.60-7.62(t, I
H), 7.78-7.79 (t, l H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 7.98-8.00(d, I H), 8.06-8.07(d, I H), 8.44-8.46(d, I H), 8.61 (s, I H), 8.63-8.65(d,1 H), 13.71-13.75(d, I H);
(385)2-(2-quinolinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) S: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.39-7.40(d, I H), 7.43-7.45(t.1 H), 7.60-7.62(t, l H), 7.78-7.79 (t. l H), 7.90-7.91 (d, I H), 7.93-7.94(d, I H), 7.98-8.00(d, l H), 8.06-8.07(d, I H), 8.44-8.46(d, I H);
(386)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide ' HNMR (DMSO, 400MHz) S: 7.39-7.40(d,1 H), 7.43-7.45(t, l H), 7.60-7.62(t, I
H), 7.78-7.79 (t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 7.98-8.00(d, ] H), 8.06-8.07(d, l H), 8.34-8.35(d, I H), 8.36(s, I H), 8.40-8.42(d, I H), 8.44-8.46(d. I H);
(387)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 6.93-6.95(t, l H), 7.39-7.40(d, I H), 7.43-7.45(t, I
H), 7.60-7.62(t, l H), 7.78-7.79 (t,1 H), 7.89-7.91 (d, ] H), 7.93-7.94(d,1 H), 7.98-8.00(d, l H), 8.06-8.07(d,I H), 8.40-8.43(d, I H), 8.45-8.46(d,2H);

(388)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-2-py ridyl)am ide ' HNMR (DMSO, 400MHz) S: 6.62-6.64(t,1 H), 6.70-6.72(d,1 H), 7.39-7.40(d, I
H), 7.43-7.45(t, I H), 7.55-7.57(t, l H), 7.60-7.62(t, l H), 7.78-7.79 (t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 7.98-8.00(d, I H), 8.04-8.05(d, I H), 8.07-8.09(d, I H), 8.44-8.46(d, l H);
(389)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.39-7.40(d, l H), 7.43-7.45(t, I H), 7.60-7.62(t, I H), 7.78-7.79 (t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 7.98-8.00(d, l H), 8.06-8.07(d, I H), 8.12(s, I H), 8.44-8.46(d, I H);
(390)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 7.39-7.40(d, l H), 7.43-7.45(t, l H), 7.60-7.62(t, I
H), 7.78-7.79 (t, ] H), 7.89-7.91 (d, l H), 7.82(s, I H), 7.93-7.94(d, l H), 7.98-8.00(d, I H), 8.06-8.07(d, I H), 8.33(s, l H), 8.44-8.46(d, I H), 11.53(s, I H);

(391)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s, I H), 7.39-7.40(d,1 H), 7.43-7.45(t, I H), 7.60-7.62(t, I H), 7.78-7.79 (t, l H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 7.98-8.00(d, I H), 8.06-8.07(d, ] H), 8.44-8.46(d,1 H);

(392)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 5.98(s,1 H), 7.39-7.40(d, l H), 7.43-7.45(t, l H), 7.60-7.62(t,1 H), 7.74(s,2H), 7.78-7.79 (t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 7.98-8.00(d, I H), 8.06-8.07(d, I H), 8.44-8.46(d, I H) ;

(393)2-(2-quinolinyl)-1 H-benzi midazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.39-7.40(d, I H), 7.43-7.45(t, l H), 7.60-7.62(t, I
H), 7.78-7.79 (t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 7.98-8.00(d, ] H), 8.06-8.07(d, I H), 8.44-8.46(d, l H), 9.34(s, I H);

(394)2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 6.60-6.61 (d, l H), 6.63-6.65(t,1 H), 6.96-6.98(t, I
H), 6.99-7.01 (d, l H), 7.39-7.40(d, I H), 7.43-7.45(t, I H), 7.60-7.62(t, I H), 7.78-7.79 (t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 7.98-8.00(d, I H), 8.06-8.07(d, I H), 8.44-8.46(d,1 H) ;
(395)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 5 .46-5.48(d, l H), 7.10-7.11 (d, l H), 7.39-7.40(d, I
H), 7.43-7.45(t, l H), 7.60-7.62(t. I H), 7.78-7.79 (t, ] H), 7.82(s, I H), 7.89-7.91(d, I H), 7.93-7.94(d,1 H), 7.98-8.00(d, I H), 8.06-8.07(d, I H), 8.44-8.46(d, I H) ;
(396)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.39-7.40(d, l H), 7.43-7.45(t, l H), 7.60-7.62(t,1 H), 7.78-7.79 (t, I H), 7.86-7.88(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 7.98-8.00(d, I H), 8.06-8.07(d, I H), 8.16-8.18(d,1 H), 8.44-8.46(d, I H);

(397)2-(2-quinolinyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.39-7.40(d,1 H), 7.43-7.45(t, l H), 7.60-7.62(t, I
H), 7.78-7.79 (t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.57-8.59(d, l H), 7.98-8.00(d, l H), 8.06-8.07(d, l H), 8.44-8.46(d, I H), 11 .53(s, l H);

(398)(L)-2-(3-quinolinyl)-1 H-benzimidazole-4-IN-(1-hyd roxymethyl-2-p-nitrophenylh ydroxyethyl))amide 'HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, ] H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3 .65-3.68(t, I H), 3.70-3 .72(d, I H), 4.73-4.77(t, I H), 7.43-7.45(t, I H), 7.59-7.60(t, I H), 7.62-7.65(d,2H), 7.77-7.79(t,I H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 7.98-8.00(d, I H), 8.06-8.08(d,1 H), 8.17-8.20(d,2H), 8.22(s,1 H), 8.57(s, I H) ;

(399)(L)-2-(3-quinolinyl)-1 H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)Jamide 'HNMR (DMSO, 400MHz) S: 3.1 7-3.18(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3.65-3.68(t, I H), 3.70-3.72(d, l H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, l H), 7.60-7.62(t,1 H), 7.77-7.79(t,1 H), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 7.98-8.00(d, l H), 8.06-8.08(d,1 H), 8.22(s, I H), 8.57(s, l H) ;

(400)2-(3-q uinolinyl)-1 H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.36(m,1 H), 2.65-2.66(m, I H), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.77-2.80(m, I H), 3.02-3.05(m,1 H), 3.99-4.01 (m, I H), 7.43-7.45(t, l H), 7.60-7.62(t, l H), 7.89-7.91 (d, ] H), 7.93-7.94(d, l H), 7.98-8.00(d, I H), 8.06-8.08(d, I H), 8.22(s, I H), 8.57(s, I H);

(401)2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-pyrim idinyl)amide ' HNMR (DMSO, 400MHz) S: 6.93-6.95(t, I H), 7.43-7.45(t, I H), 7.60-7.62(t, l H), 7.77-7.79(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 7.98-8.00(d, I H), 8.06-8.08(d, ] H), 8.22(s, I H), 8.45-8.46(d,2H), 8.57(s, I H);

(402)(L)-2-(2-piperidinyl)-1H-benzimidazole-4-IN-(1-hydroxymethyl-2-p-nitrophenylh ydroxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, l H), 1.47-1 .48(m, I H), 1.50-1 .52(m, I H), 1.55-1 .57(m, l H), 1.67-1 .69(m, I H), 1.92-1 .95(m, ] H), 2.69-2.72(m, l H), 2.79-2.81 (m, l H), 3.17-3.1 8(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m, I H), 3.65-3.68(t, l H), 3.70-3.72(d, l H), 4.02-4.05(m, l H), 4.73-4.77(t, I H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 8.17-8.20(d,2H);

(403)(L)-2-(2-piperidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)Jamide 'HNMR (DMSO, 400MHz) 8: 1.43-1.45(m,IH), 1.47-1.48(m,1H), 1.50-1.52(m,IH), 1.55-1 .57(m, ] H), 1.67-1 .69(m, l H), 1.92-1 .95(m, l H), 2.69-2.72(m,1 H), 2.79-2.81 (m, l H), 3.17-3.1 8(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m, l H), 3.65-3.68(t,1 H), 3.70-3.72(d,1 H), 4.02-4.05(m, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d, I H);

(404)2-(2-piperidinyl)-1 H-benzimidazole-4-IN-(1-methyl-2-p-chlorophenylhyd roxyeth yl))amide 'HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.43-I.45(m,IH), 1.47-I.48(m,1H), 1.50-1.52(m,IH), 1.55-1.57(m,IH), 1.67-1.69(m,lH), 1.92-1.95(m,IH), 2.69-2.72(m,IH), 2.79-2.81 (m, I H), 3.25-3.28(m,1 H), 3 .65-3.68(t, l H), 4.02-4.05(m, I H), 4.73-4.77(t, l H), 7.29-7.30(d,2H), 7.40-7.41 (d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(405)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-N'-piperadinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.43-1.45(m,1H), 1.47-1.48(m,IH), 1.50-1.51(m,IH), 1.53-1.55(m,4H), 1.55-1.57(m,IH), 1.59-1.63(m,2H), 1.67-1.69(m,IH), 1.92-1.95(m,IH), 2.69-2.72(m, l H), 2.79-2.81 (m, I H), 3.10-3.15(t,4H), 4.02-4.05(m, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93 -7.94(d, l H) ;

(406)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.43-1.45(m,IH), 1.47-1.48(m,1H), 1.50-1.52(m,IH), 1.55-1.57(m,IH), 1.67-1.69(m,1H), 1.87-1.88(m,IH), 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m, I H), 2.69-2.70(m, l H), 2.72-2.73(m, l H), 2.75-2.76(m, I H), 2.77-2.80(m, I H), 2.82-2.85(m, I H), 3.02-3.05(m, l H), 3.99-4.01 (m, I H), 4.03-4.05(m, l H), 7.43-7.45(t, 1 H), 7.89-7.91(d, I H), 7.93-7.94(d,1 H);

(407)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,IH), 1.47-1.48(m,IH), 1.50-1.52(m,IH), 1.55-1 .57(m, l H), 1.67-1 .69(m, I H), 1.92-1.95(m,I H). 2.69-2.72(m, I H), 2.79-2.81 (m, l H), 4.02-4.05(m, I H), 7.12-7.1 5(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(408)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.47-1.48(m,IH), 1.50-1.52(m,IH), 1.55-1 .57(m, I H), 1.67-1 .69(m, l H), 1.92-1 .95(m, I H), 2.69-2.72(m, l H), 2.79-2.81 (m, l H), 4.02-4.05(m, I H), 6.27(s,2H), 6.38-6.40(d, I H), 6.56-6.58(t, I H), 6.75-6.76(d, l H), 7.02-7.04(t, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(409)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,IH), 1.47-1.48(m,IH), 1.50-1.52(m,IH), 1.55-1 .57(m, I H), 1.67-1 .69(m, l H), 1.92-1 .95(m, I H), 2.69-2.72(m, I H), 2.79-2.81(m,1 H), 4.02-4.05(m, I H), 6.35-6.37(d, l H), 6.93(s, I H), 7.43-7.45(t, I H), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H) ;

(410)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide ' HNMR (DMSO, 400MHz) 6: 1.43-1.45(m, l H), 1.47-1.48(m,1 H), 1.50-1.52(m, I
H), 1.55-I .57(m, l H), 1.67-I .69(m, I H), 1.92-i .95(m, I H), 2.69-2.72(m, l H), 2.79-2.81 (m, l H), 4.02-4.05(m, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.37(s,2H), 9.24-9.26(d, I H), 13.00-13 .03(d, l H);

(411)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,IH), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-I .57(m, l H), 1.67-1 .69(m, l H), 1.92-I .95 (m, I H), 2.69-2.72(m, I
H), 2.79-2.81 (m, l H), 4.02-4.05(m, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.61 (s, I H), 8.63-8.65(d,1 H), 13.71-13.75(d,1 H);

(412)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 5: 1.43-1.45(m,IH), 1.47-1.48(m,IH), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.84-1.89(m,1H), 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.69-2.72(m, I H), 2.79-2.81 (m, I H), 2.84-2.85(m,4H), 4.02-4.05(m, l H), 7.43-7.45(t, I H), 7.90-7.91 (d, I H), 7.93-7.94(d, I H);

(413)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,IH), 1.55-1 .57(m, l H), 1.67-1 .69(m, l H), 1.92-1 .95 (m, I H), 2.69-2.72(m, I
H), 2.79-2.81 (m, I H), 4.02-4.05(m, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.34-8.35(d,1 H), 8.36(s,IH), 8.40-8.42(d,1H);

(414)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1 H), 1.47-1.48(m, I H), 1.50-1.52(m, ]
H), 1.55-1 .57(m, l H), 1.67-1 .69(m, I H), 1.92-1 .95(m, I H), 2.69-2.72(m, I H), 2.79-2.81 (m, l H), 4.02-4.05(m, l H), 6.93-6.95(t,1 H), 7.43-7.45(t, ] H), 7.89-7.91 (d, l H), 7.93-7.94(d, ] H), 8.45-8.46(d,2H);

(41 5)2-(2-piperidinyl)-1 H-benzi midazole-4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 6: 1.43-1.45(m, l H), 1.47-1.48(m, l H), 1.50-1.52(m, l H), 1.55-1.57(m,1 H), 1.67-1.69(m,1 H), 1.92-1 .95(m, l H), 2.69-2.72(m,1 H), 2.79-2.8 1(m, l H), 4.02-4.05(m, ] H), 6.62-6.64(t, l H), 6.70-6.72(d, l H), 7.43-7.45(t, I H), 7.55-7.57(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.07-8.09(d, I H);

(416)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,IH), 1.47-1.48(m,IH), 1.50-1.52(m,1H), 1.55-1 .57(m, I H), 1.67-1 .69(m, l H), 1.92-1 .95(m, l H), 2.45(s,3H), 2.69-2.72(m, l H), 2.79-2.81 (m, I H), 4.02-4.05(m, I H), 7.43-7.45(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.12(s,I H);

(417)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, I H), 1.47-1 .48(m, I H), 1.50-1.52(m,1 H), 1.55-1 .57(m, I H), 1.67-1 .69(m, l H), 1.92-1 .95(m, l H), 2.69-2.72(m, I H), 2.79-2.81(m,1 H), 4.02-4.05(m, I H), 7.43-7.45(t, I H), 7.89-7.9 1(d, l H), 7.82(s,1 H), 7.93-7.94(d, l H), 8.33(s,IH), 11.53(s,IH);

(418)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimid inyl)amide ' HNMR (DMSO, 400MHz) 8: 1.43-1 .45(m, l H), 1.47-1 .48(m, I H), 1.50-I .52(m, I H), 1.55-1.57(m,1 H), 1.67-1.69(m,1 H), 1.92-1.95(m,1 H), 2.69-2.72(m, I H), 2.79-2.81 (m, l H), 3.82(s,6H), 4.02-4.05(m,1 H), 5.71(s,1 H), 7.43-7.45(t,1 H), 7.89-7.91 (d, I
H), 7.93-7.94(d, l H);

(419)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, I H), 1.47-1 .48(m, I H), 1.50-1 .52(m, I H), 1.55-i .57(m, I H), 1.67-1 .69(m, I H), 1.92-1 .95(m, I H), 2.69-2.72(m,1 H), 2.79-2.81(m,1 H), 4.02-4.05(m, I H), 5 .98(s, I H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H);

(420)2-(2-pi peridinyl)-1 H-benzimidazole-4-(N-4,6-d ichloro-5-pyrimidi nyl)a mide ' HNMR (DM SO, 400MHz) S: 1.43-1.45(m, I H), 1.47-1.48(m, l H), 1.50-1.52(m, I
H), 1.55-1 .57(m, I H), 1.67-1 .69(m, I H), 1.92-1.95(m,1 H), 2.69-2.72(m, I H), 2.79-2.81 (m, l H), 4.02-4.05(m, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.34(s, I H) ;
(421)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,IH), 1.47-1.48(m,IH), 1.50-1.52(m,IH), 1.55-1 .57(m, I H), 1.67-I .69(m, I H), 1.92-1.95(m,1 H), 2.69-2.72(m, I H), 2.79-2.8 1(m, I H), 4.02-4.05(m, l H), 6.60-6.61 (d, I H), 6.63-6.65(t, I H), 6.96-6.98(t, I H), 6.99-7.01 (d, I H), 7.43-7.45(t, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, l H);

(422)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 8: 1.43-I .45(m, l H), I .47-1.48(m, I H), 1.50-1 .52(m, I H), 1.55-1 .57(m, I H), 1.67-1 .69(m, l H), 1.92-1 .95(m, l H), 2.69-2.72(m, I H), 2.79-2.81(m,1 H), 4.02-4.05(m, I H), 5.46-5.48(d, I H), 7.10-7.11 (d, ] H), 7.43-7.45(t, l H), 7.82(s, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(423)2-(2-piperidinyl)-1 H-benzimidazole-4-(N-6-purinyl)amide ' HNMR (DMSO, 400MHz) S: 1.43-1.45(m, l H), 1.47-1.48(m, l H), 1.50-1.52(m, I
H), l .55-1.57(m, l H), 1.67-1 .69(m, l H), 1.92-I .95(m, l H), 2.69-2.72(m, I H), 2.79-2.81 (m, I H), 4.02-4.05(m, I H), 7.43-7.45(t, l H), 7.86-7.88(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.16-8.18(d, I H);

(424)2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) S: 1.43-1.45(m,IH), 1.47-1.48(m,1H), 1.50-1.52(m,IH), 1.55-1.57(m,1 H), 1.67-1 .69(m, I H), 1.92-1.95(m,1 H), 2.69-2.72(m,1 H), 2.79-2.81 (m, I H), 4.02 -4.05(m, I H), 7.43-7.45(t,1 H), 7.89 -7.91(d, I H), 7.93 -7.94(d, I H), 8.57 -8.59(d, ] H), 11.53(s,IH);

(425)(L)-2-(3-piperidinyl)-1 H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl h ydroxyethyl)lamide IHNMR (DMSO, 400MHz) 8: 1.43-I.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,IH), 1.92-1 .95(m, I H), 2.71 -2.73(m, I H), 2.74-7.76(m, I H), 2.78-2.80(m,1 H), 2.90-2.92(t, I H), 3.12-3.1 5(t, l H), 3.17-3.1 8(m,1 H), 3.25-3.28(m, l H), 3.50-3.52(m, l H), 3.65-3.68(t, l H), 3.70-3.72(d, l H), 4.73-4.77(t, l H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, I H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(426)(L)-2-(3-piperidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)lamide IHNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.53-1.55(m,IH), 1.67-1.69(m,1H), 1.92-1 .95(m, l H), 2.71 -2.73(m, l H), 2.74-7.76(m, I H), 2.78-2.80(m, I H), 2.90-2.92(t, I H), 3.12-3.1 5(t, I H), 3.17-3.1 8(m, I H), 3.25-3.28(m,1 H), 3.50-3.52(m, I H), 3.65-3.68(t,1 H), 3.70-3.72(d,1H), 4.73-4.77(t,IH), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, l H), 7.89-7.90(d, I H), 7.93-7.95(d, I H);

(427)2-(3-piperidinyl)-1 H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) S: 1.43-1.45(m,IH), 1.53-1.55(m,1H), 1.67-1.69(m,IH), 1.89-1.90(m,2H), 1.92-1.95(m,1 H), 2.62-2.36(m, I H), 2.65-2.66(m,1 H), 2.69-2.70(m, I H), 2.69-2.70(m, I H), 2.71-2.72(m, I H), 2.74-7.76(m, I H), 2.77-2.80(m, I H), 2.82-2.84(m, I H), 2.90-2.92(t, I H), 3.02-3.05(m, l H), 3.15-3. 17(t, l H), 3.99-4.01(m, l H), 7.43-7.45(t, l H), 7.89-7.91(d, I H), 7.93-7.94(d,I H);

