AU2013251248A1 - Benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses - Google Patents
Benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses Download PDFInfo
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Abstract
The present invention relates to the benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses; wherein X represents monosubstituted or bissubstituted or polysubstitued C1-C 14 alkoxy, monosubstituted or bisubstituted or polysubstitued C1-C 14 alkyl, monosubstituted or bisubstituted or polysubstitued C 2-C 14 alkenyl, monosubstituted or bisubstituted or polysubstitued C6 -C 14 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom; Y represents hydrogen, monosubstituted or bisubstituted or polysubstitued C1-C16 alkyl, monosubstituted or bisubstituted or polysubstitued C6 -C 12 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom. The derivatives of the present invention have the functions of antiviral medicine. N-H
Description
1 SPECIFICATION BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION METHODS, PHARMACEUTICAL COMPOSITIONS AND THEIR USES This application is a divisional of Australian Patent Application No. 2010204407, the entire content of which is incorporated herein by reference. FIELD OF THE INVENTION The present invention relates to benzimidazole carboxamide derivatives, in particular, relates to the benzimidazole-4-carboxamide derivatives, their preparation methods, pharmaceutical compositions and their uses BACKGROUND OF THE INVENTION The diseases caused by virus infections severely threaten human health and life and have become major problems in the medical fields. Almost 70% of epidemic diseases are caused by viruses infections statistically. The infectious diseases caused by enteroviruses have often occurred all over the world. The enteroviruses belong to picornaviridae comprising polio viruses, cosxackie viruses, enteric cytopathogenic human orphan virus(ECHO) and new enteroviruses. Each viruses has many serums, at least more than 70 types, which can violate many kinds of tissues, such as nerves, cardiac muscles, muscles, skins and eye conjunctiva etc and can cause lots of infectious diseases all over the world. There are lots of categories of the cosxackie viruses, whose transmission route and pathogenesis are similar to that of poliomyelitis virus, and often occurrs latent infections. Their symptom shows slight upper respiratory infections or diarrhea, and occasionally inflects central nervous systems, damages spinal cord anterior horn motor neurons, and causes flaccid paralysis of limbs, however, this symptom is relatively light. The cosxackie viruses can violate many tissues and systems, such as respiratory tracts, intestinal tracts, skins, muscles, hearts, livers, adrenal gland and central nervous systems, Clinical manifestations have various of symptoms such as (1)respiratory tract infection, (2) herpangina, (3) febrile rush, (4) hand-foot-and-mouth disease, (5) diarrhea of children, (6) central nervous system syndrome, (7) myocarditis and pericarditis, (8) epidemic chest pain or epidemic myalgia, (9) epidemic conjunctivitis, (10) coxsackie virus hepatitis and so on.
2 SUMMARY OF THE INVENTION The purpose of the present invention is to provide benzimidazole-4-carboxamide derivatives having anti-coxsackie virusesor a pharmaceutically acceptable salts thereof as shown in Formula (I). Y N-H 0 HX (I) Wherein, X represents monosubstituted or bissubstituted or polysubstitued C 1
-C
1 4 alkoxy, monosubstituted or bisubstituted or polysubstitued C 1
-C
1 4 alkyl, monosubstituted or bisubstituted or polysubstitued C 2
-C
1 4 alkenyl, monosubstituted or bisubstituted or polysubstitued C 6
-C
1 4 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom. Y represents hydrogen, monosubstituted or bisubstituted or polysubstitued C 1
-C
16 alkyl, monosubstituted or bisubstituted or polysubstitued C 6
-C
1 2 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom. Wherein: X is selected from one of the following groups: R9R R i o R17 I R3 I N -O-R R 2 R4 R 3 '-C-C- Ri R 12 R'17 N1117 R11i8 N R' 2 4 R29 R' RN N R' 23 N N2 R2 R2 19 R"19 R2 / ,L\ R <3 3 R34 R 5R4 4.5 R N R43 Mi Rj R4 4. $N R35 pZNR 4 R36 R-41 P4 Rs 1 ' -RiRm R.Sp - R N Rm 2
R'
2 %Rs2 Rm R'mn Rk 2 Rk 2 Rk 3 RI b - Rk 1 Rp Rin 2 x R'ml N Rp2 N mN Rk 5 Rki N Rk 5 M3 Rk 6 Rk 6 Rp 4 Rp 3 Ry 1 NH Rmz Rbz N Ry \ /Rmz N Rbz Ry 3 Ry 4 Rmz 1 Rbz 3 or Rwyi Rwy 3 1 1 -( C)n-C- Rwy 5 I I Rwy 2 Rwy 4 wherein R is selected from -H, or 4 , wherein n is selected from 0 to 5, Rwy1, Rwy2, Rwys, Rwy 4 and Rwy 5 are respectively and independently selected from -H, -CH 3 , or -CH 2
CH
3 ; n=0-5; R 1 , R 2 , R 3 , R 4 and R 5 are respectively and independently selected from -H,
-CH
3 , -F, -Cl, -Br, -I, -OH, -OCH 3 , -OCH 2
CH
3 , -NO 2 , -NH-CH 3 , -NH-CH 2
CH
3 ,
-NH-CH
2
CH
2 OH, C H 3 -14 -C H 3 , C H-N -C H 2 C H, C H -1-CH 2CH 0H
CH
3
CH>-N-CHCH
3 ,CH3CH2-N-CH CHIOH or phenyl substituted by one or several substituents Ra, Ra is selected from -F, -Cl, -Br, -I, -CH 3 ,
-CH
2
CH
3 , -OH, -OCH 3 , -OCH 2
CH
3 , -CH 2
CH
2 OH, -NO 2 , -NH 2 , -N(CH 3 )2, -N(CH 2
CH
3 )2,
-N(CH
2
CH
2 OH )2, -CN, -COOH, -COOCH 3 , -COOCH 2
CH
3 , or -COOC 6
H
5 ;
R
1 ', R 2 ' and R 3 ' are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3
,
4
R
1 CH3 (CH 2 )n or R , wherein n is an integer between 0 and 5; R 1 " and R 2 " are respectively and independently selected from -H, -CH 3 , or -CH 2
CH
3 ;
R
9 , Rio, Rjj, R 1 2 and R 1 3 are respectively and independently selected from -H, -CH 3 ,
-CH
2
CH
3 , -COOH , -COOCH 3 , -COOCH 2
CH
3 , -OH, -OCH 3 , -OCH 2
CH
3 , -CN, -F, -Cl, -Br, -I, or -NH 2 , -N(CH 3
)
2 , or -N(CH 2
CH
3
)
2 ;
R
17 , Ri 8 , R 19 , R 20 , R'17, R'18, R'19, R' 20 , R"17, R"18, R"19 and R" 20 are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3 , -OH, -OCH 3 , -OCH 2
CH
3 , -CF 3 , -CCl 3 , -CBr 3 , -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 , -N(CH 2
CH
3
)
2 , -NHCH 2
CH
2 OH,
-N(CH
2
CH
2
OH)
2 , -NO or -NO 2 , which cannot represent H simultaneously;
R
23 , R 24 , R 25 , R' 23 , R' 24 and R' 25 are respectively and independently selected from -H,
-CH
3 , -CH 2
CH
3 , -F, -Cl, -Br, -I, -OH, -OCH 3 , -OCH 2
CH
3 , -NO 2 , -NH 2 , -NHCH 3 , -N(CH 3
)
2 ,
-NHCH
2
CH
3 , -N(CH 2
CH
3
)
2 , -NHCH 2
CH
2 OH, -N(CH 2
CH
2
OH)
2 , -COOH, -COOCH 3 , or
-COOCH
2
CH
3 ;
R
29 , R 3 o and R 31 are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3 ,
-OCH
3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 , -N(CH 2
CH
3
)
2 ,
-NHCH
2
CH
2 OH, or -N(CH 2
CH
2
OH)
2 ;
R
34 , R 36 and R4 1 are respectively and independently selected from -H, -(CH 2 )n 1
CH
3 ,
-CH
2 OH, -CH 2
CH
2 OH, -CH(CH 3
)
2 or -CH 2
CH(OH)CH
3 , n is an integer between 0 and 5;
R
35 , R 37 , R 38 , R 39 , R 4 o, R 42 and R 43 are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 ,
-N(CH
2
CH
3
)
2 , -NHCH 2
CH
2 OH, or -N(CH 2
CH
2
OH)
2 ; Z is selected from N, 0 or S. R44, R 45 , R 46 , R'44, R' 45 and R' 46 are respectively and independently selected from -H,
-CH
3 , -CH 2
CH
3 , -OH, -OCH 3 , -OCH 2
CH
3 , -NO 2 , -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 ,
-N(CH
2
CH
3
)
2 , -NHCH 2
CH
2 OH, -N(CH 2
CH
2
OH)
2 , -CN or -COOH, -COOCH 3 , or
-COOCH
2
CH
3 ; Rsi, Rs 2 , R si and R s2 are respectively and independently selected from -H, -CH 3 ,
-CH
2
CH
3 , -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 , -N(CH 2
CH
3
)
2 , -NHCH 2
CH
2 OH,
-N(CH
2
CH
2
OH)
2 , -F, -Cl, -Br, -I, or NHCOCH 3 , NHCOCH 2
CH
3 , or NHCOC 6
H
5 ; Rmi, Rm2, Rm3, R mi, R m2 and R m3 are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3 , -F, -Cl, -Br, -I, -OH, -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3
,
5
-N
-N(CH
2
CH
3
)
2 , -NHCH 2
CH
2 OH, -N(CH 2
CH
2
OH)
2 , , NH Rm"-N N or -NHC 6
H
5 ; Rkl, Rk2, RU3, Rk4, Rk5 and Rk6 are respectively and independently selected from -H,
-CH
3 , -CH 2
CH
3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 ,
-N(CH
2
CH
3
)
2 , -NHCH 2
CH
2 OH, or -N(CH 2
CH
2
OH)
2 ; Rei, Rp 2 , RP 3 and Rp 4 are respectively and independently selected from -H, -CH 3 ,
-CH
2
CH
3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 ,
-N(CH
2
CH
3
)
2 , -NHCH 2
CH
2 OH, or -N(CH 2
CH
2
OH)
2 ; Ryi, Ry 2 , Ry 3 and Ry 4 are respectively and independently selected from -H, -CH 3 ,
-CH
2
CH
3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 ,
-N(CH
2
CH
3
)
2 , -NHCH 2
CH
2 OH, or -N(CH 2
CH
2
OH)
2 ; Rmzl is selected from -H, -CH 3 , -CH 2
CH
3 , -CH 2
CH
2 OH, -C 6
H
5 , or -CH 2
C
6
H
5 ; Rmz2 and Rmz3 are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3 , -OCH 3 ,
-CH
2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 , -N(CH 2
CH
3
)
2 , -NHCH 2
CH
2 OH, or -N(CH 2
CH
2
OH)
2 ; Rbzl is selected from -H, -CH 3 , -CH 2
CH
3 , -CH 2
CH
2 OH, -C 6
H
5 , or -CH 2
C
6
H
5 ; Rbz2 and Rbz3 are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3 , -OCH 3 ,
-CH
2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 , -N(CH 2
CH
3
)
2 , -NHCH 2
CH
2 OH, or -N(CH 2
CH
2
OH)
2 ; Y is selected from one group of the following groups: R50 R 5 3 R55 R 59 l 6 0
R
62
R
6 5
R
67 R69 Rn
-CH
3 , R 52
RA
4
R
5
-
6 Rig I~ R 6 3 R 6 6
R
68 Rn F72
R
85 R-N R' 86 7 6 R1189 8, / I89 NR96 RR'90 S R96 R96 R' N N 2 2 R'm2 95 Rm3 R'm3 M3 Rb 4 Rb 3 Rb RbN N N -N| rO Rmz N Rmz N Rpli N NRp 3 Rb 2 Rbi Rbi Rmz 1 Rpl 2 or Rpl 1 N N N KRp1 3 Rpl 2 wherein, R 50 , R 51 , R 5 2 , R 5 3 , R 5 4 , R 55 , R 56 , R 57 , R 58 , R 5 9 , R 60 , R 61 , R 62 , R 63 , R64, R 65 , R 66 ,
R
67 , R 6 8 , R 6 9 , R 70 , R 71 , R 72 and R 73 are respectively and independently selected from -H,
-CH
3 , -CH 2
CH
3 , -CH 2 OH, -OH, -OCH 3 , -OCH 2
CH
3 , -CN, -NO 2 , -NH 2 , -NHCH 3 , -N(CH 3
)
2 ,
-NHCH
2
CH
3 , -N(CH 2
CH
3
)
2 , -NHCH 2
CH
2 OH, -N(CH 2
CH
2
OH)
2 , -F, -Cl, -Br, -I, or -C6H1,
-C
6
H
4
-CH
3 , -C 6
H
4 -OH, -C 6
H
4
-NO
2 , or -C 6
H
4
-NH
2 ;
R
77 , R 78 , R 79 , Rso and R 81 are respectively and independently selected from -H, -CH 3 ,
-CH
2
CH
3 , -OH, -OCH 3 , -OCH 2
CH
3 , -NO 2 , -CN, -COOH, -COOCH 3 , -COOCH 2
CH
3 , -F, -Cl, -Br, -I, -CF 3 , -CCl 3 , -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 , -N(CH 2
CH
3
)
2 ,
-NHCH
2
CH
2 OH, or -N(CH 2
CH
2
OH)
2 ;
R
85 , R 86 and R 8 7 are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3 , -OH or -NH 2 ; R' 85 , R' 86 and R' 8 7 are respectively and independently selected from -H,
-CH
3 , -CH 2
CH
3 , -C 6
H
5 , or -CH 2
C
6
H
4 ; Q is selected from N, 0 or S; Rss, Rs 9 , R 90 , R' ss R' 89 and R' 90 are respectively and independently selected from -H, -CH 2
CH
3 , -OH, -OCH 3
,-OCH
2
CH
3 , -NO 2 , -NH 2
,-NHCH
3 , -N(CH 3
)
2 , -NHCH 2
CH
3
,
7
-N(CH
2
CH
3
)
2 , -NHCH 2
CH
2 OH, -N(CH 2
CH
2
OH)
2 , -CN, -COOH, -COOCH 3 , or
-COOCH
2
CH
3 ;
R
94 , R 95 , R' 94 and R' 95 are respectively and independently selected from -H, -CH 3 ,
-CH
2
CH
3 , -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 , -N(CH 2
CH
3
)
2 , -NHCH 2
CH
2 OH,
-N(CH
2
CH
2
OH)
2 , -F, -Cl, -Br, -I, or -NHCOCH 3 , NHCOCH 2
CH
3 , or NHCOC 6
H
5 ;
R
96 is selected from -H, -CH 3 , -CH 2
CH
3 , -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 ,
-N(CH
2
CH
3
)
2 , -NHCH 2
CH
2 OH, or -N(CH 2
CH
2
OH)
2 ; R' 96 is selected from -H, -CH 3 ,
-CH
2
CH
3 , -C 6
H
5 , or -CH 2
C
6
H
4 ; Rmi, Rm2, Rm3, R mi, R m2 and R m3 are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3 , -F, -Cl, -Br, -I, -OH, -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 ,
-N(CH
2
CH
3
)
2 , -NHCH 2
CH
2 OH, -N(CH 2
CH
2
OH)
2 , or -NHC 6 Hs; Rbl, Rb2, R3 and R4 are respectively and independently selected from -H, -CH 3 ,
-CH
2
CH
3 , -CH 2 OH, -OH, -OCH 3 , -OCH 2
CH
3 , -CN, -NO 2 , -NH 2 , -NHCH 3 , -N(CH 3
)
2 ,
-NHCH
2
CH
3 , -N(CH 2
CH
3
)
2 , -NHCH 2
CH
2 OH, -N(CH 2
CH
2
OH)
2 , -F, -Cl, -Br, or -I; Rmzi is selected from -H, -CH 3 , -CH 2
CH
3 , -CH 2
CH
2 OH, -C 6
H
5 , or -CH 2
C
6
H
5 ; Rmz 2 and Rmz 3 are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3 , -OCH 3 ,
-CH
2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3
)
2 , -NHCH 2
CH
3 , -N(CH 2
CH
3
)
2 , -NHCH 2
CH
2 OH,
-N(CH
2
CH
2
OH)
2 , -CONH 2 , or -COOH; Rpr and Rp 1 2 are respectively and independently selected from -H, -CH 3 , -CH 2
CH
3 , OH, -OCH 3 , -OCH 2
CH
3 , F, Cl, Br, or I; Rp 1 3 is selected from -H, -CH 3 , -CH 2
CH
3 ,
-CH
2
CH
2 OH, -C 6
H
5 , or -CH 2
C
6
H
5 . Preferably, X represents monosubstituted or polysubstitued or unsubstituted alkoxy, monosubstituted or polysubstitued or unsubstituted alkyl, monosubstituted or polysubstituted or unsubstituted alkenyl, monosubstituted or bisubstituted or unsubstituted thienyl, monosubstituted or bisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstituted pyridazinyl, monosubstituted or bisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or unsubstituted pyrazinyl, monosubstituted or bisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted phenyl, monosubstituted or bisubstituted or unsubstituted pyrimidinyl, monosubstituted or bisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or unsubstituted quinolinyl, monosubstituted or bisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or unsubstituted indolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrazolyl.
8 More preferably, X represents C1-C6 alkyloxy substituted by nitro, amino, hydroxyl or aryl; , C1-C6 alkyl substituted by nitro, amino, hydroxyl or aryl; C2-C14 alkenyl substituted by alkyl, hydroxyl or aryl; thienyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted thienyl; pyidyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted pyridyl; quinolinyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted quinolinyl; indolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted indolyl; pyridyl monosubstituted or bisubstituted by C1-C6 alkoxy; pyridyl monosubstituted or bisubstituted by C1-C3 dialkylamino; pyridyl monosubstituted or bisubstituted by C1-C6 alkyl; unsubstituted pyridyl; pyridazinyl monosubstituted by C1-C6 alkoxy; pyridazinyl monosubstituted by C1-C6 alkyl; unsubstituted pyridazinyl; unsubstituted piperazinyl; piperazinyl bisubstituted by C1-C6 alkyl; unsubstituted piperidinyl; unsubstituted pyrazinyl; unsubstituted thiazolyl; imidazolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted imidazolyl; thiazolyl bisubstituted by C1-C6 alkyl and nitro; unsubstituted pyrimidinyl; pyrimidinyl monosubstituted by phenyl; pyrimidinyl bisubstituted by amino and a group selected from nitro, -F, -Cl, -Br or -I; phenyl trisubstituted by trihydroxyl; phenyl trisubstituted by trimethoxyl; phenyl bisubstituted by hydroxyl and methoxyl; imidazolyl substituted by a group selected from methyl, ethyl, carboxyl or amido; pyrazolyl bisubstituted or trisubstituted by a group selected from C1-C6 alkyl or aryl and a group selected from -F, -Cl, -Br or -I. Preferably, Y represents hydroxyl, C 1
-C
6 alkyl, monosubstituted or bisubstituted or trisubstituted phenyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstitued pyrazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzpyrimidinyl, monosubstituted or bisubstituted or trisubstituted or tetrasubstituted or unsubstituted benzimidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzimidazolonyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted purinyl. More preferably, Y represents hydroxymethyl, hydroxyethyl, aminophenyl, hydroxyphenyl, C1-C 6 alkylphenyl, phenyl monosubstituted by -F, -Cl, -Br or -I, phenyl bisubstituted by hydroxyl and carboxyl, hydroxyethyl bisubstituted by hydroxylmethyl or C1-C 6 alkyl and monosubstituted phenyl, piperazinyl monosubstituted or bisubstituted or 9 trisubstituted or unsubstituted by C 1
-C
6 alkyl, pyridyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C 1
-C
6 alkyl, pyrazinyl monosubstituted or bisubstituted or unsubstituted, by C 1
-C
6 alkyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C 1
-C
6 alkyl, pyrrolyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C 1
-C
6 alkyl, thiazolyl monosubstituted by C 1
-C
6 alkyl, pyrimidinyl monosubstituted or bisubstituted or unsubstituted by C 1
-C
6 alkyl, pyrimidinyl monsubstituted by C 1
-C
6 alkyl and bisubstituted by hydroxyl, pyrimidinyl monosubstituted
C
1
-C
6 alkyl and bisubstituted or trisubstituted by -F, -Cl, -Br or -I, purinyl monosubstituted or bisubstituted or unsubstituted by C 1
-C
6 alkyl, purinyl monosubstituted by C 1
-C
6 alky and substituted or trisuvstituted by hydroxyl. Most preferably , the benzimidazole-4-carboxamide derivatives as shown in Formula (1) includes the following compounds: (1)(L)-2-(5-nitro-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide (2)(L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide (3)(L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (4)2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxy ethyl)] amide (5)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (6)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-chlorophenyl)amide (7)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-bromophenyl)amide (8)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (9)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-chlorophenyl)amide (10)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-bromophenyl)amide (11)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (12)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-chlorophenyl)amide (13)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-bromophenyl)amide (14)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-methylphenyl)amide (15)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-hydroxylphenyl)amide (16)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 10 (17)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-m-methylphenyl)amide (1 8)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-m-hydroxylphenyl)amide (1 9)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (20)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-p-methylphenyl)amide (21)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-p-hydroxylphenyl)amide (22)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (23)(L)-2-(4-methoxypyridyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-nitrophenylh ydroxyethyl)]amide (24)(L)-2-(4-methoxypyridyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (25)2-(4-methoxypyridyl)- 1H-benzimidazole-4-[N-(1 -methyl-2-p-chlorophenylhydroxyeth yl)]amide (26)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (27)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o-chlorophenyl)amide (28)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o-bromophenyl)amide (29)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (30)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (31)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (32)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (33)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (34)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (35)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (36)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (37)(L)-2-(6-methoxypyridyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-nitrophenylh ydroxyethyl)]amide (3 8)(L)-2-(6-methoxypyridyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (39)2-(6-methoxypyridyl)- 1H-benzimidazole-4-[N-(1 -methyl-2-p-chlorophenylhydroxyeth yl)]amide (40)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (41)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide 11 (42)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (43)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (44)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (45)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (46)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (47)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (48)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (49)(L)-2-(4-dimethylaminopyridyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (50)(L)-2-(4-dimethylaminopyridyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (51)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophenylhydro xyethyl)]amide (52)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (53)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (54)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (55)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (56)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (57)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (58)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (59)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (60)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (61)(L)-2-(3-pyridazinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide (62)(L)-2-(3-pyridazinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (63)2-(3-pyridazinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]a mide (64)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl) amide (65)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl) amide (66)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl) amide 12 (67)2-(3 -pyridazinyl)-l1H-benzimidazole-4-(N-o-hydroxyphenyl) amide (68)2-(3 -pyridazinyl)-l1H-benzimidazole-4-(N-o-aminophenyl) amide (69)2-(3 -pyridazinyl)-l1H-benzimidazole-4-(N-m-hydroxyphenyl) amide (70)2-(3 -pyridazinyl)-l1H-benzimidazole-4-(N-m-aminophenyl) amide (71 )2-(3 -pyridazinyl)- 1 H-benzimidazole-4-(N-p-hydroxyphenyl)amide (72)2-(3 -pyridazinyl)-l1H-benzimidazole-4-(N-p-aminophenyl) amide (73 )(L)-2-(2-N-methyl-4-N-methylpiperazinyl)-l1H-benzimidazole-4- [N-(l1-hydroxymethyl 2-p-nitrophenylhydroxyethyl)] amide (74)(L)-2-(2-N-methyl-4-N-methylpiperazinyl)-l1H-benzimidazole-4- [N-(l1-hydroxymethyl 2-p-aminophenylhydroxyethyl)] amide (75 )2-(2-N-methyl-4-N-methylpiperazinyl)-l1H-benzimidazole-4- [N-(l1-methyl-2-p-chlorop henylhydroxyethyl)] amide (76)2-(2-N-methyl-4-N-methylpiperazinyl)-l1H-benzimidazole-4-(N-o-fluorophenyl)amide (77)2-(2-N-methyl-4-N-methylpiperazinyl)-l1H-benzimidazole-4-(N-m-fluorophenyl)amide (78)2-(2-N-methyl-4-N-methylpiperazinyl)-l1H-benzimidazole-4-(N-p-fluorophenyl)amide (79)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (80)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (81 )2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (82)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-m-aminophenyl)amide (83 )2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (84)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-p-aminophenyl)amide (85 )(L)-2-(2-pyrazinyl)- 1 H-benzimidazole-4- [N-( 1 -hydroxymethyl-2-p-nitrophenylhydrox yethyl)] amide (86)(L)-2-(2-pyrazinyl)- 1 H-benzimidazole-4- [N-( 1 -hydroxymethyl-2-p-aminophenylhydro xyethyl)] amide (87)2-(2-pyrazinyl)- 1H-benzimidazole-4- [N-(l1-methyl-2-p-chlorophenylhydroxyethyl)] amide (8 8)2-(2-pyrazinyl)- 1 H-benzimidazole-4-(N-o-fluorophenyl)amide (89)2-(2-pyrazinyl)- 1 H-benzimidazole-4-(N-m-fluorophenyl)amide (90)2-(2-pyrazinyl)- 1 H-benzimidazole-4-(N-p-fluorophenyl)amide (91 )2-(2-pyrazinyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (92)2-(2-pyrazinyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide 13 (93)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (94)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (95)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (96)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (97)(L)-2-N-piperazinyl- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydrox yethyl)]amide (98)(L)-2-N-piperazinyl- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (99)2-N-piperazinyl- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (100)2-N-piperazinyl- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (101)2-N-piperazinyl- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (102)2-N-piperazinyl- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (103)2-N-piperazinyl- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (104)2-N-piperazinyl- 1H-benzimidazole-4-(N-o-aminophenyl)amide (105)2-N-piperazinyl- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (106)2-N-piperazinyl- 1H-benzimidazole-4-(N-m-aminophenyl)amide (107)2-N-piperazinyl- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (108)2-N-piperazinyl- 1H-benzimidazole-4-(N-p-aminophenyl)amide (109)(L)-2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4- [N- (1 -hydroxymethyl-2-p-nit rophenylhydroxyethyl)]amide (110)(L)-2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-am inophenylhydroxyethyl)]amide (111)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylh ydroxyethyl)]amide (112)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (113)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (114)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (115)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (116)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (117)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (118)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide 14 (119)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (120)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (121)(L)-2-thiazolyl- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (122)(L)-2-thiazolyl- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-aminophenylhydroxye thyl)]amide (123)2-thiazolyl- 1H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophenylhydroxyethyl)] amide (124)2-thiazolyl- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (125)2-thiazolyl- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (126)2-thiazolyl- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (127)2-thiazolyl- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (128)2-thiazolyl- 1H-benzimidazole-4-(N-o-aminophenyl)amide (129)2-thiazolyl- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (130)2-thiazolyl- 1H-benzimidazole-4-(N-m-aminophenyl)amide (131)2-thiazolyl- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (132)2-thiazolyl- 1H-benzimidazole-4-(N-p-aminophenyl)amide (133)(L)-5-thiazolyl- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (134)(L)-5-thiazolyl- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxye thyl)]amide (135)5-thiazolyl- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (136)5-thiazolyl- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (137)5-thiazolyl- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (138)5-thiazolyl- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (139)5-thiazolyl- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (140)5-thiazolyl- 1H-benzimidazole-4-(N-o-aminophenyl)amide (141)5-thiazolyl- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (142)5-thiazolyl- 1H-benzimidazole-4-(N-m-aminophenyl)amide (143)5-thiazolyl- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (144)5-thiazolyl- 1H-benzimidazole-4-(N-p-aminophenyl)amide (145)(L)-2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop 15 henylhydroxyethyl)]amide (146)(L)-2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (147)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophenylhydro xyethyl)]amide (148)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (149)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (1 50)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (151)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1 52)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (153)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (1 54)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (155)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (156)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (1 57)(L)-2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (158)(L)-2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (159)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophenylhydro xyethyl)]amide (1 60)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (161)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (1 62)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (163)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1 64)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (165)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (1 66)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (1 67)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (1 68)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (1 69)(L)-2-(2-pyrimidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide 16 (170)(L)-2-(2-pyrimidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhy droxyethyl)]amide (171)2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (172)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (173)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (174)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (175)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (176)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (177) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (178)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (179)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (1 80)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (181)(L)-2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (1 82)(L)-2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (183)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydr oxyethyl)]amide (184)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (185)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (186)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (187)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (188)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (189)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (190)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (191)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (192)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (193)(L)-2-(4-amino-6-chloro-5 -pyrimidinyl)- 1 H-benzimidazole-4- [N- (1 -hydroxymethyl-2 -p-nitrophenylhydroxyethyl)] amide (194)(L)-2-(4-amino-6-chloro-5 -pyrimidinyl)- 1 H-benzimidazole-4- [N-(1 -hydroxymethyl-2 -p-aminophenylhydroxyethyl)]amide 17 (195)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-[N-(1 -methyl-2-p-chlorophe nylhydroxyethyl)]amide (1 96)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-o-fluorophenyl)amide (1 97)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-m-fluorophenyl)amide (1 98)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-p-fluorophenyl)amide (1 99)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (200)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (201)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (202)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-m-aminophenyl)amide (203)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-p-hydroxyphenyl)amide (204)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-p-aminophenyl)amide (205)(L)-2-(2-pyrrolyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (206)(L)-2-(2-pyrrolyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (207)2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (208)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (209)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (210)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (211)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (212)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (213)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (214)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (215)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (216)(L)-2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophe nylhydroxyethyl)]amide (217)(L)-2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminoph enylhydroxyethyl)]amide (218)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxy ethyl)]amide (219)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide 18 (220)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (221)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (222)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (223)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (224)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (225)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (226)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (227)(L)-2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (228)(L)-2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (229)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-[N-(1 -methyl-2-p-chlorophenylhydr oxyethyl)]amide (230)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (231)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (232)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (233)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (234)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (235)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (236)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (237)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (238)(L)-2-(2-quinolinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide (239)(L)-2-(2-quinolinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (240)2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (241)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (242)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (243)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (244)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (245)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide 19 (246)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (247)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (248)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (249)(L)-2-(3-quinolinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide (250)(L)-2-(3-quinolinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (251)2-(3-quinolinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]a mide (252)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (253)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (254)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (255)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (256)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (257)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (258)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (259)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (260)(L)-2-(2-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (261)(L)-2-(2-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide (262)2-(2-piperidinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (263)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (264)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (265)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (266)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (267)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (268)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (269)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (270)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (271)(L)-2-(3-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydr 20 oxyethyl)] amide (272)(L)-2-(3 -piperidinyl)- 1 H-benzimidazole-4- [N-( 1 -hydroxymethyl-2-p-aminophenylhyd roxyethyl)] amide (273)2-(3-piperidinyl)- 1H-benzimidazole-4-[N-( 1 -methyl-2-p-chlorophenylhydroxyethyl)]amide (274)2-(3 -piperidinyl)- 1 H-benzimidazole-4-(N-o-fluorophenyl)amide (275 )2-(3 -piperidinyl)- 1 H-benzimidazole-4-(N-m-fluorophenyl)amide (276)2-(3 -piperidinyl)- 1 H-benzimidazole-4-(N-p-fluorophenyl)amide (277)2-(3 -piperidinyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (278)2-(3 -piperidinyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (279)2-(3 -piperidinyl)- 1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (280)2-(3 -piperidinyl)- 1 H-benzimidazole-4-(N-m-aminophenyl)amide (281 )2-(3 -piperidinyl)- 1 H-benzimidazole-4-(N-p-hydroxyphenyl)amide (282)(L)-2-(4-piperidinyl)- 1 H-benzimidazole-4- [N-( 1 -hydroxymethyl-2-p-nitrophenylhydr oxyethyl)] amide (283 )(L)-2-(4-piperidinyl)- 1 H-benzimidazole-4- [N-( 1 -hydroxymethyl-2-p-aminophenylhyd roxyethyl)] amide (284)2-(4-piperidinyl)- 1H-benziimidazole-4-[N-(l1-methyl-2-p-chlorophenylhydroxyethyl)]amide (285 )2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-o-fluorophenyl)amide (286)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-m-fluorophenyl)amide (287)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-p-fluorophenyl)amide (28 8)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (289)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (290)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (291 )2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-m-aminophenyl)amide (292)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (293 )(L)-2-(3 -indolyl)- 1 H-benzimidazole-4- [N-(l1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)] amide (294)(L)-2-(3 -indolyl)- 1 H-benzimidazole-4- [N-(l1-hydroxymethyl-2-p-aminophenylhydrox yethyl)] amide (295)2-(3-indolyl)- 1H-benzimidazole-4- [N-(l1-methyl-2-p-chlorophenylhydroxyethyl)] amide (296)2-(3 -indolyl)- 1 H-benzimidazole-4-(N-o-fluorophenyl)amide 21 (297)2-(3-indolyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (298)2-(3-indolyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (299)2-(3-indolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (300)2-(3-indolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (301)2-(3-indolyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (302)2-(3-indolyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (303)2-(3-indolyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (304)(L)-2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (305)(L)-2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (306)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydr oxyethyl)]amide (307)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (308)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (309)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (310)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (311)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (312)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (313)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (314)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (315)(L)-2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p nitrophenylhydroxyethyl)] amide (316)(L)-2-(3 -hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p aminophenylhydroxyethyl)]amide (317)2-(3 -hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4- [N-(1 -methyl-2-p-chloropheny lhydroxyethyl)]amide (318)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (319)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (320)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (321)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide 22 (322)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (323)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (324)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (325)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (326)(L)-2-methoxy- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (327)(L)-2-methoxy- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxye thyl)]amide (328)2-methoxy- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (329)2-methoxy- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (330)2-methoxy- 1H-benzimidazole-4-(N-2-piperazinyl)amide (331)2-methoxy- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (332)2-methoxy- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (333)2-methoxy- 1H-benzimidazole-4-(N-o-aminophenyl)amide (334)2-methoxy- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (335)2-methoxy- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (336)2-methoxy- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (337)2-methoxy- 1H-benzimidazole-4-(N-2-imidazolyl)amide (338)2-methoxy- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (339)2-methoxy- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (340)2-methoxy- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (341)2-methoxy- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (342)2-methoxy- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (343)2-methoxy- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (344)2-methoxy- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (345)2-methoxy- 1H-benzimidazole-4-(N-2-pyridyl)amide (346)2-methoxy- 1H-benzimidazole-4-(N-3-pyridyl)amide (347)2-methoxy- 1H-benzimidazole-4-(N-4-pyridyl)amide (348)2-methoxy- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (349)2-methoxy- 1H-benzimidazole-4-(N-5-thiazolyl)amide (350)2-methoxy- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 23 (351)2-methoxy- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (352)2-methoxy- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (353)2-methoxy- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (354)(L)-2-ethoxy- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl )]amide (355)(L)-2-ethoxy- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyeth yl)]amide (356)2-ethoxy- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (357)2-ethoxy- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (358)2-ethoxy- 1H-benzimidazole-4-(N-2-piperazinyl)amide (359)2-ethoxy- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (360)2-ethoxy- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (361)2-ethoxy- 1H-benzimidazole-4-(N-o-aminophenyl)amide (362)2-ethoxy- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (363)2-ethoxy- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (364)2-ethoxy- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (365)2-ethoxy- 1H-benzimidazole-4-(N-2-imidazolyl)amide (366)2-ethoxy- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (367)2-ethoxy- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (368)2-ethoxy- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (369)2-ethoxy- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (370)2-ethoxy- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (371)2-ethoxy- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (372)2-ethoxy- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (373)2-ethoxy- 1H-benzimidazole-4-(N-2-pyridyl)amide (374)2-ethoxy- 1H-benzimidazole-4-(N-3-pyridyl)amide (375)2-ethoxy- 1H-benzimidazole-4-(N-4-pyridyl)amide (376)2-ethoxy- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (377)2-ethoxy- 1H-benzimidazole-4-(N-5-thiazolyl)amide (378)2-ethoxy- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (379)2-ethoxy- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 24 (3 80)2-ethoxy- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (3 81)2-ethoxy- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (3 82)(L)-2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4- [N-( 1 -hydroxymethyl-2-p-ni trophenylhydroxyethyl)] amide (3 83)(L)-2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4- [N-( 1 -hydroxymethyl-2-p-a minophenylhydroxyethyl)] amide (3 84)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4- [N-( 1 -methyl-2-p-chlorophenyl hydroxyethyl)] amide (3 85)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (3 86)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2-piperazinyl)amide (3 87)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (3 8 8)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (3 89)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (3 90)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (391 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazol yl)amide (392)2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (393 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (3 94)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (395 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (3 96)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (3 97)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (3 98)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (3 99)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (400)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (401 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (402)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (403 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (404)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (405 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (406)2-(2,6-dimnethyl-2,6-octadienyl)- 1H-benziniidazole-4-(N-2,4-dihydroxyl-5-pyriniidinyl)amiide 25 (407)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (408)2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidi nyl)amide (409)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (410)(L)-2-pyrazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (411)(L)-2-pyrazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (412) 2-pyrazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (413) 2-pyrazolyl-1H-benzimidazole-4-(N-N'-piperidinyl)amide (414) 2-pyrazolyl-1H-benzimidazole-4-(N-2-piperazinyl)amide (415) 2-pyrazolyl-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (416) 2-pyrazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (417) 2-pyrazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide (418) 2-pyrazolyl-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (419) 2-pyrazolyl-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (420) 2-pyrazolyl-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (421) 2-pyrazolyl-1H-benzimidazole-4-(N-2-imidazolyl)amide (422) 2-pyrazolyl-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (423) 2-pyrzazolyl-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (424) 2-pyrazolyl-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (425) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrazinyl)amide (426) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (427) 2-pyrazolyl-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (428) 2-pyrazolyl-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (429) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyridyl)amide (430) 2-pyrazolyl-1H-benzimidazole-4-(N-3-pyridyl)amide (431) 2-pyrazolyl-1H-benzimidazole-4-(N-4-pyridyl)amide (432) 2-pyrazolyl-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (433) 2-pyrazolyl-1H-benzimidazole-4-(N-5-thiazolyl)amide (434) 2-pyrazolyl-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (435) 2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (436) 2-pyrazolyl-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 26 (437) 2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (43 8)(L)-2-(2'-pyridyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (439)(L)-2-(2'-pyridyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (440)2-(2'-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (441) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (442) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (443) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (444) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (445) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (446) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (447) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (448) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (449) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (450) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (451) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (452) 2-(2'-pyridyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (453) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (454) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (455) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (456) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (457) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (458) 