CA2737489A1 - Composite animal litter material and methods - Google Patents
Composite animal litter material and methods Download PDFInfo
- Publication number
- CA2737489A1 CA2737489A1 CA2737489A CA2737489A CA2737489A1 CA 2737489 A1 CA2737489 A1 CA 2737489A1 CA 2737489 A CA2737489 A CA 2737489A CA 2737489 A CA2737489 A CA 2737489A CA 2737489 A1 CA2737489 A1 CA 2737489A1
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- Prior art keywords
- composite material
- solid matrix
- chromogenic
- composite
- oxidizing agent
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
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- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A composite litter material for detecting a disease, such as urinary tract disease, when contacted by fe-line urine includes an absorptive polymer material forming a solid matrix, exfoliated clay embedded and dispersed within the solid matrix, a chromogenic indicator provided within the solid matrix, and an oxidizing agent distributed and stabilized within the solid matrix to be responsive to peroxidase activity in the urine to activate the chromogenic indicator. A method for detecting or diagnosing a feline disease includes contacting urine with the material and de-tecting a color change. A method of manufacturing the composite material includes preparing a mixture compris-ing the absorptive polymer and water and distributing the exfoliated clay, chromogenic indicator and oxidizing agent within the mixture, preferably by extrusion and addition of the components at particular points in processing the polymer mixture.
Claims (47)
1. A composite litter material for detecting a disease when contacted by feline urine, the composite litter material comprising:
an absorptive polymer material forming a solid matrix;
exfoliated clay embedded and dispersed within the solid matrix;
a chromogenic indicator provided within the solid matrix; and an oxidizing agent distributed and stabilized within the solid matrix such that the oxidizing agent is available and responsive to peroxidase or pseudoperoxidase activity in the urine to activate the chromogenic indicator.
an absorptive polymer material forming a solid matrix;
exfoliated clay embedded and dispersed within the solid matrix;
a chromogenic indicator provided within the solid matrix; and an oxidizing agent distributed and stabilized within the solid matrix such that the oxidizing agent is available and responsive to peroxidase or pseudoperoxidase activity in the urine to activate the chromogenic indicator.
2. The composite material of claim 1, wherein the absorptive polymer material is a polysaccharide.
3. The composite material of claim 2, wherein the polysaccharide comprises alpha-linkages.
4. The composite material of claim 1, wherein the exfoliated clay comprises exfoliated phyllosilicates.
5. The composite material of claim 4, wherein the exfoliated phyllosilicates are dispersed throughout the entire solid matrix.
6. The composite material of claim 1, wherein the chromogenic indicator is cationic and the exfoliated clay comprises sheets having anionic surface characteristics.
7. The composite material of claim 1, wherein the chromogenic indicator is a benzidine-based compound.
8. The composite material of claim 7, wherein the chromogenic indicator corresponds to the following formula:
wherein R1, R2, R3 and R4 are the same or different and represent hydrogen, halogen, a lower alkyl or alkoxy group containing 1 to 4 carbon atoms, a (C1 -C4)-dialkylamino group, an acetylamino group, a nitro group or an aromatic group which may be substituted; and wherein R5 and R6 are the same or different and represent water-soluble groups, hydroxyl group, amino group, acidic group, disulfonyl group, ether group, halogen, and a lower alkyl or alkoxy group containing 1 to 4 carbon atoms, a (C1 -C4)-dialkylamino group, an acetylamino group or a nitro group.
wherein R1, R2, R3 and R4 are the same or different and represent hydrogen, halogen, a lower alkyl or alkoxy group containing 1 to 4 carbon atoms, a (C1 -C4)-dialkylamino group, an acetylamino group, a nitro group or an aromatic group which may be substituted; and wherein R5 and R6 are the same or different and represent water-soluble groups, hydroxyl group, amino group, acidic group, disulfonyl group, ether group, halogen, and a lower alkyl or alkoxy group containing 1 to 4 carbon atoms, a (C1 -C4)-dialkylamino group, an acetylamino group or a nitro group.
9. The composite material of claim 1, wherein the chromogenic indicator is 3,3',5,5'-tetramethylbenzidine (TMB).
10. The composite material of claim 1, wherein the chromogenic indicator is 3,3',5,5' tetramethylbenzidine dihydrochloride (TMB-HC).
11. The composite material of claim 1, wherein the oxidizing agent is a hydroperoxide.
12. The composite material of claim 11, wherein the oxidizing agent is cumene hydroperoxide.
13. The composite material of claim 11, wherein the oxidizing agent is diisopropylbenzene dihydroperoxide.
14. The composite material of claim 11, wherein the absorptive polymer material comprises polyols having polymer backbones and the hydroperoxide is stabilized along the polymer backbones.
15. The composite material of claim 1, having the form of discrete pellets.
16. The composite material of claim 15, wherein each pellet has a disk shape, a lozenge shape, a wafer shape or a cat head shape.
