CA2733446A1 - Easy linking device with retractable protector - Google Patents

Easy linking device with retractable protector Download PDF

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Publication number
CA2733446A1
CA2733446A1 CA2733446A CA2733446A CA2733446A1 CA 2733446 A1 CA2733446 A1 CA 2733446A1 CA 2733446 A CA2733446 A CA 2733446A CA 2733446 A CA2733446 A CA 2733446A CA 2733446 A1 CA2733446 A1 CA 2733446A1
Authority
CA
Canada
Prior art keywords
vial
syringe
transfer device
figures
view
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2733446A
Other languages
French (fr)
Inventor
David L. Reynolds
Daniel Macdonald
Yan Tremblay
Eric Geoffroy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duoject Medical Systems Inc
Original Assignee
Duoject Medical Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duoject Medical Systems Inc filed Critical Duoject Medical Systems Inc
Priority to CA2733446A priority Critical patent/CA2733446A1/en
Priority to JP2013556940A priority patent/JP2014511249A/en
Priority to AU2012225163A priority patent/AU2012225163B2/en
Priority to EP12754579.6A priority patent/EP2680807B1/en
Priority to CA2827993A priority patent/CA2827993C/en
Priority to US13/261,729 priority patent/US9381135B2/en
Priority to PCT/CA2012/000190 priority patent/WO2012119225A1/en
Priority to ES12754579.6T priority patent/ES2593266T3/en
Priority to CN201280020984.9A priority patent/CN103501751B/en
Publication of CA2733446A1 publication Critical patent/CA2733446A1/en
Priority to JP2017062340A priority patent/JP6502412B2/en
Priority to JP2018234525A priority patent/JP6676740B2/en
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096Combination of a vial and a syringe for transferring or mixing their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14Details; Accessories therefor
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048Connecting means
    • A61J1/2055Connecting means having gripping means

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Description

EASY LINKING DEVICE WITH
RETRACTABLE PROTECTOR
FIELD OF THE INVENTION

The present invention relates to a transfer system and more particularly, relates to an assembly for transferring one or more components of a pharmaceutical composition between containers.

BACKGROUND OF THE INVENTION

Typically, a syringe is filled manually by aspirating a liquid pharmaceutical component from a pharmaceutical vial which traditionally has a penetrable closure. The syringe has a needle that penetrates the penetrable closure following which the syringe is typically filled by drawing air into the body of the syringe, aligning the needle with the vial's penetrable closure and inserting the needle through the penetrable closure into the vial.
Subsequently, the vial is inverted and air is forced from the body of the syringe into the vial.
The plunger is then withdrawn to draw out the desired volume of the pharmaceutical component into the syringe and the needle is removed from the vial.

Many pharmaceutical preparations must be distributed and sold as two or more separate components - typically a solid component and a liquid component. They are mixed just prior to administration. In some instances, the two or more components may each be liquid and require mixing prior to administration to the patient.

SUMMARY OF THE INVENTION

It is an object of the present invention to provide an assembly for transferring the contents of a first container to a second container.

In a large number of cases, the transfer device of the present invention provides for the easy linking of a vial and a syringe whereby the components may be mixed to form a -I-composition in the syringe ready for patient injection.

The contents of the vial may be any suitable pharmaceutical component though in many instances, it will be a dry pharmaceutical component such as a lyophilized product.
However, as previously mentioned, it could also be a liquid component.

The syringe will normally contain a liquid component which is frequently a diluent for the active pharmaceutical ingredient in the vial. The syringe may be any conventional syringe readily available from different manufacturers. Typically, the syringe will contain a piston and have a vac stop or finger flange attached to one end thereof. A
plunger rod will be attachable to the piston of the syringe.

One problem with known transfer devices is that access to the needle or plastic spike within the transfer device should be minimized to prevent accidental pricks.
Once such transfer device is shown in International Application PCT/CA2010/001399, the teachings of which are incorporated herein by reference. In the transfer device, a cap is provided to permit access to the syringe side of the device and the luer connection cannot be accessed until the cap is removed. However, the cap can only be removed when the device is coupled to the vial.

On some occasions, it is deemed desirable to re-use the transfer device. With the aforementioned transfer device, this was not possible as the vial remains secured to the transfer device and both are disposed of as a unit.

