CA2737135C - Methods and kits for treating cluster headache disorders - Google Patents

Methods and kits for treating cluster headache disorders Download PDF

Info

Publication number
CA2737135C
CA2737135C CA2737135A CA2737135A CA2737135C CA 2737135 C CA2737135 C CA 2737135C CA 2737135 A CA2737135 A CA 2737135A CA 2737135 A CA2737135 A CA 2737135A CA 2737135 C CA2737135 C CA 2737135C
Authority
CA
Canada
Prior art keywords
cluster headache
subject
pharmaceutically acceptable
acceptable salt
acid diethylamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2737135A
Other languages
English (en)
French (fr)
Other versions
CA2737135A1 (en
Inventor
John H. Halpern
Torsten Harry Johannes Passie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medizinische Hochschule Hannover
Mclean Hospital Corp
Original Assignee
Medizinische Hochschule Hannover
Mclean Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medizinische Hochschule Hannover, Mclean Hospital Corp filed Critical Medizinische Hochschule Hannover
Publication of CA2737135A1 publication Critical patent/CA2737135A1/en
Application granted granted Critical
Publication of CA2737135C publication Critical patent/CA2737135C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2737135A 2008-09-17 2009-09-04 Methods and kits for treating cluster headache disorders Active CA2737135C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9777308P 2008-09-17 2008-09-17
US61/097,773 2008-09-17
PCT/US2009/055971 WO2010033392A2 (en) 2008-09-17 2009-09-04 Methods and kits for treating cluster headache disorders

Publications (2)

Publication Number Publication Date
CA2737135A1 CA2737135A1 (en) 2010-03-25
CA2737135C true CA2737135C (en) 2017-07-11

Family

ID=42040074

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2737135A Active CA2737135C (en) 2008-09-17 2009-09-04 Methods and kits for treating cluster headache disorders

Country Status (10)

Country Link
US (2) US8415371B2 (enExample)
EP (1) EP2331100B1 (enExample)
JP (1) JP5690732B2 (enExample)
CN (1) CN102164603B (enExample)
BR (1) BRPI0918623A2 (enExample)
CA (1) CA2737135C (enExample)
GB (1) GB2475660B (enExample)
IL (1) IL211714A (enExample)
MX (1) MX2011002883A (enExample)
WO (1) WO2010033392A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8859579B2 (en) 2008-03-21 2014-10-14 Richard Andrew Sewell Compostions and methods for preventing and/or treating disorders associated with cephalic pain
CN102164603B (zh) * 2008-09-17 2015-11-25 麦克莱恩医院 用于治疗丛集性头痛症的方法和试剂盒
EP4230195A1 (en) * 2019-03-07 2023-08-23 Arbormentis LLC Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic / psychotomimetic dosages and formulations
WO2021195427A1 (en) * 2020-03-25 2021-09-30 Ch Tac, Llc 2-bromo-lysergic acid diethylamide for substance abuse
WO2022133604A1 (en) * 2020-12-22 2022-06-30 Betterlife Pharma Inc. Methods of treating mental or mood disorders using 2-bromo-lsd
US20240180894A1 (en) * 2021-03-22 2024-06-06 Betterlife Pharma Inc. Methods of treating mental and/or mood disorders using 2-bromo-lsd alone or in combination with a mtor inhibitor
EP4329759A4 (en) 2021-04-30 2025-07-16 Mind Medicine Inc CRYSTALLINE FORMS OF LSD SALTS
EP4387624A4 (en) 2021-08-19 2025-07-30 Mind Medicine Inc Immediate Release Formulations of Diethylamide of D-Lysergic Acid for Therapeutical Applications
IL311602A (en) * 2021-09-20 2024-05-01 Betterlife Pharma Inc Lsd derivatives, synthesis & method for treatment of diseases and disorders
EP4630418B1 (en) * 2022-12-31 2026-03-18 Ceruvia Lifesciences LLC Salts of 2-bromolysergic acid diethylamide
WO2024145604A2 (en) * 2022-12-31 2024-07-04 Ceruvia Lifesciences Llc Process for synthesizing 2-bromolysergic acid diethylamide via controlled hydrolysis of bromocriptine
US20240228479A1 (en) 2022-12-31 2024-07-11 Ceruvia Lifesciences Llc Process for synthesizing 2-bromolysergic acid diethylamide via controlled bromination of lysergic acid