2-(2'-pyridyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (459) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (460) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (461)2-(2'-pyridyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (462)2-(2'-pyridyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (463)2-(2'-pyridyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (464)2-(2'-pyridyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (465)2-(2'-pyridyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 27 (466)(L)-2-(3 '-pyridyl)- 1H-benzimidazole-4-[N-(1-hydmoxymethyl-2-p-nitrophenylhydroxyethyl)]amide (467)(L)-2-(3 '-pyridyl)- 1 H-benzimidazole-4- [N-( 1 -hydroxymethyl-2-p-aminophenylhydro xyethyl)] amide (468)2-(3 '-pyridyl)-l1H-benzimidazole-4-[N-(l1-methyl-2-p-chlorophenylhydroxyethyl)] amide (469)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (470)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-2-piperazinyl)amide (471 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (472)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (473 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (474)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (475 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (476)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (477)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (478)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (479)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (480)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (481 )2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (482)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (483 )2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (484)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (485 )2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (486)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (487)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (48 8)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (489)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (490)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (491 )2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (492)2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (493 )2-(3 '-pylidyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (494)(L)-2-(4'-pyridyl)- 1H-benzimidazole-4-[N-(1-hydmoxymethyl-2-p-nitrophenylhydroxyethyl)]amide (495 )(L)-2-(4 '-pyridyl)- 1 H-benzimidazole-4- [N-(l1-hydroxymethyl-2-p-aminophenylhydro 28 xyethyl)]amide (496)2-(4'-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (497)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (498)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide (499)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (500)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (501)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (502)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (503)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (504)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (505)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (506)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (507)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (508)2-(4'-pyridyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (509)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (510)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (511)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (512)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (513)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (514)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (515)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (516)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (517)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (518)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (519)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (520)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (521)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (522)(L)-2-(2'-imidazolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (523)(L)-2-(2'-imidazolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhy droxyethyl)]amide 29 (524)2-(2'-imidazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (525)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (526)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide (527)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (528)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (529)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (530)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (531)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (532)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (533)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (534)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (535)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (536)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (537)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (53 8)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (539)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (540)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (541)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (542)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (543)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (544)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (545)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (546)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (547)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (548)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (549)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (550)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (551)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide (552)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (553)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 30 (554)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (555)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (556)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (557)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (558)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (559)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (560)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (561)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (562)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (563)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (564)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (565)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (566)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (567)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (568)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (569)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (570)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (571)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (572)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (573)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (574)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide (575)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (576)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (577)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (578)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (579)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (580)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (581)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (582)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (583)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide 31 (584)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (585)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (586)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (587)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (588)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (589)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (590)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (591)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (592)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (593)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (594)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (595)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (596)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (597)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (598)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2' -benzimidazolyl)amide (599)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (600)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (601)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (602)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (603)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4' -pyrazolyl)amide (604)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-(N' -piperazinyl))amide (605)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (606)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (607)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (608)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (609)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (610)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (611)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (612)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (613)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 32 (61 4)2-(4-dimethylamiinopyridyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (6 15)2-(4-dimethylaminopyridyl)- 1H-benziniidazole-4-(N-2,4-dihydroxyl-5-pyriniidinyl)amide (61 6)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (6 17)2-(4-dimnethylaminopyridyl)- 1H-benziniidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (61 8)2-(4-dimethylaminopyridyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (61 9)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (620)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (621 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (622)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (623 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (624)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (625 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (626)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (627)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (628)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (629)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (630)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (631 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (632)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (633 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (634)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (635 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (63 6)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (637)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (63 8)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (63 9)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (640)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (641 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (642)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (643 )2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-2-piperazinyl))amide 33 (644)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-2' -benzimidazolyl)amide (645)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (646)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imid azolyl)amide (647)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazol yl)amide (648)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-2-imidazolyl)amide (649)2-(2-N-methyl-4- N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (650)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-(N' -piperazinyl))amide (65 1)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (652)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-2-pyrazinyl)amide (653 )2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-2-pyrimidinyl)amide (654)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-4-pyrimidinyl)amide (655 )2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-5 -pyrimidinyl)amide (65 6)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-2-pyridyl)amide (657)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-3 -pyridyl)amide (65 8)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-4-pyridyl)amide (65 9)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benziimidazole-4-(N-4-methyl-5-thiazolyl)amide (660)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-5 -thiazolyl)amide (661 )2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimi dinyl)amide (662)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimi dinyl)amide (663 )2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyri midinyl)amide (664)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidi nyl)amide (665 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-N' -piperidinyl)amide (666)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2-piperazinyl))amide (667)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2' -benzimidazolyl)amide (668)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-5 -benzimidazolonyl)amide 34 (669)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (67O)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (671 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2-imidazolyl)amide (672)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4' -pyrazolyl)amide (673 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-(N' -piperazinyl))amide (674)2-(2-pyrazinyl)-l H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (675 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2-pyrazinyl)amide (676)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2-pyrimidinyl)amide (677)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4-pyrimidinyl)amide (678)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-5 -pyrimidinyl)amide (679)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2-pyridyl)amide (68O)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-3 -pyridyl)amide (681 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4-pyridyl)amide (682)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (683 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-5 -thiazolyl)amide (684)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (685 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (686)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (687)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (68 8)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (689)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (690)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (691 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (692)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (693 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (694)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (695 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (696)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (697)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (698)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide 35 (699)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (700)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (701 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (702)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (703 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (704)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (705 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (706)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (707)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (708)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (709)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (71 0)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (711 )2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (71 2)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (713 )2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (71 4)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (7 15)2-(4-methyl-5-aminothiazolyl)- 1H-benziimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (71 6)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (71 7)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (71 8)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (71 9)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (720)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (721 )2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (722)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (723 )2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (724)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (725 )2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (726)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (727)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (728)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide 36 (729)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (730)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (731)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (732)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidi nyl)amide (733)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (734)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-N'-piperidinyl)amide (735)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (73 6)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-2'-benzimidazolyl)amide (737)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-5-benzimidazolonyl)amide (73 8)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (73 9)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (740)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (741)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-4'-pyrazolyl)amide (742)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-(N'-piperazinyl))amide (743)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (744)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (745)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (746)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (747)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (748)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (749)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (750)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (751)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (752)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-5-thiazolyl)amide (753)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (754)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (755)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (756)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (757)2-(5-thiazolyl)- 1 H-benzimidazole-4-(N-N'-piperidinyl)amide (75 8)2-(5-thiazolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide 37 (759)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (760)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (761)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (762)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (763)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (764)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (765)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (766)2-(5-thiazolyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (767)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (768)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (769)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (770)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (771)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (772)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (773)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (774)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (775)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (776)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (777)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (778)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (779)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (780)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (781)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (782)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (783)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (784)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (785)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (786)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (787)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (788)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide 38 (789)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (790)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (791 )2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (792)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (793 )2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (794)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (795 )2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (796)2-(2- pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (797)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (798)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (799)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (800)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (801 )2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (802)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (803 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (804)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (805 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2 ' -benzimidazolyl)amide (806)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (807)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (808)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4 '-carboxyl-5 '-imidazolyl)amide (809)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (81 0)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4 ' -pyrazolyl)amide (811 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (81 2)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (813 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (81 4)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (815 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (81 6)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (81 7)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (81 8)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide 39 (81 9)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (820)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (821 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (822)2-(2-phenyl-5-pyrimidinyl)- 1H-benziniidazole-4-(N-2,4-dihydroxyl-5-pyriniidinyl)amide (823)2-(2-phenyl-5 -pyrimidinyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (824)2-(2-phenyl-5-pyrimidinyl)- 1H-benziniidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amiide (825 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (826)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (827)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (828)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (829)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (830)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidaz olyl)amide (83 1)2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benziniidazole-4-(N-4' -carboxyl-5 '-iniidazolyl)amide (832)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (833 )2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (834)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (835 )2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (83 6)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (837)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (83 8)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (83 9)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (840)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (841 )2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (842)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (843)2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benziniidazole-4-(N-4-methyl-5-thiazolyl)amide (844)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (845 )2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidi nyl)amide (846)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidin yl)amide 40 (847)2-(4-amino-6-cfloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimi dinyl)amide (848)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl )amide (849)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (85O)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (851 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (852)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (853 )2-(2-pyrrolyl)-l1H-benzimidazole-4-(N-4' - carbonamido -5' -imidazolyl)amide (854)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (855 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (85 6)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (857)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (85 8)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (85 9)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (86O)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (861 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (862)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (863 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (864)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (865 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (866)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (867)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (868)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (869)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (87O)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (871 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (872)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (873 )2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (874)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (875 )2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide 41 (876)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (877)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (878)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (879)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (8 80)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (8 81)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (8 82)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (8 83)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (8 84)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (8 85)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (8 86)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (8 87)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (8 8 8)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (8 89)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (890)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (891 )2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (892)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (893)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amiide (894)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (895 )2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (896)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (897)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (898)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (899)2-(3 ,5-dimethyl-2-pyrrolyl)- 1H-benziniidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (900)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (901 )2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (902)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (903 )2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (904)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (905 )2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide 42 (906)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (907)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (908)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (909)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (91 O)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (911 )2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (91 2)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (913 )2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (91 4)2-(3 ,5 -dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (91 5)2-(3 ,5 -dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (91 6)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1H-benziniidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (91 7)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (91 8)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-N' -piperidinyl)amide (91 9)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (920)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (921 )2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (922)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (923 )2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (924)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (925 )2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (926)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (927)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (928)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (929)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (930)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (931 )2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (932)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (933 )2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (934)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (935 )2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide 43 (93 6)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (937)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (93 8)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (93 9)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (940)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (941 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (942)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (943 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (944)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (945 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (946)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (947)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (948)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (949)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (950)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (951 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (952)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (953 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (954)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (955 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (95 6)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (957)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (95 8)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (95 9)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (960)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (961 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (962)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (963 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (964)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (965 )2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide 44 (966)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (967)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (968)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (969)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (970)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (971)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (972)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (973)2-(3-piperidinyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (974)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (975)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (976)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (977)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (978)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (979)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (980)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (981)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (982)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (983)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (984)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (985)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (986)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (987)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (988)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (989)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (990)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (991)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (992)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (993)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (994)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (995)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide 45 (996)2-(4-piperidinyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (997)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (998)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (999)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1000)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-5-pyrimidinyl)amide (1001)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (1002)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (1003)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (1004)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1005)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-5-thiazolyl)amide (1006)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1007)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (1008)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1009)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1010)2-(3-indolyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (1011 )2-(3-indolyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (1012)2-(3-indolyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1013 )2-(3-indolyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1014)2-(3-indolyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (1015 )2-(3-indolyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (101 6)2-(3-indolyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (1017)2-(3-indolyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (101 8)2-(3-indolyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (101 9)2-(3-indolyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1020)2-(3-indolyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (1021)2-(3-indolyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1022)2-(3-indolyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1023)2-(3-indolyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1024)2-(3-indolyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (1025)2-(3-indolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide 46 (1 026)2-(3-indolyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (1 027)2-(3-indolyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (1 028)2-(3-indolyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (1 029)2-(3-indolyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (1 030)2-(3-indolyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (1031 )2-(3-indolyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1 032)2-(3-indolyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (1033 )2-(2,3 ,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (1 034)2-(2,3 ,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (1035 )2-(2,3 ,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (103 6)2-(2,3 ,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (1037)2-(2,3,4-trimethoxyphenyl)- 1H-benziimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (103 8)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (103 9)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (1 040)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (1041 )2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (1 042)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (1043 )2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1 044)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (1045 )2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1 046)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (1 047)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (1 048)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (1 049)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (1 050)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (1051 )2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (1052)2-(2,3 ,4-trimethoxyphenyl)- 1H-benzincdazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1053)2-(2,3 ,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-4,6-dimnethoxy-2-pyrimidinyl)amiide (1054)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1055 )2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide 47 (105 6)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (1 057)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (105 8)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (105 9)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (1 060)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazol yl)amide (1061 )2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (1 062)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (1063 )2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (1 064)2-(3-hydroxyl-4-methoxtphenyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (1065 )2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (1 066)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1 067)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (1 068)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1 069)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (1 070)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (1071 )2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (1 072)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (1073 )2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (1 074)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (1075 )2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidin yl)amide (1 076)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidiny 1)amide (1 077)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimid inyl)amide (1078)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1 079)(L)-2-(2-bromo-5 -pyridine)- 1H-benziniidazole-4-[N-(l1-hydroxymethyl-2-p-nitrophenylhy droxyethyl)] amide (1 080)(L)-2-(2-bromo-5 -pyridine)- 1H-benzimidazole-4-[N-(l1-hydroxymethyl-2-p-aminophenylh ydroxyethyl)]amide 48 (108 1)2-(2-bromo-5-pyridine)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chorophenylhydroxyethyl)]amide (1 082)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (1083 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (1 084)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (1085 )2-(2-bromo-5 -pyridine)- 1H-benziniidazole-4-(N-o-hydroxyphenyl)amide (1 086)2-(2-bromo-5 -pyridine)- 1H-benziniidazole-4-(N-o-aminophenyl)amide (1 087)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (108 8)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (1 089)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (1 090)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (1091 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (1 092)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (1093 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (1 094)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1095 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (1 096)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1 097)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (1 098)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (1 099)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (1 100)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (1 101 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (1 102)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (1 103 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (1 104)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4,6-di(2-bromo-5 -pyridine)-2-pyrimi dinyl)amide (1 105)2-(2-bromo-5-pyridine)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1 106)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (1 107)(L)-2-(2-amino-3 -pyridine)- 1H-benziniidazole-4-[N-( 1-hydroxymethyl-2-p-nitrophenylhy droxyethyl)] amide (1 108)(L)-2-(2-amino-3 -pyridine)- 1H-benziniidazole-4-[N-( 1-hydroxymethyl-2-p-aminophenylh ydroxyethyl)]amide 49 (1109)2-(2-amino-3-pyridine)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (11 10)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-N' -piperidinyl)amide (1111)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (1112)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2' -benzimidazolyl)amide (1113)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1114)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (1115)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1116)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (1117)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (1118)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (1119)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4' -pyrazolyl)amide (1120)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (1121)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (1122)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (1123)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1124)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1125)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1126)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-pyridyl)amide (1127)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-3-pyridyl)amide (1128)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4-pyridyl)amide (1129)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1130)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (1131)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1132)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4,6-di(2-amino-3-pyridine)-2-pyrimid inyl)amide (1133)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1134)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1135)(L)-2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p nitrophenylhydroxyethyl)]amide (1136)(L)-2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p aminophenylhydroxyethyl)]amide 50 (1 137)2-(2-pyrrolidine- l -yl-5 -pyrimidinyl)- 1H-benzimidazole-4-[N-( 1-methyl-2-p-chloropheny lhydroxyethyl)] amide (113 8)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-N' -piperidinyl)amide (113 9)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-piperazinyl)amide (11 40)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2' -benzimidazolyl)amide (1141 )2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (11 42)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-o-aminophenyl)amide (1 143)2-(2-pyrrolidine- l-yl-5 -pyrimidinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (11 44)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4' -carbonamido-5 '-imida zolyl)amide (1 145 )2-(2-pynnolidine- l-yl-5-pyrintdinyl)- 1H-benzimidazole-4-(N-4'-catboxyl-5 '-imidazolyl)amide (11 46)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-imidazolyl)amide (11 47)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4' -pyrazolyl)amide (11 48)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-(N' -piperazinyl))amide (1 149)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (11 50)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyrazinyl)amide (1151 )2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyrimidinyl)amide (11 52)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1153 )2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-5 -pyrimidinyl)amide (11 54)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyridyl)amide (1155 )2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-3 -pyridyl)amide (115 6)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-5 -pyridyl)amide (11 57)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amiide (115 8)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-5 -thiazolyl)amide (115 9)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimid inyl)amide (11 60)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4,6-di(2-pyrrolidine- 1 yl-S -pyrimidinyl)-2-pyrimidinyl)amide (1161 )2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyri midinyl)amide (11 62)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidin 51 yl)amide (1 163 )(L)-2-(2-piperidine- l -yl-5 -pyrimidinyl)- 1H-benziimidazole-4-[N-(l1-hydroxymethyl-2-p-n itrophenylhydroxyethyl)]amide (1 164)(L)-2-(2-piperidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-( 1-hydroxymethyl-2-p-amii nophenylhydroxyethyl)]amide (1 165 )2-(2-piperidine- 1 -yl-5-pyrimidinyl)- 1H-benziimidazole-4-[N-( 1-methyl-2-p-chlorophenylhy droxyethyl)] amide (1 166)2-(2-piperidine- 1-yl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (11 67)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-piperazinyl)amide (11 68)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2' -benzimidazolyl)amide (11 69)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (11 70)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-o-aminophenyl)amide (1171 )2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (11 72)2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4' -carbonamido-5 '-imidaz olyl)amide (1 173 )2-(2-piperidine- 1-yl-5-pyrimidinyl)- 1H-benziimidazole-4-(N-4'-catboxyl-5 '-imidazolyl)amide (11 74)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-imidazolyl)amide (1175 )2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4' -pyrazolyl)amide (11 76)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-(N' -piperazinyl))amide (1 177)2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (11 78)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyrazinyl)amide (11 79)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyrimidinyl)amide (11 80)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1181 )2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-5 -pyrimidinyl)amide (11 82)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyridyl)amide (1183 )2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-3 -pyridyl)amide (11 84)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-pyridyl)amide (11 85)2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (11 86)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(5 -thiazolyl)amide (11 87)2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidi nyl)amide 52 (1 188)2-(2-piperidine- 1-yl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-di(2-piperidine- 1l-yl-5 pyrimidinyl)-2-pyrimidinyl)amide (1 189)2-(2-piperidine- 1-yl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrim idinyl)amide (1 190)2-(2-piperidine- 1-yl-5-pyrimidinyl)- 1H-benziniidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (119 1)(L)-2-(2-cyclopropylamino-5 -pyrimidinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2 p-nitrophenylhydroxyethyl)]amide (1 192)(L)-2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benziniidazole-4-[N-(l1-hydroxymethyl-2-p aminophenylhydroxyethyl)] amide (1 193 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-[N-( 1-methyl-2-p-chlorophenyl hydroxyethyl)]amide (1 194)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (1 195 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl)amide (1 196)2-(2-cyclopropylamino-5-pyriniidinyl)- 1H-benzimidazole-4-(N-2' -benzimidazolyl)amide (1 197)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1 198)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (11 99)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1 200)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imi dazolyl)amide (1201 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazo lyl)amide (1 202)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (1203 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (1 204)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (1205 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (1 206)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1 207)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (1 208)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1 209)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (121 0)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (1211 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide 53 (121 2)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (12 13)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (121 4)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(5 -thiazolyl)amide (1215 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrim idinyl)amide (121 6)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-di(2-cyclopropylam mno-S -pyrimidinyl)-2-pyrimidinyl)amide (121 7)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-py rimidinyl)amide (121 8)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidi nyl)amide (121 9)(L)-2-( 1,3-dimethyl-5 -chloro-4-pyrazolyl)- 1H-benziniidazole-4-[N-( 1-hydroxymethyl-2 p-nitrophenylhydroxyethyl)]amide (1 220)(L)-2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1H-benziniidazole-4-[N-(l1-hydroxymethyl-2-p-a minophenylhydroxyethyl)] amide (1221 )2-( 1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benziniidazole-4-[N-(1 -methyl-2-p-chlorophenyl hydroxyethyl)]amide (1 222)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (1223 )2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl)amide (1224)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1H-benziniidazole-4-(N-2' -benzimidazolyl)amide (1225 )2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1 226)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (1227)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1H-benziniidazole-4-(N-5-benziniidazolonyl)amiide (1 228)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imid azolyl)amide (1 229)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazol yl)amide (1 230)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (1231 )2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (1 232)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (123 3)2-( 1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benziniidazole-4-(N' -ethyl-N-piperazinyl)amide (1 234)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide 54 (1235)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1236)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1237)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1238)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (1239)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (1240)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (1241)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1242)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(5-thiazolyl)amide (1243)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrim idinyl)amide (1244)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimi dinyl)amide (1245)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyr imidinyl)amide (1246)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidi nyl)amide (1247)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1248)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1249)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1250)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1251)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1252)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1253)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1254)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1255)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1256)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1257)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1258)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1259)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1260)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1261)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 55 (1 262)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrim idinyl)amide (1263 )2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1264)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1265 )2-(2-pyrazinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 266)2-(2-pyrazinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1 267)2-(2-pyrazinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 268)2-N-piperazinyl-l1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1 269)2-N-piperazinyl- 1 H-benzimidazole-4-(N-6-purinyl)amide (1 270)2-N-piperazinyl- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1271 )2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amiide (1 272)2-(4-methyl-5 -aminothiazolyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1273 )2-(4-methyl-5 -aminothiazolyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 274)2-thiazolyl- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1275 )2-thiazolyll- 1 H-benzimidazole-4-(N-6-purinyl)amide (1 276)2-thiazolyl- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1277)5 -thiazolyl- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1278)5 -thiazolyl- 1 H-benzimidazole-4-(N-6-purinyl)amide (1279)5 -thiazolyl- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 280)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1281 )2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1 282)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1283)2-(2-phenyl-5 -pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 284)2-(2-phenyl-5 -pyrimidinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1285 )2-(2-phenyl-5 -pyrimidinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 286)2-(4-amino-6-chloro-5 -pyrimidinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1 287)2-(4-amino-6-chloro-5 -pyrimidinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (128 8)2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 289)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 29O)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide 56 (1291)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1292)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1293)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1294)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1295)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1296)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1297)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1298)2-(2-quinolinyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1299)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1300)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1301)2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1302)2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1303)2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1304)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1305)2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1306)2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1307)2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1308)2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1309)2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1310)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1311)2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1312)2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1313)2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1314)2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1315)2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1316)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1317)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1318)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1319)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1320)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide 57 (1321)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 322)2-methoxy- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1323)2-methoxy- 1H-benzimidazole-4-(N-6-purinyl)amide (1 324)2-methoxy- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1325)2-ethoxy- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 326)2-ethoxy- 1H-benzimidazole-4-(N-6-purinyl)amide (1 327)2-ethoxy- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1328)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 329)2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1330)2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1331)2-pyrazolyl- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1332)2- pyrazolyl -1H-benzimidazole-4-(N-6-purinyl)amide (1333)2- pyrazolyl -1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1334)2-(2'-pyridyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1335)2-(2'-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1336)2-(2'-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1337)2-(3'-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1338)2-(3'-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1339)2-(3'-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1340)2-(4'-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1341)2-(4'-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1342)2-(4'-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1343)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1344)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1345)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1346)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1347)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1348)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1349)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1350)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide; 58 (1351)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1352)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1353)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1354)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1355)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrim idinyl)amide (1356)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1357)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1358)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1359)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1360)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1361)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1362)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1363)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1364)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1365)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1366)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1367)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1368)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1369)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 370)2-(2-pyridyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1371)2-(2-pyridyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1 372)2-(2-pyridyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1373)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 374)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1375)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 376)2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1 377)2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1378)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 379)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 59 (13 80)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1381)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (13 82)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1383)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (13 84)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1385)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (13 86)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (13 87)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (13 88)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (13 89)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1390)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1391)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1392)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1393)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1394)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1395)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1396)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1397)2-(3-indolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1398)2-(3-indolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1399)2-(3-indolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1400)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1401)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1402)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1403)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1404)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1405)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1406)2-(2-bromo-5-pyridine)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1407)2-(2-bromo-5-pyridine)-1H-benzimidazole-4- (N-6-purinyl)amide (1408)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1409)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 60 (1410)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-6-purinyl)amide (1411)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1412)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1413)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1414)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1415)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidin yl)amide (1416)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1417)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1418)2-(2-cyclopropylamino)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1419)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1420)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1421)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimi dinyl)amide (1422)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1423)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1424)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide. Preferably, the pharmaceutically acceptable salts of benzimidazole-4-carboxamide derivatives are inorganic acid salts thereof selected from sulfate, hydrochloride, nitrate, phosphate or boratethe, or organic acid salts thereof selected from citrate, succinate, tartrate, lactate or mesylate. Another purpose of the present invention is to provide anti-cosxackie-viruses pharmaceutical compositions. The pharmaceutical compositions comprise a therapeutically effective amount of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to any one of claims 1 ~ 7, and one or more pharmaceutically acceptable thinner, excipient and/ or inert carrier. A further purpose of the present invention is to provide uses of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts for for preparation of .antivirus medications, wherein the viruses are CoxsackieVirus, echovirus and enterovirus which belong to picomaviridae. Another purpose of the prevent invention is to provide a method of the 61 benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof as shown in Formula (I), comprising the following steps: (1) 2-aminoacetyl-3-nitrobenzoic acid is undergoing reactions of ammonolysis, Hoffman degradation and reduction in turn, to produce 2,3- diamino benzoic acid. (2) 2,3-diamino benzoic acid is condensed with aldehydes X-CHO in the presence of catalyst of cupric acetate, to produce benzimidazole-4-carboxylic acid of Formula (II). OH 0 N N (3) benzimidazole-4-carboxylic acid is reacted with thionyl chloride to produce acyl chloride, and then condensing the acyl chloride and an amine NH 2 -Y, to produce the benzimidazole-4-carboxamide derivative of Formula (I). Y N-H 0 SN (I) The above reaction conditions are as follows: benzimidazole-4-carboxylic acid is reated with thionyl chloride at temperature of 0-80'C in a molar molecular ratio of thionyl chloride to benzimidazole-4-carboxylic acid is 1-20 times, to produce benzimidazole-4-carbonyl chloride, and then benzimidazole-4-carbonyl chloride is reacted with an amine in an organic solvent at temperature of 0-100'C to produce benzimidazole-4-carboxamide derivatives. Wherein the organic solvent comprises dichloroethane, 1,1,2-trichloroethane, chloroform, tetrachloroethylene, benzene, toluene, xylene, chlorobenzene or dichlorobenzene, and so on. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof of the present invention may be administered orally or not. The dosage varies with different drugs, the dosage is 10-300 mg per day in general conditions. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 shows 1 HNMR spectrogram of 2-(2,3,4-trihydroxyphenyl)-1H- benzimidazole 62 -4-carboxylic acid in Example 9. Fig. 2 shows 1 HNMR spectrogram of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4 -(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl))amide in Example 21. Fig. 3 shows 1 HNMR spectrogram of 2-(5-nitro-2-thienyl)-1H-benzimidazole -4-(N-o-fluorophenyl)amide in Example 28. Fig. 4 shows 1 HNMR spectrogram of (L)-2-(2-pyridyl)-1H-benzimidazole-4-(N-(1 hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide in Example 194. Fig. 5 shows 1 HNMR spectrogram of 2-(4-hydroxyphenyl)-1H- benzimidazole-4-(N o-fluorophenyl)amide in Example 663. Fig. 6 shows 1 HNMR spectrogram of (L)-2-(3-hydroxyphenyl)-1H-benzimidazole -4-(N- (1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide in Example 664. DETAILED DESCRIPTION OF THE PRESENT INVENTION AND PREFERRED EMBODIMENTS THEREOF Hereafter, the present invention will be described specifically with reference to examples. The examples are given only for illustration of the technical solution of the present invention and should not be construed to limit the present invention. The method of preparing for benzimidazole-4-amide derivatives of the present invention is as follows: using 2-aminoacetyl-3-nitrobenzoic acid as an initiating raw material, 2-aminoacetyl-3-nitrobenzoic acid in turn is undergoing ammonolysis, Hoffman degradation and reduction, to produce 2,3- diamino benzoic acid; and then condensing 2,3-diamino benzoic acid and aldehydes X-CHO in the presence of catalyst of cupric acetate, to produce benzimidazole-4-carboxylic acid; and then reacting benzimidazole-4-carboxylic acid with thionyl chloride to produce acyl chloride, and then condensing the acyl chloride and an amine NH 2 -Y, to produce the benzimidazole-4-carboxamide derivative. Example 1: Synthesis of 2.3-diamino benzoic acd Step 1: Synthesis of 2-aminoacetyl-3-nitrobenzoic acid 30g of 3-nitro phthalic anhydride is added into 45ml of concentrated ammonia with 28g/g% concentration; and heat it to 60'C under stirring for 30 minutes; and then to cool it to 10'C till precipitate needle shape crystals; and to acidize the needle shape crystals with concentrated chlorhydric acid to produce white solids; and then to filter and dry it to obtain 63 29.4g of 2-aminoacetyl-3-nitrobenzoic acid. Step 2: Synthesis of 2-amino-3-nitrobenzoic acid 13.9g of bromine is dropped into 100ml of sodium hydroxide aqueous-solution containing 7.3g of sodium hydroxide to a solution. Then 17 g of 2-aminoacetyl-3 nitrobenzoic acid is added into the above solution; and to heat it to 80'C to precipitate a large amount of red solids; to filter and then acidize it with the concentrated chlorhydric acid to produce yellow solid products; to dry it to obtain 13.7g of 2-amino-3-nitrobenzoic acid; and then recrystallize the yellow solid products by adding hot water to obtain the yellow needle shape crystals. Step 3: Synthesis of 2,3-diaminobenzoic acid 3g of the above mentioned 2-amino-3-nitrobenzoic acid is added into 30ml of methanol, 20% sodium hydroxide aqueous solution with the same molar as 2-amino-3-nitrobenzoic acid is dropped into the above methanol solution till dissolv e completely. 0.2g of Raney nickel at the moment is added in to the methanol solution, and to heat it to 65 C and reflux it at the temperature; and then drop 80g/g% hydrazine hydrate (about 1.5 equivalent weight x 1.1) till the yellow disappears completely. Hot Raney nickel is filtered; and then heat and concentrate the mother liquid and acidize it with the concentrated chlorhydric acid to produce 2.3g of red 2,3-diaminobenzoic acid; afterwards isolate and purify the crude product of red 2,3-diaminobenzoic acid by column chromatography . Example 2: Synthesis of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4- carboxylic acid 2.Og of 2,3-diaminobenzoic acid is dissolved into 60ml of methanol, and methanol solution of 5-nitrofurfural is added into the methanol under stirring. Then 0.5g of cupric acetate (Cu(Ac) 2
-H
2 0) is added into the above methanol, and then to heat and reflux it; and then to filter hot solution after 2,3-diaminobenzoic acid disappears. 20% sodium sulfide aqueous solution is added into the filtrate and heat it till boiling; and then filtrate the copper sulfide deposition while it is hot; and then to evaporate the filtrate to dry, purify it through column chromatography to obtain 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid. The yield is about 65%.
64 Examples 3-20: synthesis of intermediates of benzimidazole-4- carboxylic acid Synthesize the benzimidazole-4- carboxylic acid as shown in Formula (II) according to the method of Example 2. The difference is to use aldehydes with different X group as listed in Table 1. OH 0 N X N Table 1 No. of Products Compounds X Yield% 4 2-(2-pyrimidinyl)-1H-benzimidazole-4-ca C N 75 rboxylic acid N 5 2-(2-thienyl)- 1H-benzimidazole-4- 76 carboxylic acid 6 2-methyl- 1H-benzimidazole-4- -CH3 72 carboxylic acid 7 2-phenyl-1H-benzimidazole-4- 80 carboxylic acid 8 2-(4-(dimethylamino)-phenyl)- 1H- 75 benzimidazole-4-carboxylic acid CH3 NCH 3 9 2-(2,3,4-trihydroxyphenyl)-1H- 65 benzimidazole-4-carboxylic acid 10 2-(4-methoxy-2-pyridyl)-1H- N 68 65 benzimidazole-4-carboxylic acid 11 2-(6-methoxy-2-pyridyl)- 1H- 70 benzimidazole-4-carboxylic acid OCH 3 12 2-(4-(dimethylamino)-2-pyridyl)- 1H- N 75 benzimidazole-4-carboxylic acid N
CH
3 ' CH 3 13 2-(3-pyridazinyl)-1H- benzimidazole 60 -4-carboxylic acid N 14 2-(2-piperazinyl)-1H- benzimidazole 61 -4-carboxylic acid 15 2-(5-amino-4-methyl-2-thiazolyl)- 1H- CH 3 70 benzimidazole-4-carboxylic acid NH2 16 2-(3-quinolinyl)-1H- benzimidazole 63 -4-carboxylic acid 17 2-(2-pyrrolyl)-1H- benzimidazole N 75 -4-carboxylic acid 18 2-(3-indolyl)-1H- benzimidazole NH 71 -4-carboxylic acid 19 2-(2-piperidinyl)-1H- benzimidazole 68 -4-carboxylic acid 20 2-(2-quinolinyl)-1H- benzimidazole 70 -4-carboxylic acid N Structure Identification of Products: (4) 2-(2-pyrimidinyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.67-7.80(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.09(d,1H), 9.10-9.12(d,1H); (5) 2-(2-thienyl)-1H-benzimidazole-4-carboxylic acid 66 HNMR (DMSO, 400MHz) 6: 7.15-7.18(t,1H), 7.41-7.45(t,1H), 7.68-7.70(d,1H), 7.85(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (6) 2-methyl-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 2.51(s,3H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (7) 2-phenyl-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 7.41-7.45(t,1H), 7.38-7.42(t,1H) 7.50-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.30(d,2H); (8) 2-(4-(dimethylamino)-phenyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 3.06(s,6H) 6.82-6.84(d,2H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.97-7.99(d,2H); (9) 2-(2,3,4-trihydroxyphenyl)-1H-benzimidazole-4-carboxylic acid (refer to Figure 1) 1 HNMR (DMSO, 400MHz) 6: 6.43-6.46 (d, 1H), 7.28-7.32 (t, 1H), 7.77-7.79 (d, 1H), 7.82-7.85 (m, 1H), 8.57(s, 1H), 9.54 (s, 1H), 12.11(s, 1H), 13.16(s, 1H); (10) 2-(4-( methoxy)-2-pyridyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,1H), 7.41-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.48-8.49(d,1H); (11) 2-(6-methoxy-2-pyridyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 3.80(s,3H), 6.50-6.51(d,1H), 7.38-7.39(d,1H), 7.41-7.45(t,1H), 7.72-7.75(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (12) 2-(4-(dimethylamino)-2-pyridyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 7.16-7.18(d,1H), 7.41-7.45(t,1H), 7.71(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.05-8.07(d,1H); (13) 2-(3-pyridazinyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 7.41-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.06-8.08(d,1H), 9.34-9.37(d,1H); (14) 2-(2-piperazinyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,2H), 2.60-2.62(m,1H), 2.65-2.66(m,1H), 2.67-2.70(m,1H), 2.72-2.75(m,1H), 2.84-2.88(m,1H), 3.09-3.14(m,1H), 4.14-4.19(m,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (15) 2-(5-amino-4-methyl-2-thiazolyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 1.03-1.09(d,3H), 3.70-3.73(m,1H), 4.17-4.22(m,1H), 5.11-5.13(d,2H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); 67 (16) 2-(3-quinolinyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 7.41-7.45(t,1H), 7.60-7.65(t,1H), 7.78-7.80(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.97-7.99(d,1H), 8.06-8.09(d,1H), 8.22(s,1H), 8.57(s,1H); (17) 2-(2-pyrrolyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 6.15-6.17(t,1H), 6.39-6.40(d,1H), 6.95-6.98(t,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (18) 2-(3-indolyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 7.01-7.05(t,1H), 7.31-7.34(t,1H), 7.41-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60(s,1H); (19) 2-(2-piperidinyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 1.47-1.49(m,2H), 1.50-1.55(m,2H), 1.67-1.92(m,2H), 4.01-4.03(m,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (20) 2-(2-quinolinyl)-1H-benzimidazole-4-carboxylic acid 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.46-1.47(m,1H), 1.49-1.51(m,1H), 1.53-1.55(m,1H), 1.67-1.70(m,1H), 1.92-1.96(m,1H), 2.69-2.71(m,1H), 2.78-2.80(m,1H), 4.01-4.03(m,1H), 7.41-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H)o Example 21: Synthesis of (L)-2-(5-nitro-2-thienyl)-1H-benzimidazole-4 (N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)amide 1.0g of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-carboxylic acid in Example 2 is added into 15ml of thionyl chloride and is reacted for 60 minutes, after end of the reaction completely, (L)-2-amino-1-p-nitrophenyl-1,3-propylene glycol (1.leq.) is added into the reaction mixture under stirring for 2 hours at the room temperature; and then filter the inorganic salt, evaporate the solvent to dry and obtain the final product of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxyet hyl)amide. The yield is about 93%. 1 HNMR spectrum is shown in Figure 2 Structure Identification of Product: 1 HNMR(DMSO,400MHz)6:3.59-3.60(m, 1H),3.65-3.67(t, 1H),4.16-4.22(q, 1H),5.07-5. 08(t, 1H),5.27-5.28(t, 1H),6.16-6.17(d, 1H),7.35-7.39(t, 1H),7.53-7.54(d, 1H),7.72-7.75(m,2H ),7.77-7.79(m,2H),8.00-8.01(d, 1H),8.05-8.07(d,3H), 10.04-10.06(d,2H), 14.05(s, 1H) Example 22: Synthesis of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-(1-methyl 68 -2-p-chlorophenylhydroxyethyl)amide 1.0g of 2-(5-nitro-2-thienyl)-1H-benzimidazole-4- carboxylic acid is added into 15ml of thionyl chloride; and to heat and reflux it for 60 minutes. After end of the reaction, 2-amino-1-p-chlorophenyl-1-propanol (1.leq) is dissolved into tetrahydrofuran, and then drop acyl chloride to the above tetrahydrofuran mixture under stirring at the room temperature and then filter inorganic salt, evaporate the solvent to dry, and then isolate the mixture through column chromatography to obtain 2-(5-nitro-2-thienyl)-1H-benzimidazole 4-(N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl) amide. The yield is about 92%. Structure Identification of Product: 1 HNMR (DMSO, 400MHz) 6: 1.10-1.16(d,3H), 3.26-3.28(m,1H), 3.64-3.66(d,1H), 4.71-4.74(m,1H), 7.28-7.30(d,2H), 7.35-7.38(d,2H), 7.41-7.45(t,1H), 7.56-7.58(d,1H), 7.62-7.68(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H)o Examples 23-67: Use the same process as Example 22 to synthesize the compound as shown in Table 2. 0 N &NH Table 2 No. Compounds X YField 2-(2-pyridyl)- 1H-benzimidazole-4-N N 23 HHC2H 8 -hydroxyethylamide \/NHCH2CH2OH 88 OH 24 2-(2-pyridyl)- 1H-benzimidazole-4-N -NH OH -o-hydroxyphenylcarboxylamide / OH F 25 2-(2-hydroxyphenyl)-1H-benzimida 82 zole-4-(N-o-fluorophenyl)amide 69 (L) -2- (2-hydroxyphenyl) - 1 H-benzim OH
H
2 H H 26 idazole- 4- [N- (1-hydroxyl -2-p -nitrop 7H 91 henylhydroxyethyl)] amide HO NH H OH 27 2-(5 -nitro -2-thienyl) - 1 H-benzimidaz 90 -N2 N N 9 H H 28 2-(5 -nitro-2-thienyl)-l1H-benzimidaz
NQ
2 -NHb 89 28ole-4-(N-o-fluorophenyl)amide\ / 29 2-(3,4,5-trihydroxyphenyl)- 1H-benzi _H9 midazole-4-(N-o-fluorophenyl)amide OH) OHt OHt 30 2-(3 ,4,5 -trihydroxyphenyl)-l1H-benzi I -- NHCH2CH2OH 86 midazole-4-(N-hydroxyethyl)amide OH) OHt OHt 31 2-(2-piperidinyl)- 1H-benzimidazole- /, H 3 9 4-(4-N' -ethyl-N-piperazinyl)amide 32 2-(2-pyridyl)- 1 H-benzimidazole-4-( N-H 4-N'-ethyl-N-piperazinyl)amide \/ (L)-2-(2,6-dimethyl-2,6-octadienyl)- H H2 H 33 1H-benzimidazole-4-[N-(1-hydroxy H 90 methyl-2-p-nitrophenylhydroxyethyl NH )amide H3C C3HO / H 70 CH H 2 N N (L)-2-(2,6-dimethyl-2,6-octadienyl)- -H OH 34 1H-benzimidazole-4-[N-(l1-hydroxy H 89 methyl-2-p-aminophenylhydroxyeth I H NH ____yl)] amide /3 HH 2-(2,6-dimethyl-2,6-octadienyl)- 1H- S .IH 35 benzimidazole-4- [N-(l1-methyl-2-p-c C, 90 hlorophenylhydroxyethyl)] amide HC CsHO NH CH, H 2-(2,6-dimethyl-2,6-octadienyl)- 1H- N 36 benzimidazole-4-(N-N' -piperidinyl) N90 amide HCs -C3C CH3 H 2-(2,6-dimethyl-2,6-octadienyl)-l1H- ~HN *_N) 37 benzimidazole-4-(N-2-piperazinyl)a 89 mide H H3C CH3 CH 2-(2,6-dimethyl-2,6-octadienyl)-1H- -. K~ H 38 benzimidazole-4-(N-2' -benzimidazo '91 ZN lyl)amide H HC CH3 CH3 2-(2,6-dimethyl-2,6-octadienyl)-1H-N 39 benzimidazole-4-(N-o-aminophenyl) 88 amide 7 H H3Cs C,~ CH, 2-(2,6-dimethyl-2,6-octadienyl)-1H- N 40 benzimidazole-4-(N-5- >=o 87 benzimidazolonyl)amide HH HC CH3 CH3 H 2-(2,6-dimethyl-2,6-octadienyl)-l1H-N 41 benzimidazole-4-(N-4'-carbonamido H2N 90 -5' -imidazolyl)amide H H3C CH3 0 71 CH3 H N -- N 2-(2,6-dimethyl-2,6-octadienyl)- 1H- I 42 benzimidazole-4-(N-4' -pyrazolyl) C / 87 amide NH IH3C CH3 N CH3 2-(2,6-dimethyl-2,6-octadienyl)- 1 H 43 benzimidazole-4-(N-(N'-piperazinyl N___\- NH 87 ))amide HCs C CH3 2-(2,6-dimethyl-2,6-octadienyl)- 1 H- N 44 benzimidazole-4-(N-2-pyrazinyl) IJ90 amide "N N) HC CH
SCH
3 2-(2,6-dimethyl-2,6-octadienyl)- 1H-N 45 benzimidazole-4-(N-2-pyrimidinyl)a 91 mide H'O HC CH 3 SCH 46 2-(2,6-dimethyl-2,6-octadienyl)- 1H-b 9 46 enzimidazole-4-(N-2-pyridyl)amide Nl H H3C CH SCH 2-(2,6-dimethyl-2,6-octadienyl)- 1 H- N 47 benzimidazole-4-(N-4-methyl-5-thia 90 zolyl)amideH
H
3 C CH 3 CH3 2-(2,6-dimethyl-2,6-octadienyl)- 1 H- HO H 48 benzimidazole4(N-24-dihydroxyl- O< 85 5 -pyrimidinyl)amide 3 CH CH3
OCH
3 2-(2,6-dimethyl-2,6-octadienyl)- 1 H- N H 49 benzimidazole-4-(N-4,6-dimethoxy- N - / 94 2-pyrimidinyl)amide HC CH, CH CH3 CI 2-(2,6-dimethyl-2,6-octadienyl)- 1 H- N H 50 benzimidazole-4-(N-4-chloro-6-ami yN\ /8 no-2-pyrimidinyl)amide H3C CH3 NH 2 72 CHC cI 2-(2,6-dimethyl-2,6-octadienyl)- 1H- N9 51 benzimidazole-4-(N-4,6-dichloro-5- 90 pyrimidinyl)amide N cI H3C CH3 CH, 2-(2,6-dimethyl-2,6-octadienyl)- 1H- N 52 benzimidazole-4-(N-o-fluorophenyl) 93 amide F H3C CH CH3 2-(2,6-dimethyl-2,6-octadienyl)- 1H- NH 53 benzimidazole-4-(N-2-hydroxyl-4-p N 86 yrimidinyl)amide H3C CH HO N CH3 54 2-(2,6-dimethyl-2,6-octadienyl)- 1H-b NH 90 enzimidazole-4-(N-6-purinyl)amide N HC CH3 N CH3 OH 2-(2,6-dimethyl-2,6-octadienyl)- 1H 55 benzimidazole-4-(N-6-hydroxy-2-pu N N 91 rinyl)amide -N N N H3C CH, H H 0 2 N H S H (L)-2-(2-thienyl)- 1H-benzimidazole- H OH H 4-[N-(1-hydroxymethyl-2-p-nitrophe NH nylhydroxyethyl)]amide H2N (L)-2-(2-thienyl)- 1H-benzimidazole- s 'a HOH 57 4-[N-(1-hydroxymethyl-2-p-aminop H henylhydroxyethyl)]amide H NH H HO. H 2-(2-thienyl)-1lH-benzimidazole-4-[ H 58 N-(1-methyl-2-p-chlorophenylhydro CH3 92 xyethyl)]amide HO NH H S N 59 2-(2-thienyl)- 1 H-benzimidazole-4-( N 91 N-N'-piperidinyl)amide \ / 73 H 60 2-(2-thienyl)- 1 H-benzimidazole-4-( HN N N-2-piperazinyl)amide N H 61 2-(2-thienyl)- 1 H-benzimidazole-4-( \ 93 N-2'-benzimidazolyl)amide / N H 2 2-(2-thienyl)-1H-benzimidazole-4-( N-o-aminophenyl)amide /4 63 2-(2-thienyl)- 1 H-benzimidazole-4-( e 90 N-5- benzimidazolonyl)amide H 64 2-(2-thienyl)- 1H-benzimidazole-4-(N- H2N N 4'-carbonamido-5'-imidazolyl)amide / 0H s N N 65 2-(2-thienyl)- 1 H-benzimidazole-4-( 92 N-4'-pyrazolyl)amide \ NH 66 2-(2-thienyl)- 1 H-benzimidazole-4-( NH 94 N-(N'-piperazinyl))amide \ / N 67 2-(2-thienyl)- 1H-benzimidazole-4-( 9 N-2-pyrazinyl)amide N 2-(2-thienyl)-1H-benzimidazole-4-( 68N-2-pyrimidinyl)amide N3 H 2-(2-thienyl)-1H-benzimidazole-4-( 68 N-2-pyridyl)amideide / H 2-(2-thienyl)-1H-benzimidazole-4-( S 70 N-4-methyl-5-thiazolyl)amide 74
N
H 2-(2-thienyl)- 1 H-benzimidazole-4-( s HO 71 N-2,4-dihydroxyl-5-pyrimidinyl)ami N 93 de N7 OH
OCH
3 72 2-(2-thienyl)- 1H-benzimidazole-4-(N S N -4,6-dimethoxy-2-pyrimidinyl)amide \
OCH
3 CI 2-(2-thienyl)- 1 H-benzimidazole-4-( s 73 N-4-chloro-6-amino-2-pyrimidinyl) \ /\ 88 amideN/
NH
2 CI 2-(2-thienyl)-1 H-benzimidazole-4-( N- H 74 N-4,6-dichloro-5-pyrimidinyl)amide \ N 89 CI 75 2-(2-thienyl)-1H-benzimidazole-4-( 87 N-o-fluorophenyl)amide 'F 76 2-(2-thienyl)- 1 H-benzimidazole-4-( 9Z N-2-hydroxyl-4-pyrimidinyl)amide N HO- N sL 77 2-(2-thienyl)- 1 H-benzimidazole-4-( N 90 N-6-purinyl)amide N N OH 78 2-(2-thienyl)- 1 H-benzimidazole-4-( NO N 91 N-6-hydroxyl-2-purinyl)amide N N N H H (L)-2-(4-methoxypyridyl)- 1H-benzi N2N H OH 79 midazole-4-[N-(1-hydroxymethyl-2- H 93 p-nitrophenylhydroxyethyl)] amide OCH 3 HO H
H
2 N H O (L)-2-(4-methoxypyridyl)- 1H-benzi N- H OH H 80 midazole-4-[N-(1-hydroxymethyl-2- H NH H 93 p-aminophenylhydroxyethyl)]amide OCH3 75 CI 2-(4-methoxypyridyl)- 1H-benzimida N-N H 81 zole-4- [N-(l1-methyl-2-p-chlorophen ) N CH3 94 ylhydroxyethyl)] amide OCH3 HO N- H 82 2-(4-methoxypyridyl)- lHbenzimida \ ~N 90 zole-4-(N-N' -piperidinyl)amide
OCH
3 N- _HN, N 83 2-(4-methoxypyridyl)- 1H-benzimida \ / - 93 83 zole-4-(N-2-piperazinyl)amide _q/ N OCH3 H N ~ N H 84 2-(4-methoxypyridyl)- 1H-benzimida 92 zole-4-(N-2' -benzimidazolyl)amide (:: N
OCH
3 H N-H 2-(4-methoxypyridyl)- 1H-benzimida a 85 \1 91 zole-4-(N-o-aminophenyl)amide
OCH
3 NH N-H 86 2-(4-methoxypyridyl)- 1 H-benzimida 91 zole-4-(N-5 -benzimidazolonyl)amide OCHN HC H 2-(4-methoxypyridyl)- 1H-benzimida
N
87 zole-4-(N-4'-carbonamido-5'-imidaz \/H2N IN 9 H olyl)amide OCH 3 0H
N
88 2-(4-methoxypyridyl)- 1H-benzimida \/I/92 zole-4-(N-4' -pyrazolyl)amide OCH3 NH 2-(4-methoxypyridyl)- 1H-benzimida H 89 zole-4-(N-(N' -piperazinyl))amide OCH, NH9 N- N 90 2-(4-methoxypyridyl)- 1H-benzimida \/9 90 zole-4-(N-2-pyrazinyl)amide -P N N 9
OCH
3 H _qN 91 2-(4-methoxypyridyl)- 1H-benzimida \9/ zole-4-(N-2-pyrimidinyl)amide N N9
OCH
3
H
76 922-(4-methoxypyridyl)- 1H-benzimida \N 9 zole-4-(N-2-pyridyl)amideN o
OCH
3 H N- CH 3 93 2-(4-methoxypyridyl)- 1H-benzimidaz 9 ole-4-(N-4-methyl-5 -thiazolyl)amide N
OCH
3 S H 2-(4-methoxypyridyl)- 1H-benzimida N-Z H 94 zole-4-(N-2,4-dihydroxyl-5-pyrimidi HO ... 94 nyl)amide )H 2-(4-methoxypyridyl)- 1H-benzimida N-N OCH3 N 90 95 zole-4-(N-4,6-dimethoxy-2-pyrimidi \/ "H _< / nyl)amide OCH 3 H cI 2-(4-methoxypyridyl)- 1H-benzimida N H 96 zole-4-(N-4-chloro-6-amino-2-pyrim \ N-\ /94 idinyl)amide OCH3 NzNH2 2-(4-methoxypyridyl)- 1H-benzimida N 97 zole-4-(N-4,6-dichloro-5-pyrimidiny N 92 1)amide
OCH
3 N N-H 98 2-(4-methoxypyridyl)- 1H-benzimida \ N9 zole-4-(N-o-fluorophenyl)amide OCH3 2-(4-methoxypyridyl)- 1H-benzimidaN 99 zole-4-(N-2-hydroxyl-4-pyrimidinyl I 94 )amide OCH 3
N
102-(4-methoxypyridyl)- 1H-benzimida \ ~N93 10zole-4-(N-6-purinyl)amide OCQ/ OCH3 OH 112-(4-methoxypyridyl)- 1H-benzimidaz N /N 90 ole-4-(N-6-hydroxyl-2-purinyl)amide
OCH
3 -N N N H H 12(L)-2-(6-methoxypyridyl)- 1H-benzi Nil, H H 9 12midazole-4- [N-(l1-hydroxymethyl-2- 9 p-nitrophenylhydroxyethyl)]amide OCH3 HO pHH 77 (L)-2-(6-methoxypyridyl)- 1 H-benzi (:I H O HNO 103 midazole-4- [N-(l1-hydroxymethyl-2- NH H 93 p-aminophenylhydroxyethyl)]amide OCH3 HO NHH ci 2-(6-methoxypyridyl)- 1H-benzimida H 104 zole-4- [N-(l1-methyl-2-p-chlorophen N IHH, 9 ylhydroxyethyl)]amide OC ~HO NH H NN 15zole-4-(N-N'-piperdinyl)amide 9 OCH3 H 16 2-(6-methoxypyridyl)- 1H-benzimida '1NN 89" N 16zole-4-(N-2-piperazinyl)amide NCH 89 N OCH3 2-(6-methoxypyridyl)- 1H-benzimida N ole-4-(N--benzimidazolyl)amide IN NH
OCH
3 H H NN 192-(6-methoxypyridyl)- 1H-benzimiida "C C 8=90 11 ole-4-(N-'-carboniamio-5'aimidaz N2 olylamiN H
OCH
3 H H 2-(6-methoxypyridyl)- 1 H-benzimida NN 111 zole-4-(N-4' -pyraolyamide'iia H 9 OC N ol-(6-miethxyyrdy)-H-eniH H 112 zole-4-(N-('-pipraziyl)amide N-NH 93
OCH
3 78 N 132-(6-methoxypyridyl)- 1H-benzimida N 94 13zole-4-(N-2-pyrazinyl)amide N N9 OCH3 114 2-(6-methoxypyridyl)- 1H-benzimida NNN9 zole-4-(N-2-pyrimidinyl)amide 9 N N' H OCH3 115 2-(6-methoxypyridyl)- 1H-benzimida ~N N - 9 zole-4-(N-2-pyridyl)amide Nj , H
OCH
3 NH 162-(6-methoxypyridyl)- 1H-benzimidaz N 9 16ole-4-(N-4-methyl-5 -thiazolyl)amide (39
OCH
3 S H 2-(6-methoxypyridyl)- 1H-benzimida N H 117 zole-4-(N-2,4-dihydroxyl-5-pyrimidi HO N 86 nyl)amide OCH3 O OCH3 2-(6-methoxypyridyl)- 1H-benzimida N N H 118 zole-4-(N-4,6-dimethoxy-2-pyrimidi NN-<\ 91 nyl)amide OCH3 N OZCH, cI 2-(6-methoxypyridyl)- 1H-benzimida N-... N H 119 zole-4-(N-4-chloro-6-amino-2-pyrim N-1 N-\9 idinyl)amide 903 H 2-(6-methoxypyridyl)- 1H-benzimida N / H 120 zole-4-(N-4,6-dichloro-5-pyrimidiny -N/ 92 1)amide
OCH
3 N zc OCH~ F 2-(6-methoxypyridyl)- 1H-benzimida N 122 zole-4-(N-2-hydroxyl-4-pyrimidinyl N 87 )aiez-OCH 3 HO ' N 79 H 123 2-(6-methoxypyridyl)- 1H-benzimida N zole-4-(N-6-purinyl)amide N
OCH
3 N N OH 124 2-(6-methoxypyridyl)- 1H-benzimidaz N N 88 ole-4-(N-6-hydroxyl-2-purinyl)amide N OCH N
O
3 H H (L)-2-(4-dimethylaminopyridyl)- 1H- 02N H 125 benzimidazole-4-[N-(1-hydroxymet N H OHH 8 hyl-2-p-nitrophenylhydroxyethyl)]a N H3 H "NHO H mide H 5 HH (L)-2-(4-dimethylaminopyridyl)- 1H- H2N H N6 H* OH 126 benzimidazole-4-[N-(1-hydroxymet N H H hyl-2-p-aminophenylhydroxyethyl)] N CH NH9 amide H HO H -3 ciH 2-(4-dimethylaminopyridyl)- 1H-ben N H 127 zimidazole-4-[N-(1-methyl-2-p-chlo CH CH 90 rophenylhydroxyethyl)]amide H OH NH CHHO H NN 128 2-(4-dimethylaminopyridyl)-1H-benzi N N 94 midazole-4-(N-N'-piperidinyl)amide N C3 H 192-(4-dimethylaminopyridyl)- 1H-benzi C3H CN9 130 i idazo-4-(N-2-piperazinyl)amide N aH H OH3 2-(4-dimethylaminopyridyl)- 1H-ben N 130 zimidazole-4-(N-2'-benzimidazolyl) - xCH3 94 amide IH OH3 80 2-(4-dimethylaminopyridyl)-1H-benzi NK midazole-4-(N-o-aminophenyl)amide N CH3
NH
2 2-(4-dimethylaminopyridyl)- 1H-ben N 132 zimidazole-4-(N-5-benzimidazolony N H CH3 O 1)amide IHH OH3 H N N 2-(4-dimethylaminopyridyl)- 1H-ben N N 133 zimidazole-4-(N-4'-carbonamido-5'- H2N 6 imidazolyl)amide CHH
CH
3 0 H N N 134 2-(4-dimethylaminopyridyl)-1H-ben 91 zimidazole-4-(N-4'-pyrazolyl)amide "N CH HI NH OH3 2-(4-dimethylaminopyridyl)- 1H-ben N H 135 zimidazole-4-(N-(N'-piperazinyl)) CH N--N NH 93 amide
CH
3 N 136 2-(4-dimethylaminopyridyl)- 1H-ben N 93 zimidazole-4-(N-2-pyrazinyl)amide NN CH N N I 1 H
GH
3 H 137 2-(4-dimethylaminopyridyl)-1H-benzi N N 88 midazole-4-(N-2-pyrimidinyl)amide N CH3 N 88 HI H
-H
3 138 2-(4-dimethylaminopyridyl)- 1H-ben N N 8 zimidazole-4-(N-2-pyridyl)amide N "CH3 N HI H
OH
3 2-(4-dimethylaminopyridyl)- 1H-ben N CH3 139 zimidazole-4-(N-4-methyl-5-thiazol N CH3( 87 yl)amide
OH
3 81 2-(4-dimethylaminopyridyl)- 1H-ben N HO H N 140 zimidazole-4-(N-2,4-dihydroxyl-5-p OH 3 88 yrimidinyl)amide OH OH0
OCH
3 2-(4-dimethylaminopyridyl)- 1H-ben N_ I H 141 zimidazole-4-(N-4,6-dimethoxy-2-p CH3 N\ 90 yrimidinyl)amide N
OH
5
OCH
3 CI 2-(4-dimethylaminopyridyl)- 1H-ben N I H 142 zimidazole-4-(N-4-chloro-6-amino-2 CH3 N 89 -pyrimidinyl)amide N
OH
5
NH
2 CI 2-(4-dimethylaminopyridyl)- 1H-ben NN 143 zimidazole-4-(N-4,6-dichloro-5-pyri CH3 N /3 midinyl)amide N
OH
5 H 144 2-(4-dimethylaminopyridyl)-1H-benzi N C K midazole-4-(N-o-fluorophenyl)amide X N "CH3 a
H
3 F 2-(4-dimethylaminopyridyl)- 1H-ben NH 145 zimidazole-4-(N-2-hydroxyl-4-pyri CHN 88 midinyl)amide N N8
CH
3 HO N 146 2-(4-dimethylaminopyridyl)- 1H-ben N H 90 zimidazole-4-(N-6-purinyl)amide 6H3 N N 9
OH
3 H OH 2-(4-dimethylaminopyridyl)- 1H-ben N 147 zimidazole-4-(N-6-hydroxyl-2-purin CH N N yl)amide -- N N N
OH
3 H H Om 3 Om 3 0 2 N (L)-2-(2,3,4-trimethoxyphenyl)-1H- _ H OH 148 benzimidazole-4-[N-(1-hydroxymet OCH 3 H 92 hyl-2-p-nitrophenylhydroxyethyl)] HO NH H amide 82 (L)-2-(2,3,4-trimethoxyphenyl)-1H- 0CH3 Om3 H2N H 149 benzimidazole-4-[N-(1-hydroxymet OCH3 H OH hyl-2-p-aminophenylhydroxyethyl)] NH amide HO H Om3 0m3 clH 2-(2,3,4-trimethoxyphenyl)- 1H-benz H 150 imidazole-4-[N-(1-methyl-2-p-chlor OCH3 CH3 91 ophenylhydroxyethyl)]amide HO [H 0043 0043 H 2-(2,3,4-trimethoxyphenyl)- 1H-benzi O CN 151 midazole-4-(N-N'-piperidinyl)amide / 49 003 003 H 152 2-(2,3,4-trimethoxyphenyl)- 1H-benz OCH3 HN N 9Z imidazole-4-(N-2-piperazinyl)amide H 0043 0043 2-(2,3,4-trimethoxyphenyl)- 1H-benz '.N H 153 imidazole-4-(N-2'-benzimidazolyl) OCH3 93 amide N H OCH Om 154 2-(2,3,4-trimethoxyphenyl)-1H-benzi OCH3 90 midazole-4-(N-o-aminophenyl)amide / aNH2 OCH3 003 2-(2,3,4-trimethoxyphenyl)- 1H-benz 155 imidazole-4-(N-5-benzimidazolonyl) OCH3 92 amide H 2-(2,3,4-trimethoxyphenyl)- 1H-benz N 156 imidazole-4-(N-4'-carbonamido-5'-i OCH3 H2N N 87 midazolyl)amide H 0 H 003 003 N - N 157 2-(2,3,4-trimethoxyphenyl)-1H-benz OCH3 93 imidazole-4-(N-4'-pyrazolyl)amide \/ NH OCH3 003 2-(2,3,4-trimethoxyphenyl)- 1H-benz H 158 imidazole-4-(N-(N'-piperazinyl)) OCH3 N-N N H 94 amide 83 OCH3 OCH3 159 2-(2,3,4-trimethoxyphenyl)- 1H-benz OCH3N 90 imidazole-4-(N-2-pyrazinyl)amide N OCH3 Om3 160 2-(2,3,4-trimethoxyphenyl)- 1H-benz OCH3 94 imidazole-4-(N-2-pyrimidinyl)amide N 0043 0043 161 2-(2,3,4-trimethoxyphenyl)- 1H-benz OCH3 Nt imidazole-4-(N-2-pyridyl)amide 0043 0043OH 2-(2,3,4-trimethoxyphenyl)- 1H-benz ~_N CH3 162 imidazole-4-(N-4-methyl-5-thiazolyl \ / OCH3 94 )amide OCH3 003 2-(2,3,4-trimethoxyphenyl)- 1H-benz _H 163 imidazole-4-(N-2,4-dihydroxyl-5-py OCH3 HO N N94 rimidinyl)amide H 0043 003 OCH 3 2-(2,3,4-trimethoxyphenyl)- 1H-benz N H 164 imidazole-4-(N-4,6-dimethoxy-2-py OCH3 N 93 rimidinyl)amide N
OCH
3 Om3 Om3 ci 2-(2,3,4-trimethoxyphenyl)- 1H-benz _ 165 imidazole-4-(N-4-chloro-6-amino-2- OCH3 N 90 pyrimidinyl)amide N NH2 003 003 C 2-(2,3,4-trimethoxyphenyl)- 1H-benz N_ 166 imidazole-4-(N-4,6-dichloro-5-pyri OCH3 N 91 midinyl)amide NZ C OCH3 003 167 2-(2,3,4-trimethoxyphenyl)-1H-benzi OCH3 93 midazole-4-(N-o-fluorophenyl)amide /F 2-(2,3,4-trimethoxyphenyl)- 1H-benz 043_ NH 168 imidazole-4-(N-2-hydroxyl-4-pyrimi -- / OCH3 89 dinyl)amide HO N 84 192-(2,3 ,4-trimethoxyphenyl)- 1 H-benz - C38 19imidazole-4-(N-6-purinyl)amide /0GN N8 3 OH 2-(2,3 ,4-trimethoxyphenyl)- 1H-benz 170 imidazole-4-(N-6-hydroxyl-2-puriny OCH / 0N N 89 1)amide -N N N H H (L)-2-(3-hydroxyl-4-methoxyphenyl OH 02N H HO 11)-l1H-benzimidazole-4- [N-(l1-hydrox - CH H OH ymethyl-2-p-nitrophenylhydroxyeth \ /0G yl)] amideHO HH (L)-2-(3-hydroxyl-4-methoxyphenyl OH H2N H HO 12)-1H-benzimidazole-4-[N-(1-hydrox C3H 9 1ymethyl-2-p-aminophenylhydroxyet ' /NH hyl)] amide HO / H OH cI 2-(3-hydroxyl-4-methoxyphenyl)- 1 -)H 173 H-benzimidazole-4-[N-(1-methyl-2- OCH / 0bH CH3 90 p-chlorophenylhydroxyethyl)] amide HO OH H 2-(3-hydroxyl-4-methoxyphenyl)- 1 - N 9 174 H-benzimidazole-4-(N-N'-piperidin OC/ 091 yl)amide OH HN, H 2-(3-hydroxyl-4-methoxyphenyl)- 1 -CN 175 H-benzimidazole-4-(N-2-piperazinyl -- / 0Gb93 )amideN H OH N 2-(3-hydroxyl-4-methoxyphenyl)- 1 -H 176 H-benzimidazole-4-(N-2'-benzimida O / 0G 93 zolyl)amide
N
85 OH H 2-(3-hydroxyl-4-methoxyphenyl)- 1 OH 177 H-benzimidazole-4-(N-o-aminophen OCH3 94 yl)amide NH2 OH H 2-(3-hydroxyl-4-methoxyphenyl)- 1 N 178 H-benzimidazole-4-(N-5-benzimida OCH3 90 zolonyl)amide N H 2-(3-hydroxyl-4-methoxyphenyl)- 1 OH N 179 H-benzimidazole-4-(N-4'-carbonami - H2N N 86 do-5'-imidazolyl)amide H 0 OH H 2-(3-hydroxyl-4-methoxyphenyl)-1 O 180 H-benzimidazole-4-(N-4'-pyrazolyl) ocH3 92 amide NH OH 2-(3-hydroxyl-4-methoxyphenyl)- 1 181 H-benzimidazole-4-(N-(N'-piperazi / ocH3 N-N NH 91 nyl))amide OH N 2-(3-hydroxyl-4-methoxyphenyl)- 1 182 H-benzimidazole-4-(N-2-pyrazinyl) -- / OcH 3 91 amide N N OH 2-(3-hydroxyl-4-methoxyphenyl)- 1 183 H-benzimidazole-4-(N-2-pyrimidiny \ & ocH3 93 1)amide N OH 2-(3-hydroxyl-4-methoxyphenyl)-1 N 184 H-benzimidazole-4-(N-2-pyridyl) oc/0& H 92 amide N' H OH CH3 2-(3-hydroxyl-4-methoxyphenyl)- 1 N 185 H-benzimidazole-4-(N-4-methyl-5-t \ /ocH3 93 hiazolyl)amide
(KN
86 OHN 2-(3-hydroxyl-4-methoxyphenyl)- 1 O HO 186 H-benzimidazole-4-(N-2,4-dihydrox OmH 3 H \ / 89 yl-5-pyrimidinyl)amide OH OH OCH 3 2-(3-hydroxyl-4-methoxyphenyl)- 1 N H 187 H-benzimidazole-4-(N-4,6-dimethox -- / OH3 N 92 y-2-pyrimidinyl)amide N
OCH
3 OH cI 2-(3-hydroxyl-4-methoxyphenyl)- 1 N 188 H-benzimidazole-4-(N-4-chloro-6-a OmH3 N 92 mino-2-pyrimidinyl)amide
NH
2 OH c' 2-(3-hydroxyl-4-methoxyphenyl)- 1 N 189 H-benzimidazole-4-(N-4,6-dichloro- /oH3 / 93 5-pyrimidinyl)amide N CI OH H 2-(3-hydroxyl-4-methoxyphenyl)-1 N 190 H-benzimidazole-4-(N-o-fluorophen - /OH3 94 yl)amide F OH N 2-(3-hydroxyl-4-methoxyphenyl)- 1 NH 191 H-benzimidazole-4-(N-2-hydroxyl-4 oms N -pyrimidinyl)amide HO90 HO N 2-(3-hydroxyl-4-methoxyphenyl)-1 OH H 192 H-benzimidazole-4-(N-6-purinyl) / OH3 N N 94 amide N OH OH 2-(3-hydroxyl-4-methoxyphenyl)- 1 193 H-benzimidazole-4-(N-6-hydroxyl-2 - / OmsH3 N 89 -purinyl)amide N N H H 0 2 N (L)-2-(2-pyridyl)- 1H-benzimidazole O.N.H H OH 194 -4-[N-(1-hydroxymethyl-2-p-nitroph H enylhydroxyethyl)]amide H NH H 87
H
2 N (L)-2-(2-pyridyl)- 1 H-benzimidazole NHH OH 195 -4-[N-(1-hydroxymethyl-2-p-aminop H 90 henylhydroxyethyl)]amide HO NH H CI 2-(2-pyridyl)- 1H-benzimidazole-4-[ H 196 N-(1-methyl-2-p-chlorophenylhydro CHs xyethyl)]amide HO NH H 197 2-(2-pyridyl)-1H-benzimidazole-4-( N N 90 N-N'-piperidinyl)amide \ H 2-(2-pyridyl)- 1H-benzimidazole-4-( N 198 N-2-piperazinyl)amide 91 H 199 2-(2-pyridyl)- 1H-benzimidazole-4-( N_ N N-2'-benzimidazolyl)amide \ / 200 2-(2-pyridyl)- 1H-benzimidazole-4-( N89 N-o-aminophenyl)amide \ /
