CA2720654A1 - Nouveaux composes heteroaromatiques substitues en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase - Google Patents
Nouveaux composes heteroaromatiques substitues en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase Download PDFInfo
- Publication number
- CA2720654A1 CA2720654A1 CA2720654A CA2720654A CA2720654A1 CA 2720654 A1 CA2720654 A1 CA 2720654A1 CA 2720654 A CA2720654 A CA 2720654A CA 2720654 A CA2720654 A CA 2720654A CA 2720654 A1 CA2720654 A1 CA 2720654A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- optionally substituted
- hydrogen
- mmol
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12506508P | 2008-04-22 | 2008-04-22 | |
US61/125,065 | 2008-04-22 | ||
PCT/CA2009/000541 WO2009129625A1 (fr) | 2008-04-22 | 2009-04-21 | Nouveaux composés hétéroaromatiques substitués en tant qu’inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2720654A1 true CA2720654A1 (fr) | 2009-10-29 |
Family
ID=41216376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2720654A Abandoned CA2720654A1 (fr) | 2008-04-22 | 2009-04-21 | Nouveaux composes heteroaromatiques substitues en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase |
Country Status (6)
Country | Link |
---|---|
US (1) | US20110021532A1 (fr) |
EP (1) | EP2279177A1 (fr) |
JP (1) | JP2011518200A (fr) |
AU (1) | AU2009240747A1 (fr) |
CA (1) | CA2720654A1 (fr) |
WO (1) | WO2009129625A1 (fr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012020725A1 (fr) * | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | Dérivé hétérocyclique présentant un antagonisme pour le récepteur npy y5 |
EP2617722B1 (fr) | 2010-09-10 | 2016-03-23 | Shionogi & Co., Ltd. | Dérivé d'imidazole à hétérocycle fusionné ayant un effet d'activation de l'ampk |
WO2012044043A2 (fr) | 2010-09-28 | 2012-04-05 | Daewoong Pharmaceutical Co., Ltd. | Nouveau procédé de préparation de dérivés de benzoimidazole |
WO2013130370A2 (fr) * | 2012-03-01 | 2013-09-06 | Merck Sharp & Dohme Corp. | Composés en tant qu'inhibiteurs de dgat-1 |
US9233102B2 (en) | 2012-03-07 | 2016-01-12 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
US9079866B2 (en) | 2013-02-04 | 2015-07-14 | Janssen Pharmaceutica Nv | Flap modulators |
JP6331052B2 (ja) * | 2014-06-20 | 2018-05-30 | 株式会社Joled | 薄膜トランジスタ、薄膜トランジスタの製造方法及び有機el表示装置 |
WO2018081167A1 (fr) | 2016-10-24 | 2018-05-03 | Yumanity Therapeutics | Composés et utilisations de ces derniers |
BR112019013954A2 (pt) | 2017-01-06 | 2020-02-11 | Yumanity Therapeutics, Inc. | Métodos para o tratamento de distúrbios neurológicos |
EP3570888A1 (fr) | 2017-03-03 | 2019-11-27 | MacRegen, Inc. | Traitement de la dégénérescence maculaire liée à l'âge et d'autres maladies oculaires avec un ou plusieurs agents thérapeutiques |
US11286274B2 (en) | 2017-06-19 | 2022-03-29 | Mitopower Llc | Nicotinamide riboside derivatives and their uses |
EP3654941A1 (fr) | 2017-07-17 | 2020-05-27 | Keith Roizman | Administration topique d'agents thérapeutiques comprenant des peptides de pénétration cellulaire, destinés à être utilisés pour le traitement de la dégénérescence maculaire liée à l'âge et autres maladies oculaires |
CA3083000A1 (fr) | 2017-10-24 | 2019-05-02 | Yumanity Therapeutics, Inc. | Composes et utilisations de ces composes |
EP3735295A1 (fr) | 2018-01-03 | 2020-11-11 | Mederis Diabetes, LLC | Composés pharmaceutiques peptidiques améliorés utilisés pour le traitement d'une stéatohépatite non alcoolique et d'autres troubles |
WO2020131578A2 (fr) | 2018-12-17 | 2020-06-25 | Mitopower Llc | Composés nicotinyl riboside et leurs utilisations |
WO2020179859A1 (fr) | 2019-03-06 | 2020-09-10 | 第一三共株式会社 | Dérivé de pyrrolopyrazole |
WO2020257283A1 (fr) | 2019-06-18 | 2020-12-24 | Mitopower Llc | Composés nicotinyl riboside et leurs utilisations |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7271261B2 (en) * | 2001-10-19 | 2007-09-18 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted benzimidazoles and imidazo-[4,5]-pyridines |
GB0400781D0 (en) * | 2004-01-14 | 2004-02-18 | Novartis Ag | Organic compounds |
CA2572218C (fr) * | 2004-06-30 | 2013-06-11 | Janssen Pharmaceutica, N.V. | Ethers benzimidazole a substitution aryle et imidazopyridine, comme anticancereux |
GB0608724D0 (en) * | 2006-05-03 | 2006-06-14 | Karobio Ab | Novel Pharmaceutical Compositions |
WO2008003753A1 (fr) * | 2006-07-07 | 2008-01-10 | Biovitrum Ab (Publ) | Analogues de pyrazolo [1,5-a] pyrimidine utilisables comme inhibiteurs de l'activité stéaroyl-coa désaturase (scd) |
-
2009
- 2009-04-21 AU AU2009240747A patent/AU2009240747A1/en not_active Abandoned
- 2009-04-21 WO PCT/CA2009/000541 patent/WO2009129625A1/fr active Application Filing
- 2009-04-21 US US12/934,100 patent/US20110021532A1/en not_active Abandoned
- 2009-04-21 CA CA2720654A patent/CA2720654A1/fr not_active Abandoned
- 2009-04-21 EP EP09735195A patent/EP2279177A1/fr not_active Withdrawn
- 2009-04-21 JP JP2011505331A patent/JP2011518200A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2009129625A1 (fr) | 2009-10-29 |
EP2279177A1 (fr) | 2011-02-02 |
AU2009240747A1 (en) | 2009-10-29 |
US20110021532A1 (en) | 2011-01-27 |
JP2011518200A (ja) | 2011-06-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |
Effective date: 20130422 |