CA2305312C - Mammalian genes involved in viral infection and tumor suppression - Google Patents

Mammalian genes involved in viral infection and tumor suppression Download PDF

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Publication number
CA2305312C
CA2305312C CA2305312A CA2305312A CA2305312C CA 2305312 C CA2305312 C CA 2305312C CA 2305312 A CA2305312 A CA 2305312A CA 2305312 A CA2305312 A CA 2305312A CA 2305312 C CA2305312 C CA 2305312C
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CA
Canada
Prior art keywords
seq
gene
nucleic acid
cell
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2305312A
Other languages
English (en)
French (fr)
Other versions
CA2305312A1 (en
Inventor
Donald H. Rubin
Edward L. Organ
Raymond N. Dubois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Priority to CA2696653A priority Critical patent/CA2696653A1/en
Publication of CA2305312A1 publication Critical patent/CA2305312A1/en
Application granted granted Critical
Publication of CA2305312C publication Critical patent/CA2305312C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1051Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1082Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011Details
    • C12N2720/12011Reoviridae
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/60Vectors containing traps for, e.g. exons, promoters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CA2305312A 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression Expired - Fee Related CA2305312C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2696653A CA2696653A1 (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6202197P 1997-10-10 1997-10-10
US60/062,021 1997-10-10
PCT/US1998/021276 WO1999019481A2 (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2696653A Division CA2696653A1 (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression

Publications (2)

Publication Number Publication Date
CA2305312A1 CA2305312A1 (en) 1999-04-22
CA2305312C true CA2305312C (en) 2010-03-23

Family

ID=22039706

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2696653A Abandoned CA2696653A1 (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression
CA2305312A Expired - Fee Related CA2305312C (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2696653A Abandoned CA2696653A1 (en) 1997-10-10 1998-10-08 Mammalian genes involved in viral infection and tumor suppression

Country Status (5)

Country Link
EP (1) EP1021536A2 (enExample)
JP (2) JP2001520012A (enExample)
AU (1) AU9604198A (enExample)
CA (2) CA2696653A1 (enExample)
WO (1) WO1999019481A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016323A2 (en) * 1999-09-01 2001-03-08 Subsidiary N0.3, Inc. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
JP2002300900A (ja) * 2001-04-05 2002-10-15 National Institute Of Advanced Industrial & Technology 腫瘍悪性化因子および腫瘍悪性化を抑制する化合物のスクリーニング方法
US20030087273A1 (en) * 2001-06-29 2003-05-08 Holzmayer Tanya A. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
EP1572084A4 (en) * 2002-05-02 2008-04-30 Univ Vanderbilt MAMMALS WITH PARTICIPATION IN VIRUS INFECTION AND TUMORSUPPRESSION
EP2339009A1 (en) * 2009-12-22 2011-06-29 Sandoz Ag Cold inducible promoter sequences

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2114531T3 (es) * 1989-02-14 1998-06-01 Massachusetts Inst Technology Inhibicion de la transformacion de celulas que tienen una actividad enzimatica elevada del metabolismo de purinas.
US5364783A (en) * 1990-05-14 1994-11-15 Massachusetts Institute Of Technology Retrovirus promoter-trap vectors
US5350835A (en) * 1991-11-05 1994-09-27 Board Of Regents, University Of Texas Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
AU742243B2 (en) * 1996-04-15 2001-12-20 Vanderbilt University Mammalian genes involved in viral infection and tumor suppression

Also Published As

Publication number Publication date
JP2009100780A (ja) 2009-05-14
WO1999019481A3 (en) 1999-11-04
WO1999019481A2 (en) 1999-04-22
CA2696653A1 (en) 1999-04-22
AU9604198A (en) 1999-05-03
CA2305312A1 (en) 1999-04-22
EP1021536A2 (en) 2000-07-26
JP2001520012A (ja) 2001-10-30

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Effective date: 20131009