CA2723314C - Templated open flocs of anisotropic particles for enhanced pulmonary delivery - Google Patents
Templated open flocs of anisotropic particles for enhanced pulmonary delivery Download PDFInfo
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- CA2723314C CA2723314C CA2723314A CA2723314A CA2723314C CA 2723314 C CA2723314 C CA 2723314C CA 2723314 A CA2723314 A CA 2723314A CA 2723314 A CA2723314 A CA 2723314A CA 2723314 C CA2723314 C CA 2723314C
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- OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 1
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- ZEWQUBUPAILYHI-UHFFFAOYSA-N trifluoperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 ZEWQUBUPAILYHI-UHFFFAOYSA-N 0.000 description 1
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- 239000002996 urinary tract agent Substances 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US2821808P | 2008-02-13 | 2008-02-13 | |
| US61/028,218 | 2008-02-13 | ||
| PCT/US2009/034162 WO2009103035A2 (en) | 2008-02-13 | 2009-02-13 | Templated open flocs of anisotropic particles for enhanced pulmonary delivery |
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| CA2723314C true CA2723314C (en) | 2017-01-10 |
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| EP2410981B2 (en) | 2009-03-26 | 2020-02-26 | Pulmatrix Operating Company, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| US8506799B2 (en) * | 2009-09-09 | 2013-08-13 | ClearCorp | Suspended particle characterization system for a water processing facility |
| US9248110B2 (en) | 2010-03-18 | 2016-02-02 | Steven Lehrer | Compositions and methods of treating and preventing lung cancer and lymphangioleiomyomatosis |
| WO2011115988A1 (en) * | 2010-03-18 | 2011-09-22 | Steven Lehrer | Compositions and methods of treating and preventing lung cancer |
| US9228785B2 (en) | 2010-05-04 | 2016-01-05 | Alexander Poltorak | Fractal heat transfer device |
| US9061352B2 (en) | 2010-08-30 | 2015-06-23 | Pulmatrix, Inc. | Dry powder formulations and methods for treating pulmonary diseases |
| WO2012030647A1 (en) | 2010-08-30 | 2012-03-08 | Pulmatrix, Inc. | Treatment of cystic fibrosis using calcium lactate, leucine and sodium chloride in a respiraple dry powder |
| CN107096014B (zh) | 2010-09-29 | 2022-07-15 | 普马特里克斯营业公司 | 吸入用单价金属阳离子干粉剂 |
| CA2812417C (en) | 2010-09-29 | 2019-10-22 | Pulmatrix, Inc. | Cationic dry powders |
| WO2014186754A2 (en) | 2013-05-16 | 2014-11-20 | Board Of Regents The University Of Texas System | Dry solid aluminum adjuvant-containing vaccines and related methods thereof |
| CN104274426A (zh) * | 2013-07-03 | 2015-01-14 | 陆克塞纳医药公司 | 昂丹司琼细粉、昂丹司琼气溶胶组合物及其用途 |
| CN104274427A (zh) * | 2013-07-03 | 2015-01-14 | 陆克塞纳医药公司 | 格拉司琼气溶胶组合物及其用途 |
| CA2926719C (en) | 2013-10-08 | 2020-11-24 | Lam Therapeutics, Inc. | Rapamycin for the treatment of lymphangioleiomyomatosis |
| CN112656780A (zh) | 2014-02-20 | 2021-04-16 | 奥迪托皮克股份有限公司 | 用于吸入的干粉制剂 |
| RS64482B1 (sr) | 2014-04-04 | 2023-09-29 | Ai Therapeutics Inc | Inhalaciona formulacija rapamicina za lečenje stanja povezanih sa starenjem |
| CN116687887A (zh) | 2014-07-31 | 2023-09-05 | 维克图拉公司 | 用于吸入的干粉制剂 |
| AU2015330905B2 (en) | 2014-10-07 | 2021-02-25 | AI Therapeutics, Inc. | An inhalable rapamycin formulation for the treatment of pulmonary hypertension |
| CA2983427C (en) * | 2015-05-01 | 2024-04-23 | Board Of Regents, The University Of Texas System | Multidrug brittle matrix compositions |
| MX2018002586A (es) | 2015-09-01 | 2020-11-24 | First Wave Bio Inc | Composiciones para usarse en el tratamiento de afecciones asociadas a una repsuesta inflamatoria anómala. |
| US10550019B2 (en) | 2016-04-08 | 2020-02-04 | OptikTechnik LLC | Automated dosing system and method with light profiling for wastewater filtration system |
| EP3485215B1 (en) | 2016-07-12 | 2023-06-07 | Alexander Poltorak | System and method for maintaining efficiency of a heat sink |
| RU2766086C2 (ru) | 2016-10-14 | 2022-02-07 | Пулматрикс Оперэйтинг Компани, Инк. | Противогрибковые сухие порошки |
| CA3083953A1 (en) | 2017-12-11 | 2019-06-20 | Board Of Regents, The University Of Texas System | Dry adjuvanted immune stimulating compositions and use thereof for mucosal administration |
| WO2019204568A1 (en) * | 2018-04-20 | 2019-10-24 | Board Of Regents, The University Of Texas System | Apparatus and methods for characterizing plume geometry |
