CA2657973A1 - Therapeutic compounds - Google Patents
Therapeutic compounds Download PDFInfo
- Publication number
- CA2657973A1 CA2657973A1 CA002657973A CA2657973A CA2657973A1 CA 2657973 A1 CA2657973 A1 CA 2657973A1 CA 002657973 A CA002657973 A CA 002657973A CA 2657973 A CA2657973 A CA 2657973A CA 2657973 A1 CA2657973 A1 CA 2657973A1
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- Prior art keywords
- pain
- disease
- adenosine
- use according
- cancer
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
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- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
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| US60/837,308 | 2006-08-11 | ||
| PCT/EP2007/056375 WO2008000743A2 (en) | 2006-06-27 | 2007-06-26 | Novel 2',3'-methylidene acetyl adenosine prodrugs for use as prodrugs for adenosine receptor agonists |
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| CA2657973A1 true CA2657973A1 (en) | 2008-01-03 |
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| EP (1) | EP2066685B1 (https=) |
| JP (1) | JP2009541436A (https=) |
| CN (1) | CN101479290A (https=) |
| AT (1) | ATE500263T1 (https=) |
| AU (1) | AU2007263726A1 (https=) |
| BR (1) | BRPI0713901A2 (https=) |
| CA (1) | CA2657973A1 (https=) |
| DE (1) | DE602007012904D1 (https=) |
| ES (1) | ES2361886T3 (https=) |
| RU (1) | RU2009102512A (https=) |
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| US20100160250A1 (en) * | 2008-12-18 | 2010-06-24 | Douglass Iii James G | Method for treating inflammatory conditions |
| RU2478392C2 (ru) * | 2011-05-20 | 2013-04-10 | Евгений Петрович Измайлов | Способ консервативного и физиотерапевтического лечения серозно-геморрагического плеврита |
| RU2478391C2 (ru) * | 2011-05-20 | 2013-04-10 | Евгений Петрович Измайлов | Способ физиотерапевтического и консервативного лечения плеврита |
| US9822141B2 (en) | 2012-08-01 | 2017-11-21 | Lewis And Clark Pharmaceuticals, Inc. | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists |
| MX367879B (es) * | 2012-08-01 | 2019-09-10 | Lewis And Clark Pharmaceuticals Inc | N-alquil 2-(disustituido)alquiladenosin-5-uronamidas como agonistas a2a. |
| US11541071B1 (en) * | 2021-12-16 | 2023-01-03 | Ascletis BioScience Co., Ltd | Nucleoside derivatives and methods of use thereof |
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| US5968914A (en) | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
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| CN1292073C (zh) | 1997-06-03 | 2006-12-27 | 森庸厚 | 天然抗肿瘤性或抗病毒性物质及其用途 |
| US6117878A (en) * | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
| US6958324B2 (en) * | 1998-12-02 | 2005-10-25 | Inotek Pharmaceuticals Corporation | Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease |
| US6214807B1 (en) * | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
| EP1255550A2 (en) * | 2000-02-17 | 2002-11-13 | Cv Therapeutics, Inc. | Method for identifying and using a 2b adenosine receptor antagonists to mediate mammalian cell proliferation |
| US6995148B2 (en) * | 2001-04-05 | 2006-02-07 | University Of Pittsburgh | Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy |
| US6713638B2 (en) * | 2001-05-18 | 2004-03-30 | Joel M. Linden | 2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors |
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| GB0228723D0 (en) | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
| GB0305150D0 (en) | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Use of therapeutic compounds |
| GB0305149D0 (en) | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Compounds for the treatment of pain |
| US20090068101A9 (en) * | 2003-06-09 | 2009-03-12 | Endacea, Inc. | A1 Adenosine Receptor Antagonists |
| EP1646390B1 (en) * | 2003-07-22 | 2008-10-08 | Cv Therapeutics, Inc. | A1 adenosine receptor antagonists |
| BRPI0412577A (pt) * | 2003-07-31 | 2006-09-19 | Sanofi Aventis | derivados de aminoquinolina e seu uso como ligantes de adenosina a3 |
