CA2659429A1 - 4-oxo-4,5-dihydropyrrolo[1,2-a]quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp) - Google Patents

4-oxo-4,5-dihydropyrrolo[1,2-a]quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp) Download PDF

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Publication number
CA2659429A1
CA2659429A1 CA002659429A CA2659429A CA2659429A1 CA 2659429 A1 CA2659429 A1 CA 2659429A1 CA 002659429 A CA002659429 A CA 002659429A CA 2659429 A CA2659429 A CA 2659429A CA 2659429 A1 CA2659429 A1 CA 2659429A1
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CA
Canada
Prior art keywords
compound
6alkyl
pharmaceutically acceptable
ring containing
compounds
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Abandoned
Application number
CA002659429A
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English (en)
French (fr)
Inventor
Philip Jones
Uwe Koch
Jesus Maria Ontoria Ontoria
Rita Scarpelli
Carsten Schultz-Fademrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
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Individual
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Publication of CA2659429A1 publication Critical patent/CA2659429A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
CA002659429A 2006-08-09 2007-08-06 4-oxo-4,5-dihydropyrrolo[1,2-a]quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp) Abandoned CA2659429A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0615809.1 2006-08-09
GBGB0615809.1A GB0615809D0 (en) 2006-08-09 2006-08-09 Therapeutic compounds
PCT/GB2007/050472 WO2008017883A2 (en) 2006-08-09 2007-08-06 4-oxo-4,5-dihydropyrrolo[1,2-a] quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp)

Publications (1)

Publication Number Publication Date
CA2659429A1 true CA2659429A1 (en) 2008-02-14

Family

ID=37056069

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002659429A Abandoned CA2659429A1 (en) 2006-08-09 2007-08-06 4-oxo-4,5-dihydropyrrolo[1,2-a]quinoxaline derivatives as inhibitors of poly(adp-ribose)polymerase(parp)

Country Status (7)

Country Link
US (1) US20100152180A1 (enExample)
EP (1) EP2057161A2 (enExample)
JP (1) JP2010500334A (enExample)
AU (1) AU2007283212A1 (enExample)
CA (1) CA2659429A1 (enExample)
GB (1) GB0615809D0 (enExample)
WO (1) WO2008017883A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5271897B2 (ja) 2006-05-31 2013-08-21 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ ポリ（ＡＤＰ−リボース）ポリメラーゼ（ＰＡＲＰ）の阻害剤としての、ピロロ［１，２−ａ］ピラジン−１（２Ｈ）−オン及びピロロ［１，２−ｄ］［１，２，４］トリアジン−１（２Ｈ）−オン誘導体
MX2009007053A (es) * 2006-12-28 2009-07-09 Abbott Lab Inhibidores de poli (adp-ribosa) polimerasa.
GB0804755D0 (en) 2008-03-14 2008-04-16 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2389379A1 (en) 2009-01-23 2011-11-30 Takeda Pharmaceutical Company Limited Poly (ADP-Ribose) Polymerase (PARP) Inhibitors
US8541417B2 (en) 2009-07-30 2013-09-24 Takeda Pharmaceutical Company Limited Poly (ADP-ribose) polymerase (PARP) inhibitors
ES2562903T3 (es) * 2011-07-13 2016-03-09 Santen Pharmaceutical Co., Ltd Nuevo compuesto que tiene actividad inhibidora de PARP
CN103130723B (zh) 2011-11-30 2015-01-14 成都地奥制药集团有限公司 一种多聚(adp-核糖)聚合酶抑制剂
CA2870062A1 (en) * 2012-06-20 2013-12-27 F.Hoffmann-La Roche Ag Pyrrolopyrazone inhibitors of tankyrase
CN103936735B (zh) * 2014-04-04 2015-11-11 沈阳工业大学 氮杂苯并薁衍生物及其制备方法和用途
IL298941A (en) 2020-06-11 2023-02-01 Chdi Foundation Inc Heterocyclic compounds and imaging agents for the imaging of huntingtin protein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
GB0017508D0 (en) * 2000-07-17 2000-08-30 Novartis Ag Antimicrobials
ITMI20002358A1 (it) * 2000-10-31 2002-05-01 Flavio Moroni Derivati di tieno ,2, 3-c|isochinolin-3-one come inibitori della poli(a dp-ribosio)polimerasi
NZ555491A (en) * 2005-01-03 2010-01-29 Univ Siena Aryl piperazine derivatives for the treatment of neuropsychiatric disorders
EP1798233A1 (en) * 2005-12-19 2007-06-20 Faust Pharmaceuticals Pyrrolo[1,2-a]quinoxaline derivatives as Adenosine A3 receptor modulators and uses thereof

Also Published As

Publication number Publication date
JP2010500334A (ja) 2010-01-07
US20100152180A1 (en) 2010-06-17
AU2007283212A1 (en) 2008-02-14
GB0615809D0 (en) 2006-09-20
WO2008017883A3 (en) 2008-04-03
WO2008017883A2 (en) 2008-02-14
EP2057161A2 (en) 2009-05-13

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