(428)2-(3-piperidinyl)-1 H-benzim idazole-4-(N-2-pyrimidinyl)amide IHNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.53-1.55(m,IH), 1.67-1.69(m,IH), 1.92-1 .95(m, ] H), 2.71 -2.73(m, ] H), 2.74-7.76(m, l H), 2.78-2.80(m, I H), 2.90-2.92(t, I H), 3.15-3.1 7(t, I H), 6.93-6.95(t, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.45-8.46(d,2H);

(429)(L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylh ydroxyethyl)lamide 'HNMR (DMSO, 400MHz) 8: 1.67-1.69(m,2H), 1.92-1.95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m, I H), 2.82-2.83(m,2H), 3.17-3.1 8(m, ] H), 3.25-3.28(m, l H), 3.50-3.52(m, I H), 3.65-3 .68(t, I H), 3.70-3 .72(d, l H), 4.73-4.77(t, l H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d,1 H), 7.93-7.95(d, I H), 8.17-8.20(d,2H);

(430)(L)-2-(4-piperidinyl)-1 H-benzimidazole-4-[N-(1-hyd roxymethyl-2-p-aminophenyl hydroxyethyl)Jamide 'HNMR (DMSO, 400MHz) 6: 1.67-1.69(m,2H), 1.92-1.95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m, I H), 2.82-2.83(m,2H), 3.1 7-3.18(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m, I H), 3.65-3 .68(t, I H), 3.70-3.72(d,1 H), 4.73-4.77(t, l H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.1 3(d,2H), 7.43-7.45(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d, I H);

(431) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) S: 1.67-1.69(m,2H), 1.89-1.90(m,2H), 1.92-1.95(m,2H), 2.62-2.36(m, I H), 2.65-2.66(m, I H), 2.67-2.68(m, l H), 2.69-2.71(m,2H), 2.72-2.74(m, l H), 2.75-2.76(m, l H), 2.78-2.80(m, l H), 2.82-2.83(m,2H), 3.02-3.05(m, l H), 3.99-4.01 (m, I H), 7.43-7.45(t, I H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H);

(432) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide '1-1NMR (DMSO, 400MHz) S: 1.67-1.69(m,2H), 1.92-1.95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m,1 H), 2.82-2.83(m,2H), 6.93-6.95(t,1 H), 7.43-7.45(t,1 H), 7.89-7.9 1(d, l H), 7.93-7.94(d,IH), 8.45-8.46(d,2H);

(433)(L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hyd roxymethyl-2-p-nitrophenylhydr oxyethyl)]amide i HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m,1 H), 3.65-3.68(t, l H), 3.70-3.72(d,1 H), 4.73-4.77(t, l H), 7.01 -7.04(t, l H), 7.31 -7.33(t, l H), 7.43-7.45(t, l H), 7.54-7.56(d, l H), 7.62-7.65(d,2H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 8.14-8.1 6(d, l H), 8.17-8.20(d,2H), 8.60-8.62(d, l H);

(434)(L)-2-(3-indolyl)-1 H-benzimidazole-4-[N-(1-hyd roxymethyl-2-p-a minophenylhyd roxyethyl)lamide ' HNMR (DMSO, 400MHz) 6: 3.17-3.18(m, I H), 3.25-3.28(m, l H), 3.50-3.52(m, l H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, l H), 6.27(s,2H), 6.56-6.58(d,2H), 7.01 -7.04(t, l H), 7.11-7.13(d,2H), 7.31 -7.33(t, l H), 7.43-7.45(t, l H), 7.54-7.56(d, l H), 7.89-7.90(d,1 H), 7.93-7.95(d, I H), 8.14-8.16(d,I H), 8.60-8.62(d, I H);

(435)2-(3-indolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) S: 1.12-1.15(d,3H), 3.25-3.28(m,IH), 3.65-3.68(t,1H), 4.73-4.77(t, l H), 7.01 -7.04(t, l H), 7.29-7.30(d,2H), 7.31 -7.33(t, l H), 7.40-7.41(d,2H), 7.43-7.45(t, I H), 7.54-7.56(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.14-8.1 6(d, l H), 8.60-8.62(d, I H);
(436) 2-(3-indolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.01 -7.04(t, l H), 7.31 -7.33(t, l H), 7.43-7.45(t, I H), 7.54-7.56(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.14-8.1 6(d, I H), 8.60-8.62(d, l H);

(437) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide ' HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m, I H), 2.65-2.66(m, I
H), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.77-2.80(m,1 H), 3.02-3.05(m, l H), 3.99-4.01(m, l H), 7.01 -7.04(t, I H), 7.31 -7.33(t, l H), 7.43-7.45(t, l H), 7.54-7.56(d, l H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.14-8.16(d, l H), 8.60-8.62(d, I H);

(438) 2-(3-indolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.01-7.04(t, l H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.31 -7.33(t, I H), 7.43-7.45(t, l H), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.14-8.16(d, I H), 8.60-8.62(d, I H);

(439) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d, I H), 6.56-6.58(t, I H), 6.75-6.76(d. I H), 7.02-7.04(t, I H), 7.06-7.08(t, l H), 7.31 -7.33(t, I H), 7.43-7.45(t,1 H), 7.54-7.56(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.14-8.1 6(d, l H), 8.60-8.62(d, l H) ;
(440) 2-(3-indolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 6.35-6.37(d, l H), 6.93(s, l H), 7.01 -7.04(t, l H), 7.31 -7.33(t, I H), 7.43-7.45(t,1 H), 7.50-7.52(d,1 H), 7.54-7.56(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.14-8.16(d,1 H), 8.60-8.62(d, I H);
(441)2-(3-indolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.01-7.04(t, l H), 7.31-7.33(t, l H), 7.43-7.45(t, l H), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.14-8.1 6(d, I H), 8.60-8.62(d, I H), 8.37(s,2H), 9.24-9.26(d,IH), 13.00-13.03(d,IH);
(442)2-(3-indolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.01 -7.04(t, l H), 7.31 -7.33(t, l H), 7.43-7.45(t, l H), 7.54-7.56(d, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.14-8.1 6(d, l H), 8.57-8.59(d, l H), 8.61 (s, I H), 8.63-8.65(d, I H), 13.71-13.75(d,1H);

(443)2-(3-indolyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.01 -7.04(t, I H), 7.31 -7.33(t, l H), 7.43-7.45(t, I H), 7.54-7.56(d, l H), 7.90-7.91 (d, l H), 7.93-7.94(d, l H), 8.14-8.16(d, I H), 8.60-8.62(d, I H) ;
(444)2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) 8: 7.01-7.04(t, I H), 7.31-7.33(t, I H), 7.43-7.45(t, I
H), 7.54-7.56(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.14-8.1 6(d, l H), 8.34-8.35(d, l H), 8.36(s, I H), 8.40-8.42(d,I H), 8.60-8.62(d, I H) ;

(445)2-(3-indolyl)-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 8: 6.93-6.95(t,IH), 7.01-7.04(t,IH), 7.31-7.33(t,IH), 7.43-7.45(t, l H), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, ] H), 8.14-8.1 6(d, l H), 8.45-8.46(d,2H), 8.60-8.62(d, l H);

(446)2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide ' HNMR (DMSO, 400MHz) 6: 6.62-6.64(t, l H), 6.70-6.72(d, l H), 7.01 -7.04(t, l H), 7.31-7.33(t,IH), 7.43-7.45(t,IH), 7.54-7.56(d,IH), 7.57-7.58(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1 H), 8.07-8.09(d, I H), , 8.14-8.16(d, I H), 8.60-8.62(d, I H);
(447)2-(3-indolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide ' HNMR (DMSO, 400MHz) 8: 2.45(s,3H), 7.01-7.04(t, I H), 7.31-7.33(t, I H), 7.43-7.45(t, I H), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.12(s, I H), 8.14-8.16(d,IH), 8.60-8.62(d,IH);

(448)2-(3-indolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 8: 7.01 -7.04(t, I H), 7.31 -7.33(t, I H), 7.43-7.45(t, I H), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.82(s, l H), 7.93-7.94(d, I H), 8.14-8.16(d, I H), 8.33(s, I H), 8.60-8.62(d, I H), II .53(s,1 H);

(449)2-(3-indolyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s, l H), 7.01-7.04(t, l H), 7.31 -7.33(t, I H), 7.43-7.45(t, I H), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.14-8.16(d, I H), 8.60-8.62(d, I H);

(450)2-(3-indolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 8: 5.98(s,1H), 7.01-7.04(t,IH), 7.31-7.33(t,IH), 7.43-7.45(t, I H), 7.54-7.56(d,1 H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.14-8.16(d,I H), 8.60-8.62(d,I H);

(451)2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.01-7.04(t,IH), 7.31-7.33(t,1H), 7.43-7.45(t,IH), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.14-8.1 6(d, I H), 8.60-8.62(d,1 H), 9.34(s, I H);

(452)2-(3-indolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 6.60-6.61(d, I H), 6.63-6.65(t, I H), 6.96-6.98(t, I
H), 6.99-7.01 (d, l H), 7.02-7.04(t, ]H), 7.31-7.33(t, I H), 7.43-7.45(t, IH), 7.54-7.56(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.14-8.1 6(d, I H), 8.60-8.62(d, I H);
(453)2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 'HNMR (DM SO, 400MHz) 8: 5.46-5.48(d, I H), 7.01-7.04(t, I H), 7.10-7.11(d, l H), 7.31-7.33(t, I H), 7.43-7.45(t, I H), 7.54-7.56(d, I H), 7.82(s, I H), 7.89-7.91(d, l H), 7.93-7.94(d, I H), 8.14-8.16(d, I H), 8.60-8.62(d, I H);
(454)2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.01-7.04(t,IH), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d, l H), 7.86-7.88(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.13-8.1 5 (d,1 H), 8.17-8.1 9(d, I H), 8.60-8.62(d, l H) ;

(455)2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.01-7.04(t,IH), 7.31-7.33(t,1H), 7.43-7.45(t,IH), 7.54-7.56(d, l H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.14-8.1 6(d, I H), 8.57-8.59(d,1 H), 8.60-8.62(d,IH), 11.53(s,1H);

(456)(L)-2-(2'-imidazolyl)-l H-benzimidazole-4-[N-(1-hyd roxymethyl-2-p-nitrophenylhyd ro xyethyl)]amide ' HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m, l H), 3.65-3.68(t,1 H), 3.70-3.72(d,1 H), 4.73-4.77(t,1 H), 7.00-7.01(d, I H), 7.02-7.04(t, I H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, l H), 8.17-8.20(d,2H), 13.00-13.03(d,1 H);

(457)(L)-2-(2'-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide ' HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, I H), 3.25-3.28(m, l H), 3.50-3.52(m, I
H), 3.65-3.68(t, l H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.00-7.01 (d, l H), 7.02-7.04(t, l H), 7.11-7.13 (d,2H), 7.43-7.45(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d,I H), 13.00-13.03(d,IH);

(458)2-(2'-imidazolyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]a mide 'HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 3.25-3.28(m, l H), 3.65-3.68(t, l H), 4.73-4.77(t, l H), 7.00-7.01 (d, I H), 7.02-7.04(t, I H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 13.00-13.03(d, l H);

(459)2-(2'-imidazolyl)-l H-benzim idazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.00-7.01 (d, l H), 7.02-7.04(t, I H), 7.43-7.45(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 13.00-13.03(d,1 H);

(460)2-(2-imidazolyl)-1 H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m,1 H), 2.72-2.74(m, l H), 2.77-2.80(m, l H), 3.02-3.05(m,1 H), 3.99-4.01 (m, l H), 7.00-7.0 1(d, l H), 7.02-7.04(t, I H). 7.43-7.45(t, l H), 7.89-7.9 1(d, I H), 7.93-7.94(d, I H), 13.00-13.03(d, I H);

(461)2-(2-imidazolyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 13.00-13.03(d, I H);
(462)2-(2-imidazolyl)-I H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1 H), 7.00-7.01 (d, I H), 7.02-7.04(t, I H), 7.05-7.08(t, l H), 7.43-7.45(t, I H), 7.89-7.91(d,I H), 7.93-7.94(d,1 H), 13.00-1 3.03 (d,1 H) ;

(463)2-(2-imidazolyl)-1 H-benzim idazole-4-(N-5-benzimidazolonyl)amide ' HNMR (DM SO, 400MHz) 6: 6.35-6.37(d, I H), 6.93(s, I H), 7.00-7.01(d, I H), 7.02-7.04(t, I H). 7.43-7.45(t, I H), 7.54-7.56(d,1 H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 13.00-13.03(d, I H);

(464)2-(2-imidazolyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.00-7.01(d,IH), 7.02-7.04(t,IH), 7.43-7.45(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.37(s,2H), 9.24-9.26(d, l H), 13.00-1 3.03(d, I H), 13.05-13.07(d, l H);

(465)2-(2-imidazolyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide ' HNMR (DMSO, 400MHz) 6: 7.00-7.01(d, i H), 7.02-7.04(t, I H), 7.43-7.45(t, I
H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.61 (s, l H), 8.63-8.65(d, I H), 13.00-13.03(d,1 H), 13.71-13.75(d,I H);

(466)2-(2-imidazolyi)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.00-7.01 (d, I H), 7.02-7.04(t, l H), 7.43-7.45(t, I H), 7.90-7.91(d,1 H), 7.93-7.94(d, I H), 13.00-13.03(d, I H);

(467)2-(2-imidazolyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide ' HNMR (DMSO, 400MHz) 6: 7.00-7.01 (d, I H), 7.02-7.04(t, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.34-8.35(d, I H), 8.36(s, I H), 8.40-8.42(d, I H), 13.00-13.03(d, I H);

(468)2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 6.93-6.95(t, I H), 7.00-7.01(d,1 H), 7.02-7.04(1,]H), 7.43-7.45(t, I H), 7.89-7.91 (d, ] H), 7.93-7.94(d, I H), 8.45-8.46(d,2H), 13.00-13 .03(d, I H);
(469)2-(2-imidazolyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide 'HNMR (DM SO, 400MHz) 6: 6.62-6.64(t, I H), 6.70-6.72(d, l H), 7.00-7.01(d, I
H), 7.02-7.04(t, l H), 7.43-7.45(t,1 H), 7.55-7.57(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.07-8.09(d, I H), 13.00-13.03(d, I H);

(470)2-(2-imidazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide ' HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.00-7.01(d, l H), 7.02-7.04(t, I H), 7.43-7.45(t,1H), 7.89-7.91(d,]H), 7.93-7.94(d,lH), 8.12(s,1H), 13.00-13.03(d,IH);
(471)2-(2-imidazolyl)-1 H-benzim idazole-4-(N-2,4-dihyd roxyl-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.00-7.01 (d, l H), 7.02-7.04(t, I H), 7.43-7.45(t,1 H), 7.89-7.91(d,IH), 7.82(s,IH), 7.93-7.94(d,IH), 8.33(s,IH), 11.53(s,]H), 13.00-13.03(d,IH);
(472)2-(2-imidazolyl)-1 H-benzim idazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s, I H), 7.00-7.01(d, l H), 7.02-7.04(t, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 13.00-1 3.03(d, ] H);
(473)2-(2-imidazolyl)-1 H-benzim idazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 5 .98(s, I H), 7.00-7.01(d,1 H), 7.02-7.04(t,I H), 7.43-7.45(t, l H), 7.74(s,2H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 13.00-13.03(d, ] H);
(474)2-(2-imidazolyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 7.00-7.01(d,1 H), 7.02-7.04(t, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 9.34(s, I H), 13.00-13.03(d, I H);

(475)2-(2-imidazolyl)-1 H-benzim idazole-4-(N-o-fluorophenyl)amide ' HNMR (DMSO, 400MHz) 6: 6.60-6.61(d, I H), 6.63-6.65(t, I H), 6.95-6.96(t, ]
H), 6.97-6.99(d, I H), 7.00-7.01 (d, I H), 7.02-7.04(t, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d,1H), 13.00-13.03(d,IH);

(476)2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 5.46-5.48(d, I H), 7.00-7.01(d, l H), 7.02-7.04(t, l H), 7.10-7.11 (d, I H), 7.43-7.45(t, l H), 7.82(s, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 13.00-13.03(d, I H) ;
(477)2-(2-imidazolyl)-1 H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 8: 7.00-7.01(d, l H), 7.02-7.04(t, I H), 7.43-7.45(t, l H), 7.86-7.88(d, I H), 7.89-7.91(d.I H), 7.93-7.94(d, I H), 8.16-8.18(d, I H), 13.00-13.03(d, I H) ;
(478)2-(2-imidazolyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-pu rinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.00-7.01 (d, l H), 7.02-7.04(t, I H), 7.43-7.45(t, l H), 7.89-7.91(d, l H), 7.93 -7.94(d. l H), 8.57-8.59(d,1 H), 11.53(s,1 H), 13.00-1 3.03(d, l H);
(479)(L)-2-(3-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide 'HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m, l H), 3 .65-3.68(t, l H), 3 .70-3.72(d, l H), 4.73-4.77(t, l H), 6.48-6.50(d, l H), 7.43-7.45(t, I H), 7.62-7.65(d,2H), 7.85-7.87(t, l H), 7.89-7.90(d, I H), 7.93-7.95(d, l H), 8.17-8.20(d,2H), 12.62-12.64(d, I H);

(480)(L)-2-(3-pyrazolyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)[amide ' HNMR (DMSO, 400MHz) 6: 3.17-3.18(m,I H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.48-6.50(d,1 H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, l H), 7.85-7.87(t, l H). 7.89-7.90(d, I H), 7.93-7.95(d,1 H), 12.62-12.64(d,1 H);

(481)2-(3-pyrazolyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)Jamide 'HNMR (DMSO, 400MHz) 8: 1.12-1.15(d,3H), 3.25-3.28(m, I H), 3.65-3.68(t, I H), 4.73-4.77(1,1 H), 6.48-6.50(d, I H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, I H), 7.85-7.87(t, I H), 7.89-7.9 1(d, l H), 7.93-7.94(d, l H), 12.62-1 2.64(d, l H) ;

(482)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 6.48-6.50(d, l H), 7.43-7.45(t,1 H), 7.85-7.87(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 12.62-12.64(d, I H);

(483)2-(3-pyrazolyl)-1 H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,IH), 2.69-2.70(m, l H), 2.72-2.74(m, I H), 2.77-2.80(m,1 H), 3.02-3.05(m,1 H), 3.99-4.01 (m, I H), 6.48-6.50(d, l H), 7.43-7.45(t, l H), 7.85-7.87(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 12.62-12.64(d, I H);

(484)2-(3-pyrazolyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)am ide 'HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.85-7.87(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 12.62-12.64(d,1 H);
(485)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-o-aminophenyt)amide 'HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d, l H), 6.48-6.50(d, l H), 6.56-6.58(t,1 H), 6.75-6.76(d, I H), 7.02-7.04(t, l H), 7.43-7.45(t, l H), 7.85-7.87(t, l H), 7.89-7.91(d, I H), 7.93-7.94(d, l H), 12.62-12.64(d, I H);
(486)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)am ide 'HNMR (DMSO, 400MHz) 6: 6.35-6.37(d, I H), 6.48-6.50(d, I H), 6.93(s, I H), 7.43-7.45 (t, I H), 7.54-7.56(d, I H), 7.85-7.87(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 12.62-12.64(d,I H) ;

(487)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 6.48-6.50(d, l H), 7.43-7.45(t, l H), 7.85-7.87(t, I
H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.37(s,2H), 9.24-9.26(d,1 H), 12.62-1 2.64(d, I H), 13.00-13.03(d, I H);

(488)2-(3-pyrazolyl)-1 H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 6.48-6.50(d, I H), 7.43-7.45(t, l H), 7.85-7.87(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.61 (s, I H), 8.63-8.65(d, I H), 12.62-12.64(d, I H), 13.71-13.75(d,I H);

(489)2-(3-pyrazolyl)-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.48-6.50(d, I H), 7.43-7.45(t, l H), 7.85-7.87(t, l H), 7.90-7.91 (d, I H), 7.93-7.94(d, I H), 12.62-12.64(d,1 H);

