CA2689101C - Modifying drug release in suspensions of ionic resin systems - Google Patents

Modifying drug release in suspensions of ionic resin systems Download PDF

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Publication number
CA2689101C
CA2689101C CA2689101A CA2689101A CA2689101C CA 2689101 C CA2689101 C CA 2689101C CA 2689101 A CA2689101 A CA 2689101A CA 2689101 A CA2689101 A CA 2689101A CA 2689101 C CA2689101 C CA 2689101C
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CA
Canada
Prior art keywords
poly
pharmacologically active
acid
drug
release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2689101A
Other languages
English (en)
French (fr)
Other versions
CA2689101A1 (en
Inventor
Yashwant Vishnupant Pathak
Russell Lee Mcmahen
Mark Tengler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neos Therapeutics LP
Original Assignee
Neos Therapeutics LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neos Therapeutics LP filed Critical Neos Therapeutics LP
Publication of CA2689101A1 publication Critical patent/CA2689101A1/en
Application granted granted Critical
Publication of CA2689101C publication Critical patent/CA2689101C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2689101A 2007-05-30 2008-05-30 Modifying drug release in suspensions of ionic resin systems Active CA2689101C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94095607P 2007-05-30 2007-05-30
US60/940,956 2007-05-30
PCT/US2008/065408 WO2008151071A1 (en) 2007-05-30 2008-05-30 Modifying drug release in suspensions of ionic resin systems

Publications (2)

Publication Number Publication Date
CA2689101A1 CA2689101A1 (en) 2008-12-11
CA2689101C true CA2689101C (en) 2013-01-22

Family

ID=40094143

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2689101A Active CA2689101C (en) 2007-05-30 2008-05-30 Modifying drug release in suspensions of ionic resin systems

Country Status (6)

Country Link
US (1) US8313770B2 (https=)
EP (1) EP2164631A4 (https=)
JP (1) JP2010529040A (https=)
CA (1) CA2689101C (https=)
MX (1) MX2009013019A (https=)
WO (1) WO2008151071A1 (https=)

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JP5425080B2 (ja) 2007-09-06 2014-02-26 ザ コカ・コーラ カンパニー 複数の製品形成原料の分注を監視および制御するためのシステムおよび方法
EP2227434A2 (en) 2007-09-06 2010-09-15 The Coca-Cola Company Systems and methods for providing portion control programming in a product forming dispenser
US20100273822A1 (en) * 2009-04-22 2010-10-28 William Wayne Howard Immediate release compositions and methods for delivering drug formulations using strong acid ion exchange resins
MX365650B (es) 2009-12-02 2019-06-10 Adamas Pharmaceuticals Inc Composiciones de amantadina y metodos para su uso.
US8470375B1 (en) 2010-01-05 2013-06-25 Neos Therapeutics, Lp Method of formulating and designing liquid drug suspensions containing ion exchange resin particles
US20130230587A1 (en) * 2010-11-10 2013-09-05 Rubicon Research Private Limited Sustained release compositions
US9339478B2 (en) * 2011-02-04 2016-05-17 Reckitt Benckiser Llc Pharmaceutical formulation
US8287903B2 (en) * 2011-02-15 2012-10-16 Tris Pharma Inc Orally effective methylphenidate extended release powder and aqueous suspension product
EP2508174A1 (en) * 2011-04-06 2012-10-10 Ljiljana Sovic Brkicic Pharmaceutical composition
US20130004586A1 (en) * 2011-06-24 2013-01-03 Vachon David J Biologically Efficacious Compositions, Articles of Manufacture and Processes for Producing and/or Using Same
WO2013003622A1 (en) 2011-06-28 2013-01-03 Neos Therapeutics, Lp Dosage forms for oral administration and methods of treatment using the same
CA2880456A1 (en) 2012-08-15 2014-02-20 Tris Pharma, Inc. Methylphenidate extended release chewable tablet
US20140122120A1 (en) * 2012-10-30 2014-05-01 Pacesetter, Inc. Systems and methods for providing photo-based patient verification for use with implantable medical device programmers
ES2792082T3 (es) 2013-02-28 2020-11-10 Pf Consumer Healthcare 1 Llc Estabilidad mejorada de composiciones líquidas novedosas
US10154971B2 (en) 2013-06-17 2018-12-18 Adamas Pharma, Llc Methods of administering amantadine
WO2016001937A2 (en) * 2014-06-30 2016-01-07 Rubicon Research Private Limited Modified release pharmaceutical preparations
CA2962950A1 (en) * 2014-10-01 2016-04-07 Crop Enhancement, Inc. Agrochemical resinates for agricultural applications
US11590228B1 (en) 2015-09-08 2023-02-28 Tris Pharma, Inc Extended release amphetamine compositions
MX2018013410A (es) * 2016-05-03 2019-06-06 Spectrix Therapeutics Llc Composiciones y metodos para proporcionar la hormona tiroidea o analogos de la misma.
CA3072764A1 (en) 2017-08-24 2019-02-28 Adamas Pharma, Llc Amantadine compositions, preparations thereof, and methods of use
US12458592B1 (en) 2017-09-24 2025-11-04 Tris Pharma, Inc. Extended release amphetamine tablets
US11590081B1 (en) 2017-09-24 2023-02-28 Tris Pharma, Inc Extended release amphetamine tablets
IL311303B1 (en) 2017-10-09 2026-01-01 Rhodes Pharmaceuticals Lp Medicinal resin components and methods for their production and use
WO2019094292A1 (en) * 2017-11-09 2019-05-16 Spectrix Therapeutics, LLC Compositions and methods of providing thyroid hormone of analogs thereof
WO2019126216A1 (en) 2017-12-18 2019-06-27 Tris Phama, Inc. Pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
EP3737353A1 (en) 2017-12-18 2020-11-18 Tris Pharma, Inc. Ghb pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
US11337919B2 (en) 2017-12-18 2022-05-24 Tris Pharma, Inc. Modified release drug powder composition comprising gastro-retentive RAFT forming systems having trigger pulse drug release
WO2019126214A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Pharmaceutical composition comprising ghb gastro-retentive raft forming systems having trigger pulse drug release
WO2024163966A1 (en) 2023-02-03 2024-08-08 Tris Pharma, Inc. Low sodium oxybate once nightly composition

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Also Published As

Publication number Publication date
JP2010529040A (ja) 2010-08-26
EP2164631A4 (en) 2013-08-21
EP2164631A1 (en) 2010-03-24
CA2689101A1 (en) 2008-12-11
US20090011027A1 (en) 2009-01-08
WO2008151071A1 (en) 2008-12-11
MX2009013019A (es) 2010-04-01
US8313770B2 (en) 2012-11-20

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