CA2657973A1 - Therapeutic compounds - Google Patents
Therapeutic compounds Download PDFInfo
- Publication number
- CA2657973A1 CA2657973A1 CA002657973A CA2657973A CA2657973A1 CA 2657973 A1 CA2657973 A1 CA 2657973A1 CA 002657973 A CA002657973 A CA 002657973A CA 2657973 A CA2657973 A CA 2657973A CA 2657973 A1 CA2657973 A1 CA 2657973A1
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- Prior art keywords
- pain
- disease
- adenosine
- use according
- cancer
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Biochemistry (AREA)
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- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
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| SE0601396-5 | 2006-06-27 | ||
| SE0601396 | 2006-06-27 | ||
| US83730806P | 2006-08-11 | 2006-08-11 | |
| US60/837,308 | 2006-08-11 | ||
| PCT/EP2007/056375 WO2008000743A2 (en) | 2006-06-27 | 2007-06-26 | Novel 2',3'-methylidene acetyl adenosine prodrugs for use as prodrugs for adenosine receptor agonists |
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| CA2657973A1 true CA2657973A1 (en) | 2008-01-03 |
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| EP (1) | EP2066685B1 (https=) |
| JP (1) | JP2009541436A (https=) |
| CN (1) | CN101479290A (https=) |
| AT (1) | ATE500263T1 (https=) |
| AU (1) | AU2007263726A1 (https=) |
| BR (1) | BRPI0713901A2 (https=) |
| CA (1) | CA2657973A1 (https=) |
| DE (1) | DE602007012904D1 (https=) |
| ES (1) | ES2361886T3 (https=) |
| RU (1) | RU2009102512A (https=) |
| WO (1) | WO2008000743A2 (https=) |
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| CN102014959B (zh) * | 2008-03-10 | 2016-01-20 | 康奈尔大学 | 血脑屏障通透性的调节 |
| AU2009335800A1 (en) * | 2008-12-18 | 2011-08-04 | Inspire Pharmaceuticals, Inc. | Method for treating inflammatory conditions |
| RU2478391C2 (ru) * | 2011-05-20 | 2013-04-10 | Евгений Петрович Измайлов | Способ физиотерапевтического и консервативного лечения плеврита |
| RU2478392C2 (ru) * | 2011-05-20 | 2013-04-10 | Евгений Петрович Измайлов | Способ консервативного и физиотерапевтического лечения серозно-геморрагического плеврита |
| US9822141B2 (en) | 2012-08-01 | 2017-11-21 | Lewis And Clark Pharmaceuticals, Inc. | N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists |
| IN2015DN00538A (https=) * | 2012-08-01 | 2015-06-26 | Lewis And Clark Pharmaceuticals Inc | |
| US11541071B1 (en) * | 2021-12-16 | 2023-01-03 | Ascletis BioScience Co., Ltd | Nucleoside derivatives and methods of use thereof |
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| US5968914A (en) | 1987-10-28 | 1999-10-19 | Pro-Neuron, Inc. | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
| US5691188A (en) * | 1994-02-14 | 1997-11-25 | American Cyanamid Company | Transformed yeast cells expressing heterologous G-protein coupled receptor |
| ATE236922T1 (de) | 1997-06-03 | 2003-04-15 | Itochu Techno Chem Inc | Natürliche antitumor- oder antivirale substanzen und ihre anwendung |
| US6117878A (en) * | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
| US6958324B2 (en) * | 1998-12-02 | 2005-10-25 | Inotek Pharmaceuticals Corporation | Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease |
| US6214807B1 (en) * | 1999-06-22 | 2001-04-10 | Cv Therapeutics, Inc. | C-pyrazole 2A A receptor agonists |
| CA2400206A1 (en) * | 2000-02-17 | 2001-08-23 | Cv Therapeutics, Inc. | Method for identifying and using a2b adenosine receptor antagonists to mediate mammalian cell proliferation |
| US6995148B2 (en) * | 2001-04-05 | 2006-02-07 | University Of Pittsburgh | Adenosine cyclic ketals: novel adenosine analogues for pharmacotherapy |
| US6713638B2 (en) * | 2001-05-18 | 2004-03-30 | Joel M. Linden | 2-amino-3-aroyl-4,5 alkylthiophenes: agonist allosteric enhancers at human A1 adenosine receptors |
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| GB0228723D0 (en) | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
| GB0305150D0 (en) | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Use of therapeutic compounds |
| GB0305149D0 (en) | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Compounds for the treatment of pain |
| WO2004110379A2 (en) * | 2003-06-09 | 2004-12-23 | Endacea, Inc. | A1 adenosine receptor antagonists |
| EP1646390B1 (en) * | 2003-07-22 | 2008-10-08 | Cv Therapeutics, Inc. | A1 adenosine receptor antagonists |