NH
2 2-(2-pyridyl)- 1H-benzimidazole-4-( N 88 N-5-benzimidazolonyl)amide 2-(2-pyridyl)- 1H-benzimidazole-4-( N. 202 N-4' -carbonamido-5 '-imidazolyl) /H2N N/ 86 amide H N 232-(2-pyridyl)- 1H-benzimidazole-4-( 87-1 22N-4'-pyrbnmd'idazolyl)amide 8 amide /H 0 H 203 2-(2-pyridyl)- 1H-benzimidazole-4-( N_ N--N N N-4'-pyrazolyl)amide \8 N H 2-(2-pyridyl)- 1H-benzimidazole-4-( N__ HH 9 204 N-(N'-piperazinyl))amide \- \/ H 9 205 2-(2-pyridyl)- 1H-benzimidazole-4-( N_ N90 N-2-pyrazinyl)amide \/
H
88 2-(2-pyridyl)- 1H-benzimidazole-4-( N N 206 N-2-pyrimidinyl)amide \ / N91 2-(2-pyridyl)- 1H-benzimidazole-4-( N_ N "N 207 N-2-pyridyl)amide \9 CH 208 2-(2-pyridyl)- 1H-benzimidazole-4-( - 93 N-4-methyl-5-thiazolyl)amide \9 2-(2-pyridyl)- 1H-benzimidazole-4-( N H 209 N-2,4-dihydroxyl-5-pyrimidinyl) HO 88 amide H
OCH
3 2-(2-pyridyl)- 1H-benzimidazole-4-( N_ H 210 N-4,6-dimethoxy-2-pyrimidinyl) N \ 90 amideNx
OCH
3 CI 2-(2-pyridyl)- 1H-benzimidazole-4-( N_ H 211 N-4-chloro-6-amino-2-pyrimidinyl) \ / 93 amideN
NH
2 CI 212 2-(2-pyridyl)- 1H-benzimidazole-4-( N H N-4,6-dichloro-5-pyrimidinyl)amide \ / \N CI H 2-(2-pyridyl)- 1H-benzimidazole-4-( N 213 N-o-fluorophenyl)amide / NH 214 2-(2-pyridyl)- 1H-benzimidazole-4-( N N-2-hydroxyl-4-pyrimidinyl)amide / N HO 215 2-(2-pyridyl)- 1H-benzimidazole-4-( NN N-6-purinyl)amide 89 OH 216 N-6-hydroxyl-2-purinyl)amide 88 O2N (L)-2-(3-pyridyl)- 1H-benzimidazole NH OH 217 -4-[N-(1-hydroxymethyl-2-p-nitroph H 93 enylhydroxyethyl)]amide HO NH H
H
2 N (L)-2-(3-pyridyl)-1H-benzimidazole N H OH 218 -4-[N-(1-hydroxymethyl-2-p-aminop H 94 henylhydroxyethyl)]amide HO NH H H 219 2-(3-pyridyl)- 1H-benzimidazole-4-( HN N-2-piperazinyl)amide N H 220 2-(3-pyridyl)- 1H-benzimidazole-4-( N N-2-pyrimidinyl)amide N 0 2 N (L)-2-(4-pyridyl)- 1H-benzimidazole Na H OH 221 -4-[N-(1-hydroxymethyl-2-p-nitroph H 93 enylhydroxyethyl)]amide HO NH H
H
2 N (L)-2-(4-pyridyl)-1H-benzimidazole N H H OH 222 -4-[N-(1-hydroxymethyl-2-p-aminop H 94 henylhydroxyethyl)]amide H NH H H HN N 223 2-(4-pyridyl)- 1H-benzimidazole-4-( N N-2-piperazinyl)amide H 224 2-(4-pyridyl)- 1H-benzimidazole-4-( N N 9 N-2-pyrimidinyl)amide N H 0 2 NH (L)-2-(3-pyridazinyl)- 1H-benzimida NH OH 225 zole-4-[N- (1 -hydroxymethyl-2-p-nit H 92 rophenylhydroxyethyl)]amide HO NH H 90
H
2 N (L)-2-(3-pyridazinyl)- 1H-benzimida H OH 226 zole-4-[N-(1-hydroxymethyl-2-p-am H 91 inophenylhydroxyethyl)]amide HO NH H CI H 2-(3-pyridazinyl)- 1H-benzimidazole NN N HH 227 -4-[N-(1-methyl-2-p-chlorophenylhy CH3 94 NN droxyethyl)]amide H N 228 2-(3-pyridazinyl)-1H-benzimidazole NN / N -4-(N-N'-piperdinyl)amide 229 2-(3-pyridazinyl)-1H-benzimidazole N HN -4-(N-2-piperazinyl)amide N H NN 230 2-(3-pyridazinyl)-1H-benzimidazole N -4-(N-2'-benzimidazolyl)amide N H NH 231 2-(3-pyridazinyl)-1H-benzimidazole Na 93 -4-(N-o-aminophenyl)amide NH2 NN 232 2-(3-pyridazinyl)-1H-benzimidazole N" N > 93 -4-(N-5-benzimidazolonyl)amide H H 2-(3-pyridazinyl)-1H-benzimidazole N N 233 -4-(N-4'-carbonamido-5'-imidazolyl H2N N 86 )amide H H N 234 2-(3-pyridazinyl)-1H-benzimidazole N 89 -4-(N-4'-pyrazolyl)amide \ NH 2-(3-pyridazinyl)-1H-benzimidazole N 235 -4-(N-(N'-piperazinyl))amide / - \-N NH 87 91 NN 2-(3-pyridazinyl)-1H-benzimidazole NNN -4-(N-2-pyrazinyl)amide N N H N 237 2-(3-pyridazinyl)-1H-benzimidazole N0 -4-(N-2-pyrimidinyl)amide H N 238 2-(3-pyridazinyl)-1H-benzimidazole N1 -4-(N-2-pyridyl)amide 91 H _N H 239 2-(3-pyridazinyl)-1H-benzimidazole N -4-(N-4-methyl-5-thiazolyl)amide 2-(3-pyridazinyl)-1H-benzimidazole N OH 240 -4-(N-2,4-dihydroxyl-5-pyrimidinyl) N 89 amide H 2-(3-pyridazinyl)-1H-benzimidazole N' N 241 -4-(N-4,6-dimethoxy-2-pyrimidinyl) N 94 amide N CI 2-(3-pyridazinyl)-1H-benzimidazole NN H 242 -4-(N-4-chloro-6-amino-2-pyrimidin N \/90 yl)amide NZ
NH
2 CI 2-(3-pyridazinyl)-1H-benzimidazole NN N 243 -4-(N-4,6-dichloro-5-pyrimidinyl) N 93 amide N CI 244 2-(3-pyridazinyl)-1H-benzimidazole N 92 -4-(N-o-fluorophenyl)amide NF 2-(3-pyridazinyl)-1H-benzimidazole NN NH 245 -4-(N-2-hydroxyl-4-pyrimidinyl) N 88 amide HO N 92 N NH 246 2-(3-pyridazinyl)- 1H-benzimidazole N -4-(N-6-purinyl)amide NN N OH N 247 2-(3-pyridazinyl)- 1H-benzimidazole N N N -4-(N-6-hydroxyl-2-purinyl)amide N N -N N N H H (L)-2-(4-pyridazinyl)- 1H-benzimida N 0 2 NH H OH 248 zole-4-[N- (1 -hydroxymethyl-2-p-nit H 92 rophenylhydroxyethyl)]amide HO NH H
H
2 N (L)-2-(4-pyridazinyl)- 1H-benzimida H H OH 249 zole-4-[N-(1-hydroxymethyl-2-p-am H 90 inophenylhydroxyethyl)]amide H NH H H N HN N 250 2-(4-pyridazinyl)-1H-benzimidazole N -4-(N-2-piperazinyl)amide H 251 2-(4-pyridazinyl)-1H-benzimidazole N2 -4-(N-2-pyrimidinyl)amide N N H 0 2 N (L)-2-(2-pyrazinyl)- 1H-benzimidazo H OH 252 le-4- [N-(1 -hydroxymethyl-2-p-nitro H 92 phenylhydroxyethyl)]amide N HO NH H H2N (L)-2-(2-pyrazinyl)- 1H-benzimidazo N H H H 253 le-4-[N-(1-hydroxymethyl-2-p-amin H 89 ophenylhydroxyethyl)]amide N HO N H CI N H 2-(2-pyrazinyl)-1H-benzimidazole-4 N 254 -[N-(1-methyl-2-p-chlorophenylhydr CH3 94 oxyethyl)]amide N HO H 93 N H 255 2-(2-pyrazinyl)-1H-benzimidazole-4 N 90 -(N-N'-piperidinyl)amide N H H 256 2-(2-pyrazinyl)-1H-benzimidazole-4 NH -(N-2-piperazinyl)amide N N H 257 2-(2-pyrazinyl)-1H-benzimidazole-4 N92 -(N-2'-benzimidazolyl)amide N N H NN 258 2-(2-pyrazinyl)-1H-benzimidazole-4 90 -(N-o-aminophenyl)amide NH9 N NH2 N 259 2-(2-pyrazinyl)-1H-benzimidazole-4 -(N-5-benzimidazolonyl)amide N N HH 2-(2-pyrazinyl)-1H-benzimidazole-4 N N 260 -(N-4'-carbonamido-5'-imidazolyl) H2N N 87 H amide N 0H NN 261 2-(2-pyrazinyl)-1H-benzimidazole-4 I/ 90 -(N-4'-pyrazolyl)amide \ N NH 262 2-(2-pyrazinyl)-1H-benzimidazole-4 NNN NH 91 -(N-(N'-piperazinyl))amide N NN 263 2-(2-pyrazinyl)-1H-benzimidazole-4 1 93 -(N-2-pyrazinyl)amide N 264 2-(2-pyrazinyl)-1H-benzimidazole-4 N -(N-2-pyrimidinyl)amide N N H NN 265 2-(2-pyrazinyl)-1H-benzimidazole-4 88 -(N-2-pyridyl)amide N N H 94 N CH 3 266 2-(2-pyrazinyl)- 1H-benzimidazole-4 89 -(N-4-methyl-5-thiazolyl)amide N NS H 2-(2-pyrazinyl)- 1H-benzimidazole-4 N HOH 267 -(N-2,4-dihydroxyl-5-pyrimidinyl)a H \ 87 mide N OH
OCH
3 2-(2-pyrazinyl)-1H-benzimidazole-4 H N 268 -(N-4,6-dimethoxy-2-pyrimidinyl)a N-<\/92 mide N OCH 3 CI 2-(2-pyrazinyl)-1H-benzimidazole-4 NN H 269 -(N-4-chloro-6-amino-2-pyrimidinyl N \ 90 )amide NN NH2 CI 2-(2-pyrazinyl)-1H-benzimidazole-4 N N 270 -(N-4,6-dichloro-5-pyrimidinyl)ami NN 91 N 271 2-(2-pyrazinyl)-1H-benzimidazole-4 93 -(N-o-fluorophenyl)amide 272 2-(2-pyrazinyl)-1H-benzimidazole-4 N H89 -(N-2-hydroxyl-4-pyrimidinyl)amide N N HO N 273 2-(2-pyrazinyl)-1H-benzimidazole-4 N 94 -(N-6-purpyl)amideN NN N~ H 272 2-(2-pyrazinyl)-1H-benzimidazole-4 N N -(N-6-hydroxyl-2-purinyl)amide N 89 HO N 95 0 2 N (L)-2-(2-piperazinyl)- 1H-benzimida H OH 275 zole-4-[N-(1-hydroxymethyl-2-p-nit HN H 93 rophenylhydroxyethyl)]amide NH HO NH IO H
H
2 N H (L)-2-(2-piperazinyl)- 1H-benzimida H 276 zole-4-[N-(1-hydroxymethyl-2-p-am HN NH 90 inophenylhydroxyethyl)]amide NH HO H CI 2-(2-piperazinyl)- 1 H-benzimidazole H H H 277 -4-[N-(1-methyl-2-p-chlorophenylhy HN CH3 91 droxyethyl)]amide NH H NH H 278 2-(2-piperazinyl)- 1 H-benzimidazole HN N91 -4-(N-N'-piperidinyl)amide NH H 279 2-(2-piperazinyl)- 1 H-benzimidazole HN HN93 -4-(N-2-piperazinyl)amide NH N H 280 2-(2-piperazinyl)- 1 H-benzimidazole HN 92 -4-(N-2'-benzimidazolyl)amide HN NH H 281 2-(2-piperazinyl)- 1 H-benzimidazole HN 93 -4-(N-o-aminophenyl)amide NHH NH 282 2-(2-piperazinyl)- 1 H-benzimidazole HN O 94 -4-(N-5-benzimidazolonyl)amide NH > NH NH 96 H 2-(2-piperazinyl)- 1 H-benzimidazole N 283 -4-(N-4'-carbonamido-5'-imidazolyl HN H2N 89 H )amide NH H N 284 2-(2-piperazinyl)- 1 H-benzimidazole HN 92 -4-(N-4'-pyrazolyl)amide NH NH NHH 285 2-(2-piperazinyl)- 1 H-benzimidazole HN N-N NH 92 -4-(N-(N'-piperazinyl))amide NH NH 286 2-(2-piperazinyl)- 1 H-benzimidazole HN N 92 -4-(N-2-pyrazinyl)amide NH N N NH H 287 2-(2-piperazinyl)- 1 H-benzimidazole HN N93 -4-(N-2-pyrimidinyl)amide N N NH H 288 2-(2-piperazinyl)- 1 H-benzimidazole HN 92 -4-(N-2-pyridyl)amide NH N NH N
CH
3 289 2-(2-piperazinyl)- 1 H-benzimidazole HN 91 -4-(N-4-methyl-5-thiazolyl)amide NH NH. 2-(2-piperazinyl)- 1 H-benzimidazole HO HO 290 -4-(N-2,4-dihydroxyl-5-pyrimidinyl) HN ) 87 amide NH N H
OCH
3 2-(2-piperazinyl)- 1 H-benzimidazole N_ 291 -4-(N-4,6-dimethoxy-2-pyrimidinyl) HN / 90 amide NH N
OCH
3 97 cl 2-(2-piperazinyl)- 1 H-benzimidazole N H 292 -4-(N-4-chloro-6-amino-2-pyrimidin HN NH N 88 yl)amide NH N
NH
2 CI 2-(2-piperazinyl)- 1 H-benzimidazole N 293 -4-(N-4,6-dichloro-5-pyrimidinyl)a HN 93 mide NH N CI H 294 2-(2-piperazinyl)- 1 H-benzimidazole HN 9 -4-(N-o-fluorophenyl)amide NH 2-(2-piperazinyl)- 1 H-benzimidazole NH 295 -4-(N-2-hydroxyl-4-pyrimidinyl)ami HN 89 deHO N NH 296 2-(2-piperazinyl)- 1 H-benzimidazole HN N90 -4-(N-6-purinyl)amide NH N OH 297 2-(2-piperazinyl)- 1 H-benzimidazole HN N 87 -4-(N-6-hydroxyl-2-purinyl)amide H NH-N N N H H 0 2 N (L)-2-(N,N'-diethyl-2-piperazinyl)- 1 N OH 298 H-benzimidazole-4-[N-(1-hydroxym N C H 90 ethyl-2-p-nitrophenylhydroxyethyl)] HO NH H amide
H
2 N (L)-2-(N,N'-diethyl-2-piperazinyl)- 1 H 3 C N NH OH 299 H-benzimidazole-4-[N-(1-hydroxym N C H 91 ethyl-2-p-aminophenylhydroxyethyl HO H )]amide H 2-(N,N'-diethyl-2-piperazinyl)- 1H-b H3C N HN N 300 enzimidazole-4-(N-2-piperazinyl)am N C90 ide N 98 2-(N,N'-diethyl-2-piperazinyl)- 1H-b HC l"N N 301 enzimidazole-4-(N-2-pyrimidinyl)a N C91 mide N 'lN) 0 2 N N ~H O 302 (L)-2-(N-piperazinyl)-1H-benzimida N H H H 92 zole-4-[N- (1 -hydroxymethyl-2-p-nit NH NH rophenylhydroxyethyl)]amide HO H
H
2 N 303 (L)-2-(N-piperazinyl)-1H-benzimida N H OH H zole-4-[N-(1-hydroxymethyl-2-p-am NH NH inophenylhydroxyethyl)]amide HO H CI 2-(N-piperazinyl)- 1H-benzimidazole N H 304 -4-[N-(1-methyl-2-p-chlorophenylhy NH CH droxyethyl)]amide HO NH H 305 2-(N-piperazinyl)- 1H-benzimidazole N N N9 -4-(N-N'-piperidinyl)amide N NHH 2-(N-piperazinyl)- 1H-benzimidazole N HN N 306 0 91 -4-(N-2-piperazinyl)amide NH H 307 2-(N-piperazinyl)- 1H-benzimidazole N N 92 -4-(N-2'-benzimidazolyl)amide NH N H 308 2-(N-piperazinyl)- 1H-benzimidazole N -4-(N-o-aminophenyl)amide NH NH2 99 309 2-(N-piperazinyl)- 1H-benzimidazole N -4-(N-5-benzimidazolonyl)amide NH N N H H H 2-(N-piperazinyl)- 1H-benzimidazole N N 310 -4-(N-4'-carbonamido-5'-imidazolyl N H2N 90 amidee H 0 H 311 2-(N-piperazinyl)- 1H-benzimidazole N N 93 -4-(N-4'-pyrazolyl)amide NH 2-(N-piperazinyl)- 1H-benzimidazole N H 100 9 312 -4-(N-(N'-piperazinyl))amide N H -N \- NH 9 N 313 2-(N-piperazinyl)- 1H-benzimidazole N 92 -4-(N-2-pyrazinyl)amide NH N N H 2-(N-piperazinyl)- 1H-benzimidazole N N 314 -4-(N-2-pyrimidinyl)amide NH N N H 315 2-(N-piperazinyl)- 1H-benzimidazole N N -4-(N-2-pyridyl)amide NH N H 316 2-(N-piperazinyl)- 1H-benzimidazole N CH9 -4-(N-4-methyl-5-thiazolyl)amide NH N S H 2-(N-piperazinyl)- 1H-benzimidazole N H N 317 -4-(N-2,4-dihydroxyl-5-pyrimidinyl) NH N 88 amide
H
100
OCH
3 2-(N-piperazinyl)- 1H-benzimidazole N H 318 -4-(N-4,6-dimethoxy-2-pyrimidinyl) NHN \ 90 amide HN X
OCH
3 CI 2-(N-piperazinyl)- 1H-benzimidazole N N H 319 -4-(N-4-chloro-6-amino-2-pyrimidin NHN \ 91 yl)amide N
NH
2 CI 2-(N-piperazinyl)- 1H-benzimidazole N N 320 -4-(N-4,6-dichloro-5-pyrimidinyl)a NH93 mide N CI 32 2-(N-piperazinyl)- 1H-benzimidazole N N K -4-(N-o-fluorophenyl)amide NH F 2-(N-piperazinyl)- 1H-benzimidazole N 322 -4-(N-2-hydroxyl-4-pyrimidinyl)ami NH N 88 HO N HO 323 2-(N-piperazinyl)- 1H-benzimidazole N N N89 -4-(N-6-purinyl)amide N OH 324 2-(N-piperazinyl)-1H-benzimidazole N N N 8 -4-(N-6-hydroxyl-2-purinyl)amide NH -N N N H H 0 2 N (L)-2-(N-ethyl-N'-piperazinyl)-1H-b NN H OH 325 enzimidazole-4-[N-(1-hydroxymeth H 92 yl-2-p-nitrophenylhydroxyethyl)]am N CH, HO NH H ide
H
2 N (L)-2-(N-ethyl-N'-piperazinyl)-1H-b K H 326 enzimidazole-4-[N-(1-hydroxymeth H 93 yl-2-p-aminophenylhydroxyethyl)]a HO NH mide 101 H 327 2-(N-ethyl-N'-piperazinyl)- 1H-benzi N HN N midazole-4-(N-2-piperazinyl)amide N CH, H 328 2-(N-ethyl-N'-piperazinyl)- 1H-benzi N N 93 midazole-4-(N-2-pyrimidinyl)amide N CH, N N H 0 2 N H N H OH 329 (L)-2-(2-pyrrolyl)- 1H-benzimidazol H 92 e-4-[N-(1-hydroxymethyl-2-p-nitrop HO NH henylhydroxyethyl)]amide H H
H
2 N (L)-2-(2-pyrrolyl)-1H-benzimidazol N H OH 330 e-4-[N-(l-hydroxymethyl-2-p-amino HO NH H 91 phenylhydroxyethyl)]amide CI 2-(2-pyrrolyl)- 1H-benzimidazole-4-[ HN H 331 N-(1-methyl-2-p-chlorophenylhydro CH3 92 xyethyl)]amide H NH H N 332 2-(2-pyrrolyl)- 1H-benzimidazole-4-( N N -N 93 N-N'-piperidinyl)amide H 333 2-(2-pyrrolyl)- 1H-benzimidazole-4-( NH90 N-2-piperazinyl)amide 9/ H H N 334 2-(2-pyrrolyl)- 1H-benzimidazole-4-( N N-2'-benzimidazolyl)amide )- H HH 2-(2-pyrrolyl)- 1H-benzimidazole-4-( N90 N-o-aminophenyl)amide /NH2 102 H H N 36 2-(2-pyrrolyl)- 1H-benzimidazole-4-( N =o 9 37 N-4'-cbnmido-5 ' -imidzlla HN H>8 N~I ide /H 0 H N -N H 382-(2-pyrrolyl)- 1H-benzimidazole-4-( N /9 38 N-4'-pyrazolyl)amide \9/ NH HH ' 2-(2-pyrrolyl)- 1 H-benzimidazole-4-( N ___/_N 9 339 N-(N'-piperazinyl))amide\ /N__NH 9 N H 2-(2-pyrrolyl)- 1H-benzimidazole-4-( N 340 N-2-pyrazinyl)amide ) 95III H H 2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N 341 N-2-pyrimidinyl)amide N N-9 H HH 2-(2-pyrrolyl)- 1H-benzimidazole-4-( N 342 N-2-pyridyl)amide N /94 H H H 2-(2-pyrrolyl)- 1 H-benzimidazole-4-( N 9 33 N-4-methyl-5-thiazolyl)amide\ / 2-(2-pyrrolyl)- 1 H-benzimidazole-4-( H N 344 N-2,4-dihydroxyl-5-pyrimidinyl)ami N HO - / 87 de
/O
103 OCH3 2-(2-pyrrolyl)- 1 H-benzimidazole-4-( N . T r 1 ,- 1 1 H 9 345 1N-4,6-aimetnoxy-2-pyrimiainyl)am1 \ N /9 de OCH3 cI 2-(2-pyrrolyl)- i H-benzimidazole-4-( HNN N" ,o H 9 346 N-4-chloro-6-amino-2-pyrimidinyl)a \ N /9 mide NHN NH HH 2-(2-pyrrolyl)- 1 H-benzimidazole-4-( N N. 347 N-4,6-dichloro-5-pyrimidinyl)amide \N /93K. HH 2-(2-pyrrolyl)- 1H-benzimidazole-4-( N N9 348 N-o-fluorophenyl)amide\ / H N 2-(2-pyrrolyl)- 1H-benzimidazole-4-( N 86 39N-2-hydroxyl-4-pyrimidinyl)amide\ / HH N N N 302-(2-pyrrolyl)- 1H-benzimidazole-4-( NN9 OH HO N 31 2-(2-pyrrolyl)- 1 H-benzimidazole-4-( /-oNN87 31N-6-hydroxyl-2-purinyl)amide 8 -N J N N H H (L)-2-(4-methyl-5 -aminothiazolyl)- 1 N CH 3 02N H 32H-benzimidazole-4-[N-(l1-hydroxym H 93 ethyl-2-p-nitrophenylhydroxyethyl)] H NH amide HO / H (L)-2-(4-methyl-5 -aminothiazolyl)- 1 N CH 3 H2N H 353 H-benzimidazole-4-[N-(l1-hydroxym 2KH 91 ethyl-2-p-aminophenylhydroxyethyl
NH
2 NH )] amide HO / H 104 CH3 ci 2-(4-methyl-5-aminothiazolyl)- 1H-b N H H 354 enzimidazole-4-[N-(1-methyl-2-p-ch g NC) CH3 93 lorophenylhydroxyethyl)]amide H NHH
CH
3 H 2-(4-methyl-5-aminothiazolyl)- 1H-b N N N 355 enzimidazole-4-(N-N'-piperidinyl)a A $1. NH 2 94 mide CH3 H 2-(4-methyl-5-aminothiazolyl)- 1H-b N HH HN N 356 enzimidazole-4-(N-2-piperazinyl)am A NH2 90 ide 2 N H
CH
3 2-(4-methyl-5-aminothiazolyl)- 1H-b N 357 enzimidazole-4-(N-2'-benzimidazol A NH 2 N 94 yl)amide N
CH
3 2-(4-methyl-5-aminothiazolyl)- 1H-b N 358 enzimidazole-4-(N-o-aminophenyl)a A NH2 93 mide NNH2
CH
3 2-(4-methyl-5-aminothiazolyl)- 1H-b N 359 enzimidazole-4-(N-5-benzimidazolo NH 2 94 nyl)amide H H
CH
3 H 2-(4-methyl-5-aminothiazolyl)- 1H-b N H2N 9 360 enzimidazole-4-(N-4'-carbonamido- NH 2 90 5'-imidazolyl)amide H 0
CH
3 H 2-(4-methyl-5-aminothiazolyl)- 1H-b N NN 361 enzimidazole-4-(N-4'-pyrazolyl)ami AJKgK NH 2 94 de NH
CH
3 2-(4-methyl-5-aminothiazolyl)- 1H-b N 362 enzimidazole-4-(N-(N'-piperazinyl)) H NH2 N-N NH 92 amide 105
CH
3 N 2-(4-methyl-5-aminothiazolyl)- 1H-b N N 363 enzimidazole-4-(N-2-pyrazinyl)amid g N 94 eS NH H
CH
3 2-(4-methyl-5-aminothiazolyl)- 1H-b N N 364 enzimidazole-4-(N-2-pyrimidinyl)a A NH 2 94 mide N N H
CH
3 365 2-(4-methyl-5-aminothiazolyl)- 1H-b N 93 enzimidazole-4-(N-2-pyridyl)amide A S NH 2 N H 2-(4-methyl-5-aminothiazolyl)- 1H-b NN CH3 366 enzimidazole-4-(N-4-methyl-5-thiaz g 90 olyl)amide SS HH
CH
3 N 2-(4-methyl-5-aminothiazolyl)- 1H-b NH 367 enzimidazole-4-(N-2,4-dihydroxyl-5 A NH2 HO N 91 -pyrimidinyl)amide OH
CH
3
OCH
3 2-(4-methyl-5-aminothiazolyl)- 1H-b N N_ 368 enzimidazole-4-(1-4,6-dimethoxy-2 NH2 N 93
OCH
3
CH
3 ci 2-(4-methyl-5-aminothiazolyl)- 1H-b N N_ 369 enzimidazole-4-(Nchloro-6-amin A NH2 N 93
NH
2
CH
3 ci 2-(4-methyl-5-aminothiazolyl)- 1H-b N N 370 enzimidazole-4-(N-4,6-dichloro-5-p A g1 NHN 88 yrimidinyl)amide N CI CH3H 2-(4-methyl-5-aminothiazolyl)- 1H-b N CH 3 371 enzimidazole-4-(N-o-fluorophenyl)a A NH2 89 mide
F
106 2-(4-methyl-5 -aminothiazolyl)- 1 H-b N- NH 372 enzimidazole-4-(N-2-hydroxyl-4-pyr - 8 imidinyl)amide A S NH 2 N- ~8 N- CH 3 J 373 2-(4-methyl-5-aminothiazolyl)- 1H-b II N~ NH9 enzimidazole-4-(N-6-purinyl)amide A S~ NH 2 NN9 N N H
CH
3 OH 2-(4-methyl-5-aminothiazolyl)- 1H-b
N
374 enzimidazole-4-(N-6-hydroxyl-2-pur , NH 2 N 90 inyl)amide A H 1 ) _N J N N H H (L)-2-(2-quinolinyl)- 1H-benzimidaz N2 375 ole-4- [N-(l1-hydroxymethyl-2-p-nitr H 91 ophenylhydroxyethyl)]amide HO NHH
H
2 NH (L)-2-(2-quinolinyl)- ivi-benzlmluazN H OHH 376 ole-4- [N-(l1-hydroxymethyl-2-p-amai 93 nophenylhydroxyethyl)]amide HO / H cI H 377 4-IIN-(l1-methyl-2-p-chlorophenyllhy C3 9 droxyethyl)]amide HO HNH CH9 H N-2qioiy)lHbniia e No 38 4-(N-N' -piperidinyl)amide x 2-(2-quinolinyl)-1H-benzimidazole-1 4-(N-2-piperazinyl)amide 9
H
107 2-(2-quinolinyl)-1H-benzimidazole- 93 380 4-(N-2'-benzimidazolyl)amide 93 H H NN 2-(2-quinolinyl)-1H-benzimidazole 381 4-(N-o-aminophenyl)amide >NH2 92 H 382 2-(2-quinolinyl)-1H-benzimidazole- N91 4-(N-5-benzimidazolonyl)amide N H H 2-(2-quinolinyl)-1H-benzimidazole- N N 383 4-(N-4'-carbonamido-5'-imidazolyl) H2N X 91 N amideH 0 H N4rN 2-(2-quinolinyl)-1H-benzimidazole- N N 9 384 4-(N-4'-pyrazolyl)amide N9N NH 2-(2-quinolinyl)-1H-benzimidazole- N H 385 N-\ / NH 92 4-(N-(N'-piperazinyl))amide N N N 388 2-(2-quinolinyl)-1H-benzimidazole- N9 N 4-(N-2-pyrazinyl)amide H N 387 2-(2-quinolinyl)-1H-benzimidazole- N4 4-(N-2-pyrimidinyl)amide N N" H N 382-(2-quinolinyl)-1H-benzimidazole- N92 384-(N-2-pyridyl)amide 92
H
108
CH
3 N 389 2-(2-quinolinyl)- 1H-benzimidazole- N 4-(N-4-methyl-5-thiazolyl)amide -N N OH3 2-(2-quinolinyl)-1H-benzimidazole- NN 390 4-(N-2,4-dihYdroxyl-5-pyrimidinyl) 87 amide N OH
OCH
3 2-(2-quinolinyl)- 1H-benzimidazole- N N N 'N H 391 4-(N-4,6-dimethoxy-2-pyrimidinyl)a N 94 mide e N
OCH
3 c 2-(2-quinolinyl)-1H-benzimidazole- N N 392 4-(N-4-chloro-6-amino-2-pyrimidin N 93 yl)amide
NH
2 CI 2-(2-quinolinyl)-1H-benzimidazole- N 393 4-(N-4,6-dichloro-5-pyrimidinyl)am 93 ide N N cI H 396 2-(2-quinolinyl)-1H-benzimidazole- 90 4-(N-o-fluorophenyl)amide F 2-(2-quinolinyl)-in- uenzlmluazoie- N 395 4-(N-2-hydroxyl-4-pyrimidinyl)amii 88 deAx HO N H 2-(2-quinolinyl)-1H-benzimidazole- N 8 396 4-(N-6-purinyl)amide N N 90 N H OH N 397 2-(2-quinolinyl)-1H-benzimidazole- N N 8 4-(N-6-hydroxyl-2-purinyl)amide A -N N N H H 109 0 2 N (L)-2-(3-quinolinyl)- 1H-benzimidaz N H OH 398 ole-4-[N-(1-hydroxymethyl-2-p-nitr H 93 ophenylhydroxyethyl)]amide HO NH H
H
2 N (L)-2-(3-quinolinyl)-1H-benzimidaz NN H 9 399 ole-4-[N-(1-hydroxymethyl-2-p-ami H nophenylhydroxyethyl)]amide HO [H H H 400 2-(3-quinolinyl)- 1H-benzimidazole- N HN N 4-(N-2-piperazinyl)amide H 401 2-(3-quinolinyl)-1H-benzimidazole- N N 4-(N-2-pyrimidinyl)amide N H 0 2 N (L)-2-(2-piperidinyl)-1H-benzimidaz 0 a H OH 402 ole-4-[N-(1-hydroxymethyl-2-p-nitr H 91 ophenylhydroxyethyl)]amide HO /NH H
H
2 N (L)-2-(2-piperidinyl)-1H-benzimidaz H OH 403 ole-4-[N-(1-hydroxymethyl-2-p-ami H 89 nophenylhydroxyethyl)]amide H NH H CI 2-(2-piperidinyl)- 1H-benzimidazole- H 404 4-[N-(1-methyl-2-p-chlorophenylhy CH3 91 droxyethyl)]amide HO NH H 2-(2-piperidinyl)- 1H-benzimidazole- N N 92 405 4-(N-N'- piperidinyl)amide H 406 2-(2-piperidinyl)- 1H-benzimidazole- HN 90 4-(N-2-piperazinyl)amide N
H
110 H N 407 2-(2-piperidinyl)- 1H-benzimidazole- 93 4-(N-2'-benzimidazolyl)amide H H H N 2-(2-piperidinyl)- 1H-benzimidazole- N O 93 408 4-(N-o-aminophenyl)amide NH H H 2-(2-piperidinyl)- 1H-benzimidazole- N' N9 410 4-(N-5-benzimidazolonyl)amide N N HHH HH N 422-(2-piperidinyl)- 1H-benzimidazole- -H 871 410 4-(N-4'-carbonamido-5'-imidazolyl) H2N 85 amide H 0 H NHN 411 2-(2-piperidinyl)-1H-benzimidazole- N89 4-(N-4'-pyrazolyl)amide NH H 2-(2-piperidinyl)- 1H-benzimidazole- N 4-(N-2-pyrazinyl)amidedN HH 2-(2-piperidinyl)- 1H-benzimidazole- N2 413 4-(N-2-pyrzidnyl)amide N> H H 442-(2-piperidinyl)- 1H-benzimidazole- I1 454-(N-2-pyridnyl)amide N 9
H
111 H CH 3 2-(2-piperidinyl)- 1H-benzimidazole- N 93 416 4-(N-4-methyl-5-thiazolyl)amide N S H N H H 2-(2-piperidinyl)- 1H-benzimidazole- O N 417 4-(N-2,4-dihydroxyl-5-pyrimidinyl) \/88 amide N OH
OCH
3 2-(2-piperidinyl)- 1H-benzimidazole- H N H 418 4-(N-4,6-dimethoxy-2-pyrimidinyl)a N-1 / 93
OCH
3 CI 2-(2-piperidinyl)- 1H-benzimidazole- N H 419 4-(N-4-chloro-6-amino-2-pyrimidin N-<\ /89 yl)amide N
NH
2 CI 2-(2-piperidinyl)- 1H-benzimidazole- N 420 4-(N-4,6-dichloro-5-pyrimidinyl)am 93 ide N/ CI H H 421 2-(2-piperidinyl)- 1H-benzimidazole- N 92 4-(N-o-fluorophenyl)amide F 2-(2-piperidinyl)- 1H-benzimidazole- HH 422 4-(N-2-hydroxyl-4-pyrimidinyl)ami N 86 de deHO N H NH 423 2-(2-piperidinyl)- 1H-benzimidazole- N 91 4-(N-6-purinyl)amide OH HO 2-(2-piperidinyl)- 1H-benzimidazole- N 89 4-(N-6-hydroxyl-2-purinyl)amide H H 112 H 0 2 NH (L)-2-(3-piperidinyl)-1H-benzimidaz ON H OH 425 ole-4-[N-(1-hydroxymethyl-2-p-nitr H 93 ophenylhydroxyethyl)]amide HO NH H
H
2 N (L)-2-(3-piperidinyl)-1H-benzimidaz N H OH 426 ole-4-[N-(1-hydroxymethyl-2-p-ami H 90 nophenylhydroxyethyl)]amide H NH H H H 427 2-(3-piperidinyl)- 1H-benzimidazole- _,HN,,*C)9 4-(N-2-piperazinyl)amideN HI H HNH 428 2-(3-piperidinyl)- 1H-benzimidazole- N N 4-(N-2-pyrimidinyl)amide N N H (L)-2-(4-piperidinyl)-1H-benzimidaz H H 429 ole-4-[N-(-hydroxymethyl-2-p-nitr H NH ophenylhydroxyethyl)]amide yHO NHH
H
2 N N H (L)-2-(4-piperidinyl)-1H-benzimidaz H H OH 430 ole-4-[N-(1-hydroxymethyl-2-p-ami H 92 nophenylhydroxyethyl)]amide HO NH H 431 2-(4-piperidinyl)- 1H-benzimidazole- 91 4-(N-2-piperazinyl)amide H 432 2-(4-piperidinyl)- 1H-benzimidazole- 93 4-(N-2-pyrimidinyl)amide N N OgN H (L)-2-(3-indolyl)- 1H-benzimidazole- NH H2 HO H O10H 433 4-[N-(1-hydroxymethyl-2-p-nitrophe H 93 nylhydroxyethyl)]amide HO NH H 113
H
2 NH (L)-2-(3-indolyl)- 1H-benzimidazole- NH H H OH 434 4-[N-(1-hydroxymethyl-2-p-aminop H 88 henylhydroxyethyl)]amide H NH H HO 2-(3-indolyl)-1H-benzimidazole-4-[ NH H H 435 N-(1-methyl-2-p-chlorophenylhydro /r; H CH3 90 xyethyl)]amide HO NH H NH N 436 2-(3-indolyl)-1H-benzimidazole-4-( / N ' N 94 N-N'-piperidinyl)amide H NH HN * N) 437 2-(3-indolyl)-1H-benzimidazole-4-( 92 N-2-piperazinyl)amide N H NH N 2-(3-indolyl)-1H-benzimidazole-4-( 438 N-2'-benzimidazolyl)amide N H NH 440 2-(3-indolyl)-1H-benzimidazole-4-( NH 91 N-o-aminophenyl)amidemide NH NHH 440 2-(3-indolyl)-1H-benzimidazole-4-( / \ 88 N--benzimidazolonyl)amide H H N 2-(3-indolyl)- 1H-benzimidazole-4-( NHI-, I) 441 N-4' -calbonamido-5'-imidazolyl)am /\H2N N 9 ide H 0 H 422-(3 -indolyl)-l1H-benzimidazole-4-(NHN8 N-4' -pyrazolyl)amide
NH
114 2-(3-indolyl)-1H-benzimidazole-4-( NH H N-(N'-piperazinyl))amide N-N NH 89 NHN 444 2-(3-indolyl)-1H-benzimidazole-4-( /4 N-2-pyrazinyl)amide H NH 445 2-(3-indolyl)- 1H-benzimidazole-4-( /\92 N-2-pyrimidinyl)amide N N9 H NH 446 2-(3-indolyl)-1H-benzimidazole-4-( / 93 N-2-pyridyl)amideH NH CH 3 447 2-(3-indolyl)- 1H-benzimidazole-4-( N-4-methyl-5-thiazolyl)amide N 2-(3-indolyl)- 1H-benzimidazole-4-( NH N 448 N-2,4-dihydroxyl-5-pyrimidinyl)ami / N 87 de N H
OCH
3 2-(3-indolyl)- 1H-benzimidazole-4-( NH N_ H 449 N-4,6-dimethoxy-2-pyrimidinyl)ami N-<\ /93
OCH
3 CI 2-(3-indolyl)-1H-benzimidazole-4-( NH N_ H 450 N-4-chloro-6-amino-2-pyrimidinyl)a N-/\ / 88
NH
2 CI NH N 451 2-(3-indolyl)-1H-benzimidazole-4-( 92 N-4,6-dichloro-5-pyrimidinyl)amide / 92 N C cI 115 H NH N 452 2-(3-indolyl)- 1H-benzimidazole-4-( / N 94 N-o-fluorophenyl)amide NH NH 453 2-(3-indolyl)-1H-benzimidazole-4-( / \ 86 N-2-hydroxyl-4-pyrimidinyl)amide N HO N NH NH 454 2-(3-indolyl)-1H-benzimidazole-4-( / \ 90 N-6-purinyl)amide OH NH OH 2-(3-indolyl)-1H-benzimidazole-4-( 45 N6-yroyl2puinlamde-N N N 8 H H 0 2 N (L)-2-(2'-imidazolyl)- 1H-benzimida N H OH 456 zole-4-[N-(1-hydroxymethyl-2-p-nit I H 93 rophenylhydroxyethyl)]amide N HO H H2N (L)-2-(2'-imidazolyl)- 1H-benzimida I H H H 457 zole-4-[N-(1-hydroxymethyl-2-p-am H 93 inophenylhydroxyethyl)]amide N HO N H CI 2-(2'-imidazolyl)- 1H-benzimidazole H H 458 -4-[N-(1-methyl-2-p-chlorophenylhy CH3 88 droxyethyl)]amide NH NH H H N 459 2-(2'-imidazolyl)- 1H-benzimidazole N 93 -4-(N-N'-piperidinyl)amide H H -HN N) 2-(2'-imidazolyl)- 1H-benzimidazole HN9 -4-(N-2-piperazinyl)amide NN
H
116 H N 46 2-(2'-imidazolyl)- 1H-benzimidazole N -4-(N-2'-benzimidazolyl)amide / N N H HH H N 462 2-(2'-imidazolyl)- 1H-benzimidazole N 86 -4-(N-o-aminophenyl)amide N
NH
2 HH 463 2-(2'-imidazolyl)- 1H-benzimidazole 90 -4-(N-5-benzimidazolonyl)amide > N N N N H H H H ~ N N 2-(2'-imidazolyl)- 1H-benzimidazole N N 464 -4-(N-4'-carbonamido-5'-imidazolyl H2N / 86 )amide NH 0 H N N HI 2-(2'-imidazolyl)- 1H-benzimidazole NI 465 -4-(N-4'-pyrazolyl)amide // NNH HN 2-(2'-imidazolyl)- 1H-benzimidazole N-N N 466 -4-(N-(N'-piperazinyl))amide N NH 93 N H N 467 2-(2'-imidazolyl)- 1H-benzimidazole N -4-(N-2-pyrazinyl)amide NN N> H H 468 2-(2'-imidazolyl)- 1H-benzimidazole N N9 -4-(N-2-pyrimidinyl)amide N - N N H 469 2-(2'-imidazolyl)- 1H-benzimidazole NN 90 -4-(N-2-pyridyl)amide Kr IN9
H
117 H CH 3 2-(2'-imidazolyl)- 1H-benzimidazole N 470 -4-(N-4-methyl-5-thiazolyl)amide N N H H 2-(2'-imidazolyl)- 1H-benzimidazole N N 471 -4-(N-2,4-dihydroxyl-5-pyrimidinyl) HO/86 amide N OH
OCH
3 2-(2'-imidazolyl)- 1H-benzimidazole H N_ 472 -4-(N-4,6-dimethoxy-2-pyrimidinyl) N \ /94 amide N N
OCH
3 CI H N 2-(2'-imidazolyl)- 1H-benzimidazole H -4-(N-4-chloro-6-amino-2-pyrimidin N 86 yl)amide NH2 CI 2-(2'-imidazolyl)- 1H-benzimidazole N 474 -4-(N-4,6-dichloro-5-pyrimidinyl)a / KN 93 mide N N CI H H N 475 2-(2'-imidazolyl)- 1H-benzimidazole N 93 -4-(N-o-fluorophenyl)amide 2-(2'-imidazolyl)- 1H-benzimidazole NH 476 -4-(N-2-hydroxyl-4-pyrimidinyl)ami N Ode N H
N
H NH 477 2-(2'-imidazolyl)- 1H-benzimidazole N 93 -4-(N-6-purinyl)amide N N N N H OH 2-(2'-imidazolyl)- 1H-benzimidazole N 87 -4-(N-6-hydroxyl-2-purinyl)amide -N N N H H 118 0 2 NH (L)-2-(3-pyrazolyl)- 1H-benzimidazo OH OH 479 le-4-[N-(1-hydroxymethyl-2-p-nitro H 94 phenylhydroxyethyl)]amide HO NH H
H
2 N (L)-2-(3-pyrazolyl)- 1H-benzimidazo H OH 480 le-4-[N-(1-hydroxymethyl-2-p-amin H 86 ophenylhydroxyethyl)]amide H NH H HO CI 481 -[N-(1-methyl-2-p-chlorophenylhydr CH3 90 oxyethyl)]amide H N HH N H 482 2-(3-pyrazolyl)-1H-benzimidazole-4 N N 94 -(N-N'-piperidinyl)amide H H 2-(3-pyrazolyl)-1H-benzimidazole-4 H 483 -(N-2-piperazinyl)amide 93 N H H NN NH2 486 2-(3-pyrazolyl)-1H-benzimidazole-4 N 93 -(N-2'-benzimidazolyl)amide H HH 485 2-(3-pyrazolyl)-1H-benzimidazole-4 N88 -(N-o-aminophenyl)amide >aH HH 486 2-(3 -pyrazolyl)-l1H-benzimidazole-4 > , CN=o 9 -(N-S -benzimidazolonyl)amide N N HH H 2-(3-pyrazolyl)- 1H-benzimidazole-4 NN 487 -(N-4'-carbonamido-5'-imidazolyl)a H2N 87 mide H 0 119 H HN N 482-(3-pyrazolyl)- 1H-benzimidazole-4 94/ 48 -(N-4' -pyrazolyl)amide /9 N H H 2-(3-pyrazolyl)- 1H-benzimidazole-4 I NH 489 -(N-(N' -piperazinyl))amide I/N-N N H 86 40 2-(3 -pyrazolyl)- 1 H-benzimidazole-4 90N\ 40 -(N-2-pyrazinyl)amide I/"N9 H HH 42 2-(3-pyrazolyl)- 1H-benzimidazole-4 93N 41 -(N-2-pyridyl)amide N 8 H NN 492 (N-2pyriyl~aide N N H 2-(3-pyrazolyl)- 1H-benzimidazole-4 /_ NN HO N OH 3 3 2-(3-pyrazolv1')-1H-benzimidazole-4 N HH 494 -(N-4,4-dihydroxyl-5-pyrimidinyl)a HO /938 mide N
OCH
3 Hc 2-(3 -pyrazolyl)-l1H-benzimidazole-4 NN. I N H 495 -(N-4,-dimehoxyamn-2-pyrimidinyI N 88 9 )amiyde ll- Hbezmiaol- N.
NH
2 120 CI H 2-(3-pyrazolyl)- 1H-benzimidazole-4 N N 497 -(N-4,6-dichloro-5-pyrimidinyl)ami 94 de N C1 HH 498 2-(3-pyrazolyl)- 1H-benzimidazole-4 93 -(N-o-fluorophenyl)amide > -F H NH NN 499 2-(3-pyrazolyl)-1H-benzimidazole-4 N 90 -(N-2-hydroxyl-4-pyrimidinyl)amide N HO N H N NH 500 2-(3-pyrazolyl)- 1H-benzimidazole-4 86 -(N-6-purinyl)amide N N H OH H 2-(3-pyrazolyl)-1H-benzimidazole-4 N N N 501 -(N-6-hydroxyl-2-purinyl)amide N N >-NJ N) N) H H 0 2 N H (L)-2-(2-pyrimidinyl)-1H-benzimida N H OH NH 502 zole-4- [N- (1 -hydroxymethyl-2-p -nit H 3 rophenylhydroxyethyl)]amide N HO NH H
H
2 N (L)-2-(2-pyrimidinyl)-1H-benzimida N H H H H H 503 zole-4-[N-(1-hydroxymethyl-2-p-am H 88 inophenylhydroxyethyl)]amide N HO NH H 2-(2-pyrimidinyl)- 1H-benzimidazole N H H 504 -4-[N-(1-methyl-2-p-chlorophenylhy CH3\/C droxyethyl)]amide HO NH 121 H 505 2-2prmdnl-H-ezmdzl0 2-(2-pyrimidinyl)- 1H-benzimidazole N N 9 -4-(N-N'-piperidinyl)amide N9 H 572-(2-pyrimidinyl)- 1H-benzimidazole N -4-N-'-bnzmidzoylNmieN 506 2-(2-pyrimidinyl)-1H-benzimidazole N -4-(N-2-piperazinyl)amide N N H N N 2-(2-pyrimidinyl)- 1H-benzimidazole N92 510 -4-(N-2'-benzimidazolyl)amide N (DN H 2-(2-pyrimidinyl)- 1H-benzimidazole N 508 90 -4-(N-o-aminophenyl)amide N NH2 NH 2-(2-pyrimidinyl)- 1H-benzimidazole N NH 86 -4-(N-5-benzimidazolonyl)amide NH N H H H N 2-(2-pyrimidinyl)- 1H-benzimidazole N I 510 -4-(N-4'-carbonamido-5'-imidazolye N /)ZN / 87 N N )amide H H N -N 2-(2-pyrimidinyl)- 1H-benzimidazole N/ 511 93~ -4-(N-4' -pyrazoyamide ND NH 2-(2-pyrimidinyl)- 1H-benzimidazole N H____ 12-4-(N-(N' -piperazinyl))amide / ___NH 8 532-(2-pyrimidinyl)- 1H-benzimidazole N 9 53-4-(N-2-pyrazinyl)amide ND
H
122 514 2-(2-pyrimidinyl)- 1H-benzimidazole N 90 -4-(N-2-pyrimidinyl)amide N N N H 2-(2-pyrimidinyl)- 1H-benzimidazole N N -4-(N-2-pyridyl)amide N N H
CH
3 516 2-(2-pyrimidinyl)- 1H-benzimidazole N N -4-(N-4-methyl-5-thiazolyl)amide NDN S H N H 2-(2-pyrimidinyl)- 1H-benzimidazole N HO N 517 -4-(N-2,4-dihydroxyl-5-pyrimidinyl) HO/90 amide N N OH
OCH
3 2-(2-pyrimidinyl)- 1H-benzimidazole N N_ 518 -4-(N-4,6-dimethoxy-2-pyrimidinyl) 86 amide N
OCH
3 CI 2-(2-pyrimidinyl)- 1H-benzimidazole N N_ H 519 -4-(N-4-chloro-6-amino-2-pyrimidin N 93 yl)amideN
NH
2 CI 2-(2-pyrimidinyl)- 1H-benzimidazole N N 520 -4-(N-4,6-dichloro-5-pyrimidinyl)a \ 93 mide N CI 2-(2-pyrimidinyl)- 1H-benzimidazole N 521 93 -4-(N-o-fluorophenyl)amide NDF 2-(2-pyrimidinyl)- 1H-benzimidazole N NH 522 -4-(N-2-hydroxyl-4-pyrimidinyl)ami \N N 88 de N HO N 123 NH 523 2-(2-pyrimidinyl)- 1H-benzimidazole N -4-(N-6-purinyl)amide NN N N H OH 2-(2-pyrimidinyl)- 1H-benzimidazole N N N 524 -4-(N-6-hydroxyl-2-purinyl)amide N -N N N H H (L)-2-(2-phenyl-5-pyrimidinyl)- 1H- N 02N H 525 benzimidazole-4-[N-(1-hydroxymet H OH H hyl-2-p-nitrophenylhydroxyethyl)]a N NH mide HO H H2N (L)-2-(2-phenyl-5-pyrimidinyl)-1H- H 526 benzimidazole-4-[N-(1-hydroxymet H OH hyl-2-p-aminophenylhydroxyethyl)] NH amide HO H CI 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ H 527 imidazole-4-[N-(1-methyl-2-p-chlor - CH3 86 ophenylhydroxyethyl)]amide HO NH N. H 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ N 528 imidazole-4-(N-N'-piperidinyl)amid - / D 93 e H N. H N,* N 529 2-(2-phenyl-5-pyrimidinyl)- 1H-benz /N H 93 imidazole-4-(N-2-piperazinyl)amide N N H 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \N H 530 imidazole-4-(N-2'-benzimidazolyl)a ) N 88 mide H 124 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ N 531 imidazole-4-(N-o-aminophenyl)ami - > / 93 de
NH
2 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ N 532 imidazole-4-(N-5-benzimidazolonyl) - > 90 N N amide H H H NN N 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / 533 imidazole-4-(N-4'-carbonamido-5'-i - N H 2 N 94 N midazolyl)amide H H 534 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ N 90 imidazole-4-(N-4'-pyrazolyl)amide N N N NH 2-(2-phenyl-5-pyrimidinyl)- 1H-benz NH 535 imidazole-4-(N-(N'-piperazinyl))ame N N NH 90 ide 536 2-(2-phenyl-5-pyrimidinyl)-1H-benz N imidazole-4-(N-2-pyrazinyl)amide N H 2-(2-phenyl-5-pyrimidinyl)-1H-benz / \ N N 539 imidazole-4-(N-2-pyrimidinyl)amide N N N3 H 582-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ D 58imidazole-4-(N-2-pyridyl)amide N - /t9 N 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / N........C 3 8 539 imidazole-4-(N-4-methyl-5-thiazolyl 88 )amide 125 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ H N 540 imidazole-4-(N-2,4-dihydroxyl-5-py - \ /-N 93 rimidinyl)amide OH
OCH
3 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \N 541 imidazole-4-(N-4,6-dimethoxy-2-py - 90 rimidinyl)amide N
OCH
3 CI 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \N 542 imidazole-4-(N-4-chloro-6-amino-2- -- \ 94 pyrimidinyl)amide N
NH
2 CI 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ N N 543 imidazole-4-(N-4,6-dichloro-5-pyri - / / 94 midinyl)amide N CI 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ N 544 imidazole-4-(N-o-fluorophenyl)amid - N 90 e F 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ N NH 545 imidazole-4-(N-2-hydroxyl-4-pyrimi - N N 86 dinyl)amide HO N NN 546 2-(2-phenyl-5-pyrimidinyl)- 1H-benz N NH 93 imidazole-4-(N-6-purinyl)amide N N N H OH 2-(2-phenyl-5-pyrimidinyl)- 1H-benz / \ 547 imidazole-4-(N-6-hydroxyl-2-puriny N N 93 1)amide H H (L)-2-(4-amino-6-chloro-5-pyrimidi NH2 02N H 548 nyl)-1H-benzimidazole-4-[N-(1-hyd N H OH H roxymethyl-2-p-nitrophenylhydroxy H ethyl)]amide ci HO H 126 (L)-2-(4-amino-6-chloro-5-pyrimidi NH2 H2N H nyl)- 1H-benzimidazole-4-[N-(1-hyd H OH roxymethyl-2-p-aminophenylhydrox H yethyl)]amide cI HO N H
NH
2 CI 2-(4-amino-6-chloro-5-pyrimidinyl)- N_ H H 550 1H-benzimidazole-4-[N-(1-methyl-2- /CH3 90 p-chlorophenylhydroxyethyl)] amide N H NH
NH
2 H 2-(4-amino-6-chloro-5-pyrimidinyl)- N- N N 551 1H-benzimidazole-4-(N-N'-piperidi 94 nyl)amide NCI
NH
2 H 2-(4-amino-6-chloro-5-pyrimidinyl)- N_ HN N 552 1H-benzimidazole-4-(N-2-piperazin 86 yl)amide N N CI H
NH
2 2-(4-amino-6-chloro-5-pyrimidinyl)- N N H 553 1H-benzimidazole-4-(N-2'-benzimid N/ 90 N- N azolyl)amide H cI 2-(4-amino-6-chloro-5-pyrimidinyl)- NH2 N 554 1H-benzimidazole-4-(N-o-aminophe / 86 nyl)amide N NH 2
NH
2 2-(4-amino-6-chloro-5-pyrimidinyl)- N- N 555 1H-benzimidazole-4-(N-5-benzimid 93 azolonyl)amide N CH IC NH2 H 2-(4-amino-6-chloro-5-pyrimidinyl)- N N N 556 1H-benzimidazole-4-(N-4'-carbona H2 N 86 / N mido-5'-imidazolyl)amide N C H CI 0 H
NH
2 N N 2-(4-amino-6-chloro-5-pyrimidinyl)- N- / 557 1H-benzimidazole-4-(N-4'-pyrazoly 88 1)amide N NH CI N 127
NH
2 2-(4-amino-6-chloro-5-pyrimidinyl)- NH 558 1H-benzimidazole-4-(N-(N'-piperaz N-N NH 93 inyl))amide N CI cI
NH
2 N 2-(4-amino-6-chloro-5-pyrimidinyl)- N 559 1H-benzimidazole-4-(N-2-pyrazinyl 90 )amide N N N cI H
NH
2 2-(4-amino-6-chloro-5-pyrimidinyl)- N N 560 1H-benzimidazole-4-(N-2-pyrimidin 90 yl)amide N C N N cl H
NH
2 2-(4-amino-6-chloro-5-pyrimidinyl)- N N 561 1H-benzimidazole-4-(N-2-pyridyl)a 86 mide N CN H
NH
2 2-(4-amino-6-chloro-5-pyrimidinyl)- N N 562 1H-benzimidazole-4-(N-4-methyl-5- 90 thiazolyl)amide NCI
NH
2 N 2-(4-amino-6-chloro-5-pyrimidinyl)- NH H 563 1H-benzimidazole-4-(N-2,4-dihydro HO-H \ N 86 xyl-5-pyrimidinyl)amide N/ / cl OH
OCH
3
NH
2 2-(4-amino-6-chloro-5-pyrimidinyl)- N N_ / H 564 1H-benzimidazole-4-(N-4,6-dimetho N 90 xy-2-pyrimidinyl)amide N cI
OCH
3 CI
NH
2 2-(4-amino-6-chloro-5-pyrimidinyl)- N N_ / H 565 1H-benzimidazole-4-(N-4-chloro-6- N 90 amino-2-pyrimidinyl)amide N
NH
2 CI
NH
2 2-(4-amino-6-chloro-5-pyrimidinyl)- N N 566 1H-benzimidazole-4-(N-4,6-dichlor N 88 o-5-pyrimidinyl)amide N CI
CI
128 NH2 H 2-(4-amino-6-chloro-5-pyrimidinyl)- N N 567 1H-benzimidazole-4-(N-o-fluorophe 93 nyl)amide N CI F NH2 2-(4-amino-6-chloro-5-pyrimidinyl)- N NH 568 1H-benzimidazole-4-(N-2-hydroxyl- N 90 4-pyrimidinyl)amide N HO N
NH
2 NH 2-(4-amino-6-chloro-5-pyrimidinyl)- N 569 1H-benzimidazole-4-(N-6-purinyl)a / N N 91 mide NN ci Nzz N H
NH
2 OH 2-(4-amino-6-chloro-5-pyrimidinyl)- N 570 1H-benzimidazole-4-(N-6-hydroxyl- N N 93 2-purinyl)amide -N N N cI H H (L)-2-(2-pyrrolidine-1-yl-5-pyrimidi N 02N H 57 nyl)-1H-benzimidazole-4-[N-(1-hyd N H OH H roxymethyl-2-p-nitrophenylhydroxy NH ethyl)]amide HO H (L)-2-(2-pyrrolidine-1-yl-5-pyrimidi N H2N H 572 nyl)-lH-benzimidazole-4-[N-(1-hyd N H OH H roxymethyl-2-p-aminophenylhydrox N yethyl)]amide HO H 2-(2-pyrrolidine-1-yl-5-pyrimidinyl) N C ) H 573 -1H-benzimidazole-4-[N-(1-methyl- QN H94 2-p-chlorophenylhydroxyethyl)]ami NHC de HO N IN 2-(2-pyrrolidine-1-yl-5-pyrimidinyl) CN HN 574 -1H-benzimidazole-4-(N-N'-piperidi N- 92 nyl)amide 129 H 2-(2-pyrrolidine- 1l-yl-5 -pyrimidinyl) N H N,* N 575 -1H-benzimidazole-4-(N-2-piperazin N" 94 yl)amide N H 576 -1H-benzimidazole-4-(N-2' -benzimi N 94 dazolyl)amide H N H 2-(2-pyrrolidine- 1-yl-5-pyrimidinyl) IN-- N 577 -1H-benzimidazole-4-(N-o-aminoph N 93 enyl)amide aNH 2 2-(2-pyrrolidine- 1 -yl-5-pyrimidinyl) /N N H /N- :\ 578 -1 H-benzimidazole-4-(N-5 -benzimid N "CN= 90 N N azolonyl)amide H H H 2-(2-pyrrolidine- 1 -yl-5-pyrimidinyl) IN N N 579 - 1H-benzimidazole-4-(N-4' -carbona N ~ H2N 285 N mido-5' -imidazolyl)amide H 0 H 2-(2-pyrrolidine- l-yl-S -pyrimidinyl) N N 580 -1 H-benzimidazole-4-(N-4' -pyrazol 93 yl)amide NH\ 2-(2-pyrrolidine-1-yl-5-pyrimidinyl) N 581 -1H-benzimidazole-4-(N-(N'-pipera N- N NH 93 zinyl))amide 2-(2-pyrrolidine- l-yl-S -pyrimidinyl) NN 582 - 1H-benzimidazole-4-(N-2-pyraziny N~ ~ 88 1)amideN N H 2-(2-pyrrolidine-1-yl-5-pyrimidinyl) N N 583 -1 H-benzimidazole-4-(N-2-pyrimidi N -" )-89 nyl)amide N N
H
130 2-(2-pyrrolidine- 1 -yl-5-pyrimidinyl) N N 584 -1H-benzimidazole-4-(N-2-pyridyl)a N _1 87 mide "N H 2-(2-pyrrolidine- 1l-yl-S -pyrimidinyl) /N N: N CH 585 -1H-benzimidazole-4-(N-4-methyl-5 N(/ \92 -thiazolyl)amide N 2-(2-pyrrolidine- 1l-yl-S -pyrimidinyl) N _< 586 -1H-benzimidazole-4-(N-2,4-dihydr N90 oxyl-5 -pyrimidinyl)amide N H
OCH
3 2-(2-pyrrolidine- 1 -yl-5-pyrimidinyl) cN N N H 587 -1H-benzimidazole-4-(N-4,6-dimeth N N - / 91 oxy-2-pyrimidinyl)amide N/ OCH3 cI 2-(2-pyrrolidine- 1 -yl-5-pyrimidinyl) N N__ N-- H 588 -1H-benzimidazole-4-(N-4-chloro-6- N N \ 93 amino-2-pyrimidinyl)amide N
NH
2 2-(2-pyrrolidine- 1 -yl-5-pyrimidinyl) 1\N N: N-c 589 -1H-benzimidazole-4-(N-4,6-dichlor N~~/~ 93 o-5 -pyrimidinyl)amide N 2-(2-pyrrolidine- 1-yl-5-pyrimidinyl) N 590 -1H-benzimidazole-4-(N-o-fluoroph NF94 enyl)amide a 591 -1H-benzimidazole-4-(N-2-hydroxyl N N 90 -4-pyrimidinyl)amide
OJ:
522-(2-pyrrolidine- 1l-yl-S -pyrimidinyl) N NN mideN N
H
131 OH 2-(2-pyrrolidine- 1 -yl-5-pyrimidinyl) j, N N 9 593 -1H-benzimidazole-4-(N-6-hydroxyl N~ N 9 -2-purinyl)amide N Nr H H (L)-2-(2-pipenidine- l-yl-5 -pynimidin /- N O2N 'C * H yl)-1H-benzimidazole-4-[N-(1-hydr K>-K \ H O_ HH 594 H_ 91 oxymethyl-2-p-nitrophenylhydroxye \ XH thyl)] amide HO / H (L)-2-(2-piperidine- l-yl-S -pyrimidin ,- NN H yl-HA 0 enzi1iazoe--NL(l1-hydr N-i' H OHH 595 NL1c1tf tJ1,r. 91 oxymethyl-2-p-aminophenylhydroxy NH ethyl)] amide HO / H 2-(2-piperidine- 1l-yl-S -pyrimidinyl)- 1 C) H 596 H-benzimidazole-4-[N-(1-methyl-2-p NH CH3 93 -chlorophenylhydroxyethyl)] amide HO NH C N N\H 2-(2-piperidine- 1-yl-5-pyrimidinyl)- y _N -1N 597 1H-benzimidazole-4-(N-N' -piperidi N9 nyl)amide N HN, 2-(2-piperidine- 1-yl-5-pyrimidinyl)- ('N '\ HN N 598 1H-benzimidazole-4-(N-2-piperazin N 93 yl)amideN H 2-(2-piperidine- 1-yl-5-pyrimidinyl)- INN: 599 H-enziidaole4-(N2' benimid ~ N-I 9 N 600 1H-benzimidazole-4-(N-o'-aemipN 92 nzyl)amide H 2-(2-piperidine- 1 -yl-5-pyrimidinyl)- N-N 601 1H-benzimidazole-4-(N-5-benzimid N 92 azolonyl)amide N H 132 2-(2-piperidine- 1 -yl-5-pyrimidinyl)- N 602 1H-benzimidazole-4-(N-4'-carbona N H2N N 85 mido-5'-imidazolyl)amide H 0 H 2-(2-piperidine-1-yl-5-pyrimidinyl)- ( N N:\ NN 603 1H-benzimidazole-4-(N-4'-pyrazoly N- 94 1)amide NH 2-(2-piperidine-1-yl-5-pyrimidinyl)- N 604 1H-benzimidazole-4-(N-(N'-piperaz N--N NH 90 inyl))amide 2-(2-piperidine-1-yl-5-pyrimidinyl) C N: N l 605 1H-benzimidazole-4-(N-2-pyrazinyl N 94 )amide H 2-(2-piperidine-1-yl-5-pyrimidinyl)- N N 606 1H-benzimidazole-4-(N-2-pyrimidin N 92 yl)amide N 2-(2-piperidine-1-yl-5-pyrimidinyl)- N 607 1H-benzimidazole-4-(N-2-pyridyl)a N N mide H 2-(2-piperidine-1-yl-5-pyrimidinyl)- N N CH 608 1H-benzimidazole-4-(N-4-methyl-5- N 94 thiazolyl)amide S H 2-(2-piperidine-1-yl-5-pyrimidinyl)- N H N H. 609 1H-benzimidazole-4-(N-2,4-dihydro N 93 xyl-5-pyrimidinyl)amide OH OCH3 2-(2-piperidine-1-yl-5-pyrimidinyl)- N 610 1H-benzimidazole-4-(N-4,6-dimetho N H 90 xy-2-pyrimidinyl)amide N O OCH, 133 CI 2-(2-piperidine- 1 -yl-5-pyrimidinyl)- NH N_ 611 1H-benzimidazole-4-(N-4-chloro-6- N N\ 91 amino-2-pyrimidinyl)amide N NH2 CI 2-(2-piperidine-1-yl-5-pyrimidinyl)- N N 612 1H-benzimidazole-4-(N-4,6-dichlor N93 o-5-pyrimidinyl)amide NZ CI 2-(2-piperidine-1-yl-5-pyrimidinyl)- _N N 613 1H-benzimidazole-4-(N-o-fluorophe N- 93 nyl)amide F 2-(2-piperidine-1-yl-5-pyrimidinyl)- ( N NH 614 1H-benzimidazole-4-(N-2-hydroxyl- N 88 4-pyrimidinyl)amide HO N 2-(2-piperidine-1-yl-5-pyrimidinyl)- NH 615 1H-benzimidazole-4-(N-6-purinyl)a N N N 89 mide N N 2-(2-piperidine- 1-yl-5-pyrimidinyl)- N OH 616 1H-benzimidazole-4-(N-6-hydroxyl- N 87 2-purinyl)amide -N N N H H (L)-2-(2-cyclopropylamino-5-pyrimi N 02N H dinyl)-1H-benzimidazole-4-[N-(1-hy >-NH--< \ H OH H droxymethyl-2-p-nitrophenylhydrox NH yethyl)]amide HO H (L)-2-(2-cyclopropylamino-5-pyrimi N H2N H dinyl)-1H-benzimidazole-4-[N-(1-hy >-NH- H OH 618 H 90 droxymethyl-2-p-aminophenylhydro NH xyethyl)]amide HO H 2-(2-cyclopropylamino-5-pyrimidin N cl H 619 yl)-l H-benzimidazole-4-[N-(1-meth >-NH--< \ H yl-2-p-chlorophenylhydroxyethyl)]a NCH3 mide H 134 N H 2-(2-cyclopropylamino-5-pyrimidin > N_ N 620 yl)-l1 H-benzimidazole-4-(N-N' -piper N9 idinyl)amide C N H 2-(2-cyclopropylamino-5-pyrimidin >-NH</ HN ,,N) 621 yl)-l1 H-benzimidazole-4-(N-2-pipera N -93 zinyl)amideN 2-(2-cyclopropylamino-5-pyrimidin N:K/\ N ... H 622 yl)-l1 H-benzimidazole-4-(N-2' -benzi N 94 midazolyl)amide H 2-(2-cyclopropylamino-5 -pyrimidin >-NHK/ N 623 yl)-1H-benzimidazole-4-(N-o-amino N~90 phenyl)amide NH2 NI 2-(2-cyclopropylamino-5-pyrimidin N:K/\ N 624 yl)-l1 H-benzimidazole-4-(N-5 -benzi N 93 midazolonyl)amide H H H 2-(2-cyclopropylamino-5-pyrimidin >NH< N\ll 625 yl)-l H-benzimidazole-4-(N-4' -carbo NH2N )92 namido-5' -imidazolyl)amide H 0 H 2-(2-cyclopropylamino-5-pyrimidin > N:-</\ N 626 yl)-l H-benzimidazole-4-(N-4' -pyraz y _/ 91 olyl)amide NH 2-(2-cyclopropylamino-5-pyrimidin >NH< N\ H 627 yl)-1H-benzimidazole-4-(N-(N'-pipe N N-/ NH 91 razinyl))amide 2-(2-cyclopropylamino-5-pyrimidin N:\~ N 628 yl)-l H-benzimidazole-4-(N-2-pyrazi N ~ I)9 nyl)amide H 135 2-(2-cyclopropylamino-5-pyrimidin >-NHK/ N 629 yl)-1H-benzimidazole-4-(N-2-pyrim N:- IN' 92 idinyl)amide H 2-(2-cyclopropylamino-5-pyrimidin >-NHK/ N 630 yl)-l H-benzimidazole-4-(N-2-pyridy N:) -19 1)amide H 2-(2-cyclopropylamino-5-pyrimidin NCH 631 yl)-l H-benzimidazole-4-(N-4-methy 94 1-5 -thiazolyl)amide 2-(2-cyclopropylamino-5-pyrimidin N H 632yl)lHbenimdazle4-(-24-dhy>-NH-K/\ O-\9 N droxyl-5 -pyrimidinyl)amide O
OCH
3 2-(2-cyclopropylamino-5 -pyrimidin NH~ N N. 633 yl)-l H-benzimidazole-4-(N-4,6-dim Y\ - N- 92 ethoxy-2-pynimidinyl)amide N Z
OCH
3 cI 2-(2-cyclopropylamino-5 -pyrimidin hNHJ N N. 634 yl)-l H-benzimidazole-4-(N-4-chloro Y\ - - N- 93 -6-amino-2-pynimidinyl)amide N X
NH
2 CI 2-(2-cyclopropylamino-5-pyrimidin >NH< N\ N 635 yl)-l H-benzimidazole-4-(N-4,6-dich N -N94 loro-5 -pyrimidinyl)amide NX CI 2-(2-cyclopropylamino-5-pyrimidin > NH- H_ 636 yl)-l H-benzimidazole-4-(N-o-fluoro N~ 90 phenyl)amide a 2-(2-cyclopropylamino-5-pyrimidin >NH< N NH 637 yl)-l H-benzimidazole-4-(N-2-hydro NCY 94 xyl-4-pyrimidinyl)amide 136 2-(2-cyclopropylamino-5-pyrimidin >NHK/ _H 638 yl)-1H-benzimidazole-4-(N-6-puriny N N N 92 1)amide N N OH 2-(2-cyclopropylamino-5-pyrimidin NH 639 yl)-lH-benzimidazole-4-(N-6-hydro N N N 9 xyl-2-purinyl)amide N N H H (L)-2-(1,3-dimethyl-5-chloro-4-pyra Cl CH, O2N H zolyl)-1H-benzimidazole-4-[N-(1-hy N H OH 640 N H 94 droxymethyl-2-p-nitrophenylhydrox NH yethyl)]amide CH 3 HO H (L)-2-(1,3-dimethyl-5-chloro-4-pyra Cl CH, H2N H zolyl)-1H-benzimidazole-4-[N-(1-hy N H OH 641 N H 93 droxymethyl-2-p-aminophenylhydro xyethyl)]amide CH 3 HO H 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH, H 1)- H-benzimidazole-4-[N-(1-methyl H 64 -2-p-chlorophenylhydroxyethyl)ami N NH CH3 90 de CH 3 H Cl ,CH, 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 N 643 1)-1H-benzimidazole-4-(N-N'-piperi N 91 dinyl)amide
CH
3 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 HN N 644 1)- 1H-benzimidazole-4-(N-2-piperaz N93 inyl)amide CH 3 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH 3 N H 645 1)-1H-benzimidazole-4-(N-2'-benzi N 93 N midazolyl)amide CH, H 137 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 646 1)-1H-benzimidazole-4-(N-o-aminop N 88 henyl)amide
CH
3 NH 2 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 647 1)- 1H-benzimidazole-4-(N-5-benzim N 89 idazolonyl)amide CH3 H 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 N 648 1)-1H-benzimidazole-4-(N-4'-carbon N H2N N 87 amido-5'-imidazolyl)amide CH3 0 H H 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 N N 649 1)- 1H-benzimidazole-4-(N-4'-pyrazo 92 lyl)amide
CH
3 NH 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 H 650 1)-1H-benzimidazole-4-(N-(N'-piper N N--N NH 90 azinyl))amide
CH
3 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 N 651 1)- 1H-benzimidazole-4-(N-2-pyrazin N 91 yl)amide CH 3 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 N 652 1)- 1H-benzimidazole-4-(N-2-pyrimi N 93 dinyl)amide CH3 H 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 N 653 1)- 1H-benzimidazole-4-(N-2-pyridyl N 93 )amide CHN 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH 3 N CH 654 1)-1H-benzimidazole-4-(N-4-methyl- 94 5-thiazolyl)amide
CH,
138 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CHN HO N 655 1)-1H-benzimidazole-4-(N-2,4-dihyd N 90 roxyl-5-pyrimidinyl)amide CH, OH
OCH
3 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 N____ H 93 656 1)-1H-benzimidazole-4-(N-4,6-dimet N N hoxy-2-pyrimidinyl)amide CH, N OCH3 2-(1,3-dimethyl-5-chloro-4-pyrazoly
CH
3 N c H 9 657 1)- 1H-benzimidazole-4-(N-4-chloro- N N \ 92 6-amino-2-pyrimidinyl)amide CH, N
NH
2 Cl ciH 2-(1,3-dimethyl-5-chloro-4-pyrazoly gCH3 N 658 1)-1H-benzimidazole-4-(N-4,6-dichl N 91 oro-5-pyrimidinyl)amide
CH
3 N cI 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 659 1)- 1H-benzimidazole-4-(N-o-fluorop N91 henyl)amide
CH
3 F 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 NH 660 1)- 1H-benzimidazole-4-(N-2-hydrox NN 93 yl-4-pyrimidinyl)amide CH, HO N 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 NH 661 1)-1H-benzimidazole-4-(N-6-purinyl N N 92 )amide
CH