(490)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide ' HNMR (DMSO, 400MHz) S: 6.48-6.50(d, l H), 7.43-7.45(t, l H), 7.85-7.87(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.34-8.35(d,1 H), 8.36(s, I H), 8.40-8.42(d, l H), 12.62-12.64(d, I H);

(491)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 6.48-6.50(d, I H), 6.93-6.95 (t, I H), 7.43-7.45(t, l H), 7.85-7.87(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.45-8.46(d,2H), 12.62-12.64(d, I H);
(492)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide ' HNMR (DMSO, 400MHz) 6: 6.48-6.50(d, I H), 6.62-6.64(t, l H), 6.70-6.72(d, l H), 7.43-7.45(t, l H), 7.55-7.57(t, l H), 7. 85-7.87(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.07-8.09(d,IH), 12.62-12.64(d,IH);
(493)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.48-6.50(d,IH), 7.43-7.45(t,1H), 7.85-7.87(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.12(s, I H), 12.62-12.64(d, I H);
(494)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 6.48-6.50(d, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.82(s,IH), 7.85-7.87(t,IH), 7.93-7.94(d,IH), 8.33(s,1H), 11.53(s,IH), 12.62-12.64(d,IH);
(495)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s, I H), 6.48-6.50(d, I H), 7.43-7.45(t,1 H), 7.85-7.87(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 12.62-1 2.64(d, I H) ;
(496)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 5.98(s, I H), 6.48-6.50(d, I H), 7.43-7.45 (t, I H), 7.74(s,2H), 7.85-7.87(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 12.62-12.64(d, I H) ;
(497)2-(3-pyrazolyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,IH), 7.43-7.45(t,IH), 7.85-7.87(t,1H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.34(s, I H), 12.62-12.64(d, I H);

(498)2-(3-pyrazolyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide ' HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1 H), 6.60-6.61(d, l H), 6.63-6.65(t, I
H), 6.96-6.98(t, I H), 6.99-7.01 (d, l H), 7.43-7.45(t, l H). 7.85-7.87(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 12.62-1 2.64(d, I H);

(499)2-(3-pyrazolyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 5.46-5.48(d, I H), 6.48-6.50(d, l H), 7.10-7.11 (d, I
H), 7.43-7.45(t, l H), 7.82(s, I H), 7.85-7.87(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 12.62-12.64(d,I H);

(500)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-6-pu rinyl)amide 'HNMR (DMSO, 400MHz) 6: 6.48-6.50(d, l H), 7.43-7.45(t, I H), 7.86-7.88(d, I
H), 7.85-7.87(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.16-8.1 8(d, I H), 12.62-12.64(d, I H) ;
(501)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,IH), 7.43-7.45(t,IH), 7.85-7.87(t,IH), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.57-8.59(d, l H), 11 .53(s, l H), I
2.62-12.64(d, I H);
(502)(L)-2-(2-pyrimidinyl)-1 H-benzimidazole-4-IN-(I-hydroxymethyl-2-p-nitrophenylhyd r oxyethyl))amide 'HNMR (DMSO, 400MHz) 6: 3.17-3.18(m,IH), 3.25-3.28(m,IH), 3.50-3.52(m,IH), 3.65-3 .68(t, l H), 3.70-3.72(d, l H), 4.73-4.77(t, I H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.67-7.70(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d, l H), 8.17-8.20(d,2H), 9.08-9.11 (d,2H);
(503)(L)-2-(2-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide ' HNMR (DMSO, 400MHz) 8: 3.1 7-3.18(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3 .65-3.68(t, l H), 3.70-3.72(d, I H), 4.73-4.77(t, l H), 6.27(s,2H), 6.56-6.58(d,2H), 7.67-7.70(t,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.08-9.11(d,2H);

(504)2-(2-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhyd roxyeth yl)]amide 'HNMR (DMSO, 400MHz) 8: 1.12-1.15(d,3H), 3.25-3.28(m,IH), 3.65-3.68(t,IH), 4.73-4.77(t, l H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, l H), 7.67-7.70(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.08-9.11(d,2H);

(505)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t, l H), 7.67-7.70(t, l H), 7.89-7.91(d, I H), 7.93-7.94(d, l H), 9.08-9.11(d,2H);
(506)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m,1H), 2.69-2.70(m, l H), 2.72-2.74(m, l H), 2.77-2.80(m.1 H), 3.02-3.05(m, I H), 3.99-4.01(m, l H), 7.43-7.45(t,1 H), 7.67-7.70(t. I H), 7.89-7.91 (d,1 H), 7.93-7.94(d, l H), 9.08-9.11 (d,2H);
(507)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,IH), 7.67-7.70(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.08-9.11 (d,2H);
(508)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d, l H), 6.56-6.58(t, l H), 6.75-6.76(d, l H), 7.02-7.04(t, l H), 7.43-7.45(t, l H), 7.67-7.70(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 9.08-9.11(d,2H);

(509)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide I HNMR (DMSO, 400MHz) 6: 6.35-6.37(d, i H), 6.93(s,1 H), 7.43-7.45(t, I H), 7.54-7.56(d, I H), 7.67-7.70(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.08-9.11 (d,2H);
(510)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide ' HNMR (DMSO, 400MHz) 8: 7.43-7.45(t, l H), 7.67-7.70(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.37(s,2H), 9.08-9.11(d,2H), 9.24-9.26(d, I H), 13.00-13.03(d, I H);
(511)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 8: 7.43-7.45 (t,1 rl), 7.67-7.70(t, l H), 7.89-7.91(d, I
H), 7.93-7.94(d,I H), 8.61 (s, I H), 8.63-8.65(d, I H), 9.08-9.11 (d,2H), 13.71-13.75(d, I H) ;
(512)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t, I H), 7.67-7.70(t, l H), 7.90-7.91 (d, I H), 7.93-7.94(d, l H), 9.08-9.11 (d,2H);
(513)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-2-pyrazinyl)amide ' HNMR (DM SO, 400MHz) 6: 7.43-7.45(t, I H), 7.67-7.70(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d,1 H), 8.34-8.35(d, I H), 8.36(s, I H), 8.40-8.42(d, I H), 9.08-9.11 (d,2H);
(514)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 8: 6.93-6.95(t, I H), 7.43-7.45(t, l H), 7.67-7.70(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.45-8.46(d,2H), 9.08-9.11 (d,2H);
(515)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-2-pyridyl)amide ' HNMR (DMSO, 400MHz) 6: 6.62-6.64(t, I H), 6.70-6.72(d, I H), 7.43-7.45(t, l H), 7.55-7.57(t, l H), 7.67-7.70(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.07-8.09(d, l H), 9.08-9.11(d,2H);

(516)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.43-7.45(t, I H), 7.67-7.70(t, l H), 7.89-7.91(d,I H), 7.93-7.94(d, I H), 8.12(s,IH). 9.08-9.11 (d,2H);

(517)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-2,4-dihyd roxyl-5-pyrimidinyl)amide ' HNMR (DM SO, 400MHz) 6: 7.43-7.45(t, l H), 7.67-7.70(t, I H), 7.89-7.91 (d, I H), 7.82(s,IH), 7.93-7.94(d,IH), 8.33(s,lH), 9.08-9.11(d,2H), 11.53(s,1H);
(518)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s, I H), 7.67-7.70(t, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.08-9.11 (d,2H);

(519) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 5.98(s, I H), 7.43-7.45(t, l H), 7.67-7.70(t, I H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.08-9.11 (d,2H);

(520)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, 1 H), 7.67-7.70(t, l H), 7.89-7.91 (d, I
H), 7.93-7.94(d, I H), 9.08-9.11 (d,2H), 9.34(s, I H);

(521)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) S: 6.60-6.61(d, l H), 6.63-6.65(t, l H), 6.96-6.98(t, l H), 6.99-7.01 (d, l H), 7.43-7.45(t, I H), 7.67-7.70(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.08-9.11 (d,2H);

(522)2-(2-pyrimidinyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,IH), 7.10-7.11(d,IH), 7.43-7.45(t,IH), 7.67-7.70(t, l H), 7.82(s, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.08-9.11 (d,2H);
(523)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, I H), 7.67-7.70(t, I H), 7.86-7.88(d, l H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H), 8.16-8.18(d, I H), 9.08-9.11 (d,2H);
(524)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, l H), 7.67-7.70(t, l H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.57-8.59(d,1 H), 9.08-9.11(d,2H), II .53(s, I H);
(525)(L)-2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitroph enylhydroxyethyl)]amide ' HNMR (DMSO, 400MHz) S: 3.17-3.1 8(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m, l H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, l H), 7.38-7.41 (t, l H), 7.43-7.45(t, I H), 7.51-7.53(t,2H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 8.17-8.20(d,2H), 8.28-8.3 1 (d,2H), 9.26(s,2H);

(526)(L)-2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminop henylhydroxyethyl)]amide ' HNMR (DMSO, 400MHz) 6: 3.17-3.1 8(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3.65-3 .68(t, l H), 3.70-3.72(d, I H), 4.73-4.77(t, l H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.38-7.41 (t, I H), 7.43-7.45(t, l H), 7.51-7.53(t,2H), 7.89-7.90(d, I H), 7.93-7.95(d,IH), 8.28-8.31(d,2H), 9.26(s,2H);

(527)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydro xyethyl)Jamide 'HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,IH), 4.73-4.77(t, l H), 7.29-7.30(d,2H), 7.3 8-7.39(t, I H), 7.40-7.41(d,2H), 7.43-7.45(t, l H), 7.51-7.53(t,2H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H), 8.28-8.3 1 (d,2H), 9.26(s,2H);

(528)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.3 8-7.41(t, I H), 7.43-7.45(t, l H), 7.51-7.53(t,2H), 7.89-7.9 1(d, l H), 7.93-7.94(d, l H), 8.28-8.31(d,2H), 9.26(s,2H) ;
(529)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide ' HNMR (DMSO, 400MHz) S: 1.91-1.93(m,2H), 2.62-2.63(m, l H), 2.65-2.66(m, I
H), 2.69-2.70(m, l H), 2.72-2.74(m,1 H), 2.77-2.80(m, l H), 3.02-3.05(m, l H), 3.99-4.01(m,I H), 7.38-7.4 1(t, l H), 7.43-7.45(t, l H), 7.51-7.53(t,2H), 7.89-7.91(d,I H), 7.93-7.94(d, l H), 8.28-8.3 1 (d,2H), 9.26(s,2H);

(530)2-(2-phenyl-5-pyrim idinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.38-7.41 (t, I H), 7.43-7.45(t, I H), 7.51-7.53(t,2H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.28-8.31(d,2H), 9.26(s,2H);

(531)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide ' HNMR (DMSO, 400MHz) S: 6.27(s,2H), 6.38-6.40(d, I H), 6.56-6.5 8(t, I H), 6.75-6.76(d,I H), 7.02-7.04(t,1 H), 7.3 8-7.41(t, ] H), 7.43-7.45(t,I H), 7.51-7.53 (t,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.28-8.31(d,2H), 9.26(s,2H):
(532)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 6.35-6.37(d, I H), 6.93(s, l H), 7.3 8-7.41(t, I H), 7.43-7.45(t,1 H), 7.51-7.53(t,2H), 7.54-7.56(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, ] H), 8.28-8.3 1 (d,2H), 9.26(s,2H);

(533)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.38-7.41(t,1H), 7.43-7.45(t,IH), 7.51-7.53(t,2H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.28-8.3 1 (d,2H), 8.37(s,2H), 9.24-9.26(d, l H), 9.29(s,2H)13.00-13.03(d, I H);

(534)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 8: 7.38-7.41(t,IH), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d, l H), 7.93-7.94(d, I H), 8.28-8.3 1 (d,2H), 8.61 (s, I H), 8.63-8.65(d, l H), 9.26(s,2H), 13.71-13.75(d,IH);

(535)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) S: 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.38-7.41 (t, l H), 7.43-7.45(t, I H), 7.51-7.53(t,2H), 7.90-7.91 (d, I H), 7.93-7.94(d,1 H), 8.28-8.3 1 (d,2H), 9.26(s,2H);

(536)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide ' HNMR (DMSO, 400MHz) 6: 7.38-7.41(t, l H), 7.43-7.45(t,1 H), 7.51-7.53(t,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.28-8.3 1 (d,2H), 8.34-8.35(d, I H), 8.36(s, I H), 8.40-8.42(d, l H), 9.26(s,2H);
(537)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) & 6.93-6.95(t,IH), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.28-8.31(d,2H), 8.45-8.46(d,2H), 9.26(s,2H);

(538)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 6: 6.62-6.64(t, I H), 6.70-6.72(d, I H), 7.38-7.41 (t, I
H), 7.43-7.45(t, I H), 7.51-7.53(t,2H), 7.55-7.57(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.07-8.09(d, I H), 8.28-8.3 1 (d,2H), 9.26(s,2H);
(539)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 8: 2.45(s,3H), 7.38-7.41(t, l H), 7.43-7.45(t, I H), 7.51-7.53(t,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.12(s, I H), 8.28-8.31(d,2H), 9.26(s,2H);

(540)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide i HNMR (DMSO, 400MHz) 6: 7.38-7.41(t, l H), 7.43-7.45(t, l H), 7.51-7.53(t,2H), 7.89-7.91 (d, l H), 7.82(s, l H), 7.93-7.94(d, l H), 8.28-8.31(d,2H), 8.33(s, l H), 9.26(s,2H), I1.53(s,IH);

(541)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,I H), 7.38-7.41 (t, I H), 7.43-7.45(t, l H), 7.51-7.53(t,2H), 7.89-7.91(d,1 H), 7.93-7.94(d, l H), 8.28-8.31(d,2H), 9.26(s,2H);

(542)2-(2-phenyl-5-pyrimidinyl}1H-benzimidazole 4-(N-4-chloro-6-amino-2-pyrimidinyl)amide ' HNMR (DMSO, 400MHz) 6: 5.98(s, l H), 7.38-7.41(t, l H), 7.43-7.45(t, I H), 7.51-7.53(t,2H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.28-8.31(d,2H), 9.26(s,2H);

(543)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 8: 7.38-7.41(t,IH), 7.43-7.45(t,IH), 7.51-7.53(t,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.28-8.3 1 (d,2H), 9.26(s,2H), 9.34(s, I H);
(544)2-(2-phenyl-5-pyrimidinyl}1H-benzimidazole-4 (N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 6.60-6.61 (d, I H), 6.63-6.65(t, l H), 6.96-6.98(t,1 H), 6.99-7.01 (d, I H), 7.38-7.41(t, I H), 7.43-7.45(t,1 H), 7.51-7.53(t,2H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.28-8.3 1 (d,2H), 9.26(s,2H);
(545)2-(2-phenyl-5-pyrimidinyl}1H-benzimidazole-4-(N-2-hydroxyl-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 5.46-5 .48(d, I H), 7.10-7.11 (d, I H), 7.38-7.41 (t, I H), 7.43-7.45(t,1 H), 7.51-7.53(t,2H), 7.82(s, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.28-8.31(d,2H), 9.26(s,2H);

(546)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 7.38-7.41(t,IH), 7.43-7.45(t,IH), 7.51-7.53(t,2H), 7.86-7.88(d,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d,1 H), 8.16-8.1 8(d, I H), 8.28-8.31(d,2H), 9.26(s,2H);

(547)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-0{N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) b: 7.38-7.41(t,IH), 7.43-7.45(t,IH), 7.51-7.53(t,2H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.28-8.31(d,2H), 8.57-8.59(d, I H), 9.26(s,2H), 11.53(s,1H);

(548)(L)-2-(4-amino-6rchloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitro phenylhydroxyethyl)]amide ' HNMR (DMSO, 400MHz) S: 3.17-3.18(m, l H), 3.25-3.28(m, I H), 3.50-3.52(m, l H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 7.43-7.45(t, I H), 7.62-7.65(d,2H), 7.74(s,2H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 8.17-8.20(d,2H), 8.59(s, l H);

(549)(L)-2-(4-amino-6-chloro-5-pyrimidinyl)-IH-benzimidazole--0-[N-(1-hydroxymethyl-2-p-ami nophenylhydroxyethyl)]amide ' HNMR (DMSO, 400MHz) 6: 3.17-3.18(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m, l H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 8.59(s, I H);

(550)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhyd roxyethyn]amide 'HNMR (DMSO, 400MHz) S: 1.12-1.15(d,3H), 3.25-3.28(m,IH), 3.65-3.68(t,1H), 4.73-4.77(t,IH), 7.29-7.30(d,2H), 7.40-7.4 1 (d,2H), 7.43-7.45(t,IH), 7.74(s,2H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H), 8.59(s, I H);

(551)2-(4-amino-b-chioro-5-pyrimidinyl}1H-benzimidazole- -(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.59(s, I H);
(552)2-(4-amino-6-chloro-5-pyrimidinyl}1H-benzimidazole-4(N-2-piperazinyl)amide ' HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m, I H), 2.65-2.66(m, I
H), 2.69-2.70(m, I H), 2.72-2.74(m,1 H), 2.77-2.80(m, l H), 3.02-3.05(m,1 H), 3.99-4.01 (m, l H), 7.43-7.45(t,I H), 7.74(s,2H), 7.89-7.91(d,I H), 7.93-7.94(d, I H), 8.59(s, I
H) ;
(553)2{4-amino-6-chbro-5-pyrimidinyl lH-benzimidazole- -{N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 8: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, l H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.59(s, l H) ;

(554)2-(4-amino-6-chlor -5-pyrimidiny¾1H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,IH), 6.56-6.58(t,IH), 6.75-6.76(d, I H), 7.02-7.04(t, l H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.59(s, I H);

(555)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazobnyl)amide 'HNMR (DMSO, 400MHz) 8: 6.35-6.37(d,IH), 6.93(s,IH), 7.43-7.45(t,IH), 7.54-7.56(d, l H), 7.74(s,2H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.59(s,1 H) ;

(556 )2-(4-amino-6-c h l o ro-5-pyrimidinyl)-1 H-be nzi m i d azol e-4-(N-4' -ca r bo n a m i d o-5' -i midazolyl)amide i HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,IH), 7.74(s,2H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 8.37(s,2H), 8.59(s, l H), 9.24-9.26(d,1 H), 13.00-1 3.03(d, l H);
(557)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1 H), 7.74(s,2H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.59(s, I H), 8.61 (s,IH), 8.63-8.65(d, I H), 13.71-13.75(d,1H);
(558)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 8: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t, l H), 7.74(s,2H), 7.90-7.91 (d, l H), 7.93-7.94(d, I H), 8.59(s, l H);
(559)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N 2-pyrazoyl)amide 'HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, l H), 7.74(s,2H), 7.89-7.91(d, l H), 7.93-7.94(d, I H), 8.34-8.35(d, I H), 8.36(s, l H), 8.40-8.42(d, l H), 8.59(s, l H) ;
(560)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,IH), 7.43-7.45(t,IH), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.45-8.46(d,2H), 8.59(s, I H);
(561)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide ' HNMR (DMSO, 400MHz) 8: 6.62-6.64(t, I H), 6.70-6.72(d, l H), 7.43-7.45(t, l H), 7.55-7.57(t, l H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.07-8.09(d, I H), 8.59(s,1 H);

(562)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.43-7.45(t,IH), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.12(s,1 H), 8.59(s, I H) ;
(563)2{4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)a mide 'HNMR (DMSO, 400MHz) 8: 7.43-7.45(t,IH), 7.74(s,2H), 7.89-7.91(d,IH), 7.82(s,IH), 7.93-7.94(d,1H), 8.33(s,1H), 8.59(s,1H), 11.53(s,IH);
(564)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)a mide 'HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,IH), 7.93-7.94(d,IH), 8.59(s,IH);

(565)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidiny 1)amide 'HNMR (DMSO, 400MHz) 6: 5.98(s,1 H), 7.43-7.45(t, I H), 7.74(s,4H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.59(s, l H);

