CA2744703A1 - Imagerie moleculaire tridimensionnelle par spectrometrie de masse a ionisation par electronebulisation a ablation infrarouge par laser - Google Patents

Imagerie moleculaire tridimensionnelle par spectrometrie de masse a ionisation par electronebulisation a ablation infrarouge par laser Download PDF

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Publication number
CA2744703A1
CA2744703A1 CA2744703A CA2744703A CA2744703A1 CA 2744703 A1 CA2744703 A1 CA 2744703A1 CA 2744703 A CA2744703 A CA 2744703A CA 2744703 A CA2744703 A CA 2744703A CA 2744703 A1 CA2744703 A1 CA 2744703A1
Authority
CA
Canada
Prior art keywords
sample
laesi
ions
imaging
mass spectrometry
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2744703A
Other languages
English (en)
Inventor
Akos Vertes
Peter Nemes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
George Washington University
Original Assignee
George Washington University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/323,276 external-priority patent/US7964843B2/en
Application filed by George Washington University filed Critical George Washington University
Publication of CA2744703A1 publication Critical patent/CA2744703A1/fr
Abandoned legal-status Critical Current

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/14—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/145—Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0004—Imaging particle spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step

Landscapes

  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Electron Tubes For Measurement (AREA)
  • Sampling And Sample Adjustment (AREA)
CA2744703A 2008-11-25 2009-11-25 Imagerie moleculaire tridimensionnelle par spectrometrie de masse a ionisation par electronebulisation a ablation infrarouge par laser Abandoned CA2744703A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/323,276 2008-11-25
US12/323,276 US7964843B2 (en) 2008-07-18 2008-11-25 Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry
US26411909P 2009-11-24 2009-11-24
US61/264,119 2009-11-24
PCT/US2009/065891 WO2010068491A2 (fr) 2008-11-25 2009-11-25 Imagerie moléculaire tridimensionnelle par spectrométrie de masse à ionisation par électronébulisation à ablation infrarouge par laser

Publications (1)

Publication Number Publication Date
CA2744703A1 true CA2744703A1 (fr) 2010-06-17

Family

ID=42243279

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2744703A Abandoned CA2744703A1 (fr) 2008-11-25 2009-11-25 Imagerie moleculaire tridimensionnelle par spectrometrie de masse a ionisation par electronebulisation a ablation infrarouge par laser

Country Status (4)

Country Link
EP (2) EP2660848A1 (fr)
JP (1) JP2012510062A (fr)
CA (1) CA2744703A1 (fr)
WO (1) WO2010068491A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102590089A (zh) * 2012-01-13 2012-07-18 浙江大学 室内光谱观测三维载物台及其应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2603679B (en) * 2019-11-27 2023-09-20 Thermo Fisher Scient Bremen Gmbh Systems and methods for imaging and ablating a sample
WO2022080412A1 (fr) * 2020-10-13 2022-04-21 花王株式会社 Procédé de prévision de rendement de blé
WO2023037536A1 (fr) * 2021-09-13 2023-03-16 株式会社島津製作所 Spectromètre de masse

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10310518A1 (de) * 2003-03-09 2004-10-14 TransMIT Gesellschaft für Technologietransfer mbH Dreidimensionale Abbildung der chemischen Oberflächenzusammensetzung von Objekten
WO2005001869A2 (fr) * 2003-06-06 2005-01-06 Ionwerks Implantation ou depot dans l'or d'echantillons biologiques destines au profilage tridimensionnel en epaisseur de tissus par desorption laser
WO2005065307A2 (fr) * 2003-12-31 2005-07-21 Ionwerks, Inc. Spectrometrie de masse maldi par tof orthogonal/mobilite ionique a detection simultanee de mode positif et negatif
WO2005095942A1 (fr) * 2004-03-30 2005-10-13 Riken Méthode d’analyse de biopsie par ablation au laser et appareil utilisant celle-ci
US7335897B2 (en) * 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
US8067730B2 (en) * 2007-07-20 2011-11-29 The George Washington University Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102590089A (zh) * 2012-01-13 2012-07-18 浙江大学 室内光谱观测三维载物台及其应用

Also Published As

Publication number Publication date
WO2010068491A2 (fr) 2010-06-17
WO2010068491A3 (fr) 2010-08-26
EP2356668A2 (fr) 2011-08-17
EP2660848A1 (fr) 2013-11-06
EP2356668B1 (fr) 2013-07-17
JP2012510062A (ja) 2012-04-26
EP2356668A4 (fr) 2012-05-30

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20141119

FZDE Discontinued

Effective date: 20170824