| US12091313B2 (en) | 2019-08-26 | 2024-09-17 | The Research Foundation For The State University Of New York | Electrodynamically levitated actuator |
| US10980756B1 (en) | 2020-03-16 | 2021-04-20 | First Wave Bio, Inc. | Methods of treatment |
| WO2021188564A1 (en) | 2020-03-16 | 2021-09-23 | First Wave Bio, Inc. | Methods of treating covid-19 with a niclosamide compound |
| EP4125923A1 (en) | 2020-04-01 | 2023-02-08 | Board of Regents, The University of Texas System | Pharmaceutical compositions of niclosamide |
| US20220023204A1 (en) * | 2020-04-20 | 2022-01-27 | Board Of Regents, The University Of Texas System | Biologically active dry powder compositions and method of their manufacture and use |
| EP4158025A1 (en) | 2020-05-26 | 2023-04-05 | Gradalis, Inc. | Methods for the treatment of viral respiratory infections |
| WO2022055817A1 (en) | 2020-09-09 | 2022-03-17 | Gradalis, Inc. | Composition formulated into inhalable dosage forms for the treatment of lung|tumors |
| US20220362222A1 (en) * | 2021-05-12 | 2022-11-17 | Tff Pharmaceuticals, Inc. | Once daily formulations of tacrolimus |
| US20230112956A1 (en) * | 2021-08-30 | 2023-04-13 | Board Of Regents, The University Of Texas System | Monoclonal antibody dry powders |
| WO2023034844A1 (en) | 2021-08-31 | 2023-03-09 | Board Of Regents, The University Of Texas System | Delayed release niclosamide formulation |
| WO2024059819A2 (en) | 2022-09-15 | 2024-03-21 | Tff Pharmaceuticals, Inc. | Compositions of cannabinoids for delivery by inhalation |
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| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| JPH1112197A (ja) | 1997-06-18 | 1999-01-19 | Cosmo Sogo Kenkyusho:Kk | 悪性腫瘍診断剤及び治療剤 |
| US6565885B1 (en) * | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6284282B1 (en) | 1998-04-29 | 2001-09-04 | Genentech, Inc. | Method of spray freeze drying proteins for pharmaceutical administration |
| US6294192B1 (en) * | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
| US6585957B1 (en) | 2000-01-25 | 2003-07-01 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| AR028746A1 (es) | 2000-06-23 | 2003-05-21 | Norton Health Care Ltd | Cartucho de dosis previamente medidas para inhalador de polvo seco accionado por la respiracion, el inhalador y un metodo de provision de dosis previamente medidas de polvo seco |
| JP2003146523A (ja) | 2001-11-15 | 2003-05-21 | Canon Inc | 画像形成装置 |
| GB0216562D0 (en) * | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
| CA2483218C (en) * | 2002-04-25 | 2012-07-10 | Nektar Therapeutics Uk Ltd | Particulate materials |
| EP1556018A1 (en) | 2002-09-30 | 2005-07-27 | Acusphere, Inc. | Sustained release porous microparticles for inhalation |
| AU2003302274A1 (en) * | 2002-12-31 | 2004-07-29 | Novartis Ag | Aerosolizable pharmaceutical formulation for fungal infection therapy |
| JP4933732B2 (ja) | 2003-01-15 | 2012-05-16 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 低温表面上で凍結させることによって得られる薬物粒子 |
| CA2538237A1 (en) * | 2003-09-10 | 2005-03-24 | Map Pharmaceuticals, Inc. | Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation |
| EP1789018A1 (en) | 2004-08-27 | 2007-05-30 | The Dow Chemical Company | Enhanced delivery of drug compositions to treat life threatening infections |
| WO2008144888A1 (en) * | 2007-05-25 | 2008-12-04 | The University Of British Columbia | Formulations for the oral administration of therapeutic agents and related methods |
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| AU2009214443A1 (en) | 2009-08-20 |
| DK2252275T3 (en) | 2018-03-05 |
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| US10660850B2 (en) | 2020-05-26 |
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| US20100221343A1 (en) | 2010-09-02 |
| US20190117557A1 (en) | 2019-04-25 |
| EP2252275A4 (en) | 2013-11-06 |
| US20210007971A1 (en) | 2021-01-14 |
| US20200069572A1 (en) | 2020-03-05 |
| WO2009103035A3 (en) | 2009-11-12 |
| US20090208582A1 (en) | 2009-08-20 |
| AU2009214443B2 (en) | 2013-10-10 |
| WO2009103035A2 (en) | 2009-08-20 |
| EP2252275A2 (en) | 2010-11-24 |
| US10092512B2 (en) | 2018-10-09 |
| NO2252275T3 (OSRAM) | 2018-04-28 |
| US20250127717A1 (en) | 2025-04-24 |
| US11364197B2 (en) | 2022-06-21 |
| EP2252275B1 (en) | 2017-11-29 |
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