CA2724132C - Amplification system with spatial separation - Google Patents

Amplification system with spatial separation Download PDF

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Publication number
CA2724132C
CA2724132C CA2724132A CA2724132A CA2724132C CA 2724132 C CA2724132 C CA 2724132C CA 2724132 A CA2724132 A CA 2724132A CA 2724132 A CA2724132 A CA 2724132A CA 2724132 C CA2724132 C CA 2724132C
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CA
Canada
Prior art keywords
analyte
module
rack
cell
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2724132A
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English (en)
French (fr)
Other versions
CA2724132A1 (en
Inventor
Roland Bernet
Andreas Gisler
Marcel Kaeppeli
Raymond Ochsenbein
Thomas Schlaubitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication date
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Publication of CA2724132A1 publication Critical patent/CA2724132A1/en
Application granted granted Critical
Publication of CA2724132C publication Critical patent/CA2724132C/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/54—Supports specially adapted for pipettes and burettes
    • B01L9/543—Supports specially adapted for pipettes and burettes for disposable pipette tips, e.g. racks or cassettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00277—Special precautions to avoid contamination (e.g. enclosures, glove- boxes, sealed sample carriers, disposal of contaminated material)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00326—Analysers with modular structure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Robotics (AREA)
  • Clinical Laboratory Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2724132A 2009-12-10 2010-12-07 Amplification system with spatial separation Active CA2724132C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09178713 2009-12-10
EP09178713.5 2009-12-10
EP10158862 2010-03-31
EP10158862.2 2010-03-31

Publications (2)

Publication Number Publication Date
CA2724132A1 CA2724132A1 (en) 2011-06-10
CA2724132C true CA2724132C (en) 2018-03-06

Family

ID=43718406

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2724132A Active CA2724132C (en) 2009-12-10 2010-12-07 Amplification system with spatial separation

Country Status (7)

Country Link
US (3) US8530229B2 (enExample)
EP (1) EP2333559B1 (enExample)
JP (1) JP5872765B2 (enExample)
CN (1) CN102141572B (enExample)
CA (1) CA2724132C (enExample)
DE (1) DE102010053913A1 (enExample)
FR (2) FR2953932B1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2724106C (en) * 2009-12-10 2018-04-17 F. Hoffmann-La Roche Ag Multiwell plate and lid
CA2724132C (en) * 2009-12-10 2018-03-06 F. Hoffmann-La Roche Ag Amplification system with spatial separation
US9744535B2 (en) * 2010-04-19 2017-08-29 Roche Molecular Systems, Inc. Cassette with multiwell plates
EP2607904B1 (en) * 2011-12-21 2020-01-15 Roche Diagnostics GmbH Method for disposing of a liquid within an automated analytical system, tip rack assembly and analytical system
FR2999012B1 (fr) * 2012-11-30 2017-12-15 Primadiag S A S Module d'attraction magnetique, robot comprenant un tel module, et procede d'utilisation sur billes magnetiques d'un tel module ou d'un tel robot
EP2789389B1 (de) * 2013-04-12 2015-07-29 Eppendorf Ag Vorrichtung zum Bereitstellen von Pipettenspitzen
CH708139A2 (de) * 2013-06-06 2014-12-15 Tecan Trading Ag Pipettiervorrichtung.
CN104786028B (zh) * 2014-01-21 2017-09-22 林顺安 微孔板组装设备和组装方法
EP2929939A1 (en) * 2014-04-07 2015-10-14 Yantai AusBio Laboratories Co., Ltd. Microplate
WO2016130962A1 (en) 2015-02-13 2016-08-18 Abbott Laboratories Automated storage modules for diagnostic analyzer liquids and related systems and methods
US10725059B2 (en) 2015-04-06 2020-07-28 Meso Scale Technologies, Llc. High throughput system for performing assays using electrochemiluminescence including a consumable shaking apparatus
EP3088306A1 (en) * 2015-04-27 2016-11-02 Roche Diagniostics GmbH Recapper, laboratory automation system and method of recapping a sample container
WO2017143182A2 (en) 2016-02-17 2017-08-24 Becton, Dickinson And Company Automated sample preparation system for diagnostic testing of same
CN105628687B (zh) * 2016-02-24 2018-08-07 南京诺尔曼生物技术有限公司 一种全自动化学发光测定仪
EP4234182A3 (en) 2016-04-22 2024-03-20 Becton, Dickinson and Company Automated analyzer piercing stoppers for aspiration
CN109073664B (zh) * 2016-04-22 2022-12-06 贝克顿·迪金森公司 自动诊断分析仪及其操作方法
WO2018087372A1 (en) * 2016-11-11 2018-05-17 Laboratorios Alpha San Ignacio Pharma S.L (Alphasip) System for performing chemical, biological and/or medical processes
WO2018140808A1 (en) * 2017-01-26 2018-08-02 Bio-Rad Laboratories, Inc. Assay performance systems including aqueous sample stabilization
CN106984066A (zh) * 2017-06-06 2017-07-28 利穗科技(苏州)有限公司 一种层析柱维护柱架
US11366133B2 (en) * 2017-10-23 2022-06-21 Shimadzu Corporation Sample plate and auto-sampler
USD886321S1 (en) 2018-01-19 2020-06-02 Biotix, Inc. Pipette tip rack assembly
WO2019169347A1 (en) 2018-03-02 2019-09-06 10X Genomics, Inc. Systems and apparatus for holding plates
JP6694486B2 (ja) 2018-03-29 2020-05-13 バイオティクス， インコーポレイテッド 剛性を高められたピペットチップトレイ
USD888280S1 (en) 2018-03-29 2020-06-23 Biotix, Inc. Pipette tip tray
USD923816S1 (en) 2019-03-20 2021-06-29 Biotix, Inc. Pipette tip tray
CN114008462B (zh) 2019-06-19 2026-01-16 生命技术公司 试剂容器和使用方法
CN114868021A (zh) * 2019-11-21 2022-08-05 10X基因组学有限公司 自动化库发生器
DE102020126552A1 (de) * 2020-10-09 2022-04-14 Syntegon Technology Gmbh Nestausheber und Sterilkammer
US11878304B2 (en) * 2020-12-23 2024-01-23 Tecan Trading Ag Receiving frame for receiving a support plate for pipette tips
US11701663B2 (en) * 2021-06-28 2023-07-18 Xcaliber Sciences, Inc. Pipette tip system
CN117957448A (zh) * 2021-09-07 2024-04-30 贝克顿·迪金森公司 用于自动化诊断分析仪中的库存处理的设备和方法
USD1066739S1 (en) * 2021-09-28 2025-03-11 Xcaliber Sciences, Inc. Pipette tip storage assembly
CN114570450B (zh) * 2022-03-04 2025-11-11 莱杰生物科技(苏州)有限公司 一种叠装有吸头架的空心盒体
TWI840043B (zh) * 2022-12-22 2024-04-21 緯創資通股份有限公司 多功能移液器及自動化檢測機器
WO2024163768A2 (en) * 2023-02-03 2024-08-08 Somalogic Operating Co., Inc. Systems and methods for magnetically separating mixtures
USD1067463S1 (en) * 2023-07-11 2025-03-18 Xcaliber Sciences, Inc. Pipette tip storage assembly
USD1068109S1 (en) * 2023-07-11 2025-03-25 Xcaliber Sciences, Inc. Pipette tip storage assembly
DE102024101354A1 (de) * 2024-01-17 2025-07-17 Hamilton Bonaduz Ag Pipettier-Labormodul mit besonderer Beschickung der Pipettiervorrichtung des Pipettier-Labormoduls