(566)2-(4-amino-6rchloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinynamide 'HNMR (DMSO, 400MHz) 8: 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,IH), 7.93-7.94(d, l H), 8.59(s, I H), 9.34(s, I H);

(567)2-(4-amino-6-chloro-5-pyrimidinyl)-l H-benzimidazole-4-(N-o-fluorophenyl)am ide ' HNMR (DMSO, 400MHz) 6: 6.60-6.61(d, I H), 6.63-6.65(t,1 H), 6.96-6.98(t, l H), 6.99-7.01 (d, l H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.59(s, l H);

(568)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidin yl)amide 'HNMR (DMSO, 400M14z) 6: 5.46-5 .48(d, l H), 7.10-7.11 (d, I H), 7.43-7.45(t, I H), 7.74(s,2H), 7.82(s, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.59(s, l H);
(569)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzi midazole-4-(N-6-pu rinyl)amide 'HNMR (DMSO, 400MHz) 8: 7.43-7.45(t, I H), 7.74(s,2H), 7.86-7.88(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.16-8.1 8(d, I H), 8.59(s,1 H);
(570)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)a mide ' HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, l H), 7.74(s,2H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 8.57-8.59(d, I H), 8.62(s, l H), 11 .53(s, l H);
(571)(L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-(1-hydroxymethyl-2 -p-nitrophenylhydroxyethyl)lamide 'HNMR (DMSO, 400MHz) S: 1.92-1.95(m,4H), 3.17-3.1 8(m, I H), 3.25-3.28(m, l H), 3.44-3.48(t,4H), 3.50-3.52(m,1 H), 3.65-3 .68(t, I H), 3.70-3.72(d,1 H), 4.73-4.77(t,1 H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 8.17-8.20(d,2H), 9.02(s,2H);

(572)(L)-2-(2-pyrrolidine-l -yl-5-pyrimidinyl)-lH-benzimidazole-4-[N-(1-hydroxymethyl-2 -p-aminophenylhydroxyethyl)lamide 'HNMR (DMSO, 400MHz) S: 1.92-1.95 (m,4H), 3.17-3.1 8(m, l H), 3.25-3 .28(m, I
H), 3.44-3.48(t,4H), 3.50-3.52(m, l H), 3.65-3.68(t, l H), 3.70-3.72(d, l H), 4.73-4.77(t, l H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, I H), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 9.02(s,2H);

(573)2-(2-pyrrolidine-l-yl-5-pyrimidinyl)-lH-benzimidazole-4-[N-(1-methyl-2-p-chloroph enylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) S: 1.12-1.15(d,3H), 1.92-1.95(m,4H), 3.25-3.28(m,IH), 3.44-3.48(t,4H), 3.65-3.68(t,1 H), 4.73-4.77(t, I H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.02(s,2H);

(574)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyi)amide 'HNMR (DMSO, 400MHz) S: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.92-1.95(m,4H), 3.10-3.15(t,4H), 3.44-3.48(t,4H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.02(s,2H);

(575)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO, 400MHz) S: 1.87-1.89(m,2H), 1.92-1.95(m,4H), 2.62-2.63(m,IH), 2.65-2.66(m, I H), 2.69-2.70(m, l H), 2.72-2.74(m, l H), 2.77-2.80(m,1 H), 3.02-3.05(m, l H), 3.44-3.48(t,4H), 3.99-4.01 (m, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.02(s,2H);

(576)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'I-1NMR (DMSO, 400MHz) S: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.02(s,2H);

(577)2-(2-pyrrolidine-l- yi-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.27(s,2H), 6.38-6.40(d, l H), 6.56-6.58(t, l H), 6.75-6.76(d, l H), 7.02-7.04(t, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.02(s,2H);
(578)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl) amide 'HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.35-6.37(d,IH), 6.93(s, l H), 7.43-7.45(t, l H), 7.54-7.56(d, I H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H), 9.02(s,2H);

(579)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imida zolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d, l H), 13.00-13.03(d,IH);

(580)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazoiyl)amide 'HNMR (DMSO, 400MHz) S: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,IH), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.61 (s, I H), 8.63-8.65(d, I H), 9.02(s,2H), 13.71-13.75(d,IH);

(581)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.87-1.89(m,IH), 1.92-1.95(m,4H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t, I H), 7.90-7.91 (d, l H), 7.93-7.94(d, I H), 9.02(s,2H);

(582)2-(2-pyrrolidine-l- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) S: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,IH), 7.89-7.91 (d,1 H), 7.93-7.94(d, l H), 8.34-8.35(d, I H), 8.36(s, I H), 8.40-8.42(d, l H), 9.02(s,2H);

(583)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.45-8.46(d,2H), 9.02(s,2H);
(584)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.62-6.64(t,IH), 6.70-6.72(d, l H), 7.43-7.45(t, l H), 7.55-7.57(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.07-8.09(d, l H), 9.02(s,2H);

(585)2-(2-pyrrolidine-1-yl-5-pyrim idinyl)-l H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) S: 1.92-1.95(m,4H), 2.45(s,3H), 3.44-3.48(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.12(s,1 H), 9.02(s,2H);

(586)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidin yl)amide 11-INMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,IH), 7.89-7.91 (d,IH), 7.82(s,1H), 7.93-7.94(d,1 H), 8.33(s,1H), 9.02(s,2H), 11.53(s,1H);
(587)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidin yl)amide 'HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 3.82(s,6H), 5.71 (s, I H), 7.43-7.45(t, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 9.02(s,2H);
(588)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimi dinyl)amide 'HNMR (DMSO, 400MHz) 5: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 5.98(s,IH), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H);
(589)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl) amide 'HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 9.02(s,2H), 9.34(s, I H);
(590)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.60-6.61(d, l H), 6.63-6.65(t, l H), 6.96-6.98(t, l H), 6.99-7.01 (d, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.02(s,2H);

(591)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimi dinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 5.46-5.48(d,IH), 7.10-7.11 (d, l H), 7.43-7.45(t, l H), 7.82(s, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.02(s,2H);

(592)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,IH), 7.86-7.88(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.16-8.18(d, I H), 9.02(s,2H);
(593)2-(2-pyrrolidine-l-yl-5-pyrimidinyl)-1H-benzimidazole 4-(N-6-hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,IH), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.57-8.59(d, I H), 9.02(s,2H), 11 .53(s, l H);
(594)(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitr ophenylhydroxyethyl)]amide 'I-1NMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.17-3.18(m,IH), 3.25-3.28(m, l H), 3.50-3.52(m, l H), 3.65-3.68(t, l H), 3.70-3.72(d, l H), 3.73-3.77(t,4H), 4.73-4.77(t, I H), 7.43-7.45(t, I H), 7.62-7.65(d,2H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 8.17-8.20(d,2H), 9.02(s,2H);

(595)(L) 2-(2-piperidine-1-y1-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-am inophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) 8: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.17-3.18(m,IH), 3.25-3.28(m, ] H), 3.50-3.52(m, I H), 3.65-3.68(t, l H), 3.70-3.72(d,1 H), 3.71-3.75(t,4H), 4.73-4.77(t,IH), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,IH), 7.89-7.90(d, l H), 7.93-7.95(d, I H), 9.02(s,2H);

(596)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N{1-methyl-2-p-chlorophenylhy droxyethyl)]amide 'HNMR (DMSO, 400MHz) 8: 1.12-1.15(d,3H), 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3 .25-3.28(m, I H), 3.65-3 .68(t, I H), 3.71-3.75(t,4H), 4.73-4.77(t, l H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.02(s,2H);

(597)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,8H), 1.59-1.63(m,2H), 3.10-3.15(t,4H), 3.71-3.75(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.02(s,2H);
(598)2-(2-piperidine-1-yl-5-pyrimidinyl}l H-benzimidazole-4-(N-2-piperazinyl)amide IHNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 1.91-1.93(m,2H), 2.62-2.63(m,I H). 2.65-2.66(m, l H), 2.69-2.70(m, I H), 2.72-2.74(m,1 H), 2.77-2.80(m, l H), 3.02-3.05(m,1 H), 3.71-3.75(t,4H), 3.99-4.01(m,1 H), 7.43-7.45(t,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 9.02(s,2H);

(599)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide I HNMR (DMSO, 400MHz) 8: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 9.02(s,2H);

(600)2-(2-piperidine-1-yl-5-pyrimidiny¾1H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.27(s,2H), 6.38-6.40(d, l H), 6.56-6.58(t,1 H), 6.75-6.76(d, I H), 7.02-7.04(t, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.02(s,2H);
(601)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.35-6.37(d, l H), 6.93(s, I H), 7.43-7.45(t,1 H), 7.54-7.56(d, I H), 7.89-7.91(d, l H), 7.93-7.94(d, l H), 9.02(s,2H);
(602)2-(2-pi peridine-l-yl-5-py rimidinyl)-1 H-benzi midazole-4-(N-4'-carbonamido-5'-i midazolyl)amide IHNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d, l H), 13.00-13.03(d,1H);

(603)2-(2-piperidine-1 yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide IHNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.61 (s, I H), 8.63-8.65(d, I H), 9.02(s,2H), 13.71-13.75(d,1 H);

(604)2-(2-piperidine-1-yl-5-pyrimidinyl} 1H-benzimidazole-4-(N-(N'-piperazinyl))amide IHNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 1.91-1.95(m,IH), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.71-3.75(t,4H), 7.43-7.45(t, I H), 7.90-7.91 (d, l H), 7.93-7.94(d, I H), 9.02(s,2H);

(605)2-(2-piperidine-1 yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide IHNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.34-8.35(d, l H), 8.36(s, I H), 8.40-8.42(d, I H), 9.02(s,2H);

(606)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide IHNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.93-6.95(t, l H), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.45-8.46(d,2H), 9.02(s,2H);

(607)2-(2-piperidine-l-yl-5-pyrimidinyl)-1H-benzimidazole-4 (N-2-pyridyl)amide IHNMR (DMSO, 400MHz) 8: 1.53-1.56(m,4H), 1.59-I.62(m,2H), 3.71-3.75(t,4H), 6.62-6.64(t, I H), 6.70-6.72(d, I H), 7.43-7.45(t, l H), 7.55-7.57(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.07-8.09(d, I H), 9.02(s,2H);

(608)2-(2-piperidine-1 yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide IHNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 2.45(s,3H), 3.71-3.75(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.12(s, I H), 9.02(s,2H);

(609)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihyd roxyl-5-pyri midinyl)amide IHNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.82(s, I H), 7.93-7.94(d, l H), 8.33(s, l H), 9.02(s,2H), l 1.53(s,1 H);

(610)2-(2-pi peridine-1-yl-5-pyri midinyl)-1 H-benzi midazole-4-(N-4,6-dimethoxy-2-pyri midinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 3.82(s,6H), 5.71(s,1 H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 9.02(s,2H);
(611)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidin yl)amide 'HNMR (DMSO, 400MHz) 8: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 5.98(s, I H), 7.43-7.45(t, l H), 7.74(s,2H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 9.02(s,2H);
(612)2-(2-piperidine-1-yl-5-pyrimidiny¾1H-benzimidazole-4-4N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.02(s,2H), 9.34(s, I H);
(613)2-(2-piperidine-1 yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 8: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 6.60-6.61 (d, l H), 6.63-6.65(t, l H), 6.96-6.98(t, I H), 6.99-7.01 (d, l H), 7.43-7.45(t, I H), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 9.02(s,2H);

(614)2-(2-piperidine-1 yI-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 5.46-5.48(d, I H), 7.10-7.11 (d, I H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.9 1 (d, I H), 7.93-7.94(d, I H), 9.02(s,2H);

(615)2-(2-piperidine-1 yl-5-pyrimidiny¾1H-benzimidazole-4-(N-&purinyf)amide 'HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t, I H), 7.86-7.88(d, I H), 7.89-7.91(d, l H), 7.93-7.94(d,1 H), 8.16-8.1 8(d, I H), 9.02(s,2H);

(616)2-(2-piperidine-1 yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-&hydroxyl-2-purinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.71-3.75(t,4H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.57-8.59(d, l H), 9.02(s,2H), 11.53(s,1 H);

(617)(L,}2-(2-cyclopropylamino-5-pyi imidinyl)-1H-benzimidazole-4-[N- (1-hydroxymethyl-2-p-nitr ophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 3.17-3.1 8(m,I H), 3.25-3.28(m, l H), 3.50-3.52(m, l H), 3.65-3.68(t, l H), 3.70-3.72(d,1 H), 4.73-4.77(t, l H), 7.43-7.45(t, l H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, l H), 8.17-8.20(d,2H), 9.02(s,2H);

(618)(L)-2 (2 cyclopropylamino-5-pyrimidiny¾1H-benzimidazoleA-[N-(1-hydroxymethyl-2-p-ami nophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 3.17-3.1 8(m, l H), 3.25-3.28(m, l H), 3.50-3.52(m,1 H), 3.65-3.68(t, I H), 3.70-3.72(d, l H), 4.73-4.77(t, I H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d, I H), 7.93-7.95(d, I H), 9.02(s,2H);

(619)2-(2 cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhy droxyethyl)]amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.12-1.15(d,3H), 1.35-1 .37(m,1 H),3.25-3.28(m, I H), 3 .65-3.68(t, l H), 4.73-4.77(t, I H), 7.29-7.30(d,2H), 7.40-7.41 (d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.02(s,2H);

(620)2{2,cyclopropylamino-5-pyrimidinyl}1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 1.52-1.55(m,4H),1.59-1.63(m,2H), 3.10-3.15(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d, I H), 9.02(s,2H);

(621)2{2cyclopropylamino-5-pyrimidiny¾1H-benzimidazole-4-(N 2-piperazinyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 1.91-1.93(m,2H), 2.62-2.63(m, I H). 2.65-2.66(m,1 H), 2.69-2.70(m, I H), 2.72-2.74(m, I H), 2.77-2.80(m, l H), 3.02-3.05 (m, I H), 3.99-4.01(m,1 H), 7.43-7.45(t, l H), 7.89-7.91(d,1 H), 7.93-7.94(d, l H), 9.02(s,2H);

(622)2 (2cyclopropylamino-5-pyrimidiny¾1H-benzimidazole 4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.02(s,2H);

(623)2.(2- yclopropylamino-5-pyi imidinyl}1H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 8: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 6.27(s,2H), 6.3 8-6.40(d, l H), 6.56-6.58(t, I H), 6.75-6.76(d, I H), 7.02-7.04(t, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 9.02(s,2H);

(624)2-(2- yclopropylamino-5-pyrimidinyl)-1H-benzimidazole 4-{N-S-benzimidazolonyl)amide ' HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1 .37(m, I H), 6.35-6.37(d, I H), 6.93(s, l H), 7.43-7.45(t, I H), 7.54-7.56(d, I H), 7.89-7.91(d, I H), 7.93-7.94(d, I H), 9.02(s,2H);
(625)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4'-carbonamido-5 '-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d, I H), 13.00-1 3.03(d, I H);

(626)2 (2-cyclopropylamino-5-pyrimidinyl}1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.61 (s, l H), 8.63-8.65(d, l H), 9.02(s,2H), 13.71-13.75(d,1H);

(627)2-(2-cyclopropylamino-5-pyrimidinyl)1H-benzimidazole 4-(N-(N'-piperazinyl))amide 1HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1 .37(m, I H), 1.91-1 .95(m, l H),2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t, I H), 7.90-7.91(d,1 H), 7.93-7.94(d, I H), 9.02(s,2H);

(628)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole 4-(N-2-pyrazinyl)amide 1HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.34-8.35(d, I H), 8.36(s, I H), 8.40-8.42(d, I H), 9.02(s,2H);

(629)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4(N 2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.93-6.95(t, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 8.45-8.46(d,2H), 9.02(s,2H);

(630)2-(2-yclopropylamino-5-pyrimidinyl)-1H benzimidazole 4-(N 2-pyridyl)amide 1HNMR (DMSO, 400MHz) 8: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 6.62-6.64(t, l H), 6.70-6.72(d, I H), 7.43-7.45(t, I H), 7.55-7.57(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.07-8.09(d, I H), 9.02(s,2H);

(631)2-(2rcyclopropylamino-5-pyrimidinyl)- H benzimidazole {N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) S: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 2.45(s,3H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.12(s,1 H), 9.02(s,2H);
(632)2-(2-cyclopropyla m ino-5-pyrimidinyl)-1 H-benzim idazole-4-(N-2,4-d ihyd roxyl-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 8: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t, I H),7.89-7.91(d, l H), 7.82(s, l H), 7.93-7.94(d, I H), 8.33(s, l H), 9.02(s,2H), 11.53(s,1 H);
(633)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-(N-4,6-dimethoxy-2-p yrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 3.82(s,6H),5.71(s, I H), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d,1 H), 9.02(s,2H);
(634)2-(2-yclopropylamino-5-pyrimidinyl)-1H-benzimidazole -(N-4-chloro-6-amino-2-pyrimidin yl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), .98(s, l H), 7.43-7.45(t,1 H), 7.74(s,2H), 7.89-7.91 (d, l H), 7.93-7.94(d, I
H), 9.02(s,2H);

(635 (2-cydopropylamino-5-pyrimidinyl}1H benzimidazole4-(N-4,6-(ichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, l H), 9.02(s,2H), 9.34(s, I H) ;

(636)2 (2-cydopropylamino-5-pyrimidinyl}1H benzimidazole-4{N-Buomphenyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 6.60-6.61(d, l H), 6.63-6.65(t.1 H), 6.96-6.98(1.1 H), 6.99-7.01(d, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 9.02(s,2H);

(637 (2-cydopropylamino-5-pydnidinyl)-1H-benzimidazole-4-(N 2-hydroxyl-4-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 5.46-5.48(d, I H), 7.10-7.11(d,1 H), 7.43-7.45(t, l H), 7.82(s, I H), 7.89-7.91(d, I H), 7.93-7.94(d,IH), 9.02(s,2H);

(638)2 (2-cydopropylamino-5-pyrimidinyl -1H-benzimidazole-4-(N-6-purinyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 7.43-7.45(t, l H), 7.86-7.88(d,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.16-8.1 8(d, l H), 9.02(s,2H);

(639)2-(2-cydopropylamino-5-pyrimidinyl)-1H-benz;midazok4 {N-6-hydroxyl-2-pururyl)amide 'HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,IH), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.57-8.59(d, I H), 9.02(s,2H), 11.53(s,IH);

(640)(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-[N-(1-hyd roxymet hyl-2-p-n itrophenyl hyd roxyethyl)] amid e 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.17-3.1 8(m, l H), 3.25-3 .28(m, I H), 3.50-3.52(m, I H), 3.65-3.68(t, I H), 3.70-3.72(d, I H), 3.95(s,3H), 4.73-4.77(t, l H), 7.43-7.45(t, I H), 7.62-7.65(d,2H), 7.89-7.90(d, l H), 7.93-7.95(d, l H), 8.17-8.20(d,2H);

(641)(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-[N-(1-hyd roxymet hyl-2-p-aminophenylhydroxyethyl)lamide I HNMR(DMSO,400MHz)5:2.06(s,3 H),3.17-3.18(m, I H),3.25-3.28(m, I H),3.50-3.52( m, I H),3.65-3.68(t, I H),3.70-3.72(d, I H),3.95(s,3H),4.73-4.77(t, I
H),6.27(s,2H),6.56-6.58(d, 2H),7.11-7.13(d,2H),7.43-7.45(t, I H),7.89-7.90(d, I H),7.93-7.95(d, I H);

(642)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-(1-methyl-2-p-chlo rophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) b: 1.12-1.15(d,3H), 2.06(s,3H), 3.25-3.28(m,1H), 3 .65-3.68(t, I H), 3.95(s,3H), 4.73-4.77(t, I H), 7.29-7.30(d,2H), 7.40-7.41 (d,2H), 7.43-7.45(t, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);

(643)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.06(s,3H), 3.10-3.15(t,4H), 3.95(s,3H), 7.43-7.45(t,IH), 7.89-7.91(d,IH), 7.93-7.94(d,IH);