17. The composite material of claim 15, wherein each pellet has a diameter between about 1 mm to about 10 mm and a thickness between about 0.5 mm and about 3 mm.
18. The composite material of claim 1, further comprising an impregnated stabilizer composition.
19. The composite pellets of claim 1, wherein the stabilizer composition comprises a color enhancer.
20. A cat litter for detecting a feline disease when contacted by feline urine, the cat litter comprising:
a particulate filler material;
composite pellets mixable with the particulate filler material, each of the composite pellets comprising:
an absorptive polymer material forming a solid matrix;
exfoliated clay embedded and dispersed within the solid matrix;
a chromogenic indicator provided within the solid matrix; and an oxidizing agent distributed and stabilized within the solid matrix such that the oxidizing agent is available and responsive to peroxidase or pseudoperoxidase activity in the urine to activate the chromogenic indicator.
a particulate filler material;
composite pellets mixable with the particulate filler material, each of the composite pellets comprising:
an absorptive polymer material forming a solid matrix;
exfoliated clay embedded and dispersed within the solid matrix;
a chromogenic indicator provided within the solid matrix; and an oxidizing agent distributed and stabilized within the solid matrix such that the oxidizing agent is available and responsive to peroxidase or pseudoperoxidase activity in the urine to activate the chromogenic indicator.
21. The cat litter of claim 20, wherein the particulate litter material comprises clumping or non-clumping clay.
22. The cat litter of claim 20, wherein the particulate litter material and the composite pellets are sized and mixed to as to form a substantially homogeneous mixture.
23. A method for detecting or diagnosing a feline disease, the method comprising:
allowing urine to contact a composite material comprising an absorptive polymer material forming a solid matrix, exfoliated clay embedded and dispersed within the solid matrix, a chromogenic indicator provided within the solid matrix and an oxidizing agent distributed and stabilized within the solid matrix such that the oxidizing agent is available and responsive to peroxidase or pseudoperoxidase activity in the urine to activate the chromogenic indicator;
detecting or diagnosing the feline disease by determining whether the chromogenic indicator has been activated as evidenced by a color change.
allowing urine to contact a composite material comprising an absorptive polymer material forming a solid matrix, exfoliated clay embedded and dispersed within the solid matrix, a chromogenic indicator provided within the solid matrix and an oxidizing agent distributed and stabilized within the solid matrix such that the oxidizing agent is available and responsive to peroxidase or pseudoperoxidase activity in the urine to activate the chromogenic indicator;
detecting or diagnosing the feline disease by determining whether the chromogenic indicator has been activated as evidenced by a color change.
24. The method of claim 23, comprising providing the composite material pre-mixed with a conventional cat litter material and allowing a cat to urinate thereon.
25. The method of claim 23, comprising providing the composite material as part of a testing kit.
26. A method of manufacturing a composite animal litter material for detecting a feline disease, comprising:
preparing a mixture comprising an absorptive polymer and water;
distributing exfoliated clay, a chromogenic indicator and an oxidizing agent to within the mixture to produce the composite animal litter material.
preparing a mixture comprising an absorptive polymer and water;
distributing exfoliated clay, a chromogenic indicator and an oxidizing agent to within the mixture to produce the composite animal litter material.
27. The method of claim 26, wherein a solution comprising the exfoliated clay is added to the mixture during the preparation thereof.
28. The method of claim 27, wherein a chromogenic solution comprising the chromogenic indicator, a solvent and the oxidizing agent is prepared and introduced into the mixture.
29. The method of claim 28, wherein the chromogenic solution and the mixture are combined by extrusion, pressure agglomeration, tumble growth agglomeration or matrix melt formation, or a combination thereof.
30. The method of claim 28, wherein the chromogenic solution is buffered at a pH
between about 1.5 and about 7.
between about 1.5 and about 7.
31. The method of claim 30, wherein the chromogenic solution is buffered at a pH
allowing solubility in the absence of alcohol.
allowing solubility in the absence of alcohol.
32. The method of claim 28, wherein the chromogenic solution and the mixture are combined by extrusion.
33. The method of claim 32, comprising:
providing an extrusion apparatus having an upstream section, a mid section and a downstream section;
feeding the mixture into the upstream section of the extrusion apparatus;
feeding the chromogenic solution into the mixture at the downstream section of the extrusion apparatus, to form a combined blend;
extruding, cutting and drying the combined blend to form the composite material.
providing an extrusion apparatus having an upstream section, a mid section and a downstream section;
feeding the mixture into the upstream section of the extrusion apparatus;
feeding the chromogenic solution into the mixture at the downstream section of the extrusion apparatus, to form a combined blend;
extruding, cutting and drying the combined blend to form the composite material.
34. The method of claim 33, wherein the mid section is operated at a higher temperature than the upstream and downstream sections.
35. The method of claim 33, wherein the temperature of the mid section is about 60 to about 80°C higher than either one of the upstream or downstream sections.