| EP1663982B1 (en) * | 2003-07-31 | 2007-11-21 | Sanofi-Aventis | Aminoquinoline derivatives and their use as adenosine a3 ligands |
| AU2004284098B2 (en) * | 2003-10-21 | 2009-07-16 | Inspire Pharmaceuticals, Inc. | Tetrahydro-furo [3,4-d] dioxole compounds and compositions and method for inhibiting platelet aggregation |
| GB2422782A (en) * | 2003-10-21 | 2006-08-09 | Inspire Pharmaceuticals Inc | Non-nucleotide compositions and method for treating pain |
| US7504497B2 (en) * | 2003-10-21 | 2009-03-17 | Inspire Pharmaceuticals, Inc. | Orally bioavailable compounds and methods for inhibiting platelet aggregation |
| CA2557285A1 (en) | 2004-03-05 | 2005-09-15 | Cambridge Biotechnology Limited | Adenosine receptor agonists |
| CA2563123A1 (en) * | 2004-04-02 | 2005-10-20 | Adenosine Therapeutics, Llc | Selective antagonists of a2a adenosine receptors |
| WO2005107463A1 (en) * | 2004-05-03 | 2005-11-17 | University Of Virginia Patent Foundation | Agonists of a2a adenosine receptors for treatment of diabetic nephropathy |
| EP1781101A2 (en) * | 2004-07-29 | 2007-05-09 | Metabasis Therapeutics, Inc. | Novel nucleoside derivatives |
| JP2008512457A (ja) * | 2004-09-09 | 2008-04-24 | アメリカ合衆国 | Ａ３及びａ１アデノシン受容体作用薬としてのプリン誘導体 |
| US8461128B2 (en) * | 2005-04-15 | 2013-06-11 | Sloan-Kettering Institute For Cancer Research | Anti-microbial agents and uses thereof |
| EP1881991A1 (en) * | 2005-05-19 | 2008-01-30 | Cv Therapeutics, Inc. | A1 adenosine receptor agonists |
| GB0514809D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| CN101410114B (zh) * | 2006-01-26 | 2012-07-04 | 美国政府卫生与公共服务部 | A3腺苷受体别构调节剂 |
| WO2007092936A2 (en) * | 2006-02-08 | 2007-08-16 | University Of Virginia Patent Foundation | Method to treat gastric lesions |
| CA2644996A1 (en) * | 2006-03-02 | 2007-09-13 | Cv Therapeutics, Inc. | A2a adenosine receptor antagonists |
| AU2007227021B2 (en) * | 2006-03-17 | 2012-12-20 | Gilead Sciences, Inc. | Method of preventing and treating hepatic disease using A2B adenosine receptor antagonists |
| JP2009541354A (ja) * | 2006-06-22 | 2009-11-26 | シーブイ・セラピューティクス・インコーポレイテッド | 虚血の治療におけるａ２ａアデノシン受容体アゴニストの使用 |
| EP1903044A1 (en) * | 2006-09-14 | 2008-03-26 | Novartis AG | Adenosine Derivatives as A2A Receptor Agonists |
| US7691869B2 (en) * | 2007-03-30 | 2010-04-06 | King Pharmaceuticals Research And Development, Inc. | Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity |
| WO2008124150A1 (en) * | 2007-04-09 | 2008-10-16 | University Of Virginia Patent Foundation | Method of treating enteritis, intestinal damage, and diarrhea from c. difficile with an a2a adenosine receptor agonist |
| US20080262001A1 (en) * | 2007-04-23 | 2008-10-23 | Adenosine Therapeutics, Llc | Agonists of a2a adenosine receptors for treating recurrent tumor growth in the liver following resection |
| EP2170401A1 (en) * | 2007-06-29 | 2010-04-07 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Dendrimer conjugates of agonists and antagonists of the gpcr superfamily |
| JP2011500716A (ja) * | 2007-10-16 | 2011-01-06 | ギリアード・パロ・アルト・インコーポレイテッド | Ａ３アデノシン受容体アンタゴニスト |
| WO2009061516A1 (en) * | 2007-11-08 | 2009-05-14 | New York University School Of Medicine | Medical implants containing adenosine receptor agonists and methods for inhibiting medical implant loosening |
| JP2011509305A (ja) * | 2008-01-09 | 2011-03-24 | ピージーエックスヘルス、リミテッド、ライアビリティー、カンパニー | Ａ２ａｒアゴニストによる神経障害性疼痛の髄腔内治療 |
| CN101983062A (zh) * | 2008-02-07 | 2011-03-02 | 吉利德帕洛阿尔托股份有限公司 | 提高abca-1的化合物及其用途 |
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- 2007-06-26 BR BRPI0713901-2A patent/BRPI0713901A2/pt not_active IP Right Cessation
- 2007-06-26 JP JP2009517173A patent/JP2009541436A/ja active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2009541436A (ja) | 2009-11-26 |
| WO2008000743A2 (en) | 2008-01-03 |
| US20080027081A1 (en) | 2008-01-31 |
| ES2361886T3 (es) | 2011-06-24 |
| US7906518B2 (en) | 2011-03-15 |
| EP2066685A2 (en) | 2009-06-10 |
| RU2009102512A (ru) | 2010-08-10 |
| AU2007263726A1 (en) | 2008-01-03 |
| EP2066685B1 (en) | 2011-03-02 |
| BRPI0713901A2 (pt) | 2013-01-08 |
| CN101479290A (zh) | 2009-07-08 |
| WO2008000743A3 (en) | 2008-02-21 |
| ATE500263T1 (de) | 2011-03-15 |
| DE602007012904D1 (de) | 2011-04-14 |
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| FZDE | Discontinued |