(644) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 'HNMR (DMSO,400MHz)6: 1.91-1.93(m,2H), 2.06(s,3H), 2.62-2.63(m,1H), 2.65-2.66(m, l H), 2.69-2.70(m, I H), 2.72-2.74(m, I H), 2.77-2.80(m,1 H), 3.02-3.05(m, I H), 3.95(s,3H), 3.99-4.01 (m, I H), 7.43-7.45(t, I H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H);

(645)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(646)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-o-aminophenyl)amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 6.27(s,2H), 6.38-6.40(d,IH), 6.56-6.58(t, I H), 6.75-6.76(d, l H), 7.02-7.04(t, l H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H);

(647)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 6.35-6.37(d,IH), 6.93(s,IH), 7.43-7.45(t, I H), 7.54-7.56(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(648)2-(1,3-dimethyl-5-chloro-4-pyrazolyl}1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazo lyl)amide 'HNMR (DMSO, 400MHz) 5: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 8.37(s,2H), 9.24-9.26(d, I H), 13.00-13.03(d, I H);

(649) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,IH), 7.89-7.91(d,1 H), 7.93-7.94(d,1 H), 8.61(s,1 H), 8.63-8.65(d,1 H), 13.71-1 3.75 (d, I H) ;
(650)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)1H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,IH), 2.06(s,3H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.95(s,3H), 7.43-7.45(t,1 H), 7.90-7.91(d,1 H), 7.93-7.94(d,1 H);
(651)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) 8: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.34-8.35(d, I H), 8.36(s,1 H), 8.40-8.42(d, ] H);
(652)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole 4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 6.93-6.95(1,1 H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.45-8.46(d,2H);
(653)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole 4-(N-2-pyridyl)amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 6.62-6.64(t, l H), 6.70-6.72(d, I H), 7.43-7.45(t,1 H), 7.55-7.57(t,1 H), 7.89-7.91(d,I H), 7.93-7.94(d,1 H), 8.07-8.09(d, I H);

(654)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 2.45(s,3H), 3.95(s,3H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.12(s, I H);

(655)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidin yl)amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,IH), 7.89-7.91(d.IH), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H);
(656)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidin yl)amide 'HNMR (DMSO, 400MHz) 8: 2.06(s,3H), 3.82(s,6H), 3.95(s,3H), 5.71(s,IH), 7.43-7.45(t,1 H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(657)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimi dinyl)amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 5.98(s, I H), 7.43-7.45(t,1 H), 7.74(s,2H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(658)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dichlo%5-pyrimidinyl) amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d,1 H), 9.34(s, l H);

(659)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR(DMSO,400MHz)5:2.06(s,3H), 3.95(s,3H), 6.60-6.61(d,1H), 6.63-6.65(t,IH), 6.96-6.98(t, I H), 6.99-7.01 (d, I H), 7.43-7.45(t, l H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(660)2 (1,3-dimethyl-5-chiorad-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide ' 1-INMR(DMSO,400MHz)6:2.06(s,3H), 3.95(s,3H), 5.46-5 .48(d, I H), 7.10-7.11 (d, I H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,IH);
(661)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-6-purinyl)amide 'HNMR(DMSO,400MHz)8:2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,IH), 7.86-7.88(d,IH), 7.89-7.91 (d,1 H), 7.93-7.94(d,1 H), 8.16-8.1 8(d, I H);
(662)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-puri nyl)amide 'HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H). 7.43-7.45(t,IH), 7.89-7.91(d,IH), 7.93-7.94(d,IH), 8.57-8.59(d,IH), 11.53(s,iH);
(663)2-(4-hydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (refer to Figure 5) 1 HMNR(DMSO,400MHz)5:7.13-7.19(m. l H),7.23-7.27(t, I H),7.36-7.41 (t, l H),7.50-7.5 4(m,2H), 7.85-7.87(d, I H), 7.94-7.95(d, I H), 8.05-8.07(d, I H), 8.57-8.61 (t, l H), 12.19-12.20(d,IH), 14.25(s, I H);

(664)(L)-2-(3-hydroxyphenyl)-1 H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophe nylhydroxyethyl))amide (refer to Figure 6) ' HNMR(DMSO,400MHz)8:3.51-3.57(m,1 H),3.64-3.72(m, I H),4.22-4.26(m, I H),5.05-5.08(q, I H),5.25-5.27(d, I H),6.16-6.18(d, I H),6.95-6.98(d, I H), 7.23-7.27(t, I H),7.30-7.34(t, I H),7.36-7.40(m, I H),7.65-7.73(m,4H),7.80-7.84(m, I H), 8.03-8.10(m,2H), 9.76(s, I H), 10.43-10.46(d,1 H), 13.31(s,1 H);
(665)2-(3-hydroxyphenyl)-1 H-benzimidazole-4-(N-6-hydroxyl-2-pu rinyl)am ide 'HNMR (DMSO, 400MHz) 8: 5.35(s,IH), 6.91-6.93(d,IH), 7.04(s,1H), 7.34-7.36(d, I H), 7.43-7.45(t, I H), 7.84-7.86(d, l H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.57-8.59(d,IH), 11.53(s,IH)a Examples 666-688 1.Og of 2,3-diaminobenzoic acid is dissolved into 20m1 of glacial acetic acid.
Triethyl orthoformate (2.1eq.) is added into the above mixture at temperature of 0 C; and to stir it for 2 hours at temperature of 0 --5 C; and 150ml of water is added into it, and then to isolate and filter to produce 2-ethoxy-1 H-benzimidzzole-4-formic acid. The yield is about 89%. 2-ethoxy-1H-benzimidzzole-4-formic acid is added into 15m1 of thionyl chloride, and to react for 60 minutes, and after end ofthe reaction 'completely, and (L)-2-amino-l-p-nitrophenyl-1,3-propylene glycol (1.leq) is added into the reaction mixture under stirring for 2 hours at the room temperature, and then to filter the inorganic salt, and evaporate the solvent to dry, to obtain the final product of (L)-2-ethoxy-I H-benzim idazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)am i de. The yield is about 91%. Using the same process to prepare the compounds in Table 3.

N
/ NH
Table 3 No. Compounds X Y Field OZN
(L)-2-ethoxy-1 H-benzimidazole-4-[N "
H OH
666 _(1-hydroxymethyl-2-p-nitrophenylhy -odic"3 / 94 HO %" H
droxyethyl)]amide HzN
(L)-2-ethoxy-IH-benzimidazole-4-[N "
H OH

(I ~iCH3 H 91 NH
HO / H
hydroxyethyl)]amide 2-ethoxy-IH-benzimidazole-4-[N-(1- c H
H
668 methyl-2-p-chlorophenylhydroxyethy - 'ic"3 CH3 92 NH
/
1)]amide HO
669 2-ethoxy- I H-benzimidazole-4-(N-__-o cH N\N 92 N'-piperidinyl)amide ~~ ' H
2-ethoxy-IH-benzimidazole-4-(N- HN~NJ\
670 `

2-piperazinyl))amide c"3 N
H

671 2-ethoxy-1 H-benzimidazole-4-(N- o~ N
2'-benzimidazolyl)amide ~c"3 (:::CN 94 H
H
672 2-ethoxy-I H-benzimidazole-4-(N- al~ 89 N
o-aminophenyl)amide NH
z 673 2-ethoxy- I H-benzimidazole-4-(N- o\--cH, I N o 5-benzimidazolonyl)amide N / H
H
H
2-ethoxy- I H-benzim idazole-4-(N- /N "
~
674 4'-carbonamido-5'-imidazolyl)ami o \iCH, H2N I N 86 de H
675 N , N
2-ethoxy- I H-benzimidazole-4-(N- ~o~icH, / 93 4'-pyrazolyl)amide NH

676 2-ethoxy- I H-benzim idazole-4-(N- \~CH, N-NH 91 (N'-piperazinyl))amide N
677 2-ethoxy-I H-benzimidazole-4-(N- o cH \
2-pyrazinyl)amide H N 92 H

678 2-ethoxy- I H-benzim idazole-4-(N- o CH \ , 92 2 pyrimidinyl)amide N N
H

679 2-ethoxy-IH-benzimidazole-4-(N-2-pyridyl)amide tic"3 \N
H
CH, 680 2-ethoxy-]H-benzimidazole-4-(N- o CH, N

4-methyl-5-thiazolyl)amide / S H

2-ethoxy- I H-benzim idazole-4-(N- "-C= HO_ / N`
681 2,4-dihydroxyl-5-pyrimidinyl)ami \icH, 85 OH
de 2-ethoxy- I H-benzim idazole-4-(N- N_ OCHE 682 4,6-dimethoxy-2-pyrimidinyl)amid oCH, ,N\ 94 N
e OCHE
CI
2-ethoxy- I H-benzim idazole-4-(N- /N_ 683 4-chloro-6-amino-2-pyrimidinyl)a o\~cH3 N--(~ 89 N
mide NH2 G

684 2-ethoxy- I H-benzimidazole-4-(N- o CN, N H
4,6-dichloro-5-pyrimidinyl)amide NJ
685 2-ethoxy- I H-benzimidazole-4-(N- o CH, N
\~ 93 o-fluorophenyl)amide F
INH
686 2-ethoxy-1 H-benzimidazole-4-(N- ---o~~cH, 87 2-hydroxyl-4-pyri midinyl)am ide HO N
IH
687 2-ethoxy- I H-benzimidazole-4-(N- o CH 93 6-purinyl)amide ' ~~ "I I DIN

N N"
OH

688 2-ethoxy-lH-benzimidzzole-4-(N- o CH 88 6-hydroxyl-2-purinyl)amide ' -N \N N
H H
Structure Identification of Products (666)(L)-2-ethoxy-1H-benzimidazole-4-[N-(l-hydroxymethyl-2-p-nitrophenylhydroxyethyl)Jamide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 3.17-3.18(m,IH), 3.25-3.28(m,IH), 3.50-3.52(m, l H),3.65-3.68(t, l H), 3.70-3.72(d, l H), 4.29-4.33(m,2H), 4.73-4.77(t, I H), 7.43-7.45(t,I H),7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H);

(667)(L}2-ethoxy-1H benzimidazole-d-[N-(l-hydmxymethyl-2-p-aminophenylhydroxyethyl)]amide 'HNMR (DMSO, 400MHz) S: 1.32-1.35(t,3H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m, l H),3.65-3.68(t, I H), 3.70-3.72(d, I H), 4.29-4.33(m,2H), 4.73-4.77(t, l H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t, I H), 7.89-7.90(d, I H), 7.93-7.95(d, I H);

(668)2-ethoxy-lILbenzimidazole-4-[N41-methy>- p-chlorophenylhydroxyethy>)]amide 'HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.32-1.35(t,3H), 3.25-3.28(m,IH), 3 .65-3.68(t, l H), 4.29-4.33(m,2H), 4.73-4.77(t, I H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H);

(669)2-ethoxy-1H benzimidazole (N-N'-piperidinyl)amide IHNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 1.52-1.55(m,4H), 1.59-1.63(m,2H), 3.10-3.1 5(t,4H),4.29-4.33(m,2H),7.43-7.45(t, I H), 7.89-7.91(d,I H), 7.93-7.94(d, l H);
(670)2-ethoxy--1H benzimidazo e-4-(N-2-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 1.91-1.93(m,2H), 2.62-2.63(m,IH), 2.65-2.66(m, l H), 2.69-2.70(m. I H), 2.72-2.74(m, l H), 2.77-2.80(m, l H), 3.02-3.05(m, I H), 3.99-4.01 (m, I H), 4.29-4.33(m,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H);
(671)2-ethoxy-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 'HNMR (DMSO, 400MHz) S: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);

(672)2-ethoxy-1 H-benzimidazole-4-(N-o-am inophenyl)amide 'HNMR (DMSO, 400MHz) S: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.27(s,2H), 6.38-6.40(d, l H), 6.56-6.58(t, l H), 6.75-6.76(d, l H), 7.02-7.04(t, I H), 7.43-7.45(t, I H), 7.89-7.91(d, l H), 7.93-7.94(d, I H);

(673)2-ethoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.35-6.37(d,IH), 6.93(s, l H), 7.43-7.45(t,1 H), 7.54-7.56(d,1 H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);
(674)2-ethoxy-1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d, I H), 8.37(s,2H), 9.24-9.26(d, l H), 13.00-13.03(d, I H);
(675)2-ethoxy-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,IH), 7.89-7.91(d,1H), 7.93-7.94(d,IH), 8.61(s,IH), 8.63-8.65(d,IH), 13.71-13.75(d,IH);
(676)2-ethoxy-1 H-benzimidazole-4-(N-(N'-piperazinyl))amide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 4.29-4.33(m,2H), 7.43-7.45(t, I H), 7.90-7.91 (d, I H), 7.93-7.94(d, I H);
(677)2-ethoxy-1 H-benzim idazole-4-(N-2-pyrazinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,IH), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.34-8.35(d, l H), 8.36(s, I H), 8.40-8.42(d, I H);
(678)2-ethoxy-1 H-benzimidazole-4-(N-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.93-6.95(t,IH), 7.43-7.45(t, I H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H), 8.45-8.46(d,2H);

(679)2-ethoxy-1 H-benzimidazole-4-(N-2-pyridyl)am ide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.62-6.64(t,IH), 6.70-6.72(d, I H), 7.43-7.45(t,I H), 7.55-7.57(t,I H), 7.89-7.91 (d, ] H), 7.93-7.94(d,I H), 8.07-8.09(d, I H);

(680)2-ethoxy-1 H-benzi midazole-4-(N-4-methyl-5-thiazolyl)amide 'HNMR (DMSO, 400MHz) S: 1.32-1.35(t,3H), 2.45(s,3H), 4.29-4.33(m,2H), 7.43-7.45(t, IH), 7.89-7.91(d,1 H), 7.93-7.94(d, I H), 8.1 2(s, l H);
(681)2-ethoxy-1H-benzimidazole-4-(N-2,4-dihyd roxyl-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 8: 1.32-I.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,IH), 7.82(s, I H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H), 8.33(s,1 H), 11.53(s, I H) ;
(682)2-ethoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 3.82(s,6H), 4.29-4.33(m,2H), 5.71 (s, l H), 7.43-7.45(t, I H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H);
(683)2-ethoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidi nyl)amide 'HNMR (DMSO, 400MHz) S: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 5.98(s, ] H), 7.43-7.45(t, I H), 7.74(s,2H), 7.89-7.91 (d, l H), 7.93-7.94(d, I H);

(684)2-ethoxy-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 'HNMR (DMSO, 400MHz) S: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,]H), 7.89-7.91 (d,1 H), 7.93-7.94(d, I H), 9.34(s, I H);

(685)2-ethoxy-1 H-benzimidazole-4-(N-o-fluorophenyl)amide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.60-6.61(d, I H), 6.63-6.65(t,1 H), 6.96-6.98(t, ] H), 6.99-7.01(d,1 H), 7.43-7.45(t,1 H), 7.89-7.91 (d, ] H), 7.93-7.94(d,I H);

(686)2-ethoxy-1 H-benzimidazole-4-(N-2-hydroxyl-4-py ri m id i nyl)a m ide 'HNMR (DMSO, 400MHz) S: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 5.46-5.48(d,1H), 7.10-7.11 (d, l H), 7.43-7.45(t,1 H), 7.82(s, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, I H);
(687)2-ethoxy-1 H-benzimidazole-4-(N-6-pu rinyl)amide 'HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,IH), 7.86-7.88(d, I H), 7.89-7.91 (d, I H), 7.93-7.94(d, l H), 8.16-8.18(d, I H) ;

(688)2-ethoxy-1 H-benzi m idzzole-4-(N-6-hydroxyl-2-pu ri nyl)a m id e 'HNMR (DMSO, 400MHz) S: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,IH), 7.89-7.9 1(d, I H), 7.93-7.94(d, l H), 8.57-8.59(d, I H), 11 .53(s, I H) Meatures of Properties:
1. Meatures of anti-coxsackie B3 viruses activity of the compounds The products are applied for meatures of antivirus properties of Vero cells.
Refer to the results of Table 3: datum of anti -coxsackie B3 viruses activities of some compounds.

Table 3 NAME OF COMPOUNDS X Y IC4 g/ml) (L)-2-(2-pyridyl)-1 H-benzimidazole- 02N

4-[N-(1-hydroxymethyl-2-p-nitrophe _ I / H L)21~J((H 1.76 ~! H
nylhydroxyethyl)]amide HO
CI
2-(2-pyridyl)-1H-benzimidazole-4-[ OH H H
_0 N H
N-(1-methyl-2-p-chlorophenylhydro H 4.115 xyethyl)]amide H
2-(3-pyridyl)-1 H-benzimidazole-4-[ CI
N \ H
N-(] -methyl-2-p-chlorophenylhydro 1Y ( / " H H 2.37 ~--~
xyethyl)]amide H H

(L)-2-(2-thienyl)- I H-benzimidazole- H
H
4-[N-(I-hydroxymethyl-2-p-nitrophe H H 15.90 nylhydroxyethyl)]amide H
CI
2-(2-thienyl)-1 H-benzimidazole-4-[ H
N-(I-methyl-2-p-chlorophenylhydro I/ H H H 5.30 xyethyl)]amide H
H
02N(/
(L)-2-(5-nitro-2-thienyl)-]H-benzimi \ H H
dazole-4-[N-(1-hydroxymethyl-2-p- H 10.69 nitrophenylhydroxyethyl)]amide H
HO
CI
2-(5-nitro-2-thienyl)-1H-benzimidaz H
ole-4-(N-(1-methyl-2-p-chloropheny N I / OH H H 7.12 lhydroxyethyl))-amide H
H
2-thienyl-IH-benzimidazole-4-(N 1.06 -(2-fluorophenyl)-amide l x 245-nitro-2-thienyl)-I H-benzimidaz I / >9.25 ole-4-(N-(2-fluorophenyl))-amide (L)-2-(5-amino-2-thienyl)-IH-ben NH2 H
zimidazole-4-[N-(1-hydroxymeth H H H 2 3 yl-2-p-nitrophenylhydroxyethyl)]
amide H
HO
2-(5-amino-2-thienyl)-I H-benzim NH2 idazole-4-(N-o-fluorophenyl)amid 3.5 e 2-(5-amino-2-thienyl)-1 H-benzimi 8.7 dazole-4-(N-o-methylphenyl)amide 2-(5-amino-2-thienyl)-I H-benzim NH2 idazole-4-(N-p-hydroxyphenyl)a 6.5 mide H
N
2-(4-methoxypyridyl)-I H-benzim idazole-4-(N-o-fluorophenyl)amid 10.2 e OCH3 (L)-2-(4-methoxypyridyl)- I H-ben iN
I H
zimidazole-4-[N-(I-hydroxymeth H H
yl-2-p-nitrophenylhydroxyethyl)] H 6.3 amide OCH3 H
HO
PN
2-(4-methoxypyridyl)- I H-benzim idazole-4-(N-o-hydroxyphenyl)a OH
i I 16.2 mide OCH3 2-(4-methoxypyridyl)-I H-benzim QN idazole-4-(N-p-aminophenyl)ami 13.4 de OCH3 NH2 (L)-2-(6-methoxypyridyl)-1 H-ben O2N
zimidazole-4-[N-(1-hydroxymeth N OCH3 H " " H 11.2 yl-2-p-nitrophenylhydroxyethyl)]
amide "
HO
2-(6-methoxypyridyl)- I H-benzim N OCH3 F
idazole-4-(N-o-fluorophenyl)amid ~ \ 14.1 e 2-(6-methoxypyridyl)- I H-benzim N OCH3 on idazole-4-(N-o-hydroxyphenyl)a 15.7 mide 2-(6-methoxypyridyl)- I H-benzim N OCH3 idazole-4-(N-p-aminophenyl)ami ~ 1 16.8 de (L)-2-(4-dimethylaminopyridyl)-1 N 02N H
H-benzimidazole-4-[N-(1-hydrox ( H "
ymethyl-2-p-nitrophenylhydroxye H 10.2 thyl)]amide N(CH3)2 HO H
2-(4-dimethylaminopyridyl)-1H-b Y N
enzimidazole-4-(N-o-fluoropheny 9.6 ])amide N(CH0)2 2-(4-dimethylaminopyridyl)-1H-b N OH
enzimidazole-4-(N-o-hydroxyphe L1) i I 9.8 nyl)amide N(CH,)2 2-(4-dimethylaminopyridyl)-I H-b N
enzimidazole-4-(N-p-aminopheny y 10.2 ])amide N(CH3)2 NH1 (L)-2-(3-pyridazinyl)-1 H-benzimi O2N
dazole-4-[N-(1-hydroxymethyl-2- N=N H H 5 8 p-n itrophenylhydroxyethyl)]amid H
e H
N
2-(3-pyridazinyl)-IH-benzimidaz N
12.3 ole-4-(N-o-fluorophenyl)amide ~