3 ':N N H OH 2-(1,3-dimethyl-5-chloro-4-pyrazoly Cl CH3 662 1)- 1H-benzimidazole-4-(N-6-hydrox NN N 93 yl-2-purinyl)amide CH, N N N H H 663 2-(4-hydroxyphenyl)- 1H-benzimida OH 94 zole-4-(N-o-fluorophenyl)amide \ / 139 0 2 N (L)-2-(3-hydroxyphenyl)- 1H-benzim H OH 664 idazole-4-[N-(1-hydroxymethyl-2-p- \ / H 92 nitrophenylhydroxyethyl)]amide OH HO NH H OH 2-(3-hydroxyphenyl)- 1H-benzimida 665 zole-4-(N-6-hydroxyl-2-purinyl)ami \ / N 92 de OH - N N- N N H H Structure Identification of Product (refer to Figures 3-6): (23)2-(2-pyridyl)-1H-benzimidazole-4-N-hydroxyethylamide 1 HNMR (DMSO, 400MHz) 6: 3.64-3.67(t,1H), 3.73-3.75(m,2H), 4.39-4.42(t,2H), 7.32-7.36(t,1H), 7.38-7.40(t,1H), 7.73-7.75(d,1H), 7.80-7.81(d,1H), 7.85-7.86(t,1H), 8.38-8.40(d,1H), 8.59-8.61(d,1H); (24) 2-(2-pyridyl)-1H-benzimidazole-4-N-o-hydroxyphenylcarboxylamide 1 HNMR (DMSO, 400MHz) 6: 5.35(s,1H), 7.13(s,1H), 7.15-7.16(d,2H), 7.34-7.36(t,3H), 7.37-7.39(t,1H), 7.83-7.84(d,1H), 7.85-7.86(t,1H), 7.91-7.92(d,1H), 8.11-8.12(d,1H), 8.38-8.40(d,1H), 8.59-8.61(d,1H); (25) 2-(2-hydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.35(s,1H), 6.59-6.61(d,1H), 6.63-6.64(t,1H), 6.95-6.97(t,1H), 6.99-7.00(d,1H), 7.01-7.02(d,1H), 7.07-7.09(t,1H), 7.24-7.25(t,1H), 7.37-7.39(t,1H), 7.62-7.63(d,1H), 7.83-7.84(d,1H), 7.91-7.92(d,1H); (26)(L)-2-(2-hydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxyl-2-p-nitrophenylhydr oxyethyl)]amide 1 HNMR (DMSO, 400MHz) 6: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 5.3 5(s, 1H), 7.01-7.02(d,1H), 7.07-7.09(t,1H), 7.24-7.25(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.66-7.67(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (27)2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.46(t,1H), 7.70-7.72(d,1H), 7.89-7.91(d,1H), 7.93-7.95(d,1H), 8.30-8.33(d,1H), 8.57-8.60(d,1H), 11.53(s,1H); (28)2-(5-nitro-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide(refer to Figure 3) 1 HNMR(DMSO,400MHz)6:7.13-7.19(m, 1H),7.23-7.27(t, 1H),7.36-7.4 1 (t, 1H),7.50-7.5 4(m,2H), 7.85-7.87(d,1H), 7.94-7.95(d,1H), 8.05-8.07(d,1H), 8.57-8.61(t,1H), 12.19-12.20(d,1H), 14.25(s,1H); 140 (29)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.33(s,1H), 5.35(s,1H), 5.38(s,1H), 6.59-6.61(d,1H), 6.63-6.64(t,1H), 6.71(s,2H), 6.95-6.97(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (30)2-(3,4,5-trihydroxyphenyl)-1H-benzimidazole-4-(N-hydroxyethyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.33(s,1H), 5.35(s,1H), 5.38(s,1H), 2.84-2.88(m,2H), 3.59-3.62(m,2H), 3.65-3.67(t,1H), 6.71(s,2H), 7.43-7.45(t,1H), 7.89-7.90 (d,1H), 7.93-7.94(d,1H); (31)2-(2-piperidinyl)-1H-benzimidazole-4-(4-N'-ethyl-N-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.02-1 .05(t,3H), 1.43-1 .44(m, 1H), 1.45-1 .47(m,1H), 1.49-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(mlH), 1 .91-1.94(m,1H), 2.38-2.40(m,2H), 2.50-2.52(t,4H), 2.65-2.67(t,4H), 2.69-2.72(m, 1H), 2.79-2.8 1(m,1H), 4.02-4.04(m, 1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (32)2-(2-pyridyl)-1H-benzimidazole-4-(4-N'-ethyl-N-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.02-1 .05(t,3H), 2.3 8-2.40(m,2H), 2.50-2.52(t,4H), 2.65-2.67(t,4H), 7.36-7.38(t,H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.39(d,1H), 8.59-8.61(d,1H); (33)(L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nit rophenylhydroxyethyl)1 amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.17-3.18(m,1H), 3. 19-3.20(d,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (34)(L)-2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-am inophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.17-3.18(m,1H), 3. 19-3.20(d,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 5.13-5. 15(t,1H), 5.20-5.23(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (35)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhy droxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3. 19-3.20(d, 1H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t, 1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); 141 (36) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.OO-2.06(t,4H), 3.1O-3.15(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (37) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N- 2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 1.91-1.93(m,2H), 2.O-2.06(t,4H), 2.62-2.63(m, 1H), 2.65-2.66(m, 1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3. 19-3.20(d,1H), 3.99-4.O1(m,1H), 5.13-5. 15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (38) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.OO-2.06(t,4H), 3.19-3.20(d,1H), 5. 13-5.15(t,1H), 5.20-5.23(t,1H), 7.12-7. 15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (39) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.OO-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5. 15(t,1H), 5.20-5.23(t,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (40) 2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.O-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5. 15(t,1H), 5.20-5.23(t,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (41)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazoly )amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.OO-2.06(t,4H), 3.19-3.20(d,1H), 5. 13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.O-13.03(d,1H); (42)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5. 13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (43)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 1.91-1.95(m,1H), 142 2.O-2.06(t,4H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3. 19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (44)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.OO-2.06(t,4H), 3.19-3.20(d,1H), 5. 13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (45)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.O-2.06(t,4H), 3.19-3.20(d,1H), 5. 13-5.15(t,1H), 5.20-5.23(t,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (46)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.OO-2.06(t,4H), 3.19-3.20(d,1H), 5. 13-5.15(t,1H), 5.20-5.23(t,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (47)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.OO-2.06(t,4H), 2.45(s,3H), 3. 19-3.20(d,1H), 5.13 -5.15 (t, 1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H); (48)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl) amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.OO-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5. 15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (49)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl) amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.O-2.06(t,4H), 3.19-3.20(d,1H), 3.82(s,6H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (50)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidin yl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5. 15(t,1H), 5.20-5.23(t,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); 143 (51)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)a mide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.OO-2.06(t,4H), 3.19-3.20(d,1H), 5. 13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (52)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.O-2.06(t,4H), 3.19-3.20(d,1H), 5. 13-5.15(t,1H), 5.20-5.23(t,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (53)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)ami de 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5.13-5.15(t,1H), 5.20-5.23(t,1H), 5.46-5.48(d,1H), 7.10-7. 11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (54)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5. 13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8. 18(d,1H); (55)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-6-hydroxy-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.70(s,1H), 1.82(s,1H), 1.85(s,1H), 2.00-2.06(t,4H), 3.19-3.20(d,1H), 5. 13-5.15(t,1H), 5.20-5.23(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (56)(L)-2-(2-thienyl)-1H-benzimidzzole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyet hyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7. 17-7.19(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8. 17-8.20(d,2H); (57)(L)-2-(2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxy ethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7. 17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 144 7.89-7.90(d,1H), 7.93-7.95(d,1H); (58)2-(2-thienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.17-7. 19(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (59)2-(2- thienyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 7. 17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (60)2-(2- thienyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (61)2-(2- thienyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.12-7. 15(d,2H), 7.17-7. 19(t,1H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (62)2-(2- thienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (63)2-(2- thienyl)-1H-benzimidazole-4-(N-5- benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (64)2-(2- thienyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H); (65)2-(2- thienyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); 145 (66)2-(2- thienyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (67)2-(2- thienyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (68)2-(2- thienyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.17-7.19(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (69)2-(2- thienyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (70)2-(2- thienyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H); (71)2-(2- thienyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.82(s,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (72)2-(2- thienyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (73)2-(2- thienyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.74(s,2H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (74)2-(2- thienyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (75)2-(2- thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 146 6.99-7.O1(d,1H), 7.17-7. 19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (76)2-(2- thienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 7.1O-7.11(d,1H), 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.82(s,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (77)2-(2- thienyl)-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.86(d,1H), 7.87-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 16-8.18(d,1H); (78)2-(2- thienyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.17-7.19(t,1H), 7.43-7.45(t,1H), 7.69-7.71(d,1H), 7.85-7.87(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (79)(L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitropheny hydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.49-8.51(d,1H); (80)(L)-2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminopheny lhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 3.83(s,3H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.3 1 (s, 1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H) , 8.49-8.51(d,1H); (81)2-(4-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyeth ylflamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,3H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.3 1(s,1H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.5 1(d,1H); (82)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 3.83(s,3H), 7.3 1(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H); 147 (83)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m, 1H), 3.83(s,3H), 3.99-4.O1(m,1H), 7.3 1(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H); (84)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.5 1(d,1H); (85)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.3 1(s, 1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.5 1(d,1H); (86)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 6.35-6.37(d,1H), 6.93(s,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H); (87)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.49-8.5 1(d,1H), 9.24-9.26(d,1H), 13.O-13.03(d,1H); (88)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.5 1(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (89)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,3H), 7.3 1(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H); (90)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.49-8.51(d,1H); (91)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 148 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 6.93-6.95(t, 1H), 7.3 1(s, 1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 8.49-8.51(d,1H); (92)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.3 1(s, 1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.49-8.5 1(d,1H); (93)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.49-8.5 1(d,1H); (94)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.49-8.51(d,1H), 11.53(s,1H); (95)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 3.85(s,3H), 5.71(s,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.5 1(d,1H); (96)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.98(s,1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.5 1(d,1H); (97)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.5 1(d,1H), 9.34(s,1H); (98)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.3 1(s, 1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.5 1(d,1H); (99)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.46-5.48(d, 1H), 7.10-7.1 1(d, 1H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.51(d,1H); (100)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide 149 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.49-8.51(d,1H); (1O1)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 7.31(s,1H), 7.43-7.45(t,1H), 7.59-7.61(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.49-8.5 1(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (102)(L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitropheny hydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 3.80(s,1H), 4.73-4.77(t, 1H), 6.50-6.52(d,1H), 7.3 8-7.40(d,1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.72-7.74(t,1H), 7.89-7.90(d, 1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (103)(L)-2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophen ylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 3.80(s,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.50-6.52(d, 1H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (104)2-(6-methoxypyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyet hyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.80(s, 1H), 4.73-4.77(t, 1H), 6.50-6.52(d,1H), 7.29-7.30(d,2H), 7.3 8-7.39(d, 1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.72-7.74(t,1H), 7.93-7.94(d,1H); (105)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 3.80(s, 1H), 6.50-6.52(d,1H), 7.3 8-7.40(d,1H), 7.43-7.45(t, 1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (106)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m, 1H), 3.80(s,1H), 3.99-4.01(m,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); 150 (107)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.12-7. 15(d,2H), 7.22-7.24(t,2H), 7.38-7.40(d,1H), 7.43-7.45(t, 1H), 7.72-7.74(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H); (108)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.50-6.52(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d, 1H), 7.02-7.04(t,1H), 7.3 8-7.40(d, 1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (109)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s, 1H), 6.35-6.37(d, 1H), 6.50-6.52(d, 1H), 6.93(s, 1H), 7.3 8-7.40(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d, 1H), 7.72-7.74(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (11)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.3 8-7.40(d, 1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.O-13.03(d,1H); (111)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.3 8-7.40(d, 1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (112) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.80(s, 1H), 6.50-6.52(d, 1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d, 1H), 7.72-7.74(t,1H), 7.93-7.94(d, 1H); (113) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.3 8-7.40(d, 1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (114) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s,1H), 6.50-6.52(d,1H), 6.93-6.95(t, 1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (115) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 151 1 HNMR (DMSO, 400MHz) 6: 3.80(s,1H), 6.50-6.52(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (116) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 3.80(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 12(s, 1H); (117) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.3 8-7.40(d, 1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (118) 2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s,1H), 3.82(s,6H), 5.71(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (119)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s,1H), 5.98(s,1H), 6.50-6.52(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.72-7.74(t, 1H), 7.93-7.94(d,1H); (120)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.3 8-7.40(d, 1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (121)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s, 1H), 6.50-6.52(d, 1H), 6.60-6.61(d, 1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.O1(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (122)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s,1H), 5.46-5.48(d,1H), 6.50-6.52(d,1H), 7.10-7.11(d,1H), 7.38-7.40(d,1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (123)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.3 8-7.40(d, 1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H); 152 (124)2-(6-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.80(s, 1H), 6.50-6.52(d, 1H), 7.3 8-7.40(d, 1H), 7.43-7.45(t,1H), 7.72-7.74(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (125)(L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 3.17-3. 18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.32-8.35(d,1H); (126)(L)-2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 3.17-3. 18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.65-6.67(d,1H), 6.8 6(s, 1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.32-8.35(d,1H); (127)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydro xyethyl)]amide 1 HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 2.68(s,6H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t, 1H), 6.65-6.67(d,1H), 6.86(s, 1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H); (128)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.68(s,6H), 3. 1O-3.15(t,4H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H); (129)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.68(s,6H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H); (130)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 153 8.32-8.35(d,1H); (131)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.65-6.67(d,1H), 6.75-6.76(d,1H), 6.86(s,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H); (132)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.35-6.37(d, 1H), 6.65-6.67(d, 1H), 6.86(s,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H); (133)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)a mide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.O-13.03(d,1H); (134)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (135)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.68(s,6H), 2.80-2.83(m,4H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (136)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (137)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.45-8.46(d,2H); (138)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.62-6.64(t,1H), 6.65-6.67(d,1H), 6.70-6.72(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 154 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.32-8.35(d,1H); (139)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 2.68(s,6H), 6.65-6.67(d, 1H), 6.86(s, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.32-8.35(d,1H); (140)2-(4-dimnethylam-inopyridyl)-1H-benziniidazole-4-(N-2,4-dihydroxyl-5-pyrinidinyl)amlide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.30(s,1H), 8.32-8.35(d,1H), 11.53(s,1H); (141)2-(4-dimnethylam-inopyridyl)-1H-benziniidazole-4-(N-4,6-dimethoxy-2-pyriniidinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 3.82(s,6H), 5.7 1(s,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H); (142)2-(4-dimethylamiinopyiidyl)-1H-benziniidazole-4-(N-4-chloro-6-amino-2-pyriniidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 5.98(s,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H); (143)2-(4-dimethylaminopyridyl)-1H-benziniidazole-4-(N-4,6-dichloro-5-pyriniidinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 9.34(s,1H); (144)2-(4-dimethylaminopyiidyl)-1H-benziniidazole-4-(N-o-fluorophenyl)anmide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.60-6.61(d,1H), 6.63-6.64(t, 1H), 6.66-6.67(d,1H), 6.8 6(s, 1H), 6.96-6.98(t,1H), 6.99-7.O1(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H); (145)2-(4-dimethylamiinopyiidyl)-1H-benziniidazole-4-(N-2-hydroxyl-4-pyriniidiny)anmide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 5.46-5.48(d,1H), 6.65-6.67(d,1H), 6.86(s,1H), 7.1O-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H); (146)2-(4-dimethylamiinopyiidyl)-1H-benziniidazole-4-(N-6-purinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8. 18(d,1H), 8.3 2- 8.3 5(d, 1H); (147)2-(4-dimethylamiinopyiidyl)-1H-benziniidazole-4-(N-6-hydroxyl-2-purinyl)amiide 1 HNMR (DMSO, 400MHz) 6: 2.68(s,6H), 6.65-6.67(d,1H), 6.86(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.32-8.35(d,1H), 8.57-8.59(d,1H), 155 11.53(s,1H); (148)(L)-2-(2,3,4-trimethoxyphenyl)-1H-benziiidazole-44[N-(1-hydr-oxymethyl-2-p-nitrophenylh ydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 3.83(s,9H), 4.73-4.77(t, 1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8. 17-8.20(d,2H); (149)(L)-2-(2,3,4-trimethoxyphenyl)-1H-benziniidazole-4-[N-(1-hydroxymethyl-2-p-aminopheny hydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 3.83(s,9H), 4.73-4.77(t,1H), 6.27(s,2H), 6.50-6.52(d, 1H), 6.56-6.58(d,2H), 7. 11-7.12(d,2H), 7.13-7. 14(d,1H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (150)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethy 1)]amide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,9H), 4.73-4.77(t, 1H), 6.50-6.52(d,1H), 7.13-7. 14(d,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (151)2-(2,3,4-trimethoxyphenyl)-1H-benziniidazole-4-(N-N'-pipeiridinyl)aniide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (152)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m, 1H), 3.83(s,9H), 3.99-4.01(m,1H), 6.50-6.52(d,1H), 7.13-7. 14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (153)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-2'-benziniidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d,1H), 7.10-7.11(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (154)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-o-aminophenyl)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.27(s,2H), 6.38-6.40(d,1H), 6.50-6.52(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.13-7.14(d,1H), 156 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (155)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-5-benzinidazolonyl)anmide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.35-6.37(d, 1H), 6.50-6.52(d, 1H), 6.93(s,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (156)2-(2,3,4-trimethoxyphenyl)-1H-benziniidazole-4-4'-carbonamido-5'-iniidazolyl)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d, 1H), 7.13-7. 14(d, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.O-13.03(d,1H); (157)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-4'-pyrazolyl)anmide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d, 1H), 7.13-7. 14(d, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.6 1(s, 1H), 8.63-8.65(d,1H), 13.71-13.75 (d,l1H); (158)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (159)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-2-pyrazinyl)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d, 1H), 7.13-7. 14(d, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (160)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-2-pyriniidinyl)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d,1H), 6.93-6.95(t, 1H), 7. 13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (161)2-(2,3,4-trimethoxyphenyl)-1H-benziniidazole-4-(N-2-pyiidyl)anmide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.13-7. 14(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (162)2-(2,3,4-trimethoxyphenyl)-1H-benznidazole-4(N-4-methyl-5-thiazolyl)anmide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 3.83(s,9H), 6.50-6.52(d,1H), 7. 13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H); (163)2-(2,3,4-tiimethoxyphenyl)-1H-benzinidazole-4-(N-2,4-dihydroxy1-5-pyriniidinyl)anmide 157 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d, 1H), 7.13-7. 14(d, 1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (164)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4.-N4,6-dimethoxy-2-pyriniidinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 3.83(s,9H), 5.71(s,1H), 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7. 14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (165)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N4-chloro-6-amino-2-pyriniidinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 5.98(s,1H), 6.50-6.52(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (166)2-(2,3,4-tiimethoxyphenyl)-1H-benzinidazole-4-(N4,6-dichloro-5-pyriniidiny)anmide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d, 1H), 7.13-7. 14(d, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (167)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-o-fluorophenyl)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d, 1H), 6.60-6.61(d, 1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.O1(d,1H), 7.13-7.14(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (168)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-2-hydroxyl-4-pyriniidinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 5.46-5.48(d,1H), 6.50-6.52(d,1H), 7.1O-7.11(d,1H), 7.13-7. 14(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (169)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-6-puriny)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d, 1H), 7.13-7. 14(d, 1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 16-8.18(d,1H); (170)2-(2,3,4-trimethoxyphenyl)-1H-benzinidazole-4-(N-6-hydroxyl-2-purinyl)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,9H), 6.50-6.52(d,1H), 7.13-7. 14(d, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (171)(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benziniidazole-4-[N-(1-hydroxymethyl-2-p-nitroph enylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.83(s,3H), 4.73-4.77(t,1H), 5.35(s,1H), 6.88-6.90(d,1H), 7.2 1(s, 1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (172)(L)-2-(3-hydroxyl-4-methoxyphenyl)-1H-benziniidazole-4-[N-(1-hydroxymethyl-2-p-aminop henylhydroxyethyl)laniide 158 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 3.83(s,3H), 4.73-4.77(t,1H), 5.3 5(s, 1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.88-6.90(d,1H), 7.11-7.13(d,2H), 7.2 1(s, 1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (173)2-(3-hydroxyl-4-methoxyphenyl)-1H-benZinidazole-4-[N-(1-methyl-2-p-chlorophenylhydro xyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.83(s,3H), 4.73-4.77(t, 1H), 5.35(s, 1H), 6.88-6.90(d, 1H), 7.21(s, 1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (174)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzinidazole-4-(N-N'-pipeiridinyl)aiide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (175)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzinidazole-4-(N-2-piperazinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m, 1H), 3.83(s,3H), 3.99-4.01(m,1H), 5.3 5(s, 1H), 6.88-6.90(d,1H), 7.2 1(s, 1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (176)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzinidazole-4-(N-2'-benziniidazolyl)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.12-7.15(d,2H), 7.21 (s, 1H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (177)2-(3-hydroxyl-4-methoxyphenyl)-1H-benZinidazole-4-(N-o-aminophenyl)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.27(s,2H), 6.3 8-6.40(d, 1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 6.88-6.90(d,1H), 7.02-7.04(t,1H), 7.2 1(s, 1H), 7.53-7.55(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (178)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzinidazole-4-(N-5-benzinidazolonyl)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s, 1H), 6.35-6.37(d, 1H), 6.88-6.90(d,1H), 6.93(s,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.49-7.52(d,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (179)2-(3-hydroxyl4methoxyphenyl)-tH-benzimdazole4-(N4'-arbonanido-5'-inmidazolyl)anide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 159 9.24-9.26(d,1H), 13.O-13.03(d,1H); (18)2-(3-hydroxyl4-methoxyphenyl)-lH-benzimdazole-4-(N4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.6 1(s, 1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (181)2-(3-hydroxyl4-methoxyphenyl)-tH-benzimdazole4(N-(N'-piperazinyl))anide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (182)2-(3-hydroxyl4-methoxyphenyl)-tH-benzimdazole4(N-2-pyrazinyl)anide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (183)2-(3-hydroxyl4-methoxyphenyl)-tH-benzimdazole4(N-2-pyrimidinyl)anide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 6.93-6.95(t,1H), 7.2 1(s, 1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (184)2-(3-hydroxyl4-methoxyphenyl)-lH-benzimdazole4-(N-2-pyiidyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.62-6.64(t, 1H), 6.70-6.72(d,1H), 6.88-6.90(d,1H), 7.2 1(s, 1H), 7.43-7.45(t,1H), 7.51-7.52(d,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (185)2-(3-hydroxyl4-methoxyphenyl)-tH-benzimdazole4-(N4-methyl-5-hiazlyl)anide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.2 1(s, 1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s, 1H); (186)2-(3-hydoxyl4-methoxyphenyl)-lH-benzimdazode4(N-2,4-dhydroxyl-5-pyinmidinyi)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (187)2-(3-hydoxyl4methoxyphenyl)-H-benhidazd4(N4,6-dimethoxy-2-pyiidinyi)amide 1 HNMR (DMSO, 400MHz) 6: 3.79(s,6H), 3.83(s,3H), 5.35(s,1H), 5.7 1(s,1H), 6.88-6.90(d,1H), 7.2 1(s, 1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); 160 (188)2-(3-hydii344methoyheny)-lH-benAmidazoe4-(N4loro--alino-2-pyimidin)anide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 5.98(s,1H), 6.88-6.90(d,1H), 7.2 1(s, 1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (189)2-(3-hydrox34methoxyphenyi)-lH-benAmidazde-4-(N46-didlloro-5-pyiimidinyi)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (190)2-(3-hydli344methoxyphenyi)-H-benAmidaze4-(N-o-fluonphenyi)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.3 5(s, 1H), 6.60-6.61(d, 1H), 6.63-6.65(t,1H), 6.88-6.90(d,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.2 1(s, 1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (191)2-(3-hydrox34methoxyphenyi)-lH-benAmidazde-4-(N-2-hydox34pyrmidinyi)amide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 5.46-5.48(d,1H), 6.88-6.90(d,1H), 7.10-7. 11(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (192)2-(3-hydrox34methoxyphenyi)-lH-benAnidazole-4-(N-6pulrinyl)aniide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H); (193)2-(3-hydrox34methoxyphenyi)-lH-benAnidazole4-(N6hydox3-2-puiinyi)anmide 1 HNMR (DMSO, 400MHz) 6: 3.83(s,3H), 5.35(s,1H), 6.88-6.90(d,1H), 7.21(s,1H), 7.43-7.45(t,1H), 7.53-7.55(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (194)(L)-2-(2-pyiidy)-H-bewimidazoe-N-(-hydoxyiethyi-2-p-nitmphenylhydroxyedhli)lamide (refer to Figure 4) 1HMNR(DMSO0400MHz) 6:357-3.61(m, 1H), 3.6 6-3.70(m, 1 H),4.20-4.22(m, 1H),5.08 5.1 (q, 1H),5.28 -5.29(d, 1H), 6.29- 6.30O(d, 1H), 7.28-7.32(t,1H), 7.57-7.61(m, 1H), 7.67-7.73(m,4H), 8.02-8.06(m,3H), 8.57-8.59(m, 1H), 8.78-8.80(m,1H), 10.47-10.49(d, 1H), 13.62(s, 1H); (195)L)-2-(2-pidi1H-bnzidaz4[ -[1-hydrxyth34-2--pniphenylhydroxyeth4)amide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.90(d,1H), 161 7.93-7.95(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (196)2-(2-pyiidy4)-1H-benzindaze-41-meth-2-p-d1oiphenyhydoxyethy4)amide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.36-7.38(t, 1H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (197)2-(2-pyridy)-H-benzinidazole-4-(N-N'-pipelridinyt~aniide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (198)2-(2-pyiidy4)-lH-benzinidazde-4-(N-2-piperazinytWande 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H) 8.38-8.41(d,1H), 8.59-8.60(d,1H); (199)2-(2-pyiidy)-H-benzinidazole-4-(N-2'-benzinidazolyilande 1 HNMR (DMSO, 400MHz) 6: 7.12-7. 15(d,2H), 7.22-7.24(t,2H), 7.36-7.38(t, 1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (200)2-(2-pyiidy)-H-benzinidazole-4-(N-o-anliophenyilande 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (201)2-(2-pyiidy)-H-benzinidazde-4-(N-5-benzinidazolonyilande 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (202)2-(2pyiidy)-IH-benzinidazde-4-(4'-carbonamdi-5'-inidazoly4)anlkliie 1 HNMR (DMSO, 400MHz) 6: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.3 8 -8.4 1(d, 1H), 8.59-8.60(d,1H), 9.24-9.26(d,1H), 13.00-13.03(d,1H); (203)2-(2-pyiidy)-H-benziidazde4-(N4'-pyrMydl)aniide 1 HNMR (DMSO, 400MHz) 6: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.3 8 -8.4 1(d, 1H), 8.59-8.60(d,1H), 8.6 1(s, 1H), 162 8.63-8.65(d,1H), 13.71-13.75(d,1H); (204)2-(2-pyiidy)-H-benzinidazode-4-N-N'-piperazinyi))ande 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (205)2-(2-pyiidy)-H-benzinidazde-4-(N-2-pyrazinyilande 1 HNMR (DMSO, 400MHz) 6: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.3 8 -8.4 1(d, 1H), 8.43-8.45(d,1H), 8.59-8.60(d,1H); (206)2-(2-pyiidy)-lH-benzinidazole4-(N-2-pyinidinytaniide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.45-8.46(d,2H), 8.59-8.60(d,1H); (207)2(2-pyiidy)-H-benkiidazde-4-(N-2-pyiidy4)aniide 1 HNMR (DMSO, 400MHz) 6: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (208)2-(2-pyiidy)-H-benzinidazde-4-(N4medtl-5-diad34)anlke 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 12(s, 1H), 8.3 8 -8.4 1(d, 1H), 8.59-8.60(d,1H); (209)1.(2-pyiidy4)-H-eindze4N2,-hyrx45pimi3)ake 1 HNMR (DMSO, 400MHz) 6: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.3 3(s, 1H), 8.3 8 -8.4 1(d, 1H), 8.59-8.60(d,1H), 11.53(s,1H); (210)1.(2-pyiidy)-IHbniiaoe4(-,-iehx--yiii~~nd 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.7 1(s,1H), 7.36-7.38(t, 1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (211)2(2-pyiidyl)-H-ben~daoe-N4-cionanlk6o2-pynidiny4)alkle 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.3 8 -8.4 1(d, 1H), 8.59-8.60(d,1H); 163 (212)2-(2-pyiidy4)-lH-benkinidazde4-(N46-dihoro-5-pydiniin34)amkde 1 HNMR (DMSO, 400MHz) 6: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H), 9.34(s,1H); (213)2-(2-pyiidy)-lH-benkinidazde-4-(N-o-fluonmphen34aniide 1 HNMR (DMSO, 400MHz) 6: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.O1(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (214)2-(2-pyiidy)-H-benkiidazde-4-(N-2-hydrox344-pyinidiiy4)aide 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 7.1O-7.11(d,1H), 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H) 8.38-8.41(d,1H), 8.59-8.60(d,1H); (215)2-(2-pyiidy)-lH-benzinidazole-4-(N-6puriniy)anie 1 HNMR (DMSO, 400MHz) 6: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.87-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.38-8.41(d,1H), 8.59-8.60(d,1H); (216)2-(2-pyiidy)-H-benzinidazole-4-(N-6hydrox34-2-puriniiyaniide 1 HNMR (DMSO, 400MHz) 6: 7.36-7.38(t,1H), 7.43-7.45(t,1H), 7.85-7.86(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.38-8.41(d,1H), 8.57-8.59(d,1H), 8.59-8.60(d,1H), 11.53(s,1H); (217L(I)-2-(3-piid1H-bnz yidazoN-[-hydrxyth34-2--iphenylhydxyethy4)]aride 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3 .72(d,1H), 4.73-4.77(t, 1H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d, 1H), 8. 17-8.20(d,2H), 8.42-8.44(d,1H), 8.70-8.72(d,1H), 9.24(s,1H); (218XL)-2-(3-pidi1H-bnzidaz4N-[-hydrxyth34-2-- -nphenylhydroxyeth4)amide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.42-8.44(d,1H), 8.70-8.72(d, 1H), 9.24(s,1H); (219)2-(-pyiidy4)-lH-benzinidazde-4-(N-2-piperazin34aniide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.42-8.44(d,1H), 164 8.70-8.72(d,1H), 9.24(s,1H); (220)2-(-pyiidy4)-IH-benzindazole4-(N-2-pyrinuidinytanmide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.57-7.60(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.41-8.43(d,1H), 8.45-8.46(d,2H), 8.70-8.72(d,1H), 9.24(s, 1 H); (221(L)-2-(4piid1H-bnzidazo[N-[-hyd xyth34-2--ri phenylhydxyethy4)amide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3 .72(d,1H), 4.73-4.77(t, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (222XL)-2-(4piid1H-bnzidazo[N-[-hydrxyth34-2 -p iphenylhydxyeth4)amide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.25-8.28(d,2H), 8.75-8.77(d,2H); (223)2-(4-pyiidy)-H-benzinidazde4-(N-2-piperazin34aniide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.43-7.45(t,1H), 7.89-7.9 1(d, 1H), 7.93-7.94(d, 1H), 8.25-8.28(d,2H), 8.75-8.77(d,2H); (224)2-(4-pyiidy)-lH-benzinidazole4-(N-2-pyinidinytaniide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.25-8.28(d,2H), 8.45-8.46(d,2H), 8.75-8.77(d,2H); (225)1H -pyblnyi1mida~l inx 4-1hd2eh2prtphenylhydy yethnaride 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.64-7.67(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.09-8. 11(d,1H), 8.17-8.20(d,2H), 9.34-9.37(d, 1H); (226)1-b-ykaini-mnidlidnxy4-[4-ymmt-2-pmhhydnu yxydiyet]aide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H); (271(-yiaiAI-ez~aoe-N(-mty---drohnlyrxehllmd 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 165 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.61-7.63(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 9.34-9.37(d,1H); (228)2-(-pyiridaziny1-lH-benzinidazole-4-(N-N'-piperdiny4)anmide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H); (229)2-(-pyiidaziny1-H-benidazoe4-(N-2-piperaziny4)amde 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d, 1H); (230)2-(-pyiidaziny1-H-benzinidazde-4-(N-2'-benziLmiazd)anmide 1 HNMR (DMSO, 400MHz) 6: 7.12-7. 15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, 1H), 7.6 1-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 9.34-9.37(d,1H); (231)2-(-pyiidaziny1-H-benidazoe4-(Noano~pheny4)ande 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 9.34-9.37(d,1H); (232)2-(-pyiidaziny1-lH-benidaze4-(N-5-bzmiAzdbony4)amkde 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 9.34-9.37(d,1H); (233)2-(3-pyidaziny1-H-benidazde4-N4'-carbonaniido-5'-hmidazd34)anide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.1 1(d, 1H), 8.37(s,2H), 9.24-9.26(d, 1H), 9.34-9.37(d,1H), 13.00-13.03(d,1H); (234)20pyiidainy1-lH-benidazoe4-(N4-pyiitzd34)ade 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 8.6 1(s, 1H), 8.63-8.65(d,1H), 9.34-9.37(d,1H), 13.71-13.75(d,1H); (2352-(3-pyiridainy1-lH-benidaze4-N-(N'-piperziny4))aide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H) , 8.09-8.11(d,1H), 166 9.34-9.37(d,1H); (262(-yiaiAI-ezbdzl4(--yaiy*d 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.34-9.37(d,1H); (237)2-(-pyiidaziny1-H-benidazoe4-(N-2-pyimidii4)amide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 8.45-8.46(d,2H), 9.34-9.37(d,1H); (238)2-(-pyiridainy1-lH-benzinidazde4-(N-2-pyiridy4)anmide 1 HNMR (DMSO, 400MHz) 6: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8. 11-8.13(d,1H), 8.59-8.60(d,1H); (239)2-(-pyiidainy-H-benidae-N4ed14-5-diazI3)mde 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 8.12(s,1H), 9.34-9.37(d,1H); (240)20-pyiidazn1-lH-benidazN-4-dih,4-ydx34-5-pynidiny4)amde 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 8.33(s,1H), 9.34-9.37(d,1H), 11.53(s,1H); (241)2-(-pyiidaziny1-H-beniyidazde-4-(N4-dmdoxy-2-pyhidiny4)ande 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 9.34-9.37(d,1H); (242)2-(-pyiidainy-H-benzidaoe-N4~oro-a~o-2-pyinidiny4)ande 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H); (243)2-(-pyiidaziny1-H-beniyidazoe4-(N46-dichoro-5-pyfikiiny4)anmide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 9.32(s,1H), 9.34-9.37(d,1H); (244)2-(-pyiidaziny1-H-benidazde4-(N-ofluormphen34aniide 1 HNMR (DMSO, 400MHz) 6: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8.11(d,1H), 9.34-9.37(d,1H); (245)2-(-pyddaziny1-H-benidazde-4-(N-2-hydrox344py~iniidin34aniide 167 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 7.1O-7.11(d,1H), 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 9.34-9.37(d,1H); (246)2-(-pyiidaziny1-lH-benzinidazde4-(N-6pudrny4)anmide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 8.16-8. 18(d,1H), 9.34-9.37(d,1H); (247)2-(-pyiidaziny1-lH-beniyidaze4-(N--hydrox34-2-purny4)amkde 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.61-7.63(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.09-8. 11(d,1H), 8.57-8.59(d,1H), 9.34-9.37(d,1H), 11.53(s,1H); (248L- 24pyrkazi1H-bmAdn-(1i-hyNxy41-2~m-2-tnu mphenylhyiixyethiyrnde 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3 .72(d,1H), 4.73-4.77(t, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.77-7.80(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d, 1H), 8. 17-8.20(d,2H), 9.30-9.32(d,1H), 9.46(s, 1H); (249XL -- pyazn1H-b~nia ,-4 1-dnxetym -- phhynuen~yyeyrnaide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.30-9.32(d,1H), 9.46(s,1H); (250)24pyridai)1H-benmkkazde4-(N-2-piperaziny1)anide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.43-7.45(t,1H), 7.77-7.80(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.30-9.32(d,1H), 9.46(s, 1H); (251)24pyida~ny4)4H-bzmkkazde4(N-2-py ikytfaide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.77-7.80(d, 1H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 8.45-8.46(d,2H), 9.30-9.32(d,1H), 9.46(s, 1H); (22(---2prznl1-mnime-N1hdomty---imhnlyrxehllmd 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3 .72(d,1H), 4.73-4.77(t, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d, 1H), 8. 17-8.20(d,2H), 8.76-8.79(d,2H), 9.34(s, 1H); (253X)2-(2-pyiylNH-ben~inidaoI4i-1hd---mipeyhdixeit]n 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 168 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7. 11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.76-8.79(d,2H), 9.34(s, 1H); (242(-yaiy Hbni~me-N1-mhl2piwpeyyhxehl]id 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H); (252(-yaiy Hbnidz4NN-4fiiy~d 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H); (256)2-(2-pyraziny1)1H-beiidazo*e4-N-2-pipenziyt~mide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H); (257)2(2-pyray-1H-beniidaz*4N-2-bzmkkazoiide 1 HNMR (DMSO, 400MHz) 6: 7.12-7. 15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H) , 8.76-8.79(d,2H), 9.34(s,1H); (258)2-(2-pyraziny1)1H-benznidaoze-4N-o-niimpheny1)anide 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 8.76-8.79(d,2H), 9.34(s,1H); (259)2-(2-pyrainy1)1H-benzidao4eN-5-bnmazuony1)anide 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H); (260)2-(2-pyaziny1-1H-beniidad4N4-annido-5'-inizi34u)mke 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.76-8.79(d,2H), 9.24-9.26(d,1H), 9.34(s,1H), 13.00-13.03(d, 1H); (261)2-(2-pyrazinyl1H-benziidaz*e4-N4-pyrazo34)anide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 13.71-13.75(d,1H); (262)2pyin1H-beniz*44Npiperaz znyt)anide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 169 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H); (263)2-(2-pyaiylH-beniidaze4N-2-pyraziny~mide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.76-8.79(d,2H), 9.34(s,1H); (264)2-(2-pyrazinylN1H-benziidazle4-N-2-pydiymidke 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 8.76-8.79(d,2H), 9.34(s, 1H); (265)2-(2-pyraziny1)1H-benzinidazo*e4-N-2-pyri 3 4)ande 1 HNMR (DMSO, 400MHz) 6: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.76-8.79(d,2H), 9.34(s,1H); (262(-yaiy Hbnida*44nty--lzfid 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 8.76-8.79(d,2H), 9.34(s,1H); (267)2-pyl)-iHnziial-,4dhdux 3 -- yndi 3 )m 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 8.76-8.79(d,2H), 9.34(s,1H), 11.53(s,1H); (268)2-(2-pyaziny)1-ezia N6dmdix--yikiy)nd 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 8.76-8.79(d,2H), 9.34(s, 1H); (269)2-(2-pyaziny)1-eziaoeNd amn--yniiy)nd 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 8.76-8.79(d,2H), 9.34(s, 1H); (27)2-(2-pyiy1)1H-beniidaoI446idio5-pyniit4)mke 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s, 1H), 9.37(s, 1H); (271)2-(2-pyaiyl-H-benziidazol(N-o-flopheny~mide 1 HNMR (DMSO, 400MHz) 6: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s, 1H); (272)2-(2-pyaiyl-H-benziidazolN-2-hydx344pynidiny4)mke 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 170 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.76-8.79(d,2H), 9.34(s,1H); (273)2-(2-pyrazinylN1H-benziidazole4-N4purinyl~ande 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8. 18(d,1H), 8.76-8.79(d,2H), 9.34(s,1H); (274)2-(2-pyzlH-beniidaz4-Nhydx 3 4-2-puiriny)mke 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 8.76-8.79(d,2H), 9.34(s,1H), 11.53(s,1H); (Z5(L2(-ieaiy Hb~i~me-N1-ymmhl2pn~peyyrxehllmd 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 3.17-3. 18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4. 17(m,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8. 17-8.20(d,2H); (276%2(2pH-eznyidadHl41nxi~ meffian1-h kiopehyl---hroydr134h)]amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 3.17-3. 18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4. 17(m,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7. 13(d,2H), 7.43-7.45(t, 1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (272(-ieaiy Hbkk~i4[4-ehl2pdlrpeyyrxeh~md 1 HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.84-2.86(m, 1H), 3.09-3.1 1(m, 1H), 3.25-3.28(m,1H), 3.65-3.68(t, 1H), 4.14-4. 17(m, 1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (278)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-N' -piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m, 1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.84-2.86(m, 1H), 3.09-3.11(m,1H), 3.13-3. 15(m,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (279)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .93(m,4H), 2.62-2.63(m,2H), 2.65-2.66(m,2H), 2.69-2.70(m,2H), 2.72-2.74(m,2H), 2.77-2.80(m, 1H), 2.84-2.86(m, 1H), 3.02-3.05(m, 1H), 3.09-3.11(m,1H), 3.99-4.01(m,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 171 7.93-7.94(d,1H); (280)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-2' -benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (281)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 6.27(s,2H), 6.3 8-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d, 1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (282)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (283)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H); (284)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-4' -pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75 (d,l1H); (285)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 1.94-1.95(m,1H), 2.62-2.63(m,1H), 2.65-2.67(t,5H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.80-2.83(m,4H), 2.84-2.86(m, 1H), 3.09-3.11(m,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (286)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 172 8.40-8.42(d,1H); (287)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (288)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (289)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .93(m,2H), 2.45(s,3H), 1.91-1 .93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m, 1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.84-2.86(m, 1H), 3.09-3.11(m,1H), 4. 14-4.17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 12(s, 1H); (290)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (291)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.84-2.86(m,1H), 3.09-3.1 1(m,1H), 3.82(s,6H), 5.71(s,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (292)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (293)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (294)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 173 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (295)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 5.46-5.48(d,1H), 7.10-7. 11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (296)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 16-8.18(d,1H); (297)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.84-2.86(m,1H), 3.09-3. 