CA2746495C - Anti-viral protection with viruses containing a defective genome - Google Patents

Anti-viral protection with viruses containing a defective genome Download PDF

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Publication number
CA2746495C
CA2746495C CA2746495A CA2746495A CA2746495C CA 2746495 C CA2746495 C CA 2746495C CA 2746495 A CA2746495 A CA 2746495A CA 2746495 A CA2746495 A CA 2746495A CA 2746495 C CA2746495 C CA 2746495C
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CA
Canada
Prior art keywords
virus
influenza
mice
interferon
infection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2746495A
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English (en)
French (fr)
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CA2746495A1 (en
Inventor
Nigel Dimmock
Andrew Easton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Warwick
Original Assignee
University of Warwick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Warwick filed Critical University of Warwick
Publication of CA2746495A1 publication Critical patent/CA2746495A1/en
Application granted granted Critical
Publication of CA2746495C publication Critical patent/CA2746495C/en
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
    • C12N2760/16162—Methods of inactivation or attenuation by genetic engineering

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA2746495A 2008-12-12 2009-12-08 Anti-viral protection with viruses containing a defective genome Active CA2746495C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0822672.2 2008-12-12
GBGB0822672.2A GB0822672D0 (en) 2008-12-12 2008-12-12 Anti-viral protection with viruses containing a defective genome
PCT/GB2009/051666 WO2010067109A1 (en) 2008-12-12 2009-12-08 Anti-viral protection with viruses containing defective genome segments

Publications (2)

Publication Number Publication Date
CA2746495A1 CA2746495A1 (en) 2010-06-17
CA2746495C true CA2746495C (en) 2018-04-17

Family

ID=40325992

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2746495A Active CA2746495C (en) 2008-12-12 2009-12-08 Anti-viral protection with viruses containing a defective genome

Country Status (11)

Country Link
US (1) US8691215B2 (enExample)
EP (1) EP2355834B1 (enExample)
CN (1) CN102256611B (enExample)
AU (1) AU2009326204B2 (enExample)
CA (1) CA2746495C (enExample)
DK (1) DK2355834T3 (enExample)
ES (1) ES2423193T3 (enExample)
GB (1) GB0822672D0 (enExample)
IN (1) IN2011KN02819A (enExample)
PL (1) PL2355834T3 (enExample)
WO (1) WO2010067109A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2019685B1 (en) * 2006-05-24 2014-11-12 The University Of Warwick Defective interfering virus
GB2522615A (en) * 2014-01-16 2015-08-05 Univ Warwick Assay and medicament
WO2019206285A1 (en) * 2018-04-26 2019-10-31 The University Of Hong Kong Nucleic acid molecules and dual-functional peptides having antiviral activity and delivery activity, compositions and methods thereof
GB202209861D0 (en) * 2022-07-05 2022-08-17 Univ Court Univ St Andrews Viral vectors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8715940B2 (en) 1999-04-06 2014-05-06 Wisconsin Alumni Research Foundation Method of making recombinant influenza virus
CN102302773B (zh) 2004-10-06 2014-05-14 米迪缪尼有限公司 冷藏温度稳定的流感疫苗组合物
JP4986859B2 (ja) 2004-11-11 2012-07-25 アボツト・バイオロジカルズ・ベー・ブイ 欠陥インフルエンザウイルス粒子
EP2019685B1 (en) 2006-05-24 2014-11-12 The University Of Warwick Defective interfering virus
GB2437799B (en) * 2006-05-24 2008-08-13 Univ Warwick Defective interfering virus

Also Published As

Publication number Publication date
DK2355834T3 (da) 2013-07-29
EP2355834B1 (en) 2013-05-01
IN2011KN02819A (enExample) 2015-07-10
CA2746495A1 (en) 2010-06-17
AU2009326204B2 (en) 2014-01-09
ES2423193T3 (es) 2013-09-18
US8691215B2 (en) 2014-04-08
WO2010067109A1 (en) 2010-06-17
CN102256611A (zh) 2011-11-23
CN102256611B (zh) 2014-05-21
GB0822672D0 (en) 2009-01-21
US20110243896A1 (en) 2011-10-06
AU2009326204A1 (en) 2011-06-23
PL2355834T3 (pl) 2014-03-31
EP2355834A1 (en) 2011-08-17

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Effective date: 20141203