OH
2-(3-pyridazinyl)-IH-benzimidaz N,N 15.2 ole-4-(N-o-hydroxyphenyl)amide 2-(3-pyridazinyl)-1 H-benzimidaz N =N
10.2 ole-4-(N-p-aminophenyl)amide (L)-2-(2-N-methyl-4-N-methylpip CH3 o2N "
erazinyl)-I H-benzimidazole-4-[N EN) H 9.2 -(1-hydroxymethyl-2-p-nitrophen N
ylhydroxyethyl)]amide CH3 HO H
2-(2-N-methyl-4-N-methylpiperaz N H' inyl)-1H-benzimidazole-4-(N-o-fl () 8.9 uorophenyl)amide C, H3 eH3 OH
2-(5-methy-2-thienyl)-1 H-benzim idazole-4-(N-o-hydroxyphenyl)a i I 18.5 mide 2-(2-N-methyl-4-N-methylpiperaz N
inyl)-1H-benzimidazole-4-(N-p-a C ) 1 3.5 minophenyl)amide I NH2 (L)-2-(2-pyrazinyl)- I H-benzimida N \ H
zole-4-[N-(1-hydroxymethyl-2-p- C) / H 2.3 nitrophenylhydroxyethyl)]amide \N
H
HO

F
N
2-(2-pyrazinyl)-I H-benzimidazol l / 6.5 e-4-(N-o-fluorophenyl)amide NJ

OH
N
2-(2-pyrazinyl)-1H-benzimidazol l I 3.5 e-4-(N-o-hydroxyphenyl)amide N) N
2-(2-pyrazinyl)- I H-benzim idazol ~) 1 4.2 e-4-(N-p-aminophenyl)amide N
N Hz zN
(L)-2-N-piperazinyl-lH-benzimid N O H
azole-4-[N-(I -hydroxymethyl-2-o C N) H 4.2 -nitrophenylhydroxyethyl)]amide HO
N
2-N-piperazinyl-I H-benzimidazol C N) F
4.8 e-4-(N-o-fl uoropheny l )amide 2-N-piperazinyl-I H-benzimidazol (NN) 6.3 e-4-(N-p-aminophenyl)amide NHZ
(L)-2-(4-methyl-5-aminothiazolyl O2N
)-IH-benzimidazole-4-[N-(1-hydr s H
H 8.9 oxymethyl-2-p-nitrophenylhydrox CH3 yethyl)]amide NH2 HO H
2-(4-methyl-5-am inothiazolyl)- I NHS
H-benzimidazole-4-(N-o-fluoroph CH3/z~y 10.2 enyl)amide NH2 2-(4-methyl-5-aminothiazolyl)-l Nis H-benzimidazole-4-(N-p-aminoph cH,/,,/ 9.8 enyl)amide NH2 NH, (L)-2-thiazolyl-IH-benzimidazole N-;~\ H H
-4-[N-(1-hydroxymethyl-2-p-nitro I s 11.2 phenylhydroxyethyl)]amide HO

5-thiazolyl- I H-benzimidazole-4-( NHS 13.5 N-p-aminophenyl)amide ~
N H, (L)-2-(3,4,5-trihydroxyphenyl)-1 O2N
OH "
H-benzimidazole-4-[N-(1-hydrox OH OH " H 10.2 ymethyl-2-p-nitrophenylhydroxye H
thyl)]amide HO H
2-(2,3,4-trihydroxyphenyl)-1 H-be OH
nzimidazole-4-(N-p-hydroxyphen OH I off 11.2 yl)amide H
(L)-2-(2-pyrimidinyl)-l H-benzimi O,N
dazole-4-[N-(I-hydroxymethyl-2- N^- N ( \ H H
p-nitrophenylhydroxyethyl)]amid / H 9.8 e HO

2-(2-pyrimidinyl)-1H-benzimidaz NON
ole-4-(N-o-fluorophenyl)amide -1 / 8.8 OH
2-(2-pyrimidinyl)-IH-benzimidaz N' N
ole-4-(N-o-hydroxyphenyl)amide I 7.8 2-(2-pyrimidinyl)-1 H-benzimidaz NON
9.8 ole-4-(N-p-aminophenyl)amide OL -2-(2-hen 1-5- rimidin 1 I 2N
P Y PY Y )- H
H-benzimidazole-4-[N-(1-hydrox H "
ymethyl-2-p-n itrophenylhydroxye " 12.0 thyl)]amide HO H
2-(2-phenyl-5-pyrimidinyl)-1 H-be nzimidazole-4-(N-o-fluorophenyl) 12.6 amide Nt\J

2-(2-phenyl-5-pyrimidinyl)-IH-be OH
nzimidazole-4-(N-o-hydroxyphen I 13.2 yl)amide 2-(2-phenyl-5-pyrimidinyl)-1H-be I
nzimidazole-4-(N-p-aminophenyl 15.2 )amide " / ! NH2 (L)-2-(4-amino-6-chloro-5-pyrimi ci N 2N
d nyl)-1 H-benzimidazole-4-[N-(1 1 H H 17.2 y oxymethyl-2-p-nitrophenylh ydroxyethyl)]amide NHz H
2-(4-amino-6-chloro-5-pyrimidin cl /N
yl)-I H-benzimidazole-4-(N-o-fluty 11.3 orophenyl)amide N H2 2-(4-amino-6-chloro-5-pyrimidin cl N OH
yl)-1 H-benzimidazole-4-(N-o-hyd N 12.3 roxyphenyl)amide N H2 2-(4-amino-6-chloro-5-pyrimidin cIN
yl)- I H-benzimidazole-4-(N-p-ami N 14.1 nophenyl)amide NH2 NHZ

(L) -2 -(2 -pyrro I y 1) - I H-benzimidaz O2N H
ole-4-[N-(1-hydroxymethyl-2-p-n ON " H H 5.3 _) . .
itrophenylhydroxyethyl)]amide H

HO

2-(2-pyrrolyl)- I H-benzimidazole- 9 2 4-(N-o-fluorophenyl)amide ON
OL -2-(3,5-dimeth 1-2-rrol 1)- I
Y PY Y cH3 H
H-benzimidazole-4-[N-(1-hydrox N I " " H 8.6 ymethyl-2-p-nitrophenylhydroxye thyl)]amide HO H
2-(3,5-dimethyl-2-pyrrolyl)-1H-b cH3 -q ;N OH
enzimidazole-4-(N-o-hydroxyphe 10.2 nyl)amide CH3 (L)-2-(N-methyl-2-pyrrolyl)-1 H-b O,N
enzimidazole-4-[N-(1-hydroxyme 11.1 thyl-2-p-nitrophenylhydroxyethylCIN_CH3 )]amide HO 2-(N-methyl-2-pyrrolyl)-1 H-benzi midazole-4-(N-o-fluorophenyl)am CNH3 13.2 ide (L)-2-(2-piperidinyl)-1 H-benzimi O2N
:::) H dazole-4-[N-(I -hydroxymethyl-2- No " 17.2 p-nitrophenylhydroxyethyl)]amid HO
e 2-(2-quinolinyl)- I H-benzimidazol 0 15.3 e-4-(N-o-fluorophenyl)amide -N'1 NH
2-(3-indolyl)- I H-benzimidazole-4 10.8 -(N-p-aminophenyl)am ide CV

(L-)2-(3-indolyl)-1 H-benzimidazo NH \ H "
le-4-[N-(1-hydroxymethyl-2-p-nit 1I / 9.6 rophenylhydroxyethyl)]amide HO

RBV - - 353.55 In the above table: "-" indicates that these samples don' t have anti-coxsackie B3 viruses activities at the maximum nontoxic dose.

IC50 indicates half inhibitary concentration for viruses.

RBV indicates triazole nucleoside, is also called ribavirin, virazole.

It may be seen from the result of test, these compounds have better properties of anti-coxsackie B3 viruses. These compounds of the present invention have better effects on the coxsackie viruses of the picornaviridae and can inhibit coxsackie viruses.
Although the present invention has been described in connection with the above embodiments, it should be understood that the present invention is not limited to such preferred embodiments and procedures set forth above. The embodiments and procedures were chosen and described in order to best explain the principles of the invention and its practical application, to thereby enable others skilled in the art to best utilize the invention.
It will be apparent to those skilled in the art that various substitution, modifications and changes may be thereto without departing from the scope and spirit of the invention.
Therefore, the intention is intended to cover all alternative constructions and equivalents falling within the spirit and scope of the invention as defined only by the appended claims and equivalents thereto.

Claims (13)

1. The benzimidazole-4-carboxamide derivatives of Formula (I) or pharmaceutically acceptable salts thereof, wherein, X represents monosubstituted or bissubstituted or polysubstitued C1-alkoxy, monosubstituted or bisubstituted or polysubstitued C1-C14 alkyl, monosubstituted or bisubstituted or polysubstitued C2-C4 alkenyl, monosubstituted or bisubstituted or polysubstitued C6-C14 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom;

Y represents hydrogen, monosubstituted or bisubstituted or polysubstitued C1-alkyl, monosubstituted or bisubstituted or polysubstitued C6-C12 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom;
wherein, X is selected from one of the following groups:
wherein, R is selected from -H, or , wherein, n=0~5, R wy1, R wy2, R wy3, R wy4 and R wy5 are respectively and independently selected from -H, -CH3, or -CH2CH3;

n=0~5; R1, R2, R3, R4 and R5 are respectively and independently selected from -H, -CH3, -F, -Cl, -Br, -1, -OH, -OCH3, -OCH2CH3, -NO2, -NH-CH3, -NH-CH2CH3, -NH-CH2CH2OH, CH3-~-CH3, CH3-~-CH2CH3, CH3-~-CH2CH2OH, CH3CH2-~-CH2CH3, CH3CH2-~-CH2CH2OH, OHCH2CH2~-CH2CH2OH or phenyl substituted by one or several substituents Ra, Ra is selected from -F, -Cl, -Br, -1, -CH3, -CH2CH3, -OH, -OCH3, -OCH2CH3, -CH2CH2OH, -NO2, -NH2, -N(CH3)2, -N(CH2CH3 )2, -N(CH2CH2OH )2, -CN, -COOH, -COOCH3, -COOCH2CH3, or -COOC6H5;
R1', R2' and R3' are respectively and independently selected from -H, -CH3, -CH2CH3, or , wherein n is an integer between 0 and 5; R1" and R2" are respectively and independently selected from -H, -CH3, or -CH2CH3;

R9, R10, R11, R12 and R13 are respectively and independently selected from -H, -CH3, -CH2CH3, -COOH, -COOCH3, -COOCH2CH3, -OH, -OCH3, -OCH2CH3, -CN, -F, -Cl, -Br, -I, or -NH2, -N(CH3)2, or -N(CH2CH3)2;

R17, R18, R19, R20, R'17, R'18, R'19, R'20, R"17, R"18, R"19 and R"20 are respectively and independently selected from -H, -CH3, -CH2CH3, -OH, -OCH3, -OCH2CH3, -CF3, -CC13, -CBr3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -NO or -NO2, which cannot represent H simultaneously;

R23, R24, R25, R'23, R'24 and R'25 are respectively and independently selected from -H, -CH3, -CH2CH3, -F, -Cl, -Br, -1, -OH, -OCH3, -OCH2CH3, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -COOH, -COOCH3, or -COOCH2CH3;

R29, R30 and R31 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2;

R34, R36 and R41 are respectively and independently selected from -H, -(CH2)n CH3, -CH2OH, -CH2CH2OH, -CH(CH3)2 or -CH2CH(OH)CH3, n is an integer between 0 and 5;
R35, R37, R38, R39, R40, R42 and R43 are respectively and independently selected from -H, -CH3, -CH7CH3, -OCH3, -CH7OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2;

Z is selected from N, O or S.
R44, R45, R46, R'44, R'45 and R'46 are respectively and independently selected from -H, -CH3, -CH2CH3, -OH, -OCH3, -OCH2CH3, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH-,CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -CN or -COOH, -COOCH3, or -COOCH2CH3;

R s1, R s2, R's1 and R's2 are respectively and independently selected from -H, -CH3, -CH2CH3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH7CH7OH)2, -F, -Cl, -Br, -I, or NHCOCH3, NHCOCH2CH3, or NHCOC6H5;

R m1, R m2, R m3, R'm1, R'm2 and R'm3 are respectively and independently selected from -H, -CH3, -CH2CH3, -F, -Cl, -Br, -1, -OH, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, , or -NHC6H5;

R k1, R k2, R k3, R k4, R k5 and R k6 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2;

R p1, R p2 , R p3 and R p4 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 ~ -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2;

R y1, R y2, R y3 ~ R y4 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2;

Rmz1 is selected from -H, -CH3, -CH2CH3, -CH2CH2OH, -C6H5, or -CH2C6H5; Rmz2 and Rmz3 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2;

Rbz1 is selected from -H, -CH3, -CH2CH3, -CH2CH2OH, -C6H5, or -CH2C6H5; Rbz2 and Rbz3 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2;
Y is selected from one group of the following groups:

wherein, R50, R51, R52, R53, R54, R55, R56, R57, R58, R59, R60, R61, R62, R63, R64, R65, R66, R67, R68, R69, R70, R71, R72 and R73 are respectively and independently selected from -H, -CH3, -CH2CH3, -CH2OH, -OH, -OCH3, -OCH2CH3, -CN, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH7CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -F, -Cl, -Br, -I, or -C6H5, -C6H4-CH3, -C6H4-OH, -C6H4-NO7, or -C6H4-NH2;

R77, R78, R79, R80 and R81 are respectively and independently selected from -H, -CH3, -CH2CH3, -OH, -OCH3, -OCH2CH3, -NO7, -CN, -COOH, -COOCH3, -COOCH7CH3, -F, -Cl, -Br, -I, -CF3, -CC13, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, or -N(CH2CH2OH)2;

R85, R86 and R87 are respectively and independently selected from -H, -CH3, -CH2CH3, -OH or -NH2; R'85, R'86 and R'87 are respectively and independently selected from -H, -CH3, -CH2CH3, -C6H5, or -CH2C6H4;

Q is selected from N, O or S;

R88, R89, R90, R'88, R'89 and R'90 are respectively and independently selected from -H, -CH2CH3, -OH, -OCH3,-OCH2CH3, -NO2, -NH2,-NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -CN, -COOH, -COOCH3, or -COOCH2CH3;

R94, R95, R'94 and R'95 are respectively and independently selected from -H, -CH3, -CH2CH3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -F, -Cl, -Br, -I, or -NHCOCH3, NHCOCH2CH3, or NHCOC6H5;

R96 is selected from -H, -CH3, -CH2CH3, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH7CH3)2, -NHCH2CH-)OH, or -N(CH2CH2OH)2, R'96 is selected from -H, -CH3, -CH2CH3, -C6H5, or -CH2C6H4;

R m1, R m2, R m3, R'm1, R,'m2 and R'm3 are respectively and independently selected from -H, -CH3, -CH2CH3, -F, -Cl, -Br, -I, -OH, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, or -NHC6H5;

R b1, R b2, R b3 and R b4 are respectively and independently selected from -H, -CH3, -CH2CH3, -CH2OH, -OH, -OCH3, -OCH2CH3, -CN, -NO2, -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -F, -Cl, -Br, or -I;

R mz1 is selected from -H, -CH3, -CH2CH3, -CH2CH2OH, -C6H5, or -CH2C6H5; R mz2 and R mz3 are respectively and independently selected from -H, -CH3, -CH2CH3, -OCH3, -CH2OH, -NO2 or -NH2, -NHCH3, -N(CH3)2, -NHCH2CH3, -N(CH2CH3)2, -NHCH2CH2OH, -N(CH2CH2OH)2, -CONH2, or -COOH;

R p11 and R p12 are respectively and independently selected from -H, -CH3, -CH2CH3, -OH, -OCH3, -OCH2CH3, F, Cl, Br, or I; R p13 is selected from -H, -CH3, -CH2CH3, -CH2CH2OH, -C6H5, or -CH2C6H5.
2. The benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof according to claim 1, wherein X represents monosubstituted or polysubstitued or unsubstituted alkoxy, monosubstituted or polysubstitued or unsubstituted alkyl, monosubstituted or polysubstituted or unsubstituted alkenyl, monosubstituted or bisubstituted or unsubstituted thienyl, monosubstituted or bisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstituted pyridazinyl, monosubstituted or bisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or unsubstituted pyrazinyl, monosubstituted or bisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted phenyl, monosubstituted or bisubstituted or unsubstituted pyrimidinyl, monosubstituted or bisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or unsubstituted quinolinyl, monosubstituted or bisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or unsubstituted indolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrazolyl.
3. The benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof according to claim 2, wherein X represents C1-C6 alkyloxy substituted by nitro, amino, hydroxyl or aryl; , C1-C6 alkyl substituted by nitro, amino, hydroxyl or aryl;
C2-C14 alkenyl substituted by alkyl, hydroxyl or aryl; thienyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted thienyl; pyidyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted pyridyl; quinolinyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted quinolinyl; indolyl monosubstituted by nitro, amino or C1-C6 alkyl;
unsubstituted indolyl; pyridyl monosubstituted or bisubstituted by C1-C6 alkoxy; pyridyl monosubstituted or bisubstituted by C1-C3 dialkylamino; pyridyl monosubstituted or bisubstituted by C1-C6 alkyl; unsubstituted pyridyl; pyridazinyl monosubstituted by C1-C6 alkoxy; pyridazinyl monosubstituted by C1-C6 alkyl; unsubstituted pyridazinyl;