BRIEF DESCRIPTION OF THE DRAWINGS

Having thus generally described the invention, reference will be made to the accompanying drawings illustrating an embodiment thereof, in which:

Figure 1 is a side elevational view of a transfer device according to the present
-2-invention;

Figure 2 is a side elevational view, partially in section, of a vial containing a medicant;

Figure 3 is a side elevational view of a syringe and plunger rod;

Figure 4 is a cross sectional view of the transfer device prior to its use;
Figure 5A is a side elevational view of the device being placed on a vial;
Figure 5B is a side elevational view thereof;

Figure 6A is a side elevational view showing displacement of the cap;
Figure 6B is a cross sectional view illustrating the cap being ejected;

Figure 7 is a view, partially in cross section, of a syringe being attached to the transfer device;

Figure 8 is a view similar to Figure 7A illustrating the mixing of components;
Figure 9 is a view, partially in section, illustrating the aspiration of the mixture into the syringe;

Figure 10 is an exploded view, partially in cutaway, of the components of the transfer device;

Figure 11 is a cross sectional view illustrating placement of the transfer device on the top of a vial, this view being rotated 90 from the view of Figure 5B;

Figure 12 is a cross sectional view similar to Figure 11 illustrating the piercing of the septum of the vial and commencement of the removal of the cap;

Figure 13 is a cross sectional view similar to Figures 11 and 12 illustrating removal of the cap.

Figure 14 illustrates a further embodiment wherein the piercing member is a spike;
-3-Figure 15 illustrates a variation thereof wherein the spike has a vent formed therein;
Figure 16 illustrates a modified inner body member;

Figure 17 is a cross sectional view thereof;

Figures 18A to 18J illustrate sequential operation of a transfer device according to an embodiment of the present invention; and Figures 19A to 19H illustrate the operation of a further embodiment of a transfer device.

DETAILED DESCRIPTION OF THE INVENTION

Referring to the drawings in greater detail and by reference characters thereto, there is illustrated a transfer system which is generally designated by reference numeral 10 and which is suitable for use with a vial generally designated by reference numeral 12.

Vial 12 has a body 14 with a neck sealed by a septum 16 over which there is a cap 18.
A medicant 20 is provided in body 14 and would typically comprise a dry ingredient although a fluid may also be utilized.

Transfer system 10 includes an outer housing 24 having finger grip depressions 25 on opposed sides. An inner body 26 is connected to outer housing 24 by means of a lower horizontal wall 30 which extends between housing 24 and inner body 26. Lower horizontal wall 30 is not continuous, but rather is arranged so that there are a pair of opposed openings or channels 29 which extend through lower horizontal wall 30. Inner body 26 is also provided with a luer connector 28 at an upper portion thereof.

Extending downwardly from lower horizontal wall 30 are a pair of legs 32 each of which has a lower tapered end 34. A latch 36 is also provided on legs 32 for reasons which will be come apparent hereinbelow. Formed on an inner face of each latch 36 is a recess 37.
-4-Transfer system 10 also includes a plurality of ribs 38 on the inner side of housing 24 which define channels 29.

A pusher element 44 has a base 46 and a pair of upwardly extending legs 48. A
lower portion of upwardly extending legs 48 has an inwardly extending element 50 which preferably terminates in a cruciform configuration 51.

Transfer system 10 also includes a cover 54 which has a top wall 56 and a pair of downwardly extending side walls 58. A pair of slots 60 separate side walls 58 to provide a desired flexibility. On the outside of each side wall 58 there is provided a rib 62. Top wall 56 of cover 54 includes a slight overhang 64.

Transfer system 10 further includes a needle 66 having a piercing tip 68 retained in inner body 26. Needle 66 may be replaced by a spike.

In operation, transfer system 10 is placed on top of vial 12 as shown in Figures 5A
and 11 with a finger or thumb engaging depression 25. Transfer system 10 is then moved downwardly as shown in Figures 6B, 12 and 13. In moving upwardly, the lower tapered ends 34 of legs 32 engage the cap 18 of vial 12 and force the legs outwardly.
This allows release of base 46 of pusher element 44. Continued movement will cause latches 36 to engage the neck of vial 12. This upward movement causes a piercing of septum 16 by piercing tip 68 of needle 66 to thereby reduce any vacuum therein. The upward movement also results in elements 50 of pusher member 44 moving upwardly to engage the bottom edge of side walls 58 of cover 54 to move the same upwardly. This then permits the removal of cover 54 and access to the contents 20 of vial 12.

The transfer system is preferably utilized with a syringe such as shown in Figures 3 and 4. The syringe includes a syringe body 74 having a plunger 76 mounted therein. A
-5-plunger rod 78 is designed to be screwthreadedly engageable with plunger 76.
Preferably, syringe body 74 includes a back stop 80 to permit proper gripping by the hand of the user.
At its front end, syringe body 74 includes a female luer connection 82.
Typically, syringe body 74 is filled with a diluent 84 (Figure 7) although any desired fluid may be utilized.