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3228959A (en) * 1962-01-16 1966-01-11 Geigy Chem Corp Quaternary salts of certain indolealkylamines and therapeutic uses thereof
US4524072A (en) * 1984-06-18 1985-06-18 Zivin Justin A Reduction of stroke damage
GB8618700D0 (en) * 1986-07-31 1986-09-10 Beecham Group Plc Compounds
EP0255297B1 (en) * 1986-07-31 1993-04-21 Beecham Group Plc Azabicyclic compounds, process for their preparation, and their pharmaceutical use
EP1478400A1 (en) * 2002-02-26 2004-11-24 Ortho-McNeil Pharmaceutical, Inc. Therapy for the treatment of migraine comprising anticonvulsant derivatives and antimigraine agents
WO2004112723A2 (en) 2003-06-20 2004-12-29 Ronald Aung-Din Tropical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
US8859579B2 (en) * 2008-03-21 2014-10-14 Richard Andrew Sewell Compostions and methods for preventing and/or treating disorders associated with cephalic pain
CN102164603B (zh) * 2008-09-17 2015-11-25 麦克莱恩医院 用于治疗丛集性头痛症的方法和试剂盒

Also Published As

Publication number Publication date
US20110104275A1 (en) 2011-05-05
JP2012502909A (ja) 2012-02-02
CN102164603B (zh) 2015-11-25
MX2011002883A (es) 2011-04-21
EP2331100A2 (en) 2011-06-15
US20130252996A1 (en) 2013-09-26
HK1161098A1 (zh) 2012-08-24
GB201104907D0 (en) 2011-05-04
CA2737135A1 (en) 2010-03-25
CN102164603A (zh) 2011-08-24
EP2331100A4 (en) 2012-04-25
GB2475660A (en) 2011-05-25
WO2010033392A2 (en) 2010-03-25
GB2475660B (en) 2013-04-17
BRPI0918623A2 (pt) 2015-12-01
US8415371B2 (en) 2013-04-09
WO2010033392A3 (en) 2010-06-17
JP5690732B2 (ja) 2015-03-25
EP2331100B1 (en) 2014-07-16
IL211714A (en) 2016-04-21
IL211714A0 (en) 2011-06-30

Similar Documents

Publication Publication Date Title
CA2737135C (en) Methods and kits for treating cluster headache disorders
KR102682159B1 (ko) 수면 무호흡을 치료하기 위한 방법 및 조성물
US11033543B2 (en) Methods of providing weight loss therapy in patients with major depression
CA3075719A1 (en) Synthetic transdermal cannabidiol for the treatment of focal epilepsy in adults
HK1161098B (en) Methods and kits for treating cluster headche disorders
JP2007513056A (ja) 糖尿病性神経因性疼痛の処置および睡眠の改善のためのオキシカルバゼピンの使用
US11826326B2 (en) Benzoic acid or a salt and derivative thereof for use in preventing or treating depression
JP5042425B2 (ja) 機能性胃腸疾患治療用トラマドール
Casaer et al. Risperidone in the treatment of childhood autistic disorder: an open pilot study
WO2025137348A1 (en) Cyclobenzaprine hcl for use in treating fibromyalgia with early onset response and favorable tolerability and side effect profile
Mutalik et al. Evidence Based Management of Bipolar Depression
US20120172390A1 (en) Method of treating sleep disorders using the combination of eplivanserin and zolpidem

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140903

MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 15TH ANNIV.) - STANDARD

Year of fee payment: 15

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20240830

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT

Effective date: 20240830