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE446141T1 (de) * 1997-11-14 2009-11-15 Gen Probe Inc Arbeitsgerät zur analyse
DE69940647D1 (de) * 1998-05-01 2009-05-07 Gen Probe Inc Automatische diagnostische Analysevorrichtung
CA2346268A1 (en) * 1998-10-16 2000-04-27 Intelligent Automation Systems Continuous processing automated workstation
US5984844A (en) * 1998-10-21 1999-11-16 Royer; Marc A. Portable exercise device
CN1404415A (zh) * 2000-02-22 2003-03-19 基因谱公司 微阵列制造技术及设备
US6705242B2 (en) * 2002-01-08 2004-03-16 Ch2M Hill Constructors, Inc. Method and apparatus for hermetically sealing openings of an explosion containment chamber
GB0227765D0 (en) * 2002-11-28 2003-01-08 Secr Defence Apparatus for processing a fluid sample
WO2005009202A2 (en) * 2003-05-12 2005-02-03 Isis Pharmaceuticals, Inc. Automatic identification of bioagents
US20050226771A1 (en) 2003-09-19 2005-10-13 Lehto Dennis A High speed microplate transfer
JP4756835B2 (ja) * 2004-07-14 2011-08-24 キヤノン株式会社 生化学反応カートリッジ
DE102004036063A1 (de) * 2004-07-24 2006-02-16 Krones Ag Vorrichtung und Verfahren zur Plasmabeschichtung/Sterilisation
EP1869476A2 (en) * 2005-03-22 2007-12-26 Irm Llc Compound profiling devices, systems, and related methods
EP1929269A2 (en) * 2005-09-30 2008-06-11 Caliper Life Sciences, Inc. Microfluidic device for purifying a biological component using magnetic beads
CN101370622B (zh) * 2006-01-18 2013-07-31 阿戈斯治疗公司 用于处理封闭容器中的样品的系统和方法以及相关装置
JP2008170332A (ja) * 2007-01-12 2008-07-24 Anritsu Sanki System Co Ltd 分注装置
JP2009222634A (ja) * 2008-03-18 2009-10-01 Panasonic Corp マイクロプレートの処理装置
WO2009125971A2 (ko) * 2008-04-09 2009-10-15 (주)바이오니아 자동정제장치, 멀티 웰 플레이트 키트 및 생물학적 시료로부터 핵산을 추출하는 방법
CA2724132C (en) * 2009-12-10 2018-03-06 F. Hoffmann-La Roche Ag Amplification system with spatial separation

Also Published As

Publication number Publication date
US8530229B2 (en) 2013-09-10
CN102141572B (zh) 2015-11-25
US20130323741A1 (en) 2013-12-05
FR2953932B1 (fr) 2015-05-22
EP2333559B1 (en) 2021-01-27
US20110306053A1 (en) 2011-12-15
JP5872765B2 (ja) 2016-03-01
FR3020140A1 (enExample) 2015-10-23
US20130323826A1 (en) 2013-12-05
DE102010053913A1 (de) 2011-12-15
US8809039B2 (en) 2014-08-19
CA2724132A1 (en) 2011-06-10
FR2953932A1 (fr) 2011-06-17
JP2011123067A (ja) 2011-06-23
FR3020140B1 (fr) 2019-12-27
US9365895B2 (en) 2016-06-14
CN102141572A (zh) 2011-08-03
EP2333559A1 (en) 2011-06-15

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