11(m,1H), 4.14-4. 17(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (298)(L)-2-(N,N' -diethyl-2-piperazinyl)-1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p -nitrophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.02-1 .06(t,6H), 2.40-2.43(m,4H), 2.6 1-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 3. 17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.16(t,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (299)(L)-2-(N,N' -diethyl-2-piperazinyl)-1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p -aminophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.02-1 .06(t,6H), 2.40-2.43(m,4H), 2.6 1-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 3. 17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.14-4.16(t,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (300)2-(N,N'-diethyl-2-piperazinyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.02-1 .06(t,6H), 1.91-1 .93(m,2H), 2.40-2 .43(m,4H), 2.59-2.60(d,1H), 2.62-2.63(m, 1H), 2.64-2.65(t, 1H), 2.66-2.67(m,1H), 2.68-2.70(t,2H), 174 2.72-2.73(m,1H), 2.74-2.75(t, 1H), 2.76-2.78(t, 1H), 2.77-2.80(m,1H), 2.88-2.90(d, 1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 4.14-4.16(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (301)2-(N,N'-diethyl-2-piperazinyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.02-1 .06(t,6H), 2.40-2.43(m,4H), 2.6 1-2.63(d,1H), 2.65-2.67(t,1H), 2.69-2.71(t,1H), 2.72-2.74(t,1H), 2.76-2.78(t,1H), 2.88-2.90(d,1H), 4.14-4.16(t,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (302)(L)-2-(N-piperazinyl)-1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-nitrophenyl hydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.15-3.16(m,1H), 3. 18-3.22(t,4H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8. 17-8.20(d,2H); (303)(L)-2-(N-piperazinyl)-1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-aminopheny lhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.15-3.16(m,1H), 3. 18-3.22(t,4H), 3.25-3.28(m, 1H), 3.50-3.52(m, 1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7. 13(d,2H), 7.43-7.45(t, 1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (304)2-(N-piperazinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyeth ylflamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3. 17-3.22(t,4H), 3.25-3.28(m, 1H), 3.65-3.68(t, 1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (305)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.10-3. 15(t,4H), 3. 17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (306)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,3H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.78-2.82(m,5H), 3.02-3.05(m,1H), 3. 17-3.22(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); 175 (307)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (308)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.27(s,2H), 6.3 8-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d, 1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (309)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (310)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5 '-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.O-13.03(d,1H); (311)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.6 1(s, 1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (312)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-(N' -piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.95(m,2H), 2.65-2.67(t,4H), 2.78-2.80(m,4H), 2.81-2.83(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (313)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (314)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (315)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 176 7.93-7.94(d,1H), 8.07-8.09(d,1H); (316)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.45(s,3H), 2.78-2.82(m,4H), 3. 17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 12(s,1H); (317)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (318)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (319)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (320)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (321)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.O1(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (322)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 5.46-5.48(d,1H), 7.10-7. 11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (323)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 16-8.18(d,1H); (324)2-(N-piperazinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.92(m,1H), 2.78-2.82(m,4H), 3.17-3.22(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (325)(L)-2-(N-ethyl-N' -piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nit rophenylhydroxyethyl)]amide 177 HNMR (DMSO, 400MHz) 6: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.19-3.21(m,1H), 3.25-3.28(m,1H), , 3.44-3.46(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (326)(L)-2-(N-ethyl-N'-piperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-am inophenylhydroxyethyl)]amide 1 HNMR (DMSO, 400MHz) 6: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.19-3.21(m,1H), 3.25-3.28(m,1H), 3.44-3.46(t,4H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (327)2-(N-ethyl-N'-piperazinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.02-1.05(t,3H), 1.91-1.93(m,2H), 2.38-2.41(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.15-3.17(t,4H), 3.44-3.46(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (328)2-(N-ethyl-N'-piperazinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.02-1.05(t,3H), 2.38-2.41(m,2H), 3.15-3.17(t,4H), 3.44-3.46(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (329)(L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhyd roxyethyl)]amide 1 HNMR (DMSO, 400MHz) 6: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (330)(L)-2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhy droxyethyl)]amide 1 HNMR (DMSO, 400MHz) 6: 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.95-6.97(d,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (331)2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 178 4.73-4.77(t,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (332)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-N' -piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 6. 15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (333)2-(2-pyrrolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (334)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6. 18(t,1H), 6.40-6.42(d, 1H), 6.95-6.97(d, 1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (335)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6.18(t,1H), 6.27(s,2H), 6.3 8-6.39(d,1H), 6.40-6.42(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d, 1H), 6.95-6.97(d,1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (336)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6.18(t,1H), 6.35-6.37(d,1H), 6.40-6.42(d,1H), 6.93(s,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (337)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5 '-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6. 18(t,1H), 6.40-6.42(d, 1H), 6.95-6.97(d, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H); (338)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6. 18(t,1H), 6.40-6.42(d, 1H), 6.95-6.97(d, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.6 1(s, 1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (339)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-(N' -piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6. 15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 179 7.93-7.94(d,1H); (340)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6. 18(t,1H), 6.40-6.42(d, 1H), 6.95-6.97(d, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (341)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR(DMSO,400MHz)6:6. 15-6.1 8(t, 1H),6.40-6.42(d, 1H),6.93-6.95(t, 1H), 6.98-7.O1(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (342)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6. 18(t,1H), 6.40-6.42(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (343)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.15-6. 18(t,1H), 6.40-6.42(d, 1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H); (344)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR(DMSO,400MHz)6:6. 15-6.1 8(t, 1H),6.40-6.42(d, 1H),6.95-6.97(d, 1H),7.43-7.4 5(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (345)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR(DMSO,400MHz)6:3.82(s,6H), 5.71(s,1H), 6.15-6. 18(t, 1H), 6.40-6.42(d, 1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (346)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.95-6.97(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (347)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6. 18(t,1H), 6.40-6.42(d, 1H), 6.95-6.97(d, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (348)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6.18(t,1H), 6.40-6.42(d,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.90-6.93(d,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (349)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 180 1 HNMR(DMSO,400MHz)6:5.46-5 .48(d, 1H),6. 15-6.1 8(t, 1H),6.40-6.42(d, 1H),6.95-6.9 7(d, 1H),7. 10-7.1 (d, 1H),7.43-7.45(t, 1H),7.82(s, 1H),7.89-7.91l(d, 1H),7.93-7.94(d, 1H); (350)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6. 18(t,1H), 6.40-6.42(d, 1H), 6.95-6.97(d, 1H), 7.43-7.45(t,1H),7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8. 18(d,1H); (351)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.15-6. 18(t,1H), 6.40-6.42(d, 1H), 6.95-6.97(d, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (352)(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p -nitrophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 3.17-3. 18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.99(s,2H),7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d, 1H), 8. 17-8.20(d,2H); (353)(L)-2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p -aminophenylhydroxyethyl)lamide 1 HNMR(DMSO,400MHz)6: 2.45(s,3H), 3.17-3.1 8(m, 1H), 3.25-3 .28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 6.99(s,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (354)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4- [N-(1-methyl-2-p-chlorophen ylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 2.45(s,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t, 1H), 6.99(s,2H), 7.29-7.30(d,2H), 7.40-7.4 1(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (355)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-N' -piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.45(s,3H), 3.10-3.15(t,4H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (356)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .93(m,2H), 2.45(s,3H), 2.62-2.63(m, 1H), 2.65-2.66(m,1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (357)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-2' -benzimidazolyl)amide 181 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (358)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d, 1H), 6.99(s,2H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (359)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.35-6.37(d,1H), 6.93(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (360)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-4' -carbonamido-5 '-imidaz olyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.O-13.03(d,1H); (361)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-4' -pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (362)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-(N' -piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.45(s,3H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.99(s,2H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (363)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (364)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.93-6.95(t,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (365)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (366)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,6H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H); 182 (367)2-(4-rnethyl-5-arniniothiazolyl)-1H-benziniidazole-4-(N-2,4-dihydroxyl-5-pyrinidinyl)anide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (368)2-(4-rnethyl-5-aninothiazolyl)-1H-benziniidazole-4-(N-4,6-drnethoxy-2-pyrinidinyl)anide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 3.82(s,6H), 5.71(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (369)2-(4-rnethyl-5-arinothiazolyl)-H-benziniidazole4(N-4chloro-6-anino-2-pyiniidinyl)anide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 5.98(s,1H), 6.99(s,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H); (370)2-(4-rnethyl-5-arinothiazolyl)-1H-benziniidazole4-(N-4,6-dichloro-5-pyriniidinyl)anide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (371)2-(4-rnethyl-5-arinothiazolyl)-1H-benziniidazole4-(N-o-fluorophenyl)anide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.60-6.61(d,1H), 6.63-6.65(t, 1H), 6.96-6.97(t,1H), 6.99(s,2H), 7.02-7.05(d,1H), 7.43-7.45(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H); (372)2-(4-rnethyl-5-arinothiazolyl)-1H-benziniidazole4-(N-2-hydroxyl-4-pyriniidinyl)anide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 5.46-5.48(d,1H), 6.99(s,2H), 7. 1-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (373)2-(4-rnethyl-5-arinothiazolyl)-1H-benziniidazole4-(N-6-purinyl)anide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 16-8.18(d,1H); (374)2-(4-rnethyl-5-arinothiazolyl)-1H-benziniidazole4-(N-6-hydroxyl-2-purinyl)arnide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.99(s,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (375)(L)-2-(2-quinolinyl)- 1H-benzirnidazole-4- [N-(1-hydroxyrnethyl-2-p-nitrophenylhy droxyethyl)]arnide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(rn, H), 3.25-3.28(rn, H), 3.50-3.52(rn,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.64-7.65(d,2H), 7.76-7.77 (t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.OO(d,1H), 8.06-8.07(d, 1H), 8. 17-8.20(d,2H), 8.44-8.46(d,1H); (376)(L)-2-(2-quinolinyl)-1H-benzirnidazole-4- [N-(1-hydroxyrnethyl-2-p-arninophenyl 183 hydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.OO(d,1H), 8.06-8.07(d,1H), 8.40-8.41(d,1H), 8.44-8.46(d,1H); (377)2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethy 1)]amide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.35-7.37(d, 1H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d, 1H); (378)2-(2-quinolinyl)-1H-benzimidazole-4-(N-N' -piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d, 1H), 8.06-8.07(d, 1H), 8.44-8.46(d,1H); (379)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.39-7.40(d,1H), 7.43-7.45(t, 1H), 7.60-7.62(t,1H), 7.78-7.79 (t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 7.98-8.00(d, 1H), 8.06-8.07(d, 1H), 8.44-8.46(d,1H); (380)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2' -benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d, 1H), 8.44-8.46(d, 1H); (381)2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t, 1H), 7.60-7.62(t, 1H), 7.78-7.79 (t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 7.98-8.00(d,1H), 8.06-8.07(d, 1H), 8.44-8.46(d,1H); (382)2-(2-quinolinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s, 1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 184 7.93-7.94(d,1H), 7.98-8.OO(d, 1H), 8.06-8.07(d, 1H), 8.44-8.46(d,1H); (383)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t, 1H), 7.78-7.79 (t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 7.98-8.OO(d,1H), 8.06-8.07(d, 1H), 8.37(s,2H), 8.44-8.46(d, 1H), 9.24-9.26(d,1H), 13.O-13.03(d,1H); (384)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4' -pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t, 1H), 7.78-7.79 (t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 7.98-8.OO(d,1H), 8.06-8.07(d, 1H), 8.44-8.46(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (385)2-(2-quinolinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d, 1H), 8.06-8.07(d, 1H), 8.44-8.46(d,1H); (386)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t, 1H), 7.78-7.79 (t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 7.98-8.OO(d,1H), 8.06-8.07(d, 1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.44-8.46(d,1H); (387)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.OO(d,1H), 8.06-8.07(d,1H), 8.40-8.43(d, 1H), 8.45-8.46(d,2H); (388)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d, 1H), 8.04-8.05(d, 1H), 8.07-8.09(d,1H), 8.44-8.46(d,1H); (389)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.39-7.40(d,1H), 7.43-7.45(t, 1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.12(s,1H), 8.44-8.46(d,1H); (390)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t, 1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.33(s,1H), 8.44-8.46(d,1H), 11.53(s,1H); 185 (391)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.OO(d,1H), 8.06-8.07(d, 1H), 8.44-8.46(d, 1H); (392)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 7.39-7.40(d,1H), 7.43-7.45(t, 1H), 7.60-7.62(t,1H), 7.74(s,2H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.OO(d,1H), 8.06-8.07(d, 1H), 8.44-8.46(d, 1H); (393)2-(2-quinolinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t, 1H), 7.78-7.79 (t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 7.98-8.OO(d,1H), 8.06-8.07(d, 1H), 8.44-8.46(d,1H), 9.34(s,1H); (394)2-(2-quinolinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H); (395)2-(2-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 7.10-7.1 1(d,1H), 7.39-7.40(d, 1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.78-7.79 (t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d, 1H), 8.06-8.07(d, 1H), 8.44-8.46(d,1H); (396)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t, 1H), 7.78-7.79 (t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.16-8. 18(d,1H), 8.44-8.46(d,1H); (397)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.39-7.40(d,1H), 7.43-7.45(t,1H), 7.60-7.62(t, 1H), 7.78-7.79 (t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 7.98-8.00(d,1H), 8.06-8.07(d,1H), 8.44-8.46(d,1H), 11.53(s,1H); (398)(L)-2-(3-quinolinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p-nitrophenylh ydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3 .72(d,1H), 4.73-4.77(t, 1H), 7.43-7.45(t,1H), 7.59-7.60(t,1H), 7.62-7.65(d,2H), 7.77-7.79(t, 1H), 7.89-7.90(d, 1H), 7.93-7.95(d,1H), 7.98-8.00(d, 1H), 186 8.06-8.08(d,1H), 8.17-8.20(d,2H), 8.22(s,1H), 8.57(s,1H); (399)(L)-2-(3-quinolinyl)-1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.77-7.79(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 7.98-8.00(d, 1H), 8.06-8.08(d, 1H), 8.22(s, 1H), 8.57(s, 1H); (400)2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.O1(m, 1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.OO(d,1H), 8.06-8.08(d,1H), 8.22(s,1H), 8.57(s,1H); (401)2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.60-7.62(t,1H), 7.77-7.79(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 7.98-8.00(d,1H), 8.06-8.08(d,1H), 8.22(s, 1H), 8.45-8.46(d,2H), 8.57(s, 1H); (402)(L)-2-(2-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylh ydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.89-7.90(d, 1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (403)(L)-2-(2-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenyl hydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.02-4.05(m,1H), 4.73-4.77(t, 1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7. 13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (404)2-(2-piperidinyl)- 1H-benzimidazole-4- [N-(1-methyl-2-p-chlorophenylhydroxyeth ylflamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.43-1.45(m,1H), 1.47-1.48(m,1H), 187 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.02-4.05(m,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (405)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1.5 1(m,1H), 1.53-1.55(m,4H), 1.55-1.57(m,1H), 1.59-1.63(m,2H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.10-3.15(t,4H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (406)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.87-1.88(m,1H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m, 1H), 2.72-2.73(m, 1H), 2.75-2.76(m, 1H), 2.77-2.80(m, 1H), 2.82-2.85(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 4.03-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (407)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (408)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (409)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (410)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5 '-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 188 9.24-9.26(d,1H), 13.00-13.03(d,1H); (411)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (412)2-(2-piperidinyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.84-1.89(m,1H), 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 2.84-2.85(m,4H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (413)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (414)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (415)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (416)2-(2-piperidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.45(s,3H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H); (417)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.47-1.48(m,1H), 1.50-1.52(m,1H), 189 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (418)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 3.82(s,6H), 4.02-4.05(m,1H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (419)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (420)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (421)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (422)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (423)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H); (424)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 190 1 HNMR (DMSO, 400MHz) 6: 1.43-1 .45(m, 1H), 1.47-1 .48(m, 1H), 1.50-1 .52(m,1H), 1.55-1.57(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.69-2.72(m,1H), 2.79-2.81(m,1H), 4.02-4.05(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (425)(L)-2-(3-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylh ydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.71-2.73(m,1H), 2.74-7.76(m,1H), 2.78-2.80(m,1H), 2.90-2.92(t,1H), 3.12-3.15(t,1H), 3.17-3. 18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t, 1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d, 1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (426)(L)-2-(3-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenyl hydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.71-2.73(m,1H), 2.74-7.76(m,1H), 2.78-2.80(m,1H), 2.90-2.92(t,1H), 3.12-3.15(t,1H), 3.17-3. 18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t, 1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7. 13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (427)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,1H), 1.89-1 .90(m,2H), 1.92-1 .95(m, 1H), 2.62-2.36(m, 1H), 2.65-2.66(m, 1H), 2.69-2.70(m, 1H), 2.69-2.70(m,1H), 2.71-2.72(m, 1H), 2.74-7.76(m, 1H), 2.77-2.80(m, 1H), 2.82-2.84(m, 1H), 2.90-2.92(t,1H), 3.02-3.05(m,1H), 3.15-3. 17(t,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (428)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.43-1.45(m,1H), 1.53-1.55(m,1H), 1.67-1.69(m,1H), 1.92-1.95(m,1H), 2.71-2.73(m,1H), 2.74-7.76(m,1H), 2.78-2.80(m,1H), 2.90-2.92(t,1H), 3.15-3.17(t,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (429)(L)-2-(4-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylh ydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.67-1 .69(m,2H), 1.92-1 .95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3 .72(d,1H), 4.73-4.77(t, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 191 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (430)(L)-2-(4-piperidinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminopheny hydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.67-1 .69(m,2H), 1.92-1 .95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H); (431) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.67-1.69(m,2H), 1.89-1.90(m,2H), 1.92-1.95(m,2H), 2.62-2.36(m,1H), 2.65-2.66(m, 1H), 2.67-2.68(m, 1H), 2.69-2.71(m,2H), 2.72-2.74(m, 1H), 2.75-2.76(m,1H), 2.78-2.80(m, 1H), 2.82-2.83(m,2H), 3.02-3.05(m, 1H), 3.99-4.O1(m, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (432) 2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.67-1 .69(m,2H), 1.92-1 .95(m,2H), 2.69-2.71(m,2H), 2.78-2.80(m,1H), 2.82-2.83(m,2H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (433)(L)-2-(3-indolyl)- 1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.O1-7.04(t,1H), 7.3 1-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.14-8.16(d,1H), 8.17-8.20(d,2H), 8.60-8.62(d,1H); (434)(L)-2-(3-indolyl)- 1H-benzimidazole-4- [N-(1-hydroxymethyl-2-p-aminophenylhyd roxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.O1-7.04(t,1H), 7.11-7. 13(d,2H), 7.3 1-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.14-8. 16(d,1H), 8.60-8.62(d,1H); (435)2-(3-indolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.01-7.04(t,1H), 7.29-7.30(d,2H), 7.31-7.33(t,1H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8. 16(d,1H), 8.60-8.62(d,1H); 192 (436) 2-(3-indolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 7.01-7.04(t,1H), 7.3 1-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8. 16(d,1H), 8.60-8.62(d,1H); (437) 2-(3-indolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.01-7.04(t,1H), 7.3 1-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8. 16(d,1H), 8.60-8.62(d,1H); (438) 2-(3-indolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.01 -7.04(t,l1H), 7.12-7.1 5(d,2H), 7.22-7.24(t,2H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H); (439) 2-(3-indolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.06-7.08(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 14-8.16(d,1H), 8.60-8.62(d,1H); (440) 2-(3-indolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s,1H), 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.50-7.52(d,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8. 16(d,1H), 8.60-8.62(d,1H); (441)2-(3-indolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H), 8.37(s,2H), 9.24-9.26(d, 1H), 13.00- 13.03(d,1H); (442)2-(3-indolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.57-8.59(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (443)2-(3-indolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.01-7.04(t,1H), 7.3 1-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8. 16(d,1H), 8.60-8.62(d,1H); 193 (444)2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.O1-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.34-8.35(d,1H), 8.36(s, 1H), 8.40-8.42(d, 1H), 8.60-8.62(d,1H); (445)2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.O1-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8. 16(d,1H), 8.45-8.46(d,2H), 8.60-8.62(d, 1H); (446)2-(3-indolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.O1-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.57-7.58(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), , 8.14-8. 16(d,1H), 8.60-8.62(d,1H); (447)2-(3-indolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.O1-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s, 1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H); (448)2-(3-indolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.O1-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.33(s,1H), 8.60-8.62(d,1H), 11.53(s,1H); (449)2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 7.O1-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H); (450)2-(3-indolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 7.O1-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H); (451)2-(3-indolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.01-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.60-8.62(d,1H), 9.34(s,1H); (452)2-(3-indolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 194 1 HNMR (DMSO, 400MHz) 6: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.O1(d,1H), 7.02-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8. 16(d,1H), 8.60-8.62(d,1H); (453)2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 7.O1-7.04(t,1H), 7.1O-7.11(d,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8. 16(d,1H), 8.60-8.62(d,1H); (454)2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.O1-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.13-8.15(d,1H), 8.17-8.19(d,1H), 8.60-8.62(d,1H); (455)2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.O1-7.04(t,1H), 7.31-7.33(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.14-8.16(d,1H), 8.57-8.59(d,1H), 8.60-8.62(d,1H), 11.53(s,1H); (456)(L)-2-(2'-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3 .72(d,1H), 4.73-4.77(t, 1H), 7.00-7.01(d, 1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 13.O-13.03(d,1H); (457)(L)-2-(2'-imidazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 13.00-13.03(d,1H); (458)2-(2'-imidazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)la mide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H); (459)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 195 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H); (460)2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H); (461)2-(2-imidazolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.00-7.01(d,1H), 7.02-7.04(t, 1H), 7.12-7. 15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H); (462)2-(2-imidazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.05-7.08(t, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H); (463)2-(2-imidazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s, 1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H); (464)2-(2-imidazolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H), 13.05-13.07(d,1H); (465)2-(2-imidazolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.00-13.03(d,1H), 13.71-13.75(d,1H); (466)2-(2-imidazolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 13.00-13.03(d,1H); (467)2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t, 1H), 196 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 13.O-13.03(d,1H); (468)2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.OO-7.O1(d, 1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 13.O-13.03(d,1H); (469)2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.OO-7.O1(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 13.O-13.03(d,1H); (470)2-(2-imidazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.OO-7.O1(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 13.O-13.03(d,1H); (471)2-(2-imidazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.OO-7.O1(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t, 1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H), 13.O-13.03(d,1H); (472)2-(2-imidazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 7.OO-7.O1(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.O-13.03(d,1H); (473)2-(2-imidazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 7.OO-7.O1(d,1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.O-13.03(d,1H); (474)2-(2-imidazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.OO-7.O1(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H), 13.O-13.03(d,1H); (475)2-(2-imidazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.95-6.96(t,1H), 6.97-6.99(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.O-13.03(d,1H); (476)2-(2-imidazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 7.00-7.01(d,1H), 7.02-7.04(t,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 13.O-13.03(d,1H); 197 (477)2-(2-imidazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.OO-7.O1(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t, 1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 16-8.18(d,1H), 13.O-13.03(d,1H); (478)2-(2-imidazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.OO-7.O1(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H), 13.O-13.03(d,1H); (479)(L)-2-(3-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3 .72(d,1H), 4.73-4.77(t, 1H), 6.48-6.50(d, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.85-7.87(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 12.62- 12.64(d,1H); (480)(L)-2-(3-pyrazolyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.48-6.50(d, 1H), 6.56-6.58(d,2H), 7. 11-7.13(d,2H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 12.62-12.64(d,1H); (481)2-(3-pyrazolyl)-1H-benziniidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 6.48-6.50(d,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H); (482)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62- 12.64(d,1H); (483)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62- 12.64(d,1H); (484)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 198 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H); (485)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.48-6.50(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H); (486)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.48-6.50(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62- 12.64(d,1H); (487)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 12.62-12.64(d,1H), 13.O-13.03(d,1H); (488)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 12.62-12.64(d,1H), 13.71-13.75(d,1H); (489)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 12.62- 12.64(d,1H); (490)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 12.62- 12.64(d,1H); (491)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 6.93-6.95(t,1H), 7.43-7.45(t, 1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 12.62-12.64(d,1H); (492)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 12.62-12.64(d,1H); 199 (493)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 12.62-12.64(d,1H); (494)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.82(s,1H), 7.85-7.87(t,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H), 12.62-12.64(d,1H); (495)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H); (496)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 6.48-6.50(d,1H), 7.43-7.45(t, 1H), 7.74(s,2H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H); (497)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H), 12.62-12.64(d,1H); (498)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62-12.64(d,1H); (499)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 6.48-6.50(d,1H), 7.10-7.1 1(d, 1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 12.62- 12.64(d,1H); (500)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 7.43-7.45(t, 1H), 7.86-7.88(d, 1H), 7.85-7.87(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8. 18(d,1H), 12.62-12.64(d,1H); (501)2-(3-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.48-6.50(d,1H), 7.43-7.45(t,1H), 7.85-7.87(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H), 12.62-12.64(d,1H); (502)(L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 200 3.65-3.68(t,1H), 3.70-3 .72(d,1H), 4.73-4.77(t, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.67-7.70(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 9.08-9.11(d,2H); (503)(L)-2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhyd roxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.67-7.70(t,1H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 9.08-9.1 1(d,2H); (504)2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyeth ylflamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.67-7.70(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H); (505)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H); (506)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H); (507)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.12-7. 15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, 1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9. 11(d,2H); (508)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t, 1H), 7.67-7.70(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H); (509)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H); (510)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.08-9.1 1(d,2H), 9.24-9.26(d,1H), 13.00- 13.03(d, 1H); 201 (511)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.08-9. 11(d,2H), 13.71-13.75(d,1H); (512)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperaziny))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H); (513)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.08-9. 11(d,2H); (514)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t, 1H), 7.43-7.45(t, 1H), 7.67-7.70(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.08-9.11(d,2H); (515)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 9.08-9.1 1(d,2H); (516)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 12(s,1H), 9.08-9.11(d,2H); (517)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.08-9.11(d,2H), 11.53(s,1H); (518)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 7.67-7.70(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9. 11(d,2H); (519) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 9.08-9.1 1(d,2H); (520)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H), 9.34(s,1H); (521)2-(2-pyrimidinyl)-lH-benzimidazole-4-(N-o-fluorophenyl)amide 202 1 HNMR (DMSO, 400MHz) 6: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.1 1(d,2H); (522)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.08-9.11(d,2H); (523)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.86-7.88(d, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8. 18(d,1H), 9.08-9.11(d,2H); (524)2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t,1H), 7.67-7.70(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.08-9. 11(d,2H), 11.53(s,1H); (525)(L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitroph enylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 8.28-8.31(d,2H), 9.26(s,2H); (526)(L)-2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminop henylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.5 1-7.53(t,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.28-8.3 1(d,2H), 9.26(s,2H); (527)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydro xyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.38-7.39(t, 1H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H); (528)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.5 1-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H); 203 (529)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.O1(m, 1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.5 1-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H); (530)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.12-7. 15(d,2H), 7.22-7.24(t,2H), 7.38-7.41(t, 1H), 7.43-7.45(t,1H), 7.5 1-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.3 1(d,2H), 9.26(s,2H); (531)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 8.28-8.3 1(d,2H), 9.26(s,2H); (532)2-(2-phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H); (533)2-(2-phenyl-5-pyriniidinyl)-1H-benziniidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.37(s,2H), 9.24-9.26(d,1H), 9.29(s,2H) 13.00-13 .03(d, 1H); (534)2-(2-phenyl-5-pyriniidinyl)-1H-benziniidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.3 1(d,2H), 8.6 1(s, 1H), 8.63-8.65(d,1H), 9.26(s,2H), 13.71-13.75(d,1H); (535)2-(2-phenyl-5-pyriniidinyl)-1H-benziniidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.5 1-7.53(t,2H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H); (536)2-(2-phenyl-5-pyriniidinyl)-1H-benziniidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.3 1(d,2H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.26(s,2H); 204 (537)2-(2-phenyl-5-pyriniidinyl)-1H-benziniidazole-4-(N-2-pyriniidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.45-8.46(d,2H), 9.26(s,2H); (538)2-(2-phenyl-5-pyriniidinyl)-1H-benziniidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.28-8.3 1(d,2H), 9.26(s,2H); (539)2-(2-phenyl-5-pyriniidinyl)-1H-benziniidazole-4-(N-4-methyl-5-thiazolyl)amiide 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.5 1-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 12(s, 1H), 8.28-8.3 1(d,2H), 9.26(s,2H); (540)2-(2-phenyl-5-pyriniidinyl)-1H-benziniidazole-4-(N-2,4-dihydroxyl-5-pyriniidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 8.33(s,1H), 9.26(s,2H), 11.53(s,1H); (541)2-(2-phenyl-5-pyriniidinyl)-1H-benziniidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.5 1-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.3 1(d,2H), 9.26(s,2H); (542)2-(2-phenyl-5-pyrimidinyl)-1H-benziniidazole-4-(N-4-chloro-6-amino-2-pyriniidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H); (543)2-(2-phenyl-5-pyrimidinyl)-1H-benziniidazole-4-(N-4,6-dichloro-5-pyriniidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H), 9.34(s,1H); (544)2-(2-phenyl-5-pyrimidinyl)-1H-benziniidazole-4-(N-o-fluorophenyl)aniide 1 HNMR (DMSO, 400MHz) 6: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.5 1-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.3 1(d,2H), 9.26(s,2H); (545)2-(2-phenyl-5-pyrimidinyl)-1H-benziniidazole-4-(N-2-hydroxyl-4-pyriniidiny)aniide 205 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 7.1O-7.11(d,1H), 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.31(d,2H), 9.26(s,2H); (546)2-(2-phenyl-5-pyrimidinyl)-1H-benziniidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H), 8.28-8.3 1(d,2H), 9.26(s,2H); (547)2-(2-phenyl-5-pyrimidinyl)-1H-benziniidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 7.38-7.41(t,1H), 7.43-7.45(t,1H), 7.51-7.53(t,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.28-8.3 1(d,2H), 8.57-8.59(d,1H), 9.26(s,2H), 11.53(s,1H); (548)(L)-2-(4-amino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-[N-(1-hydroxymethyl-2-p-nitro phenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3 .72(d,1H), 4.73-4.77(t, 1H), 7.43-7.45(t, 1H), 7.62-7.65(d,2H), 7.74(s,2H), 7.89-7.90(d, 1H), 7.93-7.95(d,1H), 8. 17-8.20(d,2H), 8.59(s, 1H); (549)(L)-2-(4-amino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-[N-(1-hydroxymethyl-2-p-ami nophenylhydroxyethyl)laniide 1 HNMR (DMSO, 400MHz) 6: 3.17-3. 18(m, 1H), 3.25-3.28(m, 1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d, 1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7.13(d,2H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.59(s,1H); (550)2-(4-amino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-[N-(1-methyl-2-p-chlorophenylhyd roxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.4 1(d,2H), 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H); (551)2-(4-am-ino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-(N-N'-piperidinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H); (552)2-(4-amino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.99-4.01(m, 1H), 206 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H); (553)2-(4-arnino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-(N-2'-benznidazoly)anide 1 HNMR (DMSO, 400MHz) 6: 7.12-7. 15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H); (554)2-(4-arnino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-(N-o-arninophenyl)arnide 1 HNMR (DMSO, 400MHz) 6: 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t, 1H), 6.75-6.76(d,1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 8.59(s, 1H); (555)2-(4-arnino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-(N-5-benzinidazolonyl)arnide 1 HNMR (DMSO, 400MHz) 6: 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s, 1H); (556)2-(4-arnino-6-chloro-5-pyrirnidinyl)-1H-benzirnidazole-4-(N-4'-carbonanido-5 '-i rnidazolyl)arnide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 8.37(s,2H), 8.59(s, 1H), 9.24-9.26(d,1H), 13.OO-13.03(d, 1H); (557)2-(4-arnino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-(N-4'-pyrazolyl)arnide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 8.59(s,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (558)2-(4-arnino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-(N-(N'-piperazinyl))anide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(rn,1H), 2.65-2.67(t,4H), 2.80-2.83(rn,4H), 7.43-7.45(t,1H), 7.74(s,2H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s, 1H); (559)2-(4-arnino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-(N-2-pyrazinyl)arnide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 8.59(s,1H); (560)2-(4-aniio-6-chloro-5-pyriniidinyl)-1H-benziiidazole-4-(N-2-pyriniidinyl)anide 1 HNMR (DMSO, 400MHz) 6: 6.93-6.95(t, 1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 8.45-8.46(d,2H), 8.59(s, 1H); (561)2-(4-arnino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-(N-2-pyiidyl)arnide 1 HNMR (DMSO, 400MHz) 6: 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 8.59(s,1H); (562)2-(4-arnino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4(N-4-rnethyl-5-thiazolyl)arnide 207 1 HNMR (DMSO, 400MHz) 6: 2.45(s,3H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 12(s,1H), 8.59(s,1H); (563)2-(4-aniio-6-chloro-5-pyrniidinyl)-H-benziiidazole-4-N-2,4-dihydroxyl-5-pyriniidinyl)a mide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.82(s, 1H), 7.93-7.94(d, 1H), 8.33(s, 1H), 8.59(s, 1H), 11.53(s, 1H); (564)2-(4-arnino-6-chloro-5-pyriniidinyl)-1H-benziniidazole-4-(N-4,6-dirnethoxy-2-pyriniidinyl)a mide 1 HNMR (DMSO, 400MHz) 6: 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H); (565)2-(4-aniio-6-chloro-5-pyiniidinyl)-H-benziiidazole-4-N-4-chloro-6-arniino-2-pyriniidiny 1)arnide 1 HNMR (DMSO, 400MHz) 6: 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,4H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H); (566)2-(4-aino6-choro-5-pyinidiny)-1H-benhrndazole-4(N4,6-dichoro-5-pyirndiny)anide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 8.59(s,1H), 9.34(s,1H); (567)2-(4-arnino-6-chloro-5-pyrirnidinyl)-1H-benzirnidazole-4-(N-o-fluorophenyl)arnide 1 HNMR (DMSO, 400MHz) 6: 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t, 1H), 6.99-7.O1(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.5 9(s, 1H); (568)2-(4-arnino-6-chloro-5-pyrirnidinyl)-1H-benzirnidazole-4-(N-2-hydroxyl-4-pyrirnidin yl)arnide 1 HNMR (DMSO, 400MHz) 6: 5.46-5.48(d,1H), 7.1O-7.11(d,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.59(s,1H); (569)2-(4-arnino-6-chloro-5-pyrirnidinyl)-1H-benzirnidazole-4-(N-6-purinyl)arnide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, 1H), 7.74(s,2H), 7.86-7.88(d, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8. 18(d,1H), 8.59(s,1H); (570)2-(4-arnino-6-chloro-5-pyrirnidinyl)-1H-benzirnidazole-4-(N-6-hydroxyl-2-purinyl)a mide 1 HNMR (DMSO, 400MHz) 6: 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 8.62(s,1H), 11.53(s,1H); (571)(L)-2-(2-pyrrolidine-1-yl-5-pyrirnidinyl)-1H-benzirnidazole-4-[N-(1-hydroxyrnethyl-2 208 -p-nitrophenylhYdroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.92-1 .95(m,4H), 3.17-3. 18(m, 1H), 3.25-3.28(m,1H), 3.44-3.48(t,4H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H), 9.02(s,2H); (572)(L)-2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2 -p-aminophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.92-1 .95(m,4H), 3.17-3. 18(m, 1H), 3.25-3.28(m,1H), 3.44-3.48(t,4H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7. 13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d, 1H), 7.93-7.95(d,1H), 9.02(s,2H); (573)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chloroph enylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.92-1.95(m,4H), 3.25-3.28(m,1H), 3.44-3.48(t,4H), 3.65-3 .68(t,1H), 4.73-4.77(t, 1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (574)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 1.92-1 .95(m,4H), 3.1O-3.15(t,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (575)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.87-1 .89(m,2H), 1.92-1 .95(m,4H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.44-3.48(t,4H), 3.99-4.O1(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (576)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1 .95(m,4H), 3.44-3.48(t,4H), 7.12-7. 