CA2680134A1 - Restrictive agonist of toll-like receptor 3 (tlr3) - Google Patents
Restrictive agonist of toll-like receptor 3 (tlr3) Download PDFInfo
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- CA2680134A1 CA2680134A1 CA002680134A CA2680134A CA2680134A1 CA 2680134 A1 CA2680134 A1 CA 2680134A1 CA 002680134 A CA002680134 A CA 002680134A CA 2680134 A CA2680134 A CA 2680134A CA 2680134 A1 CA2680134 A1 CA 2680134A1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/533—Physical structure partially self-complementary or closed having a mismatch or nick in at least one of the strands
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- C—CHEMISTRY; METALLURGY
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/12011—Bunyaviridae
- C12N2760/12211—Phlebovirus, e.g. Rift Valley fever virus
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| US90479207P | 2007-03-05 | 2007-03-05 | |
| US60/904,792 | 2007-03-05 | ||
| PCT/US2008/002874 WO2008109083A2 (en) | 2007-03-05 | 2008-03-05 | Restrictive agonist of toll-like receptor 3 (tlr3) |
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| CA2680134A1 true CA2680134A1 (en) | 2008-09-12 |
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| CA002680134A Abandoned CA2680134A1 (en) | 2007-03-05 | 2008-03-05 | Restrictive agonist of toll-like receptor 3 (tlr3) |
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| EP (1) | EP2134172A4 (enExample) |
| JP (1) | JP2010520284A (enExample) |
| KR (1) | KR20090130019A (enExample) |
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| AU2006322073A1 (en) | 2005-12-07 | 2007-06-14 | Hemispherx Biopharma, Inc. | dsRNAs as influenza virus vaccine adjuvants or immuno-stimulants |
| AU2009215128A1 (en) * | 2008-02-15 | 2009-08-20 | Hemispherx Biopharma, Inc. | Selective agonist of toll-like receptor 3 |
| SI2340307T1 (sl) | 2008-10-23 | 2016-02-29 | Hemispherx Biopharma, Inc. | Dvoverižne ribonukleinske kisline z robustno fizikalno-kemijsko strukturo in zelo specifično biološko aktivnostjo |
| US8722874B2 (en) | 2008-10-23 | 2014-05-13 | Hemispherx Biopharma, Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| US20100160413A1 (en) | 2008-10-23 | 2010-06-24 | Hemispherx Biopharma, Inc. | Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity |
| HUE031756T2 (en) * | 2008-10-31 | 2017-07-28 | Janssen Biotech Inc | TLR3 antagonists |
| WO2011072871A1 (en) * | 2009-12-18 | 2011-06-23 | Bavarian Nordic A/S | Production of ifn-lambda by conventional dendritic cells and uses thereof |
| CN101780279B (zh) * | 2009-12-22 | 2012-07-11 | 中山大学中山眼科中心 | Toll-like receptor-3激动剂在制备促进伤口愈合的药物中的应用 |
| WO2011130379A1 (en) * | 2010-04-13 | 2011-10-20 | Novartis Ag | Benzonapthyridine compositions and uses thereof |
| ES2620748T3 (es) * | 2010-06-25 | 2017-06-29 | Idera Pharmaceuticals, Inc. | Nuevos agonistas del receptor de tipo toll 3 y procedimientos de su utilización |
| WO2015127002A1 (en) * | 2014-02-19 | 2015-08-27 | The Johns Hopkins University | Compositions and methods for promoting skin regeneration and hair growth |
| EP3321362A1 (en) | 2016-11-10 | 2018-05-16 | Centre Leon Berard | Tlr3 agonist for use for inducing apoptosis in senescent cancer cells |
| MX2019007583A (es) * | 2016-12-22 | 2019-09-04 | Intervet Int Bv | Vacuna de eimeria con una eficacia mejorada. |
| EP3833383A1 (en) | 2018-08-06 | 2021-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cancers |
| WO2020232226A1 (en) | 2019-05-16 | 2020-11-19 | The Johns Hopkins University | Compositions and methods for skin rejuvenation |
| US20240216364A1 (en) | 2021-04-28 | 2024-07-04 | Enyo Pharma | Strong potentiation of tlr3 agonists effects using fxr agonists as a combined treatment |
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| US6080726A (en) * | 1985-08-12 | 2000-06-27 | University Of Maryland | Anti-viral and immuno stimulator polynucleotide duplex and use thereof |
| US5063209A (en) * | 1985-08-26 | 1991-11-05 | Hem Research, Inc. | Modulation of aids virus-related events by double-stranded RNAs |
| US5683986A (en) * | 1987-08-12 | 1997-11-04 | Hemispherx Biopharma Inc. | Elaboration of host defense mediators into biological fluids by systemic dsRNA treatment |
| IE72103B1 (en) * | 1987-08-12 | 1997-03-12 | Hem Res Inc | Promotion of host defense by systemic dsRNA treatment |
| AU3583797A (en) * | 1996-06-28 | 1998-01-21 | Regents Of The University Of California, The | Enhancement of cancer cell death |
| GB0119346D0 (en) * | 2001-08-08 | 2001-10-03 | Bioclones Proprietary Ltd | Process for the maturation of dendritic cells |
| US20060211752A1 (en) * | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| WO2006054129A1 (en) * | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
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| JP2010520284A (ja) | 2010-06-10 |
| WO2008109083A2 (en) | 2008-09-12 |
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| AU2008223446B2 (en) | 2012-02-02 |
| CN101652062A (zh) | 2010-02-17 |
| KR20090130019A (ko) | 2009-12-17 |
| AU2008223446A1 (en) | 2008-09-12 |
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| EEER | Examination request |
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| FZDE | Discontinued |
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