As shown in Figure 7, plunger rod 78 is connected to plunger 76 and the diluent 84 is then forced into vial body 14 as shown in Figure 8. The medicant and diluent may then be mixed and the assembly inverted as shown in Figure 9. The mixture 86 is then aspirated back into syringe body 74. The mixture 86 is then ready for injection when a needle assembly is attached to luer connection 82.

As shown in Figures 14 and 15, the device may include a spike 90 to replace the needle 66. Spike 90 may include a venting channel 92 formed therein to permit pressure equalization upon piercing of the vial. As shown in Figures 16 and 17, various numbers of legs may be employed; in Figures 16 three legs 94 are illustrated.

The embodiment illustrated in Figures 18A to 18J is similar to the previously described embodiment and similar reference numerals will be employed. The primary difference in this embodiment is that a pair of latches 100 extend downwardly from pushing member 44. Each latch 100 has a straight portion 102 and a hooked latch portion 104.

As may be seen in the drawings, latches 100 engage under the neck of vial 14.
As seen in Figures 181 and 18J, when it is desired to withdraw vial 12, the engagement of latches 102 with vial 12 will cause pusher element 44 to be pulled downwardly to a position wherein piercing tip 68 is again protected by pusher member 44. The latches cannot move outwardly to release the vial until pusher element 44 is in the desired position.

A further embodiment of a transfer device 120 is illustrated in Figures 19A to 19H.
-6-The transfer device 120 is similar to that of Figure 18; however, no cover is provided.
Transfer device 120 includes a housing 122 which has a pair of apertures 124 formed therein on opposite sides. As in the previously described embodiment, there is provided a spike 126. Interiorly of housing 122 there are provided a pair of flanges 128 each having a recess 130 formed therein.

Moveable member 132 acts to protect the user from accidental pricks. Moveable member 132 has a base 138 with a first set of legs 134 extending therefrom, each leg 134 having a button 136 formed thereon. Button 136 is designed to engage within aperture 124.

There are also provided a pair of diametrically opposed latches 142 for engaging the neck of the vial.

As shown in Figures 19C to 19H, when housing 122 is engaged with the vial, pressure is exerted on base 138 and moveable member 132 to cause the same to move upwardly whereby buttons 136 engage in apertures 124.

When it is desired to remove the vial, buttons 136 may be depressed and housing 122 moved upwardly with respect to the vial. In so doing, base 138 moves downwardly where it again engages in recesses 130.

It will be understood that the above described embodiment is for purposes of illustration only and that changes and modifications may be made thereto without departing from the spirit and scope of the invention.
-7-

Claims

CA2733446A 2011-03-04 2011-03-04 Easy linking device with retractable protector Abandoned CA2733446A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
CA2733446A CA2733446A1 (en) 2011-03-04 2011-03-04 Easy linking device with retractable protector
US13/261,729 US9381135B2 (en) 2011-03-04 2012-03-05 Easy linking transfer system
AU2012225163A AU2012225163B2 (en) 2011-03-04 2012-03-05 Easy linking transfer system
EP12754579.6A EP2680807B1 (en) 2011-03-04 2012-03-05 Easy linking transfer system
CA2827993A CA2827993C (en) 2011-03-04 2012-03-05 Easy linking transfer system
JP2013556940A JP2014511249A (en) 2011-03-04 2012-03-05 Easy transfer system
PCT/CA2012/000190 WO2012119225A1 (en) 2011-03-04 2012-03-05 Easy linking transfer system
ES12754579.6T ES2593266T3 (en) 2011-03-04 2012-03-05 Easy connection transfer system
CN201280020984.9A CN103501751B (en) 2011-03-04 2012-03-05 The transmission system easily coupled
JP2017062340A JP6502412B2 (en) 2011-03-04 2017-03-28 Easy to connect transport system
JP2018234525A JP6676740B2 (en) 2011-03-04 2018-12-14 Easy connection system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2733446A CA2733446A1 (en) 2011-03-04 2011-03-04 Easy linking device with retractable protector

Publications (1)

Publication Number Publication Date
CA2733446A1 true CA2733446A1 (en) 2012-09-04

Family

ID=46787374

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2733446A Abandoned CA2733446A1 (en) 2011-03-04 2011-03-04 Easy linking device with retractable protector

Country Status (1)

Country Link
CA (1) CA2733446A1 (en)

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Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20130927