CA2727477C - Formulation injectable de paracetamol, stable et prete a l'emploi - Google Patents

Formulation injectable de paracetamol, stable et prete a l'emploi Download PDF

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Publication number
CA2727477C
CA2727477C CA2727477A CA2727477A CA2727477C CA 2727477 C CA2727477 C CA 2727477C CA 2727477 A CA2727477 A CA 2727477A CA 2727477 A CA2727477 A CA 2727477A CA 2727477 C CA2727477 C CA 2727477C
Authority
CA
Canada
Prior art keywords
solution
paracetamol
edta
stable
cyclodextrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2727477A
Other languages
English (en)
Other versions
CA2727477A1 (fr
Inventor
Ioulia Tseti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNI-PHARMA KLEON TSETIS
Original Assignee
UNI-PHARMA KLEON TSETIS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNI-PHARMA KLEON TSETIS filed Critical UNI-PHARMA KLEON TSETIS
Priority to CA2727477A priority Critical patent/CA2727477C/fr
Publication of CA2727477A1 publication Critical patent/CA2727477A1/fr
Application granted granted Critical
Publication of CA2727477C publication Critical patent/CA2727477C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Linvention a trait à une solution aqueuse de paracétamol stable administrable par perfusion intraveineuse qui comprend pour le paracétamol en solution au moins un composé de stabilisation-dissolution pris dans le groupe composé de cyclodextrines hydroxyalkyliques, et au moins un composé de stabilisation, de lEDTA ou du monothioglycérol, seul ou en combinaison, dans une concentration entre 0,001 % et 20 % m/v.
CA2727477A 2011-01-11 2011-01-11 Formulation injectable de paracetamol, stable et prete a l'emploi Expired - Fee Related CA2727477C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2727477A CA2727477C (fr) 2011-01-11 2011-01-11 Formulation injectable de paracetamol, stable et prete a l'emploi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA2727477A CA2727477C (fr) 2011-01-11 2011-01-11 Formulation injectable de paracetamol, stable et prete a l'emploi

Publications (2)

Publication Number Publication Date
CA2727477A1 CA2727477A1 (fr) 2012-07-11
CA2727477C true CA2727477C (fr) 2017-11-21

Family

ID=46491859

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2727477A Expired - Fee Related CA2727477C (fr) 2011-01-11 2011-01-11 Formulation injectable de paracetamol, stable et prete a l'emploi

Country Status (1)

Country Link
CA (1) CA2727477C (fr)

Also Published As

Publication number Publication date
CA2727477A1 (fr) 2012-07-11

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Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20160107

MKLA Lapsed

Effective date: 20210831

MKLA Lapsed

Effective date: 20200113