15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 9.02(s,2H); (577)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (578)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl) 209 amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1 .95(m,4H), 3.44-3.48(t,4H), 6.3 5-6.37(d, 1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (579)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imida zolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d, 1H), 13.O-13.03(d,1H); (580)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.6 1(s, 1H), 8.63-8.65(d,1H), 9.02(s,2H), 13.71-13.75(d,1H); (581)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-(N'-piperaziny))amide 1 HNMR (DMSO, 400MHz) 6: 1.87-1 .89(m,1H), 1.92-1 .95(m,4H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (582)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.02(s,2H); (583)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1 .95(m,4H), 3.44-3.48(t,4H), 6.93-6.95(t, 1H), 7.43-7.45(t,1H), 7.89-7.9 1(d, 1H), 7.93-7.94(d, 1H), 8.45-8.46(d,2H), 9.02(s,2H); (584)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H), 9.02(s,2H); (585)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzmidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 2.45(s,3H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 9.02(s,2H); (586)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidin yl)amide 210 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.02(s,2H), 11.53(s,1H); (587)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidin yl)amnide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (588)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimi dinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (589)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl) amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H), 9.34(s,1H); (590)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1 .95(m,4H), 3.44-3.48(t,4H), 6.60-6.61(d, 1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.O1(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (591)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimi dinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 5.46-5.48(d,1H), 7.1O-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (592)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 16-8.18(d,1H), 9.02(s,2H); (593)2-(2-pyrrolidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.92-1.95(m,4H), 3.44-3.48(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.02(s,2H), 11.53(s,1H); (594)(L)-2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-[N-(1-hydroxymethyl-2-p-nitr ophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 3.73-3.77(t,4H), 211 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H) , 9.02(s,2H); (595)(L)-2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-[N-(1-hydroxymethyl-2-p-am inophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m, 1H), 3.65-3.68(t, 1H), 3.70-3.72(d, 1H), 3.7 1-3.75(t,4H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7. 13(d,2H), 7.43-7.45(t, 1H), 7.89-7.90(d,1H), 7.93-7.95(d, 1H), 9.02(s,2H); (596)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-[N-(1-methyl-2-p-chlorophenylhy droxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 1.53-1.56(m,4H), 1.59-1.62(m,2H), 3.25-3.28(m,1H), 3.65-3.68(t, 1H), 3.7 1-3.75(t,4H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 9.02(s,2H); (597)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-N'-piperidiny)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1 .55(m,8H), 1.59-1 .63(m,2H), 3.10-3. 15(t,4H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (598)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m, 1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m,1H), 3.71-3.75(t,4H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (599)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-2'-benziniidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (600)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 6.27(s,2H), 6.3 8-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d, 1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (601)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-5-benziniidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); 212 (602)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4'-carbonamido-5 '-i midazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d, 1H), 13.O-13.03(d,1H); (603)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.02(s,2H), 13.71-13.75(d,1H); (604)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-(N'-piperaziny))amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (605)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-2-pyrazinyl)aniide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.02(s,2H); (606)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-2-pyriniidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.02(s,2H); (607)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d, 1H), 9.02(s,2H); (608)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1.56(m,4H), 1.59-1.62(m,2H), 2.45(s,3H), 3.71-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8. 12(s, 1H), 9.02(s,2H); (609)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyri midinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.02(s,2H), 213 11.53(s,1H); (610)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyri midinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 3.82(s,6H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (611)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-4-chloro-6-aniino-2-pyriniidin yl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (612)2-(2-piperdne-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N4,6-dichloro-5-pyrimidinyl)aniide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H), 9.34(s,1H); (613)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benziniidazole-4-(N-o-fluoropheny)aniide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.O1(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (614)2-(2-piperidne-1-yl-5-pyiniidinyl)-1H-benzimidazole-4-(N-2-hydrxyl-4-pyiniidinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 5.46-5.48(d,1H), 7.10-7. 11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (615)2-(2-piperidne-1-yl-5-pyiniidinyl)-1H-benzimiidazole-4-(N-6-puiinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8. 18(d,1H), 9.02(s,2H); (616)2-(2-piperidine-1-yl-5-pyriniidinyl)-1H-benzinmidazole-4-(N-6-hydroxyl-2-puiinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 1.53-1 .56(m,4H), 1.59-1 .62(m,2H), 3.7 1-3.75(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.02(s,2H), 11.53(s,1H); (617)XL)-2-(2-cyclopropylamino-5-pyiimidinyl)-1H-benzimdazole-4-[N-(1-hydroxyinethyl-2-p-nitr ophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 214 8. 17-8.20(d,2H), 9.02(s,2H); (618)(L)-2-(2-cyclopropylamino-5-pyrinmidinyl)-1H-benzinidazole-4[N-(1-hydroxymethyl-2-p-ami nophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: O.55-.58(m,2H), O.78-.82(m,2H), 1.35-1.37(m,1H), 3.17-3.18(m,1H), 3.25-3.28(m,1H), 3.50-3.52(m,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.73-4.77(t,1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7. 13(d,2H), 7.43-7.45(t, 1H), 7.89-7.90(d,1H), 7.93-7.95(d, 1H), 9.02(s,2H); (619)2-(2-cyclopropylamino-5-pyriniidinyl)-1H-benziniidazole-4-[N-(1-methyl-2-p-chlorophenylhy droxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: O.55-.58(m,2H), O.78-O.82(m,2H), 1.12-1.15(d,3H), 1.35-1 .37(m,1H),3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t, 1H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H), 9.02(s,2H); (620)2-(2-cyclopropylamino-5-pyrinidinyl)-1H-benziniidazole-4-(N-N'-piperidinyl)anmide 1 HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 1.52-1.55(m,4H),1.59-1.63(m,2H), 3.10-3. 15(t,4H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (621)2-(2-cyclopropylamino-5-pyrinidinyl)-1H-benziniidazole-4-(N-2-piperazinyl)amiide 1 HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 1.91-1 .93(m,2H), 2.62-2.63(m, 1H), 2.65-2.66(m, 1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.77-2.80(m,1H), 3.02-3.05(m,1H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (622)2-(2-cyclopropylamino-5-pyrinidinyl)-1H-benziniidazole-4-(N-2-benzimdazolyl)aniide 1 HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (623)2-(2-cyclopropylamino-5-pyriniidinyl)-1H-benziniidazole-4-(N-o-aniinopheny)amide 1 HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.27(s,2H), 6.3 8-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d, 1H), 7.02-7.04(t, 1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (624)2-(2-cyclopropylamino-5-pyrinidinyl)-1H-benziniidazole-4-(N-5-benzimdazolony)aniide 1 HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); 215 (625)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: O.55-O.58(m,2H), O.78-O.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 8.37(s,2H), 9.02(s,2H), 9.24-9.26(d, 1H), 13.O-13.03(d,1H); (626 2(2-cyclopropylamino-5-pyrinidinyl)-1H-benziniidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: O.55-O.58(m,2H), O.78-O.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 9.02(s,2H), 13.71-13.75 (d,l1H); (627)2-(2-cyclopropylamino-5-pyrinidinyl)1H-benzinmidazole-4-(N-(N'-piperazinyl))aniide 1 HNMR (DMSO, 400MHz) 6: O.55-.58(m,2H), O.78-.82(m,2H), 1.35-1.37(m,1H), 1.91-1.95(m,1H),2.65-2.67(t,4H), 2.80-2.83(m,4H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (628)2-(2-cyclopropylamino-5-pyrinidinyl)-1H-benziniidazole-4-(N-2-pyrazinyl)anmide 1 HNMR (DMSO, 400MHz) 6: O.55-.58(m,2H), O.78-.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H), 9.02(s,2H); (629)2-(2-cyclopropylamino-5-pyrinidinyl)-1H-benziniidazole-4-(N-2-pyrimdinyl)anmide 1 HNMR (DMSO, 400MHz) 6: O.55-.58(m,2H), O.78-.82(m,2H), 1.35-1.37(m,1H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H), 9.02(s,2H); (630)2-(2-cyclopropylamino-5-pyrinidinyl)-1H-benziniidazole-4-(N-2-pyiidyl)aniide 1 HNMR (DMSO, 400MHz) 6: O.55-O.58(m,2H), O.78-O.82(m,2H), 1.35-1.37(m,1H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d, 1H), 9.02(s,2H); (631)2-(2-cyclopropylamino-5-pyriniidinyl)-1H-benziniidazole4-(N-4methyl-5-thiazolyl)anide 1 HNMR (DMSO, 400MHz) 6: O.55-O.58(m,2H), O.78-O.82(m,2H), 1.35-1.37(m,1H), 2.45(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H), 9.02(s,2H); (632)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5 pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 0.55-0.58(m,2H), 0.78-0.82(m,2H), 1.35-1.37(m,1H), 7.43-7.45(t,1H),7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 9.02(s,2H), 11.53(s,1H); 216 (633)2-(2-cyclopropylarnino-5-pyrirnidinyl)- 1H-benzirnidazole-4-(N-4,6-dirnethoxy-2-p yrirnidinyl)arnide 1 HNMR (DMSO, 400MHz) 6: O.55-O.58(rn,2H), O.78-O.82(rn,2H), 1.35-1 .37(rn,1H), 3.82(s,6H),5.71(s, 1H), 7.43-7.45(t, 1H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 9.02(s,2H); (634)2-(2-cyclopropylarino-5-pyiinidinyl)-1H-benzinidazole-4-(N4chloro-6arino-2-pyiinidin y1~arnide 1 HNMR (DMSO, 400MHz) 6: O.55-O.58(rn,2H), O.78-O.82(rn,2H), 1.35-1 .37(rn,1H), 5.98(s, 1H), 7.43-7.45(t, 1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d, 1H), 9.02(s,2H); (652(-yorp~in--yidnl-Hbehk~i4(46clr--yhdnlaid 1 HNMR (DMSO, 400MHz) 6: O.55-O.58(rn,2H), O.78-O.82(rn,2H), 1.35-1 .37(rn,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H), 9.34(s,1H); (662(-yorp~in--yidnl-l-ehdzl4(--loohnlad 1 HNMR (DMSO, 400MHz) 6: O.55-O.58(rn,2H), O.78-O.82(rn,2H), 1.35-1 .37(rn,1H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.O1(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d, 1H), 9.02(s,2H); (637)2-(2cydopripyarnhio-5-piiidiny4)-lH-benirndazde4-(N-2-hydrox344-pyrnidin4)aniide 1 HNMR (DMSO, 400MHz) 6: 0.55-0.58(rn,2H), O.78-O.82(rn,2H), 1.35-1.37(rn,1H), 5.46-5.48(d,1H), 7.10-7. 11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.02(s,2H); (682(-yorp~in--yidny)l-ehk~i4(~urnIad 1 HNMR (DMSO, 400MHz) 6: O.55-O.58(rn,2H), O.78-O.82(rn,2H), 1.35-1 .37(rn,1H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8. 18(d,1H), 9.02(s,2H); (639)2-(2-cydopripyarnhio-5-piiidin)-H-benirndaze4-(N6hydox34-2-puiiny4)anide 1 HNMR (DMSO, 400MHz) 6: 0.55-0.58(rn,2H), 0.78-0.82(rn,2H), 1.35-1.37(rn,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 9.02(s,2H), 11 .53(s, 1H); (640)(L)-2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)- 1H-benzirnidazole-4- [N-(1-hydroxyrnet hyl-2-p-nitrophenylhydroxyethyl)larnide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.17-3.18(rn,1H), 3.25-3.28(rn,1H), 3.50-3.52(rn,1H), 3.65-3.68(t,1H), 3.70-3.72(d,1H), 3.95(s,3H), 4.73-4.77(t,1H), 7.43-7.45(t,1H), 7.62-7.65(d,2H), 7.89-7.90(d, 1H), 7.93-7.95(d, 1H), 8. 17-8.20(d,2H); (641)(L)-2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)- 1H-benzirnidazole-4- [N-(1-hydroxyrnet 217 hyl-2-p-aminophenylhydroxyethyl)lamide 1 HNMR(DMSO,400MHz)6:2.06(s,3H),3.17-3.1 8(m, 1H),3 .25-3 .28(m, 1H),3 .50-3 .52( m, 1H),3 .65-3 .68(t, 1H),3 .70-3 .72(d, 1H),3 .95(s,3H),4.73-4.77(t, 1H),6.27(s,2H),6.56-6.58(d, 2H),7. 11-7. 13(d,2H),7.43-7.45(t, 1H),7.89-7.90(d, 1H),7.93-7.95(d, 1H); (642)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4- [N-(1-methyl-2-p-chlo rophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1.15(d,3H), 2.06(s,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 3.95(s,3H), 4.73-4.77(t,1H), 7.29-7.30(d,2H), 7.40-7.4 1(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (643)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-N'-piperidiny)amide 1 HNMR (DMSO, 400MHz) 6: 1.52-1.55(m,4H), 1.59-1.63(m,2H), 2.06(s,3H), 3. 10-3.15(t,4H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (644) 2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide 1 HNMR (DMSO,400MHz)6: 1.91-1 .93(m,2H), 2.06(s,3H), 2.62-2.63(m, 1H), 2.65-2.66(m,1H), 2.69-2.70(m, 1H), 2.72-2.74(m, 1H), 2.77-2.80(m, 1H), 3.02-3.05(m, 1H), 3.95(s,3H), 3.99-4.01(m,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (645)2-(1,3-dimnethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2'-benziniidazolyl)anmide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (646)2-(1,3-dimnethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-o-aminopheny)amide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (647)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-5-benziniidazolonyl)anmide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (648)2-(1,3-dimnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-4'-carbonaniido-5'-iniidazo lyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H); (649) 2-(1,3-dimnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 218 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (650)2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-(N'-piperazinyl))anide 1 HNMR (DMSO, 400MHz) 6: 1.91-1 .95(rn,1H), 2.06(s,3H), 2.65-2.67(t,4H), 2.80-2.83(rn,4H), 3.95(s,3H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (651)2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-2-pyrazinyl)arnide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (652)2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-2-pyriniidinyl)anide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (653)2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-2-pyridyl)arnide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 6.62-6.64(t,1H), 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (654)2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-4-rnethyl-5-thiazolyl)arnide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 2.45(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.12(s,1H); (655)2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-2,4-dihydroxyl-5-pyriniidin yl)arnide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.82(s,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (656)2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-4,6-dirnethoxy-2-pyriniidin yl)arnide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.82(s,6H), 3.95(s,3H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (657)2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-4-chloro-6-arnino-2-pyrii dinyl)arnide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d, 1H), 7.93-7.94(d,1H); (658)2-(1,3-dirnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-4,6-dichloro-5-pyriniidinyl) amnide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 219 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (659)2-(1,3-dimnethyl-5-chloro-4-pyrazolyl)-1H-benziniidazole-4-(N-o-fluorophenyl)amide 1 HNMR(DMSO,400MHz)6:2.06(s,3H), 3.95(s,3H), 6.60-6.61(d, lH), 6.63-6.65(t, lH), 6.96-6.98(t,lH), 6.99-7.0l(d,lH), 7.43-7.45(t,lH), 7.89-7.91(d,lH), 7.93-7.94(d,1H); (660)2-(1,3-dimethyl-5-choro4-pyayl)-1H-benAmklazole4-(N-2-hydroxyl4-pyiiidinyi)amide 1 HNMR(DMSO,400MHz)6:2.06(s,3H), 3.95(s,3H), 5.46-5.48(d, 1H), 7.10-7.1 1(d, 1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (661)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR(DMSO,400MHz)6:2.06(s,3H), 3.95(s,3H), 7.43-7.45(t, 1H), 7.86-7.88(d, 1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8. 18(d,1H); (662)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-puri nyl)amide 1 HNMR (DMSO, 400MHz) 6: 2.06(s,3H), 3.95(s,3H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H); (663)2-(4-hydroxyphenyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (refer to Figure 5) 1 HMNR(DMSO,400MHz)6:7. 13-7. 19(m, 1H),7.23-7.27(t, 1H),7.36-7.4 1 (t, 1H),7.50-7.5 4(m,2H), 7.85-7.87(d,1H), 7.94-7.95(d,1H), 8.05-8.07(d,1H), 8.57-8.61(t,1H), 12.19-12.20(d,1H), 14.25(s,1H); (664)(L)-2-(3-hydroxyphenyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophe nylhydroxyethyl)lamide (refer to Figure 6) 1 HNMR(DMSO,400MHz)6:3.5 -3.57(m, 1H),3.64-3.72(m, 1H),4.22-4.26(m,1H),5.05 5.08(q,1H),5.25-5.27(d, 1H),6. 16-6. 18(d, 1H),6.95-6.98(d,1H), 7.23-7.27(t, 1H),7.30-7.34(t, 1H),7.36-7.40(m, 1H),7.65-7.73(m,4H),7.80-7.84(m, 1H), 8.03-8.10(m,2H), 9.76(s,1H), 10.43-10.46(d,1H), 13.3 1(s,1H); (665)2-(3-hydroxyphenyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 5.35(s,1H), 6.91-6.93(d,1H), 7.04(s,1H), 7.34-7.36(d,1H), 7.43-7.45(t,1H), 7.84-7.86(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H). Examples 666-688 1 .Og of 2,3-diaminobenzoic acid is dissolved into 20m1 of glacial acetic acid. Triethyl orthoformate (2. leq.) is added into the above mixture at temperature of 0 0 C; and to 220 stir it for 2 hours at temperature of 0 ~5 C; and 150ml of water is added into it, and then to isolate and filter to produce 2-ethoxy-1H-benzimidzzole-4-formic acid. The yield is about 89%. 2-ethoxy-1H-benzimidzzole-4-fonnic acid is added into 15ml of thionyl chloride, and to react for 60 minutes, and after end ofthe reaction completely, and (L)-2-amino-1-p-nitrophenyl-1,3-propylene glycol (1.leq) is added into the reaction mixture under stirring for 2 hours at the room temperature, and then to filter the inorganic salt, and evaporate the solvent to dry, to obtain the final product of (L)-2-ethoxy-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)ami de. The yield is about 91%. Using the same process to prepare the compounds in Table 3. 0 N N Table 3 Field No. Compounds X Y (L)-2-ethoxy-1H-benzimidazole-4-[N 02NH H OH 666 -(1-hydroxymethyl-2-p-nitrophenylhy CH 3 H HO NH H droxyethyl)]amide HO H (L)-2-ethoxy-1H-benzimidazole-4-[N HH OH H OH 667 -(1-hydroxymethyl-2-p-aminophenyl CH 3 H H NH H hydroxyethyl)]amide HO H 2-ethoxy-1H-benzimidazole-4-[N-(1- H H 668 methyl-2-p-chlorophenylhydroxyethy CH3 NH CH3 92 1)]amide HO H 2-ethoxy-1H-benzimidazole-4-(N- N /N 669 CH392 N'-piperidinyl)amide H HN N 670 2-ethoxy-1H-benzimidazole-4-(N- o93 2-piperazinyl))amide N H 2-ethoxy-1H-benzimidazole-4-(N- o N94 671 2'-benzimidazolyl)amide
N
221 H 672 2-ethoxy-1H-benzimidazole-4-(N- o89 o-aminophenyl)amide NH 2 NH 673 2-ethoxy-1H-benzimidazole-4-(N- > 91 5-benzimidazolonyl)amide N N H H 2-ethoxy- 1H-benzimidazole-4-(N- / N 674 4'-carbonamido-5'-imidazolyl)ami
CH
2 N N86 H de H N N 675 2-ethoxy- 1H-benzimidazole-4-(N- 93 4' -pyrazolyl)amide NH 676 2-ethoxy- 1H-benzimidazole-4-(N- H 91 (N'-piperazinyl))amide N-N\-JNH 677 2-ethoxy-1H-benzimidazole-4-(N- I CH31N 92 2-pyrazinyl)amide NN H 678 2-ethoxy-1H-benzimidazole-4-(N- 92 2-pyrimidinyl)amide N N 2-ethoxy- 1H-benzimidazole-4-(N- 93 2-pyridyl)amide N"0
CH
3 2-ethoxy-1H-benzimidazole-4-(N- N 4-methyl-5-thiazolyl)amide N 2-ethoxy- 1H-benzimidazole-4-(N- N H -- o HO5 681 2,4-dihydroxyl-5-pyrimidinyl)ami CH3N\ 85 OH de 2-ethoxy- 1H-benzimidazole-4-(N- N OCH3 682 4,6-dimethoxy-2-pyrimidinyl)amid \CH / 94 e OCH3 CI 2-ethoxy-1H-benzimidazole-4-(N- N 683 4-chloro-6-amino-2-pyrimidinyl)a C>H / 89 mide NH 2 222 cI 684 2-ethoxy- 1 H-benzimidazole-4-(N- K\/- 0 4,6-dichloro-5 -pyrimidinyl)amide N NH 65 2-ethoxy- 1 H-benzimidazole-4-(N- -- O- CN 87 2-hydroxyl-4-pyrimidinyl)amide 687 2-ethoxy- 1 H-benzimidazole-4-(N- -- O- CN N 93 6-purinyl)amide N N H OH 68 2-ethoxy- 1H-benzimidzzole-4-(N- -NO- H N N 8 6-hydroxyl-2-purinyl)amide -N N N HH Structure Identification of Products (666)(L)-2-ethoxy-1H-benziniidazole-4-[N-(1-hydroxyinethyl-2-p-nitrophenylhydroxyethyl)laniide 1 HNMR (DMSO, 400MHz) 6: 1.32-1 .35(t,3H), 3.17-3. 18(m, 1H), 3.25-3 .28(m,1H), 3.50-3.52(m,1H),3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.29-4.33(m,2H), 4.73-4.77(t, 1H), 7.43-7.45(t,1H),7.62-7.65(d,2H), 7.89-7.90(d,1H), 7.93-7.95(d,1H), 8.17-8.20(d,2H); (667)XL)-2-ethoxy-1H-benAmidazole4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.32-1 .35(t,3H), 3.17-3. 18(m, 1H), 3.25-3 .28(m,1H), 3.50-3.52(m,1H),3.65-3.68(t,1H), 3.70-3.72(d,1H), 4.29-4.33(m,2H), 4.73-4.77(t, 1H), 6.27(s,2H), 6.56-6.58(d,2H), 7.11-7. 13(d,2H), 7.43-7.45(t,1H), 7.89-7.90(d, 1H), 7.93-7.95(d,1H); (668)2-ethoxy-1H-benmidazole-N-(1-methyl-2-p-chlorophenylhydroxyethyl)lamide 1 HNMR (DMSO, 400MHz) 6: 1.12-1. 15(d,3H), 1.32-1 .35(t,3H), 3.25-3.28(m,1H), 3.65-3.68(t,1H), 4.29-4.33(m,2H), 4.73-4.77(t, 1H), 7.29-7.30(d,2H), 7.40-7.41(d,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (669)2-ethoxy-1H-benzimidazole-4-(N-N'-piperidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1 .35(t,3H), 1.52-1 .55(m,4H), 1.59-1 .63(m,2H), 223 3.10-3.15(t,4H),4.29-4.33(m,2H),7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (670)2-ethoxy-1H-benAmidazole-4-(N-2-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 1.91-1.93(m,2H), 2.62-2.63(m,1H), 2.65-2.66(m,1H), 2.69-2.70(m,1H), 2.72-2.74(m,1H), 2.77-2.80(m,1H), 3.02-3.05(m, 1H), 3.99-4.01(m,1H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (671)2-ethoxy-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.12-7.15(d,2H), 7.22-7.24(t,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (672)2-ethoxy-1H-benzimidazole-4-(N-o-aminophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.27(s,2H), 6.38-6.40(d,1H), 6.56-6.58(t,1H), 6.75-6.76(d,1H), 7.02-7.04(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (673)2-ethoxy-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.35-6.37(d,1H), 6.93(s,1H), 7.43-7.45(t,1H), 7.54-7.56(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (674)2-ethoxy-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.37(s,2H), 9.24-9.26(d,1H), 13.00-13.03(d,1H); (675)2-ethoxy-1H-benzimidazole-4-(N-4'-pyrazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.61(s,1H), 8.63-8.65(d,1H), 13.71-13.75(d,1H); (676)2-ethoxy-1H-benzimidazole-4-(N-(N'-piperazinyl))amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 1.91-1.95(m,1H), 2.65-2.67(t,4H), 2.80-2.83(m,4H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.90-7.91(d,1H), 7.93-7.94(d,1H); (677)2-ethoxy-1H-benzimidazole-4-(N-2-pyrazinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.34-8.35(d,1H), 8.36(s,1H), 8.40-8.42(d,1H); (678)2-ethoxy-1H-benzimidazole-4-(N-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.93-6.95(t,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.45-8.46(d,2H); (679)2-ethoxy-1H-benzimidazole-4-(N-2-pyridyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.62-6.64(t,1H), 224 6.70-6.72(d,1H), 7.43-7.45(t,1H), 7.55-7.57(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.07-8.09(d,1H); (680)2-ethoxy-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 2.45(s,3H), 4.29-4.33(m,2H), 7.43-7.45(t,lH), 7.89-7.91(d,lH), 7.93-7.94(d,lH), 8.12(s,lH); (681)2-ethoxy-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,lH), 7.82(s,lH), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.33(s,1H), 11.53(s,1H); (682)2-ethoxy-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 3.82(s,6H), 4.29-4.33(m,2H), 5.71(s,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (683)2-ethoxy-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 5.98(s,1H), 7.43-7.45(t,1H), 7.74(s,2H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (684)2-ethoxy-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 9.34(s,1H); (685)2-ethoxy-1H-benzimidazole-4-(N-o-fluorophenyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 6.60-6.61(d,1H), 6.63-6.65(t,1H), 6.96-6.98(t,1H), 6.99-7.01(d,1H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (686)2-ethoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 5.46-5.48(d,1H), 7.10-7.11(d,1H), 7.43-7.45(t,1H), 7.82(s,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H); (687)2-ethoxy-1H-benzimidazole-4-(N-6-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.86-7.88(d,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.16-8.18(d,1H); (688)2-ethoxy-1H-benzimidzzole-4-(N-6-hydroxyl-2-purinyl)amide 1 HNMR (DMSO, 400MHz) 6: 1.32-1.35(t,3H), 4.29-4.33(m,2H), 7.43-7.45(t,1H), 7.89-7.91(d,1H), 7.93-7.94(d,1H), 8.57-8.59(d,1H), 11.53(s,1H)o Meatures of Properties: 225 1. Meatures of anti-coxsackie B3 viruses activity of the compounds The products are applied for meatures of antivirus properties of Vero cells. Refer to the results of Table 3: datum of anti -coxsackie B3 viruses activities of some compounds. Table 3 NAME OF COMPOUNDS X Y ICso(pg/ml) (L)-2-(2-pyridyl)-1H-benzimidazole- 0 2N H N-s H H 4-[N-(1-hydroxymethyl-2-p-nitrophe -( H H 1.76 H nylhydroxyethyl)]amide H O CI 2-(2-pyridyl)-1H-benzimidazole-4-[ OH H H N-(1-methyl-2-p-chlorophenylhydro -4 H 4.115 xyethyl)]amide H 2-(3-pyridyl)-1H-benzimidazole-4-[ C' H H N-(1-methyl-2-p-chlorophenylhydro - OH H 2.37 H xyethyl)]amide H 0 2 N (L)-2-(2-thienyl)-1H-benzimidazole- H H 4-[N-(1-hydroxymethyl-2-p-nitrophe H H 15.90 nylhydroxyethyl)]amide H HOH CI 0I0 2-(2-thienyl)- 1H-benzimidazole-4-[ HH N-(1-methyl-2-p-chlorophenylhydro OHH 5.30 xyethyl)]amide H H
O
2 N (L)-2-(5-nitro-2-thienyl)-1H-benzimi H dazole-4-[N-(1-hydroxymethyl-2-p- / NH H 0.69 nitrophenylhydroxyethyl)]amide H HOH CI 2-(5-nitro-2-thienyl)- 1H-benzimidaz H H OH ole-4-(N-(1-methyl-2-p-chloropheny / H 7.12 lhydroxyethyl))-amide H
H
226 2-thienyl- 1 H-benzimidazole-4-(N 1.0 -(2-fluorophenyl)-amide // \10 2-(5-nitro-2-thienyl)- 1H-benziniidaz NC/ >9.25 ole-4-(N-(2-fluorophenyl))-amide Ix / (L)-2-(5 -amino-2-thienyl)-l1H-ben
NH
2 02N H zimidazole-4-[N-(l1-hydroxymeth H H yl-2-p-nitrophenylhydroxyethyl)] H 2.3 amide H HO 2-(5 -amino-2-thienyl)- 1 H-benzim H idazole-4-(N-o-fluorophenyl) amid o/ \3.5 e
NH
2 CH 3 2-(5 -amino-2-thienyl)- 1H-benzimi 8.7 dazole-4-(N-o-methylphenyl)amide 2-(5 -amino-2-thienyl)- 1 H-benzim LH idazole-4-(N-p-hydroxyphenyl)a N6.5 mide / OH NF 2-(4-methoxypyridyl)- 1H-benzim idazole-4-(N-o-fluorophenyl) amid /\10.2 eOCH 3 __ (L)-2-(4-methoxypyridyl)- 1H-ben PNN HH H zimidazole-4-[N-(l1-hydroxymeth H HH6. yl-2-p-nitrophenylhydroxyethyl)] amide OC 3 H HO N O 2-(4-methoxypyridyl)- 1H-benzim O idazole-4-(N-o-hydroxyphenyl)a 16.2 mide ICH N 2-(4-methoxypyridyl)- 1H-benzim idazole-4-(N-p-aminophenyl)ami 13.4 de
OC-
3 NH 2 227 (L)-2-(6-methoxypyridyl)- 1H-ben N C3 02NH zimidazole-4-[N-(l1-hydroxymeth H H' Ht 11H2 yl-2-p-nitrophenylhydroxyethyl)] K)' H 1. amide H 2-(6-methoxypyridyl)- 1H-benzim N OCH 3 F idazole-4-(N-o-fluorophenyl) amid r~(14.1 2-(6-methoxypyridyl)- 1H-benzim N OCH 3 OH idazole-4-(N-o-hydroxyphenyl)a r~(15.7 mide ' Y 2-(6-methoxypyridyl)- 1H-benzim N OCH 3 idazole-4-(N-p-aminophenyl)ami 16.8 de (' ,NH 2 (L)-2-(4-dimethylaminopyridyl)- 1 N 02N H H-benzimidazole-4-[N-(l1-hydrox H H ymethyl-2-p-nitrophenylhydroxye
-
H1. thyl)] amide HOC 3 ) H 2-(4-dimethylaminopyridyl)- 1H-b N F enzimidazole-4-(N-o-fluoropheny Q 1 ,II ib 9.6 1)amide N (C H 3 ) 2-(4-dimethylaminopyridyl)- 1H-b N OH enzimidazole-4-(N-o-hydroxyphe K)9.8 nyl)amide N(CH 3
)
2 2-(4-dimethylaminopyridyl)- 1H-b N enzimidazole-4-(N-p-aminopheny P-l10.2 1)amide N(C H 3
)
2
NH
2 (L)-2-(3-pyridazinyl)- 1H-benzimi 02NH dazole-4-[N-(1-hydroxymethyl-2- N ,H H p-nitrophenylhydroxyethyl)] amidH5. e HO H 2-(3-pyridazinyl)- 1H-benzimidaz No 12.3 ole-4-(N-o-fluorophenyl)amide -t > 2. OH 2-(3-pyridazinyl)- 1H-benzimidaz No', 15.2 ole-4-(N-o-hydroxyphenyl)amide
L-)
228 2-(3-pyridazinyl)- 1H-benzimidaz No' 10.2 ole-4-(N-p-aminophenyl)amide
NH
2 (L)-2-(2-N-methyl-4-N-methylpip C2N erazinyl)- 1H-benzimidazole-4-[N ( H H -(1-hydroxymethyl-2-p-nitrophen KNH H 9.2 ylhydroxyethyl)]amide
CH
3 HO H 2-(2-N-methyl-4-N-methylpiperaz H F inyl)- 1H-benzimidazole-4-(N-o-fl /N\ 8.9 uorophenyl)amide C H 3 2-(5-methy-2-thienyl)- 1H-benzim CH 3 OH idazole-4-(N-o-hydroxyphenyl)a 18.5 mide
CH
3 2-(2-N-methyl-4-N-methylpiperaz N inyl)- 1H-benzimidazole-4-(N-p-a 3.5 minophenyl)amide H NH 2 0 2 N (L)-2-(2-pyrazinyl)- 1H-benzimida N H zole-4-[N-(1-hydroxymethyl-2-p- N H HH 2.3 nitrophenylhydroxyethyl)] amide H H HO F N 2-(2-pyrazinyl)- 1H-benzimidazol -6.5 e-4-(N-o-fluorophenyl)amide CN ) 6b OH N 2-(2-pyrazinyl)- 1H-benzimidazol
-
3.5 e-4-(N-o-hydroxyphenyl)amide C ) N 2-(2-pyrazinyl)- 1H-benzimidazol 4 e-4-(N-p-aminophenyl)amide CN 4.
NH
2 o 2 N (L)-2-N-piperazinyl- 1H-benzimid N H azole-4-[N-(1-hydroxymethyl-2-o N H H 4.2 -nitrophenylhydroxyethyl)] amide NOH HO 2-N-piperazinyl- 1H-benzimidazol N 4.8 e-4-(N-o-fluorophenyl)amide N> 229 N 2-N-piperazinyl- 1H-benzimidazol ( 1 6.3 e-4-(N-p-aminophenyl)amide N>
NH
2 (L)-2-(4-methyl-5-aminothiazolyl 02N H \aI H )-1H-benzimidazole-4-[N-(1-hydr S H H oxymethyl-2-p-nitrophenylhydrox CH3 H 8.9
NH
2 yethyl)]amide HO H 2-(4-methyl-5-aminothiazolyl)- 1 N S F H-benzimidazole-4-(N-o-fluoroph CH3/( 10.2 enyl)amide NH2 2-(4-methyl-5-aminothiazolyl)- 1 N S H-benzimidazole-4-(N-p-aminoph CHX< 9.8 enyl)amide
NH
2
NH
2 0 2 N (L)-2-thiazolyl- 1H-benzimidazole NH H H -4-[N-(1-hydroxymethyl-2-p-nitro s H H 11.2 phenylhydroxyethyl)]amide H HOH 5-thiazolyl- 1H-benzimidazole-4-( N-p-aminophenyl)amide
NH
2 (L)-2-(3,4,5-trihydroxyphenyl)-1 OH 2N H H-benzimidazole-4-[N-(1-hydrox OH OH H H ymethyl-2-p-nitrophenylhydroxye H 10.2 thyl)]amide HO H 2-(2,3,4-trihydroxyphenyl)- 1H-be OH nzimidazole-4-(N-p-hydroxyphen OH OH11.2 yl)amide OH (L)-2-(2-pyrimidinyl)- 1H-benzimi 02N dazole-4-[N-(1-hydroxymethyl-2- N N H H p-nitrophenylhydroxyethyl)]amid H 9.8 eHO H 2-(2-pyrimidinyl)- 1H-benzimidaz N N ole-4-(N-o-fluorophenyl)amide \8.8 OH 2-(2-pyrimidinyl)- 1H-benzimidaz N7.8 ole-4-(N-o-hydroxyphenyl)amide 7.8 230 2-(2-pyrimidinyl)- 1H-benzimidaz NIO'.'N 9.8 ole-4-(N-p-aminophenyl)amide K .
NH
2 (L)-2-(2-phenyl-5 -pyrimidinyl)- 1 02N H H-benzimidazole-4-[N-(l1-hydrox yjH H ymethyl-2-p-nitrophenylhydroxye N -N H1. thyl)] amide HO H 2-(2-phenyl-5-pyrimidinyl)- 1H-beF nzimidazole-4-(N-o-fluorophenyl) NS N12.6 amide J 2-(2-phenyl-5-pyrimidinyl)- 1H-be [~1OH nzimidazole-4-(N-o-hydroxyphen -13.2 N' N yl)amide 2-(2-phenyl-5-pyrimidinyl)- 1H-be nzimidazole-4-(N-p-aminophenyl NS N15.2 )amide NH 2 (L)-2-(4-amino-6-chloro-5-pyrimi cl N H2 dinyl)- 1H-benzimidazole-4-[N-(1 l H H -hydroxymethyl-2-p-nitrophenylh H77. ydroxyethyl)] amide HHO H 2-(4-amino-6-chloro-5-pyrimidin cl F yl)-l H-benzimidazole-4-(N-o-flu N11.3 orophenyl)amide NH 2 __ 2-(4-amino-6-chloro-5 -pyrimidin cl N OH yl)-l H-benzimidazole-4-(N-o-hyd N 12.3 roxyphenyl)amide NH 2 2-(4-amino-6-chloro-5-pyrimidin cl N') yl)-l H-benzimidazole-4-(N-p-ami N 14.1 nophenyl)amide NH 2
NH
2 (L)-2-(2-pyrrolyl)- 1H-benzimidaz 2H H ole-4- [N-(l1-hydroxymethyl-2-p-n CH.H5.3 itrophenylhydroxyethyl)] amideH 2-(2-pyrrolyl)- 1H-benzimidazole- O N / \9.2 4-(N-o-fluorophenyl)amide 231 (L)-2-(3,5-dimethyl-2-pyrrolyl)- 1 C 02N H H-benzimidazole-4-[N-(1-hydrox N H H H 8.6 ymethyl-2-p-nitrophenylhydroxye CHH thyl)]amide HO H 2-(3,5-dimethyl-2-pyrrolyl)- 1H-b CH 3 N OH enzimidazole-4-(N-o-hydroxyphe 10.2 nyl)amide CH3 (L)-2-(N-methyl-2-pyrrolyl)- 1 H-b O2N enzimidazole-4-[N-(1-hydroxyme O N-CH 3 H H H H thyl-2-p-nitrophenylhydroxyethyl )]amide HO H 2-(N-methyl-2-pyrrolyl)- 1H-benzi midazole-4-(N-o-fluorophenyl)am ,N-CH 3 13.2 ide L_ (L)-2-(2-piperidinyl)- 1 H-benzimi oN dazole-4-[N-(1-hydroxymethyl-2- H H p-nitrophenylhydroxyethyl)] amid .H* e HO H 2-(2-quinolinyl)- 1H-benzimidazol F15.3 e-4-(N-o-fluorophenyl)amide N-K. / \5 NH 2-(3-indolyl)- 1H-benzimidazole-4 10.8 -(N-p-aminophenyl)amide
NH
2 02~N NHH (L-)2-(3-indolyl)- 1H-benzimidazo NHONH H le-4-[N-(1-hydroxymethyl-2-p-nit H H 9.6 rophenylhydroxyethyl)]amide H HO0 RBV - 353.55 In the above table: "-" indicates that these samples don' t have anti-coxsackie B3 viruses activities at the maximum nontoxic dose.
IC
5 0 indicates half inhibitary concentration for viruses. RBV indicates triazole nucleoside, is also called ribavirin, virazole. It may be seen from the result of test, these compounds have better properties of anti-coxsackie B3 viruses. These compounds of the present invention have better effects on the coxsackie viruses of the picornaviridae and can inhibit coxsackie viruses.
232 Although the present invention has been described in connection with the above embodiments, it should be understood that the present invention is not limited to such preferred embodiments and procedures set forth above. The embodiments and procedures were chosen and described in order to best explain the principles of the invention and its practical application, to thereby enable others skilled in the art to best utilize the invention. It will be apparent to those skilled in the art that various substitution, modifications and changes may be thereto without departing from the scope and spirit of the invention. Therefore, the intention is intended to cover all alternative constructions and equivalents falling within the spirit and scope of the invention as defined only by the appended claims and equivalents thereto. Throughout this specification and the claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps. The reference in this specification to any prior publication (or information derived from it), or to any matter which is known, is not, and should not be taken as an acknowledgment or admission or any form of suggestion that that prior publication (or information derived from it) or known matter forms part of the common general knowledge in the field of endeavour to which this specification relates.
Claims (13)
1. The benzimidazole-4-carboxamide derivatives of Formula (I) or pharmaceutically acceptable salts thereof, Y N-H 0 N (I) wherein, X represents monosubstituted or bissubstituted or polysubstitued C 1 -C 1 4 alkoxy, monosubstituted or bisubstituted or polysubstitued C 1 -C 1 4 alkyl, monosubstituted or bisubstituted or polysubstitued C 2 -C 1 4 alkenyl, monosubstituted or bisubstituted or polysubstitued C 6 -C 1 4 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom; Y represents hydrogen, monosubstituted or bisubstituted or polysubstitued C 1 -C 16 alkyl, monosubstituted or bisubstituted or polysubstitued C 6 -C 12 aryl, or monosubstituted or bisubstituted or polysubstitued 5 to 6 membered heterocyclic group, or monosubstituted or bisubstituted or polysubstitued fused ring group containing nitrogen heteroatom; wherein, X is selected from one of the following groups: F.9 RIO R 17 R 1 - 3 N n -R,' R 1 R Ris -O-R R 2 R 4 R 3 '-C=C- R, R 12 R Ri 9 R'17 NR"17R iNR ' 2 4 - R29 Ri / N R23N R 2 3 N N N R' 2 0 R" 2 0 RR 5 R 3 1 30 R3 R 38 N R43 R39 P 5 R 45 R R35 N R 4 R' 234 pM 1 R'mi 1x 1 NN___- N_ 1 N Rm 2 R / Rk 2 Rk 3 Rk 2 Rk 3 N Rk 1 N 1(4 Rk 4 Rpi Rm2 R'm 1 1 N Rp 2 NN) Rk5 Rki N Rk5 Rm3 Rk 6 Rk 6 Rp 4 Rp 3 Ry 1 NH Rmz Rbzp..N- N Ry \ / Rz N Rbz Ry 3 Ry 4 Rmzi or Rbz 3 Rwyi Rwy 3 I I - C)n-C- Rwy 5 I I wherein, R is selected from -H, or RWY 2 Rwy 4 , wherein, n=0-5, Rwyi, Rwy2, Rwy 3 , Rwy 4 and Rwy 5 are respectively and independently selected from -H, -CH 3 , or -CH 2 CH 3 ; n=0-5; R 1 , R 2 , R 3 , R 4 and R 5 are respectively and independently selected from -H, -CH 3 , -F, -Cl, -Br, -I, -OH, -OCH 3 , -OCH 2 CH 3 , -NO 2 , -NH-CH 3 , -NH-CH 2 CH 3 , -NH-CH 2 CH 2 OH, C HH-N-CH C CH-1N -CHC H 3 , C H-N -C H 2 C H 2 O H C H -C H2-N -C H C H, CH 3 CH-N-CHCH 2 OH OHCH CH>N-CH CH 2 OH or phenyl substituted by one or several substituents Ra, Ra is selected from -F, -Cl, -Br, -I, -CH 3 , -CH 2 CH 3 , -OH, -OCH 3 , -OCH 2 CH 3 , -CH 2 CH 2 OH, -NO 2 , -NH 2 , -N(CH 3 )2, -N(CH 2 CH 3 )2, -N(CH 2 CH 2 OH )2, -CN, -COOH, -COOCH 3 , -COOCH 2 CH 3 , or -COOC 6 H 5 ; R 1 ', R2' and R 3 ' are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , CR1" C -(CH 2 )n or R , wherein n is an integer between 0 and 5; R 1 " and R 2 " are respectively and independently selected from -H, -CH 3 , or -CH 2 CH 3 ; R 9 , Rio, R 1 1 , R 12 and R 13 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -COOH , -COOCH 3 , -COOCH 2 CH 3 , -OH, -OCH 3 , -OCH 2 CH 3 , -CN, -F, -Cl, 235 -Br, -I, or -NH 2 , -N(CH 3 ) 2 , or -N(CH 2 CH 3 ) 2 ; R 1 7 , Ri 8 , R 19 , R 20 , R'17, R'18, R'19, R' 20 , R"17, R"is, R"19 and R" 20 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OH, -OCH 3 , -OCH 2 CH 3 , -CF 3 , -CCl 3 , -CBr 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , -NO or -NO 2 , which cannot represent H simultaneously; R 23 , R 24 , R 25 , R' 23 , R' 24 and R' 25 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -F, -Cl, -Br, -I, -OH, -OCH 3 , -OCH 2 CH 3 , -NO 2 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , -COOH, -COOCH 3 , or -COOCH 2 CH 3 ; R 29 , R 3 M and R 31 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, or -N(CH 2 CH 2 OH) 2 ; R 34 , R 3 6 and R41 are respectively and independently selected from -H, -(CH 2 )n 1 CH 3 , -CH 2 OH, -CH 2 CH 2 OH, -CH(CH 3 ) 2 or -CH 2 CH(OH)CH 3 , n is an integer between 0 and 5; R 35 , R 37 , R 38 , R 39 , R 4 o, R 4 2 and R 43 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, or -N(CH 2 CH 2 OH) 2 ; Z is selected from N, 0 or S. R44, R 45 , R 46 , R'44, R' 45 and R' 46 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OH, -OCH 3 , -OCH 2 CH 3 , -NO 2 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , -CN or -COOH, -COOCH 3 , or -COOCH 2 CH 3 ; Rsi, Rs 2 , R si and R s2 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , -F, -Cl, -Br, -I, or NHCOCH 3 , NHCOCH 2 CH 3 , or NHCOC 6 H 5 ; Rmi, Rm2, Rm3, R mi, R m2 and R m3 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -F, -Cl, -Br, -I, -OH, -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , , NH Rm"-N N or -NHC 6 H 5 ; Rkl, Rk2, Rk3, Rk4, Rk5 and Rk6 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, or -N(CH 2 CH 2 OH) 2 ; 236 Rei, Rp 2 , RP 3 and Rp 4 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, or -N(CH 2 CH 2 OH) 2 ; Ryi, Ry 2 , Ry 3 and Ry 4 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, or -N(CH 2 CH 2 OH) 2 ; Rmzl is selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 OH, -C 6 H 5 , or -CH 2 C 6 H 5 ; Rmz2 and Rmz3 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, or -N(CH 2 CH 2 OH) 2 ; Rbzl is selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 OH, -C 6 H 5 , or -CH 2 C 6 H 5 ; Rbz2 and Rbz3 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, or -N(CH 2 CH 2 OH) 2 ; Y is selected from one group of the following groups: RSO R 53 R 5 s Rs 9 R6o R 62 R 65 R 67 RLO R, R853 -CH 3 , R 52 RAM Rig P. 61 R R 66 R 6 R8 7 2 R '8 5 R R71 N I I R RlR'e R'g S R 8 R 8 R9 pN R'mi /' NRN N RIm2 R'rn2 R'm2\\ R'm i RR RimM \M3Rh 237 Rb 4 Rb 3 Rb Rb N N |MN rO Rmz N/ NRmz CN Rpli N Rp1 3 Rb 2 Rbi Rbi Rmz 1 Rpl 2 or Rpli N N N ~ Rpl 3 Rpl 2 wherein, R 50 , R 51 , R 5 2 , R 5 3 , R 5 4 , R 55 , R 56 , R 57 , R 58 , R 5 9 , R 60 , R 61 , R 62 , R 63 , R 6 4 , R 65 , R 66 , R 67 , R 68 , R 6 9 , R 70 , R 71 , R 72 and R 73 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 OH, -OH, -OCH 3 , -OCH 2 CH 3 , -CN, -NO 2 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , -F, -Cl, -Br, -I, or -C6H1, -C 6 H 4 -CH 3 , -C 6 H 4 -OH, -C 6 H 4 -NO 2 , or -C 6 H 4 -NH 2 ; R 77 , R 78 , R79, R 8 o and R 81 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OH, -OCH 3 , -OCH 2 CH 3 , -NO 2 , -CN, -COOH, -COOCH 3 , -COOCH 2 CH 3 , -F, -Cl, -Br, -I, -CF 3 , -CCl 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, or -N(CH 2 CH 2 OH) 2 ; R 85 , R 86 and R 8 7 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OH or -NH 2 ; R' 85 , R' 86 and R' 8 7 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -C 6 H 5 , or -CH 2 C 6 H 4 ; Q is selected from N, 0 or S; Rss, Rs 9 , R 90 , R' ss, R' 89 and R' 90 are respectively and independently selected from -H, -CH 2 CH 3 , -OH, -OCH 3 ,-OCH 2 CH 3 , -NO 2 , -NH 2 ,-NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , -CN, -COOH, -COOCH 3 , or -COOCH 2 CH 3 ; R 94 , R 9 5 , R' 94 and R' 95 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , -F, -Cl, -Br, -I, or -NHCOCH 3 , NHCOCH 2 CH 3 , or NHCOC 6 H 5 ; R 96 is selected from -H, -CH 3 , -CH 2 CH 3 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, or -N(CH 2 CH 2 OH) 2 ; R' 96 is selected from -H, -CH 3 , -CH 2 CH 3 , -C 6 H 5 , or -CH 2 C 6 H 4 ; Rmi, Rm2, Rm3, R mi, R m2 and R m3 are respectively and independently selected from 238 -H, -CH 3 , -CH 2 CH 3 , -F, -Cl, -Br, -I, -OH, -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , or -NHC 6 H 5 ; Rbl, Rb2, Rb3 and Rb4 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 OH, -OH, -OCH 3 , -OCH 2 CH 3 , -CN, -NO 2 , -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , -F, -Cl, -Br, or -I; Rmzi is selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 OH, -C 6 H 5 , or -CH 2 C 6 H 5 ; Rmz 2 and Rmz 3 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , -OCH 3 , -CH 2 OH, -NO 2 or -NH 2 , -NHCH 3 , -N(CH 3 ) 2 , -NHCH 2 CH 3 , -N(CH 2 CH 3 ) 2 , -NHCH 2 CH 2 OH, -N(CH 2 CH 2 OH) 2 , -CONH 2 , or -COOH; Rpii and Rp12 are respectively and independently selected from -H, -CH 3 , -CH 2 CH 3 , OH, -OCH 3 , -OCH 2 CH 3 , F, Cl, Br, or I; Rp 1 3 is selected from -H, -CH 3 , -CH 2 CH 3 , -CH 2 CH 2 OH, -C 6 H 5 , or -CH 2 C 6 H 5 .
2. The benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof according to claim 1, wherein X represents monosubstituted or polysubstitued or unsubstituted alkoxy, monosubstituted or polysubstitued or unsubstituted alkyl, monosubstituted or polysubstituted or unsubstituted alkenyl, monosubstituted or bisubstituted or unsubstituted thienyl, monosubstituted or bisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstituted pyridazinyl, monosubstituted or bisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or unsubstituted pyrazinyl, monosubstituted or bisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted phenyl, monosubstituted or bisubstituted or unsubstituted pyrimidinyl, monosubstituted or bisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or unsubstituted quinolinyl, monosubstituted or bisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or unsubstituted indolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrazolyl.
3. The benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof according to claim 2, wherein X represents C1-C6 alkyloxy substituted by nitro, amino, hydroxyl or aryl; , C1-C6 alkyl substituted by nitro, amino, hydroxyl or aryl; C2-C14 alkenyl substituted by alkyl, hydroxyl or aryl; thienyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted thienyl; pyidyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted pyridyl; quinolinyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted quinolinyl; indolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted indolyl; pyridyl monosubstituted or bisubstituted by C1-C6 alkoxy; pyridyl 239 monosubstituted or bisubstituted by C1-C3 dialkylamino; pyridyl monosubstituted or bisubstituted by C1-C6 alkyl; unsubstituted pyridyl; pyridazinyl monosubstituted by C1-C6 alkoxy; pyridazinyl monosubstituted by C1-C6 alkyl; unsubstituted pyridazinyl; unsubstituted piperazinyl; piperazinyl bisubstituted by C1-C6 alkyl; unsubstituted piperidinyl; unsubstituted pyrazinyl; unsubstituted thiazolyl; imidazolyl monosubstituted by nitro, amino or C1-C6 alkyl; unsubstituted imidazolyl; thiazolyl bisubstituted by C1-C6 alkyl and nitro; unsubstituted pyrimidinyl; pyrimidinyl monosubstituted by phenyl; pyrimidinyl bisubstituted by amino and a group selected from nitro, -F, -Cl, -Br or -I; phenyl trisubstituted by trihydroxyl; phenyl trisubstituted by trimethoxyl; phenyl bisubstituted by hydroxyl and methoxyl; imidazolyl substituted by a group selected from methyl, ethyl, carboxyl or amido; pyrazolyl bisubstituted or trisubstituted by a group selected from C1-C6 alkyl or aryl and a group selected from -F, -Cl, -Br or -I.
4. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof according to claim 1, wherein, Y represents hydroxyl, C1-C 6 alkyl, monosubstituted or bisubstituted or trisubstituted phenyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyridyl, monosubstituted or bisubstituted or unsubstitued pyrazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperazinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted pyrrolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted piperidinyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted thiazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzpyrimidinyl, monosubstituted or bisubstituted or trisubstituted or tetrasubstituted or unsubstituted benzimidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted benzimidazolonyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted imidazolyl, monosubstituted or bisubstituted or trisubstituted or unsubstituted purinyl.
5. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof according to claim 4, wherein, Y represents hydroxymethyl, hydroxyethyl, aminophenyl, hydroxyphenyl, C 1 -C 6 alkylphenyl, phenyl monosubstituted by -F, -Cl, -Br or -I, phenyl bisubstituted by hydroxyl and carboxyl, hydroxyethyl bisubstituted by hydroxylmethyl or C 1 -C 6 alkyl and monosubstituted phenyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C 1 -C 6 alkyl, pyridyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C 1 -C 6 alkyl, pyrazinyl monosubstituted or bisubstituted or unsubstituted, by C 1 -C 6 alkyl, piperazinyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C 1 -C 6 alkyl, pyrrolyl monosubstituted or bisubstituted or trisubstituted or unsubstituted by C 1 -C 6 alkyl, thiazolyl monosubstituted by C 1 -C 6 alkyl, 240 pyrimidinyl monosubstituted or bisubstituted or unsubstituted by C 1 -C 6 alkyl, pyrimidinyl monsubstituted by C 1 -C 6 alkyl and bisubstituted by hydroxyl, pyrimidinyl monosubstituted C 1 -C 6 alkyl and bisubstituted or trisubstituted by -F, -Cl, -Br or -I, purinyl monosubstituted or bisubstituted or unsubstituted by C 1 -C 6 alkyl, purinyl monosubstituted by C 1 -C 6 alky and substituted or trisuvstituted by hydroxyl.