36. The method of claim 33, wherein the upstream section is operated at a temperature between about 25 °C and about 40°C, the mid section is operated at a temperature between about 80°C and about 130°C, and the downstream section is operated at a temperature between about 25 °C and about 40°C.
37. The method of claim 36, wherein the upstream section is operated at a temperature of about 30°C, the mid section is operated at a temperature of about 110 °C, and the downstream section is operated at a temperature of about 40°C.
38. The method of claim 33, comprising homogenizing the combined blend.
39. The method of claim 33, wherein the extrusion apparatus comprises a twin screw extruder.
40. The method of claim 33, wherein the extrusion apparatus comprises a first extruder having an inlet and an outlet, and a second extruder coupled to the first extruder to receive the combined blend from the outlet of the first extruder.
41. The method of claim 40, wherein the first extruder is a twin-screw extruder.
42. The method of claim 41, wherein the second extruder is a single screw extruder.
43. The method of claim 33, wherein the pH of the chromogenic solution is acidic.
44. The method of claim 33, wherein the chromogenic solution further comprises an amount of alcohol sufficient for solubilization.
45. The method of claim 33, wherein the exfoliated clay is exfoliated bentonite and is added at less than 1% w/w with respect to the mixture.
46. The method of claim 33, wherein the absorptive polymer is wheat starch or corn starch.
47. The method of claim 28, wherein the combined blend, after exiting the extruder, is dried at about 50°C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2737489A CA2737489C (en) | 2009-05-22 | 2010-05-21 | Composite animal litter material and methods |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA61/180,635 | 2009-05-22 | ||
| CA18063509 | 2009-05-22 | ||
| CA2737489A CA2737489C (en) | 2009-05-22 | 2010-05-21 | Composite animal litter material and methods |
| PCT/CA2010/000789 WO2010133001A1 (en) | 2009-05-22 | 2010-05-21 | Composite animal litter material and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2737489A1 true CA2737489A1 (en) | 2010-11-25 |
| CA2737489C CA2737489C (en) | 2012-01-24 |
Family
ID=43971820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2737489A Active CA2737489C (en) | 2009-05-22 | 2010-05-21 | Composite animal litter material and methods |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2737489C (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014032175A1 (en) * | 2012-08-29 | 2014-03-06 | 7905122 Canada Inc. | Chromogenic absorbent material for animal litter and related chromogenic solution |
| US10175231B2 (en) | 2014-02-27 | 2019-01-08 | 7905122 Canada Inc. | Chromogenic absorbent material for animal litter |
| US10583420B2 (en) | 2014-10-01 | 2020-03-10 | 7905122 Canada Inc. | Process and apparatus for manufacturing water-absorbing material and use in cat litter |
| CN112715385A (en) * | 2020-12-30 | 2021-04-30 | 青岛美今生物科技有限公司 | Preparation method of functional color-developing health indication plant deodorizing cat litter |
| US11013823B2 (en) | 2016-04-01 | 2021-05-25 | 7905122 Canada Inc. | Water-absorbing material and uses thereof |
-
2010
- 2010-05-21 CA CA2737489A patent/CA2737489C/en active Active
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014032175A1 (en) * | 2012-08-29 | 2014-03-06 | 7905122 Canada Inc. | Chromogenic absorbent material for animal litter and related chromogenic solution |
| US9547000B2 (en) | 2012-08-29 | 2017-01-17 | 7905122 Canada Inc. | Chromogenic absorbent material for animal litter and related chromogenic solution |
| US10175231B2 (en) | 2014-02-27 | 2019-01-08 | 7905122 Canada Inc. | Chromogenic absorbent material for animal litter |
| US10908150B2 (en) | 2014-02-27 | 2021-02-02 | 7905122 Canada Inc. | Chromogenic absorbent material for animal litter |
| US10583420B2 (en) | 2014-10-01 | 2020-03-10 | 7905122 Canada Inc. | Process and apparatus for manufacturing water-absorbing material and use in cat litter |
| CN111701573A (en) * | 2014-10-01 | 2020-09-25 | 7905122加拿大股份有限公司 | Method and device for producing water-absorbing material and use in cat litter |
| US11167265B2 (en) | 2014-10-01 | 2021-11-09 | 7905122 Canada Inc. | Process and apparatus for manufacturing water-absorbing material and use in cat litter |
| CN111701573B (en) * | 2014-10-01 | 2023-06-02 | 7905122加拿大股份有限公司 | Method and device for producing water-absorbing material and use in cat litter |
| US11013823B2 (en) | 2016-04-01 | 2021-05-25 | 7905122 Canada Inc. | Water-absorbing material and uses thereof |
| CN112715385A (en) * | 2020-12-30 | 2021-04-30 | 青岛美今生物科技有限公司 | Preparation method of functional color-developing health indication plant deodorizing cat litter |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2737489C (en) | 2012-01-24 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |