CA2703011A1 - Oxazolidinone derivatives and methods of use - Google Patents
Oxazolidinone derivatives and methods of use Download PDFInfo
- Publication number
- CA2703011A1 CA2703011A1 CA2703011A CA2703011A CA2703011A1 CA 2703011 A1 CA2703011 A1 CA 2703011A1 CA 2703011 A CA2703011 A CA 2703011A CA 2703011 A CA2703011 A CA 2703011A CA 2703011 A1 CA2703011 A1 CA 2703011A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- deuterium
- linezolid
- staphylococcus aureus
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims abstract description 63
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 title description 2
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- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 61
- 229910052805 deuterium Inorganic materials 0.000 claims description 61
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
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- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims description 4
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
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- 229940116362 tragacanth Drugs 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85389006P | 2006-10-23 | 2006-10-23 | |
| US60/853,890 | 2006-10-23 | ||
| US97463707P | 2007-09-24 | 2007-09-24 | |
| US60/974,637 | 2007-09-24 | ||
| PCT/US2007/022516 WO2008127300A2 (en) | 2006-10-23 | 2007-10-23 | Oxazolidinone derivatives and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2703011A1 true CA2703011A1 (en) | 2008-10-23 |
Family
ID=39864509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2703011A Abandoned CA2703011A1 (en) | 2006-10-23 | 2007-10-23 | Oxazolidinone derivatives and methods of use |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20080139563A1 (enExample) |
| EP (1) | EP2099299A4 (enExample) |
| JP (1) | JP5302200B2 (enExample) |
| CA (1) | CA2703011A1 (enExample) |
| WO (1) | WO2008127300A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017089892A1 (en) * | 2015-11-25 | 2017-06-01 | Astrazeneca Ab | Deuterated isoxazole derivatives and their use as metabotropic glutamate receptor potentiators |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8796267B2 (en) * | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
| US20080146573A1 (en) * | 2006-12-04 | 2008-06-19 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted oxzolidinones |
| US20090062283A1 (en) * | 2007-08-29 | 2009-03-05 | Protia, Llc | Deuterium-enriched linezolid |
| US8354557B2 (en) * | 2008-06-17 | 2013-01-15 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated morpholine derivatives |
| NZ599151A (en) * | 2009-10-13 | 2014-07-25 | Melinta Therapeutics Inc | Pharmaceutical composition comprising radezolid or salt thereof and uses thereof |
| CN104327004A (zh) * | 2014-11-17 | 2015-02-04 | 重庆华邦制药有限公司 | 高纯度利奈唑胺氮氧化物的制备方法 |
| KR101811437B1 (ko) * | 2015-09-17 | 2018-01-25 | 서울대학교산학협력단 | 그람 음성균에 대한 항균 활성을 나타내는 끊어진 또는 꺾어진 나선 펩타이드 또는 펩타이드 유사체 및 이의 용도 |
| US11608320B2 (en) | 2020-02-02 | 2023-03-21 | Kuwait University | Oxazolidinone hydroxamic acid derivatives |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| EP1019385B1 (en) * | 1995-09-15 | 2004-01-14 | PHARMACIA & UPJOHN COMPANY | Aminoaryl oxazolidinone n-oxides |
| US6255304B1 (en) * | 1997-05-30 | 2001-07-03 | Pharmacia & Upjohn Company | Oxazolidinone antibacterial agents having a thiocarbonyl functionality |
| US6884429B2 (en) * | 1997-09-05 | 2005-04-26 | Isotechnika International Inc. | Medical devices incorporating deuterated rapamycin for controlled delivery thereof |
| EP1049682A1 (en) * | 1998-01-23 | 2000-11-08 | Versicor, Inc. | Oxazolidinone combinatorial libraries, compositions and methods of preparation |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| EP1104760B1 (en) * | 1999-12-03 | 2003-03-12 | Pfizer Products Inc. | Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents |
| AR027261A1 (es) * | 2000-02-02 | 2003-03-19 | Upjohn Co | Linezolid forma cristalina ii |
| EP1231209A1 (en) * | 2000-12-19 | 2002-08-14 | Specialized Pharmaceutical Research Ltd. Co. | Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compound |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| TWI410409B (zh) * | 2005-07-26 | 2013-10-01 | Takeda Gmbh | 同位素取代之潘托拉唑（ｐａｎｔｏｐｒａｚｏｌｅ） |
| JP5301991B2 (ja) * | 2005-07-29 | 2013-09-25 | コンサート ファーマシューティカルズ インコーポレイテッド | 新規なベンゾ［ｄ］［１，３］−ジオキソール誘導体 |
| CA2624179A1 (en) * | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| CA2661404A1 (en) * | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| US8796267B2 (en) * | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
| US20080146573A1 (en) * | 2006-12-04 | 2008-06-19 | Auspex Pharmaceuticals, Inc. | Preparation and utility of substituted oxzolidinones |
-
2007
- 2007-10-23 EP EP07873459A patent/EP2099299A4/en not_active Withdrawn
- 2007-10-23 CA CA2703011A patent/CA2703011A1/en not_active Abandoned
- 2007-10-23 US US11/877,666 patent/US20080139563A1/en not_active Abandoned
- 2007-10-23 JP JP2009533406A patent/JP5302200B2/ja not_active Expired - Fee Related
- 2007-10-23 WO PCT/US2007/022516 patent/WO2008127300A2/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017089892A1 (en) * | 2015-11-25 | 2017-06-01 | Astrazeneca Ab | Deuterated isoxazole derivatives and their use as metabotropic glutamate receptor potentiators |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008127300A2 (en) | 2008-10-23 |
| EP2099299A4 (en) | 2011-11-30 |
| JP2010507576A (ja) | 2010-03-11 |
| US20080139563A1 (en) | 2008-06-12 |
| WO2008127300A3 (en) | 2008-12-11 |
| JP5302200B2 (ja) | 2013-10-02 |
| EP2099299A2 (en) | 2009-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20131023 |