CA2667243A1 - Compensation de temperature pour des electrodes a enzyme - Google Patents
Compensation de temperature pour des electrodes a enzyme Download PDFInfo
- Publication number
- CA2667243A1 CA2667243A1 CA002667243A CA2667243A CA2667243A1 CA 2667243 A1 CA2667243 A1 CA 2667243A1 CA 002667243 A CA002667243 A CA 002667243A CA 2667243 A CA2667243 A CA 2667243A CA 2667243 A1 CA2667243 A1 CA 2667243A1
- Authority
- CA
- Canada
- Prior art keywords
- temperature
- electrode
- sensor
- current
- catheter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108090000790 Enzymes Proteins 0.000 title claims abstract description 31
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 31
- 238000005259 measurement Methods 0.000 claims abstract description 28
- 238000000034 method Methods 0.000 claims abstract description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 67
- 239000008103 glucose Substances 0.000 claims description 67
- 239000012530 fluid Substances 0.000 claims description 15
- 239000012528 membrane Substances 0.000 claims description 15
- 239000012491 analyte Substances 0.000 claims description 9
- 238000012544 monitoring process Methods 0.000 claims description 7
- 238000012937 correction Methods 0.000 claims description 6
- 230000037361 pathway Effects 0.000 claims description 5
- 230000001419 dependent effect Effects 0.000 claims description 4
- 229920002635 polyurethane Polymers 0.000 claims description 4
- 239000004814 polyurethane Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 2
- 230000037431 insertion Effects 0.000 claims description 2
- 229920005597 polymer membrane Polymers 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000008859 change Effects 0.000 description 20
- 238000011088 calibration curve Methods 0.000 description 17
- 239000008280 blood Substances 0.000 description 15
- 210000004369 blood Anatomy 0.000 description 15
- 229940088598 enzyme Drugs 0.000 description 9
- 238000001802 infusion Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000003978 infusion fluid Substances 0.000 description 4
- 230000036760 body temperature Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 102000005548 Hexokinase Human genes 0.000 description 1
- 108700040460 Hexokinases Proteins 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
- A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
- A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
- A61B2560/0252—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value using ambient temperature
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Surgery (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'invention concerne un procédé de compensation de température pour une électrode à enzyme par mesure d'une température fonctionnelle de l'électrode à enzyme, mesure du courant généré par l'électrode à enzyme, détermination d'un écart de mesure entre le courant généré et un courant de référence à la température fonctionnelle, détermination d'une concentration en enzyme correspondant au courant mesuré et étalonnage de la concentration en enzyme pour compenser l'écart de mesure.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85958606P | 2006-11-16 | 2006-11-16 | |
| US60/859,586 | 2006-11-16 | ||
| PCT/US2007/084993 WO2008076574A2 (fr) | 2006-11-16 | 2007-11-16 | Compensation de température pour des électrodes à enzyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2667243A1 true CA2667243A1 (fr) | 2008-06-26 |
Family
ID=39536945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002667243A Abandoned CA2667243A1 (fr) | 2006-11-16 | 2007-11-16 | Compensation de temperature pour des electrodes a enzyme |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2088927A2 (fr) |
| CN (1) | CN101541239A (fr) |
| CA (1) | CA2667243A1 (fr) |
| WO (1) | WO2008076574A2 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5341996B2 (ja) * | 2009-06-30 | 2013-11-13 | アークレイ株式会社 | 分析装置および分析方法 |
| TWI458979B (zh) * | 2011-03-18 | 2014-11-01 | Eps Bio Technology Corp | 補償環境溫度效應的生化感測器及其方法 |
| CN109790562B (zh) * | 2016-09-07 | 2023-08-15 | 豪夫迈·罗氏有限公司 | 用于测试基于酶的电化学传感器的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4431004A (en) * | 1981-10-27 | 1984-02-14 | Bessman Samuel P | Implantable glucose sensor |
| US4703756A (en) * | 1986-05-06 | 1987-11-03 | The Regents Of The University Of California | Complete glucose monitoring system with an implantable, telemetered sensor module |
| ES2610579T3 (es) * | 2003-12-18 | 2017-04-28 | Metronom Health, Inc. | Matriz de transporte de oxígeno estabilizada |
-
2007
- 2007-11-16 CA CA002667243A patent/CA2667243A1/fr not_active Abandoned
- 2007-11-16 CN CNA2007800425419A patent/CN101541239A/zh active Pending
- 2007-11-16 EP EP07871509A patent/EP2088927A2/fr not_active Withdrawn
- 2007-11-16 WO PCT/US2007/084993 patent/WO2008076574A2/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| CN101541239A (zh) | 2009-09-23 |
| WO2008076574A3 (fr) | 2009-02-05 |
| WO2008076574A2 (fr) | 2008-06-26 |
| EP2088927A2 (fr) | 2009-08-19 |
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| CA2667243A1 (fr) | Compensation de temperature pour des electrodes a enzyme | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20111116 |