| US7504497B2 (en) * | 2003-10-21 | 2009-03-17 | Inspire Pharmaceuticals, Inc. | Orally bioavailable compounds and methods for inhibiting platelet aggregation |
| JP2007514647A (ja) * | 2003-10-21 | 2007-06-07 | インスパイアー ファーマシューティカルズ，インコーポレイティド | テトラヒドロ−フロ［３，４−ｄ］ジオキソール化合物並びに血小板凝集を阻害する組成物及び方法 |
| JP2007509180A (ja) * | 2003-10-21 | 2007-04-12 | インスパイアー ファーマシューティカルズ，インコーポレイティド | 疼痛を治療するための、非ヌクレオチド組成物および方法 |
| WO2006033709A2 (en) * | 2004-07-29 | 2006-03-30 | Metabasis Therapeutics, Inc. | Novel nucleoside derivatives |
| US20080221060A1 (en) | 2004-03-05 | 2008-09-11 | Martyn Pritchard | Therapeutic Compounds |
| AU2005231440B9 (en) * | 2004-04-02 | 2012-02-23 | Dogwood Pharmaceuticals, Inc. | Selective antagonists of A2A adenosine receptors |
| US7396825B2 (en) * | 2004-05-03 | 2008-07-08 | University Of Virginia Patent Foundation | Agonists of A2A adenosine receptors for treatment of diabetic nephropathy |
| JP2008512457A (ja) * | 2004-09-09 | 2008-04-24 | アメリカ合衆国 | Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体 |
| WO2006113615A2 (en) * | 2005-04-15 | 2006-10-26 | Sloan-Kettering Institute For Cancer Research | Anti-microbial agents and uses thereof |
| US7514417B2 (en) * | 2005-05-19 | 2009-04-07 | Cv Therapeutics, Inc. | A1 adenosine receptor agonists |
| GB0514809D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| EP1983990B1 (en) * | 2006-01-26 | 2011-03-23 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | A3 adenosine receptor allosteric modulators |
| WO2007092936A2 (en) * | 2006-02-08 | 2007-08-16 | University Of Virginia Patent Foundation | Method to treat gastric lesions |
| CA2644996A1 (en) * | 2006-03-02 | 2007-09-13 | Cv Therapeutics, Inc. | A2a adenosine receptor antagonists |
| WO2007109547A2 (en) * | 2006-03-17 | 2007-09-27 | Cv Therapeutics, Inc. | Method of preventing and treating hepatic disease using a2b adenosine receptor antagonists |
| CA2655310A1 (en) * | 2006-06-22 | 2008-05-29 | Cv Therapeutics, Inc. | Use of a2a adenosine receptor agonists in the treatment of ischemia |
| EP1903044A1 (en) * | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
| US7723343B2 (en) * | 2007-03-30 | 2010-05-25 | King Pharmaceuticals Research And Development, Inc. | Adenosine A2A receptor antagonists |
| US20080312160A1 (en) * | 2007-04-09 | 2008-12-18 | Guerrant Richard L | Method of treating enteritis, intestinal damage, and diarrhea from c. difficile with an a2a adenosine receptor agonist |
| US20080262001A1 (en) * | 2007-04-23 | 2008-10-23 | Adenosine Therapeutics, Llc | Agonists of a2a adenosine receptors for treating recurrent tumor growth in the liver following resection |
| US8153781B2 (en) * | 2007-06-29 | 2012-04-10 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Dendrimer conjugates of agonists and antagonists of the GPCR superfamily |
| WO2009052310A1 (en) * | 2007-10-16 | 2009-04-23 | Cv Therapeutics, Inc | A3 adenosine receptor antagonists |
| WO2009061516A1 (en) * | 2007-11-08 | 2009-05-14 | New York University School Of Medicine | Medical implants containing adenosine receptor agonists and methods for inhibiting medical implant loosening |
| CN101938904A (zh) * | 2008-01-09 | 2011-01-05 | PGx健康有限责任公司 | 用a2ar激动剂鞘内治疗神经性疼痛 |
| US20090203689A1 (en) * | 2008-02-07 | 2009-08-13 | Arvinder Dhalla | Abca-1 elevating compounds and methods |
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Also Published As
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| RU2009102512A (ru) | 2010-08-10 |
| JP2009541436A (ja) | 2009-11-26 |
| US20080027081A1 (en) | 2008-01-31 |
| US7906518B2 (en) | 2011-03-15 |
| BRPI0713901A2 (pt) | 2013-01-08 |
| EP2066685A2 (en) | 2009-06-10 |
| AU2007263726A1 (en) | 2008-01-03 |
| DE602007012904D1 (de) | 2011-04-14 |
| WO2008000743A2 (en) | 2008-01-03 |
| ATE500263T1 (de) | 2011-03-15 |
| ES2361886T3 (es) | 2011-06-24 |
| WO2008000743A3 (en) | 2008-02-21 |
| CN101479290A (zh) | 2009-07-08 |
| EP2066685B1 (en) | 2011-03-02 |
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| FZDE | Discontinued |