CA2659097A1 - Nouvelles methodes de detoxication d'esters - Google Patents

Nouvelles methodes de detoxication d'esters Download PDF

Info

Publication number
CA2659097A1
CA2659097A1 CA002659097A CA2659097A CA2659097A1 CA 2659097 A1 CA2659097 A1 CA 2659097A1 CA 002659097 A CA002659097 A CA 002659097A CA 2659097 A CA2659097 A CA 2659097A CA 2659097 A1 CA2659097 A1 CA 2659097A1
Authority
CA
Canada
Prior art keywords
bche
hubche
variants
rhbche
activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002659097A
Other languages
English (en)
Inventor
John R. Cashman
Jun Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Biomolecular Research Institute
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2659097A1 publication Critical patent/CA2659097A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01008—Cholinesterase (3.1.1.8), i.e. butyrylcholine-esterase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10351—Methods of production or purification of viral material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Addiction (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002659097A 2006-06-07 2007-06-05 Nouvelles methodes de detoxication d'esters Abandoned CA2659097A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81137006P 2006-06-07 2006-06-07
US60/811,370 2006-06-07
PCT/US2007/013333 WO2007146003A2 (fr) 2006-06-07 2007-06-05 Nouvelles méthodes de désintoxication d'un ester

Publications (1)

Publication Number Publication Date
CA2659097A1 true CA2659097A1 (fr) 2007-12-21

Family

ID=38832354

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002659097A Abandoned CA2659097A1 (fr) 2006-06-07 2007-06-05 Nouvelles methodes de detoxication d'esters

Country Status (6)

Country Link
EP (1) EP2035032A2 (fr)
JP (1) JP2009539376A (fr)
CN (1) CN101500600A (fr)
AU (1) AU2007258665A1 (fr)
CA (1) CA2659097A1 (fr)
WO (1) WO2007146003A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103966245B (zh) * 2013-02-04 2017-06-16 南京杰蒙生物技术有限公司 利用基因敲入和核移植技术在转基因动物生产重组人丁酰胆碱酯酶的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001625A (en) * 1995-05-19 1999-12-14 The United States Of America As Represented By The Secretary Of The Army Site-directed mutagenesis of esterases
CA2433057A1 (fr) * 2000-12-26 2002-08-22 Applied Molecular Evolution, Inc. Variants de polypeptides de butyrylcholinesterase a efficacite accrue et methodes d'utilisation associees
EP1458860A2 (fr) * 2001-12-21 2004-09-22 Nexia Biotechnologies, Inc. Production de butyrylcholinesterases par des mammiferes transgeniques

Also Published As

Publication number Publication date
JP2009539376A (ja) 2009-11-19
WO2007146003A2 (fr) 2007-12-21
EP2035032A2 (fr) 2009-03-18
AU2007258665A1 (en) 2007-12-21
CN101500600A (zh) 2009-08-05
WO2007146003A3 (fr) 2008-10-16

Similar Documents

Publication Publication Date Title
Fournier et al. Acetylcholinesterase. Two types of modifications confer resistance to insecticide.
Mukherjee et al. Organophosphorus nerve agents: types, toxicity, and treatments
Ekström et al. Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates
Masson et al. Butyrylcholinesterase for protection from organophosphorus poisons: catalytic complexities and hysteretic behavior
Schulze et al. Design of acetylcholinesterases for biosensor applications
Ghanem et al. Detoxification of organophosphate nerve agents by bacterial phosphotriesterase
de Koning et al. Peripheral site ligand conjugation to a non-quaternary oxime enhances reactivation of nerve agent-inhibited human acetylcholinesterase
Amitai et al. Enhanced stereoselective hydrolysis of toxic organophosphates by directly evolved variants of mammalian serum paraoxonase
CA2003273A1 (fr) Polypeptides catalytiques et reactifs; preparation et utilisation
Melzer et al. Reversed enantioselectivity of diisopropyl fluorophosphatase against organophosphorus nerve agents by rational design
JPH05508079A (ja) 哺乳類ホスホジエステラーゼをコードするｄｎａ
Zhou et al. An Antibody-Catalyzed Allylic Sulfoxide− Sulfenate Rearrangement
DK2385109T3 (en) Group of esterases for the enantioselective production of fine and specialty chemicals
Radi et al. Structure and function of cholinesterases
WO2006076742A2 (fr) Procedes et compositions pour accroitre la permeabilite membranaire
US20070286846A1 (en) Novel methods for ester detoxication
Saxena et al. Characterization of butyrylcholinesterase from porcine milk
CA2659097A1 (fr) Nouvelles methodes de detoxication d'esters
Kanamori-Kataoka et al. Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON1) polymorphism in the coding region (Q192R)
Hörnberg et al. Crystal structures of oxime-bound fenamiphos-acetylcholinesterases: Reactivation involving flipping of the His447 ring to form a reactive Glu334–His447–oxime triad
Darrouzet et al. Structure and function of the bacterial bc 1 complex: Domain movement, subunit interactions, and emerging rationale engineering attempts
Chandrasekaran et al. In vitro characterization of organophosphorus compound hydrolysis by native and recombinant human prolidase.
Mattern‐Dogru et al. Potential active‐site residues in polyneuridine aldehyde esterase, a central enzyme of indole alkaloid biosynthesis, by modelling and site‐directed mutagenesis
Tan et al. Molecular cloning and characterization of an atypical butyrylcholinesterase-like protein in zebrafish
Cha et al. Selective replacement of the catalytic zinc of the human stromelysin-1 catalytic domain

Legal Events

Date Code Title Description
FZDE Dead

Effective date: 20130605