CA2696653A1 - Mammalian genes involved in viral infection and tumor suppression - Google Patents
Mammalian genes involved in viral infection and tumor suppression Download PDFInfo
- Publication number
- CA2696653A1 CA2696653A1 CA2696653A CA2696653A CA2696653A1 CA 2696653 A1 CA2696653 A1 CA 2696653A1 CA 2696653 A CA2696653 A CA 2696653A CA 2696653 A CA2696653 A CA 2696653A CA 2696653 A1 CA2696653 A1 CA 2696653A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- nucleic acid
- gene product
- gene
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 40
- 208000036142 Viral infection Diseases 0.000 title claims abstract description 14
- 230000009385 viral infection Effects 0.000 title claims abstract description 14
- 230000005760 tumorsuppression Effects 0.000 title description 2
- 108020004707 nucleic acids Proteins 0.000 claims abstract 32
- 102000039446 nucleic acids Human genes 0.000 claims abstract 32
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 32
- 238000000034 method Methods 0.000 claims abstract 17
- 238000012216 screening Methods 0.000 claims abstract 6
- 230000001413 cellular effect Effects 0.000 claims abstract 5
- 230000003612 virological effect Effects 0.000 claims abstract 2
- 210000004027 cell Anatomy 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000002773 nucleotide Substances 0.000 claims 9
- 125000003729 nucleotide group Chemical group 0.000 claims 9
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 230000003211 malignant effect Effects 0.000 claims 4
- 108700008625 Reporter Genes Proteins 0.000 claims 3
- 230000008030 elimination Effects 0.000 claims 3
- 238000003379 elimination reaction Methods 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 3
- 102000005221 Cleavage Stimulation Factor Human genes 0.000 claims 2
- 108010081236 Cleavage Stimulation Factor Proteins 0.000 claims 2
- 102100039436 DNA-binding protein inhibitor ID-3 Human genes 0.000 claims 2
- 101710152064 DNA-binding protein inhibitor ID-3 Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 230000004083 survival effect Effects 0.000 claims 2
- 102100028505 6-pyruvoyl tetrahydrobiopterin synthase Human genes 0.000 claims 1
- 108010045523 6-pyruvoyltetrahydropterin synthase Proteins 0.000 claims 1
- 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 1
- 101000795753 Homo sapiens mRNA decay activator protein ZFP36 Proteins 0.000 claims 1
- 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
- 102100026888 Mitogen-activated protein kinase kinase kinase 7 Human genes 0.000 claims 1
- 102100030608 Mothers against decapentaplegic homolog 7 Human genes 0.000 claims 1
- 101700026522 SMAD7 Proteins 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 108010065850 Tristetraprolin Proteins 0.000 claims 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 108010070113 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase I Proteins 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 102100031622 mRNA decay activator protein ZFP36 Human genes 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108091008743 testicular receptors 4 Proteins 0.000 claims 1
- 239000011701 zinc Substances 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 238000004113 cell culture Methods 0.000 abstract 1
- 241000700157 Rattus norvegicus Species 0.000 description 127
- 101150110946 gatC gene Proteins 0.000 description 5
- VWEWCZSUWOEEFM-WDSKDSINSA-N Ala-Gly-Ala-Gly Chemical compound C[C@H](N)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(O)=O VWEWCZSUWOEEFM-WDSKDSINSA-N 0.000 description 2
- 101100476480 Mus musculus S100a8 gene Proteins 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/60—Vectors containing traps for, e.g. exons, promoters
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6202197P | 1997-10-10 | 1997-10-10 | |
| US60/062,021 | 1997-10-10 | ||
| CA2305312A CA2305312C (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2305312A Division CA2305312C (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2696653A1 true CA2696653A1 (en) | 1999-04-22 |
Family
ID=22039706
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2305312A Expired - Fee Related CA2305312C (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
| CA2696653A Abandoned CA2696653A1 (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2305312A Expired - Fee Related CA2305312C (en) | 1997-10-10 | 1998-10-08 | Mammalian genes involved in viral infection and tumor suppression |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1021536A2 (enExample) |
| JP (2) | JP2001520012A (enExample) |
| AU (1) | AU9604198A (enExample) |
| CA (2) | CA2305312C (enExample) |
| WO (1) | WO1999019481A2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001016323A2 (en) * | 1999-09-01 | 2001-03-08 | Subsidiary N0.3, Inc. | Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes |
| JP2002300900A (ja) * | 2001-04-05 | 2002-10-15 | National Institute Of Advanced Industrial & Technology | 腫瘍悪性化因子および腫瘍悪性化を抑制する化合物のスクリーニング方法 |
| EP1409736A4 (en) * | 2001-06-29 | 2004-07-21 | Subsidiary N0 3 Inc | COMPOSITIONS AND METHODS FOR INHIBITING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BY NEGATIVE REGULATION OF HUMAN CELL GENES |
| CA2485092A1 (en) * | 2002-05-02 | 2004-02-05 | Vanderbilt University | Mammalian genes involved in viral infection and tumor suppression |
| EP2339009A1 (en) * | 2009-12-22 | 2011-06-29 | Sandoz Ag | Cold inducible promoter sequences |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0458901B1 (en) * | 1989-02-14 | 1997-12-17 | Massachusetts Institute Of Technology | Inhibiting transformation of cells having elevated purine metabolic enzyme activity |
| US5364783A (en) * | 1990-05-14 | 1994-11-15 | Massachusetts Institute Of Technology | Retrovirus promoter-trap vectors |
| US5350835A (en) * | 1991-11-05 | 1994-09-27 | Board Of Regents, University Of Texas | Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids |
| CA2251818A1 (en) * | 1996-04-15 | 1997-10-23 | Vanderbilt University | Mammalian genes involved in viral infection and tumor suppression |
-
1998
- 1998-10-08 JP JP2000516033A patent/JP2001520012A/ja not_active Withdrawn
- 1998-10-08 CA CA2305312A patent/CA2305312C/en not_active Expired - Fee Related
- 1998-10-08 CA CA2696653A patent/CA2696653A1/en not_active Abandoned
- 1998-10-08 AU AU96041/98A patent/AU9604198A/en not_active Abandoned
- 1998-10-08 WO PCT/US1998/021276 patent/WO1999019481A2/en not_active Ceased
- 1998-10-08 EP EP98949800A patent/EP1021536A2/en not_active Withdrawn
-
2009
- 2009-02-16 JP JP2009033300A patent/JP2009100780A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999019481A2 (en) | 1999-04-22 |
| EP1021536A2 (en) | 2000-07-26 |
| JP2009100780A (ja) | 2009-05-14 |
| AU9604198A (en) | 1999-05-03 |
| CA2305312A1 (en) | 1999-04-22 |
| WO1999019481A3 (en) | 1999-11-04 |
| CA2305312C (en) | 2010-03-23 |
| JP2001520012A (ja) | 2001-10-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Dead |