unsubstituted piperazinyl; piperazinyl bisubstituted by C1-C6 alkyl;
unsubstituted piperidinyl; unsubstituted pyrazinyl; unsubstituted thiazolyl; imidazolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted imidazolyl; thiazolyl bisubstituted by C1-C6 alkyl and nitro; unsubstituted pyrimidinyl; pyrimidinyl monosubstituted by phenyl;
pyrimidinyl bisubstituted by amino and a group selected from nitro, -F, -Cl, -Br or -I;
phenyl trisubstituted by trihydroxyl; phenyl trisubstituted by trimethoxyl;
phenyl bisubstituted by hydroxyl and methoxyl; imidazolyl substituted by a group selected from methyl, ethyl, carboxyl or amido; pyrazolyl bisubstituted or trisubstituted by a group selected from C1-C6 alkyl or aryl and a group selected from -F, -Cl, -Br or -I.
4. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof according to claim 1, wherein, Y represents hydroxyl, C1-C6 alkyl, monosubstituted or bisubstituted or trisubstituted phenyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstitued pyrazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzpyrimidinyl, monosubstituted or bisubstituted or trisubstituted or tetrasubstituted or unsubstituted benzimidazolyi, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzimidazolonyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted purinyl.
5. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof according to claim 4, wherein, Y represents hydroxymethyl, hydroxyethyl, aminophenyl, hydroxyphenyl, C1-C6 alkylphenyl, phenyl monosubstituted by -F, -Cl, -Br or -I, phenyl bisubstituted by hydroxyl and carboxyl, hydroxyethyl bisubstituted by hydroxylmethyl or C1-C6 alkyl and monosubstituted phenyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, pyridyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, pyrazinyl monosubstituted or bisubstituted or unsubstituted, by C1-C6 alkyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, pyrrolyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C1-C6 alkyl, thiazolyl monosubstituted by C1-C6 alkyl, pyrimidinyl monosubstituted or bisubstituted or unsubstituted by C1-C6 alkyl, pyrimidinyl monsubstituted by C1-C6 alkyl and bisubstituted by hydroxyl, pyrimidinyl monosubstituted C1-C6 alkyl and bisubstituted or trisubstituted by -F, -Cl, -Br or -1, purinyl monosubstituted or bisubstituted or unsubstituted by C1-C6 alkyl, purinyl monosubstituted by C1-C6 alky and substituted or trisuvstituted by hydroxyl.
6. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof according to claim 1, wherein, the derivatives are as follows:
(1)(L)-2-(5-nitro-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide (2)(L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide (3)(L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (4)2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxy ethyl)]amide (5)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (6)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-chlorophenyl)amide (7)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-bromophenyl)amide (8)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (9)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-chlorophenyl)amide (10)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-bromophenyl)amide (11)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (12)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-chlorophenyl)amide (13)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-bromophenyl)amide (14)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-methylphenyl)amide (15)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-hydroxylphenyl)amide (16)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (17)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-methylphenyl)amide (18)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-hydroxylphenyl)amide (19)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (20)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-methylphenyl)amide (21)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-hydroxylphenyl)amide (22)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (23)(L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylh ydroxyethyl)]amide (24)(L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (25)2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyeth yl)]amide (26)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (27)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-chlorophenyl)amide (28)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-bromophenyl)amide (29)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (30)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (31)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (32)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (33)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (34)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (35)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (36)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (37)(L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylh ydroxyethyl)]amide (38)(L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (39)2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyeth yl)]amide (40)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (41)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (42)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (43)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (44)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (45)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (46)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (47)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (48)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (49)(L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (50)(L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (51)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydro xyethyl)]amide (52)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (53)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (54)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (55)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (56)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (57)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (58)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (59)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (60)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (61)(L)-2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide (62)(L)-2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (63)2-(3-pyridazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]a mide (64)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (65)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (66)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (67)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (68)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (69)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (70)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (71)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (72)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (73)(L)-2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (74)(L)-2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (75)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorop henylhydroxyethyl)]amide (76)2-(2-N-methyl-4-N-methyl piperazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (77)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (78)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (79)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (80)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (81)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (82)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (83)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (84)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (85)(L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydrox yethyl)]amide (86)(L)-2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (87)2-(2-pyrazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (88)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (89)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (90)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (91)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (92)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (93)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (94)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (95)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (96)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (97)(L)-2-N-piperazinyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydrox yethyl)]amide (98)(L)-2-N-piperazinyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (99)2-N-piperazinyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (100)2-N-piperazinyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide (101)2-N-piperazinyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide (102)2-N-piperazinyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide (103)2-N-piperazinyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (104)2-N-piperazinyl-1H-benzimidazole-4-(N-o-aminophenyl)amide (105)2-N-piperazinyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (106)2-N-piperazinyl-1H-benzimidazole-4-(N-m-aminophenyl)amide (107)2-N-piperazinyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (108)2-N-piperazinyl-1H-benzimidazole-4-(N-p-aminophenyl)amide (109)(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nit rophenylhydroxyethyl)]amide (110)(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-ami nophenylhydroxyethyl)]amide (111)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylh ydroxyethyl)]amide (112)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (113)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (114)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (115)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (116)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (117)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (118)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (119)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (120)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (121)(L)-2-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (122)(L)-2-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxye thyl)]amide (123)2-thiazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (124)2-thiazolyl-1H-benzimidazole-4-(N-o-fluorophenyl)amide (125)2-thiazolyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide (126)2-thiazolyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide (127)2-thiazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (128)2-thiazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide (129)2-thiazolyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (130)2-thiazolyl-1H-benzimidazole-4-(N-m-aminophenyl)amide (131)2-thiazolyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (132)2-thiazolyl-1H-benzimidazole-4-(N-p-aminophenyl)amide (133)(L)-5-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (134)(L)-5-thiazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxye thyl)]amide (135)5-thiazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (136)5-thiazolyl-1H-benzim idazole-4-(N-o-fluorophenyl)amide (137)5-thiazolyl-1H-benzimidazole-4-(N-m-fluorophenyl)amide (138)5-thiazolyl-1H-benzimidazole-4-(N-p-fluorophenyl)amide (139)5-thiazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (140)5-thiazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide (141)5-thiazolyl-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (142)5-thiazolyl-1H-benzimidazole-4-(N-m-aminophenyl)amide (143)5-thiazolyl-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (144)5-thiazolyl-1H-benzimidazole-4-(N-p-aminophenyl)amide (145)(L)-2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (146)(L)-2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (147)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydro xyethyl)]amide (148)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (149)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (150)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)am ide (151)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (152)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (153)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (154)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (155)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (156)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (157)(L)-2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (158)(L)-2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (159)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydro xyethyl)]amide (160)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (161)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (162)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (163)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (164)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (165)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (166)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (167)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (168)2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (169)(L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (170)(L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhy droxyethyl)]amide (171)2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (172)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (173)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (174)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (175)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (176)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (177) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (178)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (179)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (180)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (181)(L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (182)(L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (183)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydr oxyethyl)]amide (184)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (185)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (186)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (187)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (188)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (189)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (190)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (191)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (192)2-(2- phenyl-5-pyrimidinyl)-] H-benzimidazole-4-(N-p-aminophenyl)amide (193)(L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2 -p-nitrophenylhydroxyethyl)]amide (194)(L)-2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2 -p-aminophenylhydroxyethyl)]amide (195)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophe nylhydroxyethyl)]amide (196)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (197)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (198)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (199)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (200)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (201)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (202)2-(4-amino-6-chloro-5-pyrimidinyl)-1H -benzimidazole-4-(N-m-aminophenyl)amide (203)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (204)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (205)(L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (206)(L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (207)2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (208)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (209)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (210)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (211)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (212)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (213)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (214)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (215)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (216)(L)-2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophe nylhydroxyethyl)]amide (217)(L)-2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminoph enylhydroxyethyl)]amide (218)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxy ethyl)]amide (219)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (220)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (221)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (222)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (223)2-(N-methyl -2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (224)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (225)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (226)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (227)(L)-2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (228)(L)-2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (229)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydr oxyethyl)]amide (230)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (231)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (232)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (233)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (234)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (235)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (236)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (237)2-(3, 5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)am ide (23 8)(L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide (239)(L)-2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (240)2{2-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (241)2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (242)2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (243)2-(2-quinolinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (244)2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)am ide (245)2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (246)2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (247)2-(2-quinolinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (248)2-(2-quinolinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (249)(L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide (250)(L)-2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (251)2-(3-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]a mide (252)2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (253)2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (254)2-(3-quinolinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (25 5)2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (256)2-(3-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (257)2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (258)2-(3-quinolinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (259)2-(3-quinolinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (260)(L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (26 1)(L)-2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide (262)2-(2-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (263)2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (264)2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (265)2-(2-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (266)2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (267)2-(2-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (268)2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (269)2-(2-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (270)2-(2-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (271)(L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (272)(L)-2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide (273)2-(3-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (274)2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (275)2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (276)2-(3-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (277)2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (278)2-(3-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (279)2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (280)2-(3-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (281)2-(3-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (2 82)(L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (283)(L)-2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide (284)2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (285)2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (286)2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (287)2-(4-piperidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (288)2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (289)2-(4-piperidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (290)2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (291)2-(4-piperidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (292)2-(4-piperidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (293)(L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (294)(L)-2-(3-indolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydrox yethyl)]amide (295)2-(3-indolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (296)2-(3-indolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (297)2-(3-indolyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (298)2-(3-indolyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (299)2-(3-indolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (300)2-(3-indolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (301)2-(3-indolyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (302)2-(3-indolyl)-1H-benzim idazole-4-(N-m-aminophenyl)amide (303)2-(3-indolyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (304)(L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (305)(L)-2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (306)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydr oxyethyl)]amide (307)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (308)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (309)2-(2, 3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (310)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (311)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (312)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (313)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (314)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (315)(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (316)(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (317)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chloropheny 1hydroxyethyl)]amide (318)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (319)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (320)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (321)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (322)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (323)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (324)2-(3 -hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (325)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (326)(L)-2-methoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (327)(L)-2-methoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxye thyl)]amide (328)2-methoxy-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (329)2-methoxy-1H-benzimidazole-4-(N-N'-piperidinyl)amide (330)2-methoxy-1H-benzimidazole-4-(N-2-piperazinyl)amide (331)2-methoxy-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (332)2-methoxy-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (333)2-methoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide (334)2-methoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (335)2-methoxy-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (336)2-methoxy-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (337)2-methoxy-1H-benzimidazole-4-(N-2-imidazolyl)amide (338)2-methoxy-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (339)2-methoxy-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (340)2-methoxy-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (341)2-methoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide (342)2-methoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (343)2-methoxy-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (344)2-methoxy-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (345)2-methoxy-1H-benzimidazole-4-(N-2-pyridyl)amide (346)2-methoxy-1H-benzimidazole-4-(N-3-pyridyl)amide (347)2-methoxy-1H-benzimidazole-4-(N-4-pyridyl)amide (348)2-methoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (349)2-methoxy-1H-benzimidazole-4-(N-5-thiazolyl)amide (3 50)2-methoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (351)2-methoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (352)2-methoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (353 )2-methoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (354)(L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl )]amide (355)(L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyeth yl)]amide (356)2-ethoxy-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (357)2-ethoxy-1H-benzimidazole-4-(N-N'-piperidinyl)amide (358)2-ethoxy-1H-benzimidazole-4-(N-2-piperazinyl)am ide (359)2-ethoxy-1H-benzimidazole-4-(N-2'-benzimidazolyl)am ide (360)2-ethoxy-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (361)2-ethoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide (362)2-ethoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (363)2-ethoxy-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (364)2-ethoxy-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (365)2-ethoxy-1H-benzimidazole-4-(N-2-imidazolyl)amide (366)2-ethoxy-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (367)2-ethoxy-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (368)2-ethoxy-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (369)2-ethoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide (370)2-ethoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (371)2-ethoxy-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (372)2-ethoxy-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (373)2-ethoxy-1H-benzimidazole-4-(N-2-pyridyl)amide (374)2-ethoxy-1H-benzimidazole-4-(N-3-pyridyl)amide (375)2-ethoxy-1H-benzimidazole-4-(N-4-pyridyl)amide (376)2-ethoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (377)2-ethoxy-1H-benzimidazole-4-(N-5-thiazolyl)amide (378)2-ethoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (379)2-ethoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (380)2-ethoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (381)2-ethoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (382)(L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-ni trophenylhydroxyethyl)]amide (383)(L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-a minophenylhydroxyethyl)]amide (384)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide (385)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (386)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (387)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (388)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (389)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (390)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (391)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazol yl)amide (392)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4'-carboxyl-5' -imidazolyl)amide (393)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (394)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (395)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (396)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (397)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (398)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (399)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (400)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (401)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (402)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (403)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (404)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (405)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (406)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (407)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (408)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidi nyl)amide (409)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (410)(L)-2-pyrazolyl-1H-benzimidazole-4-[N{ 1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (411)(L)2-pyrazolyl-1H-benzimidazole-4-[N{1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (412) 2-pyrazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (413) 2-pyrazolyl-1H-benzimidazole-4-(N-N'-piperidinyl)amide (414) 2-pyrazolyl-1H-benzimidazole-4-(N-2-piperazinyl)amide (415) 2-pyrazolyl-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (416) 2-pyrazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (417) 2-pyrazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide (418) 2-pyrazolyl-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (419) 2-pyrazolyl-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (420) 2-pyrazolyl-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (421) 2-pyrazolyl-1H-benzimidazole-4-(N-2-imidazolyl)amide (422) 2-pyrazolyl-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (423) 2-pyrzazolyl-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (424) 2-pyrazolyl-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (425) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrazinyl)amide (426) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (427) 2-pyrazolyl-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (428) 2-pyrazolyl-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (429) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyridyl)amide (430) 2-pyrazolyl-1H-benzimidazole-4-(N-3-pyridyl)amide (431) 2-pyrazolyl-1H-benzimidazole-4-(N-4-pyridyl)amide (432) 2-pyrazolyi-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (433) 2-pyrazolyl-1H-benzimidazole-4-(N-5-thiazolyl)amide (434) 2-pyrazolyl-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (435) 2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (436) 2-pyrazolyl-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (437) 2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (438)(L)-2-(2'-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (439)(L)-2-(2'-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (440)2-(2'-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (441) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (442) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (443) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (444) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (445) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (446) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (447) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (448) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (449) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (450) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (451) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (452) 2-(2'-pyridyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (453) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (454) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (455) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (456) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (457) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (458) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (459) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (460) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (461)2-(2'-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (462)2-(2'-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (463)2-(2'-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (464)2-(2'-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (465)2-(2'-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (466)(LY243'-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (467)(L)-2-(3'-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (468)2-(3'-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (469)2-(3'-pyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (470)2-(3'-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (471)2-(3'-pyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (472)2-(3'-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (473 )2-(3'-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (474)2-(3'-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (475 )2-(3'-pyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (476)2-(3'-pyridyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (477)2-(3'-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (478)2-(3'-pyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (479)2-(3'-pyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (480)2-(3'-pyridyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (481)2-(3'-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (482)2-(3'-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (483)2-(3'-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (484)2-(3'-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (485)2-(3'-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (486)2-(3'-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (487)2-(3'-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (488)2-(3'-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (489)2-(3'-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (490)2-(3'-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (491)2-(3'-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (492)2-(3'-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (493)2-(3'-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (494)(L)-244'-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (495)(L)-2-(4'-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (496)2-(4'-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (497)2-(4'-pyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (498)2-(4'-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (499)2-(4'-pyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (500)2-(4'-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (501)2-(4'-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (502)2-(4'-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (503)2-(4'-pyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (504)2-(4'-pyridyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (505)2-(4'-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (506)2-(4'-pyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (507)2-(4'-pyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (508)2-(4'-pyridyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (509)2-(4'-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (510)2-(4'-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (511)2-(4'-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (512)2-(4'-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (513)2-(4'-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (514)2-(4'-pyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (515 )2-(4'-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (516)2-(4'-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (517)2-(4'-pyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (518)2-(4'-pyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (519)2-(4'-pyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (520)2-(4'-pyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (521)2-(4'-pyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (522)(L)-2-(2'-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (523)(L)-2-(2'-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhy droxyethyl)]amide (524)2-(2'-imidazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (525)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (526)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (527)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (528)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (529)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (530)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (531)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (532)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (533)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (534)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (535)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (536)2-(2'-imidazolyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (537)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (538)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (539)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (540)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (541)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (542)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (543)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (544)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (545)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (546)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (547)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (548)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (549)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (550)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (551)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (552)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (553)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (554)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (555)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (556)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (557)2-(4-methoxypyridyl)-I H-benzimidazole-4-(N-4'-pyrazolyl)amide (558)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (559)2-(4-methoxypyridyl)1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (560)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (561)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (562)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (563)2-(4-methoxypyridyl)1H-benzimidazole-4-(N-5-pyrimidinyl)amide (564)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (565)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (566)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (567)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (568)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (569)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (570)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (571)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (572)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (573)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (574)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (575)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (576)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (577)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (578)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (579)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (580)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (581 )2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (582)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (583)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (584)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (585)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (586)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (587)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (588)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (589)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (590)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (591)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (592)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (593)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (594)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (595)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (596)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (597)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (598)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (599)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (600)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (601)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (602)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (603)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (604)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (605)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N'-ethyl-N -piperazinyl)amide (606)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (607)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (608)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (609)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (610)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (611)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (612)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (613)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (614)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (615)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (616)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (617)244-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (618)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (619)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (620)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (621)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (622)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (623)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (624)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (625)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (626)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (627)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (628)2-(3-pyridazinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (629)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (630)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (631)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (632)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (633)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (634)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (635)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (636)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (637)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (638)2-(3-pyridazinyl)-l H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (639)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (640)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (641)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (642)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (643)2-(2-N-methyl-4- N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (644)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (645)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (646)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imid azolyl)amide (647)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazol yl)amide (648)2-(2 N-methyl-4-N-methylpiperazinyl)1H-benzimidazole-4-(N-2-imidazolyl)amide (649)2-(2-N-methyl-4-N-methylpiperazinyl)1H-benzimidazole-4-(N-4'-pyrazolyl)amide (650)2-(2 N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (651)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (652)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (653)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (654)2-(2 N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (655)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (656)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (657)2-(2 N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (658)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (659)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (660)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (661)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimi dinyl)amide (662)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimi dinyl)amide (663)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyri midinyl)amide (664)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidi nyl)amide (665)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (666)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (667)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (668)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (669)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (670)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (671)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (672)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (673)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (674)2-(2-pyrazinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (675)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (676)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (677)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (678)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (679)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (680)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (681)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (682)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (683)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (684)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (685)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (686)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (687)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (688)2-(2-piperazinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (689)2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (690)2-(2-piperazinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (691)2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (692)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (693)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (694)2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (695)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (696)2-(2-piperazinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (697)2-(2-piperazinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (698)2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (699)2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (700)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (701)2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (702)2-(2-piperazinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (703)2-(2-piperazinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (704)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (705)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (706)2-(2-piperazinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (707)2-(2-piperazinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (708)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (709)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (710)2-(2-piperazinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (711)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (712)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (713 )2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (714)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (715)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (716)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (717)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (718)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (719)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (720)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (721)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (722)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (723)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (724)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (725)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (726)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (727)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (728)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (729)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (730)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (731)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (732)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidi nyl)amide (733)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (734)2-(2-thiazolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (735)2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (736)2-(2-thiazolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (737)2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (738)2-(2-thiazolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (739)2-(2-thiazolyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (740)2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (741)2-(2-thiazolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (742)2-(2-thiazolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (743)2-(2-thiazolyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (744)2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (745)2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (746)2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (747)2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (748)2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (749)2-(2-thiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (750)2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (751)2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (752)2-(2-thiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (753)2-(2-thiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (754)2-(2-thiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (755)2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (756)2-(2-thiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (757)2-(5-thiazolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (758)2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (759)2-(5-thiazolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (760)2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (761)2-(5-thiazolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (762)2-(5-thiazolyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (763)2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (764)2-(5-thiazolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (765)2-(5-thiazolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (766)2-(5-thiazolyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (767)2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (768)2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (769)2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (770)2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (771)2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (772)2-(5-thiazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (773)2-(2-thiazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (774)2-(5 thiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (775)2-(5-thiazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (776)2-(5-thiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (777)2-(5-thiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (778)2-(5-thiazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (779)2-(5-thiazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (780)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (781)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (782)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (783)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (784)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (785)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (786)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (787)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (788)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (789)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (790)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (791)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (792)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (793)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (794)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (795)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (796)2-(2- pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (797)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (798)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (799)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (800)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (801)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (802)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (803)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (804)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (805)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (806)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (807)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (808)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (809)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (810)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (811)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (812)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (813)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (814)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (815)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (816)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (817)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (818)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (819)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (820)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (821)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (822)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (823)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (824)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (825)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (826)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (827)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (828)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (829)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (830)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidaz olyl)amide (831)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N4'-carboxyl-5'-imidazolyl)amide (832)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (833)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (834)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (835)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (836)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (837)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (838)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (839)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (840)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (841)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (842)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (843)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (844)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (845)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidi nyl)amide (846)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidin yl)amide (847)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimi dinyl)amide (848)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl )amide (849)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (850)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (851)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (852)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (853)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (854)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (855)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (856)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (857)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (85 8)2-(2-pyrrolyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (859)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (860)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (861)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (862)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (863)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (864)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (865)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (866)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (867)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (868)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (869)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (870)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (871)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (872)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (873)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide ( 874)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (875)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (876)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (877)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (878)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (879)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (880)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (881)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (882)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (883)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (884)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (885)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (886)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (887)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (888)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (889)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (890)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (891)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (892)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (893)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (894)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (895)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (896)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (897)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (898)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (899)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (900)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (901)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (902)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (903)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (904)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (905)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (906)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (907)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (908)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (909)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (910)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (911)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (912)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (913)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (914)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (915)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (916)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (917)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (918)2-(2-quinolinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (919)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (920)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (921)2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (922)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (923)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (924)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (925)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (926)2-(2-quinolinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (927)2-(2-quinolinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (928)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (929)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (930)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (931)2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (932)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (933)2-(2-quinolinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (934)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (935)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (936)2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (937)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (93 8)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (939)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (940)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (941)2-(2-piperidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (942)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (943)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (944)2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (945)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (946)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (947)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (948)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4' -pyrazolyl)amide (949)2-(2-piperidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (950)2-(2-piperidinyl)-1H-benzimidazole-4-(N'-ethyl-N -piperazinyl)amide (951)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (952)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (953)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (954)2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (955)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (956)2-(2-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (957)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (958)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (959)2-(2-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (960)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (961)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (962)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (963)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (964)2-(3-piperidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (965)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (966)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (967)2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (968)2-(3-piperidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (969)2-(3-piperidinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (970)2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (971)2-(3-piperidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (972)2-(3-piperidinyl)-1H-benzimidazole-4-(N-(N' -piperazinyl))amide (973)2-(3-piperidinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (974)2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (975)2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (976)2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (977)2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (978)2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (979)2-(3-piperidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (980)2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (981)2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (982)2-(3-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (983)2-(3-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (984)2-(3-piperidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (985)2-(3-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (986)2-(3-piperidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (987)2-(4-piperidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (988)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (989)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (990)2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (991)2-(4-piperidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (992)2-(4-piperidinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (993)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (994)2-(4-piperidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (995)2-(4-piperidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (996)2-(4-piperidinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (997)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (998)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (999)2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide ( 1000)2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1001)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (1002)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (1003)2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (1004)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1005)2-(4-piperidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (1006)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1007)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)am ide (1008)2-(4-piperidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1009)2-(4-piperidinyl)-1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1010)2-(3-indolyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (1011)2-(3-indolyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (1012)2-(3-indolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1013)2-(3-indolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1014)2-(3-indolyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (1015)2-(3-indolyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (1016)2-(3-indolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (1017)2-(3-indolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (1018)2-(3-indolyl)- 1H-benzimidazole-4-(N-(N '-piperazinyl))amide (1019)2-(3-indolyl)-1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1020)2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (1021)2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1022)2-(3-indolyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1023)2-(3-indolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1024)2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (1025)2-(3-indolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (1026)2-(3-indolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (1027)2-(3-indolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1028)2-(3-indolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (1029)2-(3-indolyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1030)2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (1031)2-(3-indolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1032)2-(3-indolyl)- 1H-benzimidazole-4-(N-4, 6-dichloro-5-pyrimidinyl)amide (1033)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (1034)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-piperazinyl))amide (1035)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1036)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1037)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (1038)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4'-carboxyl-5 '-imidazolyl)amide (1039)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (1040)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (1041)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (1042)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1043)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (1044)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1045)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1046)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1047)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (1048)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (1049)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (1050)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1051)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (1052)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1053)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (1054)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1055)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1056)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-N' -piperidinyl)amide (1057)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (1058)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1059)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1060)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazol yl)amide (1061)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (1062)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (1063)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N -4 '-pyrazolyl)amide (1064)2-(3-hydroxyl-4-methoxtphenyl)- 1H-benzimidazole-4-(N-(N ' -piperazinyl))amide (1065)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1066)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (1067)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1068)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1069)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1070)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (1071)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (1072)2-(3-hydroxyl-4-methoxyphenyl)-1 H-benzimidazole-4-(N-4-pyridyl)amide (1073)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1074)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-5 -thiazolyl )amide (1075)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidin yl)amide (1076)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidiny 1)amide (1077)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimid inyl)amide (1078)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1079)(L)-2-(2-bromo-5-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhy droxyethyl)]amide (1080)(L)-2-(2-bromo-5-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylh ydroxyethyl)]amide (1081)2-(2-bromo-5-pyridine)-1H-benzimidazole4-[N-( 1-methyl-2-p-chlorophenylhydroxyethyl)]amide (1082)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (1083)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-piperazinyl))amide (1084)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1085)242-bromo-5-pyridine)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1086)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-o-aminophenyl)amide (1087)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1088)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4'-carbonam ido-5'-imidazolyl)amide (1089)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4'-carboxyl-5' -imidazolyl)amide (1090)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-imidazolyl)amide (1091)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (1092)2-(2-bromo-5-pyridine)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (1093)2-(2-bromo-5-pyridine)-1H-benzim idazole-4-(N'-ethyl-N-piperazinyl)amide (1094)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (1095)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1096)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1097)2-(2-bromo-5-pyridine)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1098)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-pyridyl)amide (1099)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-3-pyridyl)amide (1100)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-pyridyl)amide (1101)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1102)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-5-thiazolyl)amide (1103)2-(2-bromo-5-pyridine)-l H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1104)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4,6-di(2-bromo-5-pyridine)-2-pyrim i dinyl)amide (1105)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1106)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1107)(L)-2-(2-am ino-3-pyridine)-1H-benzimidazole-4-[N-( 1 -hydroxymethyl-2-p-nitrophenylhy droxyethyl)]amide (1108)(L)-2-(2-amino-3-pyridine)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylh ydroxyethyl)]amide (1109)2{2-amino-3-pyridine) 1H-benzimidazole4-[N-( 1 -methyl-2-p-chlorophenylhydroxyethyl)]amide (1110)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (1111)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-piperazinyl))amide (1112)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1113)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1114)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-o-aminophenyl)amide (1115)2-(2-amino-3-pyridine) 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1116)2-(2-amino-3-pyridine) 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)am ide (1117)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (1118)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-imidazolyl)amide (1119)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4' -pyrazolyI)amide (1120)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-(N '-piperazinyl))amide (1121)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1122)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (1123)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1124)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1125)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1126)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-pyridyl)amide (1127)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-3-pyridyl)amide (1128)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-pyridyl)amide (1129)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1130)2-(2-amino-3-pyridine)-] H-benzimidazole-4-(N-5-thiazolyl)amide (1131)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1132)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4,6-di(2-amino-3-pyridine)-2-pyrimid inyl)amide (11 33)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1134)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1135)(L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (1136)(L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (1137)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chloropheny lhydroxyethyl)]amide (1138)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (1139)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (1140)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1141)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1142)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (1143)2-(2-pyrrolidine-1 -yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1144)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imida zolyl)amide (1145)2{2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (1146)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (1147)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (1148)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (1149)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1150)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (1151 )2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1152)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1153)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1154)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (1155)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (1156)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyridyl)amide (1157)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1158)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (1159)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimid inyl)amide (1160)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6-di(2-pyrrolidine-1-yl-5 -pyrimidinyl)-2-pyrimidinyl)amide (1161)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyri midinyl)amide (1162)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidin yl)amide (1163)(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(]-hydroxymethyl-2-p-n itrophenylhydroxyethyl)]amide (1164)(L)-2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-ami nophenylhydroxyethyl)]amide (1165)2-(2-piperidine-1 -yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhy droxyethyl)]amide (1166)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (1167)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (1168)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1169)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1170)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (1171)2-(2-piperidine- 1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1172)2-(2-piperidine-1 -yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidaz olyl)amide (1173)2-(2-piperidine-1-yl-5-pyrimidinyl) 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (1174)2-(2-piperidine-1 - yl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2-imidazolyl)amide (1175)2-(2-piperidine-1- yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (1176)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (1177)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1178)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (1179)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1180)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1181)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1182)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (1183)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (1184)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (1185)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1186)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(5-thiazolyl)amide (1187)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidi nyl)amide (1188)2-(2-piperidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4,6-di(2-piperidine-1-yl-5-pyrimidinyl)-2-pyrimidinyl)amide (1189)2-(2-piperidine-1 -yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrim idinyl)amide (1190)2-(2-piperidine-1-yl-5-pyrimidinyl) 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1191)(L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (1192)(L)-2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (1193)2-(2-cyclopropylamino-5-pyrimidinyl)-1 H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide (1194)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (1195)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (1196)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1197)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1198)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (1199)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1200)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imi dazolyl)amide (1201)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazo lyl)amide (1202)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (1203)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (1204)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (1205)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1206)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (1207)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1208)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1209)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1210)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (1211)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (1212)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (1213)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1214)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(5-thiazolyl)amide (1215)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrim idinyl)amide (1216)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-di(2-cyclopropylam ino-5-pyrimidinyl)-2-pyrimidinyl)amide (1217)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-py rimidinyl)amide (1218)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidi nyl)amide (1219)(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (1220)(L)-2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-a minophenylhydroxyethyl)]amide (1221)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenyl hydroxyethyl)]amide (1222)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (1223)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide (1224)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1225)2-(1,3-dimethyl-5-chloro4-pyrazolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1226)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (1227)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1228)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imid azolyl)amide (1229)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4' -carboxyl-5' -imidazol yl)amide (1230)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (1231)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (1232)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (1233)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1234)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (1235)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1236)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1237)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1238)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (1239)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-3-pyridyl)amide (1240)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (1241)2{1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1242)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(5-thiazolyl)amide (1243)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrim idinyl)amide (1244)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimi dinyl)amide (1245)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyr imidinyl)amide (1246)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidi nyl)amide (1247)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1248)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1249)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1250)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1251)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1252)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1253)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1254)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1255)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1256)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1257)2-(4-dimethylam inopyridyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1258)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1259)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1260)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1261)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1262)2-(2-N-methyl-4-N-methyl piperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrim idinyl)amide (1263)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1264)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole4{N-6-hydroxyl-2-purinyl)amide (1265)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1266)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1267)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1268)2-N-piperazinyl-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1269)2-N-piperazinyl-1H-benzimidazole-4-(N-6-purinyl)amide (1270)2-N-piperazinyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1271)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1272)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1273)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1274)2-thiazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1275)2-thiazolylI-1H-benzimidazole-4-(N-6-purinyl)amide (1276)2-thiazolyl-1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1277)5-thiazolyl- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1278)5-thiazolyl-1H-benzimidazole-4-(N-6-purinyl)amide (1279)5-thiazolyl-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1280)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1281)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1282)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1283)2-(2-phenyl-5-pyrimidinyl)-1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (I 284)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1285)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1286)2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1287)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1288)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1289)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1290)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1291)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1292)2-(N-methyl -2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1293)2-(N-methyl-2-pyrrolyl )- 1H-benzimidazole-4-(N-6-purinyl)amide (1294)2-(N-methyl-2-pyrrolyl )-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1295)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1296)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1297)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1298)2-(2-quinolinyl)-1 H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1299)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1300)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1301)2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1302)2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1303)2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1304)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1305)2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1306)2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1307)2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1308)2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1309)2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1310)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1311)2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1312)2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1313)2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1314)2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1315)2-(3-indolyl)-1H-benzim idazole-4-(N-6-hydroxyl-2-purinyl)amide (1316)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1317)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1318)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1319)2-(3-hydroxyl4-methoxyphenyl)- 1H-benzimidazole-4-(N-2-hydroxyl4-pyrimidinyl)amide (1320)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzim idazole-4-(N-6-purinyl)amide (1321)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1322)2-methoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1323)2-methoxy-1H-benzimidazole-4-(N-6-purinyl)amide (1324)2-methoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1325)2-ethoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1326)2-ethoxy-1H-benzimidazole-4-(N-6-purinyl)amide (1327)2-ethoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1328)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1329)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1330)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1331)2-pyrazolyl-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1332)2- pyrazolyl -1 H-benzimidazole-4-(N-6-purinyl)amide (1333)2- pyrazolyl -1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1334)2-(2'-pyridyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1335)2-(2'-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1336)2-(2'-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1337)2-(3'-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1338)2-(3'-pyridyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1339)2-(3'-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1340)2-(4'-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1341)2-(4'-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1342)2-(4'-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1343)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1344)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1345)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1346)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1347)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1348)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1349)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1350)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide;
(1351)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1352)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1353)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1354)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1355)2-(2-N-methyl -4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrim idinyl)amide (1356)2-(2-N-methyl -4-N-methyl piperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1357)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4{N-6-hydroxyl-2-purinyl)amide (1358)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1359)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1360)2-(2-pyrazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1361)244-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1362)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1363)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1364)2-(2-thiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1365)2-(2-thiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1366)2-(2-thiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1367)2-(5-thiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1368)2-(5-thiazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1369)2-(5-thiazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1370)2-(2-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1371)2-(2-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1372)2-(2-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1373)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1374)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1375)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1376)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1377)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1378)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1379)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1380)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1381)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1382)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1383)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1384)2-(N-methyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1385)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1386)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1387)2(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1388)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1389)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1390)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1391)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1392)2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1393)2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1394)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1395)2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1396)2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1397)2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1398)2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1399)2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1400)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1401)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1402)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1403)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl4-pyrimidinyl)amide (1404)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1405)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1406)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1407)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-6-purinyl)amide (1408)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1409)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1410)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-6-purinyl)amide (1411)2-(2-amino-3-pyridine)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1412)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1413)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1414)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1415)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidin yl)amide (1416)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1417)2(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1418)2-(2-cyclopropylamino)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1419)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1420)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1421)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimi dinyl)amide (1422)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1423)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1424)2(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide.
7. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to any one of claims 1 to 6, wherein the pharmaceutically acceptable salts of benzimidazole-4-carboxamide derivatives are inorganic acid salts thereof selected from sulfate, hydrochloride, nitrate, phosphate or boratethe, or organic acid salts thereof selected from citrate, succinate, tartrate, lactate or mesylate.
8. A pharmaceutical composition, comprising a therapeutically effective amount of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to any one of claims 1 ~ 7, and one or more pharmaceutically acceptable thinner, excipient and/or inert carrier.
9. A use of benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to any one of claims 1~7 for preparation of antivirus medications.
10. The use according to claim 9, wherein the viruses comprising coxsackie virus, echovirus and enterovirus of Picornaviridae.
11. A method of preparing for benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof according to Formula (I) of any one of claims 1 ~
7, comprisng the following steps:

