CA2721434A1 - Inhibitors of phosphatidylinositol 3-kinase - Google Patents
Inhibitors of phosphatidylinositol 3-kinase Download PDFInfo
- Publication number
- CA2721434A1 CA2721434A1 CA2721434A CA2721434A CA2721434A1 CA 2721434 A1 CA2721434 A1 CA 2721434A1 CA 2721434 A CA2721434 A CA 2721434A CA 2721434 A CA2721434 A CA 2721434A CA 2721434 A1 CA2721434 A1 CA 2721434A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- disease
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- GBABOYUKABKIAF-IELIFDKJSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-IELIFDKJSA-N 0.000 description 1
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- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4546108P | 2008-04-16 | 2008-04-16 | |
| US61/045,461 | 2008-04-16 | ||
| US10289408P | 2008-10-06 | 2008-10-06 | |
| US61/102,894 | 2008-10-06 | ||
| PCT/US2009/040454 WO2009129211A1 (en) | 2008-04-16 | 2009-04-14 | Inhibitors of phosphatidylinositol 3-kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2721434A1 true CA2721434A1 (en) | 2009-10-22 |
Family
ID=40833464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2721434A Abandoned CA2721434A1 (en) | 2008-04-16 | 2009-04-14 | Inhibitors of phosphatidylinositol 3-kinase |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20110135603A1 (enExample) |
| EP (1) | EP2283013A1 (enExample) |
| JP (1) | JP2011518168A (enExample) |
| CN (1) | CN102083826A (enExample) |
| AU (1) | AU2009236380A1 (enExample) |
| CA (1) | CA2721434A1 (enExample) |
| MX (1) | MX2010011370A (enExample) |
| NZ (1) | NZ588700A (enExample) |
| WO (1) | WO2009129211A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2401557T3 (es) | 2007-08-02 | 2013-04-22 | Amgen, Inc | Moduladores de Pl3 cinasas y métodos de uso |
| BRPI0913300A2 (pt) * | 2008-06-04 | 2018-05-22 | Astrazeneca Ab | composto, processo para o preparo e uso do mesmo, método de tratamento de infecção bacteriana em um animal, e, composição farmacêutica. |
| EP2401273A1 (en) | 2009-02-27 | 2012-01-04 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
| WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
| EP2496567B1 (en) | 2009-11-05 | 2017-07-12 | Rhizen Pharmaceuticals S.A. | Novel benzopyran kinase modulators |
| MX365160B (es) | 2011-05-04 | 2019-05-24 | Rhizen Pharmaceuticals Sa | Compuestos novedosos como moduladores de proteína cinasas. |
| PL2870157T3 (pl) | 2012-07-04 | 2018-01-31 | Rhizen Pharmaceuticals S A | Selektywne inhibitory pi3k delta |
| CN104402875A (zh) * | 2014-12-25 | 2015-03-11 | 西安山川医药科技有限公司 | N-(2-氨基乙基)-n′-(6-取代-2-苯并噻唑基)脲及其盐类化合物的合成方法和用途 |
| WO2025165930A1 (en) * | 2024-01-31 | 2025-08-07 | Biogen Ma Inc. | Methods for treating spinal muscular atrophy |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20070978A1 (es) * | 2006-02-14 | 2007-11-15 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks) |
| EP2057158B8 (en) | 2006-08-30 | 2015-09-30 | Cellzome Limited | Triazole derivatives as kinase inhibitors |
| BRPI0813831A2 (pt) * | 2007-07-18 | 2015-01-06 | Novartis Ag | Compostos de heteroarila bicíclica e seu uso como inibidores de quinase |
| ES2401557T3 (es) * | 2007-08-02 | 2013-04-22 | Amgen, Inc | Moduladores de Pl3 cinasas y métodos de uso |
-
2009
- 2009-04-14 NZ NZ588700A patent/NZ588700A/en not_active IP Right Cessation
- 2009-04-14 EP EP09733572A patent/EP2283013A1/en not_active Withdrawn
- 2009-04-14 CA CA2721434A patent/CA2721434A1/en not_active Abandoned
- 2009-04-14 MX MX2010011370A patent/MX2010011370A/es not_active Application Discontinuation
- 2009-04-14 CN CN2009801180206A patent/CN102083826A/zh active Pending
- 2009-04-14 WO PCT/US2009/040454 patent/WO2009129211A1/en not_active Ceased
- 2009-04-14 JP JP2011505126A patent/JP2011518168A/ja not_active Withdrawn
- 2009-04-14 AU AU2009236380A patent/AU2009236380A1/en not_active Abandoned
-
2010
- 2010-10-15 US US12/905,331 patent/US20110135603A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010011370A (es) | 2010-12-15 |
| JP2011518168A (ja) | 2011-06-23 |
| NZ588700A (en) | 2012-07-27 |
| EP2283013A1 (en) | 2011-02-16 |
| AU2009236380A1 (en) | 2009-10-22 |
| WO2009129211A1 (en) | 2009-10-22 |
| CN102083826A (zh) | 2011-06-01 |
| US20110135603A1 (en) | 2011-06-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20140415 |