6. The benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salt thereof according to claim 1, wherein, the derivatives are as follows: (1)(L)-2-(5-nitro-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide (2)(L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenyl hydroxyethyl)]amide (3)(L)-2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (4)2-(5-amino-2-thienyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxy ethyl)] amide (5)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (6)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-chlorophenyl)amide (7)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-bromophenyl)amide (8)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (9)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-chlorophenyl)amide (10)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-bromophenyl)amide (11)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (12)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-chlorophenyl)amide (13)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-bromophenyl)amide (14)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-methylphenyl)amide (15)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-hydroxylphenyl)amide (16)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (17)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-methylphenyl)amide (18)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-hydroxylphenyl)amide (19)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (20)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-methylphenyl)amide (21)2-(5-amino-2-thienyl)-1H-benzimidazole-4-(N-p-hydroxylphenyl)amide 241 (22)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (23)(L)-2-(4-methoxypyridyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-nitrophenylh ydroxyethyl)]amide (24)(L)-2-(4-methoxypyridyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (25)2-(4-methoxypyridyl)- 1H-benzimidazole-4-[N-(1 -methyl-2-p-chlorophenylhydroxyeth yl)]amide (26)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (27)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o-chlorophenyl)amide (28)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o-bromophenyl)amide (29)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (30)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (31)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (32)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (33)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (34)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (35)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (36)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (37)(L)-2-(6-methoxypyridyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-nitrophenylh ydroxyethyl)]amide (3 8)(L)-2-(6-methoxypyridyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-aminophenyl hydroxyethyl)]amide (39)2-(6-methoxypyridyl)- 1H-benzimidazole-4-[N-(1 -methyl-2-p-chlorophenylhydroxyeth yl)]amide (40)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (41)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (42)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (43)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (44)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (45)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (46)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide 242 (47)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (48)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (49)(L)-2-(4-dimethylaminopyridyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (50)(L)-2-(4-dimethylaminopyridyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (51)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophenylhydro xyethyl)]amide (52)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (53)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (54)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (55)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (56)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (57)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (58)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (59)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (60)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (61)(L)-2-(3-pyridazinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide (62)(L)-2-(3-pyridazinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (63)2-(3-pyridazinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]a mide (64)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl) amide (65)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl) amide (66)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl) amide (67)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl) amide (68)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-o-aminophenyl) amide (69)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl) amide (70)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-m-aminophenyl) amide (71)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide 243 (72)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-p-aminophenyl) amide (73)(L)-2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl 2-p-nitrophenylhydroxyethyl)]amide (74)(L)-2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl 2-p-aminophenylhydroxyethyl)]amide (75)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorop henylhydroxyethyl)]amide (76)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (77)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (78)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (79)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (80)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (81)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (82)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (83)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (84)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (85)(L)-2-(2-pyrazinyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydrox yethyl)]amide (86)(L)-2-(2-pyrazinyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (87)2-(2-pyrazinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (88)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (89)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (90)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (91)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (92)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (93)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (94)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (95)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (96)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (97)(L)-2-N-piperazinyl- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydrox 244 yethyl)]amide (98)(L)-2-N-piperazinyl- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (99)2-N-piperazinyl- 1H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophenylhydroxyethyl)] amide (100)2-N-piperazinyl- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (101)2-N-piperazinyl- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (102)2-N-piperazinyl- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (103)2-N-piperazinyl- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (104)2-N-piperazinyl- 1H-benzimidazole-4-(N-o-aminophenyl)amide (105)2-N-piperazinyl- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (106)2-N-piperazinyl- 1H-benzimidazole-4-(N-m-aminophenyl)amide (107)2-N-piperazinyl- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (108)2-N-piperazinyl- 1H-benzimidazole-4-(N-p-aminophenyl)amide (109)(L)-2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4- [N- (1 -hydroxymethyl-2-p-nit rophenylhydroxyethyl)]amide (110)(L)-2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-am inophenylhydroxyethyl)]amide (111)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylh ydroxyethyl)]amide (112)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (113)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (114)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (115)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (116)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (117)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (118)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (119)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (120)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (121)(L)-2-thiazolyl- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (122)(L)-2-thiazolyl- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxye 245 thyl)]amide (123)2-thiazolyl- 1H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophenylhydroxyethyl)] amide (124)2-thiazolyl- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (125)2-thiazolyl- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (126)2-thiazolyl- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (127)2-thiazolyl- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (128)2-thiazolyl- 1H-benzimidazole-4-(N-o-aminophenyl)amide (129)2-thiazolyl- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (130)2-thiazolyl- 1H-benzimidazole-4-(N-m-aminophenyl)amide (131)2-thiazolyl- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (132)2-thiazolyl- 1H-benzimidazole-4-(N-p-aminophenyl)amide (133)(L)-5-thiazolyl- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyeth yl)]amide (134)(L)-5-thiazolyl- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxye thyl)]amide (135)5-thiazolyl- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (136)5-thiazolyl- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (137)5-thiazolyl- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (138)5-thiazolyl- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (139)5-thiazolyl- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (140)5-thiazolyl- 1H-benzimidazole-4-(N-o-aminophenyl)amide (141)5-thiazolyl- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (142)5-thiazolyl- 1H-benzimidazole-4-(N-m-aminophenyl)amide (143)5-thiazolyl- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (144)5-thiazolyl- 1H-benzimidazole-4-(N-p-aminophenyl)amide (145)(L)-2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (146)(L)-2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (147)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydro xyethyl)]amide 246 (148)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (149)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (1 50)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (151)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1 52)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (153)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (1 54)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (155)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (156)2-(3,4,5-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (1 57)(L)-2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (158)(L)-2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (159)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophenylhydro xyethyl)]amide (1 60)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (161)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (1 62)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (163)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1 64)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (165)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (1 66)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (1 67)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (1 68)2-(2,3,4-trihydroxyphenyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (1 69)(L)-2-(2-pyrimidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (170)(L)-2-(2-pyrimidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhy droxyethyl)]amide (171)2-(2-pyrimidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (172)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (173)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide 247 (174)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (175)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (176)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (177) 2-(2-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (178)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (179)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (1 80)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-p-aminophenyl)amide (181)(L)-2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (1 82)(L)-2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (183)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydr oxyethyl)]amide (184)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-fluorophenyl)amide (185)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-fluorophenyl)amide (186)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-fluorophenyl)amide (187)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (188)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (189)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (190)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-m-aminophenyl)amide (191)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (192)2-(2- phenyl-5-pyrimidinyl)-1H-benzimidazole-4-(N-p-aminophenyl)amide (193)(L)-2-(4-amino-6-chloro-5 -pyrimidinyl)- 1 H-benzimidazole-4- [N- (1 -hydroxymethyl-2 -p-nitrophenylhydroxyethyl)] amide (194)(L)-2-(4-amino-6-chloro-5 -pyrimidinyl)- 1 H-benzimidazole-4- [N-(1 -hydroxymethyl-2 -p-aminophenylhydroxyethyl)]amide (195)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophe nylhydroxyethyl)]amide (1 96)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-o-fluorophenyl)amide (1 97)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-m-fluorophenyl)amide (1 98)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-p-fluorophenyl)amide 248 (1 99)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (200)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (201)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (202)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-m-aminophenyl)amide (203)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-p-hydroxyphenyl)amide (204)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-p-aminophenyl)amide (205)(L)-2-(2-pyrrolyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (206)(L)-2-(2-pyrrolyl)- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (207)2-(2-pyrrolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (208)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (209)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (210)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (211)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (212)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (213)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (214)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (215)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (216)(L)-2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophe nylhydroxyethyl)]amide (217)(L)-2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminoph enylhydroxyethyl)]amide (218)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxy ethyl)]amide (219)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (220)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (221)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (222)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (223)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (224)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide 249 (225)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (226)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (227)(L)-2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (228)(L)-2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (229)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-[N-(1 -methyl-2-p-chlorophenylhydr oxyethyl)]amide (230)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (231)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (232)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (233)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (234)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (235)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (236)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (237)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (238)(L)-2-(2-quinolinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide (239)(L)-2-(2-quinolinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (240)2-(2-quinolinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (241)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (242)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (243)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (244)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (245)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (246)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (247)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (248)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (249)(L)-2-(3-quinolinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydro xyethyl)]amide 250 (250)(L)-2-(3 -quinolinyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-aminophenylhydr oxyethyl)]amide (251)2-(3-quinolinyl)- 1 H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophenylhydroxyethyl)] a mide (252)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (253)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (254)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (255)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (256)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (257)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (258)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (259)2-(3-quinolinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (260)(L)-2-(2-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (261)(L)-2-(2-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide (262)2-(2-piperidinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (263)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (264)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (265)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (266)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (267)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (268)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (269)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (270)2-(2-piperidinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (271)(L)-2-(3-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (272)(L)-2-(3-piperidinyl)- 1H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide (273)2-(3-piperidinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (274)2-(3-piperidinyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide 251 (275)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-m-fluorophenyl)amide (276)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-p-fluorophenyl)amide (277)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (278)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (279)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (280)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-m-aminophenyl)amide (281)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-p-hydroxyphenyl)amide (282)(L)-2-(4-piperidinyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (283)(L)-2-(4-piperidinyl)- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-aminophenylhyd roxyethyl)]amide (284)2-(4-piperidinyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (285)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-o-fluorophenyl)amide (286)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-m-fluorophenyl)amide (287)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-p-fluorophenyl)amide (288)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (289)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (290)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-m-hydroxyphenyl)amide (291)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-m-aminophenyl)amide (292)2-(4-piperidinyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (293)(L)-2-(3-indolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (294)(L)-2-(3-indolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydrox yethyl)]amide (295)2-(3-indolyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (296)2-(3-indolyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (297)2-(3-indolyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (298)2-(3-indolyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (299)2-(3-indolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (300)2-(3-indolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (301)2-(3-indolyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide 252 (302)2-(3-indolyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (303)2-(3-indolyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (304)(L)-2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrop henylhydroxyethyl)]amide (305)(L)-2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-amino phenylhydroxyethyl)]amide (306)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydr oxyethyl)]amide (307)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (308)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (309)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (310)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (311)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (312)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (313)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (314)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (315)(L)-2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p nitrophenylhydroxyethyl)] amide (316)(L)-2-(3 -hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p aminophenylhydroxyethyl)]amide (317)2-(3 -hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4- [N-(1 -methyl-2-p-chloropheny lhydroxyethyl)]amide (318)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-o-fluorophenyl)amide (319)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-m-fluorophenyl)amide (320)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-p-fluorophenyl)amide (321)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (322)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (323)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-m-hydroxyphenyl)amide (324)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-m-aminophenyl)amide (325)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-p-hydroxyphenyl)amide (326)(L)-2-methoxy- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyeth 253 yl)]amide (327)(L)-2-methoxy- 1H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-aminophenylhydroxye thyl)]amide (328)2-methoxy- 1H-benzimidazole-4- [N-(1 -methyl-2-p-chlorophenylhydroxyethyl)] amide (329)2-methoxy- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (330)2-methoxy- 1H-benzimidazole-4-(N-2-piperazinyl)amide (331)2-methoxy- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (332)2-methoxy- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (333)2-methoxy- 1H-benzimidazole-4-(N-o-aminophenyl)amide (334)2-methoxy- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (335)2-methoxy- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (336)2-methoxy- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (337)2-methoxy- 1H-benzimidazole-4-(N-2-imidazolyl)amide (338)2-methoxy- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (339)2-methoxy- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (340)2-methoxy- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (341)2-methoxy- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (342)2-methoxy- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (343)2-methoxy- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (344)2-methoxy- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (345)2-methoxy- 1H-benzimidazole-4-(N-2-pyridyl)amide (346)2-methoxy- 1H-benzimidazole-4-(N-3-pyridyl)amide (347)2-methoxy- 1H-benzimidazole-4-(N-4-pyridyl)amide (348)2-methoxy- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (349)2-methoxy- 1H-benzimidazole-4-(N-5-thiazolyl)amide (350)2-methoxy- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (351)2-methoxy- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (352)2-methoxy- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (353)2-methoxy- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (354)(L)-2-ethoxy- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl )]amide 254 (355)(L)-2-ethoxy- 1 H-benzimidazole-4-[N-(1 -hydroxymethyl-2-p-aminophenylhydroxyeth yl)]amide (356)2-ethoxy- 1H-benzimidazole-4-[N-(1 -methyl-2-p-chlorophenylhydroxyethyl)] amide (357)2-ethoxy- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (358)2-ethoxy- 1H-benzimidazole-4-(N-2-piperazinyl)amide (359)2-ethoxy- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (360)2-ethoxy- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (361)2-ethoxy- 1H-benzimidazole-4-(N-o-aminophenyl)amide (362)2-ethoxy- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (363)2-ethoxy- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (364)2-ethoxy- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (365)2-ethoxy- 1H-benzimidazole-4-(N-2-imidazolyl)amide (366)2-ethoxy- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (367)2-ethoxy- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (368)2-ethoxy- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (369)2-ethoxy- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (370)2-ethoxy- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (371)2-ethoxy- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (372)2-ethoxy- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (373)2-ethoxy- 1H-benzimidazole-4-(N-2-pyridyl)amide (374)2-ethoxy- 1H-benzimidazole-4-(N-3-pyridyl)amide (375)2-ethoxy- 1H-benzimidazole-4-(N-4-pyridyl)amide (376)2-ethoxy- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (377)2-ethoxy- 1H-benzimidazole-4-(N-5-thiazolyl)amide (378)2-ethoxy- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (379)2-ethoxy- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (380)2-ethoxy- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (381)2-ethoxy- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (382)(L)-2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-ni trophenylhydroxyethyl)] amide (383)(L)-2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4- [N-(1 -hydroxymethyl-2-p-a 255 minophenylhydroxyethyl)] amide (3 84)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4- [N-( 1 -methyl-2-p-chlorophenyl hydroxyethyl)] amide (3 85)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (3 86)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2-piperazinyl)amide (3 87)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (38 8)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (3 89)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (3 90)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (391 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazol yl)amide (392)2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (393 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (3 94)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (395 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (3 96)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (3 97)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (3 98)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (3 99)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (400)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (401 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (402)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (403 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (404)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (405 )2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (406)2-(2,6-dimnethyl-2,6-octadienyl)- 1H-benziniidazole-4-(N-2,4-dihydroxyl-5-pyriniidinyl)amiide (407)2-(2,6-dimnethyl-2,6-octadienyl)- 1H-benziniidazole-4-(N-4,6-dimethoxy-2-pyriniidinyl)amiide (408)2-(2,6-dimethyl-2,6-octadienyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidi nyl)amide (409)2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (410)(L)-2-pyrazolyl- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide 256 (411)(L)-2-pyrazolyl-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydroxyethyl)]amide (412) 2-pyrazolyl-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (413) 2-pyrazolyl-1H-benzimidazole-4-(N-N'-piperidinyl)amide (414) 2-pyrazolyl-1H-benzimidazole-4-(N-2-piperazinyl)amide (415) 2-pyrazolyl-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (416) 2-pyrazolyl-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (417) 2-pyrazolyl-1H-benzimidazole-4-(N-o-aminophenyl)amide (418) 2-pyrazolyl-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (419) 2-pyrazolyl-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (420) 2-pyrazolyl-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (421) 2-pyrazolyl-1H-benzimidazole-4-(N-2-imidazolyl)amide (422) 2-pyrazolyl-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (423) 2-pyrzazolyl-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (424) 2-pyrazolyl-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (425) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrazinyl)amide (426) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (427) 2-pyrazolyl-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (428) 2-pyrazolyl-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (429) 2-pyrazolyl-1H-benzimidazole-4-(N-2-pyridyl)amide (430) 2-pyrazolyl-1H-benzimidazole-4-(N-3-pyridyl)amide (431) 2-pyrazolyl-1H-benzimidazole-4-(N-4-pyridyl)amide (432) 2-pyrazolyl-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (433) 2-pyrazolyl-1H-benzimidazole-4-(N-5-thiazolyl)amide (434) 2-pyrazolyl-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (435) 2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (436) 2-pyrazolyl-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (437) 2-pyrazolyl-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (438)(L)-2-(2'-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxy ethyl)]amide (439)(L)-2-(2'-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide 257 (440)2-(2'-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (441) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (442) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (443) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (444) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (445) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-o-aminophenyl)amide (446) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (447) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (448) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (449) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-imidazolyl)amide (450) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4'-pyrazolyl)amide (451) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-(N'-piperazinyl))amide (452) 2-(2'-pyridyl)-1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (453) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-pyrazinyl)amide (454) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-pyrimidinyl)amide (455) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4-pyrimidinyl)amide (456) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-5-pyrimidinyl)amide (457) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-2-pyridyl)amide (458) 2-(2'-pyridyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (459) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (460) 2-(2'-pyridyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (461)2-(2'-pyridyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (462)2-(2'-pyridyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (463)2-(2'-pyridyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (464)2-(2'-pyridyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (465)2-(2'-pyridyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (466)(L)-2-(3'-pyridyl)-1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydroxyethyl)]amide (467)(L)-2-(3'-pyridyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhydro xyethyl)]amide (468)2-(3'-pyridyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (469)2-(3'-pyridyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide 258 (470)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-2-piperazinyl)amide (471 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (472)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (473 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (474)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (475 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (476)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (477)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (478)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (479)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (480)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (481 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (482)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (483 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (484)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (485 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (486)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (487)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (48 8)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (489)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (490)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (491 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (492)2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (493 )2-(3 '-pyridyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (494)(L)-2-(4'-pyridyl)- 1H-benzimidazole-4-[N-(1-hydmoxymethyl-2-p-nitrophenylhydroxyethyl)]amide (495 )(L)-2-(4 '-pyridyl)- 1 H-benzimidazole-4- [N-(l1-hydroxymethyl-2-p-aminophenylhydro xyethyl)] amide (496)2- (4' -pyridyl)- 1H-benzimidazole-4-[N-(l1-methyl-2-p-chlorophenylhydroxyethyl)] amide (497)2-(4' -pyridyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (498)2-(4' -pyridyl)- 1 H-benzimidazole-4-(N-2-piperazinyl)amide (499)2-(4' -pylidyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide 259 (500)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (501)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (502)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (503)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (504)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (505)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (506)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (507)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (508)2-(4'-pyridyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (509)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (510)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (511)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (512)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (513)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (514)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (515)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (516)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (517)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (518)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (519)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (520)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (521)2-(4'-pyridyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (522)(L)-2-(2'-imidazolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-nitrophenylhydr oxyethyl)]amide (523)(L)-2-(2'-imidazolyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p-aminophenylhy droxyethyl)]amide (524)2-(2'-imidazolyl)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (525)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (526)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide (527)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (528)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide 260 (529)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-o-aminophenyl)amide (530)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (531)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (532)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (533)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (534)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (535)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (536)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (537)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (53 8)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (539)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (540)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (541)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (542)2-(2'-imidazolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (543)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4-pyridyl)amide (544)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (545)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-5-thiazolyl)amide (546)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (547)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (548)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (549)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (550)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (551)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide (552)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (553)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (554)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (555)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (556)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (557)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (558)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide 261 (559)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (560)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (561)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (562)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (563)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (564)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (565)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (566)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (567)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (568)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (569)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (570)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (571)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (572)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (573)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (574)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-piperazinyl)amide (575)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (576)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (577)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (578)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (579)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (580)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (581)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (582)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (583)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (584)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (585)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (586)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (587)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (588)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide 262 (589)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (590)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (591)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (592)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (593)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (594)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (595)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (596)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (597)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (598)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2' -benzimidazolyl)amide (599)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (600)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (601)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (602)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (603)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4' -pyrazolyl)amide (604)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-(N' -piperazinyl))amide (605)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (606)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (607)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (608)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (609)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (610)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (611)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (612)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (613)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (614)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (615)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (616)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (617)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (618)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 263 (61 9)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (620)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (621 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (622)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (623 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (624)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (625 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (626)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (627)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (628)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (629)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (630)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (631 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (632)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (633 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (634)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (635 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (63 6)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (637)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (63 8)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (63 9)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (640)2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (641 )2-(3-pyridazinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (642)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (643 )2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-2-piperazinyl))amide (644)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-2' -benzimidazolyl)amide (645)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (646)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imid azolyl)amide (647)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazol yl)amide 264 (648)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-2-imidazolyl)amide (649)2-(2-N-methyl-4- N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (650)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-(N' -piperazinyl))amide (65 1)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (652)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-2-pyrazinyl)amide (653 )2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-2-pyrimidinyl)amide (654)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-4-pyrimidinyl)amide (655 )2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-5 -pyrimidinyl)amide (65 6)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-2-pyridyl)amide (657)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-3 -pyridyl)amide (65 8)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-4-pyridyl)amide (65 9)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benziimidazole-4-(N-4-methyl-5-thiazolyl)amide (660)2-(2-N-methyl-4- N-methylpiperazinyl)-l1H-benzimidazole-4-(N-5 -thiazolyl)amide (661 )2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimi dinyl)amide (662)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimi dinyl)amide (663 )2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyri midinyl)amide (664)2-(2-N-methyl-4-N-methylpiperazinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidi nyl)amide (665 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-N' -piperidinyl)amide (666)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2-piperazinyl))amide (667)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2' -benzimidazolyl)amide (668)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (669)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (67O)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (671 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2-imidazolyl)amide (672)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4' -pyrazolyl)amide (673 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-(N' -piperazinyl))amide (674)2-(2-pyrazinyl)-l H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide 265 (675 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2-pyrazinyl)amide (676)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2-pyrimidinyl)amide (677)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4-pyrimidinyl)amide (678)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-5 -pyrimidinyl)amide (679)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2-pyridyl)amide (68O)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-3 -pyridyl)amide (681 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4-pyridyl)amide (682)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (683 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-5 -thiazolyl)amide (684)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (685 )2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (686)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (687)2-(2-pyrazinyl)-l H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (68 8)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (689)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (690)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (691 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (692)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (693 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (694)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (695 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (696)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (697)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (698)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (699)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (700)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (701 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (702)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (703 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (704)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide 266 (705 )2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (706)2-(2-piperazinyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (707)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (708)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (709)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (71 O)2-(2-piperazinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (711 )2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (71 2)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (713 )2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (71 4)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (7 15)2-(4-methyl-5-aminothiazolyl)- 1H-benziniidazole-4-(N-4' -carbonamido-5 '-iniidazolyl)amide (71 6)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (71 7)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (71 8)2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (71 9)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (720)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (721 )2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (722)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (723 )2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (724)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (725 )2-(4-methyl-5-amiinothiazolyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (726)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (727)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (728)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (729)2-(4-methyl-5-aminothiazolyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (73 O)2-(4-methyl-5-aminothiazolyl)- 1H-benziniidazole-4-(N-2,4-dihydroxyl-5-pyriniidinyl)amide (73 1)2-(4-methyl-5-aminothiazolyl)- 1H-benziniidazole-4-(N-4,6-dimnethoxy-2-pyriniidinyl)amide (732)2-(4-methyl-5 -aminothiazolyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidi nyl)amide (733)2-(4-methyl-5-aminothiazolyl)- 1H-benziniidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amiide (734)2-(2-thiazolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide 267 (735)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (736)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (737)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (73 8)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (739)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (740)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (741)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (742)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (743)2-(2-thiazolyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (744)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (745)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (746)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (747)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (748)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (749)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (750)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (751)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (752)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (753)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (754)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (755)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (756)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (757)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (758)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (759)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (760)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (761)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (762)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (763)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (764)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide 268 (765)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (766)2-(5-thiazolyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (767)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (768)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (769)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (770)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (771)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (772)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (773)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (774)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (775)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (776)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (777)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (778)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (779)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (780)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (781)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (782)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (783)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (784)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (785)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (786)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (787)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (788)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (789)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (790)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (791)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (792)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (793)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (794)2-(2-pyrimidinyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide 269 (795 )2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (796)2-(2- pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (797)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (798)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (799)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (800)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (801 )2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (802)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (803 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (804)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (805 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2 ' -benzimidazolyl)amide (806)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (807)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (808)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4 '-carboxyl-5 '-imidazolyl)amide (809)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (81 0)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4 ' -pyrazolyl)amide (811 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (81 2)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (813 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (81 4)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (815 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (81 6)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (81 7)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (81 8)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (81 9)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (820)2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (821 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (822)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (823)2-(2-phenyl-5 -pyrimidinyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (824)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amiide 270 (825 )2-(2-phenyl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (826)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (827)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (828)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (829)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (830)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidaz olyl)amide (83 1)2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benziniidazole-4-(N-4' -carboxyl-5 '-iniidazolyl)amide (832)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (833 )2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (834)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (835 )2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (83 6)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (837)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (83 8)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (83 9)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (840)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (841 )2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (842)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (843)2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benziniidazole-4-(N-4-methyl-5-thiazolyl)amide (844)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (845 )2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidi nyl)amide (846)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidin yl)amide (847)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimi dinyl)amide (848)2-(4-amino-6-chloro-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl )amide (849)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (85O)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide 271 (851 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (852)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (853 )2-(2-pyrrolyl)-l1H-benzimidazole-4-(N-4' - carbonamido -5' -imidazolyl)amide (854)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (855 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (85 6)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (857)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (85 8)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (85 9)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (86O)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (861 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (862)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (863 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (864)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (865 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (866)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (867)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (868)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (869)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (87O)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (871 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (872)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (873 )2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (874)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (875 )2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (876)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (877)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (878)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (879)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (8 80)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide 272 (881 )2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (8 82)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (883 )2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (8 84)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (885 )2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (8 86)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (8 87)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (88 8)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (8 89)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (890)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (891 )2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (892)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (893)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amiide (894)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (895 )2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (896)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (897)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (898)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (899)2-(3 ,5-dimethyl-2-pyrrolyl)- 1H-benziniidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (900)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (901 )2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (902)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (903 )2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (904)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (905 )2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (906)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (907)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (908)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (909)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (91 0)2-(3 ,5-dimnethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide 273 (911)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (912)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (913)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (914)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (915)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (916)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (917)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (918)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (919)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (920)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (921)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (922)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (923)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (924)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (925)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (926)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (927)2-(2-quinolinyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (928)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (929)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (930)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (931)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (932)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (933)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (934)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (935)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (936)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (937)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (938)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (939)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (940)2-(2-quinolinyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide 274 (941 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (942)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (943 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (944)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (945 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (946)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (947)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (948)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (949)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (950)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (951 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (952)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (953 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (954)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (955 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (95 6)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (957)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (95 8)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (95 9)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (960)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (961 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (962)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (963 )2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (964)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (965 )2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (966)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (967)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (968)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (969)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (970)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide 275 (971 )2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (972)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (973 )2-(3-piperidinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (974)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (975 )2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (976)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (977)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (978)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (979)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (980)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (981 )2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (982)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (983 )2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (984)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (985 )2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (986)2-(3-piperidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (987)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (98 8)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (989)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (990)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (991 )2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (992)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (993 )2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (994)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (995 )2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (996)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (997)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (998)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (999)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1 OO)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide 276 (1001)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (1002)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (1003)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (1004)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1005)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-5-thiazolyl)amide (1006)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1007)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide (1008)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1009)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1010)2-(3-indolyl)- 1H-benzimidazole-4-(N-N'-piperidinyl)amide (1011 )2-(3-indolyl)- 1H-benzimidazole-4-(N-2-piperazinyl))amide (1012)2-(3-indolyl)- 1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1013 )2-(3-indolyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1014)2-(3-indolyl)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (1015 )2-(3-indolyl)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (101 6)2-(3-indolyl)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (1017)2-(3-indolyl)- 1H-benzimidazole-4-(N-4'-pyrazolyl)amide (101 8)2-(3-indolyl)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (101 9)2-(3-indolyl)- 1H-benzimidazole-4-(N'-ethyl-N-piperazinyl)amide (1020)2-(3-indolyl)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (1021)2-(3-indolyl)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1022)2-(3-indolyl)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1023)2-(3-indolyl)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1024)2-(3-indolyl)- 1H-benzimidazole-4-(N-2-pyridyl)amide (1025)2-(3-indolyl)- 1H-benzimidazole-4-(N-3-pyridyl)amide (1026)2-(3-indolyl)- 1H-benzimidazole-4-(N-4-pyridyl)amide (1027)2-(3-indolyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1028)2-(3-indolyl)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (1029)2-(3-indolyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1030)2-(3-indolyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidinyl)amide 277 (1031 )2-(3-indolyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1 032)2-(3-indolyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (1033 )2-(2,3 ,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (1 034)2-(2,3 ,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (1035 )2-(2,3 ,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (103 6)2-(2,3 ,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (1037)2-(2,3,4-trimethoxyphenyl)- 1H-benziimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (103 8)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (103 9)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (1 040)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (1041 )2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (1 042)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (1043 )2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1 044)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (1045 )2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1 046)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (1 047)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (1 048)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (1 049)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (1 050)2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (1051 )2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (1052)2-(2,3 ,4-trimethoxyphenyl)- 1H-benzincdazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1053)2-(2,3 ,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-4,6-dimnethoxy-2-pyrimidinyl)amiide (1054)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1055 )2-(2,3,4-trimethoxyphenyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (105 6)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (1 057)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (105 8)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (105 9)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (1 060)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazol yl)amide 278 (1061 )2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (1 062)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (1063 )2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (1 064)2-(3-hydroxyl-4-methoxtphenyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (1065 )2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (1 066)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1 067)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (1 068)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1 069)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (1 070)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (1071 )2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (1 072)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (1073 )2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (1 074)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (1075 )2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidin yl)amide (1 076)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimidiny 1)amide (1 077)2-(3-hydroxyl-4-methoxyphenyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimid inyl)amide (1078)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1 079)(L)-2-(2-bromo-5 -pyridine)- 1H-benzimidazole-4-[N-(l1-hydroxymethyl-2-p-nitrophenylhy droxyethyl)] amide (1 080)(L)-2-(2-bromo-5 -pyridine)- 1H-benzimidazole-4-[N-(l1-hydroxymethyl-2-p-aminophenylh ydroxyethyl)]amide (108 1)2-(2-bmomo-5-pyridine)- 1H-benzimidazole-4-[N-(1-methyl-2-p-cffiomphenylhydmoxyethyl)]amide (1 082)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (1083 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (1 084)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (1085 )2-(2-bromo-5 -pyridine)- 1H-benziimidazole-4-(N-o-hydroxyphenyl)amide (1 086)2-(2-bromo-5 -pyridine)- 1H-benziimidazole-4-(N-o-aminophenyl)amide 279 (1 087)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (108 8)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imidazolyl)amide (1 089)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazolyl)amide (1 090)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (1091 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (1 092)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (1093 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (1 094)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1095 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (1 096)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1 097)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (1 098)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (1 099)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (1 100)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (1 101 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4-methyl-5 -thiazolyl)amide (1 102)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-5 -thiazolyl)amide (1 103 )2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidinyl)amide (1 104)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4,6-di(2-bromo-5 -pyridine)-2-pyrimi dinyl)amide (1 105)2-(2-bromo-5-pyridine)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1 106)2-(2-bromo-5-pyridine)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidinyl)amide (1 107)(L)-2-(2-amino-3 -pyridine)- 1H-benziniidazole-4-[N-( 1-hydroxymethyl-2-p-nitrophenylhy droxyethyl)] amide (1 108)(L)-2-(2-amino-3 -pyridine)- 1H-benziniidazole-4-[N-( 1-hydroxymethyl-2-p-aminophenylh ydroxyethyl)]amide (1 109)2-(2-am-ino-3-pyidine)-1H-benzimidazole-4-[N-(1-methyl-2-p-chlorophenylhydroxyethyl)]amide (11 10)2-(2-amino-3-pyridine)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (111 1)2-(2-amino-3-pyridine)- 1 H-benzimidazole-4-(N-2-piperazinyl))amide (11 12)2-(2-amino-3-pyridine)- 1 H-benzimidazole-4-(N-2' -benzimidazolyl)amide (11 13 )2-(2-amino-3-pyridine)- 1H-benziniidazole-4-(N-o-hydroxyphenyl)amide (11 14)2-(2-amino-3-pyridine)- 1H-benziniidazole-4-(N-o-aminophenyl)amide 280 (1115)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1116)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4'-carbonamido-5'-imidazolyl)amide (1117)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4'-carboxyl-5'-imidazolyl)amide (1118)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-imidazolyl)amide (1119)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4' -pyrazolyl)amide (1120)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-(N'-piperazinyl))amide (1121)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (1122)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-pyrazinyl)amide (1123)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-pyrimidinyl)amide (1124)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1125)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-5-pyrimidinyl)amide (1126)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-pyridyl)amide (1127)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-3-pyridyl)amide (1128)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4-pyridyl)amide (1129)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1130)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-5-thiazolyl)amide (1131)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrimidinyl)amide (1132)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4,6-di(2-amino-3-pyridine)-2-pyrimid inyl)amide (1133)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrimidinyl)amide (1134)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (1135)(L)-2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p nitrophenylhydroxyethyl)]amide (1136)(L)-2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-hydroxymethyl-2-p aminophenylhydroxyethyl)]amide (1137)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-[N-(1-methyl-2-p-chloropheny lhydroxyethyl)]amide (1138)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-N'-piperidinyl)amide (1139)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-piperazinyl)amide (1140)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2'-benzimidazolyl)amide (1141)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-o-hydroxyphenyl)amide 281 (11 42)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-o-aminophenyl)amide (1 143)2-(2-pyrrolidine- l-yl-5 -pyrimidinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (11 44)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4' -carbonamido-5 '-imida zolyl)amide (1 145 )2-(2-pyrrolidine- l-yl-5-pyrimidinyl)- 1H-benziniidazole-4-(N-4'-carboxyl-5 '-iniidazolyl)amide (11 46)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-imidazolyl)amide (11 47)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4' -pyrazolyl)amide (11 48)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-(N' -piperazinyl))amide (1 149)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (11 50)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyrazinyl)amide (1151 )2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyrimidinyl)amide (11 52)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1153 )2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-5 -pyrimidinyl)amide (11 54)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyridyl)amide (1155 )2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-3 -pyridyl)amide (115 6)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-5 -pyridyl)amide (11 57)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (115 8)2-(2-pyrrolidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-5 -thiazolyl)amide (115 9)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimid inyl)amide (11 60)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4,6-di(2-pyrrolidine- 1 yl-S -pyrimidinyl)-2-pyrimidinyl)amide (1161 )2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyri midinyl)amide (11 62)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidin yl)amide (1163 )(L)-2-(2-piperidine- l-yl-S -pyrimidinyl)- 1H-benziniidazole-4-[N-(l1-hydroxymethyl-2-p-n itrophenylhydroxyethyl)]amide (11 64)(L)-2-(2-piperidine- 1-yl-5-pyimidinyl)- 1H-benziniidazole-4-[N-( 1-hydroxymethyl-2-p-amii nophenylhydroxyethyl)]amide (1165 )2-(2-piperidine- 1-yl-5-pyrimidinyl)- 1H-benziniidazole-4-[N-( 1-methyl-2-p-chlorophenylhy droxyethyl)] amide 282 (1 166)2-(2-piperidine- 1-yl-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (11 67)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-piperazinyl)amide (11 68)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2' -benzimidazolyl)amide (11 69)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (11 70)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-o-aminophenyl)amide (1171 )2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-5 -benzimidazolonyl)amide (11 72)2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4' -carbonamido-5 '-imidaz olyl)amide (1 173 )2-(2-piperidine- 1-yl-5-pyrimidinyl)- 1H-benziimidazole-4-(N-4'-catboxyl-5 '-imidazolyl)amide (11 74)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-imidazolyl)amide (1175 )2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4' -pyrazolyl)amide (11 76)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-(N' -piperazinyl))amide (1 177)2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (11 78)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyrazinyl)amide (11 79)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyrimidinyl)amide (11 80)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-pyrimidinyl)amide (1181 )2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-5 -pyrimidinyl)amide (11 82)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2-pyridyl)amide (1183 )2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-3 -pyridyl)amide (11 84)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-pyridyl)amide (11 85)2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (11 86)2-(2-piperidine- 1- yl-5-pyrimidinyl)-l1H-benzimidazole-4-(5 -thiazolyl)amide (11 87)2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrimidi nyl)amide (118 8)2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4,6-di(2-piperidine- l-yl-S pyrimidinyl)-2-pyrimidinyl)amide (11 89)2-(2-piperidine- 1-yl-5-pyrimidinyl)-l1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyrim idinyl)amide (1 190)2-(2-piperidine- 1-yl-5-pyrimidinyl)- 1H-benziimidazole-4-(N-4,6-dichloro-5-pyrimidinyl)amide (119 1)(L)-2-(2-cyclopropylamino-5 -pyrimidinyl)- 1H-benzimidazole-4-IIN-(1-hydroxymethyl-2 p-nitrophenylhydroxyethyl)]amide 283 (1 192)(L)-2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benziniidazole-4-[N-(l1-hydroxymethyl-2-p aminophenylhydroxyethyl)] amide (1 193 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-[N-( 1-methyl-2-p-chlorophenyl hydroxyethyl)]amide (1 194)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (1 195 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-piperazinyl)amide (1 196)2-(2-cyclopropylamino-5-pyriniidinyl)- 1H-benzimidazole-4-(N-2' -benzimidazolyl)amide (1 197)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1 198)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (11 99)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N-5-benzimidazolonyl)amide (1 200)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imi dazolyl)amide (1201 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazo lyl)amide (1 202)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (1203 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (1 204)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (1205 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N' -ethyl-N-piperazinyl)amide (1 206)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1 207)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (1 208)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1 209)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (121 0)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (1211 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (121 2)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide (12 13)2-(2-cyclopropylamino-5-pyrimidinyl)- 1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (121 4)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(5 -thiazolyl)amide (1215 )2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-2,4-dihydroxyl-5 -pyrim idinyl)amide (121 6)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-di(2-cyclopropylam mno-S -pyrimidinyl)-2-pyrimidinyl)amide 284 (121 7)2-(2-cyclopropylamiino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4-chloro-6-amino-2-py rimidinyl)amide (121 8)2-(2-cyclopropylamino-5-pyrimidinyl)- 1 H-benzimidazole-4-(N-4,6-dichloro-5 -pyrimidi nyl)amide (121 9)(L)-2-( 1,3-dimethyl-5 -chloro-4-pyrazolyl)- 1H-benziniidazole-4-[N-( 1-hydroxymethyl-2 p-nitrophenylhydroxyethyl)]amide (1 220)(L)-2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1H-benziniidazole-4-[N-(l1-hydroxymethyl-2-p-a minophenylhydroxyethyl)] amide (1221 )2-( 1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benziniidazole-4-[N-(1 -methyl-2-p-chlorophenyl hydroxyethyl)]amide (1 222)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-N' -piperidinyl)amide (1223 )2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-2-piperazinyl)amide (1224)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1H-benziniidazole-4-(N-2' -benzimidazolyl)amide (1225 )2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-o-hydroxyphenyl)amide (1 226)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-o-aminophenyl)amide (1227)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1H-benziniidazole-4-(N-5-benziniidazolonyl)amiide (1 228)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-4' -carbonamido-5 '-imid azolyl)amide (1 229)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-4' -carboxyl-5 '-imidazol yl)amide (1 230)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-2-imidazolyl)amide (1231 )2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-4' -pyrazolyl)amide (1 232)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-(N' -piperazinyl))amide (123 3)2-( 1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benziniidazole-4-(N' -ethyl-N-piperazinyl)amide (1 234)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-2-pyrazinyl)amide (1235 )2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-2-pyrimidinyl)amide (123 6)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-4-pyrimidinyl)amide (1 237)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-5 -pyrimidinyl)amide (123 8)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-2-pyridyl)amide (123 9)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-3 -pyridyl)amide (1 240)2-( 1,3-dimnethyl-5-chloro-4-pyrazolyl)- 1 H-benzimidazole-4-(N-4-pyridyl)amide 285 (1241)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-4-methyl-5-thiazolyl)amide (1242)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(5-thiazolyl)amide (1243)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-2,4-dihydroxyl-5-pyrim idinyl)amide (1244)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-4,6-dimethoxy-2-pyrimi dinyl)amide (1245)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-4-chloro-6-amino-2-pyr imidinyl)amide (1246)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)- 1H-benzimidazole-4-(N-4,6-dichloro-5-pyrimidi nyl)amide (1247)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1248)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1249)2-(4-methoxypyridyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1250)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1251)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1252)2-(5-amino-2-thienyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1253)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1254)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1255)2-(6-methoxypyridyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1256)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1257)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1258)2-(4-dimethylaminopyridyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1259)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1260)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1261)2-(3-pyridazinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1262)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrim idinyl)amide (1263)2-(2-N-methyl-4-N-methylpiperazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1264)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1265)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1266)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide 286 (1 267)2-(2-pyrazinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 268)2-N-piperazinyl-l1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1 269)2-N-piperazinyl- 1 H-benzimidazole-4-(N-6-purinyl)amide (1 270)2-N-piperazinyl- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1271 )2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amiide (1 272)2-(4-methyl-5 -aminothiazolyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1273 )2-(4-methyl-5 -aminothiazolyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 274)2-thiazolyl- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1275 )2-thiazolyll- 1 H-benzimidazole-4-(N-6-purinyl)amide (1 276)2-thiazolyl- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1277)5 -thiazolyl- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1278)5 -thiazolyl- 1 H-benzimidazole-4-(N-6-purinyl)amide (1279)5 -thiazolyl- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 280)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1281 )2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1 282)2-(2-pyrimidinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1283)2-(2-phenyl-5 -pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 284)2-(2-phenyl-5 -pyrimidinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1285 )2-(2-phenyl-5 -pyrimidinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 286)2-(4-amino-6-chloro-5 -pyrimidinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1 287)2-(4-amino-6-chloro-5 -pyrimidinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (128 8)2-(4-amiino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 289)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 29O)2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1291 )2-(2-pyrrolyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 292)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1293 )2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1 294)2-(N-methyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1295)2-(3 ,5 -dimethyl-2-pyrrolyl)-l1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 296)2-(3 ,5 -dimethyl-2-pyrrolyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide 287 (1297)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1298)2-(2-quinolinyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1299)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1300)2-(2-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1301)2-(3-quinolinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1302)2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1303)2-(3-quinolinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1304)2-(2-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1305)2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1306)2-(2-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1307)2-(3-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1308)2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1309)2-(3-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1310)2-(4-piperidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1311)2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1312)2-(4-piperidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1313)2-(3-indolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1314)2-(3-indolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1315)2-(3-indolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1316)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1317)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1318)2-(2,3,4-trimethoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1319)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1320)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1321)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1322)2-methoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1323)2-methoxy-1H-benzimidazole-4-(N-6-purinyl)amide (1324)2-methoxy-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1325)2-ethoxy-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1326)2-ethoxy-1H-benzimidazole-4-(N-6-purinyl)amide 288 (1 327)2-ethoxy- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1328)2-(2,6-dimethyl-2,6-octadienyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 329)2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1330)2-(2,6-dimethyl-2,6-octadienyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1331)2-pyrazolyl- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1332)2- pyrazolyl -1H-benzimidazole-4-(N-6-purinyl)amide (1333)2- pyrazolyl -1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1334)2-(2'-pyridyl)-1H-benzimidazole-4- (N-2-hydroxyl-4-pyrimidinyl)amide (1335)2-(2'-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1336)2-(2'-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1337)2-(3'-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1338)2-(3'-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1339)2-(3'-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1340)2-(4'-pyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1341)2-(4'-pyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1342)2-(4'-pyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1343)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1344)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1345)2-(2'-imidazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1346)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1347)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1348)2-(4-methoxypyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1349)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1350)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-purinyl)amide; (1351)2-(4-dimethylaminopyridyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1352)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1353)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1354)2-(3-pyridazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1355)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrim idinyl)amide (1356)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-purinyl)amide 289 (1357)2-(2-N-methyl-4-N-methylpiperazinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1358)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1359)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1360)2-(2-pyrazinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1361)2-(4-methyl-5-aminothiazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1362)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1363)2-(4-methyl-5-aminothiazolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1364)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1365)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1366)2-(2-thiazolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1367)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1368)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1369)2-(5-thiazolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 370)2-(2-pyridyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1371)2-(2-pyridyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1 372)2-(2-pyridyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1373)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1 374)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1375)2-(2-phenyl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 376)2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1 377)2-(4-amino-6-chloro-5-pyrimidinyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1378)2-(4-amino-6-chloro-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1 379)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (13 80)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1381)2-(2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (13 82)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1383)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (13 84)2-(N-methyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1385)2-(3,5-dimethyl-2-pyrrolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (13 86)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide 290 (13 87)2-(3,5-dimethyl-2-pyrrolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (13 88)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (13 89)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1390)2-(2-quinolinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1391)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1392)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1393)2-(2-piperidinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1394)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1395)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-6-purinyl)amide (1396)2-(4-piperidinyl)- 1 H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1397)2-(3-indolyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1398)2-(3-indolyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1399)2-(3-indolyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1400)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1401)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1402)2-(2,3,4-trimethoxyphenyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1403)2-(3-hydroxyl-4-methoxyphenyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1404)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-6-purinyl)amide (1405)2-(3-hydroxyl-4-methoxyphenyl)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1406)2-(2-bromo-5-pyridine)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1407)2-(2-bromo-5-pyridine)-1H-benzimidazole-4- (N-6-purinyl)amide (1408)2-(2-bromo-5-pyridine)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1409)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1410)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-6-purinyl)amide (1411)2-(2-amino-3-pyridine)- 1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1412)2-(2-pyrrolidine- 1-yl-5-pyrimidinyl)- 1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidi nyl)amide (1413)2-(2-pyrrolidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1414)2-(2-pyrrolidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1415)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidin yl)amide 291 (1416)2-(2-piperidine-1- yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1417)2-(2-piperidine-1-yl-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1418)2-(2-cyclopropylamino)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimidinyl)amide (1419)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1420)2-(2-cyclopropylamino-5-pyrimidinyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1421)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-2-hydroxyl-4-pyrimi dinyl)amide (1422)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-purinyl)amide (1423)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide (1424)2-(1,3-dimethyl-5-chloro-4-pyrazolyl)-1H-benzimidazole-4-(N-6-hydroxyl-2-purinyl)amide.
7. The benzimidazole-4- carboxamide derivatives or a pharmaceutically acceptable salts thereof according to any one of claims 1 to 6, wherein the pharmaceutically acceptable salts of benzimidazole-4-carboxamide derivatives are inorganic acid salts thereof selected from sulfate, hydrochloride, nitrate, phosphate or boratethe, or organic acid salts thereof selected from citrate, succinate, tartrate, lactate or mesylate.
8. A pharmaceutical composition, comprising a therapeutically effective amount of the benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to any one of claims 1 - 7, and one or more pharmaceutically acceptable thinner, excipient and/ or inert carrier.
9. A use of benzimidazole-4-carboxamide derivatives or a pharmaceutically acceptable salts thereof according to any one of claims 1-7 for preparation of .antivirus medications.
10. The use according to claim 9, wherein the viruses comprising coxsackie virus, echovirus and enterovirus of Picornaviridae.
11. A method of preparing for benzimidazole-4-carboxamide derivatives or pharmaceutically acceptable salts thereof according to Formula (I) of any one of claims 1 7, comprisng the following steps: (1) 2-aminoacetyl-3-nitrobenzoic acid is undergoing reactions of ammonolysis, Hoffman degradation and reduction in turn, to produce 2,3- diamino benzoic acid. (2) 2,3-diamino benzoic acid is condensed with aldehydes X-CHO in the presence of catalyst of cupric acetate, to produce benzimidazole-4-carboxylic acid of Formula (II). 292 OOH 0 N N (3) benzimidazole-4-carboxylic acid is reacted with thionyl chloride to produce acyl chloride, and then condensing the acyl chloride and an amine NH 2 -Y, to produce the benzimidazole-4-carboxamide derivative of Formula (I). Y N-H 0 S N (I)
12. The method according to claim 11, wherein benzimidazole-4-carboxylic acid is reated with thionyl chloride at temperature of 0-80C in a molar molecular ratio of thionyl chloride to benzimidazole-4-carboxylic acid is 1-20 times, to produce benzimidazole-4-carbonyl chloride, and then benzimidazole-4-carbonyl chloride is reacted with an amine in an organic solvent at temperature of 0-100C to produce benzimidazole-4-carboxamide derivatives.
13. The method according to claim 12, wherein the organic solvent comprises dichloroethane, 1,1,2-trichloroethane, chloroform, tetrachloroethylene, benzene, toluene, xylene, chlorobenzene or dichlorobenzene.
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