(1) 2-aminoacetyl-3-nitrobenzoic acid is undergoing reactions of ammonolysis, Hoffman degradation and reduction in turn, to produce 2,3-diamino benzoic acid.

(2) 2,3-diamino benzoic acid is condensed with aldehydes X-CHO in the presence of catalyst of cupric acetate, to produce benzimidazole-4-carboxylic acid of Formula (II).

(3) benzimidazole-4-carboxylic acid is reacted with thionyl chloride to produce acyl chloride, and then condensing the acyl chloride and an amine NH2-Y, to produce the benzimidazole-4-carboxamide derivative of Formula (I).

12. The method according to claim 11, wherein benzimidazole-4-carboxylic acid is reated with thionyl chloride at temperature of 0~80°C in a molar molecular ratio of thionyl chloride to benzimidazole-4-carboxylic acid is 1~20 times, to produce benzimidazole-4-carbonyl chloride, and then benzimidazole-4-carbonyl chloride is reacted with an amine in an organic solvent at temperature of 0~100°C to produce benzimidazole-4-carboxamide derivatives.
13. The method according to claim 12, wherein the organic solvent comprises dichloroethane, 1,1,2-trichloroethane, chloroform, tetrachloroethylene, benzene, toluene, xylene, chlorobenzene or dichlorobenzene.
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Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
WO2009158118A2 (en) 2008-05-30 2009-12-30 University Of Notre Dame Du Lac Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria
MX2011000079A (en) * 2008-07-03 2011-03-02 Sirtris Pharmaceuticals Inc Benzimidazoles and related analogs as sirtuin modulators.
CN101619058A (en) * 2009-01-08 2010-01-06 上海交通大学 Benzimidazole-4-acid amide type derivant
CN102050823A (en) * 2010-10-27 2011-05-11 华东理工大学 Synthesis and representation of guanine analogue as novel light stabilizer
CN103249763B (en) * 2010-12-01 2016-08-31 富士胶片株式会社 Thin polymer film, retardation films, polarizer, liquid crystal display and compound
JP2016511237A (en) * 2013-02-01 2016-04-14 アセチロン ファーマシューティカルズ インコーポレイテッドＡｃｅｔｙｌｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． Selective HDAC3 inhibitor
CN104072425B (en) * 2014-07-09 2016-12-07 大连理工大学 Benzimidazoles compound and application thereof
CN111606888B (en) * 2019-02-26 2023-08-18 中国药科大学 Pyrrole derivative and preparation method and application thereof
CN114044768B (en) * 2021-12-08 2023-08-22 中国药科大学 Pyrrole BET degradation agent and application thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9518552D0 (en) * 1995-09-11 1995-11-08 Fujisawa Pharmaceutical Co New heterocyclic compounds
CA2258728C (en) * 1996-06-19 2011-09-27 Rhone Poulenc Rorer Limited Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase
WO2003035065A1 (en) * 2001-10-26 2003-05-01 Aventis Pharmaceuticals Inc Benzimidazoles and analogues and their use as protein kinases inhibitors
FR2833948B1 (en) * 2001-12-21 2004-02-06 Sod Conseils Rech Applic NOVEL BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MEDICAMENTS
CN1425663A (en) * 2002-12-19 2003-06-25 上海交通大学 Process for preparing 2-pyridyl-4-carbonyl-benzimidazole derivatives
BRPI0410967A (en) * 2003-06-04 2006-07-04 Genelabs Tech Inc compounds, compositions and their uses for the treatment of virus infections of the family flaviviridae
CN1272333C (en) * 2004-11-18 2006-08-30 上海交通大学 2-pyridyl-1H-benzimidazole-4-amide derivatives
ZA200707896B (en) * 2005-03-14 2009-07-29 High Point Pharma Llc Benzazole derivatives, compositions, and methods of use as B-secretase inhibitors
US7541367B2 (en) * 2005-05-31 2009-06-02 Janssen Pharmaceutica, N.V. 3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
CN101309908A (en) * 2005-11-15 2008-11-19 艾博特公司 Substituted 1h-benzimidazole-4-carboxamides are potent parp inhibitors
WO2008100376A2 (en) * 2007-02-15 2008-08-21 Sirtris Pharmaceuticals, Inc. Truncation variants of sirt1 and methods of use thereof
US8067613B2 (en) * 2007-07-16 2011-11-29 Abbott Laboratories Benzimidazole poly(ADP ribose)polymerase inhibitors
CN101434601B (en) * 2008-07-24 2010-09-29 上海交通大学 2-furyl-1H-benzimidazole-4-acidamide type derivative
JP2011529903A (en) * 2008-07-30 2011-12-15 オンコセラピー・サイエンス株式会社 Benzimidazole derivatives and glycogen synthase kinase 3β inhibitors containing the same
CN101353326A (en) * 2008-09-11 2009-01-28 上海交通大学 2-hydroxy phenyl-1H-benzimidazole-4-acidamide type derivates
CN101353342B (en) * 2008-09-11 2012-06-13 上海交通大学 2-pyridinyl-1H-benzimidazole-4-acidamide type derivative
CN102271514A (en) * 2008-10-30 2011-12-07 肿瘤疗法科学股份有限公司 7-Hydroxy-benzoimidazole-4-yl-methanone derivatives and PBK inhibitors containing the Same
AU2009318719A1 (en) * 2008-11-20 2011-06-30 Oncotherapy Science, Inc. Glycogen synthase kinase-3 beta inhibitors containing 7-hydroxy-benzoimidazole-4-yl-methanone derivatives
CN101619058A (en) * 2009-01-08 2010-01-06 上海交通大学 Benzimidazole-4-acid amide type derivant

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